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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 23681. Отображено 100.
12-01-2012 дата публикации

Imaging optical system, microscope apparatus including the imaging optical system, and stereoscopic microscope apparatus

Номер: US20120008194A1
Автор: Hiroaki Nakayama, Masahiro Mizuta, Yumiko Ouchi
Принадлежит: Nikon Corp

Provided is an imaging optical system that can prevent enlargement of the entire optical system of a microscope apparatus while holding a wide distance between optical axes to allow enlargement to a low-power range. A variable power optical system 3 used in a parallel stereoscopic microscope apparatus 100 and the like includes a plurality of optical paths in which optical axes are arranged substantially parallel, includes a plurality of lens groups that change the magnification of a diameter of a luminous flux entering substantially parallel to each of the optical paths to eject the luminous flux as substantially parallel luminous fluxes, and at least two lens groups move along the optical axis in each optical path according to the change in the magnification. At least two lens groups of at least one optical path among the plurality of optical paths move in a direction including a component perpendicular to the optical axis according to the change in the magnification at least part of a section where the magnification is changed from a high-power end state to a low-power end

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Номер записи: 1
12-01-2012 дата публикации

ATR objective for an IR microscope and method for operation thereof

Номер: US20120008196A1
Автор: Matthias Boese, Michael Juette, Rolf Steinbrunn
Принадлежит: BRUKER OPTIK GMBH

ATR (attenuated total reflection) objective ( 1 ) for an IR (infrared) microscope, comprising a Cassegrain objective ( 2 ) which focuses on a sample position ( 3 ) and the two mirrors ( 2 a, 2 b ) of which each have a central bore ( 5 a, 5 b ), an ATR crystal ( 7 ), a holding bar ( 8 ) which is guided through the two central bores ( 5 a, 5 b ) and to one end of which on the side of the sample, the ATR crystal ( 7 ) is mounted, a holding element ( 10 ) which is disposed in the area or beyond the side of the Cassegrain objective ( 2 ) facing away from the sample, thin struts ( 9 ) which rigidly connect the holding bar ( 8 ) to the holding element ( 10 ) and intersect an optical path of the ATR objective ( 1 ) entering or exiting the Cassegrain objective ( 2 ) in such a fashion that they shade less than 10% of the beam cross-section of the optical path, and a motor drive ( 12 ) for axial movement of the holding element ( 10 ) relative to the sample position ( 3 ). A practicable, automated ATR objective for an IR microscope thereby enables, in particular, simple adjustment of operating modes and different contact pressures of the ATR crystal with respect to a sample ( 19 ).

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Номер записи: 2
19-01-2012 дата публикации

Methods and systems for enhanced medical procedure visualization

Номер: US20120016244A1
Автор: Mark Humayun, Sean Caffey
Принадлежит: Doheny Eye Institute of USC

The present invention employs image intensification for medical procedures within the human body. Methods and systems of the invention utilize infrared radiation (e.g. greater than about 750 nm) illumination and visualization of a surgical treatment area Preferred methods and systems of the invention incorporate use of an infrared radiation visualization system which may be known as “night vision” systems.

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Номер записи: 3
02-02-2012 дата публикации

Holographic microscope

Номер: US20120026313A1
Автор: Doeke Hekstra, Seppe Kuehn, Stanislas Leibler, Zak Frentz
Принадлежит: ROCKEFELLER UNIVERSITY

A holography attachment device for a digital imaging device. The holography attachment device including a chamber having a proximate end configured to attach to the digital imaging device. A distal end of the chamber includes a wall. Also, the chamber includes a sample holder section located between the proximate end and the distal end. The sample holder section is configured to receive a sample. The chamber is configured to attach to the digital imaging device.

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Номер записи: 4
02-02-2012 дата публикации

On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference

Номер: US20120026509A1
Автор: Axel Scherer, Changhuei Yang, Demetri Psaltis, Xin Heng, Xiquan Cui
Принадлежит: California Institute of Technology CalTech

A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface wave assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.

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Номер записи: 5
02-02-2012 дата публикации

Microscope system

Номер: US20120026582A1
Автор: Masashi Okabe, Naohiro Ariga
Принадлежит: Olympus Corp

Changes in moving speed of an observation image relative to the viewing range of an image displayed on a display unit are reduced, even if a stage is driven when the viewing range of the image on the display unit is changed. A microscope system is provided, including a stage on which a specimen is mounted and that can be moved in a direction that intersects with an optical axis of illumination light irradiated on the specimen; an observation optical system that acquires an image of the specimen on which the illumination light is irradiated; a viewing-range setting unit that sets a viewing range of the image acquired by the observation optical system and displayed on a display unit; a ratio calculating unit that calculates a ratio of the viewing range of the image, which is set by the viewing-range setting unit, relative to a maximum image-acquisition area that can be captured by the observation optical system; and a stage controller that controls the moving speed of the stage in accordance with the ratio calculated by the ratio calculating unit.

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Номер записи: 6
16-02-2012 дата публикации

Method for separating detection signals in the beam path of an optical device

Номер: US20120038907A1
Автор: Frank Schreiber
Принадлежит: Leica Microsystems CMS GmbH

A method for separating detection signals in the beam path of an optical device, different signals being formed in a defined temporal sequence, is wherein a suppression or separation of signals is performed on the basis of the temporal sequence which is known or can be determined/established.

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Номер записи: 7
01-03-2012 дата публикации

Laser microscope

Номер: US20120050733A1
Автор: Shinichi Takimoto
Принадлежит: Olympus Corp

Provided is a laser microscope, in which laser irradiation optical systems ( 3, 4, 5, 6 ) are employed for coaxially irradiating a sample with a CARS laser beam and a Raman scattering laser beam, and CARS light is detected by CARS light detecting means ( 12 ) and Raman scattering light is detected by Raman scattering light detecting means ( 13 ). In this manner, Raman scattering light observation and CARS light observation can be selectively performed without moving the sample, so that the vibration frequency for the CARS light observation can be efficiently selected without needing complicated work.

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Номер записи: 8
15-03-2012 дата публикации

Digital microscope with coaxial light output

Номер: US20120062721A1
Автор: Paul Neng-Wei Wu
Принадлежит: Anmo Electronics Corp

A digital microscope is disclosed including: an image sensing circuit having an image sensing area thereon; a first object lens aligned with the image sensing area along an axis; a luminance device positioned outside the axis for emitting light toward a direction that is not coaxial with the axis; a light redirector positioned outside the axis for redirecting the light emitted from the luminance device; and a beam splitter positioned on the axis for changing the direction of light from the light redirector to provide an output light that is outputted substantially along the axis and coaxial with the axis; wherein the first object lens is positioned between the image sensing area and the beam splitter.

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Номер записи: 9
22-03-2012 дата публикации

Method and apparatus for retrieval of amplitude and phase of nonlinear electromagnetic waves

Номер: US20120069345A1
Автор: Christian Depeursinge, Etienne Shaffer
Принадлежит: Ecole Polytechnique Federale de Lausanne EPFL

The present invention discloses a method and its associated apparatus to retrieve the amplitude and, especially, the phase of nonlinear electromagnetic waves. The application field of the present invention is optical imaging. A sample is probed by coherent electromagnetic radiation, and by a nonlinear interaction such as harmonic generation a nonlinear object wave is emitted. A nonlinear reference wave is generated by interaction of the same nature with the coherent electromagnetic radiation, and an interference between the nonlinear object wave and the nonlinear reference wave is sensed by a detector array. As an example, the technique makes possible real-time nanometric localization and tracking of nonlinear field emitters, such as, but not limited to, nanoparticles.

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Номер записи: 10
10-05-2012 дата публикации

Optical probe with feedback correction

Номер: US20120113491A1
Автор: Augustinus Laurentius Braun, Bernardus Hendrikus Wilhelmus Hendriks, Cornelius Antonius Hezemans, Nenad Mihajlovic, Waltherus Cornelis Jozef Bierhoff
Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS NV

The present invention relates to an optical probe ( 1 ) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system ( 9, 10 ) comprising drive coils ( 9 ) capable of displacing the distal end ( 3 ) of an optical guide ( 2 ) housed ( 4 ) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

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Номер записи: 11
10-05-2012 дата публикации

Novel Multi-Point Scan Architecture

Номер: US20120113506A1
Автор: Andrew R. Rouse, Anthony A. Tanbakuchi, Arthur F. Gmitro
Принадлежит: Gmitro Arthur F, Rouse Andrew R, Tanbakuchi Anthony A

The embodiments of this invention use a multi-point scanning geometry. This design maintains the high frame rate of the slit-scan system and still allows both grayscale and multi-spectral imaging. In a confocal configuration, the multi-point scanning system's confocal performance is close to that of a single point scan system and is expected to yield improved depth imaging when compared to a slit-scan system, faster imaging than a point scan system, and the capability for multi-spectral imaging not readily achievable in a Nipkow disk based confocal system.

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Номер записи: 12
17-05-2012 дата публикации

Interference microscope and measuring apparatus

Номер: US20120120485A1
Автор: Fumio Ootomo, Hisashi Isozaki, Kazuhiro Miyakawa, Kazuo Nunokawa, Masayuki Momiuchi, Miyano Nunokawa
Принадлежит: Topcon Corp

In an interference microscope and a measuring device for observing and inspecting the surface and inside of a specimen such as a wafer by applying laser light to the specimen and using an interferometer, a reference optical path for conducting light is provided between a beam splitter and a reference mirror, and a measurement optical path for conducting light is provided between the beam splitter and the specimen, thereby providing an optical path difference between the reference optical path and the measurement optical path. Further, the reference mirror is tilted slightly, thereby forming interference fringes on detection means. It is possible to measure the surface shape of the specimen (measurement object) such as a wafer only by slightly tilting the reference mirror with a simple configuration and locate the accurate coordinate positions of foreign particles and pole pieces.

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Номер записи: 13
31-05-2012 дата публикации

Method for imaging on thin solid-state interface between two fluids

Номер: US20120135410A1
Автор: Amit Meller, Gautam V. Soni
Принадлежит: Boston University

Described herein is a fluid cell for an optical microscopy tool having a solid state membrane having a first side and a second, opposing side; a first fluid chamber comprising a first fluid having a first refractive index located on the first side of the membrane; and, a second fluid chamber comprising a second fluid having a second refractive index located on the second side of the membrane, the second refractive index being different than the first refractive index. Also described herein is a method for imaging a single biomolecule, the method including generating a field of evanescent illumination at a solid state membrane between a first fluid and a second fluid having different refractive indexes; and detecting light emitted by optical detectors linked to the single biomolecules at the solid state membrane.

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Номер записи: 14
26-07-2012 дата публикации

Microscope objective with at least one lens group that can be moved along the optical axis

Номер: US20120188660A1
Автор: Georg Herbst, Ingo Fahlbusch
Принадлежит: CARL ZEISS MICROIMAGING GMBH

The present disclosure relates to a family of microscopes, each with at least one lens group that includes at least one lens and a lens mount and moves along the optical axis via a drive system for The drive system includes a rotary motor and transmission elements to convert the rotary motion to linear motion to transmit the translational movement to the lens group, and, simultaneously, to prevent rotations of the lens group about the optical axis. In an embodiment, the rotating output shaft of the motor is connected with a screw spindle that engages with a threaded hole machined into the lens mount, so that the lens group is directly moved in a translational manner. The engagement of the screw spindle with the lens mount both effects the translational movement of the lens group and secures the lens group against rotation about the optical axis.

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Номер записи: 15
02-08-2012 дата публикации

Laser system for a microscope and method for operating a laser system for a microscope

Номер: US20120193513A1
Автор: Bernd Widzgowski, Holger Birk, Volker Seyfried
Принадлежит: Leica Microsystems CMS GmbH

The invention relates to a laser system ( 20 ) for a microscope, comprising a laser module ( 22 ), a beam correction device ( 26 ), an optical fiber ( 31 ), a measuring element ( 34 ), and an external controller ( 37 ). The laser module ( 22 ) generates a light beam ( 24 ). The light beam ( 24 ) penetrates the beam correction device ( 26 ), which corrects a deviation of an actual value of at least one parameter of the light beam ( 24 ) from a target value of the parameter. The corrected light beam ( 24 ) is coupled into the optical fiber ( 31 ). The measuring element ( 34 ) is connected downstream of the optical fiber ( 31 ) and captures an actual value ( 36 ) of the intensity of at least one partial beam ( 32 ) of the corrected light beam ( 24 ). The external controller ( 37 ), regulates the actual value ( 36 ) of the intensity to a prescribed target value for the intensity.

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Номер записи: 16
09-08-2012 дата публикации

Transillumination device for a microscope

Номер: US20120200905A1
Автор: Didier Henry, Harald Schnitzler, Robert Paulus
Принадлежит: Leica Microsystems Schweiz AG

A transillumination device ( 150 ) for a microscope ( 100 ) comprises a flat panel light source ( 151 ), a diaphragm arrangement ( 152 ) arranged behind the flat panel light source ( 151 ) in the radiating direction (AR) that comprises two diaphragm elements movable relative to one another, at least one of the two diaphragm elements having a cutout, the two diaphragm elements defining, together with the at least one cutout, a diaphragm opening, wherein the dimensions of the diaphragm opening in two mutually perpendicular directions are determined by the position of the diaphragm elements relative to one another.

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Номер записи: 17
09-08-2012 дата публикации

Flat panel light source for a transillumination device of a microscope

Номер: US20120201047A1
Автор: Harald Schnitzler, Reto Züst, Robert Paulus
Принадлежит: Leica Microsystems Schweiz AG

A flat panel light source ( 100 ) for a transillumination device of a microscope comprises a plate-shaped light guide ( 110 ) having a lower and an upper boundary surface and at least one lateral surface ( 113 to 116 ), and at least one light-emitting means ( 120, 122 ) arranged to radiate light ( 130 ) into the light guide ( 110 ) from at least two different directions, via at least one lateral surface serving as a light entrance surface, such that light propagates in the light guide ( 110 ) by total reflection, the total reflection being disrupted in defined fashion by an element ( 140 ) abutting against a contact surface at the lower boundary surface of the light guide ( 110 ) so an outcoupling of light occurs on the upper boundary surface, the planar area of the contact surface being smaller than that of the lower boundary surface, the element ( 140 ) producing a directed reflection of the light ( 130 ).

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Номер записи: 18
23-08-2012 дата публикации

Optical Apparatus, Method of Scanning, Lithographic Apparatus and Device Manufacturing Method

Номер: US20120212718A1
Автор: Arie Jeffrey Den Boef
Принадлежит: ASML Netherlands BV

An apparatus measures positions of marks on a lithographic substrate. A measurement optical system comprises illumination subsystem for illuminating the mark with a spot of radiation and a detecting subsystem for detecting radiation diffracted by the mark. A tilting mirror moves the spot of radiation relative to the reference frame of the measurement optical system synchronously with a scanning motion of the mark itself, to allow more time for accurate position measurements to be acquired. The mirror tilt axis is arranged along the intersection of the mirror plane with a pupil plane of the objective lens to minimize artifacts of the scanning. The same geometrical arrangement can be used for scanning in other types of apparatus, for example a confocal microscope.

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Номер записи: 19
23-08-2012 дата публикации

Two-dimensional optical scanner and light stimulus apparatus

Номер: US20120212791A1
Автор: Naobumi Okada
Принадлежит: Olympus Corp

Two-dimensional optical scanner includes: a first acousto-optical deflector (AOD) and a second AOD that deflects light according to a signal; a first driving unit that rotates the first AOD around axis perpendicular to a first plane including the light on and light from the first AOD; a first prism that is arranged adjacent to an emission end of the first AOD and compensates angular dispersion of the light; a second driving unit that rotates the second AOD around axis perpendicular to a second plane including the light on and light from the second AOD and perpendicular to the first plane; a second prism that is arranged adjacent to an emission end of the second AOD and compensates angular dispersion of the light; and a relay lens that allows the emission end of the first AOD and an incident end of the second AOD to be optically conjugate.

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Номер записи: 20
13-09-2012 дата публикации

Talbot Imaging Devices and Systems

Номер: US20120228475A1
Автор: Changhuei Yang, Shuo Pang
Принадлежит: California Institute of Technology CalTech

Talbot imaging systems comprising a Talbot element, a phase gradient generating device, a light detector, and a processor. The Talbot element repeats a Talbot image at a distance from the Talbot element. The phase gradient generating device scans the Talbot image at a plane at the distance from the Talbot element by incrementally changing a phase gradient of a light field incident the Talbot element. As the Talbot image is scanned, the light detector captures time varying data associated with light altered by an object located at the distance from the Talbot element. The processor reconstructs an image of the object based on the time-varying light data.

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Номер записи: 21
13-09-2012 дата публикации

Microscope

Номер: US20120229791A1
Автор: Helmut Lippert, Matthias Wald, Michael Goelles, Robert Hauschile, Wolfgang Bathe
Принадлежит: CARL ZEISS MICROIMAGING GMBH

A microscope including an illumination device providing a light sheet illuminating a sample region, said sheet having a planar extension along an illumination axis of an illumination beam path and a transverse axis lying normal to the illumination axis. A detection device detects light emitted from the sample region on a detection axis the illumination axis and detection axis as well as the transverse axis and the detection axis being oriented relative each other at an angle unequal zero. The detection device has a detection lens system arranged in the detection beam path and splitting means for splitting the detection beam path into two beam sub-paths. A dichroic beam splitter in the infinity region of the surface detectors is about 3 mm thick. Wobble plate(s) disposed orthogonal to each other relative to the detection axis arranged in one of the two beam sub-paths so measured values can be automatically superimposed.

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Номер записи: 22
13-09-2012 дата публикации

Microscope apparatus

Номер: US20120229883A1
Автор: Eiji Yokoi
Принадлежит: Olympus Corp

A microscope apparatus includes a laser beam source for emitting a laser beam, an objective lens for irradiating a sample with the laser beam, a phase-modulating spatial light modulator placed between the laser beam source and the objective lens at a position optically conjugate with a pupil position of the objective lens, and a beam diameter variable unit placed between the laser beam source and the phase-modulating spatial light modulator for varying a beam diameter of the laser beam incident to the phase-modulating spatial light modulator.

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Номер записи: 23
20-09-2012 дата публикации

Automatic stereological analysis of biological tissue including section thickness determination

Номер: US20120236120A1
Автор: Baishali Chaudhury, Daniel T. Elozory, Dmitry Goldgof, Kurt A. Kramer, Lawrence O. Hall, Om Pavithra Bonam, Peter R. Mouton
Принадлежит: Stereology Resource Center Inc, UNIVERSITY OF SOUTH FLORIDA

Systems and methods are provided for automatic determination of slice thickness of an image stack in a computerized stereology system, as well as automatic quantification of biological objects of interest within an identified slice of the image stack. Top and bottom boundaries of a slice can be identified by applying a thresholded focus function to determine just-out-of-focus focal planes. Objects within an identified slice can be quantified by performing a color processing segmentation followed by a gray-level processing segmentation. The two segmentation processes generate unique identifiers for features in an image that can then be used to produce a count of the features.

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Номер записи: 24
20-09-2012 дата публикации

Optical connector and endoscope system

Номер: US20120238821A1
Автор: Koji Yoshida, Tadashi Kasamatsu, Tatsuya YOSHIHIRO
Принадлежит: Individual

Provided is an optical connector including: an SI-type light source side optical fiber which is disposed on the light source side and an SI-type light receiving side optical fiber which is disposed on the light receiving side. Both optical fibers are optically coupled to each other by disposing an end surface of the light source side optical fiber and an end surface of the light receiving side optical fiber so as to face each other. The light source side optical fiber and the receiving side optical fiber are attachable to and detachable from each other. The light source side optical fiber includes a taper portion in which the diameter of the core portion increases toward the end surface of the light source side optical fiber.

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Номер записи: 25
27-09-2012 дата публикации

System for and Method of Performing Multi-Technique Imaging

Номер: US20120241596A1
Автор: Cagri A. Savran, Khalid M. Arif
Принадлежит: PURDUE RESEARCH FOUNDATION

A system for and method of performing multi-technique imaging are disclosed. Such multi-technique imaging system includes a surface for supporting a specimen and at least two illumination sources for producing light radiation. The system also includes a plurality of reflective and refractive devices arranged to direct at least part of the light radiation from each of the at least two illumination sources to the surface such that the at least part of the light radiation from each of the at least two illumination sources illuminates substantially the same area on the surface. The system also includes a sensor configured to receive light radiation from the at least two illumination sources reflected by the specimen and/or that pass by the specimen. The system also includes a power source configured to power the at least two illumination sources and the sensor.

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Номер записи: 26
27-09-2012 дата публикации

Microscope optical system

Номер: US20120243078A1
Автор: Kazuo Kajitani, Tatsuji Higuchi
Принадлежит: Olympus Corp

Observation over a superwide field of view is possible with a short, lightweight, and inexpensive eyepiece optical system and a binocular barrel. A microscope optical system includes an objective optical system configured to collect light from a specimen; an imaging optical system configured to image the light coming from the specimen and collected by the objective optical system; and an eyepiece optical system configured to magnify the image of the specimen formed by the imaging optical system and form a virtual image in an eye of an observer, wherein the following conditional expressions are satisfied, M=Fntl/Fob× 250/ Fne   (1) Fntl=Ftl×Kt   (2) Fne=Fe×Kt   (3) 0.4< Kt <0.95  (4)

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Номер записи: 27
18-10-2012 дата публикации

Through-the-lens illuminator for optical comparator

Номер: US20120262707A1
Автор: David E. Lawson, Stephanie Bloch
Принадлежит: Quality Vision International Inc

An illumination system shares portions of an objective of an optical inspection system. A plurality of beam-shaping optics collects light from a plurality of effective light sources and directs the light through a portion of the objective for illuminating an object under inspection. The objective includes a front relay lens, a rear relay lens, and an objective stop disposed between the front and rear relay lenses for collecting light scattered from the object and forming an image of the object with the collected light. The beam-shaping optics, which surround the objective stop, are arranged together with the associated effective light sources for non-uniformly distributing light within a range of angles required for illuminating the object.

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Номер записи: 28
08-11-2012 дата публикации

Tube lens, imaging optical system and microscope

Номер: US20120281082A1
Автор: Kenji Kawasaki
Принадлежит: Olympus Corp

A tube lens used in combination with an objective of the infinity correction type that enlarges the image of an object includes a first lens group including a cemented lens and having a positive power, a second lens group having a negative power, and a third lens group including a positive lens and a negative lens and having a positive power as a whole, in this order from the object side.

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Номер записи: 29
08-11-2012 дата публикации

Defect inspection device using catadioptric objective lens

Номер: US20120281207A1
Автор: Keiko YOSHIMIZU, Yasuhiro Yoshitake
Принадлежит: HITACHI LTD

A defect inspection device comprises an inspection optical system including a light source, a half mirror for reflecting illumination light emitted from the light source, a catadioptric objective lens for collecting reflected light from the sample by illumination light reflected by the half mirror, an imaging lens for focusing the reflected light transmitted through the catadioptric objective lens, a relay lens having a blocking member provided at a position at which specularly reflected light from the sample is focused by the imaging lens, and a detector for defecting the reflected light of the specularly deflected light blocked by the blocking member; and a computation processing unit for detecting defects of the sample on the basis of the signals detected by the detector.

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Номер записи: 30
08-11-2012 дата публикации

Handheld imaging probe

Номер: US20120281265A1
Автор: Ting Shen, Xiaojing Zhang, Youmin Wang
Принадлежит: Individual

A handheld imaging probe for performing optical coherence tomography is disclosed. The handheld imaging probe includes a lens tube and a housing. The lens tube contains an objective lens and a polycarbonate sheet. The polycarbonate sheet provides a bio-safe contact with a tissue sample to be examined. The housing, which is connected to the lens tube, contains a micromirror for directing a laser beam to irradiate the tissue sample via the objective lens and the polycarbonate sheet.

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Номер записи: 31
15-11-2012 дата публикации

Optical lens and optical microscope system using the same

Номер: US20120287500A1
Автор: Hsien-Wen Liu, Ming-Teng Hsieh, Yi-Nan Chen
Принадлежит: Nanya Technology Corp

An optical lens is provided in the present invention. The optical lens includes a first curved surface and an annular mask component on and in direct contact with the first curved surface, wherein the annular mask component shields a peripheral annular region of the optical lens from entry of light. The present invention further provides an optical microscope system using the same.

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Номер записи: 32
22-11-2012 дата публикации

Fluorescence collection objective optical system and method

Номер: US20120293863A1
Автор: Jesse McMullen, Warren Zipfel
Принадлежит: Individual

An optical system particularly suited for non-linear fluorescence collecting includes a front lens system, a rear lens system, and a bulk, dichroic beam splitting component intermediate the front lens system and the rear lens system to direct the fluorescent emission from a target object to a photodetector. A lens housing may have a reflective coating on an interior surface thereof. The objective optical system is particularly advantageous for use in cases where large fields of view and high collection efficiencies are desirable.

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Номер записи: 33
06-12-2012 дата публикации

Multi-Wavelength Multi-Lamp Radiation Sources and Systems and Apparatuses Incorporating Same

Номер: US20120307512A1
Автор: James Hermanowski, Jeffrey Cogger, Joel Melnick
Принадлежит: NATHANIEL GROUP Inc

Systems for providing high-intensity and high-quality illumination and other electromagnetic radiation (EMR) to target regions. The systems each include multiple EMR sources and a radiation combiner for combining the output radiation of the multiple sources. In some examples, the EMR sources are visible light sources, such as light-emitting diodes and laser diodes. In some of those examples, the light sources are of differing colors that are combined to form output illumination having user-selected qualities, such as color and intensity. The output of the radiation combiner can be directed into an optical fiber or bundle of optical fibers for remote delivery of the output to a target, such as in endoscopy and remote-illumination microscopy. Systems disclosed can also include additional EMR beams, such as visible light beams used for pointing/targeting and non-visible beams used, for example, for heating and fluoroscopic excitation of dyes/stains, among other things.

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Номер записи: 34
13-12-2012 дата публикации

Imaging system and techniques

Номер: US20120312957A1
Автор: Bikash Sabata, Chris Todd, Glenn Stark, Gregory L. LONEY
Принадлежит: BioImagene Inc, Ventana Medical Systems Inc

Systems and techniques for an optical scanning microscope and/or other appropriate imaging system includes components for scanning and collecting focused images of a tissue sample and/or other object disposed on a slide. The focusing system described herein provides for determining best focus for each snapshot as a snapshot is captured, which may be referred to as “on-the-fly focusing.” The devices and techniques provided herein lead to significant reductions in the time required for forming a digital image of an area in a pathology slide and provide for the creation of high quality digital images of a specimen at high throughput.

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Номер записи: 35
20-12-2012 дата публикации

Catadioptric system and image pickup apparatus

Номер: US20120320187A1
Автор: Kazuhiko Kajiyama, Masayuki Suzuki, Yuji Katashiba
Принадлежит: Canon Inc

The catadioptric system includes a first optical imaging system (catadioptric part) causing a light flux from an object to form an intermediate image and a second optical imaging system (dioptric part) causing the light flux from the intermediate image to form an image. In the first optical imaging system, the light flux sequentially passes a first transmissive portion, a second reflective portion, a first reflective portion and a second transmissive portion. In the second optical imaging system, consecutive four lens surfaces among plural lens surfaces placed between an aperture stop and an image surface have a negative combined refractive power, and a condition of −0.52<φ 4n — max ·Y max <−0.14 is satisfied, φ 4n — max represents a maximum value of the negative combined refractive power, and Y max represents a maximum object height in a field-of-view of the catadioptric system at the object.

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Номер записи: 36
10-01-2013 дата публикации

Microscope Objective

Номер: US20130010367A1
Автор: Stefan Schek
Принадлежит: Leica Microsystems CMS GmbH

Described is a microscope objective ( 10, 100, 200 ) having an objective housing ( 12 ) which contains a lens system including a lens unit ( 60 ) capable of being moved along the optical axis ( 0 ) of the lens system to compensate for the thickness of the coverslip, and further having an adjusting device for adjusting the lens unit ( 60 ), said adjusting device including a drive unit ( 14, 102, 202 ) and a transmission ( 42, 44, 46, 48, 50, 52, 54, 56, 62 ) which is drivable by the drive unit ( 14, 102, 202 ) and coupled to the lens unit ( 60 ). According to the present invention, the drive unit ( 14, 102, 202 ) has a motor ( 34 ) and is mounted on the objective housing ( 12 ).

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Номер записи: 37
17-01-2013 дата публикации

Microscope Device

Номер: US20130016204A1
Автор: Hakim El Haddouchi, Marc Hocke
Принадлежит: Leica Microsystems Schweiz AG

A microscope device ( 100 ) includes a surgical microscope ( 20 ), a camera ( 30 ), connected to the surgical microscope ( 20 ), for sensing an object ( 200 ) imaged by the surgical microscope, a stand ( 10 ) carrying the surgical microscope ( 20 ) as well as the camera ( 30 ), an operating unit ( 50 ), spatially separated from the camera ( 30 ), for controlling device functions of the camera ( 30 ). The operating unit ( 30 ) includes a screen ( 40 ) for displaying activatable device functions ( 51 ) and a selection and activation means, embodied as an actuatable rotary/push operating means ( 60 ), for selecting and activating one of the device functions displayed. The operating unit ( 50 ) is set up such that by rotating the rotary/push operating means ( 60 ), one ( 52 ) of the displayed device functions is selected, and by pushing the rotary/push operating means ( 60 ), the selected device function ( 52 ) is activated.

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Номер записи: 38
14-02-2013 дата публикации

Device and method for distributing illumination light and detected light in a microscope

Номер: US20130038875A1
Автор: Frank Schreiber
Принадлежит: Leica Microsystems CMS GmbH

A device for distributing illumination light and detected light in a microscope includes a distributor optic configured to guide illumination light onto a sample and guide detected light proceeding from the sample onto a detector. The distributor optic includes a polarization unit disposed in a first light path and configured to convert the illumination light directed onto the sample into a first polarization state, a beam splitter disposed in the first light path and having the polarization dependence so as to guide the converted illumination light onto the sample, a first portion of the detected light back into the first light path, and a second portion of the detected light into a second light path separated from the first light path. A beam combiner is configured to combine the first portion and the second portion of the detected light and guide the first portion and second portion onto the detector.

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Номер записи: 39
28-02-2013 дата публикации

Method for ascertaining material characteristics of an object

Номер: US20130050711A1
Автор: Thomas Ertl
Принадлежит: DeguDent GmbH

The invention relates to a method for ascertaining material characteristics of an object, in particular optical properties of preferably semi-transparent objects. The aim of the invention is to obtain material characteristics without complex measuring methods. This is achieved in that spectrally resolved data from measured data of the object are calculated with spectrally resolved data of a reference body in order to ascertain the material characteristics, the measured data being ascertained with a confocal 3D measuring system.

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Номер записи: 40
28-02-2013 дата публикации

Stereomicroscope

Номер: US20130050812A1
Автор: Chen Feng, Li Fan, Li Qian, Yu-Quan Wang
Принадлежит: Hon Hai Precision Industry Co Ltd, TSINGHUA UNIVERSITY

A stereomicroscope includes a base and a vessel which is disposed on the base. The vessel includes a transparent body and a light emitting unit. The transparent body has a bottom and a sidewall. The bottom and the sidewall define an opening. The sidewall extends from a side of the bottom. The opening of the transparent body places a specimen. The light emitting unit is fixed in the sidewall of the transparent body for emitting light. The light emitted from the light emitting unit illuminates the specimen, and is substantially parallel to the bottom of the transparent body.

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Номер записи: 41
14-03-2013 дата публикации

Catadioptric system and image pickup apparatus equipped with same

Номер: US20130063650A1
Автор: Kazuhiko Kajiyama, Masayuki Suzuki, Yuji Katashiba
Принадлежит: Canon Inc

A catadioptric unit includes, in order from an object side to an image side, a first optical element including a first transmissive unit having positive refractive power disposed in the vicinity of an optical axis and, on the object side thereof, a first reflective unit disposed at an outer circumference relative to the first transmissive unit and having a reflective surface; and a second optical element including a second transmissive unit having negative refractive power in the vicinity of the optical axis and, on the image side thereof, a second reflective unit disposed at an outer circumference relative to the second transmissive unit and having a reflective surface. Radii of curvature of object-side and image-side surfaces of the second optical element, a thickness along the optical axis and a refractive index of a material of the second optical element are set to satisfy predetermined conditions.

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Номер записи: 42
21-03-2013 дата публикации

Method for Generating a Microscope Image and Microscope

Номер: US20130068967A1
Автор: Kleppe Ingo, Novikau Yauheni
Принадлежит:

The invention relates to a method and a microscope for generating a microscopic image, wherein 1. Method for generating a microscope image , comprisinga) illuminating a specimen by way of a microscope objective lens by means of a TIRF methodandb) illuminating said specimen in a structured way in different shift positions of the structure,the specimen light of the method according to subparagraphs a) and b) hereof is detected in each instance in order to generate images of at least one specimen area, andwherein specimen images, generated according to paragraphs a) and b), are balanced relative to each other, preferably multiplied; and storing results in order to generate a new specimen image.2. Method for generating an image of a specimen claim 1 , according to claim 1 , by microscopy methods that provide different spatial resolutions claim 1 , wherein at least two of the following microscopy methods are combined:exciting said specimen to luminesce by structured line or wide field illumination in a first microscopy method; rotating and shifting said structuring several times for each rotational position; wherein at least three rotational positions and for each rotational position at least three shift positions are provided; imaging in each case the luminescent specimen onto a two-dimensional detector with a predetermined optical resolution; andfrom the resulting images a first microscopy image with a spatial resolution that is increased beyond the predetermined optical resolution is generated by a computational processing comprising a Fourier analysis;and in a second microscopy method the specimen is to be illuminated in such a tilted manner through the objective lens by way of a TIRF illumination module that total internal reflection takes place in a specimen arranged on the cover glass; and this total internal reflection is detected in a spatially resolving manner, and a second microscopy image is generated,wherein the first and second microscopy images are linked ...

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Номер записи: 43
28-03-2013 дата публикации

INVERTED MICROSCOPE

Номер: US20130075578A1
Автор: KITAHARA Akihiro
Принадлежит: OLYMPUS CORPORATION

An inverted microscope includes: a microscope main body; a stage that is supported by the microscope main body; and an observation optical system that allows observing a sample placed on the stage from underneath, the microscope main body, in which an optical device can be attached between an objective lens and a tube lens which constitute the observation optical system including a plurality of stage supporting parts that support the stage; and a beam part that connects, in a manner of locating between the tube lens and the objective lens, at least a pair of stage supporting parts at front and back sides together among the plurality of stage supporting parts. 1. An inverted microscope , comprising:a microscope main body;a stage that is supported by the microscope main body; and the microscope main body, in which an optical device can be attached between an objective lens and a tube lens which constitute the observation optical system includes', 'a plurality of stage supporting parts that support the stage; and', 'a beam part that connects, in a manner of locating between the tube lens and the objective lens, at least a pair of stage supporting parts at front and back sides together among the plurality of stage supporting parts., 'an observation optical system that allows observing a sample placed on the stage from underneath, wherein'}2. The inverted microscope according to claim 1 , comprising a focusing device at least a part of which is attached to one of the stage supporting parts and the beam part claim 1 , and which shifts the objective lens to an optical axis direction.3. The inverted microscope according to claim 2 , wherein the focusing device is an autofocusing device that detects a reflection light from one of the sample and a sample container and focuses the objective lens.4. The inverted microscope according to claim 1 , wherein the stage supporting parts includesa supporting part main body; anda sliding body that is formed together with the beam part ...

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Номер записи: 44
28-03-2013 дата публикации

Inverted microscope

Номер: US20130077158A1
Автор: Akihiro Kitahara, Mika Fukuda, Yusuke Matsumoto
Принадлежит: Olympus Corp

An inverted microscope includes: a stage which places a specimen thereon; a light source unit which has a light source irradiating light to the specimen on the stage; an objective lens which focuses at least observation light from the specimen on the stage; a body unit which holds at least the objective lens; a condenser which is provided on an optical axis of the objective lens; a condenser holding unit which holds the condenser; a condenser moving mechanism which movably supports the condenser holding unit and moves the condenser holding unit along the optical axis; a transmission mechanism which transmits power for moving the condenser to the condenser moving mechanism; and an input unit which inputs the power to the transmission mechanism. The input unit is provided above the condenser holding unit.

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Номер записи: 45
04-04-2013 дата публикации

Super-resolution observation aparatus

Номер: US20130083186A1
Автор: Shinichi Hayashi
Принадлежит: Olympus Corp

Super-resolution observation apparatus includes excitation light irradiation unit for irradiating excitation light intended to excite a sample on the sample, excitation light modulation unit for modulating a spatial intensity distribution of the excitation light on the sample, enlarged image forming unit for forming an enlarged image of the sample at an image position from observation light generated by irradiating the excitation light on the sample, image capturing unit for converting a spatial intensity distribution of the enlarged image into digital image data, and super-resolution processing unit for generating a super-resolution image where a super-resolution frequency component higher than a cutoff frequency of the enlarged image forming unit is made visible from one or a plurality of pieces of the digital image data. The super-resolution processing unit includes spatial frequency intensity modulation unit that change process contents according to an intensity level of a noise included in the digital image data.

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Номер записи: 46
11-04-2013 дата публикации

COMPOUND MICROSCOPE DEVICE

Номер: US20130088775A1
Автор: Arai Yoshihiro, Iijima Hirofumi, Nagayama Kuniaki, Terakawa Susumu
Принадлежит:

A compound microscope device allowing simultaneous observation of one specimen by a transmission electron microscope and an optical microscope, is provided. A compound microscope device of the present invention has a transmission electron microscope and an optical microscope A specimen and a reflection mirror are disposed on an electron optical axis C of an electron ray. The reflection mirror is inclined from the electron optical axis C toward the optical object lens and the specimen Light from the specimen (fluorescent light, reflection light, and the like) is reflected by the reflection mirror and entered into the optical object lens The electron ray from the electron microscope passes through a mounting center hole of the reflection mirror This makes it possible to observe one specimen simultaneously by the electron microscope and the optical microscope 111-. (canceled)12. A compound microscope device comprising:a transmission electron microscope including an electron gun that releases an electron ray toward a specimen, an electromagnetic object lens that images the electron ray, and a detection part into which the electron ray having passed through the electromagnetic object lens is entered;a fluorescent microscope including a light source that emits excitation light to irradiate the specimen, a light object lens that collects fluorescent light emitted from the specimen, and a light detection part into which the fluorescent light is entered; anda reflection mirror including a mounting center hole larger in diameter than a beam diameter of the electron ray, whereinthe electromagnetic object lens is formed by a cylindrical coil and a yoke covering the coil,the yoke has a notch constituting a pole piece,the reflection mirror is disposed on an electron-optical path between upper and lower poles of the pole piece,the electron ray passes through the mounting center hole of the reflection mirror,the excitation light is reflected by the reflection mirror toward the ...

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Номер записи: 47
11-04-2013 дата публикации

MICROSCOPE APPARATUS

Номер: US20130088776A1
Автор: Nakayama Hiroaki, Ouchi Yumiko
Принадлежит: NIKON CORPORATION

There is provided a microscope apparatus including: a plurality of objective lenses having different magnifications; an imaging system that receives light, which is generated from a sample and emitted from the objective lens when excitation light is emitted to a sample including a fluorescent material that is activated when irradiated with activation light having a predetermined wavelength and fluoresces to be inactivated when irradiated with excitation light having a different wavelength from the activation light in the activation state and that images the light in a state where an astigmatic difference is given to the image of the sample; and an imaging device that captures the image of the sample from the imaging system. The imaging system includes an astigmatic difference changing device that changes the astigmatic difference according to the depth of focus of the objective lens. 1. A microscope apparatus comprising:a plurality of objective lenses having different magnifications;an imaging system that receives fluorescence, which is emitted from a sample including a fluorescent material, through the objective lens and that forms an image of the sample to which an astigmatic difference is given; andan imaging device that captures the image of the sample from the imaging system,wherein the imaging system includes an astigmatic difference changing device that changes the astigmatic difference according to a depth of focus of the objective lens.2. The microscope apparatus according to claim 1 , further comprising:an irradiation device allowing light for activation to move toward the sample or allowing at least one of light for activation and light for excitation to move toward the sample.3. The microscope apparatus according to claim 1 ,wherein the astigmatic difference changing device includes a plurality of cylindrical lenses capable of giving different astigmatic differences to the image of the sample and a reciprocating section that moves the plurality of ...

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Номер записи: 48
11-04-2013 дата публикации

Retractable Beam Splitter for Microscope

Номер: US20130088777A1
Автор: BUTLER Jonathan Michael, HEWLETT Robert Jeffrey, HEWLETT Robert McCoy, HEWLETT Robert Troy
Принадлежит: Endure Medical, Inc.

Systems and methods are provided for illuminating a surface to be observed microscopically using a retractable beamsplitter. The retractable beamsplitter allows the use of coaxial illumination when the beamsplitter is positioned in the operator's line of sight. The retractable beamsplitter allows the use of non-coaxial illumination without reducing the amount of illumination that reaches the operator when the beamsplitter is retracted from the operator's line of sight. As a result a single system can be used effectively to provide various types of illumination. 1an objective lens,a retractable beam splitter positioned between the objective lens and the subject area, the retractable beam splitter having a deployed position intersecting the first observation path between the objective and the subject area, and a retracted position not intersecting the first observation path,wherein the retractable beam splitter in the deployed position is oriented to reflect a first primary illumination beam from the light source to the subject area and create a first reflected illumination beam that is coaxial with the first observation path.. An illumination system for a stereomicroscope, wherein the microscope comprises an objective lens is configured to permit observation of a subject at a subject area, and having a first observation path from the subject area to the objective lens, the illumination system comprising: This application is a continuation of U.S. application Ser. No. 13/216,178, filed on Aug. 23, 2011, which is currently pending. U.S. application Ser. No. 13/216,178 is a continuation-in-part of U.S. patent application Ser. No. 12/267,380, filed on Nov. 7, 2008, which was issued as U.S. Pat. No. 8,177,394 on May 15, 2012. The contents of U.S. application Ser. Nos. 13/216,178 and 12/267,380 are incorporated herein by reference in their entireties.The present disclosure is in the field of microscopes.This disclosure refers to various outside documents to aid the reader ...

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Номер записи: 49
18-04-2013 дата публикации

Omnidirectional super-resolution microscopy

Номер: US20130093871A1
Автор: Andreas G. Nowatzyk, Daniel FARKAS
Принадлежит: PHOTONANOSCOPY Inc

A microscopy method and apparatus includes placing a specimen to be observed adjacent to a reflective holographic optical element (RDOE). A beam of light that is at least partially coherent is focused on a region of the specimen. The beam forward propagates through the specimen and is at least partially reflected backward through the specimen. The backward reflected light interferes with the forward propagating light to provide a three dimensional interference pattern that is at least partially within the specimen. A specimen region illuminated by the interference pattern is imaged at an image detector. Computational reconstruction is used to generate a microscopic image in all three spatial dimensions (X,Y,Z), simultaneously with resolution greater than conventional microscopy.

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Номер записи: 50
18-04-2013 дата публикации

STRUCTURAL ILLUMINATION AND EVANESCENT COUPLING FOR THE EXTENSION OF IMAGING INTERFEROMETRIC MICROSCOPY

Номер: US20130094077A1
Автор: Brueck Steven R.J., Kuznetsova Yuliya, NEUMANN Alexander
Принадлежит: STC.UNM

In accordance with the aspects of the present disclosure, a method and apparatus is disclosed for imaging interferometric microscopy (IIM), which can use an immersion medium to enhance resolution up to a resolution of linear systems resolution limit of λ/4n, where λ is the wavelength in free space and n is the index of refraction of a transmission medium. 1. A method for microscopy comprising:{'sub': pp', 'pp, 'providing a plane-parallel optical element operable to be positioned adjacent to an object, wherein the plane-parallel optical element is characterized by a homogeneous refractive index (n) and a thickness (t), such that a distance of separation between the plane-parallel optical element and the object is within about a wavelength of illumination light incident upon the object;'}{'sub': 'pp', 'providing a first optical system disposed to provide a substantially coherent illumination of the object, wherein the illumination light is characterized by a wavelength λ, a radius of curvature, a center position, and a field-of-view and disposed at one of a plurality of incident wave vectors from about 0 to about 2πn/λ with respect to a surface normal of the plane-parallel optical element and at a plurality of azimuth angles spanning about 0 to 2π;'}providing a second optical system including one or more optical components defining an optical axis which is disposed on a side of the plane parallel optical element, the second optical system including a first set of optical media characterized by indices of refraction and thicknesses in which light scattered by the object propagates to the first optical component of the second optical system, an effective numerical aperture (NA) of the combined one or more optical components of the second optical system, a focal plane of the optical system conjugate with a image plane of an optical image recording device, and a field-of-view in the focal plane, wherein the optical axis of the second optical system is disposed at one of a ...

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Номер записи: 51
25-04-2013 дата публикации

Image Processing Apparatus And Image Processing Program

Номер: US20130100170A1
Автор: Shingo Matsumura, Woobum Kang
Принадлежит: Keyence Corp

Provided is an image processing apparatus and an image processing program which are capable of selectively and readily acquiring a geometrical physical quantity of a desired measuring portion. An object image is displayed based on object image data, and a measuring portion designating image corresponding to a specific portion of the object image is displayed based on designating image data. By operation of an operation part by a user, the displayed measuring portion designating image is moved relatively to the object image. When the measuring portion designating image is moved to a specific portion of the object image, a geometrical physical quantity of a measuring portion of the measuring object, previously set so as to correspond to that specific portion, is measured.

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Номер записи: 52
02-05-2013 дата публикации

Method and system for illuminating a sample

Номер: US20130107358A1
Автор: Frank Sieckmann, Werner Knebel
Принадлежит: Leica Microsystems CMS GmbH

A method for illuminating at least one sample in SPIM microscopy includes generating a light beam and forming a light strip from the light beam using an optical device that interacts with the light beam. The light strip is passed strip through at least one objective having optics configured to deliver detection light emanating from the sample directly or indirectly to a detector, with the objective optics interacting with the light strip. The light strip is deflected using a light-redirecting device downstream of the objective optics so as to propagate the light strip, after deflection, at an angle other than zero degrees with respect to an optical axis of the objective in order to illuminate the sample.

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Номер записи: 53
16-05-2013 дата публикации

MICROSCOPE SYSTEM

Номер: US20130120833A1
Автор: HIRANO Ryuichi, OBUCHI Hideki
Принадлежит: OLYMPUS CORPORATION

A microscope system includes a microscope body having a base portion forming a foundation, an arm portion extending substantially parallel to a bottom surface of the base portion, and a frame portion connecting ends of the base portion and the arm portion, having substantially a C shape in side view and holding an illumination optical system ejecting illumination light from a light source to a specimen. A light source unit is connected with the microscope body and radiates illumination light to the illumination optical system. A focusing unit supports a stage for placing the specimen and at least holding an objective lens focusing the specimen by collecting observation light from the specimen on the stage. The microscope body and the focusing unit do not contact each other in a state where an optical axis of the objective lens coincides with an optical axis of the illumination light. 1. A microscope system , comprising:a microscope body part including a base portion forming a foundation, an arm portion extending substantially parallel to a bottom surface of the base portion, and a frame portion connecting the ends of the base portion and the arm portion, the microscope body part having substantially a C shape in a side view and holding an illumination optical system ejecting illumination light from a light source to a specimen;a light source unit connected with the microscope body part and radiating the illumination light to the illumination optical system; anda focusing unit supporting a stage for placing the specimen and at least holding an objective lens focusing the specimen by collecting observation light from the specimen on the stage,wherein the microscope body part and the focusing unit do not contact each other in a state where an optical axis of the objective lens coincides with an optical axis of the illumination light.2. The microscope system according to claim 1 , wherein the focusing unit includes a condenser condensing the illumination light.3. The ...

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Номер записи: 54
16-05-2013 дата публикации

MICROSCOPE SYSTEM

Номер: US20130120834A1
Автор: SUKEKAWA Minoru
Принадлежит: OLYMPUS CORPORATION

A microscope system includes a stage on which a specimen is placed; an objective lens configured to condense at least observation light from the specimen on the stage; a transmitted illumination optical system configured to irradiate the specimen with transmitted illumination light ejected from a light source, which is illumination light transmitting the specimen; and a microscope body part including a base unit holding the transmitted illumination optical system, a supporting column standing upright from the base unit, and an incident-light illumination optical system provided on the end of a side different from the base unit side of the supporting column and irradiating the specimen with incident-light illumination light which is illumination light ejected from a light source to be reflected on the specimen, wherein the stage and the transmitted illumination optical system are attachable to/detachable from the microscope body part. 1. A microscope system comprising:a stage on which a specimen is placed;an objective lens configured to condense at least observation light from the specimen on the stage;a transmitted illumination optical system configured to irradiate the specimen with transmitted illumination light ejected from a light source, which is illumination light transmitting the specimen; anda microscope body part including a base unit holding the transmitted illumination optical system, a supporting column standing upright from the base unit, and an incident-light illumination optical system provided on the end of a side different from the base unit side of the supporting column and irradiating the specimen with incident-light illumination light which is illumination light ejected from a light source to be reflected on the specimen,wherein the stage and the transmitted illumination optical system are attachable to/detachable from the microscope body part.211a. The microscope system ( claim 1 , ) according to claim 1 , further comprising:{'b': 26', '22', '24 ...

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Номер записи: 55
23-05-2013 дата публикации

Inverted Microscope

Номер: US20130128345A1
Автор: Kajitani Kazuo
Принадлежит: OLYMPUS CORPORATION

Provided is an inverted microscope comprising an objective optical system that collects light from a specimen A; an image-forming optical system that images the light from the specimen A that has been collected by the objective optical system to form an intermediate image; a relay optical system that relays the intermediate image B of the specimen A formed by the image-forming optical system a binocular lens barrel that splits the light from the relay optical system a pair of ocular optical systems that image, in a magnified manner, the intermediate images that have been split by the binocular lens barrel on eyes E of an observer as virtual images; wherein the following conditional expressions are satisfied: 1. An inverted microscope comprising:an objective optical system that collects light from a specimen;an image-forming optical system that images the light from the specimen that has been collected by the objective optical system to form an intermediate image;a relay optical system that relays the intermediate image formed by the image-forming optical system;an light-splitting unit that splits the light from the relay optical system; anda pair of ocular optical systems that image, in a magnified manner, the intermediate images that have been split by the light-splitting unit on eyes of an observer as virtual images; [{'br': None, 'i': K', 'Fntl/Ftl', 'RL, '=()×β\u2003\u2003(1),'}, {'br': None, 'i': 'Fne=Fe×K', '(2), and'}, {'br': None, '0.3 Подробнее

Номер записи: 56
23-05-2013 дата публикации

MICROSCOPE DEVICE

Номер: US20130128346A1
Автор: SANGUU Hiroyuki
Принадлежит: YOKOGAWA ELECTRIC CORPORATION

A microscope device according to the present disclosure (the present microscope device) includes: a light source configured to oscillate coherent illuminating light, the illuminating light being applied on a specimen; a detecting unit configured to detect fluorescent light from the specimen as feedback light, the specimen being irradiated with the illuminating light; a phase distribution control unit disposed in an optical path of the illuminating light, the phase distribution control unit being configured to control phase distribution of the illuminating light; a controller configured to control the phase distribution control unit to vary the phase distribution; and an image generating unit configured to operate a difference of the feedback light between before and after the phase distribution varies, to generate an image of the specimen. 1. A microscope device comprising:a light source configured to oscillate a coherent illuminating light, the illuminating light being applied on a specimen;a detecting unit configured to detect a fluorescent light from the specimen as a feedback light, the specimen being irradiated with the illuminating light;a phase distribution control unit disposed in an optical path of the illuminating light, the phase distribution control unit being configured to control a phase distribution of the illuminating light;a controller configured to control the phase distribution control unit to vary the phase distribution; andan image generating unit configured to operate a difference of the feedback light between before and after the phase distribution varies, to generate an image of the specimen.2. The microscope device according to claim 1 , wherein perform a first control that controls the phase distribution control unit such that almost a whole illuminating light has a uniform phase; and', 'perform a second control that controls the phase distribution control unit such that the illuminating light has a phase distribution where rays of the ...

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Номер записи: 57
30-05-2013 дата публикации

Chemical mapping using thermal microscopy at the micro and nano scales

Номер: US20130134310A1
Автор: Chris Kendziora, Nabil D. Bassim, Robert Andrew Mcgill, Robert Furstenberg, Viet K. Nguyen
Принадлежит: Chris Kendziora, Nabil D. Bassim, Robert Andrew Mcgill, Robert Furstenberg, Viet K. Nguyen

A non-destructive method for chemical imaging with ˜1 nm to 10 μm spatial resolution (depending on the type of heat source) without sample preparation and in a non-contact manner. In one embodiment, a sample undergoes photo-thermal heating using an IR laser and the resulting increase in thermal emissions is measured with either an IR detector or a laser probe having a visible laser reflected from the sample. In another embodiment, the infrared laser is replaced with a focused electron or ion source while the thermal emission is collected in the same manner as with the infrared heating. The achievable spatial resolution of this embodiment is in the 1-50 nm range.

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Номер записи: 58
30-05-2013 дата публикации

CHROMATIC CONFOCAL MICROSCOPE SYSTEM AND SIGNAL PROCESS METHOD OF THE SAME

Номер: US20130135715A1
Автор: Chang Yi-Wei, CHEN LIANG-CHIA
Принадлежит: NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY

A chromatic confocal microscope system and signal process method is provided to utilize a first optical fiber module for modulating a light into a detecting light passing through a chromatic dispersion objective and thereby forming a plurality of chromatic dispersion lights to project onto an object. A second optical fiber module conjugated with the first optical fiber module receives a reflected object light for forming a filtered light, which is split into two filtered lights detected by two color sensing units for generating two sets of RGB intensity signals, wherein one set of RGB intensity signals is adjusted relative to the other set of RGB intensity signals. Then two sets of RGB intensity signals are calculated for obtaining a maximum ratio factor. Finally, according to the maximum ratio factor and a depth relation curve, the surface profile of the object can be reconstructed. 1. A chromatic confocal microscope system , comprising:a light source module, providing a linear/planar detecting light;a chromatic dispersion objective, axially dispersing the linear/planar detecting light thereby forming a plurality of sub lights respectively having a focal depth different from each other, and projecting the plurality of sub lights on an object for forming a linear/planar object light;an optical module, splitting the linear/planar object light into a first object light having a first focal point and a second object light having a second focal point; anda pair of color sensing units, respectively receiving the first object light at a first position and the second object light at a second position for respectively generating a plurality sets of first RGB intensity signals and a plurality sets of second RGB intensity signals having an offset from the plurality sets of first RGB intensity signals, wherein each set of first and second RGB intensity signals are corresponding to each inspection position on a surface receiving the linear/planar detecting light of the object, ...

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Номер записи: 59
30-05-2013 дата публикации

OPTICAL MEMBER AND MICROSCOPE

Номер: US20130135716A1
Автор: HAGIWARA Mayumi, SATAKA Ryoichi
Принадлежит: NIKON CORPORATION

An optical member and a microscope that allow acquiring brighter and sharper images when fluorescent observation is performed while stimulating a sample with light. Illumination light from a laser unit is split into stimulation light and excitation light by a dichroic mirror. In other words, half of the illumination light is transmitted through the dichroic mirror and becomes the stimulation light, and half of the illumination light is reflected by the dichroic mirror and becomes the excitation light. Half of the excitation light is reflected by a dichroic mirror and is irradiated onto a sample, and half of the stimulation light transmits through the dichroic mirror and is irradiated onto the sample. Fluorescence generated from the sample is totally reflected by the dichroic mirror and the dichroic mirror, and is received by a photodetector. 18-. (canceled)9. A microscope comprising:a first optical member that reflects a part of stimulation light used for stimulating a sample and a part of excitation light having a same wavelength as the stimulation light, which used for generating fluorescence from the sample, and that transmits a part of the stimulation light and a part of the excitation light, to thereby guide, to an objective lens, the stimulation light and the excitation light entering from mutually different directions, irradiates the stimulation light and the excitation light onto the sample via the objective lens, and reflects or transmits approximately all of the fluorescence generated by irradiating the excitation light onto the sample;a first scanning unit that scans the sample with the stimulation light by deflecting the stimulation light;a second scanning unit that scans the sample with the excitation light by deflecting the excitation light; anda second optical member that reflects a part of incident light having a predetermined wavelength and transmits a part of the incident light, to thereby separate the incident light into the stimulation light and ...

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Номер записи: 60
30-05-2013 дата публикации

Microscope Illumination System and Method

Номер: US20130135717A1
Автор: Schulz Christian
Принадлежит: Leica Microsystems CMS GmbH

The present invention relates to a microscope illumination system for switching between a first, confocal and a second, non-confocal microscope illumination mode, the system having an illumination unit that, in order to provide the first illumination mode, includes an illumination source for generating an illumination beam propagating parallel to the optical axis; a scanning mirror for deflecting the illumination beam perpendicular to the optical axis; and a scanning eyepiece and a downstream scanning tube lens for imaging the scanning mirror into the back focal plane of a microscope objective and for expanding the illumination beam, the objective focusing the illumination beam onto a specimen to be examined. In order to provide the second illumination mode, the system has a focusing lens inserted into the path of the illumination beam in such a way that the illumination beam is focused into the back focal plane of the microscope objective. 1. A microscope illumination system for switching between a first and a second microscope illumination mode , the microscope illumination system having a microscope illumination unit which , in order to provide the first microscope illumination mode , includes:an illumination source device for generating an illumination beam that propagates parallel to the optical axis,a scanning mirror device for deflecting the illumination beam in a plane perpendicular to the optical axis,a scanning eyepiece and a downstream scanning tube lens for imaging the scanning mirror device into the back focal plane of a microscope objective and for expanding the illumination beam, the microscope objective focusing the illumination beam onto a specimen to be examined,wherein, in order to provide the second microscopy illumination mode, the microscope illumination unit has a focusing lens which can be inserted into the path of the illumination beam in such a way that the illumination beam is focused into the back focal plane of the microscope objective.2 ...

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Номер записи: 61
30-05-2013 дата публикации

MICROSCOPE OBJECTIVE LENS

Номер: US20130135739A1
Автор: TAKASAGO Kazuhiro, TOSHI Taeko
Принадлежит: NIKON CORPORATION

Provided is a microscope objective lens that sufficiently corrects on-axis and off-axis chromatic aberrations and that has a long working distance. A microscope objective lens OL includes, in order from an object side, a first lens group G with positive refractive power and a second lens group G with negative refractive power. The first lens group G of the microscope objective lens OL includes a diffractive optical element GD including a diffractive optical surface D, and the diffractive optical element GD is arranged at a position closer to the image than a section where a diameter of a light flux passing through the first lens group G is the largest. 1. A microscope objective lens comprising , in order from an object side:a first lens group with positive refractive power; anda second lens group with negative refractive power, whereinthe first lens group comprises a diffractive optical element including a diffractive optical surface,the diffractive optical element is arranged at a position closer to an image than a position where a diameter of a light flux passing through the first lens group is the largest, and{'b': '2', 'claim-text': [{'br': None, 'φDOE/φmax<0.76'}, {'br': None, 'i': f', 'f<, '0.65<(−2)/2.0.'}], 'conditions of the following expressions are satisfied, in which a maximum diameter of the light flux passing through the first lens group is defined as φmax, a maximum diameter of the light flux passing through the diffractive optical surface is defined as φDOE, a focal length of the second lens group is defined as f, and a focal length of an entire system is defined as f2. The microscope objective lens according to claim 1 , whereinthe first lens group comprises a lens component with positive refractive power arranged closest to an object, and{'b': '0', 'claim-text': {'br': None, 'i': Подробнее

Номер записи: 62
06-06-2013 дата публикации

Method of detecting an acceleration

Номер: US20130141729A1
Автор: Gordon S. Kino, Michel J.F. Digonnet, Olav Solgaard, Onur Kilic
Принадлежит: Leland Stanford Junior University

A method detects an acceleration. The method includes providing a spatial mode filter positioned such that light emitted from the spatial mode filter is reflected by at least a portion of a reflective surface. The spatial mode filter and the portion of the reflective surface form an optical resonator having an optical resonance with a resonance lineshape. The method further includes emitting light from the spatial mode filter and irradiating the portion of the reflective surface. The portion of the reflective surface is responsive to acceleration of the optical resonator by changing curvature. The method further includes measuring a change of the resonance lineshape due to the acceleration of the optical resonator.

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Номер записи: 63
06-06-2013 дата публикации

TUNABLE ACOUSTIC GRADIENT INDEX OF REFRACTION LENS AND SYSTEM

Номер: US20130141782A1
Автор: Arnold Craig B., Theriault Christian
Принадлежит:

A microscope, comprising a stage onto which is placed an item, a lens having a tunable acoustic gradient index of refraction (TAG lens) sufficiently proximate to said stage to magnify an image of the item, a viewing point for providing for viewing of the magnified image, and a pulsed illuminator capable of illuminating the stage and synchronously pulsed with an operating frequency of the TAG lens. 1. A microscope , comprising:a stage onto which is placed an item;a tunable acoustic gradient index of refraction (TAG) lens sufficiently proximate to said stage to magnify an image of the item;a viewing point for providing for viewing of the magnified image; andan pulsed illuminator capable of illuminating said stage and synchronously pulsed with an operating frequency of said TAG lens.2. A tunable acoustic gradient index of refraction lens , comprising:a casing having a cavity disposed therein for containing a refractive fluid capable of changing its refractive index in response to application of an acoustic wave;at least one compressible component disposed in the cavity for modifying the change in the refractive index of the refractive fluid.3. A device for providing modified performance responsive to pressure changes , comprising:a closed, sealed cavity;a fluid in said cavity for providing the modified performance responsive to the pressure changes; anda relief bubble comprised of air, wherein said relief bubble at least buffers the pressure changes in relation to the closed, sealed cavity. The present invention relates generally to a tunable acoustic gradient index of refraction (TAG) lens, and more particularly, but not exclusively, to a TAG lens that is configured to permit dynamic focusing and imaging.When it comes to shaping the intensity patterns, wavefronts of light, or position of an image plane or focus, fixed lenses are convenient, but often the need for frequent reshaping requires adaptive optical elements. Nonetheless, people typically settle for whatever ...

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Номер записи: 64
13-06-2013 дата публикации

Light-emitting diode architectures for enhanced performance

Номер: US20130146932A1
Автор: Andrei Kazmierski, Donald L. Mcdaniel, Jr., Michael Gregory Brown, Michael Lim, Scott W. Duncan
Принадлежит: Luminus Devices Inc

The present invention relates to light-emitting diodes (LEDs), and related components, processes, systems, and methods. In certain embodiments, an LED that provides improved optical and thermal efficiency when used in optical systems with a non-rectangular input aperture (e.g., a circular aperture) is described. In some embodiments, the emission surface of the LED and/or an emitter output aperture can be shaped (e.g., in a non-rectangular shape) such that enhanced optical and thermal efficiencies are achieved. In addition, in some embodiments, chip designs and processes that may be employed in order to produce such devices are described.

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Номер записи: 65
13-06-2013 дата публикации

CELL COUNTER AND METHOD OF MANUFACTURING THE SAME

Номер: US20130147940A1
Автор: CHO Keunchang, Jung Neon Cheol, Lim Hyun Chang
Принадлежит: Logos Biosystems, Inc.

A cell counter includes: a sample slide configured to accommodate cells; a housing configured to be inserted into the inside of the sample slide from the outside of the sample slide; an object lens configured to be mounted within the housing, and to image-form a cell image for the cells projected from the sample slide; an image acquisition unit configured to be mounted within the housing together with the object lens, and to acquire the cell image image-formed by the object lens; and a first reflecting mirror provided between the sample slide and the object lens within the housing, and configured to change a projection direction of the cell image projected from the sample slide to the object lens. 1. A cell counter comprising:a sample slide configured to accommodate cells;a housing configured that the sample slide is inserted into an inside of the housing from an outside of the housing;an object lens configured to be mounted within the housing, and to image-form a cell image for the cells projected from the sample slide;an image acquisition unit configured to be mounted within the housing together with the object lens, and to acquire the cell image image-formed by the object lens; anda first reflecting mirror provided between the sample slide and the object lens within the housing, and configured to change a projection direction of the cell image projected from the sample slide to the object lens.2. The cell counter of claim 1 , wherein first reflecting mirror changes the projection direction of the object lens projected to the object lens in such a manner that the height of the housing is not limited by the arrangement of the object lens and the image acquisition unit.3. The cell counter of claim 2 , wherein the object lens and the image acquisition unit are arranged on a virtual plane that is parallel to a virtual plane where the sample slide is arranged after being inserted into the inside of the housing.4. The cell counter of claim 2 , wherein the height of the ...

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Номер записи: 66
13-06-2013 дата публикации

LASER-SCANNING MICROSCOPE SYSTEM

Номер: US20130147941A1
Автор: Okada Junichi
Принадлежит: OLYMPUS CORPORATION

Repeatability of control items is ensured by improving the precision of time control, and control details for the control items can be changed even when observation is underway. Provided is a laser-scanning microscope system including a microscope apparatus that scans a specimen surface with laser light from a laser light source by using a scanner; a hardware sequencer that controls the microscope apparatus so as to execute a control item that is set in an application program in correspondence with a time axis; and a software sequencer that manages control details for the control item that is set in the application program. 1. A laser-scanning microscope system comprising:a microscope apparatus that scans a specimen surface with laser light from a laser light source by using a scanner;a hardware sequencer that controls the microscope apparatus so as to execute a control item that is set in an application program in correspondence with a time axis; anda software sequencer that manages control details for the control item that is set in the application program.2. A laser-scanning microscope system according to claim 1 , wherein the hardware sequencer controls an execution time of the control item and a scanning mode of the scanner claim 1 , andthe software sequencer manages a condition and a sequence of the control item.3. A laser-scanning microscope system according to claim 1 , wherein the hardware sequencer generates an interrupt to the software sequencer just before a starting time of the control item claim 1 , andthe software sequencer is capable of changing the control item until the starting time by means of the hardware sequencer.4. A laser-scanning microscope system according to claim 3 , wherein the hardware sequencer includes a timer claim 3 , which manages the starting time of the control item claim 3 , and outputs an interrupt to the software sequencer at a predetermined period of time before the starting time claim 3 , andthe software sequencer sends a ...

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Номер записи: 67
13-06-2013 дата публикации

CONFOCAL OPTICAL SCANNER AND CONFOCAL MICROSCOPE

Номер: US20130148184A1
Автор: AZUMA Takuya
Принадлежит: YOKOGAWA ELECTRIC CORPORATION

A confocal optical scanner includes: a plurality of condenser elements each configured to concentrate illumination light to be applied on a sample to produce fluorescence from the sample; a plurality of optical scanning units including a plurality of openings each configured to allow the illumination light concentrated by the condenser element to pass the opening, the optical scanning units each configured to scan the sample with the illumination light that has passed through the opening; a moving mechanism configured to move the optical scanning units to select one of the optical scanning units; and an incident-angle adjusting part configured to adjust the incident angle of the illumination light incident on the optical scanning unit selected from the optical scanning units according to the selected optical scanning unit. 1. A confocal optical scanner comprising:a plurality of condenser elements each configured to concentrate illumination light to be applied on a sample to produce fluorescence from the sample;a plurality of optical scanning units including a plurality of openings each configured to allow the illumination light concentrated by the condenser element to pass through the opening, the optical scanning units each configured to scan the sample with the illumination light that has passed through the opening;a moving mechanism configured to move the optical scanning units to select one of the optical scanning units; andan incident-angle adjusting part configured to adjust an incident angle of the illumination light incident on the optical scanning unit selected from the optical scanning units according to the selected optical scanning unit.2. The confocal optical scanner according to claim 1 , further comprising:a reflective mirror provided for each of the optical scanning units, where the reflective minor is secured on the moving mechanism and configured to reflect the illumination light to the optical scanning unit; anda mirror adjusting part provided for ...

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Номер записи: 68
13-06-2013 дата публикации

Microscope with tunable acoustic gradient index of refraction lens enabling multiple focal plan imaging

Номер: US20130148196A1
Автор: Craig B. Arnold
Принадлежит: Craig B. Arnold

An apparatus, system and method for microscopy. The apparatus, system and method includes a stage configured to receive an item; a tunable acoustic gradient index of refraction (TAG) lens having a first aspect positioned to image the received item, wherein the first aspect of the TAG lens is configured to have an optical power profile in accordance with an operational frequency of the TAG lens; one or more lenses configured to magnify an image of the received item at a viewing point; and at least one pulsed light source configured to illuminate the received item and to pulse at one or more points within the optical power profile of the TAG lens.

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Номер записи: 69
13-06-2013 дата публикации

MICROSCOPE OBJECTIVE LENS

Номер: US20130148202A1
Автор: YOSHIDA Miwako
Принадлежит: NIKON CORPORATION

A microscope objective lens includes, in order from an object side, a first lens group having positive refractive power, a second lens group having positive refractive power, and a third lens group having negative refractive power, and is configured such that the first lens group includes, on the most object side, a positive meniscus lens whose concave surface is directed to the object side, such that the second lens group includes a diffractive optical element having positive refractive power, and such that the diffractive optical element is arranged at a position closer to the image than a portion at which the diameter of a light flux passing through the first lens group and the second lens group is the largest. 1. A microscope objective lens comprising , in order from an object side ,a first lens group having positive refractive power,a second lens group having positive refractive power, anda third lens group having negative refractive power, whereinthe first lens group includes, on the most object side, a positive meniscus lens whose concave surface is directed to the object side,the second lens group includes a diffractive optical element having positive refractive power, andthe diffractive optical element is arranged at a position closer to the image than a portion at which the diameter of a light flux passing through the first lens group and the second lens group is the largest, [{'br': None, 'i': 'n', '1≧1.8'}, {'br': None, 'i': r', 'F≦, '0.5≦(−1)/4.5'}, {'br': None, 'ΦDOE/Φmax<0.9'}], 'the microscope objective lens satisfying the following expressionswhere a refractive index relative to a d-line of a medium of the positive meniscus lens included in the first lens group is set as n1, a radius of curvature of the most object side lens surface of the first lens group is set as r1, a focal length of the whole lens system is set as F, the maximum diameter of the light flux passing through the first lens group and the second lens group is set as Φmax, and the ...

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Номер записи: 70
20-06-2013 дата публикации

Pathology Slide Scanner

Номер: US20130155499A1
Автор: Dixon Arthur Edward
Принадлежит:

An instrument and method for scanning at least a portion of a large specimen preferably causes the specimen to move relative to a two-dimensional detector array at a constant speed. The detector array takes one image of the specimen for each line that the detector moves. A controller controls a shutter of the detector array to open to take images and to pass the images to a processor, which is preferably a computer. The instrument takes one partial image of each part of the specimen that is being scanned and then combines those images with other images to produce a contiguous image. 1. An instrument for scanning at least a portion of a large specimen , said instrument comprising an imaging system having an optical train to focus light from the specimen onto a two dimensional detector array , said detector array being part of the optical train , said specimen being supported on a specimen holder , said holder being movable relative to said detector array in a direction perpendicular to and edge dimension of said detector array and perpendicular to an optical train of the instrument , said specimen moving with said holder , said detector array being configured to receive data from said specimen through said imaging system when a shutter of said detector array is open and to pass data to a processor when said shutter is closed , said shutter being controllable by a controller to open and close as said holder moves relative to said detector array and said optical train , said detector array having N lines a distance X apart , said stage and said specimen being movable relative to said detector array by successive distances of X on said detector and corresponding distances of Y on said specimen , said shutter being controllable by a controller to open briefly and to close within each incremental distance X said detector array moves relative to said specimen , said shutter being controllable to repeatedly open and close numerous times for each image strip taken of said ...

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Номер записи: 71
20-06-2013 дата публикации

LASER SCAN CONFOCAL MICROSCOPE

Номер: US20130155500A1
Автор: AIKAWA Naoshi, Yoshida Yuki
Принадлежит: NIKON CORPORATION

Fluorescence is generated from an irradiated point on an inspection surface of a sample and the fluorescence is collected by an objective lens. Here, because of the magnification chromatic aberration of the objective lens , the fluorescence going out from the objective lens travels along a path shifted from the irradiation light and changed substantially into a non-scan light by a galvano-scanner. The fluorescence passes through a dichroic mirror and comes into deflection means as 2-dimensional deflection means after light of unnecessary wavelength is removed by a filter. The deflection means is driven in synchronization with the galvano-scanner by a computer and corrects the shift and inclination of the optical axis generated by the magnification chromatic aberration of the objective lens. After the shift and inclination of the optical axis are corrected, the fluorescence forms an image of the irradiation point of the inspection surface of the sample on a pin hole of a pin hole plate by using a collective lens. Thus, it is possible to provide a laser scan confocal microscope capable of correcting the peripheral light reduced by the magnification chromatic aberration by using an optical system even if the used objective lens has the magnification chromatic aberration. 1. A laser scan confocal microscope comprising:a light separator that is configured to separate illumination light of a light source and observation light, the observation light being emitted from a specimen;a light scanner that is configured to scan the illumination light on the specimen;an objective lens that is configured to be disposed between the light scanner and the specimen to form a focal point on the specimen;a collective lens that is configured to collect the observation light to a position conjugate to the focal point of the objective lens;a pinhole plate which is provided in a focal plane of the collective lens;a detector that is configured to detect observation light having passed through ...

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Номер записи: 72
27-06-2013 дата публикации

Imaging and evaluating embryos, oocytes, and stem cells

Номер: US20130162795A1
Автор: Barry Behr, Connie C. Wong, Kevin E. Loewke, Renee A. Reijo-Pera, Thomas M. Baer
Принадлежит: Leland Stanford Junior University

Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.

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Номер записи: 73
27-06-2013 дата публикации

Method and Apparatus For Automatic Focusing of Substrates in Flourescence Microscopy

Номер: US20130162804A1
Автор: Morrin Markus
Принадлежит:

An apparatus for automated examination of biological material () includes a microscope () with a cross table () with the biological material () being arranged on the cross table () between an object slide () or an analysis plate and a cover (); a light source (); an evaluation unit; a device for automatic focusing (); an image recording unit () for recording an image of the biological material () enlarged via of an object lens () of the microscope () and for transferring the image to the evaluation unit; and a biochip (). Labeling () is provided on a surface of the biochip (). Focusing is executable by targeted movement of the cross table () based on detection of the labeling (), and a target interval is determinable by determination of a location and/or a position of the labeling, within which focusing of the biological material takes place. 120-. (canceled)21. An apparatus for automated examination of biological material , comprising:a microscope with a cross table, wherein said biological material is arranged on said cross table between an object slide or an analysis plate and at least one cover;at least one light source for exposure of said biological material;an evaluation unit;a device for automatic focusing; andan image recording unit adapted to record at least one image of said biological material enlarged by means of an object lens of said microscope and to transfer said at least one image to the evaluation unit;a biochip, wherein said biological material is arranged on the biochip, wherein said biochip is manufactured by fragmentation and division of a cover slip, wherein said biochip is applied to said object slide;labeling provided on a surface of said biochip, wherein said labeling is detectable by the device for automatic focusing of said biological material, and wherein said focusing is executable by targeted movement of said cross table based on detection of said labeling, wherein a target interval is determinable by determination of a location and/ ...

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Номер записи: 74
27-06-2013 дата публикации

TRANSMISSION INTERFERENCE MICROSCOPE

Номер: US20130163076A1
Автор: Nagaoki Isao, Tanigaki Toshiaki
Принадлежит:

Disclosed is a transmission interference microscope that provides a degree of freedom to a region being observed while obtaining pure transmission information, and obtains highly-accurate interference images at high magnification under optimized radiation conditions. An electron beam emitted from an electron source is split by a biprism positioned under a converging lens and enters objective lenses as an electron beam passing through a sample and an electron beam passing through a vacuum. The electron beams are bent at the front magnetic fields of the objective lenses and are emitted as a collimated beam in a state in which the sample location and vacuum are each appropriately are left a space. 1. A transmission interference microscope comprising: a light source of a charged particle beam; an irradiation optical system configured to irradiate an electron beam emitted from the light source to a sample; an irradiation system biprism provided between the light source and the sample , the irradiation system configured to irradiate the respective split electron beams to a sample location and a vacuum location on a level of the sample; a mechanism configured to hold the sample; an imaging lens system configured to form an image of the sample; at least one stage of an imaging system biprism provided in the imaging lens system; and a device configured to observe or record interference fringes of the electron beam passing through the vacuum location and the electron beam passing through the sample location on the level of the sample.2. The transmission interference microscope according to claim 1 , wherein the microscope is provided with an objective aperture having two apertures3. The transmission interference microscope according to claim 1 , wherein the microscope has a function of rotating the biprisms around a light axis claim 1 , coordinating with an irradiation system lens current.4. The transmission interference microscope according to claim 1 , wherein the ...

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Номер записи: 75
04-07-2013 дата публикации

Imaging apparatus

Номер: US20130169859A1
Автор: Tomoaki Kawakami, Toshihiko Tsuji
Принадлежит: Canon Inc

An imaging apparatus ( 1 ) includes an illumination optical system ( 100 ) that includes a light source ( 110 ) and is configured to guide light from the light source to a target (B), an imaging optical system configured to capture an image of the target, and a plurality of image sensors ( 430 ) arranged on an image plane of the imaging optical system. The illumination optical system includes a plurality of integrators ( 121,122 ). Light flux exits from one of the plurality of integrators illuminates at least one of the plurality of image sensors, and light exits from the other integrators illuminates at least one of the plurality of image sensors other than the image sensor illuminated by the light exits from the one of the plurality of integrators.

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Номер записи: 76
04-07-2013 дата публикации

MICROSCOPE OPTICAL SYSTEM AND MICROSCOPE SYSTEM

Номер: US20130170021A1
Автор: MUKAI Kaori, YOSHIDA Miwako
Принадлежит: NIKON CORPORATION

Provided is a microscope optical system in which the occurrence of flare due to unnecessary-order diffracted light exited from a diffractive optical element is suppressed. A microscope objective lens MS is configured by including an objective lens OL which has a diffractive optical element GD and converts light from an object into a substantially parallel light flux, and a second objective lens IL which forms an image of the object by focusing the substantially parallel light flux from the objective lens OL, and is configured such that, in case where an m-th order of diffracted light from the diffractive optical element GD is used for the image formation, the following expression is satisfied: |θ|>tan(0.06/0) when the light of a maximum NA emitted from the object located on an optical axis enters the diffractive optical element. 1. A microscope optical system comprising: an objective lens which has a diffractive optical element and converts light from an object into a substantially parallel light flux; and a second objective lens which forms an image of the object by focusing the substantially parallel light flux from the objective lens , wherein {'br': None, 'sup': '−1', '|θ|>tan(0.06/D)\u2003\u2003[Expression 10]'}, 'in case where an m-th order diffracted light from the diffractive optical element is used for the image formation, the following expression is satisfiedwhen the light of a maximum NA emitted from the object located on an optical axis enters the diffractive optical element, where θ is the incident angle on the second objective lens of the diffracted light having an order of diffraction different from the order of the m-th order diffracted light from the diffractive optical element, and D [mm] is a diameter of an entrance pupil to the second objective lens.3. The microscope optical system according to claim 1 , wherein the diffractive optical element is a contact multi-layered diffractive optical element.4. The microscope optical system according to ...

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Номер записи: 77
04-07-2013 дата публикации

Device for Continuous Adjustment of Spectrometer Gap Widths

Номер: US20130170023A1
Автор: BORLINGHAUS Rolf, STEINMETZ Irmtraud
Принадлежит: Leica Microsystems CMS GmbH

A microscope () has an aperture arrangement () that, in order to limit the dimension of a light beam (), comprises an aperture opening (). The size of the aperture opening () is adjustable with the aid of a first aperture member () and a second aperture member (). At least one of the two aperture members () is movable relative to the other aperture member (). The aperture members () are spaced apart from one another when the aperture opening () is closed. 110294137323432343234. A microscope () having an aperture arrangement () that , in order to limit the dimension of a light beam () , comprises an aperture opening () whose size is adjustable with the aid of a first aperture member () and a second aperture member () , at least one of the two aperture members ( , ) being movable relative to the other aperture member ( , ) ,{'b': 32', '34', '37, 'wherein the aperture members (, ) are spaced apart from one another when the aperture opening () is closed.'}210323441. The microscope () according to claim 1 , in which the two aperture members ( claim 1 , ) are arranged with an offset from one another in the axial direction of the light beam () to be limited.310373943323441. The microscope () according to claim 1 , in which claim 1 , when the aperture opening () is closed claim 1 , aperture edges ( claim 1 , ) of the aperture members ( claim 1 , ) are arranged with an offset from one another in the axial direction of the light beam () to be limited.41032343335414137. The microscope () according to claim 1 , in which one side of at least one of the aperture members ( claim 1 , ) comprises a reflective region ( claim 1 , ) that reflects a portion of the light beam () claim 1 , such that another portion of the light beam () passes through the aperture opening ().5103732344241. The microscope () according to claim 1 , in which claim 1 , for adjustment of the size of the aperture opening () claim 1 , at least one of the aperture members ( claim 1 , ) is movable in a direction ...

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Номер записи: 78
04-07-2013 дата публикации

Oblique-illumination systems and methods

Номер: US20130170024A1
Автор: Carl Brown, Kyla TEPLITZ
Принадлежит: Applied Precision Inc

Oblique-illumination systems integrated with fluorescence microscopes and methods of using oblique illumination in fluorescence microscopy are disclosed. An oblique-illumination system is attached to a fluorescence microscope objective. The oblique-illumination system can be used to illuminate from any desired direction the surface of an object located at a fixed known offset away from a sample solution containing fluorescently tagged targets. Oblique illumination is used to illuminate features of the surface while epi-illumination is used to create fluorescent light emitted from the tagged targets. The combination of oblique illumination of the surface and epi-illumination of the targets enables capture of images of the surface features and the fluorescent targets so that the locations of the targets in the sample can be determined based on the locations of the surface features.

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Номер записи: 79
11-07-2013 дата публикации

MICROSCOPE SYSTEM AND AUTOFOCUS METHOD

Номер: US20130176617A1
Автор: TAMURA Yosuke
Принадлежит: OLYMPUS CORPORATION

A microscope system and an autofocus method capture a subject at a specified time interval through an optical image forming system while relatively moving a stage loaded with the subject and the optical image forming system of the microscope; calculate a contrast value indicating a high and low contrast of a captured observation image; detect a maximum contrast image whose calculated contrast value is maximum in a plurality of performed observation images; detect the relative position of the stage and the optical image forming system; perform a correcting process of moving the detected relative position corresponding to the detected maximum contrast image by a specified value in a direction opposite the direction of the relative movement; and bring focus using the corrected relative position as a focal point. 1. A microscope system which brings an observation image into focus in a microscope , comprising:an image pickup unit which captures a subject at a specified time interval through an optical image forming system while relatively moving a stage loaded with the subject and the optical image forming system of the microscope;a contrast value calculation unit which calculates a contrast value indicating a high and low contrast of a captured observation image;a maximum contrast image detection unit which detects a maximum contrast image whose calculated contrast value is maximum in a plurality of performed observation images;a relative position detection unit which detects a relative position of the stage and the optical image forming system;a position correction unit which performs a correcting process of moving the detected relative position corresponding to the detected maximum contrast image by a specified value in a direction opposite the direction of the relative movement; andan autofocus unit which brings focus using the corrected relative position as a focal point.2. The system according to claim 1 , further comprisinga relative position detection unit which ...

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Номер записи: 80
11-07-2013 дата публикации

MICROSCOPE AND MICROSCOPE LIGHT SOURCE UNIT

Номер: US20130176618A1
Автор: HAYASHI Kazuhiro
Принадлежит: OLYMPUS CORPORATION

A microscope includes: a first epi-illumination light-source unit to perform fluorescence observation; a second transmitted-illumination light-source unit to perform transmission observation, the second transmitted-illumination light-source unit including a light source provided with a light emitting element that emits excitation light and a fluorescent substance that emits fluorescence upon irradiation with the excitation light; and an incidence limiting section configured to limit an incidence of light on the light source from an outside of the second light source unit during a light-off period of the light emitting element. The incidence limiting section is configured to remove an incidence limitation of the light from the outside while the light emitting element is being lit. 1. A microscope comprising:a first epi-illumination light-source unit configured to perform fluorescence observation;a second transmitted-illumination light-source unit configured to perform transmission observation, the second transmitted-illumination light-source unit including a light source provided with a light emitting element that emits excitation light and a fluorescent substance that emits fluorescence upon irradiation with the excitation light; andan incidence limiting section configured to limit incidence of light on the light source from an outside of the second light source unit during a light-off period of the light emitting element, whereinthe incidence limiting section is configured to remove an incidence limitation of the light from the outside while the light emitting element is being lit.2. The microscope according to claim 1 , whereinthe incidence limiting section is configured to start the incidence limitation of the light from the outside upon turning-off of the light emitting element.3. The microscope according to claim 2 , whereinthe second light source unit includes a switch to switch a state of the light emitting element between a light-on state and a light-off ...

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Номер записи: 81
18-07-2013 дата публикации

LASER SCANNING MICROSCOPE WITH SWITCHABLE OPERATING MODE

Номер: US20130182306A1
Автор: Anhut Tiemo, Kalkbrenner Thomas, Schwedt Daniel
Принадлежит: Carl-Zeiss Microscopy GmbH

A laser scanning microscope, which is switchable between different operating modes, wherein it contains, for switching in the illumination beam path, an electro-optical modulator (EOM) in a first beam path, which electro-optical modulator has arranged, upstream and downstream of it, adjustable first and second polarization-rotating elements and, downstream of it, at least one first polarization splitter for producing a second beam path, in which light-influencing means are located, wherein one or more of the following operating modes of the LSM can be set:—Single spot LSM—multispot LSM—single spot FMM—multispot FMM—FRAP system. 1. A laser scanning microscope which can be switched between different operating modes , comprising an electro-optic modulator (EOM) in a first beam path in an illumination beam path , for the purpose of switching , and adjustable , first and second polarization rotating elements disposed before and after said electro-optic modulator EOM , and at least one first polarization splitter is disposed after the same for the purpose of generating a second beam path , wherein light-influencing means are disposed in the same.2. A laser scanning microscope according to claim 1 , wherein the first element is set for the EOM operating mode claim 1 , and the second element undertakes the configuration for the first or second beam path.3. A laser scanning microscope according to claim 1 , wherein a unification of the first and second beam paths is realized via a second polarization splitter behind the light-influencing means in the direction of light travel claim 1 , and the EOM can be switched between at least two operating modes (i) switching of the polarization; and (ii) different modulation for different regions of the EOM claim 1 , to generate a focus modulation (FMM).4. A laser scanning microscope according to claim 1 , wherein the polarization rotating elements are lambda half plates.5. A laser scanning microscope according to claim 1 , wherein the ...

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Номер записи: 82
25-07-2013 дата публикации

IR microscope with image field curvature compensation, in particular with additional illumination optimization

Номер: US20130188034A1
Автор: Juette Michael, KEENS Axel
Принадлежит: BRUKER OPTIK GMBH

An IR microscope () is constituted such that, in an optical viewing mode in a beam path of visible light (VIS-R, VIS-T), a first intermediate focus (ZW) is imaged onto a flat detector surface () of a camera. The IR microscope () is constituted such that, in the beam path of the visible light (VIS-R, VIS-T), the first intermediate focus (ZW) is imaged onto a second intermediate focus (ZW), and, in the second intermediate focus (ZW), a Mangin mirror () is disposed that corrects a field curvature of the Cassegrain objective (). The invention provides an IR microscope in which the field curvature generated by the Cassegrain objective is corrected in a simple manner in the optical viewing mode when detection is performed using a flat detector and without restricting the spectral range of the IR microscope. 1. An infrared (=IR) microscope , the microscope comprising;elements defining a beam path for visible light;elements defining a beam path for IR light;a first intermediate focus;a Cassegrain objective having a sample position, said Cassegrain objective imaging the sample position onto said first intermediate focus, wherein said beam paths for visible and for IR light are coextensive in a region of the sample position;an IR detector, wherein the IR microscope is constituted such that, at least in an IR viewing mode, IR light is directed from said first intermediate focus to said IR detector;a second intermediate focus, wherein the IR microscope is constituted such that, in the beam path for visible light, said first intermediate focus is imaged onto said second intermediate focus;a Mangin mirror disposed at said second intermediate focus, said Mangin mirror being structured to correct a field curvature of said Cassegrain objective; anda flat viewing surface disposed downstream of said Mangin mirror, wherein, at least in an optical viewing mode and in the beam path for visible light, said first intermediate focus is imaged onto said flat viewing surface.2. The IR ...

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Номер записи: 83
25-07-2013 дата публикации

MICROSCOPE SYSTEM

Номер: US20130188250A1
Автор: YOKOI Eiji
Принадлежит: OLYMPUS CORPORATION

A microscope system that performs structured illumination includes a light source configured to emit illumination light, an objective lens that irradiates a specimen with the illumination light, a phase-modulation spatial light modulator that has a two-dimensional pixel structure, that is arranged at the pupil conjugate position of the objective lens on an illumination light path between the light source and the objective lens, and that is configured to modulate a phase of the illumination light for each pixel so as to form a fringe illumination pattern on the specimen on the basis of an optical parameter of at least one of the light source and the objective lens. 1. A microscope system that performs structured illumination , comprising:a light source configured to emit illumination light;an objective lens that irradiates a specimen with the illumination light;a phase-modulation spatial light modulator that has a two-dimensional pixel structure, that is arranged at a pupil conjugate position of the objective lens on an illumination light path between the light source and the objective lens, and that is configured to modulate a phase of the illumination light for each pixel so as to form a fringe illumination pattern on the specimen on the basis of an optical parameter of at least one of the light source and the objective lens.2. The microscope system according to claim 1 , further comprising:an operation unit configured to calculate a phase modulation pattern having the pixel structure for forming a fringe illumination pattern on the specimen on the basis of the optical parameter of at least one of the light source and the objective lens.3. The microscope system according to claim 2 , wherein:the optical parameter includes at least one of a wavelength of the illumination light emitted from the light source, a numerical aperture of the objective lens, and a magnification of the objective lens.4. The microscope system according to claim 2 , wherein:the operation unit ...

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Номер записи: 84
25-07-2013 дата публикации

Microscope and inspection apparatus

Номер: US20130188251A1
Автор: Haruhiko Kusunose, Takao Tsubouchi
Принадлежит: Lasertec Corp

A system including a microscope and an inspection apparatus in which an objective lens having a large numerical aperture is used for detecting a defect existing inside a sample. A light source apparatus produces linearly polarized light. The polarization maintaining fibers optically coupled to the light source apparatus project the linearly polarized light onto the sample surface as an illumination beam of P-polarized light at an incidence angle substantially equal to the Brewster's angle of the sample. The scattered light generated by the defect existing in the sample is emitted from the sample and is collected by the objective lens whose optical axis is perpendicular to the sample surface. Since the illumination beam of P-polarized light is projected at the incidence angle equal to the Brewster's angle of the sample, no surface reflection occurs and it is possible to use the objective lens having a large numerical aperture.

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Номер записи: 85
25-07-2013 дата публикации

Coupling-in apparatus for coupling light from a light-emitting diode into a fiber entry end and light-source arrangement fitted therewith

Номер: US20130188385A1
Автор: Markus Bausewein, Peter Reimer
Принадлежит: CARL ZEISS MEDITEC AG

A coupling-in apparatus is provided for coupling light from a light-emitting diode ( 1 ) into a fiber entry end ( 5 ) of at least one optical fiber ( 3 ). The coupling-in apparatus has a changing device ( 7 ) and a first light-guide element ( 13 - 19 ) arranged on the changing device ( 7 ). The first light-guide element ( 13 - 19 ) has specific transmission properties, an entry end ( 27 ) and an exit end ( 29 ). The changing device ( 7, 107 ) can be arranged and moved into a position with respect to the light-emitting diode ( 1 ) and the fiber entry end ( 5 ) such that the entry end ( 27 ) of the light-guide element ( 13 - 19 ) lies opposite the light-emitting diode ( 1 ) and the exit end ( 29 ) of the light-guide element ( 13 - 19 ) lies opposite the fiber entry end ( 5 ).

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Номер записи: 86
01-08-2013 дата публикации

Portable retinal imaging device

Номер: US20130194548A1
Автор: Lan Sun, Robert Paul FRANCIS
Принадлежит: Raytheon Co

A portable MEMS-based scanning laser ophthalmoscope (MSLO). In one example the MSLO includes a laser illumination sub-assembly that generates a laser illumination beam, a two-dimensional MEMS scan mirror configured to receive and scan the laser illumination beam over at least a portion of the retina of an eye to be imaged, an optical system configured to direct the laser illumination beam from the scan mirror into the eye to illuminate the retina, and a detector sub-assembly configured to intercept optical radiation reflected from the eye to generate an image of the retina. The optical system includes a polarized beamsplitter positioned between the scan minor and the eye and configured to direct the laser illumination beam to into the eye and to direct the optical radiation reflected from the eye to the detector sub-assembly.

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Номер записи: 87
01-08-2013 дата публикации

Microscope Objective Lens

Номер: US20130194660A1
Автор: Goto Hisashi, Kajitani Kazuo, Ode Hisashi, Suzuki Yoshimasa
Принадлежит: OLYMPUS CORPORATION

A microscope objective lens has an aspheric-surface lens, and a first lens nearest to an object side is a negative lens. It is desirable that at least any one surface of the first lens nearest to the object side is an aspheric surface. Moreover, it is desirable that the microscope objective lens satisfies the following conditional expression (1) 1. A microscope objective lens comprising:an aspheric-surface lens, whereina first lens nearest to an object side is a negative lens.2. The microscope objective lens according to claim 1 , wherein at least any one surface of the first lens nearest to the object side is an aspheric surface.3. The microscope objective lens according to claim 1 , wherein the microscope objective lens satisfies the following conditional expression (1){'br': None, 'i': Подробнее

Номер записи: 88
01-08-2013 дата публикации

Microscope Objective Lens

Номер: US20130194678A1
Автор: Hisashi Goto, Hisashi Ode, Kazuo Kajitani, Yoshimasa Suzuki
Принадлежит: Olympus Corp

A microscope objective lens satisfies the following conditional expressions (1) and (2). 0.05<NA<0.4  (1) 3 mm< D /NA<50 mm  (2) where, NA denotes a numerical aperture on an object side of the microscope objective lens, and D denotes a total thickness of the microscope objective lens.

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Номер записи: 89
08-08-2013 дата публикации

FLUORESCENT MICROSCOPE FOR OBSERVING MULTIPLE FLUORESCENT IMAGES, FLUORESCENT IMAGE SURVEYING METHOD USING THE SAME, AND MULTIPLE FLUORESCENT IMAGE OBSERVING SYSTEM

Номер: US20130201322A1
Автор: Chung Chan Il, Hwang Jeoung Ku, Kim Jee Young, Park Hwa Joon
Принадлежит: NANOENTEK, INC.

A fluorescent microscope for observing multiple fluorescent images includes: a first optical module comprising a first light source for supplying first excitation light having a first wavelength, a first excitation filter for selectively transmitting the first excitation light supplied from the first light source, a first dichroic filter for reflecting the first excitation light having passed through the first excitation filter toward the survey object, an objective lens for condensing the first excitation light reflected by the first dichroic filter and transferring the condensed first excitation light to the survey object, a second dichroic filter for reflecting first radiation light radiated from the survey object, a first radiation filter for selectively transmitting the first radiation light reflected by the second dichroic filter, and a first image acquisition unit for acquiring an image by using the first radiation light having passed through the first radiation filter to be supplied; and a second optical module comprising a second light source for supplying second excitation light having a second wavelength, a second excitation filter for selectively transmitting the second excitation light supplied from the second light source, a second radiation filter passing through the second excitation filter and irradiated to the survey object to be radiated, to selectively transmitting the second radiation light EM having passed through the objective lens, the first dichroic filter, and the second excitation filter, and a second image acquisition unit for acquiring an image by using the second radiation light having passed through the second radiation filter to be supplied. 1. A fluorescent microscope for observing multiple fluorescent images , the fluorescent microscope comprising:a first optical module comprising a first light source for supplying first excitation light having a first wavelength, a first excitation filter for selectively transmitting the first ...

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Номер записи: 90
08-08-2013 дата публикации

SPECIAL-ILLUMINATION SURGICAL STEREOMICROSCOPE

Номер: US20130201552A1
Автор: SANDER ULRICH
Принадлежит: Leica Microsystems (Schweiz) AG

The present invention relates to a special-illumination surgical stereomicroscope () for observing an object () in an object field () under special illumination, the special-illumination surgical stereomicroscope including a surgical illumination light source () for illuminating the object field () via an illumination beam path () and further including a special-illumination light source. The special-illumination light source is adapted for observation of stimulated emission and includes an excitation light source () for specific excitation of a substance contained in the tissue of the object () via an excitation beam path (), and a stimulation light source () for stimulating the emission of light from the previously excited substance via a stimulation beam path (). A common observation beam path () is provided for guiding the light generated by stimulated emission and the reflected surgical illumination light. 11615. A special-illumination surgical stereomicroscope () for observing an object () in an object field () under special illumination , comprising:{'b': 7', '7', '15', '11, 'i': 'a', 'claim-text': [{'b': 8', '6', '12, 'i': a', 'a, 'an excitation light source () for specific excitation of a substance contained in tissue of the object () via an excitation beam path (),'}, {'b': 8', '12, 'i': b', 'b, 'a stimulation light source () for stimulating the emission of light from the previously excited substance via a stimulation beam path (), and'}, {'b': 14', '6, 'a common observation beam path () for guiding the light generated by stimulated emission and surgical illumination light reflected by the object ().'}], 'a surgical illumination light source (; ) for illuminating the object field () via an illumination beam path (), the surgical illumination light source comprising a special-illumination light source, wherein the special-illumination light source is adapted for observation of stimulated emission and includes2888812121215abab. The special-illumination ...

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Номер записи: 91
22-08-2013 дата публикации

FOCUSING APPARATUS AND METHOD

Номер: US20130215502A1
Автор: Booth Martin James, Botcherby Edward, Juskaitis Rimvydas, Wilson Tony
Принадлежит: ISIS INNOVATION LIMITED

A focusing apparatus for use with an optical system having a high NA objective lens includes an image forming and capturing mechanism for forming an image in an intermediate image zone and for capturing an image by receiving and refocusing light from a selected focal plane within the intermediate image zone, and a focus adjusting mechanism for adjusting the position of the selected focal plane within the intermediate image zone. The image forming and capturing mechanism includes at least one high NA lens. In use, spherical aberration introduced by the high NA objective lens is reduced. 1an image forming and capturing means configured to receive light from a specimen via the high NA objective lens, wherein the image forming and capturing means includes a high NA lens that focuses the light received via the high NA objective lens to form an image in an intermediate image zone, and a reflective element that reflects the image formed by the high NA lens back into the same high NA lens to capture an image from a selected focal plane within said intermediate image zone; anda focus adjusting means that adjusts an axial position of the reflective element to adjust a position of the selected focal plane within the intermediate image zone, whereby spherical aberration is reduced.. A focusing apparatus for use with an optical system having a high numerical aperture (NA) objective lens, the apparatus including: This application is a continuation of U.S. patent application Ser. No. 13/296,975, filed Nov. 15, 2011, which is a division of U.S. patent application Ser. No. 12/519,517, filed Aug. 17, 2009, now U.S. Pat. No. 8,144,395, which is a U.S. National Phase filing under 35 U.S.C. §371 of PCT/GB2007/004916, filed Dec. 20, 2007, which claims priority to Great Britain Patent Application No. 0625775.2, filed Dec. 22, 2006. The disclosures of all these prior applications are incorporated herein by reference in their entireties for all purposes.1. Field of the InventionThe present ...

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Номер записи: 92
22-08-2013 дата публикации

Scratch detection method and apparatus

Номер: US20130216122A1
Автор: Mitch Grant, Wei Zhou
Принадлежит: Rudolph Technologies Inc

A method of identifying discontinuities in the surface of a substrate is herein disclosed. An object plane of an imaging system is positioned at a focal position associated with a discontinuity and an image is captured, the discontinuity having a relatively higher contrast with respect to the remainder of the surface of the substrate. The discontinuity is thereby more readily discernable than when the focal plane is positioned at the surface of the substrate. Analysis of discontinuities may include the extraction of discontinuity characteristics.

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Номер записи: 93
29-08-2013 дата публикации

Automated slide scanning system for a microscope

Номер: US20130222895A1
Автор: William Gelbart
Принадлежит: William Gelbart

An automated slide scanning system is described. The system comprises an automated focusing unit that is simple and that provides a fine adjustment of a focusing tube without any backlash. The focusing unit comprises a block that is cut or fabricated in a pattern forming a head to support a focusing tube and at least one elongated and rigid arm projecting perpendicularly from the head. One end of the at least one arm is integrally joined to the head. The focusing unit further comprises an elongated, rigid, lever which is substantially parallel and spaced apart from the at least one arm. The lever is pivotally mounted to a hinge and has a first end that is linked to the head of the focusing unit and a second free end. The focusing unit further includes a drive mechanism with a roller coupled to a motor. The roller is eccentric roller and is in constant contact to the lever's second end. When the roller rotates it engages the lever which subsequently engages the at least one arm and thus produces a substantially vertical movement in both direction to the head of the focusing unit. The scanning system further comprises a scanning stage that supports the focusing unit and which provides a continuous movement in Y-direction (back and forward) of the scanning stage, and a scanning track that moves the slide holder continuously in one direction along the x-axis until the last slide in the slide holder is scanned. The scanning system of the present invention is suitable for automated screening or prescreening of samples.

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Номер записи: 94
29-08-2013 дата публикации

OBJECTIVE CHANGER

Номер: US20130222898A1
Автор: Gilbert Manfred, Pfeifer Gerhard
Принадлежит:

A microscope objective changer includes a changing device for changing at least two objectives. A movable objective holder corresponds to each objective. Each movable objective holder is configured to receive a respective one of the objectives and to transfer the respective objective along a respective displacement path from an allocated stand-by position into an operating position. A carrier is associated with each objective holder and includes a guide groove constituting the respective displacement path. Each displacement path includes a first portion beginning at the respective stand-by position and extends substantially perpendicular to the optical axis and a second portion directly bordering the first portion that includes a downwardly component in a direction parallel to the optical axis such that each objective holder is movable from the respective stand-by position to the optical axis of the operating position when reaching a lower end of the second portion of the displacement path. 125-. (canceled)26. A microscope objective changer comprising:a changing device for changing at least two objectives;a movable objective holder corresponding to each objective, each movable objective holder being configured to receive a respective one of the objectives and to transfer the respective objective along a respective displacement path from an allocated stand-by position into an operating position, the operating position defining an optical axis, the respective displacement paths being different from one another; anda carrier associated with each objective holder and including a guide groove constituting the respective displacement path, each displacement path including a first portion beginning at the respective stand-by position and extending substantially perpendicular to the optical axis and a second portion directly bordering the first portion and including a downwardly component in a direction parallel to the optical axis such that each objective holder is movable ...

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Номер записи: 95
29-08-2013 дата публикации

MICROSCOPE OBJECTIVE LENS

Номер: US20130222920A1
Автор: FUJITA Yuso
Принадлежит: OLYMPUS CORPORATION

A microscope objective lens includes, in an order starting from an object side, a first lens group having a positive power, a second lens group having a positive power, a third lens group having a negative power, and a fourth lens group having a positive power. The second lens group is configured to move in an optical axis direction between the first lens group and the third lens group so as to correct a variation in an aberration caused by a thickness of a cover glass. The following conditions are satisfied: 1. A microscope objective lens , comprising in order starting from an object side:a first lens group having positive power;a second lens group having positive power;a third lens group having negative power; anda fourth lens group having positive power, wherein:the second lens group is configured to move in an optical axis direction between the first lens group and the third lens group so as to correct a variation in an aberration caused by a thickness of a cover glass; and [{'br': None, '0.65 Подробнее

Номер записи: 96
05-09-2013 дата публикации

Three-dimensional confocal microscopy apparatus and focal plane scanning and aberration correction unit

Номер: US20130229493A1
Автор: Koji Ikuta, Masashi Ikeuchi
Принадлежит: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Provided is a 3-dimensional confocal microscopy apparatus which is manufactured by combining a confocal microscope and an optical tweezers technique, wherein a pair of lenses for focal plane displacement where one lens is movable in the optical axis direction is arranged between a fixed objective lens and a fluorescent light imaging camera, and the 3-dimensional confocal microscopy apparatus also includes a mean which corrects the aberration of a fluorescent confocal image obtained by the fluorescent imaging camera. Accordingly, it is possible to provide a 3-dimensional confocal microscopy apparatus which can acquire a 3-dimensional image of a specimen during a manipulation of the specimen using optical tweezers without affecting an optical trap.

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Номер записи: 97
05-09-2013 дата публикации

STRUCTURED ILLUMINATION APPARATUS, STRUCTURED ILLUMINATION MICROSCOPY APPARATUS, AND PROFILE MEASURING APPARATUS

Номер: US20130229665A1
Автор: NOMURA Tatsushi
Принадлежит: NIKON CORPORATION

A structured illumination apparatus includes a light modulator being disposed in an exit flux of light from a light source and in which a sonic wave propagation path is arranged in a direction traversing the exit flux of light; a driving unit generating a sonic standing wave in the sonic wave propagation path by giving a driving signal for vibrating a medium of the sonic wave propagation path to the light modulator; and an illuminating optical system making mutually different diffracted components of the exit flux of light passed through the sonic wave propagation path to be interfered with each other, and forming interference fringes of the diffracted components on an observational object. 1. A structured illumination apparatus , comprising:a light modulator being disposed in an exit flux of light from a light source, and in which a sonic wave propagation path is arranged in a direction traversing the exit flux of light;a driving unit generating a sonic standing wave in the sonic wave propagation path by giving a driving signal for vibrating a medium of the sonic wave propagation path to the light modulator; andan illuminating optical system making mutually different diffracted components of the exit flux of light passed through the sonic wave propagation path to be interfered with each other, and forming interference fringes of the diffracted components on an observational object.2. The structured illumination apparatus according to claim 1 , whereinthe driving unit generates the sonic standing wave by setting a frequency of the driving signal given to the light modulator to a predetermined frequency.3. The structured illumination apparatus according to claim 2 , further comprisingan adjusting unit adjusting at least one of the frequency and an amplitude of the driving signal in accordance with a temperature of the medium of the sonic wave propagation path.4. The structured illumination apparatus according to claim 3 , further comprisinga temperature sensor ...

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Номер записи: 98
05-09-2013 дата публикации

BEAM SPLITTER AND OBSERVATION APPARATUS

Номер: US20130229707A1
Автор: SAKAGUCHI Akira
Принадлежит: SANYO ELECTRIC CO., LTD

An observation apparatus comprising: a beam-splitter including first and second plane-parallel plates respectively having first and second faces and third and fourth faces parallel to one another, and a light-splitting section allowing T % of incident light from a first-and-third-face side to pass therethrough to a second-and-fourth-face side, as transmitted light, while reflecting (100−T) % thereof in a direction parallel with the first to fourth faces as reflected light; and first and second observation optical systems to observe an entire observation target and partially magnify and observe the target, respectively, the first and second plane-parallel plates including light-reducing sections, allowing T % of the incident light to pass therethrough, in areas through which neither the incident nor transmitted light pass, the beam splitter arranged so that the first and third faces oppose the target and the transmitted and reflected lights are guided to the first and second observation optical systems, respectively. 1. An observation apparatus comprising: a first plane parallel plate, having first and second faces parallel to each other, with a refractive index higher than a refractive index of air,', 'a second plane parallel plate, having third and fourth faces arranged to be on the same level as the first and the second faces, respectively, with a refractive index equal to a refractive index of the first plane parallel plate, and', 'a light splitting section arranged between the first and the second plane parallel plates, the light splitting section configured to allow T % (0 Подробнее

Номер записи: 99
05-09-2013 дата публикации

FILTER WHEEL

Номер: US20130229708A1
Автор: TAFAS Triantafyllos, THOMAS Michael
Принадлежит: Ikonisys, Inc.

An improved filter wheel is disclosed, through embodiments, that comprises a plurality of reflector support structures formed as a unitized structure with a circular base member. In some embodiments, the filter wheel further comprises a plurality of light sources mounted on the filter wheel. 110-. (canceled)11. A filter wheel apparatus comprising:a hollow right circular cylinder, comprising a cylindrical wall attached at its top edge to a planar circular solid base member perpendicular to an axis of rotation is and centered on the circular solid base member;{'b': '12', 'a mechanical shaft coupler positioned where the axis of rotation penetrates the circular solid base member; the mechanical shaft coupler being configured to fixedly fasten the filter wheel to a shaft that may be rotated by an actuator or motor; the filter wheel having a rotational position telemetered by sensors located on, or in proximity to, the filter wheel.'}12. The filter wheel apparatus of claim 11 , wherein the sensors are mounted directly to the shaft.13. The filter wheel apparatus of claim 11 , wherein the circular solid base member is penetrated by a plurality of base apertures whose centers are spaced about the circumference of a circle having a radius less than that of the circular solid base member.14508050. The filter wheel apparatus of claim 11 , wherein a first filter retaining structure may be associated with each of the base apertures and configured to secure an optical filter across the respective base member aperture .15. The filter wheel apparatus of claim 11 , wherein said optical filter may be a band pass filter that transmits light falling within a band of emission wavelengths while attenuating light having other wavelengths.16. A filter wheel apparatus of an automated microscope claim 11 , comprising a plurality of optical component modules positioned at angular intervals around the filter wheel claim 11 , wherein each of the plurality of optical modules comprise the filters ...

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Номер записи: 100