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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 64. Отображено 64.
08-07-2016 дата публикации

STRONG MAGNETIC WATER APPARATUS FOR GENERATING MAGNETIZED WATER AND METHOD OF GENERATING MAGNETIZED WATER

Номер: KR1020160080683A
Автор: AN, JONG SUK
Принадлежит:

The present invention relates to a faucet socket generating magnetized water with a strong magnetic force and a method of generating the strong magnetic force. The present invention is configured to double a magnetic force of a neodymium magnet (200) by making the size of a central fine penetrating hole (301) of the faucet socket (320) to be smaller horizontally as a rare earth magnet has a characteristic of having a strong magnetic force when end sections of both poles are narrower and a magnetic force dispersed when the size thereof is relatively large. Accordingly, as it is shown in figure 3, one group as a unit is configured to generate the strong magnetic force. The present invention has effects of: exhibiting an excellent cleaning capability of water; and enhancing the growth of plants as water passes through the strong magnetic force generated symmetrically around the fine penetration hole and is changed into a different state of water. COPYRIGHT KIPO 2016 ...

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16-01-2023 дата публикации

신규 메틸설폰아미드 유도체 화합물의 암전이 억제용 조성물

Номер: KR20230008908A
Принадлежит:

... 본 발명은 메틸설폰아미드계 유도체 화합물을 유효성분으로 함유하는 암전이 억제용 조성물에 관한 것이다. 보다 구체적으로, 본 발명의 화합물들이 CSE1L(chromosome segregation 1-like) 활성을 저해하고, 세포내 핵수송 기능을 억제함으로써 암세포의 이동 및/또는 침윤을 억제하여 암전이를 효과적으로 억제한다.

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16-01-2019 дата публикации

유전체 도파관 필터

Номер: KR0101939056B1
Автор: 안종석
Принадлежит: 안종석

... 유전체 도파관 필터가 개시된다. 본 발명의 일실시예의 필터는, 세라믹 재질로서, 그 표면에 도전성 재질이 도포되고, 각각 사이에 형성되는 상부 및 하부의 제1 및 제2슬랏에 의해 구획되는 복수의 제1공진기블럭; 및 세라믹 재질로서, 그 표면에 도전성 재질이 도포되고, 상기 복수의 제1공진기 블럭 중 하나인 제3공진기블럭의 상부에 배치되는 제2공진기블럭을 포함하고, 상기 제3공진기블럭의 상면에는 상기 도전성 재질이 제거된 제1윈도우가 형성되고, 상기 제2공진기블럭의 상면에 상기 제1윈도우에 대응하는 위치에 상기 도전성 재질이 제거된 제2윈도우가 형성되어, 제1커플러를 형성한다.

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28-04-2011 дата публикации

WIRELESS COMMUNICATION SYSTEM AND METHOD

Номер: KR2011049250A1
Принадлежит:

The present invention relates to a wireless communication system based on IEEE 802.15.4 and its method. The wireless communication system of the present invention comprises a coordinator and a plurality of sensor nodes connected to the coordinator. The coordinator, which is one of the plurality of sensor nodes, synchronizes the plurality of sensor nodes and controls transmission and receiving of data, and the sensor nodes are connected to a wireless personal area network to transmit and receive data. Among two queues implemented in the sensor node, one queue where a GTS request frame is to be stored has priority over the other. When the GTS request frame is stored, the GTS request frame is sent to the coordinator before other general data frames. In another aspect, the wireless communication system based on IEEE 802.15.4 according to the present invention comprises a coordinator and a plurality of sensor nodes connected to the coordinator. The coordinator broadcasts assignment information ...

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23-11-2016 дата публикации

CURRENT AMPLIFYING WINDING DEVICE AND CIRCUIT OF GENERATOR APPLYING BIPOLAR PARALLEL MOTION LAW

Номер: KR1020160134160A
Автор: AN, JONG SUK
Принадлежит:

The present invention relates to a current amplifying winding device and a circuit of a generator applying a bipolar parallel motion law, and more specifically, to a current amplifying winding device and a circuit of a generator applying a bipolar parallel motion law which change the times of winding coils or the thickness of coils to generate higher currents in a generator using a permanent magnet which rotates along the circumference corresponding to a ferrite core where coils are winded. According to the present invention, the level of currents generated in a generator is greatly increased, such that a small device can generate a high power and power generation having the same efficiency with a power generating apparatus using a superconductor in a cryogenic circumstance is possible. COPYRIGHT KIPO 2016 ...

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07-02-2023 дата публикации

환자에 대한 해석가능한 예측 결과를 생성하는 방법 및 시스템

Номер: KR20230018929A
Автор: 안종석, 이정훈
Принадлежит:

... 본 개시는 적어도 하나의 컴퓨팅 장치에 의해 수행되는, 환자에 대한 해석가능한 예측 결과를 생성하는 방법에 관한 것이다. 이 방법은, 대상 환자의 의료 이미지 데이터를 수신하는 단계, 대상 환자의 추가 의료 데이터를 수신하는 단계 및 기계학습 예측 모델을 이용하여, 대상 환자의 의료 이미지 데이터 및 대상 환자의 추가 의료 데이터를 기초로, 대상 환자에 대한 예측 결과에 대한 정보를 생성하는 단계를 포함한다.

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13-06-2013 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC DISEASES, COMPRISING NYMPHAEA TETRAGONA ROOT EXTRACT, FRACTIONS THEREOF, OR POLYPHENOL-BASED COMPOUNDS ISOLATED FROM THE NYMPHAEA TETRAGONA ROOT EXTRACT AS ACTIVE INGREDIENTS

Номер: WO2013085338A3
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing and treating metabolic diseases, comprising nymphaea tetragona root extract, fractions thereof, or polyphenol-based compounds isolated from the nymphaea tetragona root extract. The nymphaea tetragona root extract and fractions thereof effectively inhibit the activity of glycerol-3-phosphate (GPAT), which may cause metabolic diseases, and exhibit inhibitory activity against the biosynthesis of neutral fats in cells and increased insulin-dependent glucose uptake activity in skeletal muscle cells. Thus, nymphaea tetragona root extract, fractions thereof, or polyphenol-based compounds isolated from the nymphaea tetragona root extract can be effectively used in the prevention and treatment of metabolic diseases such as obesity, type 2 diabetes, dyslipidemia, insulin resistance, hepatic steatosis, and non-alcoholic fatty liver disease.

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24-01-2018 дата публикации

끈이 결합된 통기성 지퍼

Номер: KR0101821854B1
Автор: 안종석
Принадлежит: 안종석

... 본 발명은 끈이 결합된 통기성 지퍼에 관한 것으로 의류 또는 신발 등을 착용자의 체형에 따라 길이 조절이 가능하되, 착용감을 극대화시킬 수 있도록 통기성을 부여함과 아울러, 착용자 개인의 개성 연출이 가능하고, 보다 신속·간편하게 착탈이 가능하도록 하기 위하여, 절개부가 형성되도록 양측에 마주하게 구비되는 각 외피에 적어도 하나 이상의 끈의 일단이 길이 조절가능하게 연결되고, 상기 끈의 타단은 양측 외피 사이에 구비되는 지퍼부재의 지퍼띠에 연결되어, 지퍼띠와 적어도 하나 이상의 끈 사이에 통기공이 형성되도록 하고, 상기 외피에 연결된 끈의 길이를 조절고정한 상태에서 지퍼슬라이드의 조작으로 개폐 조절 가능하도록 구성되는 것을 포함하여 이루어진다.

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08-05-2018 дата публикации

NOVEL MACROLIDE-BASED COMPOUND, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MALARIA CONTAINING SAME

Номер: KR1020180046357A
Принадлежит:

The present invention relates to a novel macrolide-based compound, a preparation method thereof, and a pharmaceutical composition for preventing or treating malaria containing the same. The macrolide-based compound represented by chemical formula 1 according to the present invention exhibits an effective antigenic activity against Plasmodium sp., and thereby can be useful for the prevention or treatment of malaria. COPYRIGHT KIPO 2018 ...

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13-06-2013 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC DISEASES, COMPRISING NYMPHAEA TETRAGONA ROOT EXTRACT, FRACTIONS THEREOF, OR POLYPHENOL-BASED COMPOUNDS ISOLATED FROM THE NYMPHAEA TETRAGONA ROOT EXTRACT AS ACTIVE INGREDIENTS

Номер: WO2013085338A2
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing and treating metabolic diseases, comprising nymphaea tetragona root extract, fractions thereof, or polyphenol-based compounds isolated from the nymphaea tetragona root extract. The nymphaea tetragona root extract and fractions thereof effectively inhibit the activity of glycerol-3-phosphate (GPAT), which may cause metabolic diseases, and exhibit inhibitory activity against the biosynthesis of neutral fats in cells and increased insulin-dependent glucose uptake activity in skeletal muscle cells. Thus, nymphaea tetragona root extract, fractions thereof, or polyphenol-based compounds isolated from the nymphaea tetragona root extract can be effectively used in the prevention and treatment of metabolic diseases such as obesity, type 2 diabetes, dyslipidemia, insulin resistance, hepatic steatosis, and non-alcoholic fatty liver disease.

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20-05-2010 дата публикации

PHARMACEUTICAL COMPOSITION FOR SUPPRESSING DNA METHYLTRANSFERASE, CONTAINING ARYLOXYACETYL-BASED COMPOUNDS AS ACTIVE INGREDIENTS

Номер: WO2010056048A3
Принадлежит:

The present invention relates to a pharmaceutical composition for suppressing DNA methyltransferase, containing the aryloxyacetyl-based compounds expressed in chemical formula 1 as active ingredients. The composition of the present invention can be used as a therapeutic agent for tumors, neurological brain diseases, hematologic diseases, and epigenetic diseases caused by DNA hypermethylation. Further, the present invention provides uses of aryloxyacetyl-based compounds expressed in chemical formula (1) mentioned below or pharmaceutically acceptable salts thereof to produce a DNA methyltransferase inhibitor or a DNA methylation inhibitor. The present invention provides a method for treating diseases caused by DNA hypermethylation by administering aryloxyacetyl-based compounds (LW6) expressed in chemical formula 1, or pharmaceutically acceptable salts thereof, to mammals (including humans) that require DNA methytransferase inhibition or DNA methylation inhibition.

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27-10-2016 дата публикации

IONIZED WATER GENERATING DEVICE

Номер: WO2016171409A1
Автор: AN, Jong Seok
Принадлежит:

The present invention relates to an ionized water generating device, and the purpose of the present invention is to develop an ionized water generating device, which causes water to flow between permanent magnets, thereby ionizing the same, and which has a high ionization efficiency while guaranteeing easy fabrication and assembly. Particularly, the present invention relates to an ionized water generating device configured such that, when water flows in through one side thereof, the same vertically penetrates between permanent magnets, which are contained therein, and which have different polarities, and is ionized with no discharge phenomenon occurring, the ionized water generating device comprising: a lower connection portion, which has a thread formed on the inner peripheral surface thereof, and which has a first O-ring insertion groove formed thereon; an upper connection portion, which has a thread formed thereon, and which has a second O-ring insertion groove formed thereon; a housing ...

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02-07-2018 дата публикации

MACHINE MANAGING DEVICE AND IOT MANAGING DEVICE HAVING CONTAINER MANAGING COMPONENT

Номер: KR1020180072891A
Принадлежит:

The present invention is to provide a machine managing device and an internet of things (IoT) managing device having a container managing component. In a physical machine of a virtual machine in which a plurality of containers are driven or a physical machine in which a plurality of containers are driven, the machine managing device comprises: a meta information storage storing meta information of the physical machine; a monitoring component monitoring a resource status of the physical machine; and a container managing component managing the container based on metadata and resource status information of the physical machine. COPYRIGHT KIPO 2018 (110,120) Physical machine (210) Virtual machine (301,302,303) Container (410) Manager server (500) Machine managing device (510) Meta information storage (520) Monitoring component (530) Container managing component (540) Resource report component (550) Topology report component ...

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17-12-2015 дата публикации

METHOD FOR DETECTING FILAGGRIN GENE MUTATION FOR DIAGNOSING ATOPIC DERMATITIS

Номер: WO2015190655A1
Принадлежит:

The present invention relates to a probe complementarily binding to a filaggrin gene mutation nucleic acid sequence, and a method for detecting a filaggrin gene mutation using the same. Specifically, by preparing a PNA probe complementarily binding to a filaggrin gene and employing fluorescence melting curve analysis (FMCA) using a difference in binding strength between a normal type and a mutation type to provide the convenience of being able to determine a filaggrin gene mutation simply, promptly, and accurately, aetiological factors of atopic dermatitis patients can be diagnosed, and especially, the likelihood of atopic dermatitis during infancy immediately after birth can be promptly diagnosed, thereby decreasing the disease rate.

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03-05-2018 дата публикации

NOVEL MACROLIDE-BASED COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MALARIA AND CONTAINING SAME AS ACTIVE INGREDIENT

Номер: WO2018080072A2
Принадлежит:

The present invention relates to a novel macrolide-based compound, a method for producing the same, and a pharmaceutical composition, which is for preventing or treating malaria and contains the novel macrolide-based compound as an active ingredient. The macrolide-based compound represented by chemical formula 1 according to the present invention effectively exhibits an antiprotozoal activity against Plasmodium sp. protozoan, and thus can be usefully used to prevent or treat malaria.

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03-09-2020 дата публикации

COMPOSITION COMPRISING COLCHICINE FOR TREATING ALLERGIC SKIN DISEASE OR PRURITUS CUTANEOUS

Номер: WO2020175865A1
Принадлежит:

The present invention relates to a composition comprising colchicine. The composition according to the present invention enhances the expression amount of filaggrin that is highly related to the onset of allergic skin diseases, enhances skin moisturizing effects to thereby improve the skin barrier function, and in addition, controls inflammatory responses by allergic skin diseases, thereby showing excellent effects in the prevention and treatment of allergic skin diseases and/or pruritus cutaneous and skin moisturization and skin condition improvement.

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10-11-2016 дата публикации

AIR-PERMEABLE ZIPPER COMBINED WITH STRAP

Номер: KR1020160130124A
Автор: AN, JONG SEOK
Принадлежит:

The present invention relates to an air-permeable zipper combined with a strap. According to the present invention, length adjustment can be performed on clothes, shoes, and the like in accordance with the body shape of a wearer and air permeability can be provided for wearing comfort maximization. In addition, the wearer is allowed to express individuality and putting on and off can be facilitated and expedited. According to the present invention, one end of at least one strap is connected to be capable of length adjustment to each of outer skins provided to face each other on both sides for cut portion formation. The other end of the strap is connected to a zipper strap of a zipper member provided between the outer skins on both sides. A vent hole is formed between the zipper strap and the one or more straps. Opening and closing control can be performed based on a zipper slide operation in a state where the length of the strap connected to the outer skin is adjusted and fixed. COPYRIGHT ...

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11-11-2015 дата публикации

device for inspecting an welding part

Номер: KR0101568127B1
Автор: 이성식, 안종석, 박진근
Принадлежит: 세이프텍(주)

... 본 발명은 잘못된 재료의 용접봉에 대한 사용 여부를 정확히 확인할 수 있도록 한 새로운 형태에 따른 보일러 튜브의 용접부위 검사장치 및 이를 이용한 검사방법에 관한 것이다. 이를 위해, 본 발명은 보일러 튜브의 용접 부위에 대한 자기장 변화를 감지하여 이를 디지털값으로 변환하여 제공하는 탐지 프로브; 상기 탐지 프로브로부터 제공받은 디지털값을 투자율로 변환하여 제공하는 변환프로그램을 가지고, 상기 탐지 프로브에 의한 각 검사 횟수별 투자율을 토대로 평균 투자율을 확인하며, 이 평균 투자율을 근거로 한 비권장 용접봉의 사용 여부에 대한 판단 및 비권장 용접봉의 사용 부위에 대한 판단을 수행하도록 프로그래밍된 컨트롤러; 그리고, 상기 컨트롤러에 의해 제공된 탐지 프로브의 검사 횟수별 투자율을 그래프화하여 디스플레이하고, 상기 컨트롤러에 의해 판단된 결과 정보를 디스플레이하는 디스플레이부;를 포함하여 구성됨을 특징으로 하는 보일러 튜브의 용접부위 검사장치가 제공된다.

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20-05-2010 дата публикации

PHARMACEUTICAL COMPOSITION FOR SUPPRESSING DNA METHYLTRANSFERASE, CONTAINING ARYLOXYACETYL-BASED COMPOUNDS AS ACTIVE INGREDIENTS

Номер: WO2010056048A2
Принадлежит:

The present invention relates to a pharmaceutical composition for suppressing DNA methyltransferase, containing the aryloxyacetyl-based compounds expressed in chemical formula 1 as active ingredients. The composition of the present invention can be used as a therapeutic agent for tumors, neurological brain diseases, hematologic diseases, and epigenetic diseases caused by DNA hypermethylation. Further, the present invention provides uses of aryloxyacetyl-based compounds expressed in chemical formula (1) mentioned below or pharmaceutically acceptable salts thereof to produce a DNA methyltransferase inhibitor or a DNA methylation inhibitor. The present invention provides a method for treating diseases caused by DNA hypermethylation by administering aryloxyacetyl-based compounds (LW6) expressed in chemical formula 1, or pharmaceutically acceptable salts thereof, to mammals (including humans) that require DNA methytransferase inhibition or DNA methylation inhibition.

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08-03-2018 дата публикации

METHOD FOR MANAGING ATTENDANCE, AND APPARATUS AND SYSTEM FOR EXECUTING SAME

Номер: KR101835425B1

Disclosed are a method for managing an attendance and an apparatus and system for executing the same. The method for managing an attendance according to an exemplary embodiment of the present invention includes an administrator terminal which broadcasts an attendance confirmation request in a classroom, receives an attendance response signal in response to the attendance confirmation request, and performs attendance processing based on the received attendance response signal, and a student terminal which generates distance information between the nearest student terminals by measuring a distance between neighboring student terminals and transmits the attendance response signal including terminal identification information of the corresponding student terminal and the generated distance information between the nearest student terminals. Accordingly, the present invention can check a proxy attendance. COPYRIGHT KIPO 2018 (AA) Start (BB) End (S101) Request student information to the attendance ...

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30-11-2018 дата публикации

DIELECTRIC WAVEGUIDE FILTER

Номер: KR1020180127793A
Автор: AHN, JONG SEOK
Принадлежит:

Disclosed is a dielectric waveguide filter stably operating even at high output. According to one embodiment of the present invention, the filter comprises: a plurality of first resonator blocks made of a ceramic, respectively having a surface coated with a conductive material, and partitioned by upper and lower first and second slots formed between the first resonator blocks; and a second resonator block made of a ceramic, having a surface coated with a conductive material, and disposed on a third resonator block of the first resonator blocks. A first window in which the conductive material is removed is formed on an upper surface of the third resonator block and a second window in which the conductive material is removed is formed on an upper surface of the second resonator at a position corresponding to the first window, so that a first coupler is formed. COPYRIGHT KIPO 2019 ...

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19-06-2015 дата публикации

COMPOSITION CONTAINING AJOENE FOR PREVENTING OR TREATING TUBERCULOSIS

Номер: KR1020150068186A
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, which contains ajoene as an active ingredient. According to the present invention, ajoene, if applied to a cell which is infected with Mycobacterium tuberculosis, is able to induce phosphorylation of CHOP, Bip/GRP78 and eIF2α or to induce an endoplasmic reticulum stress by increasing active oxygen. The increased endoplasmic reticulum stress can induce an apoptosis of infected cells, thereby inhibiting the growth of Mycobacterium tuberculosis. Accordingly, an ajoene compound of the present invention can be used as a more effective therapeutic agent for treating tuberculosis. COPYRIGHT KIPO 2015 ...

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14-07-2016 дата публикации

NOVEL CYCLIC DEPSIPEPTIDE-BASED COMPOUND, METHOD FOR PREPARING SAME, AND ANTIBACTERIAL PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

Номер: WO2016111574A1
Принадлежит:

The present invention relates to a novel cyclic depsipeptide-based compound, a method for preparing same, and an antibacterial pharmaceutical composition containing same as an active ingredient, the novel cyclic depsipeptide-based compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, exhibiting inhibitory activity against Staphylococcus aureus and Salmonella typhimurium, thereby being able to be usefully employed for an antibacterial composition, antibacterial pharmaceutical composition, antibacterial feed composition, or antibacterial cosmetic composition, and for the treatment of bacterial infectious diseases.

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21-03-2016 дата публикации

Vaccum motor with generator

Номер: KR0101604637B1
Автор: 안종석
Принадлежит: 안종석

... 본 발명은 양극평형운동을 이용한 시간차 발전기가 부착된 진공 전동기에 관한 것으로 특히, 냄비 형상의 하부 캡과 뚜껑 형상의 상부 캡으로 이루어진 진공상태의 케이스와; 상기 케이스 중 하부 캡의 중심부에 형성된 안치홈 내에 수직방향으로 고정 설치되어 구동모터에 전원 전압의 공급되면 복수의 페라이트 코어에 각각 권취된 권선코일에서 서로 다른 시간차를 두고 각각 독립적으로 발전전압을 발생하는 발전기와; 복수의 휠 구동용 코어와 플라이 휠 및 복수의 휠 구동용 영구자석이 상기 케이스 내에 고정 및 회동 가능하게 설치되고, 외부 회전축 결합용 캡 및 외부 회전축은 상기 케이스 중 상부 캡의 중심점에서 상방향을 향해 돌출 형성된 축 가이더의 외부에서 회동 가능하게 설치된 형태를 갖고 상기 발전기에서 발전되는 전압에 대응하는 회전수를 갖고 플라이 휠과 외부 회전축이 회전하며 상기 외부 회전축에 연결되는 부하의 구동에 필요한 동력을 발생시켜 주는 전동기;로 구성한 것을 특징으로 한다. 따라서, 전동기에서 발생하는 열을 최소화할 수 있어 발전기의 발전효율 및 전동기의 구동효율을 대폭 향상시킬 수 있으며, 또한 발전기 및 전동기가 구동될 때 공기와의 마찰력을 포함하여 기압 등으로 인한 저항을 최소화할 수 있고, 또 적은 소비전력을 갖는 발전기에서 발전되는 전압을 이용하여 부하 구동용 전동기를 구동시켜 강력한 회전 에너지를 얻을 수 있으므로 발전기의 소비전력 대비 큰 회전 에너지를 얻을 수 있어 에너지 절감효과를 얻을 수 있다.

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08-08-2019 дата публикации

ANTI-INFLAMMATORY COMPOSITION COMPRISING ACYLHYDRAZONE DERIVATIVE

Номер: WO2019151676A1
Принадлежит:

The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. An acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention can be effectively used for the prevention, alleviation or treatment of inflammatory diseases.

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03-11-2015 дата публикации

Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-b]furan-2-carbohydrazide derivatives as an active ingredient

Номер: KR0101565430B1
Принадлежит: 한국생명공학연구원

... 본 발명은 신규한 세포 유사분열 저해제인 N-메틸렌나프토[2,1-b]퓨란-2-카보하이드라지드 유도체에 관한 것이다. N-메틸렌나프토[2,1-b]퓨란-2-카보하이드라지드 유도체는 유사분열 과정에서 튜불린의 중합을 저해하여 세포자살을 유도한다. 또한 다제약 내성을 보이는 암세포에도 효과가 우수하다. 따라서 다양한 암을 비롯한 세포증식성 질병의 치료에 중요하게 이용될 수 있다.

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22-10-2018 дата публикации

SKIN WHITENING COMPOSITION CONTAINING FUSARISETIN COMPOUND

Номер: KR101910507B1

The present invention relates to a cosmetic composition containing a fusarisetin compound, a stereoisomer thereof, or a salt thereof as an active ingredient. The present invention further relates to a pharmaceutical composition or a food composition. The fusarisetin compound contained in the composition of the present invention inhibits melanin biosynthesis and also suppresses expression of tyrosinase-related protein-1 (Trp-1) or tyrosinase. Accordingly, the composition containing the fusarisetin compound can be used for skin whitening or for preventing, improving, or treating pigmentation. COPYRIGHT KIPO 2018 ...

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29-08-2017 дата публикации

NOVEL INDOLE DERIVATIVES AND ANTICANCER COMPOSITION COMPRISING SAME

Номер: KR1020170098170A
Принадлежит:

The present invention relates to indole derivatives as novel mitotic inhibitors, stereoisomers thereof, or pharmaceutically acceptable salts thereof, uses of the same for therapeutic drugs, a composition comprising the same, a treatment method using the composition, and a production method of the same. The indole derivatives, stereoisomers thereof, or pharmaceutically acceptable salts thereof inhibit tubulin polymerization during mitosis, induce apoptosis, and show excellent anticancer effects even to multidrug resistant cancer cells. COPYRIGHT KIPO 2017 ...

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19-06-2018 дата публикации

APPARATUS FOR DETERMINING MEANS OF TRANSPORTATION AND METHOD THEREOF

Номер: KR1020180066725A
Принадлежит:

Disclosed are an apparatus for accurately determining a means of transportation of a user and a method thereof. According to an embodiment of the present invention, the apparatus for determining a means of transportation comprises: a step number measuring unit for measuring the number of steps per unit time of the user; a position information obtaining unit for obtaining position information of the user according to a set cycle; and a transportation means determining unit for determining a means of transportation of the user by comparing the moving speed on the bottom surface corresponding to the measured number of steps of the user with the moving speed calculated by a change in the position information of the user. COPYRIGHT KIPO 2018 (102) Step number measuring unit (104) Position information obtaining unit (106) Transportation means determining unit ...

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22-09-2022 дата публикации

신규 이중환형 화합물, 이의 광학 이성질체 또는 이의 약학적으로 허용가능한 염, 이의 용도 및 이의 제조방법

Номер: KR20220128953A
Принадлежит:

... 본 발명은 화학식 1로 표시되는 화합물, 이의 광학 이성질체, 또는 이의 약학적으로 허용가능한 염과 이를 포함하는 Wnt/β-catenin 신호전달 관련 질환 예방 또는 치료용 약학적 조성물을 제공한다.

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26-01-2012 дата публикации

NOVEL FUSARISETIN COMPOUNDS, AND USE THEREOF

Номер: WO2012011741A3
Принадлежит:

The present invention relates to novel fusarisetin compounds separated from Fusarium sp. FN080326 and having an anticancer activity, and to the use thereof. In detail, novel fusarisetin compounds separated and purified from Fusarium sp. FN080326, which is in turn separated from a soil sample, have an inhibitory activity on the proliferation and transfer of cancer cells such as breast-cancer cells, liver-cancer cells or myeloid-leukemic cells. Therefore, the compounds can be effectively used for anticancer compositions containing the compounds as active ingredients.

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11-12-2015 дата публикации

IONIC WATER GENERATOR

Номер: KR101576863B1
Автор: AN, JONG SEOK
Принадлежит: GEMMAGREEN

The present invention relates to an ionic water generator ionizing water by allowing the water to vertically penetrate between embedded permanent magnets with different polarities when the water flows into one side of the ionic water generator. The ionic water generator comprises a lower connection part; an upper connection part; a housing including a main partition, two pairs of reinforcing ribs, left and right reinforcing ribs, two magnet insertion holes, and one or more horizontal reinforcing rib; a metal pipe; and an upper finishing cap. The lower part of the housing is integrated with the upper part of the lower connection part for making a flow path extend through the lower part, and integrated with the lower part of the upper connection part for making the flow path extend through the upper part. A second coupling part, a fourth O-ring insertion groove, and a through hole are formed on the upper surface of the lower connection part. COPYRIGHT KIPO 2016 ...

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12-01-2016 дата публикации

A NOVEL TUBULIN POLYMERIZATION INHIBITOR, AND THE SYNTHESIZING METHOD THEREOF

Номер: KR0101584731B1
Принадлежит: 한국생명공학연구원

... 본 발명은 신규의 튜불린 중합 저해제로서 (E)-에틸 2-(2-메틸-3-((2-(나프토[2,1-b]퓨란-2-카보닐)히드라조노)메틸)-1H-인돌-1-일)아세테이트((e)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1h-indol-1-yl)acetate), 및 그 합성방법에 관한 것이다. 본 발명의 화합물에 의하면, 튜불린에 결합하여 미세소관 중합을 저해함으로써 세포 유사분열을 억제 및 세포사멸을 유도할 수 있기 때문에 항암제로 이용할 수 있다. 본 발명의 합성방법에 의하면, 반응이 간결하고 효율이 60% 이상으로 수율이 매우 높기 때문에, 효과적인 합성방법을 제공할 수 있다.

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31-05-2017 дата публикации

DEVICE AND METHOD FOR DETERMINING EFFECTIVENESS OF FINE DUST MEASUREMENT DATA

Номер: KR101741630B1
Автор: AHN, JONG SUK

The present invention relates to determination of effectiveness of sensor data and, more particularly, to a device and a method for determining the effectiveness of fine dust measurement data for verifying effectiveness of data input from a find dust measurement sensor. The device comprises: a data receiving unit for receiving fine dust measurement data sensed from the fine dust measurement sensor; a data effectiveness determination unit for determining the effectiveness of the received fine dust measurement data; and an error determination output unit for outputting an error determination result. COPYRIGHT KIPO 2017 ...

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26-01-2012 дата публикации

NOVEL FUSARISETIN COMPOUNDS, AND USE THEREOF

Номер: WO2012011741A2
Принадлежит:

The present invention relates to novel fusarisetin compounds separated from Fusarium sp. FN080326 and having an anticancer activity, and to the use thereof. In detail, novel fusarisetin compounds separated and purified from Fusarium sp. FN080326, which is in turn separated from a soil sample, have an inhibitory activity on the proliferation and transfer of cancer cells such as breast-cancer cells, liver-cancer cells or myeloid-leukemic cells. Therefore, the compounds can be effectively used for anticancer compositions containing the compounds as active ingredients.

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11-04-2019 дата публикации

SKIN WHITENING COMPOSITION CONTAINING FUSARISETIN COMPOUND

Номер: WO2019070087A1
Принадлежит:

The present invention provides a cosmetic composition, a pharmaceutical composition, or a food composition, each containing a fusarisetin compound, a stereoisomer thereof, or a salt thereof as an active ingredient. The fusarisetin compound contained in the composition of the present invention shows action effects of suppressing melanin biosynthesis and inhibiting tyrosinase or Trp-1 expression, and as a result, the composition containing a fusarisetin compound can be used for skin whitening or for prevention, alleviation, or treatment of pigmentation.

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18-06-2018 дата публикации

METHOD FOR PREDICTING DEPARTURE TIME AND APPARATUS FOR EXECUTING SAME

Номер: KR1020180065794A
Принадлежит:

Disclosed are a method for predicting a departure time and an apparatus for executing the same. According to an embodiment, provided is an apparatus for predicting departure time which includes: an input unit for receiving arrival input information including a departure point, a destination, and an arrival time from a user; a data extracting unit for extracting past traffic information about the roads from the departure point to the destination based on the arrival input information corresponding to the arrival time; a predicted passing time calculating unit for calculating a predicted passing time for each road section of the roads from the departure point to the destination based on the extracted past traffic information; and a route setting unit for setting, as nodes, bifurcation points of each road section between the destination and the departure point on the basis of the destination, wherein the route setting unit calculates an optimal route from the destination to the departure point ...

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30-06-2016 дата публикации

probes, kits and methods for detecting mutation of filaggrin gene

Номер: KR0101634958B1
Принадлежит: 한국생명공학연구원

... 본 발명은 필라그린(filaggrin) 유전자 돌연변이 핵산 서열에 상보적으로 결합하는 프로브 및 이를 이용한 필라그린 유전자 돌연변이 검출 방법에 관한 것으로, 구체적으로 필라그린 유전자에 상보적으로 결합하는 PNA 프로브를 제조하고 정상형과 돌연변이형의 결합력의 차이를 이용한 FMCA를 사용하여 필라그린 유전자 돌연변이를 간단하고 신속하며 정확하게 판별할 수 있는 편리함을 제공함으로써, 아토피 피부염 환자의 병인학적 요인진단이 가능해지고, 특히 출생 직 후인 영유아 시기에 아토피 피부염 발병 가능성을 신속히 진단하여 발병률을 저하시킬 수 있다 ...

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13-03-2014 дата публикации

ETHYL(2-METHYL-3{(E)-[(NAPHTHA[2,1-B]FURAN-2-YLCARBONYL)HYDRAZONO]METHYL}-1H-INDOLE-1-YL)ACETATE, AND COMPOSITION COMPRISING ANALOGUES THEREOF AS ACTIVE COMPONENT, FOR PREVENTING AND TREATING CANCER

Номер: WO2014038894A1
Принадлежит:

The present invention relates to ethyl(2-methyl-3{(E)-[(naphtha[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, which is a novel inhibitor for cell mitosis. The ethyl(2-methyl-3{(E)-[(naphtha[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate inhibits tubulin polymerization during mitosis to thus induce apoptosis. Furthermore, the acetate has excellent effects in cancer cells having multidrug resistance. Therefore, the acetate can be effectively used to treat cell proliferative disorders including various cancers.

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02-12-2015 дата публикации

COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASES CONTAINING PENICILLINOLIDE A ISOLATED FROM MARINE FUNGI AS ACTIVE INGREDIENT

Номер: KR1020150134491A
Принадлежит:

The present invention relates to a novel penicillinolide A compound having anti-inflammatory activity, isolated from a penicillium sp. SF-5292 strain, and the use thereof. According to the present invention, penicillinolide A isolated from marine fungi: effectively suppresses the generation and activation of IL-1β, TNF-α, IL-6, NO and PGE2, which are cytokines associated with inflammation; effectively inhibits the secretion of NO that can directly induce inflammation; suppresses the movement of inflammation-inducing protein expression inhibitors into nuclei; increases the expression and activation of HO-1 known as an enzyme which exhibits cytoprotective effects from damage caused by oxidative stress; and has low cytotoxicity as a substance derived from natural products and thus is less likely to cause problems related to safety and adverse effects. Therefore, the compound of the present invention can be usefully utilized as a composition for preventing or treating inflammatory diseases.

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09-08-2018 дата публикации

NOVEL MACROLIDE-BASED COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MALARIA AND CONTAINING SAME AS ACTIVE INGREDIENT

Номер: WO2018080072A3
Принадлежит:

The present invention relates to a novel macrolide-based compound, a method for producing the same, and a pharmaceutical composition, which is for preventing or treating malaria and contains the novel macrolide-based compound as an active ingredient. The macrolide-based compound represented by chemical formula 1 according to the present invention effectively exhibits an antiprotozoal activity against Plasmodium sp. protozoan, and thus can be usefully used to prevent or treat malaria.

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25-10-2017 дата публикации

신규한 인돌 유도체 및 이를 포함하는 항암 조성물

Номер: KR0101790193B1
Принадлежит: 한국생명공학연구원

... 본 발명은 신규한 세포 유사분열 저해제인 인돌 유도체, 이의 입체이성질체 또는 이의 약제학적으로 허용가능한 염, 치료용 약제를 위한 이의 용도, 이를 함유하는 조성물과 상기 조성물을 이용한 치료방법 및 이의 제조방법에 관한 것이다. 본 발명에 따른 인돌 유도체, 이의 입체이성질체 또는 이의 약제학적으로 허용가능한 염은 유사분열 과정에서 튜불린의 중합을 저해하여 세포자살을 유도하며, 다제약 내성을 보이는 암세포에도 항암 효과가 우수하다.

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12-10-2017 дата публикации

DIELECTRIC WAVEGUIDE FILTER

Номер: KR1020170112583A
Принадлежит:

The present invention provides a dielectric waveguide filter which decreases a frequency band width, is suitable for miniaturization, minimizes interference between coupling components, and reduces a process difficulty. The dielectric waveguide filter of the present invention comprises: a first block of a dielectric material including at least three resonators applying a conductive material to a surface and slits formed between the resonators; a second block of the dielectric material including resonators applying the conductive material to the surface, wherein the resonators have the same number of the resonators of the first block, and slits formed between the resonators, and disposed in contact with the first block; and a main coupler formed toward the contact surface from the resonator in which the resonator only adjacent to one side exists among the resonators of the first block and the resonator of the second block in contact with the same. The main coupler is formed by being deviated ...

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30-10-2014 дата публикации

NOVEL TUBULIN POLYMERIZATION INHIBITOR AND METHOD FOR SYNTHESIZING SAME

Номер: WO2014175623A1
Принадлежит:

The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.

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23-12-2015 дата публикации

PROVE, KIT, AND METHOD FOR DETECTING MUTATION IN FILAGGRIN GENE

Номер: KR1020150143025A
Принадлежит:

The present invention relates to a probe complementarily binding to mutated nucleic acid sequences in a filaggrin gene, and to a method for detecting mutation in the filaggrin gene using the same. More specifically, the probe of the present invention offers convenience to precisely detect mutation in the filaggrin gene in a rapid and simple way, by synthesizing a peptide nucleic acid (PNA) probe which complementarily binds to the filaggrin gene and also by using a fluorescence melting curve analysis (FMCA) on the difference in binding force between a wild type and a mutant type. Furthermore, the probe ensures diagnosis of etiological factors in a patient with atopic dermatitis. Especially, the probe can be used in a rapid diagnosis on risks of developing atopic dermatitis in infants and toddlers right after birth, thereby decreasing incidence of the disease. COPYRIGHT KIPO 2016 (A1,A2,A3,A4,A5,A6) Temperature, °C ...

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14-03-2018 дата публикации

REINFORCING BAR ATTACHED-WALL SYSTEM CAPABLE OF BEING DETACHED FROM FORM AND FORM CONSTRUCTION METHOD USING SAME

Номер: KR1020180027159A
Принадлежит:

The present invention relates to a wall system used for a form, comprising: a deck member formed by a rectangular plate; a plurality of reinforcing bar members coupled to one surface of the deck member in a truss shape; and reinforcing members installed on both sides of the other surface of the deck member and installed to be spaced apart from the both ends at a predetermined interval. The reinforcing bar member comprises: an upper main-reinforcing bar placed in the height direction of a wall; a pair of lower main-reinforcing bars placed on both sides of a lower part based on the upper main-reinforcing bar; a lattice reinforcing bar connected to the upper main-reinforcing bar and the lower main-reinforcing bars in the diagonal direction; an upper horizontal-reinforcing bar placed on the upper main-reinforcing bar in the perpendicular direction; and a lower horizontal-reinforcing bar placed by being vertically hung on a lower part of the lower main-reinforcing bars. The lower main-reinforcing ...

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26-01-2012 дата публикации

NOVEL FUSARISETIN COMPOUNDS, AND USE THEREOF

Номер: WO2012011741A9
Принадлежит:

The present invention relates to novel fusarisetin compounds separated from Fusarium sp. FN080326 and having an anticancer activity, and to the use thereof. In detail, novel fusarisetin compounds separated and purified from Fusarium sp. FN080326, which is in turn separated from a soil sample, have an inhibitory activity on the proliferation and transfer of cancer cells such as breast-cancer cells, liver-cancer cells or myeloid-leukemic cells. Therefore, the compounds can be effectively used for anticancer compositions containing the compounds as active ingredients.

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12-03-2015 дата публикации

TIME DIFFERENCE-BASED GENERATOR USING BALANCE OF BOTH POLES

Номер: WO2015034255A1
Автор: AN, Jong-Suk
Принадлежит:

The present invention relates to a time difference-based generator using the balance of both poles and specifically comprises: a pair of fixing plates, each having a rotating-shaft through-hole formed in the center thereof and a plurality of ferrite core fixing holes formed along a circle with a predetermined diameter; a plurality of ferrite cores fixedly provided between the pair of fixing plates in such a manner that the ends of the ferrite cores are inserted into the ferrite core fixing holes, the ferrite cores allowing the magnetic field to make a closed circuit; a plurality of winding coils provided in such a manner to be wound around the outer circumference of the ferrite cores by a predetermined number of rotation; a pair of rotating plates for rotors, arranged adjacent to the outer surface of the pair of fixing plates and fixed to the ends of a rotating shaft provided in such a manner to pass through the rotating-shaft through-holes formed in the center of the fixing plates; and ...

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19-05-2017 дата публикации

INDUCIBLE DEFENSE SYSTEM USING SOFTWARE DEFINED NETWORK AND OPERATION METHOD THEREOF

Номер: KR1020170055053A
Принадлежит:

An inducible defense system using a software defined network comprises an external network, an actual server where a provided service application is executed, a disguised server, a network gateway, and a software defined network control unit. The disguised server is physically separated from the actual server, and if a suspicious access attempt from the external network is detected, denies the access to the actual server and induces a bypass access. The network gateway is located between the external network and the actual server and switches an access to the actual server and the disguised server. The software defined network control unit analyzes an access attempt from the external network and controls switching of the network gateway. The disguised server includes a plurality of disguised hosts and at least one virtual host. COPYRIGHT KIPO 2017 (AA) Control signal (BB) Data signal ...

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26-09-2022 дата публикации

페날레논 유도체를 유효성분으로 포함하는 숙취해소용 조성물

Номер: KR102447255B1
Принадлежит: 성균관대학교산학협력단

... 본 발명은 페날레논 유도체를 유효성분으로 포함하는 숙취해소용 조성물 등에 관한 것으로, 본 발명의 페날레논 유도체 화합물들은 활성 산소 소거능과 아세트 알데하이드 독성 억제 효과가 우수할 뿐만 아니라, 합성물질이 아닌 천연물로써 부작용을 최소화할 수 있다. 또한, 배양이 가능한 곰팡이 (페니실리움 헤르퀘이(P. herquei))를 이용하기 때문에 추출 및 정제에 경제적이다.

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02-11-2016 дата публикации

신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물

Номер: KR0101671325B1
Принадлежит: 한국생명공학연구원

... 본 발명은 신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 포함하는 항균용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 고리형 뎁시펩타이드계 화합물, 이의 광학 이성질체, 또는 이의 약학적으로 허용 가능한 염은 황색포도상구균(Staphylococcus aureus) 및 살모넬라균(Salmonella typhimurium)에 대한 저해활성을 나타내므로, 항균용 조성물, 항균용 약학적 조성물, 항균용 사료 조성물 또는 항균용 화장료 조성물로 유용하게 사용할 수 있다.

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12-02-2016 дата публикации

PHENYL DERIVATIVE, MANUFACTURING METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CELL PROLIFERATIVE DISEASES

Номер: KR1020160014975A
Принадлежит:

The present invention relates to: a phenyl derivative, an optical isomer thereof, or a pharmaceutically acceptable salt thereof; a manufacturing method thereof; and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cell proliferative diseases. A compound of the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof can be usefully used for treating cell proliferative diseases such as various cancers, by depolymerizing a microtubule and generating apoptosis, and being effectively applied to cancer cells which exhibit multiple drug resistance. COPYRIGHT KIPO 2016 (AA,CC) Relative cell growth (BB,DD) Inhibition (%) ...

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05-04-2016 дата публикации

CULTIVATOR HAVING FUNCTION OF FORMING SEEDLING TRANSPLANTATION HOLES AND ROTARY DRUM FOR FORMING TRANSPLANTATION HOLES

Номер: KR101609238B1
Принадлежит: SONG JU-KUN

The present invention relates to a cultivator having a function of forming seedling transplantation holes and a rotary drum for forming the transplantation holes. Particularly, a cultivator having a function of forming seedling transplantation holes according to the present invention includes a pair of weight rollers (2, 2′) mounted instead of wheels on both sides of an agricultural cultivator (1), an installation frame (3) installed on the rear of the agricultural cultivator (1), a rotary drum (4) as a rotary shaft (41) mounted on a central part of the installation frame (3), and several transplantation hole forming elements (5) which are installed on the outer circumference of the rotary drum (4) with being spaced apart from each other in an equal distance, and each of which is rotated to a predetermined angle. Further, the present invention is characterized in that it provides a merit that is capable of performing multiple continuous processes of forming transplantation holes in the ...

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04-07-2017 дата публикации

소프트웨어 정의 네트워크를 이용한 유도 방어 시스템 및 그 구동 방법

Номер: KR0101750372B1
Принадлежит: 주식회사 나임네트웍스

... 소프트웨어 정의 네트워크를 이용한 유도 방어 시스템은 외부 네트워크, 제공되는 서비스 어플리케이션이 구동되는 실제 서버, 위장 서버, 네트워크 게이트웨이, 소프트웨어 정의 네트워크 제어부를 포함한다. 이러한 위장 서버는 상기 실제 서버와 물리적으로 독립되고, 상기 외부 네트워크로부터의 접속 시도가 의심스러운 경우, 상기 실제 서버에 접속을 허용하지 않고, 우회하여 외부와 접속하도록 한다. 이러한 네트워크 게이트웨이는 상기 외부 네트워크와 상기 실제 서버에 사이에 위치하며, 상기 실제 서버와 상기 위장 서버로의 접속을 스위칭 한다. 소프트웨어 정의 네트워크 제어부는 상기 외부 네트워크로부터의 접속 시도를 분석하고, 상기 네트워크 게이트웨이의 스위칭을 제어한다. 상기 위장 서버는 복수개의 위장 호스트 및 적어도 하나 이상의 가상 호스트를 포함한다.

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13-05-2016 дата публикации

Composition for the prevention and treatment of inflammatory diseases comprising the penicillinolide A isolated from marine fungi

Номер: KR0101620815B1
Принадлежит: 한국생명공학연구원

... 본 발명은 페니실리움 속(Penicillium sp.) SF-5292 균주로부터 분리한 항염활성을 갖는 신규한 페니실리놀라이드(Penicillinolide) A 화합물 및 이의 용도에 관한 것으로서, 본 발명의 해양 진균에서 분리한 페니실리놀라이드 A는 염증과 관련된 사이토카인인 IL-1β, TNF-α, IL-6, NO 및 PGE2의 생성 및 활성화를 효과적으로 억제하고, 염증을 직접적으로 유도할 수 있는 NO의 분비를 효과적으로 억제하며, 염증 유도 단백질 발현 억제 물질의 핵 내로의 이동을 억제하고, 산화적 스트레스로 인한 손상으로부터의 세포보호효과를 나타내는 효소로 알려진 HO-1의 발현 및 활성을 증가시키며, 천연물 유래 물질로 세포 독성도 낮아 안전성 및 부작용 관련 문제가 발생될 가능성도 낮으므로, 본 발명의 화합물은 염증성 질환 예방 또는 치료를 위한 조성물로 유용하게 사용될 수 있다.

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20-07-2016 дата публикации

NOVEL CYCLIC DEPSIPEPTIDE-BASED COMPOUND, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL ANTIBACTERIAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

Номер: KR1020160086479A
Принадлежит:

The present invention relates to a novel cyclic depsipeptide-based compound, a production method thereof, and a pharmaceutical antibacterial composition containing the same as an active ingredient. According to the present invention, the novel cyclic depsipeptide-based compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof exhibits inhibitory activity against Staphylococcus aureus and Salmonella typhimurium, thereby being useful for antibacterial compositions, pharmaceutical antibacterial compositions, antibacterial feed compositions, or antibacterial cosmetic compositions. COPYRIGHT KIPO 2016 ...

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02-03-2016 дата публикации

VACUUM MOTOR HAVING TIME DIFFERENCE GENERATOR USING BALANCE MOTION OF BOTH POLES

Номер: KR1020160022740A
Автор: AN, JONG SUK
Принадлежит:

The present invention relates to a vacuum motor having a time difference generator using balance motion of both poles. In particular, the vacuum motor having a time difference generator using balance motion of both poles comprises: a case which includes a lower cap having a pot shape and an upper cap having a lid shape and is in a vacuum; the time difference generator vertically fixed in a mounting groove formed in the center of the lower cap of the case, and generating a voltage independently with different time differences by a winding coil wound around each of a plurality of ferrite cores when a power supply voltage is supplied to a driving motor; and a motor having a plurality of wheel driving cores, a fly wheel, and a plurality of permanent magnets for wheel driving fixed and rotated in the case, having a cap for combining an external rotary shaft and the external rotary shaft rotatably provided outside a shaft guider protruding upwardly from the center point of the upper cap of the ...

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30-03-2017 дата публикации

페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물

Номер: KR0101721490B1
Принадлежит: 한국생명공학연구원

... 본 발명은 페닐 유도체, 이의 광학 이성질체, 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명의 화합물, 이의 광학 이성질체, 또는 이의 약학적으로 허용 가능한 염은 미세소관을 탈중합시켜 세포자살(apoptosis)을 유발하고, 다제약내성을 보이는 암세포에도 효과적으로 작용하므로, 다양한 암을 비롯한 세포증식성 질병의 치료에 유용하게 사용될 수 있다.

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28-12-2017 дата публикации

NOVEL SESQUITERPENIC DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BONE DISEASE WHILE INCLUDING SAME AS ACTIVE INGREDIENT

Номер: KR101813112B1

The present invention relates to a novel sesquiterpene derivative, a preparing method for the same, and a pharmaceutical composition including the same as an active ingredient for preventing or treating bone diseases. According to the present invention, the compound being the novel sesquiterpene derivative represented by the chemical formula 1 and stereoisomers of the same or pharmaceutically acceptable salt of the same have excellent osteoclast formation inhibiting capabilities and suppress the destruction or absorption of bone tissues accordingly, thereby making the pharmaceutical composition including the same as an active ingredient for preventing or treating bone diseases useful. COPYRIGHT KIPO 2018 ...

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11-10-2022 дата публикации

콜히친을 포함하는 알레르기성 피부 질환 또는 피부 소양증 치료용 조성물

Номер: KR20220136979A
Принадлежит:

... 본 발명은 콜히친(colchicine)을 포함하는 조성물에 관한 것이다. 본 발명에 따른 조성물은 알레르기성 피부 질환의 발병과 관련이 높은 필라그린의 발현량을 증진시키고, 피부 보습 효과를 증진시켜 피부 장벽 기능을 개선시킬 뿐만 아니라, 알레르기성 피부 질환의 염증 반응 등을 조절하여 알레르기성 피부 질환 및/또는 피부 소양증의 예방 및 치료와 피부 보습 및 피부 상태 개선에 우수한 효과를 나타낸다.

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24-08-2017 дата публикации

NOVEL INDOLE DERIVATIVE AND ANTI-CANCER COMPOSITION CONTAINING SAME

Номер: WO2017142269A1
Принадлежит:

The present invention relates to: an indole derivative, which is a novel cell mitosis inhibitor; a stereoisomer thereof or a pharmaceutically acceptable salt thereof; a use thereof as a therapeutic agent; a composition containing the same and a treatment method using the composition; and a preparation method therefor. According to the present invention, the indole derivative, the stereoisomer thereof or the pharmaceutically acceptable salt thereof, inhibits the tubulin polymerization during mitosis so as to induce apoptosis, and has an excellent anti-cancer effect also in cancer cells having multiple drug resistance.

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08-07-2010 дата публикации

TRANSFORMER USING COUPLED-CORE STRUCTURE

Номер: KR2010076934A1
Автор: AN, Jong Suk
Принадлежит:

The present invention relates to a transformer using a coupled-core structure. More specifically, the invention concerns the transformer using the coupled-core structure that is able to minimize heat generation and other phenomena in a coil resulting from the counter electromotive force which is inevitably generated by a core structure or wire-winding method of a conventional transformer. The invention provides the coupled-core structure to minimize the heat generation of a coil caused by the counter electromotive force.

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16-03-2018 дата публикации

ANTI-INFLAMMATORY COMPOSITION COMPRISING ACYLHYDRAZONE DERIVATIVES

Номер: KR101839391B1

The present invention relates to a pharmaceutical composition for preventing or treating an inflammatory disease comprising an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof as an active ingredient. The present invention also relates to a food composition for preventing or ameliorating an inflammatory disease comprising the compound or a stereoisomer thereof as an active ingredient. The present invention also relates to a cosmetic composition for preventing or improving dermatitis comprising the compound or a stereoisomer thereof as an active ingredient. COPYRIGHT KIPO 2018 ...

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18-06-2018 дата публикации

METHOD AND APPARATUS FOR ANALYZING CAR COMMUNICATION NETWORK

Номер: KR1020180065083A
Автор: AHN, JONG SUK
Принадлежит:

An embodiment of the present invention relates to a method and an apparatus for analyzing a car communication network. The method for analyzing a car communication network according to one embodiment of the present invention comprises the steps of: extracting at least one device identifier respectively from a first log file generated before an event occurs due to a device to be identified and a second log file generated after an event occurs due to a device to be identified; and comparing the device identifier extracted from the first log file to the device identifier extracted from the second log file to determine the device identifier extracted only from the second log file as an identifier of the device to be identified. According to embodiments of the present invention, a simple comparison and analysis method is used to identify a device identifier of devices in a car. COPYRIGHT KIPO 2018 (401) Generate a first log file based on data frames obtained within a first time section (403) ...

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