ВЕРОЯТНОСТЬ ПОВРЕЖДЕНИЯ ЗДОРОВЫХ ТКАНЕЙ, АДАПТИРОВАННАЯ С УЧЕТОМ МАРКЕРОВ

Группа изобретений относится к медицине, онкологии и касается формирования плана индивидуальной терапии пациента. Способ включает формирование исходного плана терапии с помощью вероятностной модели осложнения здоровой ткани (NTCP) и вероятностной модели подавления опухоли (TCP) целевой области. Модели NTCP и TCP адаптируют на основании начальных количественных значений набора биомаркеров пациента. После применения исходной терапии формируют исправленный план терапии с помощью моделей NTCP и TCP, адаптированных на основании обновленных после применения терапии количественных значений набора биомаркеров. Начальные и обновленные модели NTCP выражены в виде функции эквивалентной однородной дозы (EUD), модифицированной с использованием скалярной величины. Значения наборов биомаркеров представляют собой определяемые путем исследования значения параметров из группы: уровни Hb, CRP, PSA, TNF-α, ферритина, трансферрина, LDH, IL-6, гепсидина, креатинина, глюкозы, HbA1c, комплексов, связывающихся ...

СПОСОБ ГЕНЕРИРОВАНИЯ ОПИСАТЕЛЬНЫХ ОТЧЕТОВ ИЗ ИСПОЛНИМЫХ КЛИНИЧЕСКИХ ПРОТОКОЛОВ

Изобретение относится к области информационных технологий, а именно к формированию электронных медицинских карт. Технический результат заключается в расширении арсенала средств того же назначения. Устройство для формирования медицинских записей и отчетов, включающее носитель для хранения, хранящий модель клинического протокола, содержащую шаблоны описательных клинических аннотаций, связанные с переходами между узлами в модели процесса клинического протокола, и инструмент управления процессом, выполненный с возможностью исполнения на вычислительном устройстве и имеющий: обработчик рабочего потока для исполнения пути пациента по модели процесса клинического протокола посредством прохождения узлов модели процесса клинического протокола в соответствии со специфической для пациента информацией, хранящейся в электронной медицинской карте (ЭМК), и генератор содержания для генерирования содержания описательного отчета по клиническому протоколу для пациента посредством заполнения полей шаблонов ...

УСТРОЙСТВА МЕМБРАННОГО РАЗДЕЛЕНИЯ, СИСТЕМЫ И СПОСОБЫ, ПРИМЕНЯЮЩИЕ УКАЗАННЫЕ УСТРОЙСТВА

Изобретение относится к устройствам мембранного разделения. Способы заполнения мембранного сепаратора с вращающейся мембраной, в котором сепаратор содержит корпус с верхом и низом, мембрана сконфигурирована для вращения вокруг вертикально ориентированной оси, при этом между корпусом и мембраной образован зазор, при этом мембрана содержит поверхность, через которую происходит разделение, ориентированную вертикально, при этом способ содержит введение раствора для заполнения через канал внизу корпуса; протекание дополнительного раствора для заполнения через канал внизу корпуса, с тем чтобы сформировалась поверхность раздела раствор для заполнения - воздух в зазоре между корпусом и мембраной, которая продвигается вверх через корпус и вверх через поверхность мембраны для вытеснения воздуха внутри корпуса и выталкивания воздуха через канал наверху корпуса c одновременным смачиванием мембраны; и продолжение протекания дополнительного раствора для заполнения через канал внизу корпуса в зазор. Также ...

Способ применения информации о сложной группе биомаркеров для диагностики злокачественной опухоли легкого у субъекта, диагностический набор и вычислительная система с её использованием

Группа изобретений относится к медицине, а именно к онкологии, и может быть использована для диагностирования злокачественной опухоли легкого у субъекта. Способ предусматривает следующие стадии: 1) применяют вычислительную систему для получения модели диагностирования злокачественной опухоли легкого. Модель устанавливают с использованием: данных уровня экспрессии отдельных биомаркеров в сложной группе биомаркеров, измеренных из биологических образцов выборки, состоящей из пациентов со злокачественной опухолью легкого и людей без злокачественной опухоли легкого, или их обработанных данных B, где k представляет собой индекс для отдельных биомаркеров и i представляет собой индекс для отдельных биологических образцов выборки; 2) применяют вычислительную систему для получения данных уровня экспрессии отдельных биомаркеров, измеренных в биологическом образце субъекта, или их обработанных данных B, или данных уровня экспрессии отдельных биомаркеров, или их обработанных данных Bи возраст субъекта ...

СИСТЕМА ДЛЯ АВТОМАТИЗИРОВАННОГО АНАЛИЗА РЕЗУЛЬТАТОВ ЛАБОРАТОРНЫХ ИССЛЕДОВАНИЙ И ОПОВЕЩЕНИЯ О РИСКЕ В ОТДЕЛЕНИИ ИНТЕНСИВНОЙ ТЕРАПИИ

Изобретение относится к медицине. Технический результат заключается в расширении арсенала средств. В системе для оценки уровня риска множества клинических состояний сохраняют группу результатов лабораторных исследований с временными метками для пациента. Для каждого клинического состояния определяют уровень риска клинического состояния на основании специфической для клинического состояния подгруппы из сохраненной группы результатов лабораторных исследований, при условии, что сохраненная специфическая для клинического состояния подгруппа результатов лабораторных исследований достаточна для определения уровня риска. Каждому определенному уровню риска присваивают временную метку на основании временных меток для результатов лабораторных исследований. На устройстве отображения отображают определенный уровень риска и присвоенную временную метку для каждого клинического состояния, определенный уровень риска которого соответствует критерию отображения. 4 н. и 16 з.п. ф-лы, 5 ил.

СИСТЕМА КОНТРОЛЯ КАЧЕСТВА, СПОСОБ И МАШИНОЧИТАЕМЫЙ НОСИТЕЛЬ ДЛЯ ИСПОЛЬЗОВАНИЯ С ДИАГНОСТИЧЕСКИМИ ПРИБОРАМИ ДЛЯ БИОЛОГИЧЕСКИХ/ЭКОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙ ИХ ПОЛЬЗОВАТЕЛЯМИ И РАСХОДНЫМИ МАТЕРИАЛАМИ

... 1. Система контроля качества (КК) для использования с одним или несколькими диагностическими приборами для биологических или экологических исследований и одним или несколькими их пользователями и расходными материалами, в которую входят:(а) подсистема данных КК, обеспечивающая: (i) сбор поступающих от диагностических приборов тестовых данных КК, относящихся к диагностическим приборам, пользователям и расходным материалам, при этом подсистема данных КК обеспечивает сбор тестовых данных КК, поступающих по меньшей мере от одного из местных диагностических приборов и относящихся к нему; и (ii) определение для каждых одних соответствующих тестовых данных КК одного или нескольких соответствующих параметров КК на основании диагностических приборов, пользователей и расходных материалов, так что подсистема данных КК определяет один или несколько соответствующих параметров КК для диагностических приборов, пользователей и расходных материалов,(б) подсистема анализа КК, обеспечивающая выполнение одного ...

АППАРАТ И СПОСОБ СОЕДИНЕНИЯ ОБОРУДОВАНИЯ ДЛЯ СТЕРИЛИЗАЦИИ МЕДИЦИНСКИХ УСТРОЙСТВ

ВЫБОР ДЫХАТЕЛЬНОГО ЦИКЛА ДЛЯ АНАЛИЗА

СПОСОБ ЛЕЧЕНИЯ РОГОВИЦЫ И УСТРОЙСТВО ДЛЯ ЕГО ОСУЩЕСТВЛЕНИЯ

... 1.Устройство для лечения роговицы, содержащее запоминающее устройство (4), интерфейс (8), позволяющее получать и предоставлять данные, а также блок (6) обработки данных для вычисления и предоставления на интерфейс (8) офтальмологической величины, используемой при лечении роговицы,отличающееся тем, что также содержит блок (10) управления, предусмотренный для получения данных о начальном показателе (KC) центральной кератометрии и данных о значении начальной асферичности (QI) после их получения на интерфейс (8), сохранения этих данных в запоминающем устройстве (4), вызова блока (6) обработки данных о начальном показателе (KC) центральной кератометрии и значении начальной асферичности (QI), а также данных о значении целевой асферичности (QV) для вычисления показателя периферической кератометрии (KP), сохранения соответствующих данных в запоминающем устройстве (4) и предоставления их на интерфейс (8).2. Устройство по п. 1, отличающееся тем, что блок (6) обработки данных предусмотрен для вычисления ...

УСТРОЙСТВА МЕМБРАННОГО РАЗДЕЛЕНИЯ, СИСТЕМЫ И СПОСОБЫ, ПРИМЕНЯЮЩИЕ УКАЗАННЫЕ УСТРОЙСТВА, И СИСТЕМЫ И СПОСОБЫ УПРАВЛЕНИЯ ДАННЫМИ

... 1. Устройство фильтрации крови, содержащее:по существу, цилиндрический корпус, имеющий внутреннюю стенку;внутренний элемент, установленный внутри корпуса и имеющий внешнюю поверхность;внутреннюю стенку корпуса и/или внешнюю поверхность внутреннего элемента, содержащую пористую мембрану, расположенную на расстоянии от передней стенки корпуса или поверхности внутреннего элемента, с образованием кольцевого зазора между ними;при этом корпус и внутренний элемент могут вращаться относительно друг друга;впуск для направления цельной крови, содержащей плазму и эритроциты, в кольцевой зазор;первый выпуск для направления плазмы, проходящей через мембрану, в контейнер для сбора; ивторой выпуск для направления из кольцевого зазора оставшихся компонентов крови;при этом мембрана имеет площадь поверхности, достаточную для отделения плазмы с такой скоростью потока, что время нахождения эритроцитов в пределах кольцевого зазора является недостаточным для того, чтобы вызвать ненадлежащий гемолиз эритроцитов ...

УСТРОЙСТВО ДЛЯ ПРОСЛЕЖИВАЕМОЙ МАРКИРОВКИ КОНТЕЙНЕРОВ С БИОЛОГИЧЕСКИМИ МАТЕРИАЛАМИ

... 1. Устройство для идентификации пациента и маркировки пробирок (13), ассоциированных с упомянутым пациентом, перед сбором биологических материалов, подвергаемых анализу, содержащее:высокобезопасное портативное аппаратное устройство (1) для обработки и хранения данных пациента, способное ассоциировать персональные данные пациента с биометрическими данными,устройство (2) считывания и распознавания биометрических данных пациента упомянутого портативного аппаратного устройства,персональный компьютер (4), взаимодействующий с оператором и соединенный с локальной сетью (50) передачи данных для обмена информацией с удаленным средством хранения данных,одну или более компьютеризованных этикетировочных машин (5) для пробирок (13), каждая из которых содержит принтер (11) для печати штрих-кодов на этикетках (10), выполненный с возможностью получения команд печати после сравнения прогнозируемых и обнаруженных проб, расположенных в устройстве (12) позиционирования и распознавания, поддерживаемом упомянутой ...

Vorgeburtliche Überprüfung von Schwangerschaftsabnormitäten

Testkassette

Testkassette (1) zur Durchführung eines Lateral-Flow-Tests zum qualitativen Nachweis von Stoffen mit Antikörpern umfassend- einen in der Testkassette (1) angeordneten Testreifen (2),- einen auf dem Teststreifen (2) angeordneten Probenbereich (3) auf den eine zu testende Probe aufgegeben wird,- einen auf dem Teststreifen (2) angeordneten Testbereich (5), der zur Anzeige des Testergebnisses eingerichtet ist,- eine Öffnung (4) in der Testkassette (1), die oberhalb des Probenbereichs (3) des Teststreifens angeordnet ist, gekennzeichnet durch- eine elektronische Schaltung (9) umfassend einen innerhalb der Testkassette angeordneten Zeitgeber (10) und mindestens eine an der Testkassette (1) angeordnete Anzeige (11),- eine Spannungsversorgung (13) für die elektronische Schaltung (9) umfassend eine innerhalb der Testkassette angeordnete Batterie (7) und einen Federkontakt (15), der zur Herstellung einer elektrisch leitenden Verbindung zwischen einem der beiden Pole (17) der Batterie (7) und der ...

System zum patientenspezifischen Modellieren von Blutfluss

System zum Bestimmen von kardiovaskulären Informationen für einen Patienten, wobei das System Folgendes umfasst: wenigstens ein Computersystem, das konfiguriert ist, um: patientenspezifische Daten bezüglich einer Geometrie einer anatomischen Struktur des Patienten zu empfangen, wobei die anatomische Struktur wenigstens einen Abschnitt einer Mehrzahl an Koronararterien, die von einer Aorta ausgehen, beinhaltet; basierend auf den patientenspezifischen Daten ein dreidimensionales Modell zu erzeugen, das einen ersten Abschnitt der anatomischen Struktur repräsentiert, wobei der erste Abschnitt der anatomischen Struktur wenigstens den Abschnitt der Mehrzahl an Koronararterien beinhaltet; wenigstens teilweise basierend auf einer Masse oder einem Volumen des Myokardgewebes ein physikbasiertes Modell bezüglich einer Blutflusseigenschaft im ersten Abschnitt der anatomischen Struktur zu erzeugen; und wenigstens teilweise basierend auf dem dreidimensionalen Modell und dem physikbasierten Modell eine ...

Analyse- und Interpretationssystem für Diabetes-Daten

Verfahren zur Planung einer Untersuchung

Es wird ein Verfahren zur Planung einer Untersuchung eines Untersuchungsobjekts (O) mittels eines Tomosynthesegeräts (2) beschrieben, das folgende Schritte aufweist. In einem ersten Schritt werden Rohdaten (RD) des Untersuchungsobjekts (O) erfasst, welche aus definierten Akquisitionswinkeln akquiriert wurden. In einem zweiten Schritt wird ein Hilfsdatensatz aus den Rohdaten (RD) rekonstruiert. Folgend werden in einem dritten Schritt Tiefendaten auf Basis des Hilfsdatensatzes berechnet Berechnung eine Anzahl von Projektionen (P) aus Sicht eines jeweils definierten Projektionszentrums auf Basis des Hilfsdatensatzes oder auf Basis der Rohdaten (RD) berechnet. Dabei umfassen die Projektionen (P) jeweils eine Anzahl von Bildpunkten und jeder Bildpunkt ist mit den ihm zugeordneten Tiefendaten verknüpft. In Schritt vier werden die Projektionen (P) angezeigt, in Schritt fünf zumindest eine Projektion (P) ausgewählt. Darin wird in einem sechsten Schritt eine Position (M) eines Untersuchungsbereichs ...

Testkit für einen Covid-Test

Testkit (1) für einen Covid Test (6), aufweisend eine Verpackung (2), in welcher ein Covid Selbsttest (4) vorhanden ist, welcher mindestens einen Teststreifen (10) aufweist, wobei der Teststreifen und/oder die Verpackung (2) eine Markierung, insbesondere einen QR Code aufweist, wobei der sich Testende identifizierbar ist, durch ein mit einem Endgerät (7) aufgenommenes aktuelles Foto und einer Ablichtung eines Identitätsnachweises, wobei eine AI die Identität verifiziert und durch Eingabe des Ergebnisses des Covid-Tests ein Testergebnis (11) erzeugbar ist, welches auf dem mobilen Endgerät (7) wiedergegeben ist.

VERFAHREN UND SYSTEM ZUR QUALITÄTSVERWALTUNG IN THERAPEUTISCHEN PROZESSEN

Identification modules for exchangeable components in analytical instruments

The modules for the identification of disposable and exchangeable components (46,47,55,58,62,63,69) in analytical instruments (41,42,43,44), particularly in complex analytical systems (40), consists of identification modules (48,49,56,58,64,66,72) mounted on each component, each with its respective transmitter/receiver (50,51,59,60,65,67,71). These transmitter/receivers obtain information signals from the modules and can transmit signals to them. They are linked to the electronic equipment within each instrument (52,61,68,72) and through a lead (53) to a control unit (54). This control unit evaluates the information received from each module and displays information whenever a particular component fails to meet required performance criteria. This enables speedy recognition of the need to change components.

Verfahren und Mikroskopiersystem zum Scannen einer Probe

Verfahren zum Scannen einer Probe mittels eines elektrisch und/oder elektronisch steuerbaren Mikroskops, wobei eine Vielzahl von Bildern, insbesondere digitalen Bildern, an unterschiedlichen Stellen der Probe und/oder zu unterschiedlichen Zeiten erzeugt wird und wobei das Mikroskop während des Scanvorgangs durch einen Steuerrechner gesteuert wird, dadurch gekennzeichnet, dass ein von dem Mikroskop erzeugtes Bild an mindestens einen von mehreren weiteren Rechnern übertragen wird, die untereinander und mit dem Steuerrechner über ein Netzwerk oder Teile eines Netzwerks verbunden sind, dass eine automatische Analyse übertragener Bilder durchgeführt wird, dass bedarfsgerecht zur Laufzeit des Scanvorgangs weitere Rechner zugeschaltet oder getrennt werden, so dass die erzeugten Bilder parallel und im Wesentlichen zeitgleich oder zeitnah zum Scanvorgang analysiert werden, und dass basierend auf den Ergebnissen der Analyse eine Klassifikation der Bilder vorgenommen und der Scanvorgang beeinflusst ...

Tracking of physiological or medicinal samples

Method and system for collection and verification of data from plural sites

Systems and methods of conducting clinical research

Methods, devices, and systems for detecting anolyte levels

The present disclosure describes a method of quantifying analyte levels using gold nanoparticles. The present disclosure also describes a device to quantify analyte levels using gold nanoparticles and image processing of pixels isolated from a single vector. The methods, devices, and systems of the disclosure can be used to quantify analytes such as luteinizing hormone, progesterone, estradiol, or testosterone.

Method and System relating to a Laboratory Product

Methods and systems for analyzing nucleic acid molecules

Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.

Method for the cytometric analysis of cell samples

A method for the cytometric analysis of cell samples, wherein the microscope is capable of operating in a transmis­sion mode and/or in a fluorescence mode. The cell sample has a fluorescence marker. During a continuous movement of the cell samples, a first image of a sub-region of the cell sample is recorded in transmission or fluorescence mode; and a second image of the cell sample is recorded in fluorescence mode. The two images are associated with each other. Positions and/or con­tours M of cells or cell components of the cell samples are detected in the transmission image. The in­tensities of the fluorescence image are then analysed as a function of these positions and/or contours M. Alternatively, positions and/or contours M are extracted from any one of these two images, and the remaining image is analysed as a function of these positions and/or contours.

Spectrometric analysis

A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.

Personalized medication management and alert system and method

Method for evaluating correlations between structured and normalized information on genetic variations between humans and their personal clinical patient data

Methods, devices, and systems for detecting analyte levels

Collision surface for improved ionisation

Spectrometric analysis

A quality control system, method and computer readable medium for use with biological/environmental diagnostic test devices, users and consumables

Remote monitoring of medical devices

A quality control system, method and computer readable medium for use with biological/environmental diagnostic test devices, users and consumables

Remote monitoring of medical devices

Method for taking a sample from a system, e.g. a medical sample, whereby an order placer connects to the analyzing organizations' database to transfer relevant data and receive sampling instructions back

Method whereby at the beginning of the analysis process the requirements of the orderer are supplied via the orderer's computer which connects to a database so that data necessary for the analysis can be transferred to the database. Based on the transferred data and the type of analysis to be carried out the system automatically specifies the type of sample holder to be used. The invention also relates to a corresponding use of the method for taking medical samples, environmental samples or water quality samples.

DIALYSIS EQUIPMENT AND PROCEDURE FOR CONTROLLING THE FUNCTIONALITY OF DIALYSIS EQUIPMENT

VERFAHREN ZUR ERSTELLUNG EINES AUFTRAGSDATENSATZES FÜR EINE ZU ANALYSIERENDE PROBE

ARCHIVES AND ANALYSIS SYSTEM

FORCE OF GRAVITY ATTRACTION MACHINE TO the FLEXIBLE AUTOCCLUSTERING n of DIMENSIONAL DATA STREAMS

PROCEDURE FOR THE ADMINISTRATION FROM CLINICAL LOG DATA TO THE USE IN ACTIVE IMPLANTIERBAREN MEDICAL INSTRUMENTS

VORGEBURTLICHE EXAMINATION OF PREGNANCY ABNORMALITIES

PROCEDURE, DEVICE, MANUFACTURED ARTICLE AND USER SURFACES FOR THE AUTOMATIC DISSECTION OF BIOLOGICAL TESTS AND THE CLEANING OF MACROMOLECULES

Analyte test instrument system including data management system

System and method for collection confirmation and sample tracking at the clinical point of use

A system for confirming acquisition of a fluid sample is provided. The system includes a wearable electronic device configured to be worn by a user. The device has a housing, at least one imaging sensor associated with the housing, a data transmission interface for sending data to or receiving data from an external electronic device, a microprocessor for managing the at least one imaging sensor and the data transmission interface, and a program for acquiring and processing images acquired by the at least one imaging sensor. The system further includes a sampling device for collecting a fluid sample in a sample container and at least one identification tag attached to or integrally formed with the sampling device or sample container. The at least one identification tag includes or is associated with a tracking code. L i I o - ...

History logging for samples of biological material

A method of reducing quality problems associated with patient sample collection and delivery is provided. It is possible that the method can provide a chain of custody process to better track a sample from the initial point of sample collection to the final point of sample testing. Such a method can also include providing an alert to indicate a potential problem with the quality of the diagnostic test result when a measured parameter exceeds a threshold.

Breath selection for analysis

Methods and systems are described to obtain and analyze a gas sample from a desired section of the breath of a person, while accounting for erratic, episodic or otherwise challenging breathing patterns that may otherwise make the capturing of a gas sample from the desired section of breath difficult. These techniques may provide more reliable, accurate and adequate samples of gas such as end-tidal gas, and ultimately an accurate analysis of the sample captured. - 39- ...

Materials and methods relating to dosage regimen design

The present invention provides materials and methods for determining optimal dosage regimens for therapeutic agents. In particular, the invention relates to dosage regimens for therapeutic agents capable of targeting IL-2 receptor, preferably interleukin 2 (IL2)-based therapeutic agents. The methods of the invention allow general dosage regimens to be determined for new IL-2R targeted therapeutic agents but also specifically tailored dosage regimens to be achieved for individuals being treated with IL-2R targeted therapeutic agents.

Compositions and methods for improved creatinine measurement accuracy and uses thereof

The disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving measurement accuracy of electrochemical sensors used for measuring creatinine and creatine.

A Technique for Predicting Acarbose Treatment Based on Stratification of Gut by Using 16SrRNA Sequencing

Abstract Acarbose, as one of the main antidiabetics, plays an important role in type 2 diabetes (T2D) patients. According to a survey, antidiabetic medication may modulate the gut microbiota and after receiving acarbose treatment, patients with rich intestinal Bacteroides receive more metabolic benefits than patients with a gut microbiota dominated by Prevotella. So stratification of T2D patients based on their gut microbiota prior to treatment can effectively increase the curative effects. This invention includes the Acarbose guidance of the T2D population based on a quick and precise stratification of gut types. Based on second-generation sequencing, the invention has the advantages of relatively low cost and high sequencing speed. During the design process, we collect fecal samples and extract total DNA of intestinal microorganisms. Using 16SrDNA amplicon sequencing technology and qiime2 visualization, we can find microbial composition and abundance of each sample. Thenceforth, after ...

Improved healthcare interoperability environment system

The invention concerns an Interoperability Environment comprising: a core software engine comprising means to collect and transfer electronic data from any number of sources including medical devices, clinical information systems, hospital information systems, a means to apply rules to improve compliance with hospital approved protocols, standards and guidances, a means to update all subsystems using any given parameter when the parameter is updated in the official recognized source of truth for that parameter, a means to populate the CIS with all required patient information, while at the same time maintaining all quality and process control data in a format supporting advanced analytics separate from the CIS data, a means to communicate notifications to any number of remote electronic devices without limitation of platform and comprising a hardware eco system comprising means to collect, translate, store and send electronic data to the core software engine for any electronic source via ...

Systems and methods for display device and sensor electronics unit communication

SYSTEMS AND METHODS FOR DISPLAY DEVICE AND SENSOR ELECTRONICS UNIT COMMUNICATION Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

Methods for identifying biological material by microscopy

The present invention relates generally to the field of computer-based image recognition. More particularly, the invention relates to methods and systems for the identification, and optionally the quantitation of, discrete objects of biological origin such as cells, cytoplasmic structures, parasites, parasite ova, and the like which are typically the subject of microscopic analysis. The invention may be embodied in the form of a method for training a computer to identify a target biological material in a sample. The method may include accessing a plurality of training images, the training images being obtained by light microscopy of one or more samples containing a target biological material and optionally a non-target biological material. The training images are cropped by a human or a computer to produce cropped images, each of which shows predominantly the target biological material. A human then identifies the target biological material in each of the cropped images where identification ...

Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster

The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the cluster. The application further relates to screening methods to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.

Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors

System and method for determining individualized medical intervention for a disease state

Decision support system and method for diagnosis consultation in laboratory hematopathology

Test strip container with integrated meter having strip coding capability

A system for diagnostic testing may include a meter for performing a test on a sample applied to a test media and a selectively closable container configured to house test media compatible with the meter. The system may also provide mechanisms for removing a meter from a test container and reattaching it to a new one using one of several coding methods that recalibrate the meter for the new container of test strips. Alternatively, the system may include an auto-calibration system where data is provided individually on each individual test medium in a form readable by the test meter. The carried data may include an embedded code relating to data particular to that individual strip. The data is presented so as to be read by a meter associated with the diagnostic test strip in order to avoid manually inputting the information. In addition, the system may further provide mechanisms to reconfigure the meter to perform a new function when it has been determined that a triggering event has occurred ...

Methods and apparatus for identifying disease status using biomarkers

Collecting and analyzing surface wound data

Methods for the diagnosis of dementia and other neurological disorders

Integrated spectral data processing, data mining, and modeling system for use in diverse screening and biomarker discovery applications

METHOD FOR CARRYING OUT QUALITY CONTROL ON AN ANALYTICAL PROCESS AND DEVICE FOR CARRYING OUT SAID METHOD

Medical product dispensing systems and methods

Methods and systems for transferring restricted distribution medical products to an over-the-counter general sales environment are provided. Methods and systems of dispensing non-prescription, behind-the-counter medical products from a vending machine in a general sales location are also provided. In some embodiments, methods and systems are provided for dispensing a medical product from a vending machine in a general sales location based, at least in part, on biometric data collected from the purchaser and, in some instances, based on self- selection and/or de-selection criteria, is provided. Further, methods and systems of switching prescription medical products to non-prescription, over-the-counter medical products are provided.

Patient medication IV delivery pump with wireless communication to a hospital information management system

Method for automatically seeding previously-classified images among images of objects of interest from a specimen

A computer-assisted method of classifying cytological samples, includes using a processor to analyze images of cytological samples and identify cytological objects of interest within the sample images, wherein the processor (i) displays images of identified cytological objects of interest from the sample images to a reviewer, (ii) accesses a database of images of previously classified cytological objects, and (iii) displays to the reviewer, interspersed with the displayed images of the identified objects of interest from the sample images, one or more images obtained from the database of images of previously-classified objects.

System and method for automatic quality control of clinical diagnostic processes

A system and method to automatically implement quality control of a clinical diagnostic process are disclosed. Upon generation of an internal error Hag, a confirmation rule automatically checks a questionable patient statistic alert by testing a quality control specimen, applying event-related quality control rules to the results of that test, and provides an alert to the operator only upon a confirmed patient signal T he automatic quality control process thus eliminates the uncertainty of operator reaction to an alert signal and implements the quality control run automatically, without operator intervention.

SYSTEM AND METHOD FOR TRACKING AND CONTROLLING INFECTIONS

Disposable audio instruction device and method

Method and means for data management in a laboratory

Systems, methods and kits for remote genetic analysis and consultation

Blood glucose tracking apparatus and methods

TEST RESULT MANAGEMENT SYSTEM, TEST PROCESSOR, TEST RESULT MANAGEMENT METHOD, AND PROGRAM

METHOD AND SYSTEM FOR MONITORING PATIENT CARE

METHODS AND SYSTEMS FOR DONOR SAMPLE MANAGEMENT AND POOLING FOR USE IN PROTEOMIC STUDIES

System and method for assuring patient medication and fluid delivery at the clinical point of use

A system for confirmation of fluid delivery to a patient at the clinical point of use is provided. The system includes a wearable electronic device. The wearable electronic device has a housing; at least one imaging sensor associated with the housing; a data transmission interface; a data reporting accessory for providing data to the user; a microprocessor for managing the at least one imaging sensor, the data transmission interface, and the data reporting accessory; and a program for acquiring and processing images from the at least one imaging sensor. The system further includes a fluid delivery apparatus; and one or more identification tags attached to or integrally formed with the fluid delivery apparatus. The program processes an image captured by the at least one imaging sensor to identify the one or more identification tags and acquires fluid delivery apparatus information from the one or more identification tags.

Encrypted data store for records

A method performed by a processing system includes determining a location in a metadata tree of a patient for an electronic health record, generating a record key for the electronic health record based on the location and a provider key corresponding to a provider, the provider key generated from a patient key corresponding to the patient, encrypting the electronic health record using the record key to generate a encrypted record, and providing the encrypted record to an encrypted data store.

Genes associated with dasatinib sensitivity

Disclosed herein is a panel of seven genes, ...

Safeguarding measures for a closed-loop insulin infusion system

Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains a current insulin on board (IOB) value that estimates active insulin in the user, and compensates a calculated insulin infusion rate in response to the obtained IOB value. A second method supervises the operation of a glucose sensor by obtaining and processing insulin-delivered data and glucose sensor data for the user. An alert is generated if the second method determines that a current glucose sensor value has deviated from a predicted sensor glucose value by at least a threshold amount.

Expert system for determining patient treatment response

A medical digital expert system to predict a patient's response to a variety of treatments (using pre-treatment information) is described. The system utilizes data fusion, advanced signal/information processing and machine learning/inference methodologies and technologies to integrate and explore diverse sets of attributes, parameters and information that are available to select the optimal treatment choice for an individual or for a subset of individuals suffering from any illness or disease including psychiatric, mental or neurological disorders and illnesses. The methodology and system can also be used to determine or confirm medical diagnosis, estimate the level, index, severity or critical medical parameters of the illness or condition, or provide a list of likely diagnoses for an individual suffering/experiencing any illness, disorder or condition.

Methods for profiling and quantitating cell-free RNA

The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of RNA in a biological sample, comparing the sample level of RNA to a reference level of RNA specific to the tissue, determining whether a difference exists between the sample level and the reference level, and characterizing the tissue as abnormal if a difference is detected.

Integrated blood glucose measurement device

Laboratory instrumentation information management and control network

Described are techniques for identifying samples processed in a laboratory using harmonized identifier. A case identifier identifying a patient from whom a specimen is collected is determined. A specimen identifier associated with the specimen is determined. An entry for the specimen is recorded in a data store where the entry being associated with the case identifier and the specimen identifier. A harmonized specimen identifier including the case identifier and the specimen identifier is formed. The specimen is labeled with the harmonized specimen identifier.

System and method for determining sigma of a clinical diagnostic process

A system and method for determining a sigma of a clinical diagnostic process are disclosed. Specimen data are collected from a plurality of laboratory instruments. The specimen data are evaluated to determine a concentration and an analytical standard deviation for each data point. A clinical diagnostic process is run and patient analyte values are acquired, and a standard deviation is assigned to each patient analyte value based on the standard deviation of specimen data having a corresponding concentration. A single sigma-metric is computed based on the patient analyte assigned standard deviations, the sigma- metric representing the sigma of the clinical diagnostic process. The computed sigma-metric is reported to a user or laboratory manager.

Subcutaneous outpatient management

A method (1300) of administering insulin includes receiving subcutaneous information (216, 216a) for a patient (10) at data processing hardware (112, 132, 142, 192, 160) and executing a subcutaneous outpatient process (1800, 1800a, 1800b) for 5 determining recommended insulin dosages (2310, 2402, 2404, 2406). The subcutaneous outpatient process includes obtaining blood glucose data of the patient from a glucometer (124), aggregating blood glucose measurements to determine a representative aggregate blood glucose measurement (2310, 2402, 2404, 2406) associated with at least one scheduled blood glucose time interval, and determining a next recommended insulin 10 dosage (2310, 2402, 2404, 2406) for the patient based on the representative aggregate blood glucose measurement and the subcutaneous information. The method also includes transmitting the next recommended insulin dosage to a portable device (1 Oa, 1 Ob, 123a, 123b, 124) associated with the patient. The portable device displays the ...

Providing a pharmacokinetic drug dosing regimen

A system and method for providing a therapeutic plasma protein dosing regime includes determining a pharmacokinetic profile of a patient using a Bayesian model of pharmacokinetic profiles of sampled patients. The example system and method also include determining a first dosing regime for a first specified dosing interval including (i) a first dosage and (ii) a first therapeutic plasma protein level in the patient over a time period based at least upon the pharmacokinetic profile and determining a second dosing regime for a second specified dosing interval including (i) a second dosage and (ii) a second therapeutic plasma protein level in the patient over the time period based at least upon the pharmacokinetic profile. The example system and method further include displaying the first dosing regime and the second dosing regime on a client device such that the first dosing regime is displayed in conjunction with the second dosing regime.

Information processing apparatus and method for clinical laboratory management

To facilitate management of the entirety of one or a plurality of clinical laboratories. This information processing apparatus 5 is used in management of a clinical laboratory in which an analyzer configured to analyze specimens is installed. The information processing apparatus 5 includes: a communication section 50 configured to communicate with a terminal 6 operable by a user; and a controller 51 configured to control display of the terminal 6 via the communication section 50. On the basis of information collected from a plurality of analyzers 10 installed in one or a plurality of clinical laboratories and from apparatuses 11, 12, 13, and 14 relevant to the analyzers 10, the controller 51 causes the terminal 6 to display a screen including an index that indicates a status of the entirety of the one or the plurality of clinical laboratories. In response to the user selecting the index displayed in the screen, the controller 51 causes the terminal 6 to display the selected index so as ...

Method and system for patient-specific modeling of blood flow

C:\Users\kll\AppData\Local\Temp12713 IDAOBAFC.DOCX-22 12/2015 Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

SIZE-BASED ANALYSIS OF FETAL DNA FRACTION IN MATERNAL PLASMA

A fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes. For example, the fractional concentration of fetal DNA in maternal plasma or tumor 5 DNA in a patient's plasma can be determined. The size of DNA fragments in a sample is shown to be correlated with a proportion of fetal DNA and a proportion of tumor DNA, respectively. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a size parameter and the fractional concentration of the clinically-relevant DNA. For a given sample, a first value of a size parameter can be 10 determined from the sizes of DNA fragments in a sample. A comparison of the first value to the calibration data points can provide the estimate of the fractional concentration of the clinically-relevant DNA. 8763586_1 (GHMatters) P93030.AU.1 ...

Method and system for patient-specific modeling of blood flow

Abstract A system for determining cardiovascular information for a patient, the system comprising: at least one computer system configured to: receive patient specific data regarding a geometry of an anatomical structure of the patient; create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet; create at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, based at least in part on modeling a condition of hyperemia; and determine first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three dimensional model and the at least one boundary condition model. cCD Co co VC C C) C) f I co C, Loij 0~ u~ EtIt C3oI ...

Laboratory instrument control system

... 35551999 div specifcaion(2098914L1)doc A server computer system comprising: a processor configured to control communication with and control at least two virtual pods which comprise a first virtual pod and a second virtual pod, wherein the first virtual pod comprises a first set of at least two biological reagent instruments from among a plurality of biological reagent instruments and a first dedicated user interface (UI) instance, to be displayed by a client computer device, wherein the first dedicated UI instance controls said at least two of the plurality of biological reagent instruments and the second virtual pod comprises a second set of at least two other biological reagent instruments from among the plurality of biological reagent instruments and a second dedicated UI instance, to be displayed by the client computer device, wherein the second dedicated UI instance controls the second set of the at least two other biological reagent instruments, wherein the processor is further configured ...

ELECTRONIC DELIVERY OF INFORMATION IN PERSONALIZED MEDICINE

According to an aspect of an embodiment, a method of delivering information enabled personalized healthcare in a clinical, non-research setting may include capturing one or more data streams where each of the data streams relates to health care of a patient. 5 The method may further include integrating the data streams to generate integrated diagnostic data and analyzing the integrated diagnostic data to generate analyzed diagnostic data. The method may further include curating the analyzed diagnostic data and generating an integrated report for presentation to a physician of the patient based on the curated analyzed diagnostic data.

DELIVERING AND/OR RECEIVING FLUIDS

The present application generally relates to receiving bodily fluid through a device opening. The device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator.

Programmable voice instructed medication delivery and outcomes monitoring system

Methods and devices for identifying patterns in biological systems and methods for uses thereof

System for tracking secure medical test cards

Marker adapted normal tissue complication probability

A therapy system includes a diagnostic image scanner ( 12 ) that acquires a diagnostic image of a target region to be treated. A planning processor ( 70 ) is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device ( 40 ) administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device ( 40 ) administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.

Method, System, and Computer Program Product For The Evaluation of Glycemic Control in Diabetes From Self-Monitoring Data

A method, system, and computer program product related to the diagnosis of diabetes, and is directed to predicting the long-term risk of hyperglycemia, and the long-term and short-term risks of severe hypoglycemia in diabetics, based on blood glucose readings collected by a self-monitoring blood glucose device. The method, system, and computer program product pertain directly to the enhancement of existing home blood glucose monitoring devices, by introducing an intelligent data interpretation component capable of predicting both HbA 1c and periods of increased risk of hypoglycemia, and to the enhancement of emerging continuous monitoring devices by the same features. With these predictions the diabetic can take steps to prevent the adverse consequences associated with hyperglycemia and hypoglycemia.

Integrated display and control for multiple modalities

A system and method of managing an integrated laboratory for diagnosing and treating a patient is described. The system is divided into a laboratory room and a cockpit control room. The cockpit control room has a plurality of workstations for display and control of the laboratory equipment, so that two operators may cooperate in operating the equipment without conflict. All of the needed data is displayed to each operator in a single display where the display area is divided by a predetermined selectable grid pattern. The equipment in the laboratory room and the cockpit control room connected by electrically isolated paths. A backup workstation is provided, where at least the essential laboratory equipment is connected using an independent electrically isolated path.

Method and System For Patient-Specific Modeling of Blood Flow

Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and information regarding a physiological condition of the patient. The at least one computer system may be further configured to receive input from a user regarding a plan of treatment, modify the physiological condition of the patient based on the received input, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified physiological condition of the patient.

Information Processing System Using Nucleotide Sequence-Related Information

A system for processing information for providing semantic information and/or information associated with the semantic information useful for each individual organism through effective utilization of differences in nucleotide sequence-related information among individual organisms is constructed. The method for processing information on a nucleotide sequence comprises: (a) receiving request information for an object and/or service; (b) obtaining positional information in accordance with the request information from a memory having positional information representing a position in a nucleotide sequence memorized therein; and (c) obtaining nucleotide sequence-related information corresponding to the positional information obtained in (b) above, and obtaining semantic information implied by the nucleotide sequence-related information and/or information associated with the semantic information.

Method And Apparatus For Providing Data Processing And Control In A Medical Communication System

Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Simultaneous determination of aneuploidy and fetal fraction

The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained form a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.

Automated Medical Matrix for Diagnosing and Scheduling Patients

The present invention is comprised of an automated medical matrix for diagnosing and scheduling patients for providing automated treatment selection cross referenced to a diagnosis, ordering, scheduling and insurance health plan pre-approvals within a medical center such as a surgery center or hospital. The present invention is further comprised of an automated treatment outcome results scoring system to rank the most effective treatment available being used in a medical center. The present invention is further comprised of modules that automatically coordinates treatment appointments between various medical center departments and automatically completes forms preparations for ordering the treatment, get insurance plan pre-approvals and billing processes to reduce staff time to perform the same tasks manually and increase effective treatment selection, shorten patient waiting time for treatments and reduce liability risk of poorly selected treatments.

Automatic analyzing device

In order to improve work efficiency, to exclude human mistakes, and to improve analysis efficiency, an automatic analyzing device that analyzes blood and urine includes a bar code reader and an RFID reader that reads identification information relating to the samples and reagents and that is installed in an operating unit for managing analyzing units in an integrated manner. Test information is stored in a test information storage means of the operating unit and when the identification information stuck on containers of the samples or the reagents is read, the test information is searched. The test information is displayed on a screen of the operating unit as search results; and a function of switching from the search results displayed on the screen to a detailed screen that displays details of the test information when a user selects target test information is provided.

Method for automatically seeding previously-classified images among images of objects of interest from a specimen

A computer-assisted method of classifying cytological samples, includes using a processor to analyze images of cytological samples and identify cytological objects of interest within the sample images, wherein the processor (i) displays images of identified cytological objects of interest from the sample images to a reviewer, (ii) accesses a database of images of previously classified cytological objects, and (iii) displays to the reviewer, interspersed with the displayed images of the identified objects of interest from the sample images, one or more images obtained from the database of images of previously-classified objects.

Analyzing method and system for test strips

An exemplary test strip reading and analyzing system includes a test strip unit, a mobile device and a remote computing apparatus. The test strip unit includes at least one tested-object reacting region. The mobile device includes an image capture module for capturing a test-strip image of the test strip unit and a transmission module electrically coupled to the image capture module. The remote computing apparatus, installed with a test strip analyzing system, is for analyzing the test-strip image and accordingly generating an test report. The test-strip image captured by the image capture module is transmitted to the remote computing apparatus through the transmission module; and the test report generated by the remote computing apparatus is consequently transmitted to the mobile device.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Method for managing treatment of a patient health condition with a pda based system

A method for managing treatment of a particular health condition afflicting a patient through the use of a PDA which includes a health management program stored in the PDA that prompts a user for entry of health condition data, including patient physiological data, subjective patient health condition data, and medication delivery data, compiles the health condition data into an accumulated data summary, and transmits the data summary from the PDA to a second processing unit through a communication port. A drop-down list related to subjective symptoms is provided, which includes stress and depression. A touch screen is provided for a graphical user interface. The health management program also provides prompts for the entry of diet data, and further displays drop-down lists related to daily activities and alerts for medication delivery.

Data management computer, sample analyzing system, and computer program

A data management computer for a sample measuring apparatus is disclosed. The computer comprises a data storage, a display section; an input device; and a controller. The data storage stores results of measurements for a sample obtained by the sample measuring apparatus, the measurements including an initial measurement for a sample and a secondary measurement which is performed on the sample following the initial measurement. The controller is programmed to cause the display section to display a first result screen which shows a result of the initial measurement for a sample, receive a predefined operation by use of the input device while displaying the first result screen, and cause the display section to display, in a response to the predefined operation, a second result screen which shows a result of the secondary measurement for the sample.

Method and Apparatus for Providing Data Processing and Control in a Medical Communication System

Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Integrated delivery device for continuous glucose sensor

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

Decision Management System to Define, Validate and Extract Data for Predictive Models

The present invention provides a decision management system to define, validate and extract data for predictive models. A system of sensors is deployed in a sample collection environment, where such sensors are used to collect data from a biological or chemical sample, with additional sensors for ambient data whose output as a form of metadata can characterize performance conditions including background ambient conditions. A format or sequence of processes is the basis for a math model to establish a logical weight to data for predictive modeling and event reporting. The present invention provides a computer or other sensor interface system with a primary sensor or sensors, network connection, and supplementary sensors to measure the conditions in which the primary data is captured. A software process allows for user inputs of data in order to establish the methods and rules for normal function.

Methods for placing, accepting, and filling orders for products and services

Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer.

Method and system for generating personal/individual health records

A system and method for generating and/or updating a personal/individual health record. Inputs of data to the system may come from diverse sources including, but not limited to, patient questionnaires, insurance company (or other payor) claims data, hospitals, clinics and other institutional providers, and individual physicians and physicians' offices.

Automated high-throughput flow-through real-time diagnostic system

An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system.

Method for quantifying the extent of human-introduced variability in medical test data

A method for quantifying the extent of human-introduced variability in medical test data relative to one or more standards for comparable medical tests, the method comprising the following steps: providing user medical test data; comparing the user medical test data against one or more standards for comparable medical tests to determine the extent of deviation of the user medical test data from the one or more standards; and generating a variability-value corresponding to the maximum absolute percentage deviation of the user medical test data from the one or more standards over a predefined operating range of values for the one or more standards.

Methods For Delivering A Drug To A Patient While Restricting Access To The Drug By Patients For Whom The Drug May Be Contraindicated

Methods for delivering a drug to a patients in need of the drug, while restricting access to the drug by patients for whom the drug may be contraindicated are disclosed. The methods are of the type in which prescriptions for the drug are filled by a pharmacy only after a computer readable storage medium has been consulted to retrieve a prescription approval code. Embodiments are provided wherein the patients are assigned to risk groups based upon the risk that taking the drug will lead to an adverse side effect, and certain additional information, such as periodic surveys and diagnostic tests probative of the ongoing risk of the side effect developing are obtained before prescriptions for the drug are approved.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Automated device for a biologic drug distribution

The present disclosure relates to an apparatus for dispensing biologic drug compositions. The apparatus includes an automated device that can store a biologic drug under the desired conditions. When authorized, the automated device can process the stored biologic drug by performing the desired processing steps to prepare the biologic drug for administration to a patient. The automated device may include a computing system to transmit patient information to a remote location and receive authorization from a remote location.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Method of displaying patient data in a medical workflow environment

An apparatus, a method and a system for displaying patient data in a medical workflow environment are disclosed. The method includes scanning a patient identifier with a hand-held device, displaying patient data on a display screen of the hand-held device, selecting a medication for administration to the patient from a list of one or more medications displayed on the display screen, scanning a medication identifier with the hand-held device, and confirming administration of the medication on the hand-held device

Delivering and/or receiving fluids

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

Disease simulation system and method

A method of diabetes management including receiving a plurality of readings over time from an analyte sensor, processing each of the readings to generate analyte data, receiving information about external factors, using the analyte data to estimate an amount of medication to be dispensed from a single dose medication device based on the analyte data in combination with the external factors, and displaying an instruction to deliver the amount of medication.

Systems, methods, and media for laboratory testing services

Systems, methods, and media for laboratory testing services are disclosed. Medical information can be received from an electronic device. One or more laboratory tests can be recommended based at least in part on the received medical information. For example, if one or more symptoms are received, then one or more laboratory tests may be suggested based at least in part on the received symptoms. As another example, if an order for one or more laboratory tests are received, then one or more additional and/or alternative laboratory tests may be suggested. Suggested laboratory tests can be based on medical symptoms, medical conditions, medical codes, medical history, medications, laboratories, healthcare providers, insurance companies, financial factors, locations, turnaround time, other factors, or a combination thereof. One or more of the suggested laboratory tests can be ordered.

Multiple wavelength sensor emitters

A physiological sensor has light emitting sources, each activated by addressing at least one row and at least one column of an electrical grid. The light emitting sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.

Apparatus, method and article to perform assays using assay strips

An assay system includes an optical imager to acquire high resolution images of assay strips (e.g., lateral flow immunochromatographic test strips) and performs image processing to identify individual assay strips and determine results for each assay strip, by quantifies the presence or absence of test signal line(s) and control signal line(s). Assay strips may be in a holder or carrier contained in a specimen container also holding a specimen. The assay system automatically logs all results and data to a database that stores a high resolution image of the original immunochromatographic assay, the values of test line(s) and control line(s), and the test result. A user interface directs an end user through operation.

Glucose Measuring Device Integrated Into A Holster For A Personal Area Network Device

A glucose meter module integrated into a holster device that can securely accommodate another device such as a portable server device or an insulin pump is described. The glucose measuring module and the health device communicate with each other by a short range wireless modality. In the case in which the accommodated device is a server, such as personal digital assistant or cell phone, the device stores data in a memory, displays data on a visual display, and can wirelessly transmit such data to other devices within a personal area network. In the case where the accommodated device is a cell phone, the phone can further transmit data to remote sites. In the case where the accommodated device is an insulin pump, wirelessly received data are stored in a memory, are available for visual display on the insulin pump, and can be incorporated into the electronic processes that regulate the performance of the pump.

Analyte testing method and system with high and low analyte trends notification

Described herein are systems and methods to utilize factual information based on stored analyte data to allow greater insight into the management of diabetes of a user.

Identifying patient eligibility for clinical trials

Systems and method for facilitating clinical-trial referrals are provided. In embodiments, the method includes searching clinical-trial data associated with a plurality of clinical trials to identify one or more clinical trials for which a patient is eligible to participate based on patient data associated with the patient. Such clinical-trial data associated with the plurality of clinical trials can be aggregated in a centralized data store. Thereafter, an indication of the one or more clinical trials for which the patient is eligible is provided.

Membrane separation devices, systems and methods employing same and data management systems and methods

A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

Method and Device for Providing Offset Model Based Calibration for Analyte Sensor

Methods and devices to detect analyte in body fluid are provided. Embodiments include processing sampled data from analyte sensor, determining a single, fixed, normal sensitivity value associated with the analyte sensor, estimating a windowed offset value associated with the analyte sensor for each available sampled data cluster, computing a time varying offset based on the estimated windowed offset value, and applying the time varying offset and the determined normal sensitivity value to the processed sampled data to estimate an analyte level for the sensor.

Sample processing method, device and system for an assembly line workstation

A method of processing a sample for an assembly line workstation for a body fluid test includes: receiving application information including a sample number; checking a sample of a sample rack to acquire a sample checking result; matching the sample checking result with the sample number to determine if a match succeeds; and if a match is not successful, pausing dispatch of the sample rack.

System and method for remote control of a microscope

A system and method for remote control of an automated microscope via a widely distributed network.

Safeguarding measures for a closed-loop insulin infusion system

Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains a current insulin on board (IOB) value that estimates active insulin in the user, and compensates a calculated insulin infusion rate in response to the obtained IOB value. A second method supervises the operation of a glucose sensor by obtaining and processing insulin-delivered data and glucose sensor data for the user. An alert is generated if the second method determines that a current glucose sensor value has deviated from a predicted sensor glucose value by at least a threshold amount.

Integrated lab management system

The present invention provides an online virtual laboratory manager that allows for electronic documentation and management of all aspects of the laboratory. The system receives data from one or more instruments in a laboratory and stores the data in a central library. The data is compared against compliance target values to determine if the one or more instruments are in compliance, and if the data is out of the compliance target values, notifying a laboratory manager. In notifying the laboratory manager, the laboratory manager is provided with corrective actions that are required, and thereafter, the system documents any data changes that occur. Additionally, the data from a plurality of laboratories is stored in the central laboratory to allow for peer review across laboratories. The system allows for monitoring the laboratory, identifying and fixing issues, and document all aspects for regulatory compliance, including allowing instant regulatory access to laboratory logs.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Health Management Devices and Methods

Methods and devices and systems including a communication module operatively coupled to a data collection module for communicating the stored analyte related data after the analyte related data is stored in the data collection module over a predetermined time period, and a user interface unit configured to communicate with the communication module to receive from the communication module the stored analyte related data in the data collection module over the predetermined time period, and to output information associated with the monitored analyte level, where the user interface unit is configured to operate in a prospective analysis mode including substantially real time output of information associated with the monitored analyte level, or a retrospective analysis mode including limited output of information during the predetermined time period wherein no information related to the monitored analyte level is output during the predetermined time period, are provided. 1. An analyte monitoring system , comprising:a transcutaneous analyte sensor configured to be positioned at least in part in contact with a fluid under a skin layer and to generate analyte data over a predetermined time period;a data collection module operatively coupled to the transcutaneous analyte sensor for receiving and storing the analyte data over the predetermined time period;a control unit operatively coupled to the data collection module and configured to control, at least in part the operation of the data collection module;a communication module operatively coupled to the control unit, the communication module configured to communicate the analyte data; anda receiver unit operatively coupled to the communication module and configured to receive the analyte data,wherein the receiver unit is configured to display information related to the analyte monitoring system and is configured to not display the analyte data.2. The system of claim 1 , wherein the communication module is configured to ...

METHOD AND SYSTEM FOR IMAGE PROCESSING TO DETERMINE BLOOD FLOW

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model. 1184-. (canceled)185. A method for processing images to determine cardiovascular information , comprising the steps of:receiving image data including a plurality of coronary arteries originating from an aorta;processing the image data to generate three-dimensional shape models of the coronary arteries;simulating a blood flow for the generated three-dimensional shape models of the coronary arteries; anddetermining a fractional flow reserve (FFR) of the coronary arteries based on a blood flow simulation result, wherein in the step of simulating the blood flow, a computational fluid dynamics model is applied to the three-dimensional shape models of the coronary arteries, a lumped parameter model is combined with the computational fluid dynamics model, and a simplified coronary artery circulation model including coronary arteries, capillaries of the coronary arteries and coronary veins is used as the lumped parameter model.186. The method of claim 185 , wherein claim 185 , when simulating the blood flow claim 185 , when applying the computational fluid dynamics model to the three-dimensional shape models of the coronary arteries claim 185 , using an aorta blood pressure pattern as an inlet boundary condition.187. The method of claim 185 , wherein simulating the blood flow comprises determining lengths of centerlines of the three- ...

MANGANESE-BASED CHELATE CONJUGATES FOR MOLECULAR MR IMAGING

Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presence of biochemical targets. 228.-. (canceled)30. (canceled)31. (canceled)3343.-. (canceled)52. The compound of claim 49 , wherein Ris 1 claim 49 ,2-cyclohexylene claim 49 , Ris H claim 49 , Ris H claim 49 , DG is Formula II claim 49 , Q is CH claim 49 , the Y positioned α- to Q is C-[L]-TBM claim 49 , and all other Y are CH claim 49 , and L is —C(O)—.54. A method of magnetic resonance (MR) imaging a patient claim 49 , the method comprising:{'claim-ref': {'@idref': 'CLM-00049', 'claim 49'}, 'a) administering to the patient an effective amount of a compound of ; and'}b) acquiring an MR image of the patient.55. The method of claim 54 , wherein the method is for imaging a tumor claim 54 , a blood clot claim 54 , or a brain lesion in a patient.56. (canceled)57. (canceled)58. A method for detecting the presence or absence of disrupted blood-brain-barrier in a patient claim 54 , the method comprising:{'claim-ref': {'@idref': 'CLM-00049', 'claim 49'}, 'a) administering to the patient an effective amount of a compound of ;'}b) acquiring a first MR image of the brain of the patient;c) acquiring a second MR image of the brain of the patient; andd) comparing the images.59. A method for detecting the presence or absence of arterial stenosis in a patient claim 54 , the method comprising:{'claim-ref': {'@idref': 'CLM-00049', 'claim 49'}, 'a) administering to the patient an effective amount of a compound of ;'}b) acquiring a first MR image of the arteries of a patient;c) acquiring a second MR image of the arteries of patient immediately after injection of the compound; andd) comparing the images. This application claims priority to U.S. Provisional Application Ser. No. 62/204,519, filed on Aug. 13, 2015, and U.S. Provisional ...

Traceable labeling apparatus for containers of biological products

An apparatus for identifying a patient and marking containers of biological products or test tubes ( 13 ) associated with said patient before collecting said biological products to be analyzed is described, comprising a high security portable hardware device ( 1 ) for processing and storing the patient's data capable of associating the patient's personal data and biometric data, a reading and patient biometric recognition device ( 2 ) of said portable hardware device, a personal computer ( 4 ) interacting with an operator and connected to a local communications network ( 50 ) for exchanging information with remote data storage means ( 3 ), one or more computerized labeling machines ( 5 ) of test tubes ( 13 ), each comprising a printer ( 11 ) of barcodes onto labels ( 10 ) adapted to receive printing commands after comparing expected and detected specimens ( 13 ) accommodated in a positioning and recognition device ( 12 ) supported by said labeling machine ( 5 ) and applying said labels ( 10 ) to said test tubes ( 13 ). Each of said labeling machines ( 5 ) comprises a processing and control board ( 6 ) provided with a univocal address within said local communications network ( 50 ), which can be recalled by said operator by typing into a browser of said personal computer ( 4 ), said processing and control board ( 6 ) being capable of exchanging information with said remote data storage means ( 3 ) and with said personal computer ( 4 ), and on the basis of said information, as well as that received after said comparison operated by said positioning and recognition device ( 12 ), of sending said print commands to said printer ( 11 ) included in said labeling machine.

DEVICE, SYSTEM AND PROCESS FOR ROBOTIC RADIOBIOLOGY

A high throughput automated assay platform for temporal image processing of cell growth and colony formation before and after radiation therapy treatments. The platform is designed to compute and monitor a therapeutic protocol by measuring sensitivity of cell growth to treatment based on a radiation therapy protocol. The platform is designed to detect relationships between the temporal images being tracked to colony formation behaviour. 1. A high throughput radiobiology assay platform comprising:a programmable cell loading system for loading concentrations of cells;an imaging interface for receiving temporal images of growth of the cells over time before and after therapy;an image processor for processing the temporal images to detect relations between the images to track colony formation behaviour from said growth of the cell over time and computing a likelihood of survival of a type of said cells after the therapy to a specific dose;a data storage device for generating and storing data structures for the images and tracked colony behaviour; anda therapy system for triggering delivering of the therapy to said cells based on a therapeutic protocol for the specific dose, the therapy system capable of applying different doses to different cells or groups of said cells based on the therapeutic protocol.2. The platform of claim 1 , the image processor for further processing the temporal images of the colony formation to measure sensitivity of said cells to the therapy claim 1 , the data storage device for storing claim 1 , in the data structures claim 1 , the measured sensitivity of said cells to the therapy.3. The platform of claim 1 , further comprising a system for testing a therapy in a variety of environmental oxygen conditions.4. The platform of claim 3 , the image processor for further processing the temporal images of colony formation to measure sensitivity of said cells to both the therapy and a radiation therapy claim 3 , the data storage device for storing ...

Compositions and methods for diagnosing urinary tract infections

Provided herein are compositions and methods for diagnosing urinary tract infections. In particular, provided herein are compositions and methods for preparing canine urine samples and performing Raman spectroscopy detection of urinary tract infections in the samples.

Control system

The application presented herein focuses on the gas flow control for the evaluation of lactose intolerance but is also consistent with flow control required in diverse applications such as, but not limited to: analysis of other disease states (either using chemical markers or using naturally occurring chemical composition analysis) from breath samples, analysis of chemical concentrations of contaminants in naturals gas production/delivery and in petrochemical processing, analysis of air samples for the detection of drugs and or explosives, detection of chemical composition for the optimization of growth of biological species and or compounds such as in fish farming and or phyto-plancton farming, and finally in the detection of release of carbon dioxide in the determination of an earthquake event.

Portable analytical device

A portable analytical device includes a housing, a measuring facility and a processor in the housing, and an electrical connector coupled to the housing and having one end electrically connected to the processor and an opposite end extending outwardly from the housing. The measuring facility is configured to analyze an optical or electrochemical change in the test element having received a liquid sample of the body fluid and to generate measuring values resulting from the analysis. A memory has stored therein software at least a portion of which is executable by the processor to process the measuring values to produce analytical measuring data taking into account calibration values. The electrical connector may be a male universal serial bus (USB) electrical connector, a Type-A USB electrical connector or a mini-USB electrical connector having electrical connections for electrical power, ground, data and ID.

DISEASE DIAGNOSIS USING SPECTROSCOPY AND MACHINE LEARNING

Aspects of the present application relate to techniques of diagnosing whether a pathogen (e.g., SARS-CoV-2) is present in a subject using infrared (IR) spectroscopy and machine learning techniques. The techniques use spectral data obtained from performing IR spectroscopy on a biological sample (e.g., saliva or nasal sample, or genetic material extracted therefrom) to generate a set of feature values. The feature values are provided as input to a machine learning model to obtain output indicating whether the pathogen is present in the biological sample. The output of the machine learning model may be used to determine a diagnosis result for a subject. 1. A method of training a machine learning model for diagnosing whether a pathogen is present in a subject , the method comprising: obtaining spectral data obtained from performing IR spectroscopy on biological samples obtained from a plurality of subjects, wherein the spectral data comprises, for each of the plurality of subjects, light intensity measurements for a plurality of wavelengths of light;', 'generating a set of training data using the spectral data; and', 'training the machine learning model using the training data, the training comprising determining a set of features for the machine learning model, wherein the set of features has a number of dimensions that is less than a number of the plurality wavelengths., 'using a processor to perform2. The method of claim 1 , wherein determining the set of features comprises determining a subset of wavelengths of the plurality of wavelengths that indicate a spectral signature of the pathogen.3. The method of claim 2 , wherein determining the subset of the plurality of wavelengths to be the set of features comprises determining less than 100 of the plurality of wavelengths to be the set of features.4. The method of claim 2 , further comprising determining the subset of wavelengths at least in part by performing mixed integer optimization to identify the subset of ...

Influenza Status Registry

An influenza Status Registry (ISR) that provides a method of acquiring, storing and displaying a person's status regarding influenza, particularly the COVID-19 coronavirus, as well as vaccination information. The ISR uses a software program that operates on a computer or a wireless device such as a smart phone or tablet computer. A person will have an influenza/COVID-19 test performed by a medical professional. The test results, which show the person's status, are then displayed on the computer or wireless device. Any business or other entity where multiple people congregate in a limited space then uses the ISR to determine if it is safe to allow each person to enter the location. The status will be displayed as never had, previously had or currently has influenza/COVID-19, and appropriate action can be taken based on the test results. Additionally, the ISR will display information pertaining to a person's vaccination status. 1. An Influenza Status Registry (ISR) comprising the following steps:create a software program pertaining to influenza test results,download the software program to a computer or wireless device,perform a test to determine a person's influenza status,upload test results to the ISR software program, anddisplay test results to a selected entity.2. The Influenza Status Registry of claim 1 , wherein the influenza is comprised of COVID-19 coronavirus.3. The Influenza Status Registry of claim 1 , wherein the person's influenza status is selected from the group consisting of person previously had influenza claim 1 , person has not had influenza claim 1 , and person currently has influenza.4. The Influenza Status Registry of claim 4 , wherein the influenza status disclosing a person previously had influenza or person currently has influenza further comprises information disclosing type of symptoms a person experience or is experiencing claim 4 , or if a person is asymptomatic.5. The Influenza Status Registry of claim 1 , wherein the uploaded test ...

DIFFRACTION-BASED GLOBAL IN VITRO DIAGNOSTIC SYSTEM

An in vitro human-tissue analysis and communication system produces a quantitative diagnostic indicator for in vitro human-tissue analyzed by the system. The system includes a human-tissue-analyzer subsystem with at least one human-tissue analyzer that analyzes in vitro samples of human tissue and produces a quantitative-diagnostic indicator of each sample. The system also includes a two-way communication subsystem that allows the human-tissue-analyzer subsystem to send and receive information relevant to the quantitative-diagnostic indicators. The human-tissue-analyzer subsystem includes at least one tissue diffractometer operatively coupled to a computer database over a network, and configured for acquisition of the in vitro samples, and transfer of the corresponding human-tissue data to the computer database over the network. A computer processor is operatively coupled to the tissue diffractometer, and receives, transmits and processes the human-tissue data using a data analytics algorithm that provides a quantitative-diagnostic indicator of the in vitro sample of human tissue. 1. An in vitro human-tissue analysis and communication system that produces a quantitative diagnostic indicator for in vitro human-tissue analyzed by the system , comprising: a human-tissue-analyzer subsystem that includes at least one human-tissue analyzer constructed to analyze in vitro samples of human tissue and to produce a quantitative-diagnostic indicator of each sample; and a two-way communication subsystem constructed to allow the human-tissue-analyzer subsystem to send and receive information relevant to the quantitative-diagnostic indicators.2. The system of claim 1 , wherein the human-tissue-analyzer subsystem includes at least one tissue diffractometer operatively coupled to a computer database over a network claim 1 , and is configured for acquisition of in vitro samples of human-tissue data claim 1 , and transfer of the human-tissue data to the computer database over the ...

ADAPTIVE LANE DETECTION SYSTEMS AND METHODS

Systems and methods for automatically identifying and characterizing one or more lanes in image data for one or more electrophoresed samples. The method includes receiving data representing an image of one or more electrophoresed samples, segmenting the data into one or multiple data segments or portions within a region of interest (ROI), wherein the one or multiple data segments represent (e.g., when visually displayed) one or multiple lane segments along a first axis in the ROI, each of the one or multiple lane segments traversing one or multiple lanes in the image data, generating an intensity profile for at least a first data segment of the one or multiple data segments along a second axis orthogonal to the first axis, and processing the intensity profile to determine a location and parameters for each of one or multiple lanes in the first data segment. 1. A computer-implemented method of automatically identifying and characterizing one or more lanes in image data for one or more electrophoresed samples , the method comprising:receiving data representing an image of one or more lanes of electrophoresed samples;segmenting the image into one or multiple data segments within a region of interest (ROI), along a first axis in the ROI, each of the one or multiple data segments traversing one or multiple lanes of the one or more lanes;generating an intensity profile for at least a first data segment of the one or multiple data segments along a second axis orthogonal to the first axis in the ROI;processing the intensity profile to determine a location and parameters for each of the one or multiple lanes represented in the first data segment; andoutputting the determined locations and parameters of the one or multiple lanes represented in the first data segment.2. The method of claim 1 , further including receiving a selection of the ROI claim 1 , the ROI including data representing the one or multiple lanes.3. The method of claim 2 , wherein the selection of the ROI ...

SAMPLE INSPECTION PLAN MANAGEMENT DEVICE, SAMPLE INSPECTION PLAN MANAGEMENT SYSTEM, SAMPLE INSPECTION PLAN MANAGEMENT METHOD, AND PROGRAM

Provided are a sample inspection plan management device, a sample inspection plan management system, a sample inspection plan management method, and a program capable of managing a sample inspection implemented by a doctor as a starting point. There is provided a sample inspection plan management device () that manages a sample inspection plan in a case where a sample inspection is implemented by using a sample inspection kit acquirable by a medical examinee outside a hospital. The device includes an inspection plan acquisition unit (A) that acquires a sample inspection plan created by a doctor via a system of the hospital, a delivery information output unit (A) that outputs delivery information including a delivery destination of the sample inspection kit based on the sample inspection plan, and an inspection result acquisition unit (B) that acquires an inspection result of a sample collected by using the sample inspection kit delivered based on the delivery information via a system of an inspection institution that implements the sample inspection by retrieving the sample inspection kit. 1. A sample inspection plan management device that manages a sample inspection plan in a case where a sample inspection is implemented by using a sample inspection kit acquirable by a medical examinee outside a hospital , the device comprising:an inspection plan acquisition unit that acquires a sample inspection plan created by a doctor via a system of the hospital;a delivery information output unit that outputs delivery information including a delivery destination of the sample inspection kit based on the sample inspection plan; andan inspection result acquisition unit that acquires an inspection result of a sample collected by using the sample inspection kit delivered based on the delivery information via a system of an inspection institution that implements the sample inspection by retrieving the sample inspection kit.2. The sample inspection plan management device according to ...

BIOLOGICAL FLUID ANALYSIS AND PERSONALIZED HYDRATION ASSESSMENT SYSTEMS

A method of measuring an analyte in a bodily fluid sample and combining measurement data from multiple users may involve initiating a wireless connection between a handheld analyzer and a smart computing device on which an analyte analysis application has been downloaded and inserting a test strip into the handheld analyzer. The method may further involve collecting a sample of a bodily fluid on the test strip, measuring, with the handheld analyzer, a concentration of at least one analyte in the sample, wirelessly communicating the measured concentration from the handheld analyzer to the smart computing device, and displaying the measured concentration on the smart computing device. Finally, the method may involve transmitting the measured concentration to a database and organizing data including the measured concentration and at least one additional measured analyte concentration from at least one additional user on the database. 1. A method of measuring an analyte in a bodily fluid sample and combining measurement data from multiple users , the method comprising:initiating a wireless connection between a handheld analyzer and a smart computing device on which an analyte analysis application has been downloaded;inserting a test strip into the handheld analyzer;collecting a sample of a bodily fluid on the test strip;measuring, with the handheld analyzer, a concentration of at least one analyte in the sample;wirelessly communicating the measured concentration from the handheld analyzer to the smart computing device;displaying the measured concentration on the smart computing device;transmitting the measured concentration to a database; andorganizing data including the measured concentration and at least one additional measured analyte concentration from at least one additional user on the database.2. The method of claim 1 , further comprising initiating a wireless connection between the smart computing device and the Internet claim 1 , wherein the database is located ...

Method and system for personalized, molecular based health management and digital consultation and treatment

The present disclosure relates to personalized health, specifically molecular based health management and digital consultation. In particular, the present disclosure is directed to methods and systems for assessing the health status of an individual based on correlations between multi-omics measures (e.g., genomics, metabolomics, exposomics and proteomics) and diseases or health risks as disclosed in published research data. The disclosure also relates to methods and systems for customized counseling to individuals regarding health status and actionable measures to improve their health status.

CONTENT MANAGEMENT SYSTEM FOR CREATION OF LIVING LAB REPORTS

The present disclosure provides a method for analyzing and providing insight and advice on genetic test results in the form of Living Lab Reports (LLRs). LLRs can be created within a web-based content management system (CMS) through a Data Definition Model (DDM). The DDM can determine the hierarchical order and structure of the LLR. The DDM can link the LLRs created within the CMS to users' genetic testing lab reports within a direct web portal. These LLRs can then be viewed by end users using a direct web portal. 1. A computer program product comprising a non-transitory computer-readable medium having computer-executable code encoded therein , the computer-executable code adapted to be executed to implement a method comprising: I) an information input module;', 'II) a report assignment module;', 'III) a review module;', 'IV) an output module; and', 'V) a report update module;, 'a) providing a content management system, wherein the content management system comprisesb) receiving, by the information input module, information obtained from a genetic analysis of a biological sample from a subject;c) performing an assignment analysis, by the report assignment module, of the information obtained from the genetic analysis;d) generating, by the report assignment module, a tentative assignment of a report to the subject based on the assignment analysis, wherein the report comprises an informational text that pertains to the information obtained from the genetic analysis;e) storing, by the review module, the tentative assignment, wherein the tentative assignment remains stored until the tentative assignment is reviewed and approved by an administrator;f) generating by the review module, based on receipt of approval by the administrator, an assigned report comprising the informational text;g) transmitting the assigned report from the review module to the output module;h) displaying by the output module the assigned report to a user;i) updating, by the report update module, ...

Machine Learning Systems and Methods for Predicting Risk of Renal Function Decline

Systems, methods and apparatuses are described herein that employ machine learning techniques to assess a likelihood or risk that one or more patients will experience an adverse outcome, such as a decline in renal function, within one or more timeframes. The embodiments may utilize patient data relating to demographics, vital signs, diagnoses, procedures, diagnostic tests, biomarker assays, genetic tests, behaviors, and/or patient symptoms, to determine risk information, such as important predictive features and patient risk scores. And the embodiments may automatically execute patient workflows, such as providing treatment recommendations to providers and/or patients, based on determined risk scores. 1. A computer-implemented method of determining a risk of renal function decline for a patient comprising: [ a demographic relating to an age of the patient; and', 'a demographic relating to a gender of the patient;, 'a plurality of demographics associated with the patient comprising, tumor necrosis factor receptor-1 (“TNFR1”);', 'tumor necrosis factor receptor-2 (“TNFR2”); and', 'kidney injury molecule-1 (“KIM1”);, 'wherein the plurality of lab tests comprises a first lab test associated with a first lab test variable relating to one of, 'a plurality of lab tests associated with the patient, each lab test of the plurality of lab tests associated with lab test information comprising a lab test variable and a lab test value relating to the variable,'}], 'analyzing, by a computer, input data received from one or more data sources to determine patient information associated with a patient, the patient information comprising a plurality of demographic features, each demographic feature of the plurality of demographic features relating to at least one demographic of the plurality of demographics; and', 'a plurality of lab test features, each lab test feature of the plurality of lab test features relating to at least one lab test of the plurality of lab tests;, 'calculating, ...

METHOD FOR ASSISTING IN DIAGNOSIS OF THREE MAJOR NEURODEGENERATIVE DISEASES

The method for assisting diagnosis of three major neurodegenerative diseases consisting of Alzheimer's disease, Parkinson's disease, and ALS provided by the present invention includes: 1. A method for assisting diagnosis of the three major neurodegenerative diseases consisting of Alzheimer's disease , Parkinson's disease , and amyotrophic lateral sclerosis (ALS) , comprising:obtaining a mass spectrum of a specimen collected from a subject by matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI/TOF-MS), andjudging the subject to be positive or negative with respect to the three major neurodegenerative diseases on the basis of the magnitude of peak values at a mass-to-charge ratio (m/z) of the resulting mass spectrum of m/z=1733±1 and m/z=2399±1 or a prescribed peak information value derived from the peak values.2. The diagnostic assistance method according to claim 1 , wherein peak values at m/z=1733±1 and m/z=2399±1 of the resulting spectrum claim 1 , or prescribed peak information values derived from the peak values claim 1 , are respectively compared with preliminary prepared corresponding reference values for m/z=1733±1 and m/z=2399±1 claim 1 , andin the case where the peak value of m/z=1733±1, or a prescribed peak information value derived from the peak value, exceeds the reference value for m/z=1733±1, and the peak value of m/z=2399±1, or a prescribed peak information value derived from the peak value, exceeds the reference value for m/z=2399±1, the subject is judged to be positive for the three major neurodegenerative diseases.3. The diagnostic assistance method according to claim 1 , wherein the specimen collected from the subject is cerebrospinal fluid.4. The diagnostic assistance method according to claim 2 , wherein the specimen collected from the subject is cerebrospinal fluid. The present application claims priority on the basis of Japanese Patent Application No. 2018-123452 filed on Jun. 28, 2018, the content of which is ...

APPARATUSES AND METHODS FOR DETERMINING A PATIENT'S RESPONSE TO MULTIPLE CANCER DRUGS

Apparatuses (including devices and systems) and methods for determining if a patient will respond to a variety of cancer drugs. 1107.-. (canceled)108. A method of estimating a patient's response to a plurality of cancer drugs or therapies using a marker processing apparatus , the method comprising:entering a plurality of patient-specific marker values into the marker processing apparatus, wherein the plurality of patient-specific maker values were identified by testing a patient sample for a plurality of markers to identify the patient-specific marker values;using the marker processing apparatus to determine an equivalence level for at least some of the patient-specific marker values relative to reference marker values in a library of reference marker values by applying set of equivalence rules, followed by setting the equivalence level, wherein the equivalence level includes: high equivalence, medium equivalence, low equivalence or no equivalence;using the marker processing apparatus to determine patient-specific marker values that are likely benign from those having no equivalence to a reference marker value by applying structural rules to the patient specific marker values having no equivalence to the reference marker value to identify a structural defect in a marker referenced by the patient specific marker value;using the marker processing apparatus to automatically prioritize patient-specific marker values having equivalence to the reference marker, wherein the equivalence is high equivalence, medium equivalence or low equivalence;identifying drugs or therapies related to markers corresponding to patient-specific marker values having equivalence to a reference marker value; andoutputting an estimated response to the identified drug or therapy based on the determined equivalence level patient-specific marker values.1091. The method of claim , wherein using the marker processing apparatus to determine an equivalence level comprises comparing the at least some of ...

Management of multiple devices within an analyte monitoring environment

Systems, devices, and methods are provided for the management of multiple sensor control devices and/or multiple reader devices in an in vivo analyte monitoring environment, and also for resolving conflicts when merging data collected by different reader devices.

DIAGNOSIS OF DISEASE USING LASER-INDUCED BREAKDOWN SPECTROSCOPY AND MACHINE LEARNING

Diagnosing a pathology using LIBS and biological fluids includes focusing light on to a sample on a substrate to cause ablation of the sample and formation of a plasma, collecting optical emission from the plasma, and providing the optical emission to a spectroscopic acquisition component that provides information on spectral data of the plasma. The spectral data is provided to a machine learning algorithm to diagnose a pathology in the sample, where the algorithm is trained on a training set that includes spectral features in a difference spectrum derived from differences between a first LIBS optical emission spectrum collected from one or more samples of the biological fluid that have the pathology or known progress of the pathology and a second LIBS optical emission spectrum collected from one or more samples of the predetermined biological fluid that do not have the pathology or the known progress of the pathology. 1. A method for screening patients with , diagnosing , or monitoring progress of a pathology using laser induced breakdown spectroscopy (LIBS) and biological fluids , the method comprising:depositing a sample of a predetermined biological fluid on a predetermined substrate;focusing light from a laser light source on the sample deposited on the predetermined substrate, wherein an energy and pulse length of the laser light source are configured to cause ablation of the sample and formation of a plasma;collecting optical emission from the plasma;providing collected optical emission to a spectroscopic acquisition component, wherein the spectroscopic acquisition component provides information on spectral data of the plasma;providing the spectral data from the collected optical emission to a processing component, wherein the processing component includes one or more processors; andusing a machine learning algorithm and the one or more processors to screen a patient with, diagnose, or monitor progress of the pathology in the sample, wherein the machine ...

DIGITAL PASS VERIFICATION SYSTEMS AND METHODS

Digital pass verification systems and methods are disclosed herein. An apparatus disclosed herein includes memory including instructions that, when executed, cause processor circuitry to: access a result of a diagnostic test associated with a test kit identification; associate the result of the diagnostic test with a user identification; and transmit the result of the diagnostic test and the test kit identification to a first device to cause the first device to generate a machine-readable pass on a display of the first device. 1. (canceled)2. A digital pass management system comprising:memory including information of a plurality of users, the information including a plurality of results of diagnostic tests for analytes of interest and a plurality of user identifications; access a result of a diagnostic test for an analyte of interest of the plurality of results of diagnostic tests;', 'associate the result of the diagnostic test with a user identification of the plurality of user identifications; and', 'transmit the result of the diagnostic test to a user device; and, 'first processor circuitry to execute first instructions to determine a time of the diagnostic test;', 'generate a machine-readable pass based on the result of the diagnostic test and the time of the diagnostic test, the machine-readable pass indicative of a negative result for the diagnostic test for the analyte of interest; and', 'display the machine-readable pass on a display of the user device., 'second instructions stored in the user device, the second instructions to be executed by second processor circuitry of the user device to3. The digital pass management system of claim 2 , wherein the analyte of interest is an infectious disease.4. The digital pass management system of claim 3 , wherein the analyte of interest is a coronavirus.5. The digital pass management system of claim 3 , wherein the analyte of interest is a COVID-19 antibody.6. The digital pass management system of claim 2 , wherein ...

Inferring a condition of a medical analyzer

A computer-implemented method for inferring a condition of at least one analytical device based on at least one automatic notification received over a network from the analytical device is disclosed. The method comprises receiving, at a data processing agent, at least one automatic notification from at least one analytical device, processing, at the data processing agent, the at least one automatic notification, to thus identify one or more characteristics of the at least one automatic notification from the at least one analytical device, inferring, at the data processing agent, the condition of the at least one analytical device, by applying the one or more identified characteristics to a model; and generating, at the data processing agent, a notification reporting the inferred condition of the analytical device.

CONTINUOUS BIOMETRIC INFORMATION MEASURING DEVICE USING SENSOR USAGE INFORMATION STORED IN MEMORY

The present invention relates to a method of managing biometric information and, more particularly, a method of managing biometric information being capable of preventing the use of a sensor module of which an expiration date has expired, or a defective sensor module by determining the validity of a sensor module of a continuous biometric information measuring device on the basis of the generation date of sensor usage information or production lot information received from the continuous biometric information measuring device and preventing a reuse or a shared use of the sensor module on the basis of user information provided in a measurement message received from the continuous biometric information measurement device. 1. A continuous biometric information measuring device comprising:a sensor module positioned on a user's skin and periodically measure user's biological information from the body fluid; anda transmitter connected to the sensor module in a detachable manner to transmit the biometric information measured by the sensor module to a user terminal,wherein the sensor module includes a separate memory storing sensor usage information therein.2. The continuous biometric information measuring device according to claim 1 , wherein the sensor usage information includes registered sensor usage information previously registered in the memory claim 1 , generated sensor usage information generated when the sensor module and the transmitter are connected claim 1 , and received sensor usage information received from the user terminal through the transmitter.3. The continuous biometric information measuring device according to claim 2 , wherein the registered sensor usage information is at least one of an identifier claim 2 , a manufacturing date claim 2 , and a production lot of the sensor module claim 2 ,the generated sensor usage information is at least one of a use-start time of the sensor module and an identifier of the transmitter, andthe receiving sensor usage ...

System for collecting and utilizing health data

A system for collecting and utilizing health data can include collecting data relative to a patient's health and aggregating the data with other sources of data to define a database. The patient data can be collected using an electronic device, such as a smart contact lens or smart contact lens container. The data within the database can be manipulated, organized, or otherwise processed to determine trends, relationships, and other characteristics of the database. The characteristics of the database can be correlated to predict a health condition of the patient, generate a healthcare recommendation, or a combination thereof.

BLOOD TEST SUPPORT DEVICE, BLOOD TEST SUPPORT SYSTEM, BLOOD TEST SUPPORT METHOD, AND PROGRAM

Provided are a blood test support device, a blood test support system, a blood test support method, and a program that can reduce a burden on a medical examinee and obtain highly accurate test results. The blood test support device includes an information acquisition unit that acquires an order for a blood test kit from a medical examinee; a storage unit that stores the medical examinee and an identification number given to the blood test kit in association with each other; a processing unit that calculates a recommended date and time at which blood collection is performed using the blood test kit to which the identification number is given; and an information output unit that outputs the identification number of the blood test kit and the recommended date and time in placing the order from the medical examinee. 1. A blood test support device comprising:a storage configured to store an identification number given to a blood test kit; andat least one processor configured to:acquire an order for a blood test kit from a medical examinee;store an identification number given to the blood test kit in the storage in association with the medical examinee;calculate a recommended date and time at which blood collection is performed using the blood test kit to which the identification number is given; andoutput the identification number of the blood test kit and the recommended date and time in placing the order from the medical examinee.2. The blood test support device according to claim 1 ,wherein the at least one processor calculates the recommended date and time except a case where a blood-collection performance date or delivery period is at least one of Saturday, Sunday, a national holiday, a long holiday season, or year-end and New Year holidays.3. The blood test support device according to claim 1 ,wherein the at least one processor calculates the recommended date and time on the basis of at least one of a season, an outside temperature of an area, or a presence or ...

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Clinical decision support (cds) for radiotherapy in prostate cancer

A system ( 30 ) and method for detecting or predicting toxicity induced by radiation therapy. A device ( 34 ) is configured for determining polypeptide biomarkers present in a urine sample. At least one processor ( 36 ) is programmed to detect or predict radiation toxicity based on one or more polypeptide biomarkers determined to be in the urine sample.

METHOD OF DETECTING SEPSIS USING VITAL SIGNS, INCLUDING SYSTOLIC BLOOD PRESSURE, HEMATOLOGY PARAMETERS, AND COMBINATIONS THEREOF

Using vital sign measurements, such as systolic blood pressure (SBP), when combined with hematology parameters such as White Blood Cell Count (WBC) and Monocyte Distribution Width (MDW), has been identified as an improved method for detecting sepsis. The probability of having or developing sepsis is determined when each measurement is compared to a predetermined criteria and the combination of measurements that are within a reference range determines this probability. 1. A method of assessing a probability that a patient will develop sepsis comprising:a. obtaining a set of patient measurements comprising white blood cell count (WBC), monocyte distribution width (MDW), and one or more vital signs;b. detecting a sepsis predictive combination in the set of patient measurements by comparing at least one of the one or more vital signs and one or more hematology parameters from the set of patient measurements with respective predetermined criteria; andc. providing the probability that the patient will develop sepsis when the sepsis predictive combination is detected in the set of patient measurements.2. The method of claim 1 , wherein the at least one of the one or more vital signs is blood pressure.3. The method of claim 2 , wherein the blood pressure is systolic blood pressure (SBP).4. The method of claim 3 , wherein the predetermined criteria for SBP is a value of or below about 100 mmHg.5. The method of claim 1 , whereina. at least one measurement from the set of patient measurements is inputted from an electronic medical record; andb. at least one measurement from the set of patient measurements is inputted from an analyzer.6. The method of claim 1 , wherein:a. the one or more hematology parameters comprises MDW; andb. the predetermined criteria for MDW is a value above 20.0 channels.7. The method of claim 1 , whereina. the one or more hematology parameters comprises WBC; and{'sup': 3', '3, 'b. the predetermined criteria for WBC is a value less than about 4.0×10/μL, ...

Measuring Apparatus, Computer Readable Medium Storing Measuring Program and Measuring Method

A measuring apparatus includes: a measuring unit to measure a signal value corresponding to a concentration of a specified substance contained in a first sample; an acquiring unit to acquire a reference value pertaining to the specified substance contained in a second sample; a calculation unit to calculate a concentration value of the specified substance contained in the first sample, based on the signal value and the reference value; a determination unit to determine whether a variation in the concentration value of the specified substance contained in the first sample is equal to or less than a threshold value; and an output unit to output, to a display unit, recommendation information representing recommendation for acquiring the reference value when the variation in the concentration value of the specified substance contained in the first sample is equal to or less than the threshold value. 1. A measuring apparatus comprising:a measuring unit configured to measure a signal value corresponding to a concentration of a specified substance contained in a first sample;an acquiring unit configured to acquire a reference value pertaining to the specified substance contained in a second sample;a calculation unit configured to calculate a concentration value of the specified substance contained in the first sample, based on the signal value and the reference value;a determination unit configured to determine whether a variation in the concentration value of the specified substance contained in the first sample is equal to or less than a threshold value; andan output unit configured to output, to a display unit, recommendation information representing recommendation for acquiring the reference value when the variation in the concentration value of the specified substance contained in the first sample is equal to or less than the threshold value.2. The measuring apparatus according to claim 1 , wherein the concentration value of the specified substance contained in the ...

WEARABLE DIGITAL DEVICE FOR PERSONAL HEALTH USE FOR SALIVA, URINE, AND BLOOD TESTING AND MOBILE WRIST WATCH POWERED BY USER BODY

Provided are a wearable personal digital device and related methods. The wearable personal digital device may comprise a processor, a display, biometric sensors, activity tracking sensors, a memory unit, a communication circuit, a housing, an input unit, a projector, a timepiece unit, a haptic touch control actuator, and a band. The processor may be operable to receive data from an external device, provide a notification to a user based on the data, receive a user input, and perform a command selected based on the user input. The communication circuit may be communicatively coupled to the processor and operable to connect to a wireless network and communicate with the external device. The housing may be adapted to enclose the components of the wearable personal digital device. The band may be adapted to attach to the housing and secure the wearable personal digital device on a user body. 1. An Artificial Intelligence (AI) wearable digital device for personal health use for saliva , urine , and blood testing , the device comprising: receive data from an external device;', 'based on the data, provide a notification to a user;', 'receive a user input;', 'perform a command, the command being selected based on the user input;', 'provide a natural language user interface to communicate with the user, the natural language user interface being operable to sense a user voice and provide a response in a natural language to the user;, 'a processor being operable toa near field communication (NFC) unit communicatively coupled to the processor;a display communicatively coupled to the processor, the display including a touchscreen, wherein the display includes a force sensor, wherein the force sensor is operable to sense a touch force applied by the user to the display and calculate coordinates of a touch by the user, and further operable to analyze the touch force, and based on the touch force, select a tap command or a press command based on a predetermined criteria;a memory ...

Systems and methods for display device and sensor electronics unit communication

Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

Information provision method, information processing system, information terminal, and information processing method

In order to objectively grasp a stress state of a user and to prevent postpartum depression, biological gas information is acquired via a network, where the biological gas information indicates a concentration of phenol of the user and is obtained by a sensor that detects phenol released from a skin surface of the user. From a memory storing information including an upper limit of a normal range of the concentration of phenol per unit period, the information indicating the upper limit of the normal range is read out. When a frequency in the unit period with which the concentration of phenol of the user exceeds the upper limit of the normal range is determined to have an increasing tendency based on the biological gas information obtained during a pregnancy period of the user, the information related to stress of the user is output to an information terminal of the user.

Medical information processing apparatus

A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain, from among medical data related to subjects, medical data in a specific time period at or earlier than a previous point in time that is earlier by a predetermined length of time than a time of occurrence of a predetermined state change in the subjects. The processing circuitry is further configured to generate, on the basis of information about the medical data in the specific time period, learning-purpose data used for generating a learned model configured to output information about the predetermined state change in a subject being subject to a prediction that may occur at a time later by the predetermined length of time than a time at which a medical service is provided for the subject.

METHOD FOR IDENTIFICATION OF CANCER PATIENTS WITH DURABLE BENEFIT FROM IMMUNOTEHRAPY IN OVERALL POOR PROGNOSIS SUBGROUPS

A blood-based sample from a cancer patient is subject to mass spectrometry and the resulting mass spectral data is classified with the aid of a computer to see if the patient is a member of a class of patients having a poor prognosis. If so, the mass spectral data is further classified with the aid of the computer by a second classifier which identifies whether the patient is nevertheless likely to obtain durable benefit from immunotherapy drugs, e.g., immune checkpoint inhibitors, anti-CTLA4 drugs, and high dose interleukin-2. 1. A method of detecting a class label in a lung cancer patient , a renal cell carcinoma patient , or a melanoma patient comprising:(a) conducting a mass spectrometer test on a blood-based sample of the cancer patient to obtain a mass spectrum; obtaining integrated intensity values of selected features in the mass spectrum at one or more m/z ranges from a multitude of mass-spectral features listed in Table 25; using the integrated intensity values in a first stage classification algorithm using a training set comprising class-labeled spectra produced from blood-based samples from the same type of cancer patients to identify the patient as being in a class of patients determined to be a poor prognosis subgroup, and(b) identifying the cancer patient as being in the class of patients determined to be a poor prognosis subgroup, and operating on the mass spectral data with a programmed computer implementing a second stage classification algorithm; wherein in the operating step the classifier compares the integrated intensity values with feature values of a reference set of class-labeled mass spectral data obtained from blood-based samples from a multitude of patients having the same type of cancer treated with an immunotherapy drug and detecting a class label for the sample.2. The method of claim 1 , wherein the immunotherapy drug comprises an antibody drug blocking ligand activation of the PD-1 checkpoint protein claim 1 , anti-CTLA4 drugs claim ...

MEDICAL SUPPORT SYSTEM, MEDICAL SUPPORT DEVICE, AND MEDICAL SUPPORT METHOD

A medical support system () according to an embodiment includes: a scanner () configured to scan an evaluation piece into which a specimen is processed and acquire an evaluation piece image; a server () configured to compare specimen information on the specimen and evaluation piece information that is obtained from the evaluation piece image and output a comparison result; and a display device () configured to present the comparison result to a user is provided. This makes it possible to reduce work of an operator. 1. A medical support system comprising:a scanner configured to scan an evaluation piece into which a specimen is processed and acquire an evaluation piece image;a server configured to compare specimen information on the specimen and evaluation piece information that is obtained from the evaluation piece image and output a comparison result; anda display device configured to present the comparison result to a user.2. The medical support system according to claim 1 , wherein the specimen information contains information on processing of the specimen into the evaluation piece.3. The medical support system according to claim 2 , wherein the information on the processing contains information on at least any one of a block piece obtained by cutting a block out of the specimen claim 2 , an embedded piece in which the block piece is embedded claim 2 , a slice piece obtained by slicing the embedded piece claim 2 , and a stained piece obtained by staining the slice.4. The medical support system according to claim 3 , whereinthe specimen information contains a specimen identifying character string that identifies the specimen,the scanner is configured to capture an image of an evaluation piece identifying character string that is assigned to the evaluation piece and the whole evaluation piece, andthe server is configured to compare the specimen and the evaluation piece with the specimen identifying character string and the evaluation piece identifying character ...

METHODS FOR ASSESSING THE PROBABILITY OF ACHIEVING ONGOING PREGNANCY AND INFORMING TREATMENT THEREFROM

The invention provides methods for analyzing a patient's potential for achieving ongoing pregnancy with respect to a specific fertility treatment. These methods involve conducting one or more tests on the patient to determine a body mass index (BMI) of the patient and obtaining one or more clinical characteristics from the patient. In one aspect, at least one of the clinical characteristics is age, clinical diagnosis, weight, basal antral follicle count, or current medications. The methods further involve comparing the obtained clinical characteristics to a reference set of data obtained from a female reference population for which results of fertility treatments are known, at least some of the reference population having used ovulation induction agents. Based on the results of the comparing step, the patient is then informed of her potential for achieving ongoing pregnancy with respect to the specific fertility treatment. 130-. (canceled)31. A method for analyzing a patient's potential for achieving ongoing pregnancy with respect to a specific fertility treatment comprising:a) measuring a plurality of clinical characteristics in a patient, the characteristics selected from the group consisting of: age, weight, basal antral follicle count (BAFC), and current medications;b) determining body mass index (BMI) of said patient;c) comparing results obtained from said measuring and determining steps to reference data comprising BMI and at least one of: age, weight, BAFC, and medications taken, said reference data being obtained from female patients whose treatment and fertility outcome are known; andd) identifying a course of treatment for said specific fertility treatment for said patient based on a best fit between said clinical characteristics and said body mass index BMI of said patient and said reference data.32. The method of claim 31 , further comprising predicting a probability of achieving ongoing pregnancy using said course of treatment for said specific ...

Test Apparatus and Methods for ST2 Cardiac Biomarker

The technology described in this document can be embodied in a test strip for use in measuring a level of an ST2 cardiac biomarker in a blood plasma sample. The test strip includes a base, and a plurality of conjugates, wherein each conjugate includes a reporter group bound to a first antibody that binds to ST2. A conjugate pad disposed along a length of the base and is configured to hold the plurality of conjugates that bind with ST2 to produce conjugate-ST2 complexes. The conjugate pad is further configured to receive the blood plasma sample. The test strip also includes a plurality of second and third antibodies that bind to ST2, and the conjugate-ST2 complexes, respectively. The plurality of second antibodies are bound to a membrane in a test location and the plurality of third antibodies are bound to the membrane in a control location. 119.-. (canceled)20. A test system for ST2 cardiac biomarker , comprising:a test strip configured to facilitate detection of a threshold level of ST2 in blood plasma; a first section comprising an outer face and an inner face, wherein the inner face of the first section comprises a channel to receive the test strip along the length of the first section, and', a buffer port configured to allow a buffer solution to be dispensed to a portion of the test strip proximate to a first end of the test strip,', 'a test window configured to facilitate imaging of one or both of a test location and a control location on the test strip,', 'a sample port disposed between the buffer port and the test window, the sample port configured to enable a sample of blood plasma to be dispensed to the test strip, and', 'a set of projections disposed on the inner face of the second section between the test window and the sample port such that in the attached configuration, each projection in the set of projections is in contact with the test strip, wherein', 'a height of at least one projection in the set of projections is different from a height of ...

METHODS AND SYSTEMS FOR BIOMARKER ANALYSIS

Method and systems are described comprising receiving a plurality of human subject biomarker concentration values associated with a human subject, wherein the plurality of human subject biomarkers is associated with a condition, determining, based on the plurality of human subject biomarker concentration values, a human subject test statistic, comparing the human subject test statistic to a test statistic threshold, wherein the test statistic threshold is derived based on non-human primate (NHP) subject data, and, determining, based on the human subject test statistic exceeding the test statistic threshold, that the human subject has the condition. 1. A method comprising:receiving a plurality of human subject biomarker concentration values associated with a human subject, wherein the plurality of human subject biomarkers is associated with a condition;determining, based on the plurality of human subject biomarker concentration values, a human subject test statistic;comparing the human subject test statistic to a test statistic threshold, wherein the test statistic threshold is derived based in part on non-human primate (NHP) subject data; anddetermining, based on the human subject test statistic exceeding the test statistic threshold, that the human subject has the condition.2. The method of claim 1 , wherein receiving the plurality of subject biomarker concentration values comprises:measuring an intensity of light reflected from each of a plurality of zones of a lateral flow assay test strip, wherein each of the plurality of human subject biomarkers is associated with one zone of the plurality of zones, and wherein a control is associated with at least one zone of the plurality of zones; andconverting, for each zone of the plurality of zones, the intensity of light into a human subject concentration value for the biomarker of the plurality of human subject biomarkers associated with a respective zone of the plurality of zones.3. The method of claim 1 , wherein the ...

Intraoperative surgical event summary

Systems and methods for generating decision support data for surgical videos are disclosed, the system may include at least on processor configured to implement a method. The method may include receiving video footage of a surgical procedure performed by a surgeon on a patient in an operating room and implementing a model on the received video footage to determine an existence of a surgical decision-making junction. The model may be trained to detect decision-making junctions using training data based on historical video footage depicting surgical situations. The method may include accessing, in a data structure, a correlation between an outcome and a specific action taken at the decision-making junction, and, based on the existence of the decision-making junction and the correlation, outputting a recommendation to at least one of a user device or a user interface related to the specific action.

Systems and Methods for Real-Time Health Certification Using Point-of-Care Data

A health pass system for COVID-19 is provided. The system includes a database including information on a plurality of individuals. The database is configured to receive point-of-care data relating to the plurality of individuals, the point-of-care data including at least one medical test result for COVID-19 antibodies for at least one of the plurality of individuals. The system includes a processing device configured to analyze the point-of-care data and generate a report. The system includes means for transmitting the report to a mobile electronic device of at least one of the plurality of individuals. The system includes means for displaying the report with a user interface of the mobile electronic device in the form of a real-time health certification.

METHOD FOR DETERMINING FIBER INTAKE

The present invention relates to a method for controlling fiber intake in mammals, comprising the steps: a) providing at least one input data; b) based on said input data, generating at least one output data; wherein the input data is based on information selected from the group consisting of host DNA, host metabolism, host colonic microbial composition, gene activity, metabolic activity, host specific parameters, and any combinations thereof wherein the output data is selected from the group consisting of information on fiber consumption, fiber supplementation and, any combinations thereof. The present invention further relates to a system and use of said method. 1. A method for controlling fiber intake in mammals , comprising the steps:a) providing at least one input data; andb) based on said input data, generating at least one output data;wherein the input data is based on information selected from the group consisting of host DNA, host metabolism, host colonic microbial composition and/or gene activity and/or metabolic activity, host specific parameters and, any combinations thereof and wherein the output data is selected from the group consisting of information on fiber consumption, fiber supplementation and, any combinations thereof.2. Method according to claim 1 , wherein the input data further comprise input measurements claim 1 , wherein the input measurements comprise physiological reported measurements such as blood pressure claim 1 , triglycerides claim 1 , cholesterol claim 1 , white blood cell count claim 1 , vitamin count claim 1 , immunoglobulins claim 1 , breath hydrogen claim 1 , and/or breath methane claim 1 , optionally wherein the input data further comprise information on age claim 1 , gender claim 1 , body mass index claim 1 , physical activity claim 1 , stress claim 1 , sleep claim 1 , disease state claim 1 , diet status claim 1 , gut status claim 1 , life style habits and/or antibiotic use.3. (canceled)4. Method according to claim 1 , ...

DIAGNOSIS FOR VARIOUS DISEASES USING TUMOR MICROENVIRONMENT ACTIVE PROTEINS

Systems and methods for disease diagnosis through the detection of multiple biomarkers by receiving concentration values of biomarkers, building a training set using the samples of the biomarkers, and performing correlation calculations on the biomarker concentration values to diagnose the disease. 1. A computer-implemented method of creating an evaluative model that indicates a probability of a disease state in a patient under examination , the method comprising:a. receiving a first set of concentration values of a first biomarker from a first set of samples from patients with a not-disease diagnosis;b. receiving a second set of concentration values of the first biomarker from a second set of samples from patients with a disease diagnosis, wherein the first set and second set of samples comprise a training set of samples;c. completing a correlation computation for the first biomarker from the first set of concentration values combined with the concentration values of the first biomarker from the second set of concentration values, wherein said computation may be simple regression, neural networks, ROC curve area maximization, random forest methods, support vector machine or other industry standard methods; andd. performing steps (a) through (c) for a second biomarker wherein the second biomarker is functionally orthogonal to the first biomarker, and wherein the second biomarker is analyzed independently or in conjunction in a multi-dimensional space with the first biomarker to indicate the probability of a disease state.2. The computer implemented method of claim 1 , wherein the training set of samples includes at least one of blood samples claim 1 , urine samples claim 1 , and tissue samples.3. The computer-implemented method of claim 1 , wherein the training set of samples includes an equal number of disease samples and not-disease samples.4. The computer implemented method of claim 3 , wherein the disease being diagnosed isa. non-small cell lung cancer; orb. ...

SYSTEMS and METHODS for DETECTING INFECTIOUS DISEASES

Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained. 1. A system for detecting the presence of one or more of a plurality of markers indicative of an infectious disease in a small-volume clinical sample , comprising:a) a sample handling system;b) a detection station comprising an optical sensor;c) a fluidically isolated sample collection unit configured to retain a clinical sample;d) an assay station comprising at least a first, second, and third fluidically isolated assay unit, wherein the first unit comprises a first reagent comprising an antibody, the second unit comprises a second reagent comprising an oligonucleotide, and the third unit comprises a third reagent comprising a chromogen, dye, or other label; ande) a controller, wherein the controller comprises a local memory and is operatively coupled to the sample handling system and the detection station;wherein the system is configured to perform assays with any one or more of the first, second, and third assay units; wherein the local memory of the controller comprises a protocol comprising instructions for: i) directing the sample handling ...

Consumer-Oriented Biometrics Data Management and Analysis System for Personalized Analysis, Insights, and Predictive Blood Glucose Response

An embodiment may involve receiving a set of information including data points for health-related data for a user. The embodiment may also involve performing, by an analytics engine, tests between (i) a series of one or more blood sugar levels from the user measured at points in time, and (ii) data representing each of a normal blood sugar response, a pre-diabetic blood sugar response, and a diabetic blood sugar response. The embodiment may also involve based on the tests, making a conclusion, by the analytics engine, that the series of one or more blood sugar levels from the user indicates the normal blood sugar response, the pre-diabetic blood sugar response, or the diabetic blood sugar response. The embodiment may also involve adding an indication of the conclusion to a comprehensive health profile for the user. 1. A method comprising:receiving, by a server device, a set of information including pluralities of data points for health-related data for a user;in response to receiving the set of information, performing, by an analytics engine associated with the server device, tests between (i) a series of one or more blood sugar levels from the user, and (ii) data representing each of a normal blood sugar response, a pre-diabetic blood sugar response, and a diabetic blood sugar response, wherein the series of one or more blood sugar levels from the user is part of the health-related data for the user;based on the tests, making a conclusion, by the analytics engine, that the series of one or more blood sugar levels from the user indicates the normal blood sugar response, the pre-diabetic blood sugar response, or the diabetic blood sugar response;adding, by the server device, an indication of the conclusion to a comprehensive health profile for the user; andupon a request made on behalf of the user, providing, by the server device, at least part of the comprehensive health profile, including the conclusion.2. The method of claim 1 , wherein the series of one or more ...

REAGENTS FOR DETECTING ALU ELEMENTS IN CELL-FREE DNA (cfDNA)

Provided herein is the use of measurements of cell-free DNA, protein, and/or metabolite found in biofluid (e.g., urine) for identifying and treating organ injury. Provided herein are methods and compositions for monitoring, detecting, quantifying, and treating kidney injury in subjects suffering from or suspected of having an altered renal status by measuring amounts of cfDNA and one or more other markers, such as inflammation markers, apoptosis markers, protein, and DNA methylation. 1. A reaction mixture comprising:i) non-amplified cell-free DNA (cfDNA) extracted from a urine sample; andii) a nucleic acid probe having a 3′ end and a 5′ end, wherein the nucleic acid probe is complementary to at least 20 contiguous nucleotides of SEQ ID NO:1 and wherein the 3′ end and/or the 5′ end is covalently ligated to at least one detectable moiety.2. The reaction mixture of claim 1 , wherein the detectable moiety is a fluorescent molecule.3. The reaction mixture of claim 1 , wherein the detectable moiety is biotin.4. The reaction mixture of claim 3 , wherein the reaction mixture further comprises a streptavidin-linked signal-producing agent.5. The reaction mixture of claim 4 , wherein the streptavidin-linked signal-producing agent produces chemiluminescence claim 4 , color claim 4 , or fluorescence.6. The reaction mixture of claim 1 , wherein the detectable moiety is fluorescein or digoxigenin (DIG).7. The reaction mixture of claim 6 , wherein the fluorescein or digoxigenin (DIG) is conjugated to horseradish peroxidase (HRP).8. The reaction mixture of claim 1 , wherein the 3′ end or the 5′ end of the nucleic acid probe is covalently linked to at least two detectable moieties.9. The reaction mixture of claim 1 , wherein the 3′ and the 5′ ends of the nucleic acid probe are covalently linked to at least two detectable moiety.10. The reaction mixture of claim 1 , wherein the 3′ end or the 5′ end of the nucleic acid probe is covalently linked to at least three detectable moieties.11 ...

Methods for administering pexidartinib

The present disclosure relates generally to methods for using pexidartinib and related Risk Evaluation and Mitigation Strategy (REMS), while reducing the occurrence of hepatotoxic adverse events.

BIOLOGICAL SOUND MEASURING DEVICE, BIOLOGICAL SOUND MEASUREMENT SUPPORT METHOD, AND BIOLOGICAL SOUND MEASUREMENT SUPPORT PROGRAM

There is provided a biological sound measuring device that has a member which defines a space to be sealed by a body surface of a living body in a state of being pressed against the body surface, and that measures a biological sound of the living body based on pressure fluctuation in the space. The device includes: a sound generator that generates a sound toward the body surface; a sound measurer that measures a reflected sound of the sound generated by the sound generator; and a controller that determines whether or not a contact state or a contact position of the member with respect to the body surface satisfies a condition necessary for measurement of the biological sound, based on the reflected sound measured by the sound measurer, and that performs notification when it is determined that the condition is not satisfied. 1. A biological sound measuring device that has a member which defines a space to be sealed by a body surface of a living body in a state of being pressed against the body surface , and that measures a biological sound of the living body based on pressure fluctuation in the space , the device comprising:a sound generator that is disposed in the space of the member and that generates a sound toward the body surface;a sound measurer that is disposed in the space of the member and that measures a reflected sound of the sound generated by the sound generator; anda controller that determines whether or not a contact state or a contact position of the member with respect to the body surface satisfies a condition necessary for measurement of the biological sound, based on the reflected sound measured by the sound measurer, and that performs notification when it is determined that the condition is not satisfied.2. The biological sound measuring device according to claim 1 ,wherein when an intensity of the reflected sound measured by the sound measurer is lower than a threshold set in advance, the controller determines that the contact state does not ...

MANGANESE-BASED CHELATE CONJUGATES FOR MOLECULAR MR IMAGING

Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presence of biochemical targets. 3. The compound of claim 1 , wherein Q is CH.4. The compound of claim 1 , wherein Y is CH.5. The compound of claim 1 , wherein at least one Y is CZ claim 1 , wherein Z is selected from the group consisting of COR claim 1 , C-Calkyl claim 1 , and OR.6. The compound of claim 1 , wherein one Y is CZ claim 1 , wherein Z is selected from the group consisting of COR claim 1 , C-Calkyl claim 1 , and OR claim 1 , and all other Y are CH.7. The compound of claim 1 , wherein each Ris H or C-Calkyl claim 1 , wherein the alkyl is optionally substituted by 1 claim 1 , 2 claim 1 , 3 claim 1 , or 4 OH groups.8. The compound of claim 1 , wherein Rand Rare each H.919.-. (canceled)20. The compound of claim 1 , wherein Ris C-Ccycloalkylene.23. The compound of claim 1 , wherein Ris a C-Calkylene.24. (canceled)26. The compound of claim 1 , wherein Ris H.27. The compound of claim 1 , wherein Ris H.2948.-. (canceled)52. The compound of claim 49 , wherein for each Dand D claim 49 , Ris 1 claim 49 ,2-cyclohexylene claim 49 , Ris H claim 49 , Ris H claim 49 , DG is Formula II claim 49 , Q is CH claim 49 , the Y positioned α- to Q is C-(L)-TBM or C-(L)-TBM claim 49 , and all other Y are CH claim 49 , and Land Lare each —C(O)—.54. A method of magnetic resonance (MR) imaging a patient claim 49 , the method comprising:{'claim-ref': {'@idref': 'CLM-00049', 'claim 49'}, 'a) administering to the patient an effective amount of a compound of ; and'}b) acquiring an MR image of the patient.5559.-. (canceled)61. The compound of claim 49 , wherein Q is CH.62. The compound of claim 49 , wherein Y is CH.63. The compound of claim 49 , wherein at least one Y is CZ claim 49 , wherein Z is selected from the group consisting of COR ...

Blood glucose control system with automated backup therapy protocol generation

An automated blood glucose control system is configured to generate a backup therapy protocol comprising insulin therapy instructions derived from autonomously determined doses of insulin. The system generates a dose control signal using a control algorithm configured to autonomously determine doses of insulin to be infused into a subject for the purpose of controlling blood glucose of the subject based at least in part on a glucose level signal received from a glucose sensor. The system can track insulin therapy administered to the subject over a tracking period, including storing an indication of the autonomously determined doses of insulin delivered to the subject as basal insulin, as correction boluses of insulin, or as mealtime boluses of insulin. The system can generate a backup injection therapy protocol or a backup pump therapy protocol with insulin therapy instructions based at least in part on the insulin therapy administered to the subject over the tracking period.

BLOOD GLUCOSE CONTROL SYSTEM WITH CARBOHYDRATE THERAPY INDICATION

A blood glucose control system can generate an indication of total carbohydrate therapy over a period during use by a subject. The system can be connected to a medicament pump configured to deliver insulin therapy, other types of medicament therapy, or a combination of medicament therapies to the subject. The system can determine an amount of a counter-regulatory agent to respond to an impending risk of hypoglycemia or an episode of hypoglycemia and determine a dose of carbohydrate therapy based at least in part on the amount of the counter-regulatory agent. The system can track determined doses of carbohydrate therapy to generate the indication of total carbohydrate therapy over the period. 1. A computer-implemented method of generating an indication of total carbohydrate therapy over a period using a medicament pump configured to deliver at least insulin therapy to a subject , the method comprising: receiving a glucose level of the subject;', 'determining based at least in part on the glucose level that a triggering event for raising blood glucose level of the subject has occurred, wherein the triggering event indicates an impending risk of hypoglycemia is present in the subject or that an episode of hypoglycemia is present in the subject;', 'determining an amount of a counter-regulatory agent to respond to the impending risk of hypoglycemia or the episode of hypoglycemia;', 'determining a dose of carbohydrate therapy based at least in part on the amount of the counter-regulatory agent;', 'tracking, over a period comprising a plurality of hypoglycemia risk events or hypoglycemia episodes, determined doses of carbohydrate therapy to generate the indication of total carbohydrate therapy over the period; and', 'outputting the indication of total carbohydrate therapy., 'by a hardware processor configured to generate dose control signals for the medicament pump configured to deliver at least insulin therapy to the subject2. The computer-implemented method of claim 1 , ...

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Transportation management system, transportation management method, and program

A transportation management system according to an aspect is a transportation management system configured to manage transportation of a testing apparatus for diagnosing a health condition of a user by using a computer. A reservation for a test that a user undergoes is received, and a testing apparatus to be transported to the user is determined based on the reservation. The testing apparatus is transported to the user, and the user is diagnosed by using the testing apparatus.

Techniques for determining coagulation results

An automated method for determining a coagulation result of a biological sample is presented. The method includes obtaining a time series representing measurement data of a sample. The time series spans a period in which a clotting reaction is supposed to take place. The method includes obtaining a global model function configured to model measurement data of a sample in which a clotting reaction takes place. The global model function is configured to model the measurement data as a sigmoidal shape with at least one inflection point. The absolute value of the maximum curvature of the sigmoidal shape is larger on one side of the at least one inflection point than on the other side. The method includes fitting the model function to the time series representing measurement data to obtain a fitted model function and determining a coagulation result of the sample based on the fitted model function.

Pooled testing methods using compressed sensing for increasing the throughput and reliability of tests for the detection of defective units in a population

A method for pooled sample testing for a target substance using compressed sensing includes receiving a plurality of individual samples, determining a mixing matrix for a plurality of pooled sample mixtures to create by mixing portions of selected ones of the plurality of individual samples, and determining an allocation matrix for the plurality of pooled samples, wherein the allocation matrix allocations portions of each of the plurality of pooled samples for each test, performing mixing to create the plurality of pooled sample mixtures based on the mixing matrix and the allocation matrix, performing quantitative tests on the plurality of pooled sample mixtures so as to estimate an amount of the target substance contained within each of the plurality of pooled sample mixtures, and decoding results of the quantitative tests to determine quantitative estimates of amount of the target substance in each of the plurality of individual samples. 1. A method for pooled sample testing for a target substance using compressed sensing , the method comprising:receiving a plurality of individual samples;determining a mixing matrix for a plurality of pooled sample mixtures to create by mixing portions of selected ones of the plurality of individual samples;determining an allocation matrix for the plurality of pooled samples, wherein the allocation matrix allocations portions of each of the plurality of pooled samples for each test;performing mixing to create the plurality of pooled sample mixtures based on the mixing matrix and the allocation matrix;performing quantitative tests on the plurality of pooled sample mixtures so as to estimate an amount of the target substance contained within each of the plurality of pooled sample mixtures; anddecoding results of the quantitative tests on the plurality of the pooled sample mixtures using the mixing matrix and the allocation matrix to determine quantitative estimates of amount of the target substance in each of the plurality of ...

SYSTEM AND METHOD FOR ANALYZING AND PROVIDING PERSONALIZED COSMETIC INFORMATION

A system and method for providing personalized cosmetic information objectively and scientifically present personalized cosmetics suitable for an individual's skin type by a comparative analysis between genetic skin test result data, from which an individual's skin condition can be scientifically detected, and data obtained by a phenomenological self-skin examination and a skin condition measurement instrument. 1. A system for analyzing and providing personalized cosmetic information , comprising:{'b': '10', 'a genetic database () for processing percentage data on 28 genes related to skin, vitamin, obesity and hair loss genes received from a genetic analysis company;'}{'b': 300', '1', '100', '200, "a self-examination information input unit () for inputting, through Internet (I) or Wi-Fi (W), self-examination percentage data obtained by checking, at a user's PC () and a smartphone (), each of 33 questionnaire items in a skin and metabolism self-examination list and converted into percentages using the Likert scale of measurement;"}{'b': 410', '410', '400', '300', '410, 'a data storage unit (B) constituting a genetic analysis server () in a cloud server () for storing the genetic percentage data and self-examination information percentage data obtained by the self-examination information input unit () and an examination analysis processing unit (A) for a comparative analysis of the stored input data; and'}{'b': 420', '400', '2', '500, 'a data relay () in the cloud server () for inputting, through Wi-Fi (W), moisture and oil data and pigment, pore and wrinkle image data obtained by an IoT skin measurement terminal (),'}{'b': 420', '400', '100', '200', '1', '500', '500', '430', '400', '100', '200', '430', '430', '430', '410', '410', '10', '300', '430', '410', '300', '10', '430', '410', '100', '200, "wherein the skin measurement data is transmitted by the data relay () in the cloud server () to the user's PC () or smartphone () through Internet (I) or Wi-Fi (W) to ...

TEST RESULT AUTO VERIFICATION

An analyzer analyzes patient samples and the test results are then validated. The validation of test results may be performed either remotely over a network or at a local computer. For example, while network communication errors may prevent remote validation, the local validation could still be performed, which allows auto validation to be continuously performed. The validation of the test results of the patient sample obtained by the analyzer may further be performed by: 1) the first rule included in the first system of the laboratory; and 2) the second rule included in the second system accessible remotely via the network. The present disclosure further relates to an inspection management method based on at least one of the two rules. 1. A method implemented by a computing system including first and second systems for managing a test by a diagnostic analyzer , comprising:obtaining a test result of a sample from the diagnostic analyzer in a laboratory; andverifying the test result according to at least one of: 1) a first rule executable by the first system which is accessible from the laboratory via a network; or 2) a second rule executable by the second system deployed in the laboratory.2. The method according to claim 1 , further comprising:sending, to the first system, the test result which is to be verified by the first rule.3. The method according to claim 1 , further comprising:consolidating the verified test result on at least one of the first system or the second system.4. The method according to claim 1 , further comprising:allowing a user to access the verified test result from a web browser.5. The method according to claim 1 , further comprising:allowing a user to define the first rule via a web browser.6. The method according to claim 1 , further comprising:handling the order and the test result via the first system which is an interface between the diagnostic analyzer and a laboratory network.7. The method according to claim 1 , further comprising: ...

METHODS AND APPARATUS TO MONITOR LAB EQUIPMENT

An example system to monitor lab equipment includes: lab devices configured to perform sectioning, grinding, mounting, polishing, imaging, and/or hardness testing, of specimens; and an equipment monitoring system configured to: receive the data from the lab devices, the data comprising identifiers of the lab devices, operating statuses of the lab devices, current operating cycle information for the lab devices, error codes, and parameters of the operating cycles performed by the lab devices, wherein the lab devices are configured to transmit the data to the equipment monitoring system via a network; based on the error codes, output operator-readable information associated with the lab devices from which the error codes were received; and in response to at least one of the operating statuses, the current operating cycle information, the error codes, or the parameters satisfying an event definition, output an operator-readable notification identifying an operator action item based on the event definition. 1. A system to monitor lab equipment , the system comprising:a plurality of lab devices configured to perform at least one of sectioning, grinding, mounting, polishing, imaging, or hardness testing, of specimens; and receive the data from the lab devices, the data comprising identifiers of the lab devices, operating statuses of the lab devices, current operating cycle information for the lab devices, error codes, and parameters of the operating cycles performed by the lab devices, wherein the lab devices are configured to transmit the data to the equipment monitoring system via a network;', 'based on the error codes, output operator-readable information associated with the lab devices from which the error codes were received; and', 'in response to at least one of the operating statuses, the current operating cycle information, the error codes, or the parameters satisfying an event definition, output an operator-readable notification identifying an operator action ...

Automated prior authorization for genetic efficacy testing with presciption dispensation

System and methods for automating preauthorization of genetic efficacy testing with prescription dispensation are provided. Coverage requests for medicines are received from pharmacy systems. Databases are queried to retrieve policy rules for the coverage requests. A coverage decision analysis is performed and where an associated medication is otherwise approved for coverage and where genetic efficacy testing is available for the associated medication, a prior authorization for such genetic efficacy testing is automatically generated and included with which is transmitted together with an approval of coverage decision to a requesting one of said number of pharmacy systems.