17-09-2015 дата публикации
Номер: WO2015137724A1
Автор:
KWON, Byoung Se,
KANG, Hyun-Guy,
KIM, Kwang-Hui,
KIM, Young-Woo,
KIM, Young-Ho,
PARK, Byung-Kiu,
PARK, Sang-Yoon,
PARK, Sang-Jae,
EOM, Hyeon-Seok,
OH, Ho-Sik,
YOO, Heon,
LEE, Don-Gil,
LEE, Seung-Hoon,
LEE, Young-Joo,
LEE, Jin-Soo,
CHOI, Beom-Kyu
Принадлежит:
The present invention relates to a method for isolating and proliferating self-tumor antigen-specific CD8+ T cells, and specifically, to: a method for selecting an epitope, which is recognized by CD8+ T cells, from self-tumor antigens present in the blood of an individual cancer patient, and then isolating self-tumor antigen-specific CD8+ T cells by using a peptide of the selected epitope; and a method for mass proliferating CD8+ T cells by using the same. According to the present invention, self-tumor antigen-specific CD8+ T cells can be isolated by using a peptide of an epitope of self-tumor antigen CD8 T cells, and not foreign antigens, present in the blood of an individual cancer patient. Therefore, T cells recognizing self-tumor antigens allow cancer cells, which are derived from the patient's own cells, to be effectively selected and removed, and thus can be applied to treatment and alleviation of cancer without side effects.
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