Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 3. Отображено 3.
09-07-2015 дата публикации

NOVEL AMIDE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLDUING SAME FOR PREVENTING AND TREATING PAIN

Номер: KR1020150080428A
Автор: PARK, HEA YOUNG, YUNE, TAE YOUNG, KAM, YOO LIM, CHOI, JIN SUNG
Принадлежит:

The present invention relates to: novel amide derivatives or pharmaceutically acceptable salts; a method for preparing the same; and a pharmaceutical composition including the same for preventing or treating pain. According to the present invention, the novel amide derivatives or pharmaceutically acceptable salts: inhibit activity of a sodium channel; has an effect of inhibiting pain caused by peripheral nerve damage, central nervous system damage, and inflammation as well; has an excellent effect of inhibiting MMP-2 and MMP-9 which are activated after spinal cord injury; and thus can be advantageously used for a pharmaceutical composition for preventing or treating neuropathic pain. COPYRIGHT KIPO 2015 (AA) Tail stimulus threshold value (g) (B1,B2) Tail stimulus latent period (s) (C1,C2,C3) Time after surgery (DD) Example 2 60 mg/kg (n = 4) (E1,E2,E3) Negative control group (n = 4) (FF) Example 2 60 mg/kg (n = 6) (GG) Example 2 60 mg/kg (n = 5) ...

Подробнее
Номер записи: 1
09-07-2015 дата публикации

NOVEL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PAIN, CONTAINING SAME

Номер: WO2015102390A1
Автор: PARK, Hey Young, YUNE, Tae Young, KAM, Yoo Lim, CHOI, Jin-Sung
Принадлежит:

The present invention relates to: a novel amide derivative or a pharmaceutically acceptable salt thereof; a preparation method therefor; and a pharmaceutical composition for preventing or treating pain, containing the same. The novel amide derivative or a pharmaceutically acceptable salt thereof, according to the present invention, has effects of inhibiting sodium channel activity and inhibiting pain caused by inflammation, peripheral nerve injuries and central nerve injuries, and has an excellent effect of inhibiting MMP-2 and MMP-9, which are activated after spinal injuries, and thus can be useful as a pharmaceutical composition for preventing or treating neuropathic pain.

Подробнее
Номер записи: 2
14-02-2017 дата публикации

신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물

Номер: KR0101705718B1
Автор: 박혜영, 윤태영, 감유림, 최진성
Принадлежит: 이화여자대학교 산학협력단

... 본 발명은 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물에 관한 것으로써, 본 발명에 따른 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염은 나트륨 채널 활성을 억제하고, 말초 신경 손상, 중추 신경 손상뿐만 아니라, 염증으로 유발된 통증을 억제하는 효과가 있으며, 척수 손상 후 활성화되는 MMP-2 및 MMP-9를 억제하는 효과가 우수하므로 신경병증성 통증 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.

Подробнее
Номер записи: 3