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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 23. Отображено 23.
20-11-2017 дата публикации

피롤리딘 카복스아미도 유도체 및 이의 제조 방법 및 용도

Номер: KR1020170127000A
Автор: 이광호, 이상달, 최길돈, 알리 임란, 채종학, 전문국, 박석희, 이연숙
Принадлежит:

... 본 발명은 염증성 장 질환을 포함하는 염증성 질환을 예방하고/하거나 개선하고/하거나 치료하는 피롤리딘 카복스아미도 유도체, 이의 광학적 이성질체 또는 이의 염 및 이들의 제조 방법 및 용도를 제공한다.

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Номер записи: 1
07-09-2018 дата публикации

PIPERIDINE-ARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

Номер: WO2018160024A1
Автор: AHN, Jin Hee, BAE, Eun Jung, LEE, In-Kyu, JEON, Jae-Han, KANG, Seung Kyu, LEE, Kyu-Myung, JEONG, Kwan Young, JANG, Yoon Kyung, KIM, Kwang-Rok, RHEE, Sang Dal, BAE, Myung-Ae, KIM, Hyojin
Принадлежит:

The present invention relates to: a piperidine-aryl derivative having G-protein-coupled receptor (G-protein-coupled receptor 119; GPR119) agonist activity, or a pharmaceutically acceptable salt thereof; a method for preparing same; and a pharmaceutical composition containing same as an active ingredient.

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Номер записи: 2
15-11-2012 дата публикации

THIENOPYRIMIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING THIENOPYRIMIDINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION CONTAINING THIENOPYRIMIDINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING OR TREATING DIABETES-RELATED DISEASES

Номер: WO2012154009A2
Автор: JEON, Moon Kook, AHN, Jin Hee, KANG, Seung Kyu, LEE, Kyu Myung, RHEE, Sang Dal, KIM, Hi Youn, JUNG, Won Hoon, KIM, Kwang Rok, BAE, Myung-Ae, SONG, Jin Sook, SUH, Jee Hee, KANG, Myoung Ku, KIM, Min Hye
Принадлежит:

The present invention relates to novel thienopyrimidine derivatives, and to a pharmaceutical composition containing thienopyrimidine derivatives as active ingredients for preventing or treating diabetes or various diabetes-related diseases. The thienopyrimidine derivatives of the present invention efficiently accelerate the activity of G protein-coupled receptor 119 (GPR119), which has the effects of increasing glucose-dependent insulin secretion and inhibiting increases in appetite and body weight, thus enhancing glucose metabolism and lipid metabolism. Therefore, the thienopyrimidine derivatives of the present invention may be valuably used in a composition for efficiently preventing and treating not only diabetes but also various complications of diabetes such as obesity, hyperlipidemia, and diabetic vascular diseases.

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Номер записи: 3
03-04-2014 дата публикации

COMPOSITION COMPRISING SULFAMIDE DERIVATIVE HAVING ADAMANTYL GROUP AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING BRAIN DISEASES OR ISCHEMIC HEART DISEASES

Номер: WO2014051388A1
Автор: KIM, Ki Young, KWAK, Hyun Jung, KANG, Seung Kyu, RHEE, Sang Dal, KIM, Hi Youn, JUNG, Won Hoon, AHN, Sung Hoon, LEE, Byung Ho, LEE, Jeong Hyun, SEO, Ho Won, OH, Kwang Seok
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a sulfamide derivative having an adamantyl group as an active ingredient for preventing or treating brain diseases or ischemic heart diseases. The sulfamide derivative compound having an adamantyl group according to the present invention may efficiently inhibit the activity of 11β-HSD1, and therefore, can be effectively used in preventing or treating not only ischemic heart diseases but also various 11β-HSD1-mediated brain diseases such as neurodegenerative diseases, cerebrovascular diseases caused by ischemia or reperfusion and mental diseases.

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Номер записи: 4
30-10-2017 дата публикации

아다만틸기를 갖는 헤테로고리 카복스아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물

Номер: KR0101791501B1
Автор: 김기영, 이상달, 김희연, 정원훈, 안진희, 강승규, 서지희, 배명애, 신대섭, 유욱준, 이진수, 김원태, 정지성, 김영훈, 배현주, 이주희, 양은영, 오세환, 김영하
Принадлежит: 한국화학연구원, 국제약품 주식회사

... 본 발명은 11β-하이드록시스테로이드 디하이드로게나제 타입 1(11β-hydroxystreroid dehydrogenase type1,11β-HSD1)의 활성을 억제하는 하기 화학식 1로 표시되는 아다만틸기를 갖는 헤테로고리 카복스아미드 유도체, 그의 프로드럭, 그의 용매화물, 그의 입체이성질체 또는 약제학적으로 허용 가능한 그의 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물에 관한 것이다. [화학식 1] 상기 화학식 1에서, W, X, R1, R2, L, a 및 b은 발명의 상세한 설명에서 정의한 바와 같다.

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Номер записи: 5
22-04-2010 дата публикации

Ｎ1-2-THIOPHENE-2-YLETHYL-Ｎ2-SUBSTITUTED  BIGUANIDE DERIVATE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENTS

Номер: WO2010044582A2
Автор: KIM, Sung Wuk, JUN, Sung Soo, CHEON, Hyae Gyeong, KIM, Kwang Rok, RHEE, Sang Dal, JUNG, Won Hoon, LEE, Jong Cheol
Принадлежит:

The present invention relates to an Ｎ1-2-thiophene-2-ylethyl-Ｎ2-substituted biguanide derivate expressed in Chemical Formula 1, a pharmaceutically allowable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same as active ingredients. The Ｎ1-2-thiophene-2-ylethyl-Ｎ2-substituted biguanide derivate of the present invention shows a superior hypoglycemic action and a superior hypolipidemic action even at a low dosage as compared with conventional drugs, and thus can be used for prevention and treatment of diabetes, non-insulin-dependent diabetes, obesity, the metabolic syndrome and arteriosclerosis, or cancer involving P53 gene deficiency.

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Номер записи: 6
14-12-2017 дата публикации

ENDOSCOPIC RETRACTOR FOR BREAST SURGERY

Номер: WO2017213300A1
Автор: LEE, Sang-Dal
Принадлежит:

The present invention relates to an endoscopic retractor for breast surgery, comprising: a traction part which is formed in a form of a linear flat plate long in one direction and is to be inserted into a surgical site; a first horizontal support part which is fixed to a lower portion of one side of the traction part; a vertical support part which is bent and extends in a vertical direction from an end portion of the first horizontal support part; a second horizontal support part which is bent in a horizontal direction from an end portion of the vertical support part and extends in a direction of the traction part; an inclined support part which is bent in an oblique direction from an end portion of the second horizontal support part and extends in a direction of the second horizontal support part; and a gripping handle disposed at the inclined support part.

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Номер записи: 7
05-09-2018 дата публикации

PIPERIDINE-ARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPRATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

Номер: KR1020180099571A
Автор: JIN HEE AHN, IN KYU LEE, KANG SEUNG KYU, BAE EUN JUNG, LEE KYU MYUNG, JAE HAN JEON, KWAN YOUNG JEONG, JANG YOON KYUNG, KWANG ROK KIM, BAE MYUNG AE, SANG DAL RHEE, KIM HYO JIN
Принадлежит:

The present invention relates to a piperidine-aryl derivative which has the hyperactivity of G protein-coupled receptor 119 (GPR119) or pharmaceutically acceptable salt thereof; to a preparation method of the same; and to a pharmaceutical composition containing the same as an active ingredient. An objective of the present invention is to provide the pharmaceutical composition containing a piperidine-aryl derivative or pharmaceutically acceptable salt as an effective component for preventing or treating diseases related to the hyperactivity of GPR119. COPYRIGHT KIPO 2018 ...

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Номер записи: 8
26-01-2017 дата публикации

THREE-DIMENSIONAL CO-CULTURE METHOD FOR ADIPOCYTES AND MACROPHAGES

Номер: WO2017014595A1
Автор: KIM, Ki Young, PARK, Sung Bum, RHEE, Sang Dal, KIM, Hi Youn, JUNG, Won Hoon
Принадлежит:

The present invention relates to a three-dimensional co-culture of adipocytes and macrophages, wherein, in a hydrogel scaffold containing adipocytes and macrophages, the adipocytes and the macrophages are co-cultured to form a fat-like tissue, which can be then utilized in the studies and medicine development for treating metastatic diseases associated with adipose tissue.

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Номер записи: 9
22-04-2010 дата публикации

Ｎ1-2-THIOPHENE-2-YLETHYL-Ｎ2-SUBSTITUTED BIGUANIDE DERIVATE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENTS

Номер: WO2010044582A3
Автор: KIM, Sung Wuk, JUN, Sung Soo, CHEON, Hyae Gyeong, KIM, Kwang Rok, RHEE, Sang Dal, JUNG, Won Hoon, LEE, Jong Cheol
Принадлежит:

The present invention relates to an Ｎ1-2-thiophene-2-ylethyl-Ｎ2-substituted biguanide derivate expressed in Chemical Formula 1, a pharmaceutically allowable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same as active ingredients. The Ｎ1-2-thiophene-2-ylethyl-Ｎ2-substituted biguanide derivate of the present invention shows a superior hypoglycemic action and a superior hypolipidemic action even at a low dosage as compared with conventional drugs, and thus can be used for prevention and treatment of diabetes, non-insulin-dependent diabetes, obesity, the metabolic syndrome and arteriosclerosis, or cancer involving P53 gene deficiency.

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Номер записи: 10
11-12-2015 дата публикации

A composition for promoting hair growth and hair loss prevention containing triazole derivatives and cosmetic composition for promoting hair growth hair and loss prevention

Номер: KR0101577053B1
Автор: 김성수, 이상달, 김광록, 김희연, 송종환, 채종학, 김범태, 이혁, 정주미
Принадлежит: 한국화학연구원

... 본 발명은 트리아졸을 유도체를 함유하는 탈모 예방 또는 발모 촉진용 조성물 및 화장료 조성물에 관한 것으로, 본 발명의 탈모 예방 또는 발모 촉진용 조성물 및 화장료 조성물은 피부 자극성이 없으면서도 우수한 발모 촉진효과를 나타내탈모 예방 또는 탈모증 치료에 매우 효과적이다.

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Номер записи: 11
31-10-2013 дата публикации

NOVEL BETA-ALANINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT

Номер: WO2013162298A8
Автор: AHN, Jin Hee, H. S. Pagire, RHEE, Sang Dal, KIM, Ki Young, JUNG, Won Hoon, BAE, Myung-Ae, SONG, Jin Sook, KIM, Kwang-Rok, KWAK, Hyun Jung
Принадлежит:

The present invention relates to novel beta-alanine derivatives, to the pharmaceutically acceptable salts thereof, and to a pharmaceutical composition comprising same as an active ingredient. The novel beta-alanine derivatives and pharmaceutically acceptable salts thereof according to the present invention may effectively inhibit the activity of DGAT1, which is an enzyme serving as a catalyst in the final step of the synthesis of neutral lipids, and therefore can be effectively used as a pharmaceutical composition for preventing or treating various diseases relating to lipid metabolism belonging to the group consisting of obesity, dyslipidemia, fatty liver, insulin resistance syndrome, and hepatitis.

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Номер записи: 12
31-10-2013 дата публикации

NOVEL BETA-ALANINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT

Номер: WO2013162298A1
Автор: AHN, Jin Hee, KANG, Seung Kyu, H. S. Pagire, RHEE, Sang Dal, KIM, Ki Young, JUNG, Won Hoon, BAE, Myung-Ae, SONG, Jin Sook, CHAE, Chong Hak, AHN, Sung Hoon, KIM, Kwang-Rok
Принадлежит:

The present invention relates to novel beta-alanine derivatives, to the pharmaceutically acceptable salts thereof, and to a pharmaceutical composition comprising same as an active ingredient. The novel beta-alanine derivatives and pharmaceutically acceptable salts thereof according to the present invention may effectively inhibit the activity of DGAT1, which is an enzyme serving as a catalyst in the final step of the synthesis of neutral lipids, and therefore can be effectively used as a pharmaceutical composition for preventing or treating various diseases relating to lipid metabolism belonging to the group consisting of obesity, dyslipidemia, fatty liver, insulin resistance syndrome, and hepatitis.

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Номер записи: 13
22-04-2010 дата публикации

N1-BENZO[1,3]DIOXOL-5-YLMETHYL-N2-SUBSTITUTED BIGUANIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: WO2010044581A3
Автор: KIM, Sung Wuk, JUN, Sung Soo, CHEON, Hyae Gyeong, KIM, Kwang Rok, RHEE, Sang Dal, JUNG, Won Hoon, LEE, Jong Cheol
Принадлежит:

The present invention relates to an N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative expressed in chemical formula 1, to a pharmaceutically acceptable salt thereof, to a preparation method thereof, and to a pharmaceutical composition containing the same as an active ingredient. The N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative of the present invention shows superior hypoglycemic action and superior hypolipidemic action even at a lower dosage as compared with conventional drugs, and thus can be used for the prevention and treatment of metabolic syndrome disorders such as diabetes, non-insulin-dependent diabetes, obesity, arteriosclerosis, and the like, or cancer involving P53 gene deficiency.

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Номер записи: 14
28-05-2015 дата публикации

COMPOSITION AND COSMETIC COMPOSITION INCLUDING TRIAZOLE DERIVATIVES FOR PREVENTING HAIR LOSS AND PROMOTING HAIR GROWTH

Номер: KR1020150057582A
Автор: KIM, SUNG SOO, RHEE, SANG DAL, KIM, KWANG ROK, KIM, HI YOUN, SONG, JONG HWAN, CHAE, CHONG HAK, KIM, BUM TAE, LEE, HYUK, JEONG, JU MI
Принадлежит:

The present invention relates to a composition and a cosmetic composition including triazole derivatives for preventing hair loss and promoting hair growth. The composition and the cosmetic composition do not irritate skin, have an excellent effect of promoting hair growth, and thus are every effective for preventing or treating hair loss. COPYRIGHT KIPO 2015 (AA) Representative 1 ...

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Номер записи: 15
10-07-2017 дата публикации

HETEROCYCLIC CARBOXAMIDE DERIVATIVES HAVING ADAMANTYL GROUP, PREPARATION METHOD OF SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT

Номер: KR1020170079939A
Автор: KIM, KI YOUNG, RHEE, SANG DAL, KIM, HI YOUN, JUNG, WON HOON, AHN, JIN HEE, KANG, SEUNG KYU, SUH, JEE HEE, BAE, MYUNG AE, SHIN, DAE SEOP, YU, WOOK JOON, LEE, JIN SOO, KIM, WON TAE, JEONG, JI SEONG, KIM, YOUNG HOON, BAE, HYUN JU, LEE, JU HEE, YANG, EUN YEONG, OH, SE HWAN, KIM, YOUNG HA
Принадлежит:

The present invention relates to a heterocyclic carboxamide derivative having an adamantyl group represented by chemical formula 1 which inhibits the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a prodrug of the same, a solvate of the same, a stereoisomer or a pharmaceutically acceptable salt of the same, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. In the chemical formula 1, W, X, R_1, R_2, L, a, and b are as defined in the specification of the present invention. COPYRIGHT KIPO 2017 ...

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Номер записи: 16
31-10-2016 дата публикации

케톤펩타이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 또는 치료용 약학적 조성물

Номер: KR0101670317B1
Автор: 이광호, 이상달, 최길돈, 전문국, 채종학, 안성훈, 알리 임란, 박석희, 이연숙
Принадлежит: 한국화학연구원, 성균관대학교산학협력단

... 본 발명은 케톤펩타이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 염증성 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 케톤펩타이드 유도체, 이의 광학 이성질체, 또는 이의 약학적으로 허용 가능한 염은 인터루킨-6(Interleukin-6, IL-6)의 발현을 억제하는 활성이 우수하므로, 궤양성 대장염(Ulcerative colitis), 크론씨병 (Crohns disease) 등의 염증성 장질환 (Inflammatory bowel disease), 또는 패혈증(Sepsis) 등 인터루킨-6로 인하여 유발되는 염증성 질환의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.

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Номер записи: 17
13-05-2016 дата публикации

KETONEPEPTIDE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING INFLAMMATORY DISEASES

Номер: KR1020160052892A
Автор: LEE, KWANG HO, RHEE, SANG DAL, CHOI, GIL DON, JEON, MOON KOOK, CHAE, CHONG HAK, AHN, SUNG HOON, ALI IMRAN, PARK, SEOK HEE, LEE, YOUN SOOK
Принадлежит:

The present invention relates to ketonepeptide derivatives, a preparation method thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating inflammatory diseases, wherein ketonepeptide derivatives of the present invention, optical isomers thereof, and pharmaceutically acceptable salts thereof have an excellent inhibitory activity against the expression of Interleukin-6 (IL-6), and therefore, can be advantageously used as a pharmaceutical composition for preventing or treating inflammatory diseases induced by IL-6, such as ulcerative colitis, Crohn′s disease, inflammatory bowel disease, and sepsis. COPYRIGHT KIPO 2016 (AA) Interleukin-6/GAPDH (BB) Example (CC) Group treated with Lipopolysaccharides (LPS) (DD) Group treated with Smaducin-6 and then treated with LPS (EE) Group treated with Transforming Growth Factor Beta (TGF-b) and then treated with LPS ...

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Номер записи: 18
15-11-2012 дата публикации

THIENOPYRIMIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING THIENOPYRIMIDINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION CONTAINING THIENOPYRIMIDINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING OR TREATING DIABETES-RELATED DISEASES

Номер: WO2012154009A3
Автор: JEON, Moon Kook, AHN, Jin Hee, KANG, Seung Kyu, LEE, Kyu Myung, RHEE, Sang Dal, KIM, Hi Youn, JUNG, Won Hoon, KIM, Kwang Rok, BAE, Myung-Ae, SONG, Jin Sook, SUH, Jee Hee, KANG, Myoung Ku, KIM, Min Hye
Принадлежит:

The present invention relates to novel thienopyrimidine derivatives, and to a pharmaceutical composition containing thienopyrimidine derivatives as active ingredients for preventing or treating diabetes or various diabetes-related diseases. The thienopyrimidine derivatives of the present invention efficiently accelerate the activity of G protein-coupled receptor 119 (GPR119), which has the effects of increasing glucose-dependent insulin secretion and inhibiting increases in appetite and body weight, thus enhancing glucose metabolism and lipid metabolism. Therefore, the thienopyrimidine derivatives of the present invention may be valuably used in a composition for efficiently preventing and treating not only diabetes but also various complications of diabetes such as obesity, hyperlipidemia, and diabetic vascular diseases.

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Номер записи: 19
13-11-2017 дата публикации

NOVEL INDAZOLE DERIVATIVE, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING SAME AS ACTIVE INGREDIENT

Номер: KR101796781B1
Автор: JEON, MOON KOOK, CHOI, GIL DON, LEE KWANGHO, RHEE, SANG DAL, GU, SU JIN, HEO, YUN JEONG, JUNG, MYOUNG EUN, KIM, NAM SOON, CHO, HYUN SOO, YOON, JI YONG, LEE, JEONG JU, JUN, SOO YOUNG, JUNG, CHO ROK
Принадлежит: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

The present invention relates to a novel indazole derivative, a production method thereof, and a pharmaceutical composition for preventing or treating cancer containing the same as an active ingredient. According to the present invention, the compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof shows outstanding inhibitory activities on TRAIL-resistance regarding cancer which is resistant to tumor necrosis factor related apoptosis (TRAIL), and thus can be useful for preventing and treating cancer when used as a pharmaceutical composition containing the same as the active ingredient in conjunction with TRAIL. COPYRIGHT KIPO 2017 (AA) Cancer cell survival rate (BB) Compound alone (CC) Compound + TRAIL (DD) Example 10 ...

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Номер записи: 20
09-03-2016 дата публикации

PEPTIDE DERIVATIVE, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT

Номер: KR101600613B1
Автор: LEE, KWANG HO, RHEE, SANG DAL, CHOI, GIL DON, JEON, MOON KOOK, CHAE, CHONG HAK, AHN, SUNG HOON, PARK, SANG JUN, ALI IMRAN, PARK, SEOK HEE, LEE, YOUN SOOK
Принадлежит: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

The present invention relates to a peptide derivative, a production method thereof, and a pharmaceutical composition for preventing or treating inflammatory diseases, containing the same as an active ingredient. According to the present invention, the peptide derivative, an optical isomer thereof, or a pharmaceutically acceptable salt thereof has excellent activity of inhibiting the expression of interleukin-6 (IL-6). Thus, the peptide derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof can be useful as a pharmaceutical composition for preventing or treating IL-6-induced inflammatory diseases such as sepsis or inflammatory bowel diseases such as ulcerative colitis and Crohn′s disease. COPYRIGHT KIPO 2016 (AA) Interleukin-6/GAPDH (BB) Example (CC) - : Untreatd group (DD) LPS: Group treated with Lipopolysaccharides, LPS (EE) Smaducin-6/LPS : Group treatd with LPS, after treating Smaducin-6 (FF) TGF-b/LPS: Group treated with LPS, after treating Transforming ...

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Номер записи: 21
22-04-2010 дата публикации

N1-BENZO[1,3]DIOXOL-5-YLMETHYL-N2-SUBSTITUTED BIGUANIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: WO2010044581A2
Автор: KIM, Sung Wuk, JUN, Sung Soo, CHEON, Hyae Gyeong, KIM, Kwang Rok, RHEE, Sang Dal, JUNG, Won Hoon, LEE, Jong Cheol
Принадлежит:

The present invention relates to an N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative expressed in chemical formula 1, to a pharmaceutically acceptable salt thereof, to a preparation method thereof, and to a pharmaceutical composition containing the same as an active ingredient. The N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative of the present invention shows superior hypoglycemic action and superior hypolipidemic action even at a lower dosage as compared with conventional drugs, and thus can be used for the prevention and treatment of metabolic syndrome disorders such as diabetes, non-insulin-dependent diabetes, obesity, arteriosclerosis, and the like, or cancer involving P53 gene deficiency.

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Номер записи: 22
02-02-2017 дата публикации

METHOD FOR THREE-DIMENSIONAL CO-CULTURE OF ADIPOCYTES WITH MACROPHAGES

Номер: KR1020170011522A
Автор: KIM, KI YOUNG, PARK, SUNG BUM, RHEE, SANG DAL, KIM, HI YOUN, JUNG, WON HOON
Принадлежит:

The present invention relates to a method for three-dimensional co-culture of preadipocytes with macrophages. According to the present invention, preadipocytes and macrophages are co-cultured in a hydrogel scaffold comprising the preadipocytes and macrophages, to form fat-like tissues. Also, the method can be used for research and new medicine development for treating metabolic diseases related to fat tissues. COPYRIGHT KIPO 2017 ...

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Номер записи: 23