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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 14. Отображено 14.
28-12-2017 дата публикации

COMPOSITION FOR DIAGNOSIS OF CONGENITAL DYSFUNCTION AND USE THEREOF

Номер: WO2017222248A1
Автор: CHO, Eun-Hae, JANG, Ja-Hyun, LEE, Taeheon, JEON, Young-Joo, YOO, Han-Wook, KIM, Gu-Hwan, KIM, Ki Soo, LEE, So Young
Принадлежит:

The present invention relates to a composition for diagnosis of congenital dysfunction and, more specifically, to a composition for diagnosis of congenital dysfunction and a use thereof, the congenital dysfunction being selected from the group consisting of lysosomal accumulation disease, Wilson's disease, and autosomal recessive deafness 1A, the composition comprising a polynucleotide containing a sequence complementary to a sequence of a particular gene exon region. The use of the composition according to the present invention can detect, with high sensitivity and accuracy, a genetic mutation associated with congenital dysfunction in newborn babies or fetuses, and thus the composition of the present invention is useful.

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Номер записи: 1
20-07-2018 дата публикации

COOKING CONTAINER FOR MICROWAVE OVEN

Номер: KR101880704B1
Автор: YOO, HAN UK, KIM, SEUNG JIN
Принадлежит: APC TEC. CO., LTD.

An objective of the present invention is to provide a cooking container for a microwave oven which can suppress contamination of a cooking container body or the interior of a microwave oven. The cooking container for a microwave oven comprises: a container unit having an accommodation space formed therein, wherein an upper portion thereof is opened; and a lid unit coupled to an upper portion of the container unit to cover the container unit. The container unit includes a rail unit which is continuously formed along a boundary portion of the accommodation space and an edge of an upper portion of a container body, and has a protruding unit. The lid unit includes: an edge unit which is continuously formed along an edge of a lid body, and has a groove unit coupled to the protrusion unit of the rail unit; a dish unit formed on a middle portion of the lid body; a plate unit positioned between the edge unit and the dish unit; and a steam discharge unit, which is positioned at a height equal to ...

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Номер записи: 2
14-07-2015 дата публикации

PRIMER SET FOR DIAGNOSING BECKWITH-WIEDEMANN SYNDROME OR RUSSEL-SILVER SYNDROME, AND COMPOSITION FOR DIAGNOSING BECKWITH-WIEDEMANN SYNDROME OR RUSSEL-SILVER SYNDROME, KIT, AND DIAGNOSIS METHOD BY USING SAME

Номер: KR1020150081389A
Автор: YOO, HAN WOOK, LEE, BEOM HEE, KIM, GU HWAN
Принадлежит:

The present invention relates to a primer set for diagnosing Beckwith-Wiedemann syndrome or Russel-Silver syndrome, and a composition for diagnosing Beckwith-Wiedemann syndrome or Russel-Silver syndrome, a kit, and a diagnosis method by using the same. Accordingly, the present invention can increase a detection rate of Beckwith-Wiedemann syndrome and Russel-Silver syndrome to 97% and 70%, respectively, using a methylation specific primer through pyro DNS sequence analysis, thereby increasing a rate of genetic diagnosis of Beckwith-Wiedemann syndrome and Russel-Silver syndrome. Therefore, the primer set, and the composition for diagnosis, the kit, and the diagnosis method comprising the same can be effectively used in diagnosing Beckwith-Wiedemann syndrome and Russel-Silver syndrome. COPYRIGHT KIPO 2015 ...

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Номер записи: 3
11-10-2018 дата публикации

COMPOSITION COMPRISING GENOMIC DNA-BASED LONG PCR PRIMER SET FOR DIAGNOSING NEUROFIBROMATOSIS

Номер: WO2018186680A1
Автор: YOO, Han-Wook, KIM, Gu-Hwan, LEE, Beom Hee, KIM, Jae-Min
Принадлежит:

The present invention relates to a composition comprising a genomic DNA-based long PCR primer set for diagnosing neurofibromatosis and a method for diagnosing neurofibromatosis using the same. The present inventors designed primers that are based on genomic DNA and do not allow the concomitant amplification of a pseudo-homologous sequence and conducted a long PCR, followed by re-amplifying the fragment into short fragments in the presence of multiple primers and then base sequencing the fragments. Through the genomic DNA-based gene assay, a diagnostic yield of 94 % could be secured in 88 patients. Therefore, the primer sets are predicted to be usefully applied to the diagnosis of neurofibromatosis.

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Номер записи: 4
06-12-2018 дата публикации

Composition for diagnosis of neurofibromatosis comprising long PCR primer set based on genomic DNA

Номер: KR0101925974B1
Автор: 유한욱, 김구환, 이범희, 김재민
Принадлежит: 울산대학교 산학협력단, 재단법인 아산사회복지재단

... 본 발명은 게놈 DNA 기반의 장(long) PCR 프라이머 세트 포함하는 신경섬유종증 진단용 조성물 및 이를 이용한 신경섬유종증 진단방법에 관한 것으로서, 본 발명자들은 게놈 DNA에 기반하되 거짓 상동 염기서열이 동시에 증폭되지 않도록 프라이머를 고안하여, 장 PCR을 한 후 이 절편을 다중 프라이머로 작은 절편으로 재증폭한 후 이 절편들의 염기서열을 분석하였다. 이 게놈 DNA에 기반한 유전자 분석법을 통하여 88명의 환자를 대상으로 94%의 진단률을 확보할 수 있었다. 따라서, 상기 프라이머 세트들은 신경섬유종증 진단에 있어 유용하게 활용될 수 있을 것으로 예상된다.

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Номер записи: 5
31-10-2018 дата публикации

파브리병 진단용 바이오마커 및 이의 용도

Номер: KR0101913199B1
Автор: 유한욱, 이범희, 김구환, 허선희
Принадлежит: 울산대학교 산학협력단, 재단법인 아산사회복지재단

... 본 발명은 파브리병 (Fabry disease)에 대한 효소 치료의 효과를 평가하기 위한 조성물 및 파브리병 진단용 조성물, 상기 조성물을 포함하는 키트, 및 상기 조성물을 이용하여 파브리병에 대한 효소 치료의 효과를 평가하거나 파브리병을 진단하기 위한 정보를 제공하는 방법에 관한 것이다. 본 발명에서는 파브리병의 진단 및 치료 효과 평가와 관련된 신규 바이오 마커로서 불활성 보체 요소 3b (inactive complement component 3b, iC3b)를 발굴하였다. 상기 iC3b는 정상 대조군에 비해 파브리병 환자에서 발현 수준이 높아 이를 이용해 파브리병을 진단할 수 있으며, 나아가 효소 치료 후 장기적으로 상기 마커의 발현 양상이 점진적으로 변하므로, 파브리병 치료 과정에서 질환의 자연경과와 치료 효과를 판명하는데 중요한 바이오 마커로 사용될 수 있다.

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Номер записи: 6
04-01-2018 дата публикации

COMPOSITION FOR DIAGNOSING CONGENITAL DYSFUNCTION AND USE THEREOF

Номер: KR1020180001442A
Автор: CHO, EUN HAE, JANG, JA HYUN, LEE, TAE HEON, JEON, YOUNG JOO, YOO, HAN WOOK, KIM, GU HWAN, KIM, KI SOO, LEE, SO YOUNG
Принадлежит:

The present invention relates to a composition for diagnosing congenital dysfunction and, more specifically, to a composition for diagnosing congenital dysfunction selected from the group consisting of lysosomal storage disorder, Wilson disease and autosomal 1A recessive deafness by comprising polynucleotides containing complementary sequences in a specific gene exon area sequence, and to uses thereof. The composition according to the present invention is useful by detecting gene mutation associated with congenital dysfunction in newborn infants or embryos with high sensitivity and accuracy. COPYRIGHT KIPO 2018 ...

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Номер записи: 7
09-01-2018 дата публикации

선천성 기능장애 진단용 조성물 및 이의 용도

Номер: KR0101816921B1
Автор: 조은해, 장자현, 이태헌, 전영주, 유한욱, 김구환, 김기수, 이소영
Принадлежит: 주식회사 녹십자지놈, 주식회사 녹십자엠에스

... 본 발명은 선천성 기능장애 진단용 조성물에 관한 것으로, 더욱 자세하게는 특정 유전자 엑손 영역 서열에 상보적인 서열을 함유하는 폴리뉴클레오타이드를 포함하는 라이소좀 축적질환, 윌슨병 및 상염색체 1A 열성 난청으로 구성된 군으로부터 선택되는 선천성 기능장애 진단용 조성물 및 이의 용도에 관한 것이다. 본 발명에 따른 조성물을 이용하면, 신생아 또는 태아에서 선천성 기능장애와 관련된 유전자 변이를 높은 민감도와 정확도 검출할 수 있어 유용하다.

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Номер записи: 8
28-09-2017 дата публикации

BIOMARKER FOR DIAGNOSING FABRY DISEASE AND USE THEREOF

Номер: KR1020170109214A
Автор: YOO, HAN WOOK, LEE, BEOM HEE, KIM, GU HWAN, HEO, SUN HEE
Принадлежит:

The present invention relates to a composition for evaluating an effect of an enzyme treatment on a Fabry disease and a composition for diagnosing a Fabry disease, a kit containing the composition, and a method for evaluating the effect of enzyme treatment on the Fabry disease using the composition. In the present invention, an inactive complement component 3b (iC3b) has been discovered as a new biomarker related to a diagnosis and therapeutic effect evaluation of the Fabry disease. An expression level of the iC3b in the Fabry disease is higher than that of normal control, so that the Fabry disease can be diagnosed using the same, and furthermore, an expression pattern of the marker gradually changes in a long term after the treatment with enzyme, which can be used as an important biomarker to elucidate the progress and therapeutic effect. COPYRIGHT KIPO 2017 (A1,A2) Fabry disease patient 1 (B1,B2) Fabry disease patient 2 (C1,C2) Fabry disease patient 3 (D1,D2) Fabry disease patient 4 ( ...

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Номер записи: 9
30-01-2018 дата публикации

COMPOSITION FOR DETECTING INBORN ERROR OF METABOLISM AND USE THEREOF

Номер: KR1020180009998A
Автор: CHO, EUN HAE, JANG, JA HYUN, LEE, TAE HEON, JEON, YOUNG JOO, YOO, HAN WOOK, KIM, KI SOO, LEE, SO YOUNG
Принадлежит:

The present invention relates to a composition for detecting inborn error of metabolism and, more specifically, to a composition for detecting inborn error of metabolism comprising polynucleotide containing a complementary sequence in a specific gene exon area sequence, and uses thereof. The composition according to the present invention is useful for detecting genetic mutation associated with inborn error of metabolism in newborn infants or the fetus with high sensitivity and accuracy. COPYRIGHT KIPO 2018 ...

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Номер записи: 10
04-01-2018 дата публикации

COMPOSITION FOR DIAGNOSING CONGENITAL DYSFUNCTION AND USE THEREOF

Номер: KR1020180001437A
Автор: CHO, EUN HAE, JANG, JA HYUN, LEE, TAE HEON, JEON, YOUNG JOO, YOO, HAN WOOK, KIM, GU HWAN, KIM, KI SOO, LEE, SO YOUNG
Принадлежит:

The present invention relates to a composition for diagnosing congenital dysfunction and, more specifically, to a composition for diagnosing congenital dysfunction selected from the group consisting of lysosomal storage disorder, Wilson disease and autosomal 1A recessive deafness by comprising polynucleotides containing complementary sequences in a specific gene exon area sequence, and to uses thereof. The composition according to the present invention is useful for detecting gene mutation associated with congenital dysfunction in newborn infants or embryos with high sensitivity and accuracy. COPYRIGHT KIPO 2018 ...

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Номер записи: 11
15-06-2017 дата публикации

COMPOSITION FOR DIAGNOSING CONGENITAL DYSFUNCTION AND USE THEREOF

Номер: KR101743211B1
Автор: CHO, EUN HAE, JANG, JA HYUN, LEE, TAE HEON, JEON, YOUNG JOO, YOO, HAN WOOK, KIM, GU HWAN, KIM, KI SOO, LEE, SO YOUNG
Принадлежит: GREEN CROSS GENOME CORPORATION, GREEN CROSS MEDICAL SCIENCE

The present invention relates to a composition for diagnosing congenital dysfunction and, more specifically, to a composition for diagnosing congenital dysfunction selected from the group consisting of lysosomal storage diseases, Wilson′s disease and autosomal recessive deafness 1A, comprising polynucleotide, wherein the polynucleotide has a complementary sequence in a specific gene exon sequence and to sues thereof. By using the composition according to the present invention, genetic mutation involved in congenital dysfunction of newborn infants or embryos can be detected with high sensitivity and accuracy. COPYRIGHT KIPO 2017 ...

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Номер записи: 12
25-01-2018 дата публикации

COMPOSITION FOR DIAGNOSING CONGENITAL FUNCTIONAL DISORDER, AND USE THEREOF

Номер: WO2018016884A1
Автор: CHO, Eun-Hae, JANG, Ja-Hyun, LEE, Taeheon, JEON, Young-Joo, YOO, Han-Wook, KIM, Ki Soo, LEE, So Young, KIM, Young-Eun, LEE, Junnam, KIM, Gu-Hwan, LIM, Chae Hyun, KIM, Min jung, HWANG, Tai-Ju, YOO, Ki-Young
Принадлежит:

The present invention relates to a composition for diagnosing congenital functional disorders and, more particularly, to: a composition for diagnosing congenital functional disorders, in which a polynucleotide containing a sequence that is complementary to a sequence in an exon region of a particular gene is selected from the group consisting of Inherited Bleeding Coagulation Disorders (IBCD), Inborn Error Of Metabolism (IEM), and RASopathies (RAS); and a use thereof. The composition according to the present invention is useful in that gene mutations related to congenital functional disorders in infants or fetuses can be detected with high sensitivity and accuracy when the composition is used.

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Номер записи: 13
10-06-2016 дата публикации

Primer set for diagnosis of BeckwithWiedemann syndrome or Silver-Russel syndrome, Kit comprising the same, and Method of diagnosis using the same

Номер: KR0101628834B1
Автор: 유한욱, 이범희, 김구환
Принадлежит: 재단법인 아산사회복지재단, 울산대학교 산학협력단

... 본 발명은 베크위드-위드만 (BeckwithWiedemann) 증후군 또는 실버 러셀 Silver-Russel) 증후군 진단용 프라이머 세트, 이를 이용한 베크위드-위드만 증후군 또는 러셀 실버 증후군 진단용 조성물, 키트 및 진단방법에 관한 것이다. 이에 본 발명은 메칠화 특이적 프라이머를 사용하여 파이로염기서열분석을 통해 베크위드-위드만 증후군과 실버 러셀 증후군을 각각 97%, 70%로 검출율을 높이는 효과가 있는바, 이는 베크위드-위드만 증후군과 실버 러셀 증후군의 유전학적 진단율을 높일 수 있다. 따라서 본 발명의 프라이머 세트, 이를 포함한 진단용 조성물, 키트 및 진단방법은 베크위드-위드만 증후군과 실버 러셀 증후군을 진단하는데 유용하게 사용될 수 있다.

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Номер записи: 14