03-02-2011 дата публикации
Номер: WO2011013987A3
Автор:
GONG, Young Dae,
CHO, Hee Yeong,
LEE, Tae Ho,
CHOI, Gil Don,
JEON, Moon Kook,
PARK, Woo Kyu,
KONG, Jae Yang,
HWANG, Soon Hee,
JEONG, Dae Young,
LEE, Bong Yong,
UM, Key An,
KIM, Jae Sun,
RYU, Keun Ho,
RYU, Je Ho,
KIM, Shin Ae,
HAN, Hye Young,
SON, Hyun Joo,
LEE, Hyun Jung,
KIM, Young Hyuk,
PARK, Sung Hoon
Принадлежит:
The present invention relates to a 2,2-disubstituted-2H-chromene compound, and to the medicinal use of the compound as an agent for preventing, controlling, and treating diseases related to the regulation of glucocorticoids using the selective inhibitory activity of the compound against the 11β-HSD1 enzyme. The 2,2-disubstituted-2H-chromene compound of the present invention is useful as an agent for preventing, controlling, and treating disorders related to the regulation of glucocorticoids, in which human-derived 11β-HSD1 enzyme is involved, for example metabolic syndrome-related disorders such as type 1 and type 2 diabetes, late diabetic complications, latent autoimmune diabetes in adults (LADA), insulin resistance, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), impaired glucose tolerance, dyslipidemia, arteriosclerosis, hypertension, etc.
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