Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 20. Отображено 20.
22-09-2011 дата публикации

TNF-Α AND TWEAK DUAL ANTAGONIST FOR THE PROPHYLAXIS AND TREATMENT OF AUTOIMMUNE DISEASES

Номер: WO2011115456A2
Автор: PARK, Young Woo, JO, Ki Won, YOO, Srok Ho, YU, Jung, KIM, Dong Jin, YOON, Sun-Ha, SONG, Eun Jung, LEE, Eun Kyung, OH, Jin Mi, CHO, Kyu Won, CHO, Mi La, KIM, Ho Youn, PARK, Mi Kyung, OH, Hye Jwa, PARK, Jin Sil, WOO, Yun Ju, BYUN, Jae Kyeong, RYU, Jun Geol
Принадлежит:

The present invention relates to a TNFR2-TWEAKR fusion protein, and more specifically the TNFR2-TWEAKR fusion protein of the present invention can be used advantageously as an active ingredient in compositions that are efficacious in the prophylaxis and treatment of autoimmune diseases since TNFR2-TWEAKR fusion protein plays the role of a dual antagonist with respect to TNF-α and TWEAK which are known to be major causes of one type of autoimmune disease namely autoimmune arthritis, and, when Th17 cells are treated with a composition comprising TNFR2-TWEAKR fusion protein as an active ingredient, secretion of inflammatory cytokine IL-17 is reduced while secretion of anti-inflammatory cytokine IL-10 produced from Treg cells is increased, and this effect means that not only is the effect of TNFR2-TWEAKR fusion protein far better than TNFR2-Fc and TWEAK-Fc single proteins, but also not only is a therapeutic effect exhibited against arthritis in CIA arthritic mice but also a therapeutic effect ...

Подробнее
Номер записи: 1
24-04-2017 дата публикации

메트포민을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물

Номер: KR0101729348B1
Автор: 조미라, 박민정, 이성희, 이선영, 손혜진, 유준걸, 양은지
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역반응의 이상으로 유발되는 면역질환을 예방 또는 치료하는데 사용되는 메트포민(metformin) 화합물의 약학적 용도에 관한 것으로서, 보다 구체적으로는 메트포민(metformin) 화합물을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 메트포민(metformin) 화합물은 염증성 사이토카인을 생성 및 분비하는 세포 독성 Th17 세포로의 분화를 억제하는 효과가 우수하고, 비정상적으로 활성화된 면역세포의 기능을 억제하고 염증 반응을 제어하는 특성을 갖는 면역조절 T 세포(Treg)의 활성을 증진시키는 효과가 우수하며, 조절 T 세포(Treg)의 Th17 세포로의 분화가변성(plasticity)을 억제하는 활성을 통하여 조절 T 세포(Treg)로서의 기능을 효과적으로 유지 및 강화시키는 효과가 우수하여, 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 약학적 조성물 또는 면역 억제제로 유용하게 사용할 수 있다.

Подробнее
Номер записи: 2
27-03-2014 дата публикации

COMPOSITION COMPRISING METFORMIN AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASE

Номер: WO2014046474A2
Автор: CHO, Mi-La, LEE, Seon-Yeong, YANG, Eun-Ji, SON, Hye-Jin, KIM, Eun-Kyung, RYU, Jun-Geol
Принадлежит:

The present invention relates to a composition comprising metformin as an active ingredient for preventing or treating inflammatory bowel disease. The metformin compound or the metformin-etanercept (product name: Enbrel) composite according to the present invention may have excellent effects of maintaining the thickness of the small intestine and length of the large intestine normal, inhibiting or decreasing the activity of IL-17 and TNF-a, and promoting or increasing the activity of IFNr, and therefore can be effectively used as a pharmaceutical composition for preventing or treating autoimmune diseases including inflammatory bowel disease.

Подробнее
Номер записи: 3
22-09-2011 дата публикации

DUAL ANTAGONIST FOR TNF-Α AND IL-21 FOR PREVENTING AND TREATING AUTOIMMUNE DISEASES

Номер: WO2011115458A3
Автор: PARK, Young Woo, JO, Ki Won, YOO, Srok Ho, YU, Jung, YOON, Sun-Ha, PARK, Ji Hyun, SONG, Eun Jung, LEE, Jong-Ho, SEO, Min Ji, CHO, Sun Jung, CHO, Mi La, KIM, Ho Youn, PARK, Mi Kyung, OH, Hye Jwa, PARK, Jin Sil, WOO, Yun Ju, BYUN, Jae Kyeong, RYU, Jun Geol
Принадлежит:

The present invention relates to a TNFR2-IL21R fusion protein acting as a dual antagonist for TNF-α and IL-21. More specifically, a composition containing the dual antagonist (TNFR2-IL21R fusion protein) for TNF-α and IL-21 which are known as the main cause of autoimmune arthritis, one of autoimmune diseases, more remarkably reduces the secretion of inflammatory cytokine, increases the secretion of anti-inflammatory cytokine, and suppresses the differentiation of osteoclast compared with the case using TNFR2-Fc and IL21R-Fc single proteins. In addition, the composition treats arthritis of collagen-induced arthritis (CIA) mice and increases the expression of Treg cells, an immunosuppressive cell, thereby treating autoimmune arthritis. Therefore, the TNFR2-IL21R fusion protein according to the present invention can be used as an active ingredient of a composition for preventing and treating autoimmune diseases.

Подробнее
Номер записи: 4
13-03-2014 дата публикации

COMPOSITION COMPRISING GRIM-19 AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING OBESITY OR LIPID-RELATED METABOLIC DISEASES

Номер: WO2014038823A1
Автор: CHO, Mi-La, JHUN, Joo-Yeon, LEE, Seon-Yeong, MUN, Yeong-Mi, RYU, Jun-Geol, BYUN, Jae-Kyeong, SON, Hye-Jin, KIM, Eun-Kyung, YANG, Eun-Ji, JEONG, Jeong-Hee
Принадлежит:

The present invention relates to a composition comprising GRIM-19 protein as an active ingredient for preventing or treating obesity or lipid-related metabolic diseases. More particularly, the present invention relates to a composition for preventing or treating obesity or lipid-related metabolic diseases wherein the composition comprises GRIM-19 protein as an active ingredient for preventing or treating metabolic diseases caused by immune response disorders or interactions between genetic, metabolic, or environmental complex factors. The GRIM-19 protein according to the present invention exhibits excellent effectiveness not only in reducing lipocytes and total cholesterol content in the body, but also in suppressing the differentiation of cytotoxic Th17 cells that produce and secrete an inflammatory cytokine. Also, GRIM-19 has been found to have excellent effectiveness in regulating a STAT3 mediated inflammatory response in an inflammatory environment related to obesity. Thus, the present ...

Подробнее
Номер записи: 5
24-01-2017 дата публикации

ＪｕｎＢ의 발현 또는 활성 억제제를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물

Номер: KR0101699567B1
Автор: 조미라, 문영미, 이선영, 허양미, 유준걸, 손혜진
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 JunB의 발현 또는 활성 억제제를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물에 관한 것으로서 보다 구체적으로 본 발명은 JunB 유전자의 mRNA에 상보적으로 결합하는 안티센스 뉴클레오티드, 작은 간섭 RNA(short interfering RNA), 짧은 헤어핀 RNA(short hairpin RNA) 및 JunB 단백질에 대한 항체로 이루어진 군 중에서 선택되는 어느 하나를 포함하는 면역질환의 예방 또는 치료용 약학적 조성물 및 이를 이용한 면역질환의 예방 또는 치료방법에 관한 것이다. 본 발명에 따르면, JunB의 발현 또는 활성을 억제하는 경우 면역질환을 유발하는 Th17 세포의 분화를 억제하고, 염증성 사이토카인인 IL-17의 생성을 억제하며, 염증성 자가 항체를 억제하고, 항원에 의한 면역세포의 증식을 억제하는 활성이 우수하여, 면역조절 이상으로 유발되는 각종 면역질환을 치료하기 위한 치료제의 제조에 널리 활용할 수 있다.

Подробнее
Номер записи: 6
22-09-2011 дата публикации

DUAL ANTAGONIST FOR TNF-Α AND IL-21 FOR PREVENTING AND TREATING AUTOIMMUNE DISEASES

Номер: WO2011115458A2
Автор: PARK, Young Woo, JO, Ki Won, YOO, Srok Ho, YU, Jung, YOON, Sun-Ha, PARK, Ji Hyun, SONG, Eun Jung, LEE, Jong-Ho, SEO, Min Ji, CHO, Sun Jung, CHO, Mi La, KIM, Ho Youn, PARK, Mi Kyung, OH, Hye Jwa, PARK, Jin Sil, WOO, Yun Ju, BYUN, Jae Kyeong, RYU, Jun Geol
Принадлежит:

The present invention relates to a TNFR2-IL21R fusion protein acting as a dual antagonist for TNF-α and IL-21. More specifically, a composition containing the dual antagonist (TNFR2-IL21R fusion protein) for TNF-α and IL-21 which are known as the main cause of autoimmune arthritis, one of autoimmune diseases, more remarkably reduces the secretion of inflammatory cytokine, increases the secretion of anti-inflammatory cytokine, and suppresses the differentiation of osteoclast compared with the case using TNFR2-Fc and IL21R-Fc single proteins. In addition, the composition treats arthritis of collagen-induced arthritis (CIA) mice and increases the expression of Treg cells, an immunosuppressive cell, thereby treating autoimmune arthritis. Therefore, the TNFR2-IL21R fusion protein according to the present invention can be used as an active ingredient of a composition for preventing and treating autoimmune diseases.

Подробнее
Номер записи: 7
17-07-2014 дата публикации

COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES, CONTAINING HTRA2 AS ACTIVE INGREDIENT

Номер: WO2014109617A1
Автор: RHIM, Hyang-Shuk, CHO, Mi-La, MUN, Yeong-Mi, LEE, Seon-Yeong, LEE, Jae-Seon, RYU, Jun-Geol, SON, Hye-Jin, HER, Yang-Mi, NAM, Min-Kyung, SHIN, Hyun-Ah, KIM, Jae-Kyung, SEO, Hyeon-Beom
Принадлежит:

The present invention relates to a composition for preventing or treating autoimmune diseases, containing high temperature requirement protein A2 (HtrA2) as an active ingredient. The HtrA2 according to the present invention reduces the expression of STAT3, which is a Th17 cell transcription factor, inhibits the expression of inflammatory cytokines, and promotes the activity of a regulatory T cell (Treg), thereby regulating an excessive immune response through a mechanism, and thus it is possible to effectively treat autoimmune diseases caused by the abnormal regulation of an inflammatory response and various immune responses.

Подробнее
Номер записи: 8
06-08-2020 дата публикации

COMPOSITION COMPRISING MLS-STAT3 FOR PREVENTION OR TREATMENT OF IMMUNE DISEASE

Номер: WO2020159191A1
Автор: CHO, Mi-La, PARK, Sung-Hwan, LEE, Seon-Yeong, MOON, Su-Jin, KIM, Eun-Kyung, RYU, Jun-Geol, CHOI, Si-Yeong, CHOI, Jeong-Won, JUNG, Kyung-Ah, LEE, A-Ram, YANG, Chul-Woo, MOON, Jeong-Hyeon
Принадлежит:

The present invention relates to: a recombinant peptide in which a Mitochondria Localization Sequence (MLS) peptide and the Signal Transducer and Activator of Transcription 3 (STAT3) are fused to each other; a recombinant vector carrying a polynucleotide coding for the recombinant peptide; and a composition comprising the recombinant peptide or the recombinant vector as an active ingredient for prevention or treatment of autoimmune disease or inflammatory disease, wherein the recombinant peptide or the recombinant vector allows STAT3 to be overexpressed in the mitochondria to enhance the mitochondrial function, resulting in inhibiting the expression of inflammatory cytokines including IL-17, whereby the composition can be advantageously used for preventing or treating autoimmune disease or inflammatory diseases.

Подробнее
Номер записи: 9
27-03-2014 дата публикации

COMPOSITION COMPRISING METFORMIN AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASE

Номер: WO2014046474A3
Автор: CHO, Mi-La, LEE, Seon-Yeong, YANG, Eun-Ji, SON, Hye-Jin, KIM, Eun-Kyung, RYU, Jun-Geol
Принадлежит:

The present invention relates to a composition comprising metformin as an active ingredient for preventing or treating inflammatory bowel disease. The metformin compound or the metformin-etanercept (product name: Enbrel) composite according to the present invention may have excellent effects of maintaining the thickness of the small intestine and length of the large intestine normal, inhibiting or decreasing the activity of IL-17 and TNF-a, and promoting or increasing the activity of IFNr, and therefore can be effectively used as a pharmaceutical composition for preventing or treating autoimmune diseases including inflammatory bowel disease.

Подробнее
Номер записи: 10
25-06-2020 дата публикации

NOVEL CYTOKINES AND USE THEREOF

Номер: WO2020130711A1
Автор: CHO, Mi-La, YANG, Chul-Woo, PARK, Sung-Hwan, LEE, Seon-Yeong, MOON, Young-Mee, KWOK, Seung-Ki, SEO, Hyeon-Beom, RYU, Jun-Geol, KIM, Eun-Kyung
Принадлежит:

The present invention relates to a novel composite that is formed by linking subunit p40 and subunit EBI3 via a linker and has excellent anti-inflammatory effects and immunomodulatory effects.

Подробнее
Номер записи: 11
24-05-2017 дата публикации

조절 Ｔ 세포의 분화 가변성을 억제하는 탄시논 ⅡＡ의 신규 용도

Номер: KR0101739601B1
Автор: 양철우, 조미라, 이선영, 문영미, 허양미, 손혜진, 유준걸
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 조절 T 세포(Treg)의 분화 가변성을 억제하는 탄시논(Tanshinone) IIA 화합물의 신규 용도에 관한 것으로, 자세하게는 탄시논 IIA 화합물을 유효성분으로 함유하는 조절 T 세포(Treg)의 Th17 세포로의 분화 억제용 조성물; 탄시논 IIA 화합물 및 조절 T 세포(Treg)를 유효성분으로 함유하는 면역질환의 예방 또는 치료용 조성물 및 탄시논 IIA 화합물을 이용한 면역억제 기능이 유지되는 조절 T 세포(Treg) 제조방법에 관한 것이다. 본 발명에 따른 탄시논 IIA 화합물은 조절 T 세포(Treg)의 Th17 세포로의 분화가변성(plasticity)을 억제하는 활성을 통하여 조절 T 세포(Treg)로서의 기능을 효과적으로 유지 및 강화시키는 신규 용도를 가지므로, 이를 조절 T 세포(Treg)와 함께 병행하여 사용하는 경우, 병적 환경 하에서도 조절 T 세포(Treg)의 Th17 세포로의 분화를 차단할 수 있어 보다 효과적인 면역질환 치료를 위한 치료제를 제공할 수 있는 효과가 있다.

Подробнее
Номер записи: 12
22-09-2011 дата публикации

TNF-Α AND TWEAK DUAL ANTAGONIST FOR THE PROPHYLAXIS AND TREATMENT OF AUTOIMMUNE DISEASES

Номер: WO2011115456A3
Автор: PARK, Young Woo, JO, Ki Won, YOO, Srok Ho, YU, Jung, KIM, Dong Jin, YOON, Sun-Ha, SONG, Eun Jung, LEE, Eun Kyung, OH, Jin Mi, CHO, Kyu Won, CHO, Mi La, KIM, Ho Youn, PARK, Mi Kyung, OH, Hye Jwa, PARK, Jin Sil, WOO, Yun Ju, BYUN, Jae Kyeong, RYU, Jun Geol
Принадлежит:

The present invention relates to a TNFR2-TWEAKR fusion protein, and more specifically the TNFR2-TWEAKR fusion protein of the present invention can be used advantageously as an active ingredient in compositions that are efficacious in the prophylaxis and treatment of autoimmune diseases since TNFR2-TWEAKR fusion protein plays the role of a dual antagonist with respect to TNF-α and TWEAK which are known to be major causes of one type of autoimmune disease namely autoimmune arthritis, and, when Th17 cells are treated with a composition comprising TNFR2-TWEAKR fusion protein as an active ingredient, secretion of inflammatory cytokine IL-17 is reduced while secretion of anti-inflammatory cytokine IL-10 produced from Treg cells is increased, and this effect means that not only is the effect of TNFR2-TWEAKR fusion protein far better than TNFR2-Fc and TWEAK-Fc single proteins, but also not only is a therapeutic effect exhibited against arthritis in CIA arthritic mice but also a therapeutic effect ...

Подробнее
Номер записи: 13
21-01-2016 дата публикации

Composition for preventing or treating immune disease comprising SR11302

Номер: KR0101587687B1
Автор: 양철우, 조미라, 이선영, 문영미, 허양미, 손혜진, 유준걸, 이성희, 박민정
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 SR11302 화합물을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물에 관한 것으로서, 보다 구체적으로 본 발명은 SR11302 화합물 또는 그의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 화합물은 염증성 사이토카인을 생성 및 분비하는 세포 독성 Th17 세포의 분화를 억제하는 효과가 우수하고, 비정상적으로 활성화된 면역세포의 기능을 억제하고 염증 반응을 제어하는 특성을 갖는 면역조절 T 세포(Treg)의 활성을 증진시키는 효과가 우수하므로 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 약학적 조성물 또는 면역 억제제로 유용하게 사용할 수 있다.

Подробнее
Номер записи: 14
06-04-2017 дата публикации

Ｇｒｉｍ19를 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 예방 또는 치료용 조성물

Номер: KR0101724169B1
Автор: 조미라, 전주연, 이선영, 문영미, 유준걸, 변재경, 손혜진, 김은경, 양은지
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 Grim19 단백질을 유효성분으로 포함하는 비만 또는 지질 관련 대사성 질환의 예방 또는 치료용 조성물에 관한 것으로, 특히 면역반응의 이상 또는 유전적, 대사적, 환경적 복잡한 요인의 상호작용에 의해 유발되는 대사성 질환을 예방 또는 치료할 수 있는 Grim19 단백질을 유효성분으로 포함하는 비만 또는 지질 관련 대사성 질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 상기 Grim19 단백질의 경우, 지방세포 감소효과 및 체내 총 콜레스테롤 함량 감소 효과가 우수한 것으로 나타났으며 뿐만 아니라 염증성 사이토카인을 생성 및 분비하는 세포 독성 Th17 세포의 분화를 억제하는 효과가 우수하고, 비만과 관련된 염증 환경을 Grim19가 STAT3를 매개하여 염증반응을 조절하는 효과가 우수하다는 사실을 확인함으로써, 비만 또는 지질 관련 대사성 질환을 효과적으로 치료할 수 있는 치료제 및 기능성 식품의 제조에 사용될 수 있는 효과가 있다.

Подробнее
Номер записи: 15
28-05-2015 дата публикации

COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES, CONTAINING METFORMIN AS ACTIVE INGREDIENT

Номер: WO2015076430A1
Автор: CHO, Mi-La, PARK, Min-Jung, LEE, Sung-Hee, LEE, Seon-Yeong, SON, Hye-Jin, RYU, Jun-Geol, YANG, Eun-Ji
Принадлежит:

The present invention relates to a pharmaceutical use of a metformin compound used to prevent or treat immune diseases caused by abnormal immune responses and, more specifically, to a composition for preventing or treating immune diseases, containing a metformin compound as an active gradient. The metformin compound, according to the present invention, has excellent effects of: inhibiting differentiation into cytotoxic Th17 cell, which generate and secrete inflammatory cytokine; enhancing the activity of immunoregulatory T cells (Treg), which inhibit the functions of abnormally activated immune cells and regulate inflammatory responses; and effectively maintaining and enhancing the functions of the regulatory T cells (Treg) through the activity inhibiting the plasticity of the differentiation of the regulatory T cells (Treg) into Th17 cells. Therefore, the metformin compound is useful as a pharmaceutical composition or an immune inhibitor capable of preventing or treating immune diseases ...

Подробнее
Номер записи: 16
19-09-2018 дата публикации

COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES COMPRISING MIXTURE OF LACTIC ACID BACTERIA

Номер: KR1020180103772A
Автор: CHO MI LA, PARK SUNG HWAN, YANG CHUL WOO, SEON YEONG LEE, JHUN JOO YEON, SEO HYEON BEOM, KWUAN JI YE, RYU JUN GEOL, CHO KEUN HYUNG, CHOI JEONG WON, RYU JAE YOON, KIM EUN KYUNG, JUNG KYUNG AH, LEE SEUNG HOON, LEE AH LUM, NA HYUN SIK
Принадлежит:

The present invention relates to a composition for preventing and treating immune diseases comprising a mixture of lactic acid bacteria and various applications thereof. The composition of the present invention is a mixture of probiotics or prebiotics in the most effective ratio, thereby having an effect of inhibiting an expression of inflammatory cytokines and an expression of cartilage destruction factors when compared with conventional anti-inflammatory drugs in vitro or in vivo. In addition, the cartilage protective factor and anti-inflammatory cytokine expression are enhanced, and cartilage protective effect is confirmed to be excellent in an animal model for immunological diseases, so the composition can be usefully used in related pharmaceutical and health functional food industries. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 17
20-03-2014 дата публикации

COMPOSITION USING METFORMIN FOR PREVENTING OR TREATING IMMUNE DISEASES INCLUDING LUPUS

Номер: WO2014042392A1
Автор: CHO, Mi-La, LEE, Seon-Yeong, PARK, Min-Jung, LEE, Jae-Seon, YANG, Eun-Ji, KIM, Eun-Kyung, RYU, Jun-Geol, SON, Hye-Jjn
Принадлежит:

The present invention relates to a composition for preventing or treating immune diseases through the suppression of B cell activity induced by metformin. More particularly, the present invention relates to a composition comprising a metformin compound or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating immune diseases, wherein the composition is characterized by the suppression or reduction of B cell activity which is a cause of disease. The present invention can be valuable in the use thereof for various autoimmune diseases as an immunosuppressant which can prevent or treat immune diseases by suppressing or reducing B cell activity and Th17 cell activity, which are causes of disease, or by promoting or increasing regulatory T cell activity.

Подробнее
Номер записи: 18
17-11-2011 дата публикации

COMPOSITION CONTAINING PIAS3 AS AN ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER OR IMMUNE DISEASE

Номер: WO2011142514A1
Автор: CHO, Mi-La, LEE, Seon-Yeong, MOON, Young-Mee, RYU, Jun-Geol, HER, Yang-Mi, OH, Hye-Jwa
Принадлежит:

The present invention relates to a composition containing PIAS3 as an active ingredient for the prevention or treatment of cancer or immune disease. More specifically, the present invention relates to a composition containing the PIAS3 gene or an expression protein thereof as an active ingredient for the prevention or treatment of cancer or immune disease, to an immunosuppressant composition, to a method for reducing or inhibiting undifferentiated T cells into Th17 cells using the PIAS3 gene or an expression protein thereof, and to a method for activating regulatory T cells. The PIAS3 according to the present invention is excellent in inhibiting the differentiation of cytotoxic Th17 cells which produce and secrete inflammatory cytokines and in activating regulatory T cells (Tregs) having characteristics that inhibit the function of abnormally activated immune cells and control inflammatory responses. Thus, the PIAS3 may be useful as a pharmaceutical composition or immunosuppressant which ...

Подробнее
Номер записи: 19
18-06-2020 дата публикации

BIFIDOBACTERIUM LUNGUM RAPO STRAIN FOR ALLEVIATION, PREVENTION, OR TREATMENT OF RHEUMATOID ARTHRITIS AND COMPOSITION COMPRISING SAME

Номер: WO2020122396A1
Автор: JI, Geun Eog, JEONG, Yun Ju, PARK, Sang Jun, YOUNG, Su Young, LEE, Hyon Ha, PARK, Sung Hwan, CHO, Mi La, JU, Ji Hyeon, KWOK, Seung Ki, LEE, Joo Ha, KIM, Ji Won, LEE, Seon Yeong, RYU, Jun Geol, JHUN, Joo Yeon, RYU, Jae Yoon
Принадлежит:

The present invention relates to novel Bifidobacterium longum RAPO (accession number: KCTC13773BP) and can provide a composition for alleviation, prevention, or treatment of rheumatoid arthritis, the composition comprising Bifidobacterium longum RAPO (accession number: KCTC13773BP) selected in the present invention.

Подробнее
Номер записи: 20