30-05-2023 дата публикации
Номер: CN116178275A
Принадлежит:
The invention relates to a clobipram hydrobromide crystal form and a preparation method thereof, clobipram is used as a novel PDE4 inhibitor, at the early stage of drug research and development and at the very necessary stage of preparing a clobipram compound into a salt, the physical and chemical properties of the clobipram compound, such as solubility, crystallinity, hygroscopicity, melting point, solid stability and the like, can be improved. In view of the purpose, the crystal form of the clobipram hydrobromide is successfully synthesized through a drug salt sieve experiment, and compared with the clobipram, after the crystal form of the clobipram hydrobromide is salified, the crystallinity is not changed greatly, the polycrystal phenomenon of the salt is not found, the solubility is not obviously changed, the melting point is slightly increased, and the crystal form is not easy to absorb moisture; and a choice is provided for final salification of the medicine.
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