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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 15. Отображено 15.
02-01-2020 дата публикации

METHOD FOR PREPARING PNA OLIGOMER

Номер: WO2020004980A1
Автор: PARK, Heekyung, HONG, In Seok, JOE, Goon Ho, KIM, Yongtae
Принадлежит:

The present invention provides a method for preparing a PNA oligomer. More specifically, the present invention can prepare a PNA oligomer which is easily separable from byproducts through a simple and short process by using PNA dimers, PNA trimers or PNA tetramers, and which has extremely high yields and purity.

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Номер записи: 1
17-01-2013 дата публикации

COMPOSITION FOR SIMULTANEOUSLY DETECTING MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA BY MEANS OF REAL-TIME MULTIPLEX POLYMERASE CHAIN REACTION COMPRISING NESTED HYBRIDIZATION PNA PROBE SYSTEM HAVING PARALLEL BINDING STRUCTURE, AND METHOD FOR DETECTION USING SAME

Номер: WO2013009084A9
Автор: KIM, Sung-Kee, PARK, Chwang Siek, JOE, Goon Ho, PARK, Heekyung, KIM, Jihyun, CHOI, Ji-Ah, CHOI, Sung Rok, KIM, Su Nam, KIM, Yongtae, KIM, Se Ryun, JANG, Hyunjung
Принадлежит:

The present invention relates to a composition for simultaneously detecting Mycobacterium tuberculosis and nontuberculous mycobacteria based on a nested hybridization peptide nucleic acid (PNA) probe system having a parallel binding structure, and to a method for simultaneously detecting Mycobacterium tuberculosis and nontuberculous mycobacteria using the composition and real-time polymerase chain reaction. Also, the present invention relates to a primer, a probe composition, and a method for analyzing to simultaneously detect Mycobacterium tuberculosis and nontuberculous mycobacteria based on the nested hybridization PNA probe system having the parallel binding structure. When carrying out the real-time multiplexed polymerase chain reaction by using the composition comprising the nested hybridized PNA probe system having the parallel binding structure, according to the present invention, Mycobacterium tuberculosis and nontuberculous mycobacteria can be simultaneously and accurately detected ...

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Номер записи: 2
17-01-2013 дата публикации

NESTED HYBRIDIZATION PNA PROBE SYSTEM HAVING PARALLEL BINDING STRUCTURE

Номер: WO2013009070A9
Автор: KIM, Sung-Kee, PARK, Chwang Siek, JOE, Goon Ho, PARK, Heekyung, CHOI, Ji-Ah, CHOI, Sung Rok, KIM, Su Nam, KIM, Yongtae, KIM, Se Ryun
Принадлежит:

The present invention relates to two peptide nucleic acid (PNA) probe systems having a parallel binding structure for real-time amplification of nucleic acid, which can be nested-hybridized with a target nucleotide, a composition comprising the probe system, and a method for detection using same. By using the composition comprising the PNA probe system, according to the present invention, the existence of a nucleotide to be detected can be confirmed, the amount of the nucleotide can be decided at a fixed quantity, single nucleotide polymorphism (SNP), which is difficult to detect with existing technique, can be detected with high sensitivity, and simultaneous multiplexed detection of nucleotides of at least two types existing in a sample can be possible.

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Номер записи: 3
17-01-2013 дата публикации

NESTED HYBRIDIZATION PNA PROBE SYSTEM HAVING PARALLEL BINDING STRUCTURE

Номер: WO2013009070A2
Автор: KIM, Sung-Kee, PARK, Chwang Siek, JOE, Goon Ho, PARK, Heekyung, CHOI, Ji-Ah, CHOI, Sung Rok, KIM, Su Nam, KIM, Yongtae, KIM, Se Ryun
Принадлежит:

The present invention relates to two peptide nucleic acid (PNA) probe systems having a parallel binding structure for real-time amplification of nucleic acid, which can be nested-hybridized with a target nucleotide, a composition comprising the probe system, and a method for detection using same. By using the composition comprising the PNA probe system, according to the present invention, the existence of a nucleotide to be detected can be confirmed, the amount of the nucleotide can be decided at a fixed quantity, single nucleotide polymorphism (SNP), which is difficult to detect with existing technique, can be detected with high sensitivity, and simultaneous multiplexed detection of nucleotides of at least two types existing in a sample can be possible.

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Номер записи: 4
02-05-2016 дата публикации

NOVEL QUANTITATIVE ANALYSIS METHOD USING STANDARD QUANTIFICATION CONTROL PROBE INCLUDING REPORTER AND SMALL PHOTON

Номер: KR1020160047302A
Автор: KIM, SUNG KEE, KIM, KYUNG IL, JOE, GOON HO, CHOI, JAE JIN, WO, IN SEONG, KIM, SU NAM, YOON, JI HYE, PARK, JUN HO, LEE, SOE HYUN
Принадлежит:

The present invention relates to a quantitative analysis method of a target nucleic acid using a standard quantification control (SQC) probe including a reporter and a small photon, and more particularly to a quantitative analysis method relative to a fluorescent value of the SQC. The method of detecting and quantifying a target nucleic acid using SQC according to the present invention can inhibit amplification of a wild-type gene or undesired gene; effectively detect a specific gene sequence or various mutation due to deletion or insertion of a base, and single base mutation included in a sample through selective amplification and selective detection of a trace amount of a target gene to be detected; and simultaneously analyze an amplification curve and melting curve in real-time by using multiple detection probes and multiple amplification inhibition probes. Thus, the present invention can determine a genotype through analysis of a melting curve as well as target nucleic acid detection ...

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Номер записи: 5
15-11-2017 дата публикации

METHOD FOR DETERMINING BASE SEQUENCE IDENTITY USING PROBE AND MELTING PROFILE ANALYSIS

Номер: KR1020170125490A
Автор: PARK, JAE SIN, PARK, HEE KYUNG, JUNG, JIN WOOK, HUR, DEOK HWE, JEO, GOON HO
Принадлежит:

The present invention relates to a method for determining base sequence identity, base sequence modification and base sequence modification positions between samples by comparing melting patterns between a probe coupled with a reporter and a quencher, and a sample. According to the present invention, base sequence identity between samples with unknown base sequences can be confirmed in an easy manner. In the case of samples with known base sequences, base sequence modification can be rapidly and precisely determined and base sequence modification positions can be confirmed. COPYRIGHT KIPO 2017 ...

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Номер записи: 6
04-04-2017 дата публикации

METHOD FOR ANALYZING MELTING CURVE BY USING PNA PROBE FOR DIAGNOSING MICROSATELLITE INSTABILITY (MSI), METHOD FOR DIAGNOSING MSI BY USING SAME, AND KIT FOR DIAGNOSING MSI

Номер: KR1020170037095A
Автор: LEE, HAN WOO, YOO, MI JIN, HUR, DEOK HWE, PARK, HEE KYUNG, JOE, GOON HO
Принадлежит:

The present invention relates to a method for analyzing a melting curve by using a PNA probe for diagnosing microsatellite instability (MSI), a method for diagnosing MSI by using the same, and a kit for diagnosing MSI. More specifically, the present invention relates to a method for analyzing a melting curve according to the structure of a fluorescent PNA probe specifically bound according to the number of lost base mutations by using the fluorescent PNA probe capable of being specifically bound with a part in which identical bases are repeated; and a method for rapidly and accurately discriminating MSI by detecting the genetic mutation of a microsatellite marker generated by a loss of a base in a part in which identical bases are repeated and by analyzing the number of base mutations through the method for analyzing a melting curve. The present invention relates to a method and a kit for diagnosing MSI by analyzing the number of lost base mutations by analyzing a melting curve by using ...

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Номер записи: 7
17-01-2013 дата публикации

NESTED HYBRIDIZATION PNA PROBE SYSTEM HAVING PARALLEL BINDING STRUCTURE

Номер: WO2013009070A3
Автор: KIM, Sung-Kee, PARK, Chwang Siek, JOE, Goon Ho, PARK, Heekyung, CHOI, Ji-Ah, CHOI, Sung Rok, KIM, Su Nam, KIM, Yongtae, KIM, Se Ryun
Принадлежит:

The present invention relates to two peptide nucleic acid (PNA) probe systems having a parallel binding structure for real-time amplification of nucleic acid, which can be nested-hybridized with a target nucleotide, a composition comprising the probe system, and a method for detection using same. By using the composition comprising the PNA probe system, according to the present invention, the existence of a nucleotide to be detected can be confirmed, the amount of the nucleotide can be decided at a fixed quantity, single nucleotide polymorphism (SNP), which is difficult to detect with existing technique, can be detected with high sensitivity, and simultaneous multiplexed detection of nucleotides of at least two types existing in a sample can be possible.

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Номер записи: 8
21-02-2018 дата публикации

PEPTIDE NUCLEIC ACID COMPLEX HAVING IMPROVED CELL PERMEABILITY AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: KR1020180018405A
Автор: JEO, GOON HO, KIM, HYE JOO, YU, JI YEON, BATOCHIR CHINBAYAR, HUR, DEOK HWE, PARK, HEE KYUNG
Принадлежит:

The present invention relates to a novel structure of nucleic acid complex in which bioactive nucleic acid can be introduced into cells, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same and, more specifically, to a nucleic acid complex in which a bioactive nucleic acid is complementarily combined with a carrier peptide nucleic acid modified to have a positive charge overall, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same. COPYRIGHT KIPO 2018 ...

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Номер записи: 9
17-01-2013 дата публикации

COMPOSITION FOR SIMULTANEOUSLY DETECTING MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA BY MEANS OF REAL-TIME MULTIPLEX POLYMERASE CHAIN REACTION COMPRISING NESTED HYBRIDIZATION PNA PROBE SYSTEM HAVING PARALLEL BINDING STRUCTURE, AND METHOD FOR DETECTION USING SAME

Номер: WO2013009084A2
Автор: KIM, Sung-Kee, PARK, Chwang Siek, JOE, Goon Ho, PARK, Heekyung, KIM, Jihyun, CHOI, Ji-Ah, CHOI, Sung Rok, KIM, Su Nam, KIM, Yongtae, KIM, Se Ryun, JANG, Hyunjung
Принадлежит:

The present invention relates to a composition for simultaneously detecting Mycobacterium tuberculosis and nontuberculous mycobacteria based on a nested hybridization peptide nucleic acid (PNA) probe system having a parallel binding structure, and to a method for simultaneously detecting Mycobacterium tuberculosis and nontuberculous mycobacteria using the composition and real-time polymerase chain reaction. Also, the present invention relates to a primer, a probe composition, and a method for analyzing to simultaneously detect Mycobacterium tuberculosis and nontuberculous mycobacteria based on the nested hybridization PNA probe system having the parallel binding structure. When carrying out the real-time multiplexed polymerase chain reaction by using the composition comprising the nested hybridized PNA probe system having the parallel binding structure, according to the present invention, Mycobacterium tuberculosis and nontuberculous mycobacteria can be simultaneously and accurately detected ...

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Номер записи: 10
15-02-2018 дата публикации

PEPTIDE NUCLEIC ACID COMPLEX HAVING IMPROVED CELL PERMEABILITY AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: WO2018030789A1
Автор: JEO, Goonho, KIM, Hye Joo, YU, Ji-Yeon, BATOCHIR, Chinbayar, HUR, Deokhwe, PARK, Hee Kyung
Принадлежит:

The present invention relates to a novel structure of nucleic acid complex in which bioactive nucleic acid can be introduced into cells, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same and, more specifically, to a nucleic acid complex in which a bioactive nucleic acid is complementarily combined with a carrier peptide nucleic acid modified to have a positive charge overall, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same.

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Номер записи: 11
17-01-2013 дата публикации

COMPOSITION FOR SIMULTANEOUSLY DETECTING MYCOBACTERIUM TUBERCULOSIS AND NONTUBERCULOUS MYCOBACTERIA BY MEANS OF REAL-TIME MULTIPLEX POLYMERASE CHAIN REACTION COMPRISING NESTED HYBRIDIZATION PNA PROBE SYSTEM HAVING PARALLEL BINDING STRUCTURE, AND METHOD FOR DETECTION USING SAME

Номер: WO2013009084A3
Автор: KIM, Sung-Kee, PARK, Chwang Siek, JOE, Goon Ho, PARK, Heekyung, KIM, Jihyun, CHOI, Ji-Ah, CHOI, Sung Rok, KIM, Su Nam, KIM, Yongtae, KIM, Se Ryun, JANG, Hyunjung
Принадлежит:

The present invention relates to a composition for simultaneously detecting Mycobacterium tuberculosis and nontuberculous mycobacteria based on a nested hybridization peptide nucleic acid (PNA) probe system having a parallel binding structure, and to a method for simultaneously detecting Mycobacterium tuberculosis and nontuberculous mycobacteria using the composition and real-time polymerase chain reaction. Also, the present invention relates to a primer, a probe composition, and a method for analyzing to simultaneously detect Mycobacterium tuberculosis and nontuberculous mycobacteria based on the nested hybridization PNA probe system having the parallel binding structure. When carrying out the real-time multiplexed polymerase chain reaction by using the composition comprising the nested hybridized PNA probe system having the parallel binding structure, according to the present invention, Mycobacterium tuberculosis and nontuberculous mycobacteria can be simultaneously and accurately detected ...

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Номер записи: 12
13-09-2018 дата публикации

프로브 및 융해패턴 분석을 이용한 염기서열 동일성 판별방법

Номер: KR0101898258B1
Автор: 박재신, 박희경, 정진욱, 허덕회, 조군호
Принадлежит: 주식회사 시선바이오머티리얼스

... 본 발명은 리포터(reporter) 및 소광자(quencher)가 결합된 프로브와 시료와의 융해패턴을 비교하여 시료 간의 염기서열 동일성, 염기서열 변이 여부 및 염기서열 변이 위치를 판별하는 방법에 관한 것으로, 본 발명을 이용하면 염기서열을 알지 못하는 시료 간의 염기서열 일치 여부를 용이하게 확인 가능하고, 염기서열을 알고 있는 시료의 경우 염기서열 변이 여부를 신속하고 정확하게 판별할 수 있으며, 염기서열 변이 위치까지 확인할 수 있는 장점이 있다.

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Номер записи: 13
05-04-2016 дата публикации

PRIMER ENHANCING REACTIVITY OF PROBE MIXTURE AND USE THEREOF

Номер: KR1020160036906A
Автор: KIM, SUNG KEE, JOE, GOON HO, WO, IN SEONG, CHOI, JAE JIN, PARK, JUN HO, YOON, JI HYE
Принадлежит:

The present invention relates to a method of sensitively detecting target nucleic acid using a clamping probe and detection probe mixture and various primers, which is a method of improving specificity of PCR efficiency and detection sensitivity using various primers; and a method of detecting target nucleic acid better than conventional methods by using available primers by using a detection probe for detecting target nucleic acid in real time, mixed with a clamping probe mixture for inhibiting the amplification of a wild type gene or an undesired gene. According to the present invention, using a target nucleic acid detection method through various primers and probe mixtures, the amplification of a wild type gene or an undesired gene can be suppressed. In addition, through selective amplification and selective detection of a trace amount of a target gene to be detected, a single nucleotide mutation included in a sample and various mutations caused by deficiency or insertion of a base, ...

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Номер записи: 14
21-02-2018 дата публикации

클램핑 프로브 및 검출 프로브를 이용한 다중 표적핵산 검출방법

Номер: KR0101830700B1
Автор: 조군호, 김용태, 김성기, 김진우, 최재진, 오인성, 윤지혜, 김수남, 박준호
Принадлежит: 주식회사 파나진

... 본 발명은 클램핑 프로브 및 검출 프로브를 이용한 표적핵산 검출방법에 관한 것으로, 더욱 자세하게는 표적핵산을 실시간으로 검출하기 위한 하나 이상의 검출 프로브(detection probe) 및 야생형 유전자 또는 원하지 않는 유전자의 증폭을 억제하는 클램핑 프로브(clamping probe)를 포함하는 프로브 혼합체를 이용하여 동시에 다중 표적핵산을 검출하는 방법 및 이를 이용한 키트에 관한 것이다. 본 발명에 따른 프로브 혼합체를 통한 표적핵산 검출방법을 이용하면 야생형 유전자 또는 원하지 않는 유전자 증폭의 억제가 가능하고 검출하고자 하는 극미량의 표적 유전자의 선택적 증폭과 선택적 검출을 통해 시료 속에 포함된 단일염기변이 및 염기의 결손 또는 삽입에 의한 다양한 변이, 또는 특정 유전자 서열을 효과적으로 검출할 수 있으며, 다중의 검출 프로브와 다중의 증폭 억제 프로브를 사용하여 실시간 증폭곡선과 융해곡선의 동시 분석이 가능해 동시 다중적으로 표적핵산 검출 및 정량뿐 아니라 융해곡선분석을 통한 유전형판별이 가능하다. 본 발명에 따르는 프로브 혼합체는 원하지 않는 유전자가 과량 혼합되어 있는 시료에서 원하는 표적핵산만을 높은 민감도로 (0.01%) 검출이 가능하여, 조기진단 및 극소량의 돌연변이를 검출이 가능하다.

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Номер записи: 15