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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 14. Отображено 14.
25-05-2018 дата публикации

OXYGEN GENERATING SCAFFOLD AND MANUFACTURING METHOD THEREOF

Номер: KR1020180054996A
Автор: AHN, CURIE, CHO, DONG WOO, LEE, EUN MI, JUNG, JI IN, YI, HEE GYEONG, ZAHID ALAM MD
Принадлежит:

The present invention relates to an oxygen generating scaffold including a polydimethyl siloxane (PDMS)-CaO2 ring structure and a polycaprolactone PCL film and a manufacturing method thereof. According to the present invention, the oxygen generating scaffold is capable of preventing a loss of the function of an islet cell, caused by the necrosis and apoptosis that occurs when oxygen is abnormally circulating due to islet encapsulation, and improving the survivability of islet and glucose-stimulated insulin secretion. Moreover, the present invention is capable of having a simple system and preventing an external obliteration of islet by injecting islet through a lateral surface, thereby having a low risk. As such, the scaffold is able to be widely applied in biomedical technology fields including the treatment of diabetes with a bioartificial islet. COPYRIGHT KIPO 2018 ...

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Номер записи: 1
26-07-2012 дата публикации

TRANSGENIC PIG EXPRESSING STNFR1-FC GENES AND THE USE THEREOF

Номер: WO2012099447A3
Автор: AHN, Cu Rie, LEE, Byeong Chun, HWANG, Jong Ik, YANG, Jae Seok, MOON, Byoung Gon, JANG, Goo, CHO, Bum Rae, KOO, Ok Jae, PARK, Sol Ji, KANG, Jung Taek, KWON, Dae Kee
Принадлежит:

The present invention relates to a transgenic pig secreting sTNFR1-Fc, which has inserted therein genes coding for sTNFR1-Fc having an extracellular region for the soluble tumor necrosis factor receptor (sTNFR1) which is fused to an Fc region of an immunoglobulin. The present invention also relates to a method for producing the transgenic pig, organs separated from the transgenic pig, a somatic cell donor cell line in which sTNFR1-Fc genes are inserted, a method for preparing blood including sTNFR1-Fc and to a method for preparing human sTNFR1-Fc from the blood of the transgenic pig. The transgenic pig may secrete substances for inhibiting TNF-α activity in blood, and thus may inhibit immune response and inflammation response, and therefore may be valuably used in heterotransplantation. In addition, the transgenic pig of the present invention has type O blood, and therefore may be transplanted for inhibiting an inflammatory response regardless of blood type.

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Номер записи: 2
07-07-2011 дата публикации

TRANSGENIC PIG IN WHICH HO-1 GENES AND TNFR1-FC GENES ARE SIMULTANEOUSLY EXPRESSED, AND METHOD FOR PRODUCING SAME

Номер: WO2011081343A3
Автор: AHN, Cu Rie, LEE, Byeong Chun, HWANG, Jong Ik, YANG, Jae Seok, JANG, Goo, CHO, Bum Rae, KOO, Ok Jae, KANG, Jung Taek, KWON, Dae Kee
Принадлежит:

The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fc fusion genes are simultaneously expressed. The present invention also relates to a transgenic pig for organ transplantation, which is produced by the method, and in which immune rejection response is inhibited. The present invention also relates to a somatic-cell-donating cell strain for producing the transgenic pig, and to a method for producing organs, from the transgenic pig, in which the immune rejection response is inhibited.

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Номер записи: 3
02-11-2018 дата публикации

신생돼지의 췌도 분리 방법

Номер: KR0101914837B1
Автор: 안규리, 이은미, 자히드 알람 엠디
Принадлежит: 서울대학교산학협력단

... 본 발명은 신생돼지로부터 췌도를 분리하는 방법에 관한 것으로, 구체적으로 (a) 신생돼지로부터 췌장을 적출하는 단계; (b) 적출한 췌장에 효소를 주입하는 단계로서, 상기 효소는 콜라게나아제 V인 단계; (c) 효소의 활성화를 유도하는 단계; 및 (d) 효소의 활성화로 유리된 췌도를 수집하는 단계를 포함하는 신생돼지의 췌도 분리 방법에 관한 것으로, 본 발명에 따른 췌도의 분리 방법을 이용하면 신생돼지로부터 높은 효율로 양질의 췌도를 분리해낼 수 있는바, 이종간 이식을 위한 췌도 분리 기술로서 활용할 수 있을 뿐만 아니라, 신생돼지 췌도의 분리와 배양 및 정도 분석 기술을 개발함으로써, 당뇨병 치료 등 생명의학 분야에서 널리 활용될 수 있다.

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Номер записи: 4
05-10-2018 дата публикации

산소 발생 스캐폴드 및 이의 제조방법

Номер: KR0101904613B1
Автор: 안규리, 조동우, 이은미, 정지인, 이희경, 자히드 알람 엠디
Принадлежит: 서울대학교산학협력단, 포항공과대학교 산학협력단

... 본 발명은 PDMS(폴리디메틸실록산)-CaO2 링 구조물 및 PCL(폴리카프로락톤) 막을 포함하는 산소 발생 스캐폴드 및 이의 제조방법에 관한 것으로, 본 발명에 따른 산소 발생 스캐폴드를 이용하면 췌도의 피막화로 인해 산소 공급이 원활하지 못해 발생하는 세포사멸 및 괴사로 췌도 세포의 기능이 상실되는 것을 극복할 수 있으며, 췌도의 생존율과 글루코스 자극에 대한 인슐린 분비 기능을 향상시킬 수 있다. 아울러, 시스템이 단순하며, 췌도를 옆면을 통해 주입함으로써 췌도의 외부 소실을 방지할 수 있어, 그 위험성이 비교적 낮다. 따라서, 바이오 인공 췌도를 이용한 당뇨병 치료 등 생명의학 기술 분야에서 널리 활용될 수 있다.

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Номер записи: 5
07-07-2011 дата публикации

TRANSGENIC PIG IN WHICH HO-1 GENES AND TNFR1-FC GENES ARE SIMULTANEOUSLY EXPRESSED, AND METHOD FOR PRODUCING SAME

Номер: KR2011081343A2
Автор: AHN, Cu Rie, LEE, Byeong Chun, HWANG, Jong Ik, YANG, Jae Seok, JANG, Goo, CHO, Bum Rae, KOO, Ok Jae, KANG, Jung Taek, KWON, Dae Kee
Принадлежит:

The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fc fusion genes are simultaneously expressed. The present invention also relates to a transgenic pig for organ transplantation, which is produced by the method, and in which immune rejection response is inhibited. The present invention also relates to a somatic-cell-donating cell strain for producing the transgenic pig, and to a method for producing organs, from the transgenic pig, in which the immune rejection response is inhibited.

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Номер записи: 6
18-05-2017 дата публикации

TRANSGENIC PIG WHICH SIMULTANEOUSLY EXPRESSES HO-1 GENE AND TNFR1-FC GENE, AND COMPRISES KNOCKED-OUT GGTA1 GENE, AND USE THEREOF

Номер: WO2017082667A1
Автор: LEE, Byeong Chun, AHN, Cu Rie, KIM, Geon A, YEOM, Su Cheong, KIM, Su Jin, CHO, Bum Rae, LEE, Eun Mi, LEE, Sang Hoon, HWANG, In Chang, HONG, Hye Jin
Принадлежит:

The present invention relates to a transgenic pig which simultaneously expresses a heme oxygenase-1 (HO-1) gene and a tumor necrosis factor receptor 1-Fc (TNFR1-Fc) gene and comprises a knocked-out α-1,3-galactosyltransferase (GGTA1) gene and in which an immune rejection response is inhibited upon xenotransplantation, and a method for preparing the same. The transgenic pig which simultaneously expresses human HO-1 and TNFR1-Fc fusion genes and comprises a knocked-out GGTA1 gene, according to the present invention, can reduce oxidative stress upon organ separation and in vitro culturing by the antioxidative action, cell protection functions, etc. of the HO-1 gene, can reduce a TNF-α mediated inflammatory response occurring during an initial transplant period by the expression of TNFR1-Fc, and also can inhibit maturation of dendritic cells and control the proliferation and activation of T-cells to reduce acute vascular rejection, thereby improving the initial engraftment of the transplanted ...

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Номер записи: 7
18-06-2018 дата публикации

METHOD FOR ISOLATING ISLET OF NEWBORN PIGLET

Номер: KR1020180065512A
Автор: AHN, CURIE, LEE, EUN MI, ZAHID ALAM MD
Принадлежит:

The present invention relates to a method for isolating an islet from a newborn piglet. Specifically, the present invention relates to a method for isolating an islet of a newborn piglet comprising the steps of: (a) extracting an islet from a newborn piglet; (b) injecting an enzyme into the extracted islet; and (c) inducing activation of the enzyme. The method can be used not only as an islet isolation technique for transplantation, but also widely in a biomedical field such as treatment of diabetes by developing a technology for isolating, culturing and analyzing islets of the newborn piglet. COPYRIGHT KIPO 2018 ...

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Номер записи: 8
24-05-2017 дата публикации

TRANSGENIC PIG SIMULTANEOUSLY EXPRESSING HO-1 GENE AND TNFR1-Fc GENE AND HAVING GGTA1 GENE KNOCKED OUT, AND USE THEREOF

Номер: KR1020170056796A
Автор: LEE, BYEONG CHUN, AHN, CU RIE, KIM, GEON A, YEOM, SU CHEONG, KIM, SU JIN, CHO, BUM RAE, LEE, EUN MI, LEE, SANG HOON, HWANG, IN CHANG, HONG, HYE JIN
Принадлежит:

The present invention relates to a transgenic pig and a method for producing the same wherein the transgenic pig simultaneously expresses heme oxygenase-1 (HO-1) gene and tumor necrosis factor receptor 1-Fc (TNFR1-Fc) gene, and GGTA1 (α-1,3-galactosyltransferase) gene is knocked out, immune rejection reaction is suppressed when a heterogeneous organ is transplanted. The transgenic pig, which simultaneously expresses human HO-1 and TNFR1-Fc fusion gene and has GGTA1 gene knocked out, of the present invention can have reduced stress during separation of an organ and culture in vitro by an anti-oxidation effect, a cell protection function of HO-1 gene. An inflammatory reaction, mediated by TNF-α and occurring in an early phase of transplantation, can be reduced by expression of TNFR1-Fc. In addition, early phase engraftment of the transplanted organ can be promoted by reducing acute vascular system rejection by inhibiting maturity of dendritic cells, and adjusting growth and activity of T ...

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Номер записи: 9
03-12-2009 дата публикации

CD70-EXPRESSING NEURAL STEM CELLS CAPABLE OF INHIBITING TRANSPLANT IMMUNE RESPONSES AND USE THEREOF

Номер: WO2009145434A3
Автор: AHN, Cu Rie, LEE, Eun Mi, KIM, Jae Young
Принадлежит:

The present invention relates to a composition for inhibiting immune responses to transplanted internal organs, tissues or cells including CD70-expressing neural stem cells, and a method for inhibiting immune responses of individuals using the composition.

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Номер записи: 10
24-05-2018 дата публикации

OXYGEN-GENERATING SCAFFOLD AND METHOD FOR PRODUCING SAME

Номер: WO2018092962A1
Автор: AHN, Curie, CHO, Dong-Woo, LEE, Eun Mi, JUNG, Ji-in, YI, Hee-Gyeong, ZAHID, Alam Md
Принадлежит:

The present invention relates to an oxygen-generating scaffold comprising a polydimethylsiloxane (PDMS)-CaO2 ring structure and a polycaprolactone (PCL) membrane and a method of producing the same. Using the oxygen-generating scaffold according to the present invention makes it possible to overcome the loss of function of islet cells due to apoptosis and necrosis that are caused by insufficient oxygen supply due to encapsulation of islets, and to enhance the survival rate of islets and insulin secretion function with respect to glucose stimulation. In addition, the system is simple, and the risks are relatively low since the external loss of islets can be prevented by injecting the islets through a side thereof. Therefore, the present invention can be widely used in biomedical technology fields such as diabetes treatment using bioartificial islets.

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Номер записи: 11
26-07-2012 дата публикации

TRANSGENIC PIG EXPRESSING STNFR1-FC GENES AND THE USE THEREOF

Номер: WO2012099447A2
Автор: AHN, Cu Rie, LEE, Byeong Chun, HWANG, Jong Ik, YANG, Jae Seok, MOON, Byoung Gon, JANG, Goo, CHO, Bum Rae, KOO, Ok Jae, PARK, Sol Ji, KANG, Jung Taek, KWON, Dae Kee
Принадлежит:

The present invention relates to a transgenic pig secreting sTNFR1-Fc, which has inserted therein genes coding for sTNFR1-Fc having an extracellular region for the soluble tumor necrosis factor receptor (sTNFR1) which is fused to an Fc region of an immunoglobulin. The present invention also relates to a method for producing the transgenic pig, organs separated from the transgenic pig, a somatic cell donor cell line in which sTNFR1-Fc genes are inserted, a method for preparing blood including sTNFR1-Fc and to a method for preparing human sTNFR1-Fc from the blood of the transgenic pig. The transgenic pig may secrete substances for inhibiting TNF-α activity in blood, and thus may inhibit immune response and inflammation response, and therefore may be valuably used in heterotransplantation. In addition, the transgenic pig of the present invention has type O blood, and therefore may be transplanted for inhibiting an inflammatory response regardless of blood type.

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Номер записи: 12
14-06-2018 дата публикации

METHOD FOR ISOLATING ISLET OF NEWBORN PIG

Номер: WO2018105805A1
Автор: AHN, Curie, LEE, Eun Mi, ZAHID, Alam Md
Принадлежит:

The present invention relates to a method for isolating an islet from a newborn pig and, specifically, to a method for isolating an islet of a newborn pig, the method comprising the steps of: (a) extracting an islet from a newborn pig; (b) injecting an enzyme into an extracted pancreas; and (c) inducing the activation of the enzyme. The use of the method for isolating an islet according to the present invention can isolate a high-quality islet from a newborn pig at high efficiency, and thus can lead to not only the utilization as an islet isolation technique for xenotransplantation but also the development of techniques for isolation, culture, and quality analysis of an islet of a newborn pig, and therefore, the method according to the present invention can be widely utilized in the biomedical field, such as diabetes treatment.

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Номер записи: 13
29-11-2016 дата публикации

배아 줄기 세포주 및 이의 제조방법

Номер: KR0101680269B1
Автор: 노성일, 황우석, 이병천, 강성근, 류영준, 이유진, 김순웅, 권대기, 권희선, 구자민, 박을순, 황윤영, 문신용, 오선경, 안규리, 윤현수, 박종혁, 김선종, 최양규
Принадлежит: 주식회사 에이치바이온

... 인간의 체세포 핵을 탈핵된 인간 난자에 이식함으로써 제조된 핵이식란으로부터 유래된 배아 줄기 세포주는 다양한 원하는 세포 유형으로 분화될 수 있다.

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Номер записи: 14