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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 11. Отображено 11.
23-11-2016 дата публикации

SCREENING METHOD OF GENOTYPE IN ANTIBODY Fc GAMMA RECEPTOR(FCGR) INVOLVED IN ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY (ADCC) USING PEPTIDE NUCLEIC ACIDS

Номер: KR1020160134094A
Автор: HUR, DEOK HWE, YOO, MI JIN, PARK, HEE KYUNG, JUNG, JIN WOOK
Принадлежит:

The present invention relates to a screening method of a genotype in an antibody Fc gamma receptor involved in antibody-dependent cell-mediated cytotoxicity (ADCC) used as an antibody therapeutic agent and, more specifically, to a blocker-peptide nucleic acid probe, a fluorescent peptide nucleic acid probe, and a pair of primers for screening a genotype of FCGR2A or FCGR3A genes, and to a screening method of a genotype of FCGR2A or FCGR3A in an antibody Fc gamma receptor using the same. COPYRIGHT KIPO 2016 ...

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Номер записи: 1
15-11-2017 дата публикации

METHOD FOR DETERMINING BASE SEQUENCE IDENTITY USING PROBE AND MELTING PROFILE ANALYSIS

Номер: KR1020170125490A
Автор: PARK, JAE SIN, PARK, HEE KYUNG, JUNG, JIN WOOK, HUR, DEOK HWE, JEO, GOON HO
Принадлежит:

The present invention relates to a method for determining base sequence identity, base sequence modification and base sequence modification positions between samples by comparing melting patterns between a probe coupled with a reporter and a quencher, and a sample. According to the present invention, base sequence identity between samples with unknown base sequences can be confirmed in an easy manner. In the case of samples with known base sequences, base sequence modification can be rapidly and precisely determined and base sequence modification positions can be confirmed. COPYRIGHT KIPO 2017 ...

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Номер записи: 2
04-04-2017 дата публикации

METHOD FOR ANALYZING MELTING CURVE BY USING PNA PROBE FOR DIAGNOSING MICROSATELLITE INSTABILITY (MSI), METHOD FOR DIAGNOSING MSI BY USING SAME, AND KIT FOR DIAGNOSING MSI

Номер: KR1020170037095A
Автор: LEE, HAN WOO, YOO, MI JIN, HUR, DEOK HWE, PARK, HEE KYUNG, JOE, GOON HO
Принадлежит:

The present invention relates to a method for analyzing a melting curve by using a PNA probe for diagnosing microsatellite instability (MSI), a method for diagnosing MSI by using the same, and a kit for diagnosing MSI. More specifically, the present invention relates to a method for analyzing a melting curve according to the structure of a fluorescent PNA probe specifically bound according to the number of lost base mutations by using the fluorescent PNA probe capable of being specifically bound with a part in which identical bases are repeated; and a method for rapidly and accurately discriminating MSI by detecting the genetic mutation of a microsatellite marker generated by a loss of a base in a part in which identical bases are repeated and by analyzing the number of base mutations through the method for analyzing a melting curve. The present invention relates to a method and a kit for diagnosing MSI by analyzing the number of lost base mutations by analyzing a melting curve by using ...

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Номер записи: 3
27-09-2018 дата публикации

METHOD FOR MELTING CURVES ANALYSIS USING BIFUNCTIONAL PNA PROBE, AND METHOD FOR DIAGNOSING MICROSATELLITE INSTABILITY AND KIT FOR DIAGNOSING MICROSATELLITE INSTABILITY USING SAME

Номер: WO2018174318A1
Автор: LEE, Han Woo, LEE, Si Seok, HUR, Deokhwe, PARK, Hee Kyung
Принадлежит:

The present invention relates to a method for melting curve analysis using a bifunctional PNA probe, and a method for diagnosing microsatellite instability and a kit for diagnosing microsatellite instability using the same. More specifically, the present invention relates to: a method for melting curve analysis according to the structure of a fluorescent PNA probe bound with different bonding strengths according to the number of deleted base mutations by using a fluorescent PNA probe capable of being specifically bound to a region in which the same bases are repeated; and a diagnosis method capable of rapidly and accurately determining microsatellite instability by detecting a gene mutation in a microsatellite marker generated by a base deletion in a region, in which the same bases are repeated, by said analysis method and by analyzing the number of base mutations that occur as a result. According to the present invention, it is possible to analyze whether a microsatellite marker gene has ...

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Номер записи: 4
21-02-2018 дата публикации

PEPTIDE NUCLEIC ACID COMPLEX HAVING IMPROVED CELL PERMEABILITY AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: KR1020180018405A
Автор: JEO, GOON HO, KIM, HYE JOO, YU, JI YEON, BATOCHIR CHINBAYAR, HUR, DEOK HWE, PARK, HEE KYUNG
Принадлежит:

The present invention relates to a novel structure of nucleic acid complex in which bioactive nucleic acid can be introduced into cells, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same and, more specifically, to a nucleic acid complex in which a bioactive nucleic acid is complementarily combined with a carrier peptide nucleic acid modified to have a positive charge overall, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same. COPYRIGHT KIPO 2018 ...

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Номер записи: 5
20-11-2015 дата публикации

MANUFACTURING METHOD OF METAGENOMIC LIBRARY BY INHIBITING AMPLIFICATION OF TARGET MICROBIAL SPECIES USING PNA PROBE

Номер: KR1020150129554A
Автор: SONG, MIN SIK, PARK, HEE KYUNG, HUR, DEOK HWE, PARK, JAE SIN, CHAE, SUHN KEE
Принадлежит:

The present invention relates to a peptide nucleic acid (PNA) set for suppressing an amplification of a dominant microbial species, and a manufacturing method of a metagenomic library using the same. More specifically, one or more PNA probes including a unique base sequence of top three microbial species gained through a general metagenomic analysis are added into a manufacture of a library, and a manufacturing condition is changed, in order to suppress the amplification of a target microbial species. By reducing a rate which the dominant microbial species occupies using a PNA probe having an excellent binding force with a DNA, a discovery of a new microbial species and the metagenomic analysis can be simply and exactly distinguished. COPYRIGHT KIPO 2016 ...

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Номер записи: 6
19-07-2016 дата публикации

DEVICE FOR FILTERING MICROORGANISMS AND MICRO-PARTICLES INCLUDING ARTIFICIALLY SYNTHESIZED NUCLEIC ACID ANALOG APTAMER, AND FILTERING METHOD USING SAME

Номер: KR1020160086057A
Автор: HUR, DEOK HWE, BATOCHIR CHINBAYAR, YOO, MI JIN, PARK, HEE KYUNG, JUNG, JIN WOOK
Принадлежит:

The present invention relates to a device for filtering microorganisms and micro-particles including an artificially synthesized nucleic acid analog aptamer, and a filtering method using the same. More specifically, the present invention relates to a filtering device capable of removing proteins, antibiotics, bacteria, and viruses which are contaminants contained in a target solution by using a filter or a magnetic material solid containing a peptide nucleic acid aptamer, and to filtering method using the same. When a solid containing a nucleic acid analog aptamer according to the present invention is used, a contaminant of a target solution can be effectively removed, and the solid can be generally applied to a purification means capable of replacing a function of a filter and capable of filtering an organic compound or an organic material such as antibiotics, proteins, bacteria, and viruses. Furthermore, according to the present invention, a nucleic acid analog aptamer which can be bound ...

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Номер записи: 7
15-02-2018 дата публикации

PEPTIDE NUCLEIC ACID COMPLEX HAVING IMPROVED CELL PERMEABILITY AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: WO2018030789A1
Автор: JEO, Goonho, KIM, Hye Joo, YU, Ji-Yeon, BATOCHIR, Chinbayar, HUR, Deokhwe, PARK, Hee Kyung
Принадлежит:

The present invention relates to a novel structure of nucleic acid complex in which bioactive nucleic acid can be introduced into cells, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same and, more specifically, to a nucleic acid complex in which a bioactive nucleic acid is complementarily combined with a carrier peptide nucleic acid modified to have a positive charge overall, to a composition comprising the nucleic acid complex for treatment and diagnosis of diseases, and to a method for regulating the expression of a target gene using the same.

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Номер записи: 8
19-10-2018 дата публикации

FUEL HEATING DEVICE FOR SHIP

Номер: KR101909192B1
Автор: HEO DOUG HOI
Принадлежит: DH ENGINEERING & TECHNOLOGY CO., LTD.

Provided is a fuel heating device for a ship capable of maintaining temperature of fuel and lowering viscosity. The fuel heating device for a ship comprises: a housing having a rectangular structure in which an upper plate, a bottom plate, a left plate, a right plate, a front plate and a rear plate are formed and mounted inside an oil tank in which heavy fuel oil is stored, wherein the housing includes a vapor inflow pipe formed on the left plate to introduce vapor supplied from the outside and a vapor outflow pipe formed on the right plate to discharge the introduced vapor to the outside; guide plates arranged inside the housing in zigzags by turns to be spaced from each other in a back and forth direction inside the housing so that the inside of the housing is divided into several receiving spaces; a plurality of oil passage pipes arranged side by side to penetrate the housing in a vertical direction, wherein an upper end is combined with the upper plate and a lower end is combined with ...

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Номер записи: 9
06-04-2016 дата публикации

Method of preparing metagenomic library by inhibiting amplification of target microbial species using PNA probe

Номер: KR0101609295B1
Автор: 송민식, 박희경, 허덕회, 박재신, 채순기
Принадлежит: 주식회사 시선바이오머티리얼스, 배재대학교 산학협력단

... 본 발명은 우점하는 미생물 종의 증폭을 억제하기 위한 펩티드 핵산(PNA) 세트 및 이를 이용한 메타지놈 라이브러리 제작 방법에 관한 것으로, 더욱 구체적으로는 일반적인 메타지놈 분석을 통해 얻어진 상위 3개 미생물 종의 고유한 염기서열을 포함하여 이루어진 하나 이상의 PNA 프로브를 라이브러리 제작에 첨가하고 제작 조건을 변화시켜 표적 미생물 종의 증폭을 억제하는 것이 특징이다. 본 발명은 DNA와의 결합력이 우수한 PNA 프로브를 이용하여 우점하는 미생물 종이 차지하는 비율을 줄여줌으로써, 새로운 미생물 종의 발견과 메타지놈 분석을 간편하고 정확하게 판별할 수 있는 효과가 있다.

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Номер записи: 10
13-09-2018 дата публикации

프로브 및 융해패턴 분석을 이용한 염기서열 동일성 판별방법

Номер: KR0101898258B1
Автор: 박재신, 박희경, 정진욱, 허덕회, 조군호
Принадлежит: 주식회사 시선바이오머티리얼스

... 본 발명은 리포터(reporter) 및 소광자(quencher)가 결합된 프로브와 시료와의 융해패턴을 비교하여 시료 간의 염기서열 동일성, 염기서열 변이 여부 및 염기서열 변이 위치를 판별하는 방법에 관한 것으로, 본 발명을 이용하면 염기서열을 알지 못하는 시료 간의 염기서열 일치 여부를 용이하게 확인 가능하고, 염기서열을 알고 있는 시료의 경우 염기서열 변이 여부를 신속하고 정확하게 판별할 수 있으며, 염기서열 변이 위치까지 확인할 수 있는 장점이 있다.

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Номер записи: 11