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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 21. Отображено 21.
04-05-2016 дата публикации

NOVEL ENDOLICHENIC FUNGI AND COMPOSITION FOR PREVENTING OR TREATING GASTRIC CANCER OR COLORECTAL CANCER, COMPRISING EXTRACT THEREOF AS ACTIVE INGREDIENT

Номер: KR101618503B1
Автор: KIM, HAN GUN, HUR, JAE SEOUN, KIM, KYUNG KEUN
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION OF SUNCHON NATIONAL UNIVERSITY, SUNCHEON RESEARCH CENTER FOR NATURAL MEDICINES

The present invention relates to novel lichen-forming fungi EL002332 (accession number KACC 93220P) separated from the genus Endocarpon, and to a composition for preventing or treating gastric cancer or colorectal cancer, comprising an extract thereof as an active ingredient. The extract of the novel lichen-forming fungi EL002332 exhibits the cytotoxicity with respect to cancer cells, induces the apoptosis of gastric cancer cells of the cancer cells, and exhibits effects in reducing a size and a growth rate of a colorectal cancer tissue. COPYRIGHT KIPO 2016 (A1,A2,A3) Control group (B1,B2,B3) Treatment group ...

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Номер записи: 1
21-05-2018 дата публикации

COMPOSITION FOR PREVENTING OR TREATING CALORECTAL CANCER COMPRISING GJD

Номер: KR0101860119B1
Автор: LEE, SOONG IN, KIM, KYUNG KEUN, KIM, HAN GUN
Принадлежит: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

The present invention relates to a composition for preventing or treating colorectal cancer comprising Geijigajakyak Decoction (GJD), wherein the GJD of the present invention inhibits the motor activity of human CRC cells and inhibits tumor formation in a mouse model. In addition, GJD inhibits p-JNK and p-p38 MAPK cell signaling pathways which are involved in invasion regardless of cell viability. Therefore, the GJD of the present invention can be a potent adjuvant chemotherapeutic regimen for CRC, and the composition comprising the GJD may be useful as a medicament and/or functional food for improvement, prevention and/or treatment of the colorectal cancer. COPYRIGHT KIPO 2018 ...

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Номер записи: 2
01-10-2018 дата публикации

APPARATUS AND METHOD FOR PURIFYING REACTOR COOLANT RADIOACTIVE MATERIAL AND CONTROLLING PH OF SAME

Номер: KR1020180105867A
Автор: KIM, HAN GUN, KIM, DUK YONG, KIM, HANG JUN
Принадлежит:

An apparatus and a method for purifying a reactor coolant radioactive material and controlling pH of the same relate to an apparatus applied to a chemical and volume control system (CVCS) including a regenerative heat exchanger, non-regenerative heat exchanger, and a volume control tank, and installed between the non-regenerative heat exchanger and the volume control tank among pathways of the reactor coolant radioactive material. The apparatus includes: a radioactive metal ion collector having a first negative electrode member and a first positive electrode member through which DC power flows, and allowing the reactor coolant discharged from the non-regenerative heat exchanger to pass between the members to collect and accumulate radioactive metal ions and metal particles in the first negative electrode member; a Li ion separation concentrator having a cation exchange membrane between a second positive electrode member and a second negative electrode member, allowing the reactor coolant ...

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Номер записи: 3
26-01-2017 дата публикации

KIT FOR DIAGNOSIS OR PROGNOSTIC ANALYSIS OF COLON CANCER

Номер: KR1020170010256A
Автор: KIM, KYUNG KEUN, BAE, JEONG A, KIM, HANG GUN
Принадлежит:

Provided are a kit for the diagnosis or prognostic analysis of colon cancer, and a method for detecting a marker for diagnosing colon cancer. Also, provided is a biomarker for more precise early diagnosis of colon cancer. According to the present invention, the biomarker can diagnose risks for malignant colon polyp which can be overlooked in an existing diagnosis of colon cancer. COPYRIGHT KIPO 2017 ...

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Номер записи: 4
14-10-2016 дата публикации

상피세포 성장인자 수용체 차단 치료제에 대해 저항성을 갖는 암을 치료할 수 있는 항암제의 스크리닝 방법

Номер: KR0101665565B1
Автор: 김경근, 배정아, 김항건
Принадлежит: 전남대학교산학협력단

... 본 발명은 KITENIN/ErbB4 - Dvl2 - c-Jun 축의 신호전달 경로 활성화 차단제를 유효성분으로 포함하는 항암제, 상기 항암제를 스크리닝하는 방법, 상기 항암제 스크리닝용 조성물, 상피세포 성장인자 수용체(EGFR) 차단 치료제에 대한 반응성 여부 판단에 필요한 정보를 제공하는 방법, 및 상피세포 성장인자 수용체(EGFR) 차단 치료제에 대한 반응성 여부 판단용 키트에 관한 것이다. 본 발명에 의하면 EGFR 차단 치료제에 대해 반응성을 보이지 않는 암에 대한 항암제 후보물질을 효과적으로 선별할 수 있으며, 본 발명의 상기 항암제 후보물질은 EGFR 차단 치료제에 의해서도 항암효과를 얻지 못하는 암환자군의 치료에 항암 보조제로 사용될 수 있다. 또한, 본 발명에 의하면, EGFR 차단 치료제를 사용할 것인지 여부와 EGFR 차단 치료제에 의한 치료 예후를 판단하는데 있어서 중요하고 필요한 정보를 제공할 수 있다.

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Номер записи: 5
25-05-2016 дата публикации

APPARATUS AND METHOD FOR DECONTAMINATING WASTE ION-EXCHANGE RESIN AND WASTE ACTIVATED CARBON CONTAMINATED WITH RADIOACTIVE SUBSTANCE

Номер: KR101624453B1
Автор: KIM, HAN GUN, KIM, DUK YONG, KIM, HANG JUN
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION OF SUNCHON NATIONAL UNIVERSITY

The present invention relates to an apparatus for decontaminating a waste ion-exchange resin or a waste activated carbon contaminated with a radioactive substance, and a method for decontaminating a waste ion-exchange resin or a waste activated carbon contaminated with a radioactive substance by using the apparatus. The apparatus includes: a dissolving tank; a filling tank; an electrodeposition tank; a scrapper; and first to sixth connection pipes. The method includes: a filling step; a first eluting step; an electrolysis step; a capturing step; a second eluting step; a third eluting step; and a collecting step. According to the present invention, the waste ion-exchange resin or the waste activated carbon contaminated with the radioactive substance is decontaminated to remove the radioactive substance without a concern about generation and decontamination of a secondary waste fluid, to be reused for eliminating a radioactive substance in a liquid radioactive waste or to be disposed as a ...

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Номер записи: 6
31-12-2018 дата публикации

원자로냉각재 방사성 물질 정화/pH 조절 장치 및 방법

Номер: KR0101934012B1
Автор: 김항건, 김덕용, 김항준
Принадлежит: 순천대학교 산학협력단

... 개시된 본 발명에 따른 원자로냉각재 방사성물질 정화/pH 조절 장치 및 방법 중 원자로냉각재 방사성물질 정화/pH 조절 장치는, 재생 열교환기(10)와 비재생 열교환기(20) 및 체적 제어 탱크(50)를 포함하는 화학 및 체적제어 계통(CVCS)에 적용되고, 원자로냉각재의 경로 중 상기 비재생 열교환기(20)와 체적 제어 탱크(50) 사이에 설치되는 장치에 관한 것으로서, 음(-)극이 연결된 제1 음극 부재(112)와, 양(+)극이 연결된 제1 양극 부재(114)를 구비하며, 상기 비재생 열교환기(20)에서 배출된 원자로냉각재를 직류전원이 흐르는 상기 제1 음극 부재(112)와 제1 양극 부재(114) 사이에 통과시켜 상기 제1 음극 부재(112)에 방사성 금속이온 및 금속입자가 집적되면서 회수되게 하는 방사성 금속이온 회수기(110); 일측에 양(+)극이 연결되는 제2 양극 부재(124)와, 타측에 음(-)극이 연결되는 제2 음극 부재(122) 및 제2 양극 부재(124)와 제2 음극 부재(122)의 사이에 설치되어 양이온을 통과시키는 양이온 교환막(126)을 구비하며, 상기 방사성 금속이온 회수기(110)를 통과한 원자로냉각재는 상기 제2 양극 부재(124)와 양이온 교환막(126) 사이를 통과하여 상기 체적 제어 탱크(50)로 유입되고, 제2 음극 부재(122)와 양이온 교환막(126) 사이에는 순수를 계속 재순환시켜 원자로냉각재에서 생성되는 상기 양이온 교환막(126)을 통과한 Li+ 이온이 상기 제2 음극 부재(122) 쪽으로 이동 및 분리되도록 하는 Li 이온 분리 농축기(120); 및, 상기 Li 이온 분리 농축기(120)에서 분리된 Li7을 다시 Li 이온 분리 농축기(120)로 재순환 하면서 재순환 과정에서 Li7을 농축하는 Li7농축 탱크(130)를 포함한다.

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Номер записи: 7
04-08-2017 дата публикации

COMPOSITION FOR PREVENTING OR TREATING LUNG CANCER COMPRISING ATRANORIN OR SALT THEREOF AS ACTIVE INGREDIENT

Номер: KR1020170089822A
Автор: KIM, HAN GUN, HUR, JAE SEOUN, KIM, KYUNG KEUN, ZHOU, RUI
Принадлежит:

The present invention relates to a composition for prevention or treatment of lung cancer containing atranorin or an acceptable salt thereof as an active ingredient. The composition of the present invention down-regulates downstream target genes of β-catenin/LEF and c-jun/AP-1 by reducing the activity of KITENIN-mediated AP-1 and beta-catetin-mediated TOPELASH and having influence on the expression of KAI1 and KITENIN, and can inhibit the growth and metastasis of lung cancer cells by reducing RhoGTPase activity. Therefore, the composition containing atranorin or the salt thereof as the active ingredient can improve treatment effectiveness by early diagnosis and treatment of lung cancer metastasis having high mortality. COPYRIGHT KIPO 2017 ...

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Номер записи: 8
27-07-2016 дата публикации

슈도사이펠라리아 코리아세아 추출물, 또는 피스키오스포린 또는 이의 염을 유효성분으로 포함하는 폐암 전이 억제용 조성물

Номер: KR0101643058B1
Автор: 김항건, 허재선, 양의
Принадлежит: 순천대학교 산학협력단, (재) 순천천연물의약소재개발연구센터

... 본 발명은 슈도사이펠라리아 코리아세아(Pseudocyphellaria coriacea) 추출물, 피스키오스포린(physciosporin) 및 이의 염으로 이루어진 군으로부터 선택된 하나 이상을 유효성분으로 포함하는 폐암 전이 억제용 조성물에 관한 것이다.

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Номер записи: 9
04-07-2016 дата публикации

COMPOSITION FOR INHIBITING LUNG CANCER METASTASIS, COMPRISING PSEUDOCYPHELLARIA CORIACEA EXTRACT, OR PHYSCIOSPORIN OR SALT THEREOF AS ACTIVE INGREDIENT

Номер: KR1020160078062A
Автор: KIM, HAN GUN, HUR, JAE SEOUN, YANG, YI
Принадлежит:

The present invention relates to a composition for inhibiting lung cancer metastasis, comprising at least one selected from the group consisting of a Pseudocyphellaria coriacea extract, Physciosporin, and a salt thereof, as active ingredients. The active ingredients included in the composition of the present invention can be used in a safe manner. COPYRIGHT KIPO 2016 ...

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Номер записи: 10
21-06-2016 дата публикации

COMPOSITION FOR INHIBITING GROWTH OF TUMOR STEM CELLS, COMPRISING STICTA WEIGELII EXTRACT, BREVICID X, OR SALT THEREOF AS ACTIVE INGREDIENT

Номер: KR1020160071023A
Автор: KIM, HAN GUN, HUR, JAE SEOUN, THANH NGUYEN THI
Принадлежит:

The present invention relates to an anticancer supplement agent and a composition for inhibiting the growth of tumor stem cells, comprising at least any one selected from the group consisting of a Sticta weigelii extract, brevicid X, and a pharmaceutically acceptable salt of the brevicid X. The composition inhibits the expression of ALDH-1, CD133, CD44, Msi-1, Lgr-5, Bmi-1, EphB-1, GLI-1, GLI-2, and SMO, which is a marker of tumor stem cells, induces the apoptosis of the tumor stem cells, and exhibits effects in inhibiting the differentiation into cancer cells and self-regeneration of the tumor stem cells. COPYRIGHT KIPO 2016 ...

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Номер записи: 11
07-06-2018 дата публикации

대장암 진단 또는 예후 분석용 키트

Номер: KR0101864726B1
Автор: 김경근, 배정아, 김항건
Принадлежит: 전남대학교산학협력단

... 본 발명은 대장암 진단 또는 예후 분석용 키트 및 대장암 진단마커를 검출하는 방법을 제공한다. 본 발명은 종래보다 정확한 대장암 발병 조기 진단할 수 있는 바이오마커를 제공한다. 본 발명에 따르면, 상기 바이오마커는 종래의 대장암 진단에서 간과될 수 있는 대장 용종의 악성 발병 가능성을 진단 할 수 있다.

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Номер записи: 12
05-04-2016 дата публикации

COMPOSITION FOR INHIBITING COLORECTAL CANCER METASTASIS, CONTAINING THAMNOLIA VERMICULARIS EXTRACT OR CETRARIA ERICETORUM EXTRACT, OR THAMNOLIC ACID OR FUMARPROTOCETRARIC ACID, OR SALT THEREOF AS ACTIVE INGREDIENT

Номер: KR101609470B1
Автор: HUR, JAE SEOUN, KIM, HAN GUN, THANH NGUYEN THI, KIM, KYUNG KEUN
Принадлежит: INDUSTRY-ACADEMIC COOPERATION FOUNDATION OF SUNCHON NATIONAL UNIVERSITY, SUNCHEON RESEARCH CENTER FOR NATURAL MEDICINES

The present invention relates to a composition for inhibiting colorectal cancer metastasis, containing, as an active ingredient, at least one selected from the group composed of a Thamnolia vermicularis extract, a Cetraria ericetorum extract, thamnolic acid, fumarprotocetraric acid, and a salt thereof. COPYRIGHT KIPO 2016 ...

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Номер записи: 13
20-09-2018 дата публикации

DEVICE AND METHOD FOR PURIFYING NUCLEAR REACTOR COOLANT RADIOACTIVE MATERIAL/ADJUSTING PH

Номер: WO2018169130A1
Автор: KIM, Han Gun, KIM, Duk Yong, KIM, Hang Jun
Принадлежит:

The present invention provides a device and a method for purifying a nuclear reactor coolant radioactive material/adjusting the pH thereof. The device for purifying a nuclear reactor coolant radioactive material/adjusting the pH thereof is applied to a chemical and volume control system (CVCS) comprising a regenerative heat exchanger (10), a non-regenerative heat exchanger (20), and a volume control tank (50), and is installed between the non-regenerative heat exchanger (20) and the volume control tank (50) within a path of the nuclear reactor coolant. The device for purifying a nuclear reactor coolant radioactive material/adjusting the pH thereof comprises: a radioactive metal ion collecting unit (110) comprising a first cathode member (112) to which a cathode (-) is connected and a first anode member (114) to which an anode (+) is connected, the radioactive metal ion collecting unit (110) being configured such that a nuclear reactor coolant discharged from the non-regenerative heat exchanger ...

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Номер записи: 14
04-08-2016 дата публикации

PRIMER FOR DETECTING ULVA LINZA AND DETECTION KIT COMPRISING SAME

Номер: KR1020160092195A
Автор: KIM, HAN GUN, KIM, KWANG YOUNG, PARK, SO YEON, KO, YOO SEUNG, KANG, EUN JU, KIM, JU HYOUNG
Принадлежит:

The present invention relates to a primer for detecting Ulva linza and a detection kit comprising the same. The primer set for qualifying and quantifying Ulva linza DNA comprises a forward primer having the nucleotide sequence of SEQ ID NO 1 and a reverse primer having the nucleotide sequence of SEQ ID NO 2. According to the present invention, the primer set enables a user to predict relative concentration of Ulva linza existing in coast by using a method for predicting relative concentration of the Ulva linza in real time using the same, thereby being expected to reduce damages caused by the water-bloom phenomenon in the coast and shore. COPYRIGHT KIPO 2016 ...

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Номер записи: 15
17-07-2017 дата публикации

COMPOSITION FOR PREVENTING OR TREATING LUNG CANCER COMPRISING THALLUS EXTRACT, ATRANORIN, OR SALT THEREOF AS ACTIVE INGREDIENT

Номер: KR1020170082762A
Автор: KIM, HAN GUN, HUR, JAE SEOUN, KIM, KYUNG KEUN, ZHOU RUI
Принадлежит:

The present invention relates to a composition for preventing or treating lung cancer comprising a thallus extract of Everniastrum vexans, atranorin, or an acceptable salt thereof as an active ingredient. The composition of the present invention reduces KITENIN-mediated AP-1 activity and β-catechin-mediated TOPELASH activity, influences the expression of KAI1 and KITENIN, thereby downregulating the downstream target gene of β-catechin/LEF and c-jun/AP-1, and reduces RhoGTPase activities, and thus can suppress the growth and metastasis of lung cancer cells. Accordingly, the composition comprising a thallus extract, atranorin, or a salt thereof as an active ingredient can be used to diagnose and treat the metastasis of lung cancer with high mortality in its early stage, thereby enhancing the treatment effect. COPYRIGHT KIPO 2017 ...

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Номер записи: 16
28-05-2018 дата публикации

스틱타 위겔리 추출물, 또는 브레비시드 X 또는 이의 염을 유효성분으로 포함하는 종양줄기세포 성장 억제용 조성물

Номер: KR0101861160B1
Автор: 김항건, 허재선, 탄누엔티
Принадлежит: 순천대학교 산학협력단, (재) 순천천연물의약소재개발연구센터

... 본 발명은 종양줄기세포 표지자인 ALDH-1, CD133, CD44, Msi-1, Lgr-5, Bmi-1, EphB-1, GLI-1, GLI-2 및 SMO의 발현을 억제하고, 종양줄기세포의 사멸을 유도하며, 종양줄기세포의 자가재생 및 암세포로의 분화를 억제시키는 효과를 나타내는 스틱타 위겔리(S. weigelii) 추출물, 브레비시드 X(brevicid X) 및 브레비시드 X(brevicid X)의 약제학적으로 허용가능한 염으로 이루어진 군으로부터 선택된 어느 하나 이상을 유효성분으로 포함하는 종양줄기세포 성장 억제 조성물 및 항암 보조제에 관한 것이다.

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Номер записи: 17
30-03-2016 дата публикации

COMPOSITION FOR SUPPRESSING CANCER METASTASIS COMPRISING FLAVOCETRARIA CUCULLATA EXTRACT, OR USNIC ACID OR SALT THEREOF, AS ACTIVE INGREDIENT

Номер: KR1020160034752A
Автор: KIM, HAN GUN, HUR, JAE SEOUN, THANH NGUYEN THI
Принадлежит:

The present invention relates to a composition for suppressing stomach cancer or lung cancer metastasis comprising any one or more selected from the group consisting of a Flavocetraria cucullata extract, and usnic acid and pharmaceutically or sitologic acceptable salts thereof, as an active ingredient. In addition, the present invention relates to a composition for anti-cancer comprising the Flavocetraria cucullata extract as an active ingredient, wherein the Flavocetraria cucullata extract does not show cytotoxicity with respect to common cells. COPYRIGHT KIPO 2016 ...

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Номер записи: 18
05-01-2017 дата публикации

잎파래 검출용 프라이머 및 이를 포함하는 검출키트

Номер: KR0101692958B1
Автор: 김항건, 김광용, 박소연, 고유승, 강은주, 김주형
Принадлежит: 순천대학교 산학협력단, 전남대학교산학협력단

... 본 발명은 잎파래(Ulva linza) 검출용 프라이머 및 이를 포함하는 검출키트에 관한 것으로, 서열번호 1의 염기서열을 가지는 정방향 프라이머 및 서열번호 2의 염기서열을 가지는 역방향 프라이머로 이루어진 것을 특징으로 하는 잎파래(Ulva linza) DNA의 정성 또는 정량용 프라이머 세트를 이용한 잎파래 종균의 상대적 농도의 실시간 예측 방법을 이용하면, 연안내 존재하는 잎파래 종균의 상대적인 농도를 예측할 수 있고, 이를 통해 연안 및 해안의 녹조현상으로 인한 피해를 줄일 수 있을 것으로 기대된다.

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Номер записи: 19
11-02-2016 дата публикации

METHOD FOR SCREENING ANTICANCER DRUG CAPABLE OF TREATING CANCER RESISTANT TO EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS

Номер: KR1020160014204A
Автор: KIM, KYUNG KEUN, BAE, JEONG A, KIM, HANG GUN
Принадлежит:

The present invention relates to an anticancer drug containing an inhibitor suppressing the activation of a signal transduction pathway of the KITENIN/ErbB4 - Dvl2 - c-Jun axis as an active ingredient, a method for screening the anticancer drug, a composition for screening the anticancer drug, a method for providing information required to determine therapeutic response to epidermal growth factor receptor (EGFR) inhibitors, and a kit for determining therapeutic response to the epidermal growth factor receptor (EGFR) inhibitors. According to the present invention, anticancer drug candidates against the cancer resistant to EGFR inhibitors can be effectively sorted, and the anticancer drug candidates can be used as anticancer adjuvants for treating a cancer patient group who does not have therapeutic response to the EGFR inhibitors. In addition, according to the present invention, information which is important and required for determining whether to use EGFR inhibitors or not and evaluating ...

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Номер записи: 20
25-08-2015 дата публикации

MICROSPHERE BEAD AND QUANTIFICATION METHOD FOR PROTEIN USING SAME

Номер: KR101547058B1
Автор: KIM, HAN GUN, LEE, HO BIN, LEE, SANG DON
Принадлежит: INDUSTRY-ACADEMY COOPERATION CORPS OF SUNCHON NATIONAL UNIVERSITY

The present invention relates to a microsphere bead and a quantification method for a protein using the same. According to the present invention, a small amount of a protein can be quantified by using a microsphere-bead which bonds a microsphere displayed with fluorescence and a bead bound with a monoclonal antibody capable of specifically reacting to a specific protein. The microsphere bead is capable of quantity analyzing with one sample with respect to multiple proteins at the same time and analyzing biomolecules at the minimum concentration and various concentrations, and can be usefully used in protein analysis, disease diagnosis, medicine development, etc. COPYRIGHT KIPO 2015 ...

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Номер записи: 21