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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 64. Отображено 64.
02-06-2016 дата публикации

Complex composition comprising metformin, coenzyme Q10 and statin and use for preventing or treating immune disease

Номер: KR0101627046B1
Автор: 조미라, 박성환, 양철우, 이선영, 박민정, 양은지, 손혜진, 이성희, 이정아, 전주연, 정정희, 이은정, 나현식
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역반응의 이상으로 유발되는 면역질환을 예방 또는 치료하는데 사용되는 메트포민, 코엔자임 Q10 및 스타틴의 약학적 용도에 관한 것으로서, 보다 구체적으로는 메트포민, 코엔자임 Q10 및 스타틴을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에 따른 메트포민, 코엔자임 Q10 및 스타틴 병용투여에 의한 면역질환의 치료는 메트포민, 코엔자임 Q10 및 스타틴을 각각 단독으로 처리한 군에 비해 염증성 사이토카인인 TNF-a, IL-17, Th1 및/또는 Th17의 발현을 월등히 억제시키고, 관절염 유도 동물 모델 및 염증성 장질환 유도 동물모델에서 이들 면역질환을 효과적으로 치료할 수 있는 효과가 있다.

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Номер записи: 1
05-11-2015 дата публикации

NOVEL COMPOUND HAVING IMMUNE DISEASE TREATMENT EFFECT AND USE THEREOF

Номер: WO2015167243A1
Автор: CHO, Mi-La, SHIN, Dong-Yun, PARK, Sung-Hwan, YANG, Chul- Woo, CHOI, Jong-Young, PARK, Min-Jung, SON, Hye-Jin, LEE, Sung-Hee, LEE, Seon-Yeong, KIM, Eun-Kyung, KIM, Jae-kyung, LEE, Seung-Hun, PARK, Seong-Hyeok
Принадлежит:

The present invention relates to a novel compound capable of effectively preventing and treating immune diseases and a use thereof. The novel compound of the present invention has effects of inhibiting the production of inflammatory cytokines, increasing the activity of regulatory T cells having immune regulatory functions, inhibiting the production of auto-antibodies to regulate excessive immune responses, and inhibiting the differentiation of osteoclasts, and thus can be used for treating immune diseases, such as autoimmune disease, inflammatory disease, and transplant rejection diseases, which are caused by abnormal regulation of various kinds of immune responses.

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Номер записи: 2
06-11-2017 дата публикации

COMPOSITION COMPRISING COENZYME Q10 OR DERIVATIVES THEREOF FOR INHIBITING OR ALLEVIATING SIDE EFFECTS OF CYTOTOXICITY INDUCED BY CALCINEURIN INHIBITORS

Номер: KR1020170122573A
Автор: YANG, CHUL WOO, LIM, SUN WOO, YU, JI HYUN, CHO, MI LA
Принадлежит:

The present invention relates to a composition comprising coenzyme Q10 or derivatives thereof for inhibiting or alleviating side effects of cytotoxicity induced by calcineurin inhibitors and, more specifically, to a composition comprising coenzyme Q10 or derivatives thereof as active ingredients for inhibiting or alleviating side effects of fibrosis or apoptosis induced by tacrolimus or cyclosporine. The composition according to the present invention can be usefully used for developing medicines for preventing or alleviating cytotoxicity in kidney induced by calcineurin inhibitors, especially tacrolimus. COPYRIGHT KIPO 2017 ...

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Номер записи: 3
18-06-2020 дата публикации

COMPOSITION FOR DETECTING CARDIOVASCULAR DISEASES, AND KIT COMPRISING SAME

Номер: WO2020122406A1
Автор: YANG, Chul-Woo, CHUNG, Byung-Ha, KIM, Kyoung-Woon, KO, Eun Jeong, KIM, Bo-Mi
Принадлежит:

The present invention relates to a composition for predicting the onset or prognosis of cardiovascular diseases in a renal failure patient, especially, in an end-stage renal failure patient, by discovering a cardiovascular disease-associated gene marker specific to a renal failure patient, and a kit comprising same. By using, in a renal failure patient at high risk of cardiovascular diseases, a composition or a kit using a gene marker, provided in the present invention, the onset of cardiovascular diseases or prognosis in the early stages of cardiovascular diseases can be predicted, and appropriate therapy or treatment is possible before entering a stage of irreversible disease such as atherosclerosis.

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Номер записи: 4
21-07-2017 дата публикации

메트포민을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물

Номер: KR0101760510B1
Автор: 조미라, 양철우, 최종영, 박성환, 박민정, 이선영, 전주연, 이은정, 김재경, 김은경, 임선우
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 메트포민(metformin)을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 메트포민을 유효성분으로 포함하는 면역억제제로 유발된 신장 독성 감소용 조성물, 메트포민과 칼시뉴린 억제제(calcineurin inhibitor)를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 약학적 조성물 및 메트포민과 칼시뉴린 억제제를 구성요소로 포함하며 이들을 동시에, 개별적으로 또는 정해진 순서로 투여하는 것을 특징으로 하는 면역질환의 예방 또는 치료용 약학적 복합 제제에 관한 것이다. 본 발명의 조성물은 기존 면역억제제의 부작용으로 생기는 신장 기능 저하를 효과적으로 완화하여 면역억제가 필요한 질병의 치료 효과를 높이는데 유용하게 이용될 수 있으며, 더 나아가 기존의 면역억제제와 메트포민을 병용투여하는 다양한 방법을 제시하여 기존 면역억제제의 신장 독성 부작용은 줄이고, 면역억제 또는 면역조절 효과는 극대화함으로써, 장기이식 거부 반응, 자가면역질환, 염증성 질환 등을 예방하거나 치료하는데 유용하게 이용될 수 있다.

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Номер записи: 5
28-12-2015 дата публикации

COMPOSITION CONTAINING MESENCHYMAL STEM CELL TREATED WITH STAT3 INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING IMMUNE DISEASES

Номер: KR1020150144679A
Автор: CHO, MI LA, PARK, SUNG HWAN, YANG, CHUL WOO, PARK, MIN JUNG, YOUN, DEOK KYU, KIM, SEOK JUNG, LEE, SEON YEONG, LEE, EUN JUNG
Принадлежит:

The present invention relates to a composition containing a mesenchymal stem cell treated with a STAT3 inhibitor as an active ingredient for preventing or treating immune diseases. According to the present invention, the mesenchymal stem cell treated with a STAT3 inhibitor: can effectively control expression and generation of inflammatory cytokine and inflammation causing factors in a mesenchymal stem cell; has an effect for inhibiting a T cell from being differentiated into a cytotoxic Th17 cell and a cytotoxic Th1 cell if co-cultured with an undifferentiated T cell under an etiology condition; inhibits a function of an immune cell which is abnormally activated; and has an excellent effect of promoting differentiation and activity of the immunoregulatory T cell (Treg), which inhibits a function of an abnormally activated immune cell and controls inflammation reaction. Therefore, the mesenchymal stem cell treated with a STAT3 inhibitor can be used for a cell treatment agent composition ...

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Номер записи: 6
03-12-2018 дата публикации

METHOD FOR PRODUCING DUSTPROOF PAD

Номер: KR101924542B1
Автор: YANG, CHEL WOO
Принадлежит: YANG, CHEL WOO

The present invention relates to a method for producing a dustproof pad, and a dustproof pad thereby. More specifically, the present invention relates to a method for producing a dustproof pad which absorbs and blocks noise, vibration and the like by being placed in a building such as an apartment, a villa, and a shopping mall, or a floor, a wall, and a ceiling of a structure such as a subway, a railway, a tunnel, and a bridge. The present invention further relates to a dustproof pad thereby. COPYRIGHT KIPO 2019 (10) Primary mixing process (20) Secondary mixing process (30) Tertiary mixing process (40) First cooling process (50) Quaternary mixing process (60) Primary molding process (70) Primary drying process (80) Secondary forming process ...

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Номер записи: 7
18-07-2018 дата публикации

WATER EXPANDABLE RUBBER WATERSTOP MATERIAL AND MANUFACTURING METHOD THEREOF

Номер: KR1020180081894A
Автор: YANG, CHEL WOO
Принадлежит:

The present invention relates to a water expandable rubber waterstop material which prevents water from leaking between joints when being expanded by being in contact with water in a state of being fitted into a joint between primarily poured concrete and a secondarily poured concrete. The present invention blocks water introduced through a concrete joint by expanding between concrete joints when coming in contact with water while being fitted into a joint between primarily poured concrete and secondarily poured concrete. The present invention comprises: a body which prevents water from being introduced into a concrete joint by being expanded when coming in contact with water in a state of being fixed to concrete, which has a bar shape with a rectangular longitudinal cross-section and is primarily poured by a concrete nail, as a rubber material which is expanded when coming in contact with water; and a protrusion pad which is made of rubber material expanded when coming in contact with ...

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Номер записи: 8
14-05-2020 дата публикации

COMPOSITION FOR PREVENTING AND TREATING TRANSPLANT REJECTION OR TRANSPLANT REJECTION DISEASES, COMPRISING NOVEL COMPOUND AND CALCINEURIN INHIBITOR

Номер: WO2020096371A1
Автор: CHO, Mi-La, SHIN, Dong-Yun, CHOI, Jong-Young, YANG, Chul-Woo, PARK, Sung-Hwan, LEE, Seon-Yeong, PAKR, Min-Jung, JHUN, Joo-Yeon, KIM, Se-Young, SEO, Hyeon-Beom, RYU, Jae-Yoon, CHO, Keun-Hyung
Принадлежит:

The present invention relates to a composition for preventing and treating transplant rejection or transplant rejection diseases, the composition comprising a novel compound and a calcineurin inhibitor. A co-administration, of the present invention, with respect to an in vivo or in vitro syngeneic (allogenic) model, a transplant rejection disease model, a skin grafting model and a liver transplant patient, 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg, 3) has an effect of inhibiting side effects, such as tissue damage, occurring in a single administration, 4) inhibits various pathogenic pathways, 5) inhibits the death of inflammatory cells, and 6) increases the activity of mitochondria, and thus mitigates side effects possibly occurring in the single administration of conventional immunosuppressants, and inhibits transplant rejection. Thus, the present invention may be used in the field of pharmaceutics relating to transplant rejection ...

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Номер записи: 9
19-07-2018 дата публикации

MULTIPLE ANTI-VIBRATION DAMPING PADS AND METHOD FOR MANUFACTURING MULTIPLE VIBRATION DAMPING PADS

Номер: KR101880050B1
Автор: YANG, CHEL WOO
Принадлежит: YANG, CHEL WOO

The present invention relates to a multiple anti-vibration pad and a method for manufacturing an anti-vibration pad, wherein the anti-vibration pad has a structure in which a first pad and a second pad having different physical properties are stacked. To form the first pad and the second pad, natural rubber (NR) or ethylene-propylene rubber (EP), liquid isoprene rubber (LIR) or chloroprene rubber (CR), carbon black SRF (Semi-reinforcing Fumace Balck), calcium carbonate (cac03), compounded oil, zinc oxide (ZnO), stearic acid (S/T), M (MBT: 2-Mercapto benzo thiazole) of thiazole-based accelerators, TT (TMTD: Tetramethylthiuram Disulfide) of thiuram-based accelerators, sulfur (S), and cerium (CE) may be mixed. The anti-vibration pad of the present invention having the above-described components and structure is excellent in reducing external impact and vibration, has a small compression set, and has excellent aging resistance and heat resistance. COPYRIGHT KIPO 2018 ...

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Номер записи: 10
27-02-2018 дата публикации

코엔자임 큐텐 또는 이의 유도체를 포함하는 칼시뉴린 억제제로 유발되는 세포독성의 부작용 억제 또는 개선용 조성물

Номер: KR0101832900B1
Автор: 양철우, 임선우, 유지현, 조미라
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 코엔자임 큐텐(coenzyme Q10) 또는 이의 유도체를 포함하는 칼시뉴린 억제제(calcineurin inhibitor)로 유발되는 세포독성의 부작용 억제 또는 개선용 조성물에 대한 것으로, 보다 구체적으로는 코엔자임 큐텐(coenzyme Q10) 또는 이의 유도체를 유효성분으로 포함하는 타크로리무스 또는 사이클로스포린으로 유발되는 섬유화 또는 세포사멸의 부작용의 억제 또는 개선용 조성물에 대한 것이다. 본 발명에 따른 조성물은 칼시뉴린 억제제, 특히 타크로리무스의 부작용으로 유발되는 신장에서의 세포독성을 예방 또는 완화하는 의약품을 개발하는 데에 유용하게 이용될 수 있다.

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Номер записи: 11
19-02-2015 дата публикации

INFLAMMATION-CONTROLLING COMPOSITE AND STABILIZED MESENCHYMAL STEM CELLS HAVING OPTIMIZED IMMUNITY CONTROL FUNCTION BY BLOCKING STAT3 SIGNAL MOLECULE

Номер: WO2015023165A1
Автор: CHO, Mi-La, YANG, Chul-Woo, PARK, Min-Jung, LEE, Sung-Hee, LEE, Jeong-Ah, MUN, Yeong-Mi, SEO, Hyeon-Beom, KIM, Eun-Kyung, LEE, Seon-Yeong, PARK, Sung-Hwan, MOON, Su-Jin, KWOK, Seung-Ki, JEONG, Jeong-Hee, YANG, Eun-Ji, KIM, Seok-Jung, LEE, Eun-Jung
Принадлежит:

The present invention relates to stable sRAGE-overexpressed mesenchymal stem cells having an excellent immunity control function and a cell-treatment agent composition containing same for preventing or treating immune disease. Also, the present invention relates to: a method for preparing mesenchymal stem cells capable of mass-producing human transforming growth factor-beta (TGF-β) and having the immunity control function, comprising a step of treating, with metformin, a mesenchymal stem cell having immunological characteristics of positive CD105, DC29, and CD44 and negative CD34, CD45, and HLA-DR, and cultivating same for 14 to 21 days at a temperature of 28 to 42℃; mesenchymal stem cells prepared by the method; and the cell-treatment agent composition containing the mesenchymal stem cells for treating or preventing immune disease.

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Номер записи: 12
23-09-2016 дата публикации

메트포민이 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물

Номер: KR0101659158B1
Автор: 조미라, 양철우, 박성환, 문수진, 곽승기, 박민정, 이선영, 이성희, 정정희, 양은지, 김은경, 김석중, 이은정
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 CD105, CD29 및 CD44는 양성이며 CD34, CD45 및 HLA-DR는 음성의 면역학적 특징을 갖는 간엽줄기세포에 메트포민을 처리하여, 28~42℃의 온도에서 14 ~ 21일 동안 배양하는 단계를 포함하는, 인간형질전환 성장인자-베타(TGF-β)를 대량생산하고 면역조절능을 갖는 간엽줄기세포의 제조방법 및 상기 방법으로 제조된 간엽줄기세포, 상기 간엽줄기세포를 함유하는 면역질환 치료 또는 예방용 세포치료제 조성물에 관한 것이다. 본 발명에 따른 메트포민이 처리된 면역조절능을 갖는 간엽줄기세포는 면역조절능을 갖는 인자인 IDO, TGF-beta 또는 IL-10의 발현이 증가되어 있고, 자가포식작용 및 미토콘드리아 활성을 증가되어 있어 면역질환 치료를 위한 세포치료제로 유용하게 사용할 수 있는 효과가 있다.

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Номер записи: 13
25-09-2015 дата публикации

COMPLEX COMPOSITION COMPRISING METFORMIN, COENZYME Q10 AND STATIN AND USE FOR PREVENTING OR TREATING IMMUNE DISEASE

Номер: KR1020150108298A
Автор: CHO, MI LA, PARK, SUNG HWAN, YANG, CHUL WOO, LEE, SEON YEONG, PARK, MIN JUNG, YANG, EUN JI, SON, HYE JIN, LEE, SUNG HEE, LEE, JEONG AH, JHUN, JOO YEON, JEONG, JEONG HEE, LEE, EUN JUNG, NA, HYUN SIK
Принадлежит:

The present invention relates to a pharmaceutical use of metformin, coenzyme Q10 and statin used in preventing or treating an immune disease caused by disorder of immunization and, more specifically, to a pharmaceutical composition for preventing or treating an immune disease containing metformin, coenzyme Q10 and statin as active components. The treatement of immune disease by co-administration of metformin, coenzyme Q10 and statin according to the present invention controlls expression of TNF-a, IL-17, Th1 and/or Th17 which are inflammatory cytokine compared with a group independently treating metformin, coenzyme Q10 and statin. and effectively treating the immune diseases in a joint inflammation induced animal model, and inflammatory intestine disease-induced animal model. COPYRIGHT KIPO 2015 ...

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Номер записи: 14
02-08-2016 дата публикации

MESENCHYMAL STEM CELLS OVEREXPRESSING GRIM19 FOR TREATING IMMUNE DISEASES AND USE THEREOF

Номер: KR1020160091236A
Автор: CHO, MI LA, KIM, SEOK JUNG, YANG, CHUL WOO, PARK, SUNG HWAN, PARK, MIN JUNG, LEE, SEON YEONG, LEE, EUN JUNG
Принадлежит:

The present invention relates to a cell therapeutic agent composition for treating immune diseases, more specifically, to a composition for preventing or treating immune disease comprising, as an active ingredient, mesenchymal stem cells genetically modified by a recombinant vector containing the GRIM19 gene. According to the present invention, the mesenchymal stem cells genetically modified by a recombinant vector containing the GRIM19 gene can suppress the expression and production of inflammatory cytokines and proinflammatory factors, and when co-cultured with undifferentiated T cells under pathological conditions, has the effect of suppressing the differentiation of T cells into cytotoxic Th17 and Th1 cells, and has an excellent effect of promoting the differentiation and activity of immunoregulatory T cells (Treg) that have the characteristic of suppressing the function of abnormally activated immune cells and controlling inflammatory responses. Further, the mesenchymal stem cells ...

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Номер записи: 15
17-10-2018 дата публикации

메트포민을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물

Номер: KR0101909269B1
Автор: 조미라, 양철우, 최종영, 박성환, 박민정, 이선영, 전주연, 이은정, 김재경, 김은경, 임선우
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 메트포민(metformin)을 포함하는 면역억제제로 인한 신장 독성 완화용 조성물 및 이를 포함하는 면역질환 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 메트포민을 유효성분으로 포함하는 면역억제제로 유발된 신장 독성 감소용 조성물, 메트포민과 칼시뉴린 억제제(calcineurin inhibitor)를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 약학적 조성물 및 메트포민과 칼시뉴린 억제제를 구성요소로 포함하며 이들을 동시에, 개별적으로 또는 정해진 순서로 투여하는 것을 특징으로 하는 면역질환의 예방 또는 치료용 약학적 복합 제제에 관한 것이다. 본 발명의 조성물은 기존 면역억제제의 부작용으로 생기는 신장 기능 저하를 효과적으로 완화하여 면역억제가 필요한 질병의 치료 효과를 높이는데 유용하게 이용될 수 있으며, 더 나아가 기존의 면역억제제와 메트포민을 병용투여하는 다양한 방법을 제시하여 기존 면역억제제의 신장 독성 부작용은 줄이고, 면역억제 또는 면역조절 효과는 극대화함으로써, 장기이식 거부 반응, 자가면역질환, 염증성 질환 등을 예방하거나 치료하는데 유용하게 이용될 수 있다.

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Номер записи: 16
06-11-2015 дата публикации

NOVEL COMPOUND WITH EFFECTS OF TREATING IMMUNE DISEASE AND USE THEREOF

Номер: KR1020150124880A
Автор: CHO, MI LA, SHIN, DONG YUN, PARK, SUNG HWAN, YANG, CHUL WOO, CHOI, JONG YOUNG, PARK, MIN JUNG, SON, HYE JIN, LEE, SUNG HEE, LEE, SEON YEONG
Принадлежит:

The present invention relates to a novel compound capable of effectively treating and preventing immune disease and to a use thereof. The novel compound of the present invention suppresses the production of inflammatory cytokines and increases activities of regulatory T cells having immune regulatory ability. In addition, the compound of the present invention controls over an excessive immune response by inhibiting the production of autoantibodies and differentiation of osteoclasts, thereby being able to be used for treating immune diseases induced by regulatory anomalies of various immune response such as autoimmune disease, inflammatory diseases, and transplant rejection. COPYRIGHT KIPO 2016 (a) Cell toxicity effect control(MTT assay) (AA) Normal mouse cell (b) Autoantibody production immune reaction control (c) Inflammatory cytokine production control (d) Inflammatory gene expression control ...

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Номер записи: 17
26-02-2015 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING BIGUANIDE DERIVATIVE COMPOUND AS ACTIVE INGREDIENT

Номер: WO2015026215A9
Автор: CHO, Mi-La, YANG, Chul-Woo, SHIN, Dong-Yun, PARK, Min-Jung, LEE, Seon-Yeong, LEE, Sung-Hee, YANG, Eun-Ji, SON, Hye-Jin, KIM, Eun-Kyung, KIM, Jae-Kyung
Принадлежит:

The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.

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Номер записи: 18
22-02-2019 дата публикации

수팽창 고무 지수재 및 이의 제조 방법

Номер: KR0101951536B1
Автор: 양철우
Принадлежит: 양철우

... 본 발명은 1차 타설된 콘크리트와, 2차 타설된 콘크리트 사이의 이음매에 끼워진 상태에서 물과 접촉되었을 때 팽창됨에 따라 이음매 사이로 물이 새지 않도록 한 수팽창 고무 지수재에 관한 것으로, 1차 타설된 콘크리트와, 2차 타설된 콘크리트 사이의 이음매에 끼워진 상태에서 물과 접촉되었을 때 콘크리트 이음매 사이에서 팽창됨으로써 콘크리트 이음매를 통해 유입되는 물을 차단하는 수팽창 고무 지수재에 있어서, 물과 접촉되었을 때 팽창되는 고무 재질로서 바(Bar) 형태이고 종단면이 사각 형태이며 콘크리트 못에 의해 1차 타설된 콘크리트에 고정된 상태에서 물과 접촉되었을 때 팽창됨으로서 콘크리트 이음매 안으로 물이 유입됨을 방지하는 몸체와; 물과 접촉되었을 때 팽창되는 고무 재질로서 종단면이 사각 형태이고 몸체의 윗면으로부터 돌출되며 종방향으로 잘랐을 때 종단면이 몸체의 종단면보다 작으며 몸체와 일체로 결합 되어 물과 접촉되었을 때 팽창되어 콘크리트 이음매 안으로 물이 유입됨을 1차적으로 방지함과 동시에 콘크리트 못에 끼워지는 고무 패킹이나 고무 와샤를 대신하며 콘크리트 못이 박히는 돌출 패드로 이루어져, 몸체와 돌출 패드를 1차 타설된 콘크리트 위에 고정 시킬 때 콘크리트 못에 고무 와샤나 고무 패킹을 끼울 필요 없이 직접 돌출 패드에 콘크리트 못을 박아 몸체와 돌출 패드를 1차 타설된 콘크리트에 고정시킨다.

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Номер записи: 19
06-11-2015 дата публикации

NOVEL COMPOUND WITH EFFECTS OF TREATING IMMUNE DISEASE AND USE THEREOF

Номер: KR1020150124923A
Автор: CHO, MI LA, SHIN, DONG YUN, PARK, SUNG HWAN, YANG, CHUL WOO, CHOI, JONG YOUNG, PARK, MIN JUNG, SON, HYE JIN, LEE, SUNG HEE, LEE, SEON YEONG, KIM, EUN KYUNG, KIM, JAE KYUNG, LEE, SEUNG HUN, PARK, SEONG HYEOK
Принадлежит:

The present invention relates to a novel compound capable of effectively treating and preventing immune disease and to a use thereof. The novel compound of the present invention suppresses the production of inflammatory cytokines and increases activities of regulatory T cells having immune regulatory ability. In addition, the compound of the present invention controls over an excessive immune response by inhibiting the production of autoantibodies and differentiation of osteoclasts, thereby being able to be used for treating immune diseases induced by regulatory anomalies of various immune response such as autoimmune disease, inflammatory diseases, and transplant rejection. COPYRIGHT KIPO 2016 (a) Cell toxicity effect control(MTT assay) (AA) Normal mouse cell (b) Autoantibody production immune reaction control (c) Inflammatory cytokine production control (d) Inflammatory gene expression control ...

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Номер записи: 20
26-02-2015 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING BIGUANIDE DERIVATIVE COMPOUND AS ACTIVE INGREDIENT

Номер: WO2015026215A1
Автор: CHO, Mi-La, YANG, Chul-Woo, SHIN, Dong-Yun, PARK, Min-Jung, LEE, Seon-Yeong, LEE, Sung-Hee, YANG, Eun-Ji, SON, Hye-Jin, KIM, Eun-Kyung, KIM, Jae-Kyung
Принадлежит:

The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.

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Номер записи: 21
28-08-2015 дата публикации

MEDIUM COMPOSITION FOR CULTURING CELLS AND CULTURE METHOD USING SAME

Номер: KR1020150098557A
Автор: CHO, MI LA, PARK, SUNG HWAN, SHIN, DONG YUN, PARK, MIN JUNG, LEE, SUNG HEE, LEE, JEONG AH, LEE, EUN JUNG, YANG, CHUL WOO
Принадлежит:

The present invention relates to a medium composition for culturing cells and a culture method using the same and, more specifically, to a medium composition for culturing cells, containing a daurinol compound, and to a culture method using the same. Compared to a conventional culture medium, when culturing undifferentiated T cells, the medium composition for culturing cells, containing a daurinol compound according to the present invention promotes differentiation of undifferentiated T cells into regulatory T cells (Treg) and an activity thereof; is suitable for use in a culture medium for treatment of immune disorders due to the effect of greatly inhibiting differentiation into Th17 cells and an activity thereof; and is capable of keeping activities of cells (cells with immune regulatory properties) for treatment of immune disorders for a long period of time. COPYRIGHT KIPO 2015 ...

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Номер записи: 22
26-07-2017 дата публикации

세포 배양용 배지 조성물 및 배양 방법

Номер: KR0101757032B1
Автор: 조미라, 박성환, 신동윤, 박민정, 이성희, 이정아, 이은정, 양철우
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 세포 배양 배지 조성물 및 이를 이용한 세포 배양 방법에 관한 것으로 보다 구체적으로는 다우리놀 화합물을 포함하는 세포 배양 배지 조성물 및 이를 이용한 세포 배양 방법에 관한 것이다. 본 발명에 따른 다우리놀이 첨가된 세포 배양 배지 조성물은 기존의 세포 배양 배지에 비해 미분화 T 세포를 배양할 경우, 미분화 T 세포가 조절 T 세포(Regulatory T cell: Treg)로 분화 및 활성이 촉진되고, Th17 세포로의 분화 및 활성은 억제시키는 효과가 커서 면역질환 치료용 세포 배양 배지로 사용이 적합하며, 면역질환 치료를 위한 세포(면역조절능을 갖는 세포)를 장시간 활성을 유지하게 할 수 있는 효과가 있다.

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Номер записи: 23
23-12-2015 дата публикации

COMPOSITION COMPRISING MESENCHYMAL STEM CELLS TREATED WITH STAT3 INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING IMMUNE DISEASES

Номер: WO2015194710A1
Автор: CHO, Mi-La, PARK, Sung-Hwan, YANG, Chul-Woo, PARK, Min-Jung, YOUN, Deok-Kyu, KIM, Seok-Jung, LEE, Seon-Yeong, LEE, Eun-Jung
Принадлежит:

The present invention relates to a cell therapeutic composition including mesenchymal stem cells, which have been treated with an STAT3 inhibitor, as an active ingredient for preventing or treating immune diseases. The mesenchymal stem cells treated with an STAT3 inhibitor according to the present invention are characterized by: being capable of effectively suppressing the expression and production of inflammatory cytokines and inflammation inducing agents in mesenchymal stem cells; having an effect of inhibiting the differentiation of T cells into cytotoxic Th17 and Th1 cells during co-culture with undifferentiated T cells under a disease-causing condition; and having an excellent effect of promoting differentiation and activity of immunoregulatory T cells (Treg) having the properties of suppressing a function of abnormally activated immunological cells and controlling an inflammatory response. Thus, the mesenchymal stem cells treated with an STAT3 inhibitor can be used as a cell therapeutic ...

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Номер записи: 24
27-08-2015 дата публикации

MEDIUM COMPOSITION FOR CELL CULTURE AND CULTURE METHOD

Номер: WO2015126046A1
Автор: CHO, Mi La, PARK, Sung Hwan, SHIN, Dong Yun, PARK, Min Jung, LEE, Sung Hee, LEE, Jeong Ah, LEE, Eun Jung, YANG, Chul Woo
Принадлежит:

The present invention relates to a medium composition for cell culture and a cell culture method using the same. More specifically, the present invention relates to a medium composition for cell culture comprising a daurinol compound and a cell culture method using the same. When culturing an undifferentiated T cell, compared to a conventional cell culture medium, the medium composition for cell culture to which daurinol is added according to the invention promotes the differentiation of the undifferentiated T cell into a regulatory T cell (Treg) and the activity thereof; is suitable for use as a cell culture medium for treating immune diseases since the composition is largely effective in inhibiting the differentiation into Th17 cell and the activity thereof; and is effective in allowing the cell to maintain activity for a long time for treating immune diseases.

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Номер записи: 25
02-06-2016 дата публикации

Composition for preventing or treating autoimmune disease comprising metformin and statin

Номер: KR0101627045B1
Автор: 조미라, 박성환, 박민정, 전주연, 이성희, 변재경, 정정희, 이정아, 곽승기, 이주하, 주지현, 양철우, 나현식, 이은정
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 메트포민 및 스타틴의 복합제를 이용한 자가면역질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 메트포민 및 스타틴을 유효성분으로 포함하는 복합제인 자가면역질환의 예방 또는 치료용 약학적 조성물은 염증성 사이토카인의 생성을 효과적으로 억제시킬 수 있고, 항체 생산 B 세포의 생성을 저해 또는 활성을 감소시킬 수 있으며, 파골세포의 분화를 억제하고 관절파괴를 억제하는 효과를 가지며 동맥경화반(Artherosclerotic plaque) 전구세포를 형성하는 거품세포(Foam cell)의 생성 억제 효과가 뛰어나 메트포민 및 스타틴을 유효성분으로 하는 복합제는 자가면역질환의 치료제로서 매우 유용하게 활용될 수 있다.

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Номер записи: 26
04-04-2017 дата публикации

mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물

Номер: KR0101723265B1
Автор: 양철우, 조미라, 박성환, 문수진, 김은경, 정병하, 김경운, 이선영, 이성희, 양은지, 정정희, 박민정, 김석중, 이은정
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역조절능을 갖는 간엽줄기세포 및 이의 제조방법에 관한 것으로, 보다 구체적으로 라파마이신이 처리된 면역조절능을 갖는 간엽줄기세포에 있어서; CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 및 CXCR4로 이루어진 군으로부터 선택되는 어느 하나 이상의 세포 표면인자가 발현되는 간엽줄기세포, 상기 간엽줄기세포를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물 및 면역조절능을 갖는 간엽줄기세포의 제조방법에 관한 것이다. 본 발명에 따른 라파마이신(rapamycin)이 처리된 면역조절능을 갖는 간엽줄기세포는 면역조절능을 갖는 인자인 IDO, TGF-beta 및 IL-10의 발현이 증가되어 있고, mTOR의 신호전달 인자인 Phospho-mTOR, Rictor 및 Ractor의 발현은 감소되어 있으며, 자가포식 유도인자인 Beclin1, ATG5, ATG7, LC3I 또는 LCII의 발현이 상기 세포 내에서 증가되어 있는 세포로서, 이 세포를 면역질환 개체에 세포치료제로 사용하는 경우, 효과적으로 면역질환을 치료할 수 있는 효과가 있다.

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Номер записи: 27
06-03-2017 дата публикации

METFORMIN-CONTAINING COMPOSITION FOR PREVENTING OR TREATING MITOCHONDRIAL DISEASES CAUSED BY IMMUNO-SUPPRESSIVE DRUGS AND IMMUNE DISEASES

Номер: KR1020170023724A
Автор: CHO, MI LA, YANG, CHUL WOO, PARK, SUNG HWAN, LEE, SEON YEONG, PARK, MIN JUNG, JHUN, JOO YEON, LIM, SUN WOO, CHUNG, BYUNG HA, KIM, EUN KYUNG, KIM, JAE KYUNG, NA, HYUN SIK, KIM, SE YOUNG, LEE, EUN JUNG, SEO, HYEON BEOM
Принадлежит:

The present invention relates to a metformin-containing composition for preventing or treating mitochondrial diseases caused by immuno-suppressive drugs and immune diseases. More particularly, the present invention relates to a metformin-containing composition for treating mitochondrial diseases caused by immuno-suppressive drugs, a pharmaceutical composition comprising metformin and an immuno-suppressive drug which is a rapamycin-targeted inhibitor (mTOR inhibitor) as an active ingredient for preventing or treating immune diseases, and a pharmaceutical complex formulation comprising metformin and a mammal rapamycin-targeted inhibitor as ingredients administered simultaneously or individually or in a predetermined order for preventing or treating immune diseases. The composition according to the present invention effectively alleviates mitochondrial damage caused by side effects of the conventional immuno-suppressive drugs, improves the effect of immuno-suppressive therapy, and thus is ...

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Номер записи: 28
20-09-2017 дата публикации

METFORMIN-COMPRISING COMPOSITIONS FOR PREVENTING OR TREATING MITOCHONDRIAL DISEASES CAUSED BY IMMUNOSUPPRESSIVE DRUGS AND IMMUNE DISEASES

Номер: KR1020170106283A
Автор: CHO, MI LA, YANG, CHUL WOO, PARK, SUNG HWAN, LEE, SEON YEONG, PARK, MIN JUNG, JHUN, JOO YEON, LIM, SUN WOO, CHUNG, BYUNG HA, KIM, EUN KYUNG, KIM, JAE KYUNG, NA, HYUN SIK, KIM, SE YOUNG, LEE, EUN JUNG, SEO, HYEON BEOM
Принадлежит:

The present invention relates to metformin-comprising compositions for preventing or treating mitochondrial diseases caused by immunosuppressive drugs and immune diseases. More particularly, the present invention relates to a pharmaceutical composition for preventing or treating immune diseases. The pharmaceutical composition includes a composition comprising metformin for treating mitochondrial diseases caused by immunosuppressive drugs, a pharmaceutical composition for preventing or treating an immunological disease comprising an immunosuppressive drug which is metformin and rapamycin target inhibitor (mTOR inhibitor) as an active ingredient, and metformin and a mammal rapamycin target inhibitor. They may be administered simultaneously, individually or in a predetermined order. The composition of the present invention effectively alleviates the functional impairment of mitochondria caused by the side effects of conventional immunosuppressive drugs and further improves an immunosuppressive ...

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Номер записи: 29
31-08-2018 дата публикации

비휘발성 메모리 장치 및 프로그램 방법과 이를 이용하는 데이터 처리 시스템

Номер: KR0101893864B1
Автор: 양철우
Принадлежит: 에스케이하이닉스 주식회사

... 프로그램 시간을 최적화할 수 있는 비휘발성 메모리 장치 및 프로그램 방법과 이를 이용하는 데이터 처리 시스템에 관한 것으로, 본 기술의 일 실시예에 의한 비휘발성 메모리 장치는 워드라인 및 비트라인 간에 접속되는 복수의 메모리 셀을 포함하는 메모리 셀 영역, 프로그램 명령 및 어드레스 신호에 응답하여 특정 워드라인이 선택됨에 따라, 선택된 워드라인에 대한 프로그램 전압 인가 시간을 결정하는 프로그램 타임 제어부 및 프로그램 타임 제어부에서 결정된 프로그램 전압 인가 시간에 따라 워드라인으로 프로그램 전압을 인가하도록 제어하는 컨트롤러를 포함할 수 있다.

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Номер записи: 30
12-10-2017 дата публикации

NOVEL USE OF COMPOSITION CONTAINING KLOTHO IN TACROLIMUS-INDUCED RENAL CELLULAR TOXICITY

Номер: KR1020170111384A
Автор: YANG, CHUL WOO, LIM, SUN WOO
Принадлежит:

The present invention relates to a pharmaceutical composition for inhibiting tacrolimus-induced renal toxicity, or preventing or treating mitochondrial diseases containing a composition comprising Klotho as an active ingredient. The Klotho compound shows a protection effect with respect to mitochondria damage in renal cells induced by tacrolimus which is an immunosuppressant, thereby improving renal functions. Accordingly, the Klotho compound can be used as a transplant disease medicine as an antiaging functional agent and is effective in mitochondria-related diseases. COPYRIGHT KIPO 2017 ...

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Номер записи: 31
25-07-2016 дата публикации

바이구아나이드 유도체 화합물을 유효성분으로 포함하는 면역질환 또는 염증질환의 예방 또는 치료용 약제학적 조성물

Номер: KR0101642587B1
Автор: 조미라, 양철우, 신동윤, 박민정, 이선영, 이성희, 양은지, 손혜진, 김은경, 김재경
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역질환을 효과적으로 예방 및 치료할 수 있는 바이구아나이드(biguanide) 유도체 화합물에 관한 것이다. 본 발명의 바이구아나이드계 유도체 화합물은 염증성 사이토카인인 IL-17 및 TNF-α의 생성을 억제시키며, 면역조절 기능을 갖는 조절 T 세포의 활성을 증대시킬 뿐만 아니라, 면역질환 동물모델에 대해 우수한 치료 효과를 나타낸다. 따라서 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 약학적 조성물 또는 면역 억제제로 유용하게 사용될 수 있다.

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Номер записи: 32
06-08-2020 дата публикации

COMPOSITION COMPRISING MLS-STAT3 FOR PREVENTION OR TREATMENT OF IMMUNE DISEASE

Номер: WO2020159191A1
Автор: CHO, Mi-La, PARK, Sung-Hwan, LEE, Seon-Yeong, MOON, Su-Jin, KIM, Eun-Kyung, RYU, Jun-Geol, CHOI, Si-Yeong, CHOI, Jeong-Won, JUNG, Kyung-Ah, LEE, A-Ram, YANG, Chul-Woo, MOON, Jeong-Hyeon
Принадлежит:

The present invention relates to: a recombinant peptide in which a Mitochondria Localization Sequence (MLS) peptide and the Signal Transducer and Activator of Transcription 3 (STAT3) are fused to each other; a recombinant vector carrying a polynucleotide coding for the recombinant peptide; and a composition comprising the recombinant peptide or the recombinant vector as an active ingredient for prevention or treatment of autoimmune disease or inflammatory disease, wherein the recombinant peptide or the recombinant vector allows STAT3 to be overexpressed in the mitochondria to enhance the mitochondrial function, resulting in inhibiting the expression of inflammatory cytokines including IL-17, whereby the composition can be advantageously used for preventing or treating autoimmune disease or inflammatory diseases.

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Номер записи: 33
28-06-2016 дата публикации

COMPOSITION COMPRISING METFORMIN FOR ALLEVIATING NEPHROTOXICITY CAUSED BY IMMUNOSUPPRESSIVE DRUG AND COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES COMPRISING SAME

Номер: KR1020160074415A
Автор: CHO, MI LA, YANG, CHUL WOO, CHOI, JONG YOUNG, PARK, SUNG HWAN, PARK, MIN JUNG, LEE, SEON YEONG, JHUN, JOO YEON, LEE, EUN JUNG, KIM, JAE KYUNG, KIM, EUN KYUNG, LIM, SUN WOO
Принадлежит:

The present invention relates to a composition comprising metformin for alleviating nephrotoxicity caused by an immunosuppressive drug and a composition for preventing or treating immune diseases comprising the same. More particularly, the present invention relates to a composition for reducing nephrotoxicity caused by an immunosuppressive drug, which comprises metformin as an active ingredient, a pharmaceutical composition for preventing or treating immune diseases, which comprises metformin and a calcineurin inhibitor as active ingredients, and a pharmaceutical complex formulation for preventing or treating immune diseases, which comprises metformin and a calcineurin inhibitor as active ingredients, administered simultaneously, individually or sequentially in a predetermined order. The composition according to the present invention effectively alleviates malfunction of the kidney caused by the side effect of a conventional immunosuppressive drug and is useful for increasing the effect ...

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Номер записи: 34
18-06-2020 дата публикации

COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING MESENCHYMAL STEM CELLS DERIVED FROM DEDIFFERENTIATED STEM CELLS

Номер: WO2020122405A1
Автор: YANG, Chul-Woo, CHUNG, Byung-Ha, KIM, Kyoung-Woon, KIM, Bo-Mi
Принадлежит:

The present invention provides a pharmaceutical composition for preventing or treating autoimmune diseases or inflammatory diseases, comprising mesenchymal stem cells (iPS-MSC) derived from pluripotent stem cells produced from somatic cells, or a conditioned medium thereof. The pharmaceutical composition provided in the present invention exhibits superior immunoregulatory and anti-inflammatory effects compared to mesenchymal stem cells directly isolated from tissues, and can be easily supplied, and thus is effective for preventing and treating autoimmune diseases such as rheumatoid arthritis.

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Номер записи: 35
28-07-2016 дата публикации

MESENCHYMAL STEM CELLS OVER-EXPRESSED BY GRIM19 EFFICACIOUS IN TREATING IMMUNE DISEASE, AND USE THEREOF

Номер: WO2016117960A1
Автор: CHO, Mi La, KIM, Seok Jung, YANG, Chul Woo, PARK, Sung Hwan, PARK, Min Jung, LEE, Seon Yeong, LEE, Eun Jung
Принадлежит:

The present invention relates to a cell therapeutic agent composition for preventing or treating an immune disease, the composition comprising, as an active ingredient, mesenchymal stem cells genetically modified by a recombinant vector containing the GRIM19 gene. According to the present invention, the mesenchymal stem cells genetically modified by a recombinant vector containing the GRIM19 gene can suppress the expression and production of inflammatory cytokines and proinflammatory factors, and have the ability, when co-cultured with undifferentiated T cells under pathological conditions, to promote the differentiation and activity of immunoregulatory T cells (Treg) that have the characteristic of suppressing differentiation of T cells into cytotoxic Th17 and Th1 cells, and of controlling inflammatory responses, and, in addition, to move rapidly and accurately to a pathologically affected site, and thus the mesenchymal stem cells genetically modified by a recombinant vector containing ...

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Номер записи: 36
09-02-2017 дата публикации

STAT3 억제제가 처리된 간엽줄기세포를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물

Номер: KR0101705412B1
Автор: 조미라, 박성환, 양철우, 박민정, 윤덕규, 김석중, 이선영, 이은정, 김재경, 나현식, 이승훈
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 STAT3 억제제가 처리된 간엽줄기세포를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물에 관한 것이다. 본 발명에 따른 STAT3 억제제가 처리된 간엽줄기세포는 간엽줄기세포에서의 염증성 사이토카인 및 염증 유발인자의 발현과 생성을 효과적으로 억제할 수 있고, 병인조건 하에서 미분화 T 세포와 공조 배양할 경우, T 세포의 세포 독성 Th17 및 Th1 세포로의 분화를 억제하는 효과가 있으며, 비정상적으로 활성화된 면역세포의 기능을 억제하고 염증 반응을 제어하는 특성을 갖는 면역조절 T 세포(Treg)의 분화 및 활성을 증진시키는 효과가 우수한 특징이 있다. 따라서 STAT3 억제제가 처리된 간엽줄기세포는 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 세포치료제 조성물로 사용할 수 있는 효과가 있다.

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Номер записи: 37
11-05-2017 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SKIN DISEASES COMPRISING METFORMIN AS ACTIVE INGREDIENT

Номер: KR1020170050540A
Автор: CHO, MI LA, PARK, SUNG HWAN, YANG, CHUL WOO, LEE, SEON YEONG, PARK, MIN JUNG, YOO, JIN HEE, MOON, SU JIN, LEE, EUN JUNG, JUNG, KYUNG AH, KIM, EUN KYUNG, JHUN, JOO YEON
Принадлежит:

The present invention relates to a composition capable of effectively treating skin disease including psoriasis or scleroderma. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating skin disease including metformin as an active ingredient. According to the present invention, the composition including metformin reduces erythema, dead skin cells, and epidermal thickness, inhibits expression of IL-17, IL-6, which are inflammatory cytokines, and STAT3, alleviates damage to epidermal tissue, and, consequently, can treat psoriasis in an effective manner. In addition, the composition inhibits activity of fibrosis, inhibits expression of IL-17, IL-6, which are inflammatory cytokines, and expression of Th17 cell, inhibits COLI1a and TGF-β genes, which are representative transcriptors of fibrosis, and thus can effectively treat scleroderma. COPYRIGHT KIPO 2017 ...

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Номер записи: 38
12-05-2016 дата публикации

COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES, COMPRISING TACROLIMUS AND VITAMIN D AS ACTIVE INGREDIENT

Номер: KR1020160052220A
Автор: YANG, CHUL WOO, CHO, MI LA, CHUNG, BYUNG HA, KIM, KYOUNG WOON, YANG, WON MI, DOH, KYOUNG CHAN, KIM, BO MI
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune diseases, comprising tacrolimus and vitamin D as an active ingredient. According to the present invention, the tacrolimus and the vitamin D have excellent effects in inhibiting the differentiation into cytotoxic Th17 cells for generating and secreting inflammatory cytokine. Therefore, the tacrolimus and the vitamin D can be efficiently used as an immunosuppressive agent or a pharmaceutical composition for preventing or treating immune diseases such as autoimmune diseases, inflammatory diseases, and transplant rejection, which are generated by abnormal control of various immune responses. COPYRIGHT KIPO 2016 ...

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Номер записи: 39
30-10-2018 дата публикации

COMPOSITION FOR PREVENTING OR TREATING IMMUNOLOGICAL DISEASE COMPRISING ALPHA LIPOIC ACID AND METFORMIN AS ACTIVE INGREDIENT

Номер: KR1020180117913A
Автор: CHO, MI LA, YANG, CHUL WOO, PARK, SUNG HWAN, JHUN, JOO YEON, KWON, JEONG EUN, LEE, SEUNG HOON, LEE, SEON YEONG, KIM, SE YOUNG, SEO, HYEON BEOM
Принадлежит:

The present invention relates to pharmaceutical use of alpha-lipoic acid and metformin capable of preventing or treating immune diseases caused by abnormality of an immune response. The alpha-lipoic acid and metformin according to the present invention have activity of inhibiting production and secretion of inflammatory cytokines and inhibit STAT3 expression or activity. Therefore, the composition can be effectively used as an active ingredient of a pharmaceutical composition or health functional food which can prevent or treat the immune diseases such as autoimmune diseases, inflammatory diseases and graft rejection diseases caused by abnormalities of various immune responses. COPYRIGHT KIPO 2018 ...

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Номер записи: 40
25-06-2020 дата публикации

NOVEL CYTOKINES AND USE THEREOF

Номер: WO2020130711A1
Автор: CHO, Mi-La, YANG, Chul-Woo, PARK, Sung-Hwan, LEE, Seon-Yeong, MOON, Young-Mee, KWOK, Seung-Ki, SEO, Hyeon-Beom, RYU, Jun-Geol, KIM, Eun-Kyung
Принадлежит:

The present invention relates to a novel composite that is formed by linking subunit p40 and subunit EBI3 via a linker and has excellent anti-inflammatory effects and immunomodulatory effects.

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Номер записи: 41
14-11-2013 дата публикации

KIT FOR MONITORING IMMUNE STATUS AFTER TRANSPLANT AND MONITORING METHOD USING SAME

Номер: WO2013168876A1
Автор: YANG, Chul-Woo, CHO, Mi-La, CHOI, Jong-Young, JHUN, Joo-Yeon, KIM, Hee-Yeon, BYUN, Jae-Kyeong, YIM, Ye-Been, CHUNG, Byung-Ha, KIM, Kyoung-Won
Принадлежит:

The present invention relates to a method and kit for monitoring an immune status after a transplant. According to the kit for monitoring an immune status after a transplant and the method for monitoring the immune status of an individual after a transplant of the present invention, the immune status of an individual after a transplant can be determined with ease and accuracy, and thus excessive use of an immunosuppressant prescribed after transplantation can be prevented and the immune status of each patient can be managed.

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Номер записи: 42
24-05-2017 дата публикации

조절 Ｔ 세포의 분화 가변성을 억제하는 탄시논 ⅡＡ의 신규 용도

Номер: KR0101739601B1
Автор: 양철우, 조미라, 이선영, 문영미, 허양미, 손혜진, 유준걸
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 조절 T 세포(Treg)의 분화 가변성을 억제하는 탄시논(Tanshinone) IIA 화합물의 신규 용도에 관한 것으로, 자세하게는 탄시논 IIA 화합물을 유효성분으로 함유하는 조절 T 세포(Treg)의 Th17 세포로의 분화 억제용 조성물; 탄시논 IIA 화합물 및 조절 T 세포(Treg)를 유효성분으로 함유하는 면역질환의 예방 또는 치료용 조성물 및 탄시논 IIA 화합물을 이용한 면역억제 기능이 유지되는 조절 T 세포(Treg) 제조방법에 관한 것이다. 본 발명에 따른 탄시논 IIA 화합물은 조절 T 세포(Treg)의 Th17 세포로의 분화가변성(plasticity)을 억제하는 활성을 통하여 조절 T 세포(Treg)로서의 기능을 효과적으로 유지 및 강화시키는 신규 용도를 가지므로, 이를 조절 T 세포(Treg)와 함께 병행하여 사용하는 경우, 병적 환경 하에서도 조절 T 세포(Treg)의 Th17 세포로의 분화를 차단할 수 있어 보다 효과적인 면역질환 치료를 위한 치료제를 제공할 수 있는 효과가 있다.

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Номер записи: 43
12-02-2016 дата публикации

USES FOR INHIBITING CYTOTOXICITY BY TACROLIMUS OF DIPEPTIDYL PEPTIDASE 4 INHIBITOR

Номер: KR1020160014887A
Автор: YANG, CHUL WOO, LIM, SUN WOO, JIN LONG
Принадлежит:

The present invention relates to novel uses for inhibiting cytotoxicity by tacrolimus as an immunosuppressive agent of a dipeptidyl peptidase 4 inhibitor (DPP4i) and, more specifically; to novel functions of a MK-0626 compound which is one of coadministrable DPP4is, for reducing the cytotoxicity of pancreatic beta cells generated by long-term administration of tacrolimus as an immunosuppressive agent, and exhibiting antidiabetic effects; and to uses thereof. COPYRIGHT KIPO 2016 (A) Confirming fibrization in tissue by dyeing Masson-Trichrome ...

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Номер записи: 44
28-05-2018 дата публикации

WATER-SWELLING RUBBER WATERSTOP

Номер: KR101861073B1
Автор: YANG, CHEL WOO
Принадлежит: YANG, CHEL WOO

The present invention relates to a water-swelling rubber waterstop. The waterstop can come in contact with moisture to be expanded in a state of being inserted into a joint between primarily applied concrete and secondarily applied concrete so as to prevent leakage into the joint. To this end, according to the present invention, the water-swelling rubber waterstop comprises: a waterstop body (11) having a rubber material expanded when absorbing moisture and having a bar shape with predetermined length; and a protruding pad (12) having the rubber material expanded when absorbing moisture and integrally protruding from an outer surface of the waterstop body (11). COPYRIGHT KIPO 2018 ...

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Номер записи: 45
27-02-2018 дата публикации

면역억제제로 유발되는 미토콘드리아 질환 및 면역 질환의 예방 또는 치료를 위한 메트포민을 포함하는 조성물

Номер: KR0101832892B1
Автор: 조미라, 양철우, 박성환, 이선영, 박민정, 전주연, 임선우, 정병하, 김은경, 김재경, 나현식, 김세영, 이은정, 서현범
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역억제제로 유발되는 미토콘드리아 질환 및 면역 질환의 예방 또는 치료를 위한 메트포민을 포함하는 조성물에 대한 것으로, 보다 상세하게는 면역억제제로 유발되는 미토콘드리아 질환 치료를 위한 메트포민을 포함하는 조성물, 메트포민과 라파마이신 표적 억제제(mTOR inhibitor)인 면역억제제를 유효성분으로 포함하는 면역 질환의 예방 또는 치료용 약학적 조성물 및 메트포민과 포유류 라파마이신 표적 억제제를 구성요소로 포함하며 이들을 동시에 또는 개별적으로 또는 정해진 순서로 투여하는 것을 특징으로 하는 면역 질환의 예방 또는 치료용 약학적 복합 제제에 관한 것이다. 본 발명의 조성물은 기존 면역억제제의 부작용으로 생기는 미토콘드리아의 기능 손상을 효과적으로 완화하고 면역억제 치료 효과는 더욱 향상되어, 면역억제가 필요한 이식거부반응, 자가면역 질환, 염증성 질환 등을 예방하거나 치료하는데 유용하게 이용될 수 있다.

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Номер записи: 46
09-02-2017 дата публикации

면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도

Номер: KR0101705446B1
Автор: 조미라, 신동윤, 박성환, 양철우, 최종영, 박민정, 손혜진, 이성희, 이선영, 김은경, 김재경, 이승훈, 박성혁
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역질환을 효과적으로 예방 및 치료할 수 있는 신규 화합물 및 이의 용도에 관한 것이다. 본 발명의 신규 화합물은 염증성 사이토카인의 생성을 억제시키며, 면역조절 기능을 갖는 조절 T 세포의 활성을 증대시킬 뿐만 아니라, 자가 항체 생산을 억제하여 과도한 면역반응을 제어할 수 있으며 파골세포의 분화를 억제할 수 있는 효과가 있어, 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환 치료를 위한 용도로 사용될 수 있는 효과가 있다.

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Номер записи: 47
12-02-2016 дата публикации

USES FOR IMPROVING IMMUNE RESPONSE BY CYCLOSPORINE OF GINSENOSIDE

Номер: KR1020160014888A
Автор: YANG, CHUL WOO, LIM, SUN WOO, HEO, SEONG BEOM
Принадлежит:

The present invention relates to novel uses for improving immune response inhibited by cyclosporine of ginsenoside and, more specifically, to novel functions of ginsenoside for inducing effective immune response, which inhibits Th17 cells inhibited by cyclosporine and increases Treg cells for inducing immunological tolerance, and to uses thereof. The composition for treating and preventing immune-related diseases improves immunosuppressive functions by cyclosporine, and comprises: a ginseng or red ginseng extract; or a ginsenoside compound separated therefrom, or derivatives thereof as an active ingredient. COPYRIGHT KIPO 2016 (AA) Proliferation of T cell (Mixed lymphocyte reaction) ...

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Номер записи: 48
21-01-2016 дата публикации

Composition for preventing or treating immune disease comprising SR11302

Номер: KR0101587687B1
Автор: 양철우, 조미라, 이선영, 문영미, 허양미, 손혜진, 유준걸, 이성희, 박민정
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 SR11302 화합물을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물에 관한 것으로서, 보다 구체적으로 본 발명은 SR11302 화합물 또는 그의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 화합물은 염증성 사이토카인을 생성 및 분비하는 세포 독성 Th17 세포의 분화를 억제하는 효과가 우수하고, 비정상적으로 활성화된 면역세포의 기능을 억제하고 염증 반응을 제어하는 특성을 갖는 면역조절 T 세포(Treg)의 활성을 증진시키는 효과가 우수하므로 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 약학적 조성물 또는 면역 억제제로 유용하게 사용할 수 있다.

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Номер записи: 49
18-04-2016 дата публикации

Novel compounds having treatment of immune diseases and use therof

Номер: KR0101613371B1
Автор: 조미라, 신동윤, 박성환, 양철우, 최종영, 박민정, 손혜진, 이성희, 이선영
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역질환을 효과적으로 예방 및 치료할 수 있는 신규 화합물 및 이의 용도에 관한 것이다. 본 발명의 신규 화합물은 염증성 사이토카인의 생성을 억제시키며, 면역조절 기능을 갖는 조절 T 세포의 활성을 증대시킬 뿐만 아니라, 자가 항체 생산을 억제하여 과도한 면역반응을 제어할 수 있으며 파골세포의 분화를 억제할 수 있는 효과가 있어, 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환 치료를 위한 용도로 사용될 수 있는 효과가 있다.

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Номер записи: 50
19-10-2016 дата публикации

IMMUNOREGULATION COMPOSITION USING COMPOSITE AGENT OF COENZYME Q10 AND OMEGA 3

Номер: KR1020160121168A
Автор: CHO, MI LA, PARK, SUNG HWAN, YANG, CHUL WOO, KWOK, SEUNG KI, JHUN, JOO YEON, LEE, SEON YEONG, KIM, JAE KYUNG, KIM, EUN KYUNG, JEONG, JEONG HEE, KIM, SE YOUNG, NA, HYUN SIK, SEO, HYEON BEOM, PARK, MIN JUNG, PARK, JIN SIL
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune disease, containing coenzyme Q10, omega 3, and zinc zinc as active ingredients. According to the present invention, the pharmaceutical composition for preventing or treating immune disease as a composite agent containing coenzyme Q10, omega 3, and zinc as the active ingredients can effectively suppresses production of inflammatory cytokines, and promotes differentiation induction and activation of immunoregulatory T cells, thereby being useful for producing treatment agents for immune diseases and functional health foods for preventing or ameliorating immune disease. COPYRIGHT KIPO 2016 ...

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Номер записи: 51
06-07-2016 дата публикации

Mesenchymal stem cells overexpressing sRAGE and cell therapeutic agent for preventing or treating immune disease

Номер: KR0101636139B1
Автор: 조미라, 양철우, 박민정, 이성희, 이정아, 문영미, 서현범, 김은경, 이선영
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역조절능이 우수하고 안정한 sRAGE 과발현 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물에 관한 것으로, 보다 구체적으로, 본 발명은 sRAGE(soluble receptor for advanced glycation endproducts) 유전자가 도입되어 이를 과발현하는 형질전환된 간엽줄기세포 및 상기 간엽줄기세포를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물에 관한 것이다. 본 발명에 따라 제조된 간엽줄기세포는 면역조절능을 갖는 유전자 및 세포이동 관련 유전자들의 발현을 증가시키는 효과가 있고, 염증성 사이토카인 및 염증세포의 증식은 억제시키면서 동시에 면역조절 T 세포의 증식은 촉진시키는 활성을 가지고 있어 면역질환 치료를 위한 세포치료제로 유용하게 사용할 수 있는 효과가 있다.

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Номер записи: 52
23-06-2016 дата публикации

COMPOSITION FOR ALLEVIATING NEPHROTOXICITY CAUSED BY IMMUNOSUPPRESSIVE DRUG, CONTAINING METFORMIN, AND COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES, CONTAINING SAME

Номер: WO2016099214A1
Автор: CHO, Mi La, YANG, Chul Woo, CHOI, Jong Young, PARK, Sung Hwan, PARK, Min Jung, LEE, Seon Yeong, JHUN, Joo Yeon, LEE, Eun Jung, KIM, Jae Kyung, KIM, Eun Kyung, LIM, Sun Woo
Принадлежит:

The present invention relates to a composition for alleviating nephrotoxicity caused by an immunosuppressive drug, containing metformin, and a composition for preventing or treating immune diseases, containing the same and, more specifically, to a composition for reducing nephrotoxicity caused by an immunosuppressive drug, containing metformin as an active ingredient, a pharmaceutical composition for preventing or treating immune diseases, containing metformin and a calcineurin inhibitor as active ingredients, and a pharmaceutically combined preparation for preventing or treating immune diseases, containing metformin and a calcineurin inhibitor as constituent elements, wherein the metformin and the calcineurin inhibitor are administered simultaneously, individually or in a predetermined order. The composition of the present invention can be useful for improving a treatment effect on diseases requiring immunosuppression by effectively alleviating the deterioration of a renal function caused ...

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Номер записи: 53
21-09-2018 дата публикации

COMPOSITION FOR PREVENTING OR TREATING ARTHRITIS, FIBROSIS, COLITIS, OR TRANSPLANT REJECTION COMPRISING LACTOBACILLUS ACIDOPHILUS

Номер: KR1020180104544A
Автор: CHO MI LA, PARK SUNG HWAN, YANG CHUL WOO, CHOI JEONG WON, PARK JIN SIL, SEON YEONG LEE, JHUN JOO YEON, JUNG KYUNG AH, HAN WOO AH, CHOI JONG YOUNG, LEE AH LUM
Принадлежит:

The present invention relates to a composition for preventing or treating one or more selected from the group consisting of arthritis, fibrosis, colitis, and transplant rejection, which comprises Lactobacillus acidophilus as an effective component, and to various applications thereof. The composition of the present invention, when using Lactobacillus acidophilus alone, effectively suppresses inflammatory cytokines, has Th17/Treg regulatory ability, and suppresses oxidative stress and apoptosis, and thus shows excellent treatment effects for arthritis, fibrosis, colitis, or transplant rejection. In addition, the composition, when using a calcineurin inhibitor FK506, in combination with the Lactobacillus acidophilus, regulates T cells to suppress immune rejections in alloresponse, and thus is effective in the treatment of transplant rejection and graft-versus-host disease (GVHD), and further may be beneficially used in the industries relating thereto. COPYRIGHT KIPO 2018 ...

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Номер записи: 54
24-05-2017 дата публикации

면역질환 치료 효능을 갖는 Ｇｒｉｍ１９이 과발현된 중간엽줄기세포 및 이의 용도

Номер: KR0101739659B1
Автор: 조미라, 김석중, 양철우, 박성환, 박민정, 이선영, 이은정
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 면역질환 치료를 위한 세포치료제 조성물에 관한 것으로, 보다 구체적으로 Grim19 유전자를 함유한 재조합 벡터로 형질전환된 중간엽줄기세포를 유효성분으로 포함하는, 면역질환의 예방 또는 치료용 세포치료제 조성물에 관한 것이다. 본 발명에 따른 Grim19 유전자를 함유한 재조합 벡터로 형질전환된 중간엽줄기세포는 염증성 사이토카인 및 염증 유발인자의 발현과 생성을 효과적으로 억제할 수 있고, 병인조건 하에서 미분화 T 세포와 공조 배양할 경우, T 세포의 세포 독성 Th17 및 Th1 세포로의 분화를 억제하는 효과가 있으며, 비정상적으로 활성화된 면역세포의 기능을 억제하고 염증 반응을 제어하는 특성을 갖는 면역조절 T 세포(Treg)의 분화 및 활성을 증진시키는 효과가 우수한 특징이 있다. 나아가 병변부위로 신속하고 정확하게 이동할 수 있는 능력이 있어 Grim19 유전자를 함유한 재조합 벡터로 형질전환된 본 발명의 중간엽줄기세포는 각종 면역반응의 조절 이상으로 유발되는 자가면역질환, 염증성질환 및 이식거부질환과 같은 면역질환을 예방 또는 치료할 수 있는 세포치료제 조성물로 사용할 수 있는 효과가 있다.

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Номер записи: 55
19-09-2018 дата публикации

COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES COMPRISING MIXTURE OF LACTIC ACID BACTERIA

Номер: KR1020180103772A
Автор: CHO MI LA, PARK SUNG HWAN, YANG CHUL WOO, SEON YEONG LEE, JHUN JOO YEON, SEO HYEON BEOM, KWUAN JI YE, RYU JUN GEOL, CHO KEUN HYUNG, CHOI JEONG WON, RYU JAE YOON, KIM EUN KYUNG, JUNG KYUNG AH, LEE SEUNG HOON, LEE AH LUM, NA HYUN SIK
Принадлежит:

The present invention relates to a composition for preventing and treating immune diseases comprising a mixture of lactic acid bacteria and various applications thereof. The composition of the present invention is a mixture of probiotics or prebiotics in the most effective ratio, thereby having an effect of inhibiting an expression of inflammatory cytokines and an expression of cartilage destruction factors when compared with conventional anti-inflammatory drugs in vitro or in vivo. In addition, the cartilage protective factor and anti-inflammatory cytokine expression are enhanced, and cartilage protective effect is confirmed to be excellent in an animal model for immunological diseases, so the composition can be usefully used in related pharmaceutical and health functional food industries. COPYRIGHT KIPO 2018 ...

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Номер записи: 56
16-04-2015 дата публикации

COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE, USING COMPLEX OF METFORMIN AND STATIN

Номер: WO2015053589A1
Автор: CHO, Mi-La, PARK, Sung-Hwan, PARK, Min-Jung, JHUN, Joo-Yeon, LEE, Sung-Hee, BYUN, Jae-Kyeong, JEONG, Jeong-Hee, LEE, Jeong-Ah, KWOK, Seung-Ki, LEE, Jennifer, JU, Ji-Hyeon, YANG, Chul-Woo, NA, Hyun-Sik, LEE, Eun-Jung, LEE, Seon-Yeong, YANG, Eun-Ji, SON, Hye-Jin
Принадлежит:

The present invention relates to a composition for preventing or treating autoimmune diseases, using a complex containing metformin, statin and, optionally, Coenzyme Q10. According to the present invention, a pharmaceutical composition for preventing or treating autoimmune diseases, which is the complex containing metformin, statin and, optionally, Coenzyme Q10, as active ingredients, can effectively inhibit the generation of inflammatory cytokines, can inhibit the generation of antibody-producing B cells or can reduce the activity thereof, has effects of inhibiting osteoclast differentiation and inhibiting joint destruction, and exhibits a remarkable effect of inhibiting the generation of foam cells, which generate artherosclerotic plaque progenitor cells, and thus can be useful as an agent for treating immunological diseases including autoimmune diseases.

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Номер записи: 57
19-02-2015 дата публикации

MTOR/STAT3 SIGNAL INHIBITOR-TREATED MESENCHYMAL STEM CELL HAVING IMMUNOMODULATORY ACTIVITY, AND CELL THERAPY COMPOSITION COMPRISING SAME, FOR PREVENTING OR TREATING IMMUNE DISORDERS

Номер: WO2015023147A1
Автор: YANG, Chul Woo, CHO, Mi-La, PARK, Sung-Hwan, MOON, Su-Jin, KIM, Eun Kyung, CHUNG, Byung Ha, KIM, Kyoung-Woon, LEE, Seon-Yeong, LEE, Sung-Hee, YANG, Eun Ji, JEONG, Jeong-hee, PARK, Min Jung, KIM, Seok-Jung, LEE, Eun-Jung
Принадлежит:

The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having mmunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-β and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII. If this cell is ...

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Номер записи: 58
27-09-2018 дата публикации

WATER-EXPANDABLE RUBBER RING TO CONNECT HUME PIPE AND MANUFACTURING METHOD THEREOF

Номер: KR101901816B1
Автор: YANG, CHEL WOO
Принадлежит: YANG, CHEL WOO

The present invention relates to a water-expandable rubber ring to connect a Hume pipe, which is extended in a longitudinal direction and is installed in a connection part of the home pipe to be used for socket joint, and a manufacturing method thereof. According to one embodiment of the present invention, the water-expandable rubber ring to connect a Hume pipe is manufactured by forming a rubber ring made through a unique mixing ratio and process, and comprises: an inclined surface inclined at a predetermined angle from a lower surface; a slit groove disposed on the upper surface and extended in a longitudinal direction; a protecting step disposed between the slit grooves and extended in the longitudinal direction of the slit groove; a lower slit disposed on the lower surface and formed to repeat a wave pattern arrangement; and a through-hole having an inner part penetrated in parallel to the longitudinal direction of the slit groove. Accordingly, water tightness in Hume pipe joint is ...

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Номер записи: 59
18-08-2015 дата публикации

SEMICONDUCTOR APPARATUS

Номер: KR1020150093474A
Автор: PARK, YI SEUL, YANG, CHUL WOO
Принадлежит:

A semiconductor apparatus includes: a memory block including memory cells for storing data and flag cells for storing erasing state information; an operation circuit formed to perform a program operation, an erasing operation, and a lead operation of the memory cells or the flag cell; and a data change circuit formed to encode data. The data change circuit codes the data read from the memory cells according to the erasing state information. COPYRIGHT KIPO 2015 (250) Read/write circuit (260) IO circuit (271B) Encryption circuit (275) Selection circuit ...

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Номер записи: 60
19-02-2018 дата публикации

KIT FOR MONITORING ORGAN TRANSPLANT REJECTION OR POST-TRANSPLANT IMMUNE STATUS

Номер: KR101829997B1
Автор: YANG, CHUL WOO, CHUNG, BYUNG HA, KIM, KYOUNG WOON, DOH, KYOUNG CHAN, KIM, BO MI
Принадлежит: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

The present invention relates to a new diagnostic kit capable of deciding a time of decreasing a dose of immunosuppressant and whether to administer the immunosuppressant or not by monitoring an organ transplant rejection or post-transplant immune status of a patient. The present invention relates to an organ transplant rejection test kit or a post-transplant immune status monitoring kit comprising a substance for measuring CCR7 + CD8 + T cells and CD57 + CD28nullCD8 + T cells. When the kit provided in the present invention is used, the post-transplant immune status in an individual can be easily and accurately determined, thereby having effects of reducing excessive use of immunosuppressant prescribed after the transplantation and conveniently managing the immune status of each individual patient. COPYRIGHT KIPO 2018 ...

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Номер записи: 61
17-05-2017 дата публикации

COMPOSITION FOR MITIGATING NEPHROTOXIN DUE TO IMMUNOSUPPRESSANT INCLUDING METFORMIN AND COMPOSITION FOR PREVENTING OR TREATING IMMUNOLOGICAL DISEASE COMPRISING SAME

Номер: KR1020170054359A
Автор: CHO, MI LA, YANG, CHUL WOO, CHOI, JONG YOUNG, PARK, SUNG HWAN, PARK, MIN JUNG, LEE, SEON YEONG, JHUN, JOO YEON, LEE, EUN JUNG, KIM, JAE KYUNG, KIM, EUN KYUNG, LIM, SUN WOO
Принадлежит:

The present invention relates to a composition for mitigating nephrotoxin due to an immunosuppressant including metformin and a composition for preventing or treating an immunological disease comprising the same. More particularly, the present invention relates to a pharmaceutical composite formulation for preventing or treating the immunological disease, which comprises the composition for mitigating the nephrotoxin caused by the immunosuppressant including the metformin as an active ingredient, a pharmaceutical composition for preventing or treating the immunological disease including the metformin and a calcineurin inhibitor as an active ingredient, a metformin and calcineurin inhibitor, wherein the compositions and the metformin and calcineurin inhibitor are administered simultaneously, individually or in a predetermined order. The compositions of the present invention can be useful for mitigating effectively a kidney dysfunction caused by side effects of existing immunosuppressants ...

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Номер записи: 62
02-03-2017 дата публикации

COMPOSITION FOR PREVENTING OR TREATING MITOCHONDRIAL DISEASES CAUSED BY IMMUNOSUPPRESSANTS, AND IMMUNE DISEASES, CONTAINING METFORMIN

Номер: WO2017034315A1
Автор: CHO, Mi La, YANG, Chul Woo, PARK, Sung Hwan, LEE, Seon Yeong, PARK, Min Jung, JHUN, Joo Yeon, LIM, Sun Woo, CHUNG, Byung Ha, KIM, Eun Kyung, KIM, Jae Kyung, ΝΑ, Hyun-Sik, KIM, Se-Young, LEE, Eun Jung, SEO, Hyeon-Beom
Принадлежит:

The present invention relates to a composition for preventing or treating mitochondrial diseases caused by immunosuppressants, and immune diseases, containing metformin and, more specifically, to a composition for treating mitochondrial diseases caused by immunosuppressants, containing metformin; a pharmaceutical composition for preventing or treating immune diseases, containing, as active ingredients, metformin and an immunosuppressant, which is a target of rapamycin inhibitor (mTOR inhibitor); and a pharmaceutical composite formulation for preventing or treating immune diseases, containing, as ingredients, metformin and a mammalian target of rapamycin inhibitor, wherein the metformin and mammalian target of rapamycin inhibitor are administered simultaneously or separately, or administered in a predetermined sequence. The composition of the present invention effectively alleviates mitochondrial dysfunction, occurring as a side effect of conventional immunosuppressants, while having a more ...

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Номер записи: 63
10-07-2017 дата публикации

COADMINISTRATION OF RESVERATROL AND TACROLIMUS USED FOR IMPROVING AN IMMUNE REACTION

Номер: KR1020170079102A
Автор: YANG, CHUL WOO, CHO, MI LA, CHUNG, BYUNG HA, KIM, KYOUNG WOON, DOH, KYOUNG CHAN, KIM, BO MI
Принадлежит:

The present invention relates to coadministration of tacrolimus which further improves an immune reaction by resveratrol, and more specifically, to coadministration of resveratrol and tacrolimus which induces an effective immune reaction by further inhibiting Th17 cells inhibited by resveratrol and adjusting AMPK/mTOR, and to use thereof. Since the resveratrol of the present invention has an effect of improving immunosuppressive ability, in treatment and prevention of various immune diseases, and in organ transplantation, it is possible to use an improved immunosuppressive effect improved remarkably by combination (coadministration) of resveratrol and tacrolimus. COPYRIGHT KIPO 2017 ...

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Номер записи: 64