Terpenoid heterodimer in Lancanang metasequoia and application of terpenoid heterodimer in preparation of acetyl-coenzyme A carboxylase inhibitor

The invention belongs to the technical field of medicines, and particularly relates to a triterpenoid-diterpenoid hybrid dimer (as shown in formulas 1, 2 and 3) which is separated from branches and leaves of a pinaceae (Pseudotsuga) plant (Pseudotsuga forresterii Craib) and has a novel structure, and application of the triterpenoid-diterpenoid hybrid dimer in preparation of an acetyl-coenzyme A carboxylase inhibitor. The structure of the triterpenoid-diterpenoid hybrid dimer is shown in formulas 1, 2 and 3. The compound is a natural hybrid dimer which is formed by carrying out Diels-Alder addition or Michael addition reaction on lanolin alkane type triterpenes with a unique spiro structure and abietane diterpenes. According to the present invention, the in vitro activity test results show that the compound has significant acetyl-coenzyme A carboxylase 1 (ACC1) inhibition activity, and can be used for preparing drugs for treating ACC1 mediated non-alcoholic steatohepatitis and other related ...

臭氧发生管

Micro-grid black-start method, device and system and storage medium

The invention provides a micro-grid black-start method, device and system and a storage medium, and the method comprises the steps: carrying out the prediction of a time-varying starting capability parameter of each distributed power supply at an (X + 1) th moment through a pre-trained BP neural network model, obtaining a black start evaluation index of each distributed power supply at the (X + 1) th moment by combining the start capability parameters which do not change along with time; updating a black-start evaluation matrix according to the black-start evaluation index of each distributed power supply at the (X + 1) th moment, evaluating the starting capability of each power supply through the black-start evaluation matrix, and updating a black-start strategy in real time according to the starting capability of each power supply; and performing black start according to the updated black start strategy. According to the method, the black start capability of each power supply can be continuously ...

Sesquiterpene-alkaloid heteropolymer and preparation method and pharmaceutical application thereof

The invention belongs to the technical field of medicines, and relates to a sesquiterpene-alkaloid heteropolymer with skeleton structures as shown in formulas 1-4, a preparation method of the sesquiterpene-alkaloid heteropolymer and application of the sesquiterpene-alkaloid heteropolymer in anti-leukemia medicines. The compound provided by the invention is extracted and separated from leaves and barks of Liriodendron chinense which is a medicinal plant of Magnoliaceae, and pharmacological experiments prove that the compound can significantly inhibit proliferation of four leukemia cells of Raji, Jeko-1, Daudi and Jurkat and induce apoptosis of cancer cells, can be independently applied or used together or combined with a suitable excipient, and can be used for preparing drugs for treating leukemia. The composition is prepared into oral or non-oral drug dosage forms for treatment or adjuvant treatment of leukemia according to a conventional method.

Server management method and device

The invention discloses a server management method and device, and the method comprises the steps: one physical machine deploys two servers, and the servers which are mutually main and standby servers are disposed on different physical machines. On one hand, two servers are deployed on one physical machine at the same time, and compared with a method that only one server is deployed on one physical machine, physical machine resources can be utilized to the maximum extent; and on the other hand, when one physical machine breaks down, the server on the physical machine cannot normally provide service, however, as the main server and the standby server are deployed on different physical machines in the method, when one server on the physical machine cannot work, the server cannot normally provide service. According to the scheme, the server can be started to replace the standby server on other physical machines, namely, the probability that the main server and the standby server fail at the ...

Method for repairing cracks of flow guide ring of inner sleeve of engine case

The invention provides a method for repairing cracks of a flow guide ring of an inner sleeve of an engine casing. The method comprises the following steps that S1, the flow guide ring to be repaired on the inner sleeve of the engine casing is removed; and S2, the position, except the to-be-repaired flow guide ring, of the inner sleeve of the cartridge receiver is welded through a vacuum brazing method to replace the flow guide ring. The method has the advantages that the repair cost and the repair quality are comprehensively considered, the damaged flow guide ring which is low in price and easy to replace is integrally cut off, and a new flow guide ring is welded again, so that the repair cost is very low, the repair difficulty is not high, and most importantly, the quality of the repaired casing inner sleeve can meet the drawing requirement; and the repair cost only accounts for 3% of the overall cost of the casing inner sleeve, so that the overall scrapping of the casing inner sleeve ...

Device and method for measuring high transmittance, reflectivity and non-uniformity of large-aperture flat plate element

The invention discloses a device and a method for measuring high transmittance, reflectivity and non-uniformity of a large-aperture flat plate element, belongs to measurement of large-aperture optical elements in the field of optical measurement, and aims to solve the technical problem of large measurement error of high transmittance, reflectivity and non-uniformity of the large-aperture flat plate element in the prior art. A coaxial mechanism for angle rotation of a large-diameter to-be-measured high-transmission mirror and position rotation of a first high-reflection transmission mirror is arranged, the first high-reflection transmission mirror is additionally arranged on one side of a to-be-measured sample, laser generated by a laser device forms detection light and reference light after passing through a spectroscope, the detection light enters the high-reflection mirror at a small angle, and the reference light enters the high-reflection mirror at a small angle. The detection light ...

Shaft pressure supplementing method for car shuttling elevator and computer readable storage medium

The invention relates to the technical field of shaft ventilation, in particular to a car shuttling elevator shaft pressure supplementing method and a computer readable storage medium. The method comprises the steps that elevator operation data and the internal and external pressure difference of a car in an elevator shaft on a corresponding floor are obtained; according to the elevator operation data, the time for a lift car to arrive at a target floor from the floor where the lift car is located is obtained; according to the time when the lift car reaches the target floor from the floor where the lift car is located, the starting time of a draught fan is obtained; and the fan parameters are regulated and controlled according to the starting time of the fan, so that the internal and external pressure difference of the elevator shaft tends to be balanced. The invention aims to provide a novel air pressure compensation control method, so that the pressure difference between the inside and ...

Gas recovery amount measuring method and system based on segmented integral calibration

The invention provides a gas recovery amount measuring method and system based on segmented integral calibration, and the method comprises the following steps: preparing an SF6 to-be-recovered gas tank with the initial pressure of P0, connecting the to-be-recovered gas tank with a gas inlet of a mass flowmeter, connecting a gas outlet of the mass flowmeter with a gas inlet of a recovery device, and connecting a gas outlet of the recovery device with a gas outlet of the gas recovery device; a gas outlet of the recovery device is connected with a recovery gas cylinder, and the weight of the recovery gas cylinder is weighed to be m0; starting the recycling device to recycle the SF6 gas; the calibration coefficient k1 of the pressure intensity of the gas tank in the sections from P0 to P1 is recovered; the calibration coefficient k2 of the pressure intensity of the gas tank in the sections from P1 to P2 is recovered; and the calibration coefficient of each segment is calculated in the same ...

Method for preparing ethylene-vinyl alcohol copolymer

The invention discloses a method for preparing EVOH (Ethylene Vinyl Alcohol), which comprises the following steps: (1) mixing ethylene, vinyl acetate, an initiator and a methyl acetate solvent, and carrying out polymerization reaction to obtain a mixed solution containing EVA (Ethylene Vinyl Acetate); and (2) mixing the EVA-containing mixed solution, a catalyst and an alcohol substance, and carrying out alcoholysis reaction to obtain an EVOH-containing mixed solution. According to the invention, methyl acetate is adopted as a solvent for polymerization reaction, and compared with methanol as the solvent for polymerization reaction, the chain transfer capacity of methyl acetate is lower than that of methanol, the molecular weight of an intermediate product EVA is higher, the molecular weight distribution of EVA is narrower, the molecular weight of EVOH is increased, and the strength and stability of EVOH are further significantly improved; compared with tert-butyl alcohol serving as a solvent ...

New energy unit power electronic energy interconnection converter and control method

The invention provides a new energy unit power electronic energy interconnection converter and a control method. The energy interconnection converter comprises a modular multi-level converter and a multi-port DC-DC converter. The modularized multi-level converter has n phases, the input structures of the phases are the same, and the multi-port DC-DC converter comprises three power modules and a three-winding high-frequency transformer; each phase of the modular multi-level converter is provided with N multi-port DC-DC converters, and the direct current sides of the power modules connected with the first winding and the second winding of the i-th multi-port DC-DC converter are connected with the direct current sides of the i-th power modules of the upper bridge arm and the lower bridge arm of the modular multi-level converter respectively. The topological structure has excellent expandability and reliability, the requirements for the performance of the new energy unit and the battery are ...

Stand-alone air combat decision-making method based on curriculum type reinforcement learning

The invention relates to a stand-alone air combat decision-making method based on curriculum-type reinforcement learning, and the method comprises the steps: building a dynamic model of a combat aircraft in a three-dimensional space, and selecting a state space vector of the combat aircraft; for a full-dimensional observation environment, an action network and an evaluation network are designed based on a full-connection neural network, and a gradient back propagation algorithm of the neural network is designed by using a PPO reinforcement learning algorithm. In order to solve the problem that a traditional reward function cannot break through human experience, a course type reward function module is established, an air combat strategy is gradually learned from easy to difficult, and the problem that learning is difficult under sparse reward information is solved. An intelligent agent experience playback mechanism is introduced in the air combat process, so that an intelligent agent is ...

Wind turbine generator variable inertia control method considering fan rotating speed and power grid frequency change

The invention discloses a wind turbine generator set variable inertia control method considering fan rotating speed and power grid frequency changes. When the frequency change rate of the power grid exceeds a threshold value, the fan is switched into variable inertia control, the comprehensive inertia of the fan is calculated by adopting a hyperbolic tangent function according to the frequency change and the rotating speed change, then an active power additional reference value is obtained and superposed on the active power reference value of the fan, and rapid control over active output is achieved. And when the active power output of the fan is smaller than the initial active power at the beginning of inertial support or the rotating speed change reaches a threshold value, switching to a rotating speed recovery stage. And when the active power output of the fan is equal to the maximum wind power, switching to maximum wind power tracking control, and recovering the active power output ...

Description text mining method and device, electronic equipment and storage medium

The invention discloses a discourse text mining method and device, electronic equipment and a storage medium. The method comprises the steps of obtaining a to-be-mined discourse text; inputting the to-be-mined argument text into a first mining network to obtain a semantic vector and a semantic implicit vector output by the first mining network; inputting the semantic vector and the semantic implicit vector into a second mining network to obtain an initial mining result corresponding to the to-be-mined argument text output by the second mining network; and correcting the initial mining result by utilizing the proxy probability distribution to obtain a final mining result. Wherein the final mining result represents the discussion component in the to-be-mined discussion text and the type of the discussion component and/or the discussion relationship and the type of the discussion relationship, and the proxy probability distribution is determined based on the prediction label corresponding ...

Method for sealing initiating explosive device electrode plug

The invention discloses a method for sealing an initiating explosive device electrode plug, which adopts a tunnel furnace for treatment and comprises the following steps: (1) selecting raw materials; (2) carrying out surface treatment on the sealing piece; (3) assembling a sealing piece; and (4) sealing the electrode plug to obtain the sealed electrode plug. Kovar alloy, molybdenum glass and a stainless steel cover body are used as raw materials, sealing piece surface treatment, sealing piece assembly and electrode plug sealing are conducted, a tunnel furnace is adopted for treatment, and the method has the advantages of being simple, efficient, low in energy consumption, low in cost, safe and capable of achieving continuous production.