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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 22. Отображено 22.
12-03-2018 дата публикации

COMPOSITION FOR RADIOPROTECTANT

Номер: KR1020180026214A
Автор: KIM, MIN JUNG, PARK, SUN HOO, SHIN, DONG YEOP, HWANG, YOU JUNG, KANG, JIN KYU, MYUNG, JAE KYUNG, SEO, SONG WON, SEONG, KI MOON, SHIM, SE HWAN, LEE, SUN JU, LEE, SEUNG BUM, LEE, SEUNG SOOK, JANG, WON SUK, JANG, HYO SUN, KIM, AREUMNURI
Принадлежит:

The present invention relates to a composition for a radioprotectant, and more particularly, to a composition for a radioprotectant, which comprises a compound represented by the chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient, and thus the composition can be used for the composition for the radioprotectant by inhibiting apoptosis and DNA damage by radiation exposure or irradiation. In addition, the composition for the radioprotectant may be used to protect radiation damage in various cells including hematopoietic stem cells susceptible to radiation damage, or to promote regeneration after damage has occurred, thereby being used to treat patients with radiation exposure. COPYRIGHT KIPO 2018 ...

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Номер записи: 1
19-05-2016 дата публикации

BOMAB PHANTOM PLACING DEVICE FOR EFFICIENT CORRECTION OF STANDING TYPE WHOLE BODY COUNTER

Номер: KR1020160056172A
Автор: YOO, JAE RYOUNG, HA, WI HO, YOON, SEOK WON, PARK, MIN JEONG, PARK, SE YOUNG, PARK, SUN HOO, LEE, SEUNG SOOK, LEE, JIN KYUNG
Принадлежит:

According to the present invention, a BOMAB phantom placing device for the efficient correction of a standing type whole body counter includes: a lower support part accepting and supporting a leg part of a BOMAB phantom; a body support part combined with an upper part of the lower support part, and of which upper surface is horizontal with the ground to support a body of the BOMAB phantom independently from the leg part of the BOMAB phantom; an upper support part extended upward from the body support part, and supporting a rear side of a head and the body of the BOMAB phantom; and an arm support part installed in the upper support part and supporting an arm part of the BOMAB phantom. COPYRIGHT KIPO 2016 ...

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Номер записи: 2
14-05-2010 дата публикации

TRANSPARENT ELECTROCHROMIC PLATE AND METHOD FOR MANUFACTURE THEREOF

Номер: KR2010053299A2
Автор: PARK, Sun Hoo, YUN, Young Hoon, JI, Yoo Kang
Принадлежит:

The present invention relates to a transparent electrochromic plate used for improving a response rate, and to a method for the manufacture thereof. Said transparent electrochromic plate comprises: a pair of transparent plates spaced apart from one another at a predetermined distance; a pair of transparent electrodes respectively arranged inside said pair of transparent plates; a cathodic colouration layer which is situated in either one of said pair of transparent electrodes and expresses colour when in the reduced state; an anodic colouration layer which is situated in the remaining one of said pair of transparent electrodes so as to face said cathodic colouration layer, and which expresses colour when in the oxidised state; and an electrolyte layer which is interposed between said cathodic colouration layer and said anodic colouration layer and facilitates electromigration between said cathodic colouration layer and said anodic colouration layer.

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Номер записи: 3
12-03-2018 дата публикации

COMPOSITION FOR DIAGNOSING RADIATION EXPOSURE AND METHOD FOR DIAGNOSING RADIATION EXPOSURE USING SAME

Номер: KR1020180026215A
Автор: KIM, MIN JUNG, PARK, SUN HOO, SHIN, DONG YEOP, HWANG, YOU JUNG, KANG, JIN KYU, KIM, AREUMNURI, MYUNG, JAE KYUNG, SEO, SONG WON, SEONG, KI MOON, LEE, SUN JU, LEE, SEUNG BUM, JANG, WON SUK, JANG, HYO SUN
Принадлежит:

The present invention relates to a composition for diagnosing radiation exposure, and a method for diagnosing radiation exposure using the same. More specifically, it is possible to quickly and accurately diagnose radiation exposure from blood by using C-X-C motif ligand 3 (CXCL3), CXCL5, interleukin (IL)-1β, IL-15, IL-19, C-C motif receptor 1 (CCR1), notch homolog 2 (NOTCH2), growth arrest and DNA damage-inducible 45 (GADD45), B-cell lymphoma 2 (BCL2), and GATA binding protein 3 (GATA3) which are genes highly sensitive to radiation. Moreover, provided are a DNA chip for diagnosing radiation exposure including the gene as a biomarker, and a kit for diagnosing radiation exposure including a probe or a primer specifically binding to the gene. Further, it is possible to improve effectiveness in radiation therapy by developing drugs to increase sensitivity to radiation by targeting the gene, and the composition can be applied to diagnose or predict a degree of exposure to background radiation ...

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Номер записи: 4
05-10-2018 дата публикации

장 오가로이드 상태 및 ROCK 저해제 첨가시기의 복합처리를 통한 장 오가로이드의 효율적인 장기냉동동결보존방법

Номер: KR0101904182B1
Автор: 이승범, 박선후, 한성훈, 심세환, 김민정, 장원석, 이선주, 명재경, 이승숙, 진영우
Принадлежит: 한국원자력의학원

... 본 발명은 장 오가로이드 상태 및 ROCK 저해제 첨가시기의 복합처리를 통한 장 오가로이드의 효율적인 장기냉동동결보존방법을 제공한다. 본 발명에 따르면 생체 외에서 배양된 장 오가로이드를 단일세포 보다 온전한 오가로이드 (intact intestine organoid) 형태로 냉동동결보존 후 해동시 생존율이 높음을 확인하였다. 3개월 이상의 장기냉동동결시에는 ROCK(Rho-kinase) 저해제를 동결배지에 직접 첨가법이 전처리 및 해동 후 처리보다 생존회복율이 현저히 높음을 알수 있었다. 또한 해동 후 배양된 장 오가로이드의 특성 분석 결과 crypt-villi 구조를 가지는 in vivo intestine의 형태학적 특성이 그대로 유지함을 관찰할 수 있었다. 따라서, 본 발명에 적용된 고효율 냉동동결보존법은 오가로이드 기반 치료(organoid-based therapy)에 필수적인 많은 양의 세포를 제공함으로써 효과적인 장 질병과 손상 치료에 적용에 활용될 수 있을 것으로 사료된다.

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Номер записи: 5
19-04-2017 дата публикации

COMPOSITION FOR TREATING CANCER COMPRISING INHIBITOR OF PLEIOTROPIC REGULATOR 1 (PLRG1)

Номер: KR1020170042490A
Автор: LEE, KEE HO, KIM, SUNG SUB, KIM, YEON SOO, PARK, EUN RAN, SHIN, HYUN JIN, LEE, EUN JU, HAM, YONG HO, KIM, SANG BUM, PARK, SUN HOO, HAN, CHUL JU, HONG, SUNG HEE, KIM, YANG HYUN, KIM, JUNG MIN, KIM, MI YEUN, KANG, MOON KYOUNG, SONG, EUN YEONG
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a pleiotropic regulator 1 (PLRG) inhibitor as an active ingredient for preventing or treating cancer, a method for treating cancer including a step of administering the composition to a subject, a composition for diagnosis of cancer comprising a formulation for determining a level of expression of PLRG1, a method for providing information for cancer diagnosis including a step of determining a level of expression of PLRG1, and a method for screening a formulation for preventing or treating cancer. Pleiotropic regulator (PLRG1) is over-expressed in cancer cells. When the expression of PLRG1 is being inhibited, it is possible to induce apoptosis of cancer cells specifically. Thus, the PLRG1 inhibitor according to the present invention has an excellent effect as an anti-cancer drug without side effects, and can be used for cancer diagnosis or anti-cancer drug screening through the determination of a level of expression ...

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Номер записи: 6
29-07-2010 дата публикации

MARKER FOR LIVER-CANCER DIAGNOSIS AND RECURRENCE AND SURVIVAL PREDICTION, A KIT COMPRISING THE SAME, AND PROGNOSIS PREDICTION IN LIVER-CANCER PATIENTS USING THE MARKER

Номер: WO2010085124A3
Автор: LEE, Kee Ho, PARK, Eun Ran, CHA, Pu Hyeon, KIM, Sang Bum, PARK, Sun Hoo, LEE, Dong Hyoung, WOO, Seon Rang, HAN, Chul Ju, HAM, Yong Ho, LEE, Eun Ju, PARK, Myoung Jin, HWANG, Sang Gu
Принадлежит:

The present invention relates to a composition used in marker detection for liver-cancer diagnosis or prognosis prediction comprising a preparation for measuring the level of expression of UQCRH (ubiquinol-cytochrome c reductase hinge protein), to a kit comprising the composition, to a microarray for diagnosing liver cancer using the marker, to a method for detecting the marker, and to the prediction of recurrence following surgery in liver-cancer patients. According to the present invention, the marker has been judged to be able to greatly contribute to predicting the recurrence and the prognosis for survival following surgery in individuals who have had an early diagnosis and liver resection surgery for liver cancer, and provides significance to treatment targets for subsequent liver-cancer treatment.

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Номер записи: 7
07-03-2018 дата публикации

METHOD FOR PROMOTING REPROGRAMMING EFFICIENCY OF INDUCED PLURIPOTENT STEM CELLS BY LONG-TERM CELL CULTURE AFTER IRRADIATION

Номер: KR1020180023641A
Автор: LEE, SEUNG BUM, PARK, SUN HOO, HAN, SUNG HOON, KIM, MIN JUNG, SHIM, SE HWAN, JANG, WON SUK, LEE, SUN JU, MYUNG, JAE KYUNG, LEE, SEUNG SOOK, JIN, YOUNG WOO
Принадлежит:

The present invention provides a method for promoting a reprogramming efficiency of induced pluripotent stem cells by long-term cell culture after irradiation. According to the present invention, the reprogramming efficiencies of induced pluripotent stem cells is investigated after culturing the irradiated cells for different number of days. A production of induced pluripotent stem cells decreases in the cells cultured for three days but remarkably increases in the cells cultured for 14 days. Moreover, long-term cultured cells after irradiation proves that reprogramming of the induced pluripotent stem cells is promoted to have high efficiency by confirming cells from the reprogrammed cells with high efficiency through the characteristic analysis. Therefore, the method for promoting reprogramming induced pluripotent stem cells by irradiation of the present invention can be utilized for research on the induced pluripotent stem cells generation efficiency promoting factor and mechanism. COPYRIGHT ...

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Номер записи: 8
14-05-2010 дата публикации

TRANSPARENT ELECTROCHROMIC PLATE AND METHOD FOR MANUFACTURE THEREOF

Номер: WO2010053299A3
Автор: PARK, Sun Hoo, YUN, Young Hoon, JI, Yoo Kang
Принадлежит:

The present invention relates to a transparent electrochromic plate used for improving a response rate, and to a method for the manufacture thereof. Said transparent electrochromic plate comprises: a pair of transparent plates spaced apart from one another at a predetermined distance; a pair of transparent electrodes respectively arranged inside said pair of transparent plates; a cathodic colouration layer which is situated in either one of said pair of transparent electrodes and expresses colour when in the reduced state; an anodic colouration layer which is situated in the remaining one of said pair of transparent electrodes so as to face said cathodic colouration layer, and which expresses colour when in the oxidised state; and an electrolyte layer which is interposed between said cathodic colouration layer and said anodic colouration layer and facilitates electromigration between said cathodic colouration layer and said anodic colouration layer.

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Номер записи: 9
31-01-2017 дата публикации

ARTIFICIAL INTESTINAL FISTULA

Номер: KR101700601B1
Автор: SHIM, SE HWAN, PARK, SUN HOO, YANG, MI HYUN, LEE, CHANG SUN, JANG, WON SUK, CHO, MIN SOO, BAE, CHANG HWAN, LEE, SEUNG SOOK
Принадлежит: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES

The present invention provides an artificial intestinal fistula comprising: an intestine connection pipe disposed in a cut intestine; a branch pipe having one end connected with one side of the intestine connection pipe, and the other end protruding to the outside of skin; a first cap disposed at the other end of the branch pipe, and opening and closing the branch pipe; a balloon disposed in the intestine connection pipe, and expanded by air fed from the outside to open and close the inside of the intestine connection pipe; and an air hose having one end connected with the balloon, and supplying air to the balloon or discharging air from the balloon. According to the present invention, a branch pipe which may be opened and closed is connected with one side of an intestine connection pipe disposed in the large intestine or the small intestine of a patient, and an excretion pocket is connected with the branch pipe, so the branch pipe can be opened and closed and excrement can be treated according ...

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Номер записи: 10
31-01-2017 дата публикации

CD105를 포함하는 줄기세포능을 가진 섬유아세포 분리용 바이오마커 조성물 및 이를 이용한 줄기세포능을 가진 섬유아세포 분리 방법

Номер: KR0101700598B1
Автор: 이승범, 박선후, 김민정, 심세환, 이승숙, 신혜윤, 이선주, 장원석, 진영우
Принадлежит: 한국원자력의학원

... 본 발명은 CD105를 포함하는 줄기세포능을 가진 섬유아세포 분리용 바이오마커 조성물 및 이를 이용한 줄기세포능을 가진 섬유아세포 분리 방법에 관한 것이다. 줄기세포능을 가진 섬유아세포의 선택적 분리를 평가하는데 유용한 바이오 표면마커로써 CD105 항체를 제공한다. 본 발명에 따르면 마우스 피부 진피세포에서 분리된 섬유아세포는 CD73 발현이 되지 않고 섬유아세포 특이적 마커 발현 확인으로 중간엽줄기세포와는 구별됨을 확인하였다. 또한 지속적인 계대배양시 특이적으로 감소하는 CD105 표면마커 발현에 따른 CD105 양성 및 음성 섬유아세포들을 분리한 후 줄기세포 분화능 비교분석시 CD105 양성 섬유아세포에서 다분화능이 매우 높음을 알 수 있었다. 따라서, 본 발명에서 선별된 CD105를 이용함으로써 줄기세포능 유무가 있는 섬유아세포를 선택적으로 분리할 수 있는 방법 개발에 활용될 수 있을 것이다.

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Номер записи: 11
06-08-2018 дата публикации

방사선 피폭 진단용 조성물 및 이를 이용한 방사선 피폭 진단방법

Номер: KR0101885596B1
Автор: 김민정, 박선후, 신동엽, 황유정, 강진규, 김아름누리, 명재경, 서성원, 성기문, 이선주, 이승범, 장원석, 장효선
Принадлежит: 한국원자력의학원

... 본 발명은 방사선 피폭 진단용 조성물 및 이를 이용한 방사선 피폭 진단방법에 관한 것으로, 더욱 상세하게는, 방사선에 대해 높은 감수성을 가지는 유전자인 CXCL3, CXCL5, IL-1β, IL-15, IL-19, CCR1, NOTCH2, GADD45, BCL2 및 GATA3를 이용하여 혈액으로부터 빠르고 정확하게 방사선 피폭을 진단할 수 있다. 또한, 본 발명은 상기 유전자를 바이오마커로 포함하는 방사선 피폭 진단용 DNA 칩 및 상기 유전자에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 방사선 피폭 진단용 키트를 제공할 수 있다. 또한, 상기 유전자를 타겟으로 하여 방사선 민감성을 높이는 약물을 개발함으로써 방사선 치료 효과를 증진시킬 수 있고, 방사선 관련 종사자 및 자연 방사선 노출로부터 방사선 피폭 정도를 예측하거나 진단하기 위해 활용될 수 있다.

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Номер записи: 12
29-07-2010 дата публикации

MARKER FOR LIVER-CANCER DIAGNOSIS AND RECURRENCE AND SURVIVAL PREDICTION, A KIT COMPRISING THE SAME, AND PROGNOSIS PREDICTION IN LIVER-CANCER PATIENTS USING THE MARKER

Номер: KR2010085124A2
Автор: LEE, Kee Ho, PARK, Eun Ran, CHA, Pu Hyeon, KIM, Sang Bum, PARK, Sun Hoo, LEE, Dong Hyoung, WOO, Seon Rang, HAN, Chul Ju, HAM, Yong Ho, LEE, Eun Ju, PARK, Myoung Jin, HWANG, Sang Gu
Принадлежит:

The present invention relates to a composition used in marker detection for liver-cancer diagnosis or prognosis prediction comprising a preparation for measuring the level of expression of UQCRH (ubiquinol-cytochrome c reductase hinge protein), to a kit comprising the composition, to a microarray for diagnosing liver cancer using the marker, to a method for detecting the marker, and to the prediction of recurrence following surgery in liver-cancer patients. According to the present invention, the marker has been judged to be able to greatly contribute to predicting the recurrence and the prognosis for survival following surgery in individuals who have had an early diagnosis and liver resection surgery for liver cancer, and provides significance to treatment targets for subsequent liver-cancer treatment.

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Номер записи: 13
01-07-2010 дата публикации

DIE BOARD WITH SIDE PAD FOR PREVENTING STATIC ELECTRICITY

Номер: KR2010074390A1
Автор: PARK, Sun Hoo
Принадлежит:

The present invention relates to a die board comprising: blades of a rectangular- or triangular-shaped frame attached to one plane of a wood board to cut a film to a specified size; and a cushion pad positioned in empty spaces around the blades to cover the blades. More specifically, the die board comprises a ground wire which goes through the wood board and is connected to each of the blades and the cushion pad for the purpose of releasing to the outside the static electricity generated between the blades and the cushion pad. Thereby, the die board prevents the film from sticking to a panel or the blades due to friction occurring during cutting of the film. Also, the die board includes one or a plurality of insertion grooves formed on one or both sides of a cutting blade at a certain distance, wherein an iron bar for reinforcement support may be provided in the insertion groove(s).

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Номер записи: 14
13-04-2017 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING INHIBITOR OF PLRG1 (PLEIOTROPIC REGULATOR 1) AS ACTIVE INGREDIENT

Номер: WO2017061828A1
Автор: LEE, Kee-Ho, KIM, Sungsub, KIM, Yeon-Soo, PARK, Eun-Ran, SHIN, Hyun Jin, LEE, Eun-Ju, HAM, Yong-Ho, KIM, Sang Bum, PARK, Sun-Hoo, HAN, Chul-Ju, HONG, Sung Hee, KIM, Yang Hyun, KIM, Jung Min, KIM, Mi Yeun, KANG, Moonkyoung, SONG, Eun Yeong
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating cancer comprising an inhibitor of PLRG1 (pleiotropic regulator 1) as an active ingredient, a method for treating cancer comprising a step of administering the composition to an individual, a composition for diagnosing cancer comprising an agent for measuring an expression level of PLRG1, and a method for providing information for diagnosing cancer comprising a step of measuring an expression level of PLRG1, and a method for screening an agent for preventing or treating cancer. PLRG1 (pleiotropic regulator 1) is overexpressed in cancer cells, and when an expression of PLRG1 is inhibited, a cancer cell-specific cell death can be induced. Thus, the inhibitor of PLRG1 of the present invention has an excellent effect as an anticancer agent without side effects, and also can be used to diagnose cancer and screen anticancer agents by measuring an expression level of PLRG1.

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Номер записи: 15
19-05-2017 дата публикации

METHOD FOR DIFFERENTIATING DEGENERATIVE STEM CELL TO MESENCHYMAL STEM CELL THROUGH SINGLE CELL CULTURING BY USING p38-INHIBITOR TREATMENT

Номер: KR1020170055275A
Автор: LEE, SEUNG BUM, PARK, SUN HOO, SHIN, HYE YUN, SHIM, SE HWAN, KIM, MIN JUNG, JANG, WON SUK, LEE, SUN JU, LEE, SEUNG SOOK, JIN, YOUNG WOO
Принадлежит:

The present invention relates to a method for degenerative stem cells to mesenchymal stem cells through single-cell culturing with a p38-inhibitor treatment. According to the present invention, the cells generated through a temporary p38-inhibitor treatment process in the process of differentiating mesenchymal stem cells from degenerative stem cells by using a direct differentiation scheme are checked to be mesenchymal stem cells by a property analysis including morphological properties, surface markers, and multi-differentiability. The cells have colony forming ability, differentiation functions, and especially the efficiency of differentiation into chondrocytes significantly higher than mesenchymal stem cells derived from umbilical cord blood. Accordingly, the method for differentiating the mesenchymal stem cells from degenerative stem cells can be used for development of mesenchymal stem cell lines with higher functionality. COPYRIGHT KIPO 2017 ...

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Номер записи: 16
09-03-2018 дата публикации

방사선 조사 후 장기 세포배양에 의한 유도만능줄기세포 리프로그래밍 효율 증진 방법

Номер: KR0101836860B1
Автор: 이승범, 박선후, 한성훈, 김민정, 심세환, 장원석, 이선주, 명재경, 이승숙, 진영우
Принадлежит: 한국원자력의학원

... 본 발명은 방사선 조사 후 장기 세포배양에 의한 유도만능줄기세포 리프로그래밍 효율 증진 방법을 제공한다. 본 발명에 따르면 방사선이 조사된 세포를 다양한 요일별로 배양 후 유도만능줄기세포로의 리프로그래밍 효율을 조사한 결과, 3일째 배양된 세포는 유도만능줄기세포 생성율이 감소한 반면 14일째 배양된 세포에서는 유도만능줄기세포 생성이 현저히 증가됨을 관찰할 수 있었다. 또한 고효율로 리프로그램된 세포들에서 줄기세포 특성 분석을 통해 유도만능줄기세포임을 확인하여 방사선 조사 후 장기배양된 세포는 유도만능줄기세포 리프로그래밍이 고효율로 증진됨을 증명하였다. 따라서, 본 발명에 적용된 방사선 조사에 의한 유도만능줄기세포 리프로그래밍 증진법은 유도만능줄기세포 생성 효율 증진인자 탐색 및 기전 연구에 활용될 수 있을 것이다.

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Номер записи: 17
28-03-2018 дата публикации

p38 저해제를 처리하여 단층세포배양을 통한 역분화줄기세포에서 중간엽줄기세포로의 분화방법

Номер: KR0101842957B1
Автор: 이승범, 박선후, 신혜윤, 심세환, 김민정, 장원석, 이선주, 이승숙, 진영우
Принадлежит: 한국원자력의학원

... 본 발명은 p38 저해제를 처리하여 단층세포배양을 통한 역분화줄기세포에서 중간엽줄기세포로의 분화방법에 관한 것이다. 본 발명에 따르면 직접분화를 이용한 역분화줄기세포로부터 중간엽줄기세포 분화과정에서 p38 저해제의 일시적인 처리를 통해 생성된 세포가 중간엽줄기세포 특성 분석(형태학적, 표면마커 발현 및 다분화능)으로 중간엽줄기세포임을 확인하였다. 또한 기능적으로 제대혈 유래 중간엽 줄기세포 보다 콜로니 형성능과 분화능, 특히 연골세포로의 분화 효율이 매우 높음을 알 수 있었다. 따라서, 본 발명에 적용된 역분화줄기세포 유래 중간엽줄기세포 분화법을 이용함으로써 보다 기능성이 높은 중간엽줄기세포주 개발에 활용될 수 있을 것이다.

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Номер записи: 18
19-05-2016 дата публикации

BIOMARKER COMPOSITION COMPRISING CD105 FOR ISOLATING MULTIPOTENT FIBROBLAST AND METHOD OF ISOLATING MULTIPOTENT FIBROBLAST USING SAME

Номер: KR1020160056127A
Автор: LEE, SEUNG BUM, PARK, SUN HOO, KIM, MIN JUNG, SHIM, SE HWAN, LEE, SEUNG SOOK, SHIN, HYE YUN, LEE, SUN JU, JANG, WON SUK, JIN, YOUNG WOO
Принадлежит:

The present invention relates to a biomarker composition comprising CD105 for isolating multipotent fibroblast and a method for isolating multipotent fibroblast using the same. The present invention provides a CD105 antibody as a useful surface biomarker in confirming the selective isolation of multipotent fibroblast. According to the present invention, the fibroblast isolated from mouse hypodermal cells does not express CD73 and, based on the expression of markers specific to fibroblasts, is distinguished from mesenchymal stem cells. Also, CD105-positive and negative fibroblasts are isolated, based on a subculture-dependent decrease in the expression of a CD105 surface marker, and a comparative analysis of the capacities of multipotency revealed that the multipotency of the CD105-positive fibroblast was extremely high. Accordingly, CD105 of the present invention can be used in the development of the method for isolating fibroblasts with or without the capacity of multipotency. COPYRIGHT ...

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Номер записи: 19
11-09-2017 дата публикации

COMPOSITION FOR INHIBITING METASTASIS OF CANCER AND TREATING CANCER COMPRISING NPFFR2 INHIBITOR AS EFFECTIVE COMPONENT

Номер: KR101776864B1
Автор: SHIN, HYUN JIN, LEE, KEE HO, JUNG, WON HEE, SONG, JIE YOUNG, KIM, SU HYEON, LEE, EUN JU, HAN, CHUL JU, KIM, SANG BUM, PARK, SUN HOO, KIM, SUNG SUB, KIM, YEON SOO
Принадлежит: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES

The present invention relates to a pharmaceutical composition for inhibiting metastases of cancers comprising a neuropeptide FF receptor 2 (NPFFR2) inhibitor as an effective component; a method for inhibiting metastases of cancers comprising a step of administering the composition to a subject; a composition for diagnosing metastatic cancers comprising an agent for measuring the expression level of NPFFR2; a method for providing information for diagnosing metastatic cancers comprising a step of measuring the expression level of NPFFR2; and a screening method for an agent for inhibiting metastatic cancers. Additionally, the present invention relates to a pharmaceutical composition for preventing or treating cancers comprising an NPFFR2 inhibitor as an effective component. The compositions of the present invention comprising an NPFFR2 inhibitor inhibit metastases of cancers and induce apoptosis of cancer cells by suppressing abilities of cancer cells in terms of invasiveness, migration, colony ...

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Номер записи: 20
15-09-2017 дата публикации

OMR SHEET MARKING DEVICE

Номер: KR1020170104346A
Автор: PARK, SUN HOO
Принадлежит:

The present invention relates to an OMR sheet marking device. In the present invention, a marking process can be randomly performed on an OMR sheet at one time. To this end, a desired number of balls (50) are placed in a space formed between a first housing (10) and a second housing (20) so that the balls (50) are selectively received in a ball receiving hole (36′) of a ball plate (30). A stamp (40) protrudes to the outside of the second housing (20) by pressing the balls (50) received in the ball receiving hole (36′) so that the marking process is performed on the OMR sheet. Also, a fixing groove (170) for receiving a stationary magnet (172) is formed on the outer side of the first housing (10) so that at least one of specific numbers or information is selected and marked on the OMR sheet. According to the present invention, various types of marking processes can be conveniently performed on the OMR sheet. COPYRIGHT KIPO 2017 ...

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Номер записи: 21
07-03-2018 дата публикации

METHOD FOR EFFICIENT LONG-TERM CRYOPRESERVATION OF INTESTINE ORGANOID THROUGH COMPLEX TREATMENT OF INTESTINE ORGANOID STATE AND RHO-KINASE (ROCK) INHIBITOR ADDING TIME

Номер: KR1020180023640A
Автор: LEE, SEUNG BUM, PARK, SUN HOO, HAN, SUNG HOON, SHIM, SE HWAN, KIM, MIN JUNG, JANG, WON SUK, LEE, SUN JU, MYUNG, JAE KYUNG, LEE, SEUNG SOOK, JIN, YOUNG WOO
Принадлежит:

The present invention provides a method for efficient long-term cryopreservation of an intestine organoid through complex treatment of intestine organoid state and Rho-kinase (ROCK) inhibitor adding time. A method for long-term cryopreservation of an organoid of the present invention comprises the steps of: in vitro culturing the organoid; adding a culture medium having a ROCK (Rho-kinase) inhibitor included in the cultured intact undissociated organoid; and cryopreserving the culture medium-added organoid. The method according to the present invention has confirmed that survival rate is high when a cryopreserved in vitro cultured intestine organoid is thawed after cryopreserving the in vitro cultured intestine organoid in the form of an intact intestine organoid compared to a single cell. The method according to the present invention has confirmed that a method of directly adding the ROCK inhibitor to a freezing medium has a remarkably high survival recovery rate compared to a method of ...

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Номер записи: 22