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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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18-07-2016 дата публикации

ROOF DRAIN DEVICE

Номер: KR101640573B1
Автор: KWAK, SEUNG GI, KIM, YOUNG SOO, YANG, KYOUNG TAK
Принадлежит: IMS CO., LTD.

The present invention relates to a roof drain device. The roof drain device is to prevent a contaminant from being discharged to a river by rainwater when a roof floor is contaminated due to a leakage of a pipe and damage to the passing pipe or a facility of a building roof. The roof drain device includes: a cylinder unit operated by an air pressure or a fluid pressure; a valve unit connected to an end of a piston rod of the cylinder unit; a flange unit comprising a plate unit in which a connection unit inserted into a drainage hole is integrally formed; and a housing having a connection plate unit formed on one side and connected to the plate unit, and a cylinder unit fixed to the other side in order for the end of the piston rod to be installed on the inner side, wherein the housing also has multiple through holes on the side and the multiple through holes are formed at fixed intervals. COPYRIGHT KIPO 2016 ...

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Номер записи: 1
12-03-2015 дата публикации

COMPOSITION FOR TREATING OR PREVENTING BONE DISEASES, COMPRISING HALOFUGINONE AS ACTIVE INGREDIENT

Номер: WO2015034330A1
Автор: PARK, Sung-Hwan, CHO, Mi-La, PARK, Mi-Kyung, KWOK, Seung-Ki, LEE, Jennifer, PARK, Jin-Sil, KIM, Sung-Min, LIM, Mi-Ae, BAEK, Seung-Ye, LEE, Dong-Gun, PARK, Eun-Mi
Принадлежит:

The present invention relates to a composition for treating or preventing bone diseases, comprising halofuginone as an active ingredient and, more specifically, to a composition for treating or preventing bone diseases, comprising, as an active ingredient, halofuginone having an osteoclast differentiation inhibitory efficacy and an osteoblast differentiation stimulatory activity. The composition for treating or preventing bone diseases, comprising halofuginone as an active ingredient, according to the present invention, reduces the expression of Th17 cells and increases the expression of Treg cells, thereby representing an effect of inhibiting osteoclast differentiation and being capable of also effectively inhibiting bone resorption by osteoclast. Furthermore, the composition of the present invention will be able to be usefully utilized as a use for treatment or prevention of bone diseases by being able to promote the differentiation and activity of osteoblast.

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Номер записи: 2
20-11-2017 дата публикации

쇼그렌 증후군 진단 마커로서 ＳＩＧＬＥＣ５의 용도

Номер: KR0101789910B1
Автор: 곽승기, 박성환, 이주하, 이재선, 고정희
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명에 따른 쇼그렌 증후군 마커 단백질인 SIGLEC5(sialic acid binding Ig-like lectin 5)는 정상 대조군 타액에 비해 쇼그렌 증후군 환자의 타액에서 특이적으로 발현양이 증가되어 있어, 환자의 체내 SIGLEC5의 mRNA 또는 SIGLEC5 단백질의 수준을 측정하는 것이 조기에 쇼그렌 증후군을 객관적이고 정확하게 진단할 수 있게 하여 효과적으로 쇼그렌 증후군의 예방 또는 치료할 수 있는 효과가 있다. 따라서 상기 본 발명에서 발굴한 SIGLEC5는 쇼그렌 증후군의 진단을 위한 타겟으로 유용하게 사용될 수 있다.

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Номер записи: 3
23-04-2020 дата публикации

HUMANIZED AUTOIMMUNE DISEASE ANIMAL MODEL AND USE THEREOF

Номер: WO2020080791A1
Автор: PARK, Sung-Hwan, CHO, Mi-La, JU, Ji-Hyeon, KWOK, Seung-Ki, PAKR, Min-Jung, KIM, Se-Young, BAEK, Jin-Ah, KIM, Ju-Ryun, KIM, Ye-Na, CHOI, Jeong-Won, JUNG, Kyung-Ah
Принадлежит:

The present invention relates to use of a mouse humanized by a cell of an autoimmune disease patient and/or a tissue derived therefrom. A humanized autoimmune mouse according to the present invention reflects the immune state of an autoimmune disease patient well, and a human cell is well-engrafted in the blood and various tissues of the mouse, and thus, the humanized autoimmune mouse can be used as a preclinical model for monitoring the immune state of the patient and can also be used in the screening of an autoimmune disease treatment material or a skin graft immunosuppressant.

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Номер записи: 4
28-04-2022 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF RHEUMATOID ARTHRITIS, COMPRISING, AS ACTIVE INGREDIENT, STEM CELLS HAVING EXPRESSION OF SPECIFIC GENES INCREASED OR DECREASED THEREIN

Номер: WO2022086276A1
Автор: KIM, Sung Won, KWOK, Seung Ki, LEE, Jaeseon, JANG, Se Gwang, LIM, Jung Yeon, PARK, Sun Hwa, CHUN, Jung Ho
Принадлежит:

The present invention relates to a pharmaceutical composition for prevention or treatment of rheumatoid arthritis, the composition comprising, as an active ingredient, human nasal inferior turbinate-derived stem cells in which the expression of specific genes is increased or decreased. The human nasal inferior turbinate-derived stem cells exhibiting a therapeutic effect on arthritis were identified to specifically have an increased expression level of HAS2, CXCL1, or KRTAP1-5 gene or a decreased expression level of GSTT2B or C4B gene. Thus, by taking advantage of this feature, only stem cells that have a therapeutic effect on arthritis can be selected for use in treating rheumatoid arthritis, with the expectation of enhancing the therapeutic effect. Furthermore, it is expected that a method for selecting stem cells useful as a therapeutic agent for rheumatoid arthritis can be provided.

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Номер записи: 5
19-02-2015 дата публикации

INFLAMMATION-CONTROLLING COMPOSITE AND STABILIZED MESENCHYMAL STEM CELLS HAVING OPTIMIZED IMMUNITY CONTROL FUNCTION BY BLOCKING STAT3 SIGNAL MOLECULE

Номер: WO2015023165A1
Автор: CHO, Mi-La, YANG, Chul-Woo, PARK, Min-Jung, LEE, Sung-Hee, LEE, Jeong-Ah, MUN, Yeong-Mi, SEO, Hyeon-Beom, KIM, Eun-Kyung, LEE, Seon-Yeong, PARK, Sung-Hwan, MOON, Su-Jin, KWOK, Seung-Ki, JEONG, Jeong-Hee, YANG, Eun-Ji, KIM, Seok-Jung, LEE, Eun-Jung
Принадлежит:

The present invention relates to stable sRAGE-overexpressed mesenchymal stem cells having an excellent immunity control function and a cell-treatment agent composition containing same for preventing or treating immune disease. Also, the present invention relates to: a method for preparing mesenchymal stem cells capable of mass-producing human transforming growth factor-beta (TGF-β) and having the immunity control function, comprising a step of treating, with metformin, a mesenchymal stem cell having immunological characteristics of positive CD105, DC29, and CD44 and negative CD34, CD45, and HLA-DR, and cultivating same for 14 to 21 days at a temperature of 28 to 42℃; mesenchymal stem cells prepared by the method; and the cell-treatment agent composition containing the mesenchymal stem cells for treating or preventing immune disease.

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Номер записи: 6
23-09-2016 дата публикации

메트포민이 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물

Номер: KR0101659158B1
Автор: 조미라, 양철우, 박성환, 문수진, 곽승기, 박민정, 이선영, 이성희, 정정희, 양은지, 김은경, 김석중, 이은정
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 CD105, CD29 및 CD44는 양성이며 CD34, CD45 및 HLA-DR는 음성의 면역학적 특징을 갖는 간엽줄기세포에 메트포민을 처리하여, 28~42℃의 온도에서 14 ~ 21일 동안 배양하는 단계를 포함하는, 인간형질전환 성장인자-베타(TGF-β)를 대량생산하고 면역조절능을 갖는 간엽줄기세포의 제조방법 및 상기 방법으로 제조된 간엽줄기세포, 상기 간엽줄기세포를 함유하는 면역질환 치료 또는 예방용 세포치료제 조성물에 관한 것이다. 본 발명에 따른 메트포민이 처리된 면역조절능을 갖는 간엽줄기세포는 면역조절능을 갖는 인자인 IDO, TGF-beta 또는 IL-10의 발현이 증가되어 있고, 자가포식작용 및 미토콘드리아 활성을 증가되어 있어 면역질환 치료를 위한 세포치료제로 유용하게 사용할 수 있는 효과가 있다.

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Номер записи: 7
06-09-2016 дата публикации

헬로퓨지농을 유효성분으로 포함하는 골질환 치료 또는 예방용 조성물

Номер: KR0101654980B1
Автор: 박성환, 조미라, 박미경, 곽승기, 이주하, 박진실, 김성민, 임미애, 백승예, 이동건, 박은미
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 헬로퓨지농을 유효성분으로 포함하는 골질환 치료 또는 예방용 조성물에 관한 것으로, 더 상세하게는 파골세포 분화 억제 효능 및 조골세포 분화 촉진 활성을 갖는 헬로퓨지농을 유효성분으로 포함하는 골질환 치료 또는 예방용 조성물에 관한 것이다. 본 발명에 의한 헬로퓨지농을 유효성분으로 포함하는 골질환의 치료 또는 예방용 조성물은 Th17 세포의 발현을 감소시키고 Treg 세포의 발현을 증가시켜 파골세포 분화를 억제하는 효과를 나타내며 파골세포에 의한 골 흡수도 효과적으로 억제할 수 있고 나아가 조골세포의 분화 및 활성을 촉진할 수 있어 골질환의 치료 또는 예방을 위한 용도로 유용하게 활용할 수 있을 것이다.

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Номер записи: 8
11-05-2017 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SPONDYLITIS ANKYLOPOIETICA CONTAINING SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) INHIBITOR AS ACTIVE INGREDIENT

Номер: KR1020170050566A
Автор: CHO, MI LA, PARK, SUNG HWAN, KWOK, SEUNG KI, MIN, HONG KI, LEE, SEON YEONG, KIM, JAE KYUNG, LEE, SEUNG HUN, KIM, EUN KYUNG, KWON, JEONG EUN, SEO, HYEON BEOM
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating spondylitis ankylopoietica containing signal transducer and activator of transcription 3 (STAT3) inhibitor as an active ingredient. More specifically, the composition containing rebamipide which is STAT3 inhibitor or protein inhibitor of activated STAT3 (PIAS3) can effectively treat and alleviate symptoms of spondylitis ankylopoietica, reduces expression of tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) which are inflammatory cytokines, and effectively recovers tissue damage on small intestine and large intestine. Accordingly, the STAT3 inhibitor can be used as a novel treatment agent for spondylitis ankylopoietica ultimately. COPYRIGHT KIPO 2017 ...

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Номер записи: 9
02-06-2016 дата публикации

Composition for preventing or treating autoimmune disease comprising metformin and statin

Номер: KR0101627045B1
Автор: 조미라, 박성환, 박민정, 전주연, 이성희, 변재경, 정정희, 이정아, 곽승기, 이주하, 주지현, 양철우, 나현식, 이은정
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 메트포민 및 스타틴의 복합제를 이용한 자가면역질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 메트포민 및 스타틴을 유효성분으로 포함하는 복합제인 자가면역질환의 예방 또는 치료용 약학적 조성물은 염증성 사이토카인의 생성을 효과적으로 억제시킬 수 있고, 항체 생산 B 세포의 생성을 저해 또는 활성을 감소시킬 수 있으며, 파골세포의 분화를 억제하고 관절파괴를 억제하는 효과를 가지며 동맥경화반(Artherosclerotic plaque) 전구세포를 형성하는 거품세포(Foam cell)의 생성 억제 효과가 뛰어나 메트포민 및 스타틴을 유효성분으로 하는 복합제는 자가면역질환의 치료제로서 매우 유용하게 활용될 수 있다.

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Номер записи: 10
21-03-2019 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RHEUMATOID ARTHRITIS INCLUDING INFERIOR NASAL CONCHA-DERIVED MESENCHYMAL STEM CELL AS ACTIVE INGREDIENT

Номер: WO2019022386A3
Автор: KIM, Sung Won, KWOK, Seung Ki, LEE, Jaeseon, PARK, Sun hwa
Принадлежит:

The present invention relates to: a pharmaceutical composition for preventing or treating rheumatoid arthritis including an inferior nasal concha-derived mesenchymal stem cell as an active ingredient; and a stem cell therapeutic agent for treating rheumatoid arthritis. An inferior nasal concha-derived mesenchymal stem cell according to the present invention has the effects of reducing the proliferation of interleukin-17A (IL-17A), tumor necrosis factor-alpha (TNF-α), inflammation-inducing factor immunoglobulin G2a (IgG2a), and/or lymph node T-cells, increasing interleukin-10 (IL-10) and/or regulatory T-cells (Treg, CD4+CD25+foxp3+ cell) that contribute to immunotolerance in spleen cells, and inhibiting the proliferation of human T-cells. The inferior nasal concha-derived mesenchymal stem cell has a safer acquisition process than existing mesenchymal stem cells and can be acquired in sufficient amounts within a desired period of time, thus allowing mesenchymal stem cells to be acquired at ...

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Номер записи: 11
10-10-2016 дата публикации

COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE, CONTAINING SSU72 AS ACTIVE INGREDIENT

Номер: KR1020160117352A
Автор: CHO, MI LA, PARK, SUNG HWAN, LEE, CHANG WOO, KWOK, SEUNG KI, CHOI, JONG YOUNG, LEE, SEUNG HUN, SEO, HYEON BEOM, MOON, YOUNG MEE, PARK, JIN SIL, PARK, MIN JUNG, LEE, JIN KWAN
Принадлежит:

The present invention relates to a composition for preventing or treating autoimmune disease, containing Ssu72 as an active ingredient. According to the present invention, Ssu72 effectively inhibits activities of STAT3, and thus suppresses expression of inflammatory cytokines when Ssu72 is over-expressed while promoting expression of IL-4 and IL-10 which are factors associated with immunoregulatory T cells, thereby effectively preventing and treating immune disease and, more favorably, STAT3-mediated disease. COPYRIGHT KIPO 2016 ...

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Номер записи: 12
04-12-2017 дата публикации

세포 현탁액 및 아바타셉트를 포함하는 나노좀 형태의 면역치료제

Номер: KR0101803977B1
Автор: 박성환, 조미라, 곽승기, 박미경, 이동건, 박은미, 고용송, 김윤근, 장수철
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 세포 현탁액 및 아바타셉트(abatacept)를 포함하는 나노좀 형태의 면역치료제에 관한 것이다. 본 발명의 세포 현탁액 및 아바타셉트(abatacept)를 포함하는 나노좀 형태의 면역치료제는 표적부위로의 아바타셉트의 전달율이 높기 때문에, 아바타셉트 자체를 직접적으로 사용한 경우와 비교하여 염증성 사이토카인인 TNF-α의 생성 및 IL-17의 생성을 더욱 효과적으로 억제시킬 수 있어 면역질환 예방 또는 치료에서 유용하게 사용될 수 있다.

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Номер записи: 13
31-01-2019 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RHEUMATOID ARTHRITIS INCLUDING INFERIOR NASAL CONCHA-DERIVED MESENCHYMAL STEM CELL AS ACTIVE INGREDIENT

Номер: WO2019022386A2
Автор: KIM, Sung Won, KWOK, Seung Ki, LEE, Jaeseon, PARK, Sun hwa
Принадлежит:

The present invention relates to: a pharmaceutical composition for preventing or treating rheumatoid arthritis including an inferior nasal concha-derived mesenchymal stem cell as an active ingredient; and a stem cell therapeutic agent for treating rheumatoid arthritis. An inferior nasal concha-derived mesenchymal stem cell according to the present invention has the effects of reducing the proliferation of interleukin-17A (IL-17A), tumor necrosis factor-alpha (TNF-α), inflammation-inducing factor immunoglobulin G2a (IgG2a), and/or lymph node T-cells, increasing interleukin-10 (IL-10) and/or regulatory T-cells (Treg, CD4+CD25+foxp3+ cell) that contribute to immunotolerance in spleen cells, and inhibiting the proliferation of human T-cells. The inferior nasal concha-derived mesenchymal stem cell has a safer acquisition process than existing mesenchymal stem cells and can be acquired in sufficient amounts within a desired period of time, thus allowing mesenchymal stem cells to be acquired at ...

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Номер записи: 14
25-06-2020 дата публикации

NOVEL CYTOKINES AND USE THEREOF

Номер: WO2020130711A1
Автор: CHO, Mi-La, YANG, Chul-Woo, PARK, Sung-Hwan, LEE, Seon-Yeong, MOON, Young-Mee, KWOK, Seung-Ki, SEO, Hyeon-Beom, RYU, Jun-Geol, KIM, Eun-Kyung
Принадлежит:

The present invention relates to a novel composite that is formed by linking subunit p40 and subunit EBI3 via a linker and has excellent anti-inflammatory effects and immunomodulatory effects.

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Номер записи: 15
01-12-2017 дата публикации

Ssu72를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 조성물

Номер: KR0101803636B1
Автор: 조미라, 박성환, 이창우, 곽승기, 최종영, 이승훈, 서현범, 문영미, 박진실, 박민정, 이진관
Принадлежит: 가톨릭대학교 산학협력단, 성균관대학교산학협력단

... 본 발명은 Ssu72를 유효성분으로 함유하는 자가면역질환의 예방 또는 치료용 조성물에 관한 것으로, 본 발명에 따른 Ssu72는 STAT3의 활성을 효과적으로 억제할 수 있는 효과가 있어, Ssu72를 과발현 시킨 경우 염증성 사이토카인의 발현을 억제할 수 있고 동시에 면역조절 T세포와 관련된 인자인 IL-4 및 IL-10의 발현은 촉진시키는 작용을 통해 궁극적으로 면역질환, 바람직하게는 STAT3 매개 질환을 효과적으로 예방 및 치료할 수 있다.

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Номер записи: 16
11-04-2017 дата публикации

COMPOSITION FOR TREATING OR PREVENTING BONE DISEASES COMPRISING FRAXINELLONE

Номер: KR101725714B1
Автор: KWOK, SEUNG KI, PARK, SUNG HWAN, CHO, MI LA, LEE, JAE SEON, JUNG, SEUNG MIN
Принадлежит: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

The present invention relates to a composition which is used for treating or preventing bone diseases and comprises a fraxinellone compound or a pharmaceutically acceptable salt thereof as an active ingredient. According to the present invention, the composition used for treating or preventing bone diseases and comprising a fraxinellone compound or a pharmaceutically acceptable salt thereof as an active ingredient can reduce differentiation of Th17 cells and activities of transcription factors involved therein; suppress differentiation of plasma cell and antibody formation thereof; and has an excellent effect of suppressing differentiation of osteoclasts, and thus may be beneficially used to treat bone diseases. COPYRIGHT KIPO 2017 ...

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Номер записи: 17
06-10-2016 дата публикации

COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE, CONTAINING SSU72 AS ACTIVE INGREDIENT

Номер: WO2016159695A1
Автор: CHO, Mi-La, PARK, Sung-Hwan, LEE, Chang-Woo, KWOK, Seung-Ki, CHOI, Jong-Young, LEE, Seung-Hun, SEO, Hyeon-Beom, MOON, Young-Mee, PARK, Jin-Sil, PARK, Min-Jung, LEE, Jin-Kwan
Принадлежит:

The present invention relates to a composition for preventing or treating an autoimmune disease, containing Ssu72 as an active ingredient. According to the present invention, Ssu72 has an effect of effectively inhibiting STAT3 activity, thereby effectively preventing and treating, ultimately, an immune disease, and preferably, STAT3-mediated diseases through an action capable of inhibiting the expression of inflammatory cytokines when Ssu72 is overexpressed and simultaneously promoting the expression of IL-4 and IL-10, which are factors associated with regulatory T cells.

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Номер записи: 18
06-10-2016 дата публикации

COMPOSITION FOR PREVENTING OR TREATING SJOGREN′S SYNDROME COMPRISING PAX3 AS ACTIVE INGREDIENT

Номер: KR1020160115176A
Автор: PARK, SUNG HWAN, CHO, MI LA, KWOK, SEUNG KI, KIM, SUNG MIN, PARK, JIN SIL, MOON, YOUNG MEE, SEO, HYEON BEOM, KIM, NA RAE
Принадлежит:

The present invention relates to applicability of PAX3 as a novel agent for treating Sjogren′s syndrome effectively. According to the present invention, it is shown that over-expression of PAX3 in an animal model, in which Sjogren′s syndrome occurs, alleviates and improves the conditions of Sjogren′s syndrome and inhibits production of inflammatory cytokines. In addition, after analyzing variations in expression of PAX3 upon the onset of Sjogren′s syndrome in an in vitro test using a sample of a patient suffering from Sjogren′s syndrome, it is demonstrated that expression of PAX3 is reduced when the environment of Sjogren′s syndrome is formed. Therefore, according to the present invention, it can be seen that PAX3 can be a novel target of an agent for treating Sjogren′s syndrome. It can be also seen that PAX3 and an accelerator for expression and activity of PAX3 are effective for preventing and treating Sjogren′s syndrome. COPYRIGHT KIPO 2016 (AA) Salivary gland (BB) Parotid gland ...

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Номер записи: 19
19-10-2016 дата публикации

IMMUNOREGULATION COMPOSITION USING COMPOSITE AGENT OF COENZYME Q10 AND OMEGA 3

Номер: KR1020160121168A
Автор: CHO, MI LA, PARK, SUNG HWAN, YANG, CHUL WOO, KWOK, SEUNG KI, JHUN, JOO YEON, LEE, SEON YEONG, KIM, JAE KYUNG, KIM, EUN KYUNG, JEONG, JEONG HEE, KIM, SE YOUNG, NA, HYUN SIK, SEO, HYEON BEOM, PARK, MIN JUNG, PARK, JIN SIL
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune disease, containing coenzyme Q10, omega 3, and zinc zinc as active ingredients. According to the present invention, the pharmaceutical composition for preventing or treating immune disease as a composite agent containing coenzyme Q10, omega 3, and zinc as the active ingredients can effectively suppresses production of inflammatory cytokines, and promotes differentiation induction and activation of immunoregulatory T cells, thereby being useful for producing treatment agents for immune diseases and functional health foods for preventing or ameliorating immune disease. COPYRIGHT KIPO 2016 ...

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Номер записи: 20
06-10-2016 дата публикации

METHOD FOR PRODUCING AVATARA WHICH IS RHEUMATOID ARTHRITIS ANIMAL MODEL BY TRANSPLANTING SYNOVIAL TISSUE

Номер: KR1020160115522A
Автор: PARK, SUNG HWAN, CHO, MI LA, KWEON, MI NA, KWOK, SEUNG KI, LEE, YONG SOO, KIM, SUNG MIN, PARK, JIN SIL, KIM, EUN KYUNG, KIM, NA RAE, MIN, HONG KI
Принадлежит:

The present invention relates to a method for producing an avatara which is a rheumatoid arthritis animal model. More specifically, synovial tissue separated from a rheumatoid arthritis patient is transplanted, and peripheral blood monocytes and synovial cells are additionally fed. When an animal model is produced according to the present invention, an animal model for personally customized treatment can be provided. Moreover, peripheral blood monocytes and synovial cells are additionally fed after transplantation of synovial tissue of a patient, so a rheumatoid arthritis animal model can be more effectively produced. Accordingly, it is expected that the rheumatoid arthritis animal model remarkably contributes to the development of a rheumatoid arthritis treating agent and a treating scheme. COPYRIGHT KIPO 2016 (AA) Observe generation of new blood vessels in an engraftment region of transplanted tissue (BB) Angiogenesis ...

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Номер записи: 21
14-02-2018 дата публикации

세포 현탁액 및 메토트렉세이트를 포함하는 나노좀 형태의 면역치료제

Номер: KR0101828607B1
Автор: 박성환, 조미라, 곽승기, 박미경, 이동건, 박은미, 고용송, 김윤근, 장수철
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 세포 현탁액 및 메토트렉세이트(methotrexate)를 포함하는 나노좀 형태의 면역치료제에 관한 것이다. 본 발명의 세포 현탁액 및 메토트렉세이트(methotrexate)를 포함하는 나노좀 형태의 면역치료제는 표적부위로의 메토트렉세이트의 전달율이 높기 때문에, 메토트렉세이트 자체를 직접적으로 사용한 경우와 비교하여 염증성 사이토카인인 TNF-α의 생성을 더욱 효과적으로 억제시킬 수 있을 뿐만 아니라, 파골세포 분화 억제 효과도 뛰어나 면역질환 예방 또는 치료에서 유용하게 사용될 수 있다.

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Номер записи: 22
02-08-2017 дата публикации

COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES, COMPRISING TWEAK INHIBITOR

Номер: KR1020170088671A
Автор: PARK, SUNG HWAN, CHO, MI LA, KWOK, SEUNG KI, PARK, JIN SIL, KIM, SUNG MIN
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases, comprising a TWEAK inhibitor as an active ingredient. The TWEAK inhibitor according to the present invention can effectively treat autoimmune diseases such as arthritis and lupus by inhibiting signal transduction of TWEAK through targeting B cells. COPYRIGHT KIPO 2017 ...

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Номер записи: 23
12-10-2017 дата публикации

MYELOID DERIVED SUPPRESSOR CELLS TREATED WITH SOLUBLE PD-L1 HAVING IMMUNO-MODULATING ABILITIES AND USE THEREOF

Номер: KR1020170113279A
Автор: KWOK, SEUNG KI, CHO, MI LA, PARK, SUNG HWAN, PARK, MIN JUNG, LEE, EUN JUNG, KIM, DA SOM
Принадлежит:

The present invention relates to a medium composition for producing myeloid derived suppressor cells (MDSC) having immuno-modulating abilities comprising soluble PD-L1 as an active ingredient, a method for manufacturing MDSC having immuno-modulating abilities and a cell therapy product composition for preventing or treating immune disorders comprising MDSC as an active ingredient. According to the present invention, when soluble PD-L1 is treated to a cultivation medium of MDSC and cells are cultures, the cell number of MDSC can be increased and immuno-modulating abilities can be improved so MDSC treated with soluble PD-L1 and cultured can be used as a cell therapy product for treating immune disorders such as autoimmune diseases, inflammatory diseases and transplant rejection caused by excessive immune reaction. COPYRIGHT KIPO 2017 ...

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Номер записи: 24
16-04-2015 дата публикации

COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE, USING COMPLEX OF METFORMIN AND STATIN

Номер: WO2015053589A1
Автор: CHO, Mi-La, PARK, Sung-Hwan, PARK, Min-Jung, JHUN, Joo-Yeon, LEE, Sung-Hee, BYUN, Jae-Kyeong, JEONG, Jeong-Hee, LEE, Jeong-Ah, KWOK, Seung-Ki, LEE, Jennifer, JU, Ji-Hyeon, YANG, Chul-Woo, NA, Hyun-Sik, LEE, Eun-Jung, LEE, Seon-Yeong, YANG, Eun-Ji, SON, Hye-Jin
Принадлежит:

The present invention relates to a composition for preventing or treating autoimmune diseases, using a complex containing metformin, statin and, optionally, Coenzyme Q10. According to the present invention, a pharmaceutical composition for preventing or treating autoimmune diseases, which is the complex containing metformin, statin and, optionally, Coenzyme Q10, as active ingredients, can effectively inhibit the generation of inflammatory cytokines, can inhibit the generation of antibody-producing B cells or can reduce the activity thereof, has effects of inhibiting osteoclast differentiation and inhibiting joint destruction, and exhibits a remarkable effect of inhibiting the generation of foam cells, which generate artherosclerotic plaque progenitor cells, and thus can be useful as an agent for treating immunological diseases including autoimmune diseases.

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Номер записи: 25
14-02-2018 дата публикации

세포 현탁액 및 레티노산을 포함하는 나노좀 형태의 면역치료제

Номер: KR0101828606B1
Автор: 박성환, 조미라, 곽승기, 박미경, 이동건, 박은미, 고용송, 김윤근, 장수철
Принадлежит: 가톨릭대학교 산학협력단

... 본 발명은 레티노산(retinoic acid)을 활성성분으로 함유하는 나노좀 형태의 면역치료제에 관한 것이다. 본 발명의 레티노산을 활성성분으로 포함하는 나노좀 형태의 면역치료제는 불안정한 레티노산을 안정하게 포함할 뿐만 아니라, 표적부위로의 레티노산 전달율이 높기 때문에, 레티노산 자체를 직접적으로 사용한 경우와 비교하여 염증성 사이토카인인 TNF-α와 IL-17의 생성을 더욱 효과적으로 억제시킬 수 있으므로, 면역질환 예방 또는 치료에서 유용하게 사용될 수 있다.

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Номер записи: 26
18-06-2020 дата публикации

BIFIDOBACTERIUM LUNGUM RAPO STRAIN FOR ALLEVIATION, PREVENTION, OR TREATMENT OF RHEUMATOID ARTHRITIS AND COMPOSITION COMPRISING SAME

Номер: WO2020122396A1
Автор: JI, Geun Eog, JEONG, Yun Ju, PARK, Sang Jun, YOUNG, Su Young, LEE, Hyon Ha, PARK, Sung Hwan, CHO, Mi La, JU, Ji Hyeon, KWOK, Seung Ki, LEE, Joo Ha, KIM, Ji Won, LEE, Seon Yeong, RYU, Jun Geol, JHUN, Joo Yeon, RYU, Jae Yoon
Принадлежит:

The present invention relates to novel Bifidobacterium longum RAPO (accession number: KCTC13773BP) and can provide a composition for alleviation, prevention, or treatment of rheumatoid arthritis, the composition comprising Bifidobacterium longum RAPO (accession number: KCTC13773BP) selected in the present invention.

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Номер записи: 27
31-07-2017 дата публикации

USE OF SIGLEC5 AS MARKER FOR DIAGNOSIS OF SJOGREN′S SYNDROME

Номер: KR1020170087670A
Автор: KWOK, SEUNG KI, PARK, SUNG HWAN, LEE JENNIFER, LEE, JAE SEON, KOH, JUNG HEE
Принадлежит:

Sialic acid binding Ig-like lectin 5 (SIGLEC5), a Sjogren′s syndrome marker protein, according to the present invention, has the increased amount of expression specifically in saliva of patients with Sjogren′s syndrome compared to saliva of a normal control group to enable estimation of the levels of mRNA or SIGLEC5 protein of the SIGLEC5 in the body of the patients to diagnose the Sjogren′s syndrome in the early stage objectively and accurately, thereby having an effect of effectively preventing or treating Sjogren′s syndrome. Therefore, SIGLEC5 discovered in the present invention can be usefully used as a target for diagnosis of Sjogren′s syndrome. COPYRIGHT KIPO 2017 ...

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Номер записи: 28
02-11-2017 дата публикации

COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE CONTAINING CRIF1 AS ACTIVE INGREDIENT

Номер: KR1020170121449A
Автор: CHO, MI LA, PARK, SUNG HWAN, KWOK, SEUNG KI, KONG, YOUNG YUN, PARK, JIN SIL, KIM, SUNG MIN
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating autoimmune disease containing Crif1 as an active ingredient. According of the present invention, Crif1 suppresses symptoms of rheumarthritis, onset rate, and differentiation of osteoclast, and effectively prevents and treats symptoms of multiple sclerosis and Sjogren′s syndrome, thereby being used as a novel treatment agent for autoimmune disease. COPYRIGHT KIPO 2017 ...

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Номер записи: 29
10-10-2016 дата публикации

METHOD FOR PRODUCING ABARTASS WHICH IS SJOGREN′S SYNDROME ANIMAL MODEL THROUGH SALIVARY GLAND TISSUE TRANSPLANTATION

Номер: KR1020160116750A
Автор: PARK, SUNG HWAN, CHO, MI LA, KWEON, MI NA, KWOK, SEUNG KI, LEE, YONG SOO, KIM, SUNG MIN, PARK, JIN SIL, KIM, EUN KYUNG, KIM, NA RAE, MIN, HONG KI, LEE JENNIFER
Принадлежит:

The present invention relates to a method for producing a Sjogren′s syndrome animal model. More specifically, the present invention relates to a method for producing a Sjogren′s syndrome animal model by transplanting salivary gland tissue separated from a Sjogren′s syndrome patient and by additionally feeding peripheral-blood monocytes and salivary gland cell strains. When an animal model is produced according to the method of the present invention, an animal model for performing customized treatment can be provided. According to the present invention, a Sjogren′s syndrome animal model can be effectively produced by transplanting salivary gland tissue of a patient and by additionally feeding peripheral-blood monocytes and salivary gland cell strains, thereby remarkably contributing to the development of a Sjogren′s syndrome treating agent and a treating method. COPYRIGHT KIPO 2016 (AA) Angiogenesis ...

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Номер записи: 30