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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 33. Отображено 33.
19-04-2012 дата публикации

AZETIDINIUM SALT AS FP-CIT PRECURSOR, METHOD FOR SELECTIVELY PREPARING SAME, AND FP-CIT SYNTHESIS

Номер: KR2012050315A2
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, PARK, Sang-Don, CHI, Hyung-Min, SUNG, Hyun-Ju
Принадлежит:

The present invention relates to an azetidinium salt of an N-(3-sufonyloxypropyl)-2-β-carbomethoxy-3-β-(4-iodophenyl)trophan compound, a selective method for preparing same and application thereof, and more particularly, provides a method for selectively preparing the azetidinium salt of the N-(3-sufonyloxypropyl)-2-β-carbomethoxy-3-β-(4-iodophenyl)trophan compound by dissolving the N-(3-sufonyloxypropyl)-2-β-carbomethoxy-3-β-(4-iodophenyl)trophan compound in a polar solvent and then heating same.

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Номер записи: 1
24-01-2017 дата публикации

INTERNAL CIRCULATION REACTION CONTAINER OF CASSETTE FOR PREPARING RADIOPHARMACEUTICALS AND METHOD THEREOF

Номер: KR1020170008463A
Автор: CHI, DAE YOON, PARK, CHAN SOO, LEE, KYO CHUL, KIL, HEE SEUP
Принадлежит:

The present invention relates to a reaction container of a preparing machine for radiopharmaceuticals and a method for reacting the radiopharmaceuticals using the same. The present invention prevents a labeling solution in the reaction container from being refluxed and decreases generation of bubbles when preparing the radiopharmaceuticals used for a diagnostic imaging and others. The present invention provides the reaction container of which lines connected to the reaction container communicate with each other, thereby forming a circulation channel, and also provides the method using the same. Therefore, the reflux is not caused and a reaction yield of the reaction between the radiopharmaceuticals and a precursor reaction solution is increased even when a positive pressure is generated in the reaction container during the labeling process. COPYRIGHT KIPO 2017 ...

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Номер записи: 2
03-05-2018 дата публикации

COMPOUND FOR POSITRON EMISSION TOMOGRAPHY IMAGE OF ATHEROSCLEROTIC ARTERIAL PLAQUE, AND METHOD FOR PRODUCING SAME

Номер: WO2018079882A1
Автор: CHI, Dae Yoon, LEE, Byoung Se, CHU, So Young, CHANG, Kiyuk, O, Joo Hyun, PARK, Hyo Eun
Принадлежит:

The present invention relates to a compound marked with a radioactive isotope used for positron emission tomography (PET) for imaging atherosclerotic arterial plaque, which is a cause of cardio-cerebrovascular diseases; and a production method and an application thereof. More specifically, the present invention relates to a compound, a method for producing the same, and a method for imaging atherosclerotic arterial plaque by using the same, wherein the compound is marked by a radioactive isotope and coupled with 2 to 4 peptides capable of selectively targeting atherosclerotic arterial plaque, and thus an excellent PET image of atherosclerotic plaque in an artery that has a fast flow of blood can be obtained in a short amount of time using a small amount of the compound.

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Номер записи: 3
12-06-2017 дата публикации

방사성 의약품 제조 카세트의 내부 순환 반응용기 및 그를 이용한 방사성 의약품 제조방법

Номер: KR0101745879B1
Автор: 지대윤, 박찬수, 이교철, 길희섭
Принадлежит: 서강대학교산학협력단

... 본 발명은 영상진단 등에 이용되는 방사성 의약품을 제조하는 과정에서 반응용기내의 표지용액이 역류하지 않게 하고, 버블의 발생을 줄이기 위한 방사성의약품 제조장치의 반응용기 및 이를 이용하여 방사성 시약을 반응시키는 방법에 관한 것으로서, 표지화 과정에서 반응용기 내에 양압이 발생한다 하더라도 반응용기에 연결된 라인들이 연통되어 순환유로를 이루어 역류가 발생하지 않고 방사성시약과, 전구체 반응용액이 반응 수율이 높아질 수 있는 반응용기 및 방법을 제공한다.

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Номер записи: 4
28-11-2013 дата публикации

METHOD FOR SYNTHESIZING RADIOPHARMACEUTICALS USING A CARTRIDGE

Номер: WO2013176522A1
Автор: CHI, Dae Yoon, LEE, Byoung Se, LEE, Jae Hak, CHU, So Young, JUNG, Woon Jung
Принадлежит:

The present invention relates to a method for synthesizing a radiopharmaceutical using a cartridge, which makes it possible to carry out several steps of reaction required for synthesizing a radiopharmaceutical in the cartridge filled with a polymer. A method for synthesizing a radiopharmaceutical according to the present invention enables each step's reaction to be carried out with the solution confined in the cartridge so as not to flow out, thus being simplified compared to the conventional methods for synthesizing radiopharmaceuticals, and expediting the synthesis.

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Номер записи: 5
06-02-2018 дата публикации

RADIOISOTOPE LABELED COMPOUNDS FOR DIAGNOSIS OF TUMOR AND PRECURSOR COMPOUNDS

Номер: KR101824412B1
Автор: CHI, DAE YOON, LEE, BYOUNG SE, CHU, SO YOUNG, JEONG, HYEON JIN, MOON, HEE JUNG, LEE, KYO CHUL, LEE, YONG JIN, PARK, JI AE, KIM, KWNAG IL
Принадлежит: FUTURECHEM CO., LTD.

The present invention relates to radioisotope labeled compounds for diagnosis of tumor and to precursor compounds, and more particularly, to radioisotope labeled compounds for diagnosis of tumor, which can obtain more tumor-specific positron emission tomography (PET) images with no intake of inflammatory tissues, and to precursor compounds. The radioisotope labeled compounds according to the present invention, as tyrosine derivatives, intake no inflammatory tissues so that tumor-specific PET images can be obtained. More specifically, the labeling compound according to the present invention has superior in-vivo pharmacokinetic properties to obtain a clear tumor image, and thus can be used as a PET radiopharmaceutical for diagnosis of a tumor. COPYRIGHT KIPO 2018 ...

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Номер записи: 6
27-12-2018 дата публикации

18F-LABELLED COMPOUND FOR PROSTATE CANCER DIAGNOSIS, AND USE THEREOF

Номер: WO2018236115A1
Автор: CHI, Dae Yoon, LEE, Byoung Se, CHU, So Young, KIM, Min Hwan, JUNG, Woon Jung, MOON, Hee Jung, JEONG, Hyeon Jin, YANG, Sung Uk, LEE, Kyo Chul, LEE, Yong Jin, PARK, Ji Ae, KIM, Mi Hyun, YOO, Ran Ji, LIM, Sang Moo
Принадлежит:

The present invention relates to an 18F-labelled compound, and a use thereof. The compound selectively binds to a prostate-specific membrane antigen (PSMA), and enables the acquisition of clear prostate cancer images in a short time when used in positron emission tomography (PET).

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Номер записи: 7
03-10-2019 дата публикации

PSMA-TARGETED RADIOPHARMACEUTICAL FOR DIAGNOSING AND TREATING PROSTATE CANCER

Номер: WO2019190266A1
Автор: CHI, Dae Yoon, LEE, Byoung Se, CHU, So Young, JUNG, Woon Jung, JEONG, Hyeon Jin, MOON, Hee Jung, KIM, Hyeon Seok, KIM, Min Hwan, KIM, Mi Hyun, KIM, Jae Seong, LEE, Kyo Chul, LEE, Yong Jin
Принадлежит:

The present invention relates to a pharmaceutical composition for diagnosing and treating prostate cancer, capable of targeting PSMA, and a compound provided by one aspect of the present invention has a glutamine-urea-lysine compound to which a radioactive metal-coupled chelator is structurally coupled and to which an aryl group that can additionally bind to PSMA protein is coupled.Coupling between the glutamine-urea-lysine compound and the chelator includes a polar spacer so as to serve the role of reducing in vivo nonspecific coupling and exhibit an effect of being rapidly removed from vital organs, but not from prostate cancer. These characteristics lower the radiation exposure, which is caused by a therapeutic radioisotope-coupled compound, to normal tissue and organs, and thus reduce side effects. In addition, a compound that contains a phenyl group having a coupling force with albumin has an increased residence time in the blood, thereby becoming more accumulated in prostate cancer ...

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Номер записи: 8
28-12-2018 дата публикации

18F-LABELED COMPOUND FOR DIAGNOSING PROSTATE CANCER AND USES THEREOF

Номер: KR1020180138169A
Автор: CHI DAE YOON, LEE BYOUNG SE, CHU SO YOUNG, KIM, MIN HWAN, JUNG, WOON JUNG, MOON, HEE JUNG, JEONG, HYEON JIN, YANG, SUNG UK, LEE, KYO CHUL, LEE, YONG JIN, PARK, JI AE, KIM, MI HYUN, YOO, RAN JI, LIM, SANG MOO
Принадлежит:

The present invention relates to an 18F-labeled compound and uses thereof. The above compound has a characteristic of being selectively bound to a prostate-specific membrane antigen (PSMA), and can be used in positron emission tomography (PET) to obtain a prostate cancer image in a short time. COPYRIGHT KIPO 2019 (AA) Example 7-3 (BB) Example 7-6 (CC) Comparative example 1 ...

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Номер записи: 9
28-03-2018 дата публикации

MANUFACTURING METHOD OF FLUORINATED COMPOUND USING ALCOHOL SOLVENT HAVING CARBONYL GROUP

Номер: KR101842989B1
Автор: CHI DAE YOON, LEE BYOUNG SE, JEONG HYEON JIN, YANG SUNG UK
Принадлежит: FUTURECHEM CO., LTD.

The present invention relates to a method for manufacturing an organic fluoro-compound including fluorine ((^18)F) which uses a solvent in a nucleophilic fluorinated reaction wherein the solvent is expressed by chemical formula 1 so as to manufacture an organic fluoro-compound at high yield. The solvent has very excellent solubility with respect to a precursor compound to have a merit suitable for automatic combination of (^18)F-labelled radiopharmaceutical. COPYRIGHT KIPO 2018 ...

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Номер записи: 10
04-03-2010 дата публикации

NANOPARTICLE SENSOR FOR MEASURING PROTEASE ACTIVITY AND METHOD FOR MANUFACTURING THE SAME

Номер: KR2010024609A2
Автор: KWON, Ick-Chan, CHOI, Kui-Won, KIM, Kwang-Meyung, YOUN, In-Chan, LEE, Seul-Ki, PARK, Kyeong-Soon, MOON, Dae-Hyuk, CHI, Dae-Yoon, LEE, Seung-Jin, MYUNG, Seung-Jae
Принадлежит:

The present invention relates to a nanoparticle sensor for measuring protease activity for protease imaging and a method for manufacturing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis, and dementia ...

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Номер записи: 11
12-11-2015 дата публикации

CELL PRODUCING MUTANT OF TARGET PROTEIN, PREPARING METHOD THEREOF, AND PRODUCING METHOD OF MUTANT OF TARGET PROTEIN USING THE CELL

Номер: KR0101568336B1
Автор: 이현수, 지대윤, 이상열
Принадлежит: 서강대학교산학협력단

... 본원은, 목적 단백질의 돌연변이체를 생성하는 세포, 그 제조 방법, 및 목적 단백질의 돌연변이체의 제조 방법에 관한 것이다.

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Номер записи: 12
23-12-2015 дата публикации

PREPARING METHOD FOR RADIO-PHARMACEUTICAL PRODUCT BY USING GUANIDINE-BONDED POLYMER

Номер: KR1020150142869A
Автор: CHI, DAE YOON, LEE, BYOUNG SE, LEE, JAE HAK, PARK, CHAN SOO, CHU, SO YOUNG, JUNG, WOON JUNG
Принадлежит:

The present invention relates to a preparing method for a radio-pharmaceutical product by using guanidine-bonded polymer and, more specifically, relates to a production of a high-yield radio-pharmaceutical product inside a cartridge or a column in a short production time in a simple way. By using the preparing method of the present invention, a radioactive isotope can be easily captured by flowing radioactive solution into the cartridge or the column. Due to the basicity of a guanidine functional group, reaction labeling a radioactive isotope on a precursor compound can be easily performed inside the cartridge or the column. In addition, additional deprotecting reaction can be easily performed inside the cartridge or the column by inserting acidic or basic solution into the cartridge or the column. In particular, F-18 labeling reaction is conducted in a solution phase without an additional catalyst for phase transition. Therefore, manufacturing costs for the radio-pharmaceutical product ...

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Номер записи: 13
15-03-2012 дата публикации

SULPHONATE PRECURSOR HAVING A 1,2,3-TRIAZOLIUM SALT, A PRODUCTION METHOD THEREFOR AND AN INTRAMOLECULAR NUCLEOPHILIC FLUORINATION REACTION USING THE SAME

Номер: KR2012033374A2
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, CHU, So-Young, LEE, Jae-Hak, KWON, Hye-Rim
Принадлежит:

The present invention relates to a sulphonate precursor having a 1,2,3-triazolium salt, and to a production method and use therefor, and more specifically exhibits the advantages that the reaction rate can be increased by introducing an organic salt having a phase-transfer catalyst effect into the leaving group of the precursor and thereby inducing an intramolecular nucleophilic substitution reaction of the nucleophile and sulphonate precursor, and use of a separate phase-transfer catalyst is avoided. The invention can be used as a sulphonate precursor for the effective production of an [18F]radiopharmaceutical used in positron emission tomography.

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Номер записи: 14
22-11-2012 дата публикации

PRÉCURSEUR MARQUÉ AU18-F POUR SUBSTANCES RADIOACTIVES À USAGE MÉDICAL UTILISÉES EN TOMOGRAPHIE PAR ÉMISSION DE POSITONS ET SON PROCÉDÉ DE PRÉPARATION

Номер: WO2012157900A2
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, PARK, Chansoo, LEE, Min-Hyung, CHA, Hyojin, CHO, Woojin, KANG, Heewon, KIM, Kyunghun
Принадлежит:

The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing18F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of compounds after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.

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Номер записи: 15
21-12-2015 дата публикации

SULFONATE COMPOUND HAVING ORGANIC SALTS, ORGANIC FLUORO COMPOUND HAVING ORGANIC SALTS PRODUCED BY USING SAME, AND METHOD FOR PRODUCING SAME

Номер: KR1020150141816A
Автор: CHI, DAE YOON, LEE, BYOUNG SE, AHN, HYE JIN, KANG, BYUNG SOO, UTHAIWAN SIRION, CHU, SO YOUNG
Принадлежит:

The present invention relates to a sulfonate compound having organic salts, an organic fluoro compound having organic salts produced by using the same, and a method for producing the same. More particularly, the present invention relates to: an organic fluoro compound having organic salts which is used to manufacture an 18F-labeled or 19F-labeled radiopharmaceutical product for positron emission tomography (PET); an organic fluoro compound having organic salts produced by using the same; and a method for producing the same. According to the present invention, the sulfonate compound having organic salts and the organic fluoro compound are easily dissolved in a polar solvent such as an aqueous solution due to organic salts in the compound and thus enables conjugation reaction with a polar compound which is, for example, a biocompound such as peptides, protein, glucose, and nucleotides to be performed in an easy manner. COPYRIGHT KIPO 2016 (AA) Lyophilic fluorination reaction (BB) Conversion ...

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Номер записи: 16
25-07-2013 дата публикации

FINE COLUMN TUBE FOR CHROMATOGRAPHY FOR SEPARATION AND DETECTION OR QUANTITATIVE ANALYSIS OF RADIOACTIVE MATERIAL AND METHOD FOR DETECTING RADIOACTIVE MATERIAL USING THE FINE COLUMN TUBE

Номер: WO2013109069A1
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, LEE, Jae-Hak, CHU, So-Young, JUNG, Woon-Jung
Принадлежит:

The present invention relates to a fine column tube for chromatography used in a radioisotope labeling reaction and in managing the quality of a radioisotope labeled material. The present invention also relates to a method for detecting a radioactive material using the fine column tube. The fine column tube of the present invention enables the deployment and analysis of a radioactive material to be quickly performed, and prevents a radioactive material from volatilizing into the air even when the radioactive material is volatile, thus enabling the amount of the radioactive material to be accurately measured.

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Номер записи: 17
15-03-2012 дата публикации

SULPHONATE PRECURSOR HAVING A 1,2,3-TRIAZOLIUM SALT, A PRODUCTION METHOD THEREFOR AND AN INTRAMOLECULAR NUCLEOPHILIC FLUORINATION REACTION USING THE SAME

Номер: WO2012033374A3
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, CHU, So-Young, LEE, Jae-Hak, KWON, Hye-Rim
Принадлежит:

The present invention relates to a sulphonate precursor having a 1,2,3-triazolium salt, and to a production method and use therefor, and more specifically exhibits the advantages that the reaction rate can be increased by introducing an organic salt having a phase-transfer catalyst effect into the leaving group of the precursor and thereby inducing an intramolecular nucleophilic substitution reaction of the nucleophile and sulphonate precursor, and use of a separate phase-transfer catalyst is avoided. The invention can be used as a sulphonate precursor for the effective production of an [18F]radiopharmaceutical used in positron emission tomography.

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Номер записи: 18
22-11-2012 дата публикации

PRÉCURSEUR MARQUÉ AU18-F POUR SUBSTANCES RADIOACTIVES À USAGE MÉDICAL UTILISÉES EN TOMOGRAPHIE PAR ÉMISSION DE POSITONS ET SON PROCÉDÉ DE PRÉPARATION

Номер: WO2012157900A3
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, PARK, Chansoo, LEE, Min-Hyung, CHA, Hyojin, CHO, Woojin, KANG, Heewon, KIM, Kyunghun
Принадлежит:

The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing18F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of compounds after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.

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Номер записи: 19
05-05-2011 дата публикации

(3-FLUORO-2-HYDROXY)PROPYL-FUNCTIONALIZED ARYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENTS FOR THE DIAGNOSIS OR TREATMENT OF NEURODEGENERATIVE BRAIN DISEASES

Номер: KR2011052888A2
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, UTHAIWAN, Sirion, CHU, So-Young, BAE, Yu-Jin, PARK, Chansoo, MOON, Dae-Hyuk, RYU, Jin-Sook, KIM, Jae-Seung, OH, Seung-Jun
Принадлежит:

The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to β-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease. Further, the aryl derivatives of the present invention bind to low molecular β-amyloid peptide conjugates to inhibit the generation of malignant high molecular β-amyloid plaque ...

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Номер записи: 20
19-04-2012 дата публикации

AZETIDINIUM SALT AS FP-CIT PRECURSOR, METHOD FOR SELECTIVELY PREPARING SAME, AND FP-CIT SYNTHESIS

Номер: WO2012050315A3
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, PARK, Sang-Don, CHI, Hyung-Min, SUNG, Hyun-Ju
Принадлежит:

The present invention relates to an azetidinium salt of an N-(3-sufonyloxypropyl)-2-β-carbomethoxy-3-β-(4-iodophenyl)trophan compound, a selective method for preparing same and application thereof, and more particularly, provides a method for selectively preparing the azetidinium salt of the N-(3-sufonyloxypropyl)-2-β-carbomethoxy-3-β-(4-iodophenyl)trophan compound by dissolving the N-(3-sufonyloxypropyl)-2-β-carbomethoxy-3-β-(4-iodophenyl)trophan compound in a polar solvent and then heating same.

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Номер записи: 21
03-12-2015 дата публикации

방사선 또는 자외선 조사에 의해 활성화되는 항암제 전구체 및 이의 용도

Номер: KR1020150135796A
Автор: 류주희, 김광명, 권익찬, 최귀원, 김상윤, 이범석, 지대윤, 길희섭, 성현주
Принадлежит:

... 본 발명은 아세틸-서열번호 1의 펩타이드-링커-항암제로 구성되는 항암제 전구체에 관한 것으로, 상기 항암제 전구체는 독소루비신과 같이 산과 염기에 불안정한 항암제를 효과적으로 전구체로 제공함으로써 체내 투여 시에는 비활성 상태의 항암제 전구체로 독성이 없는 상태로 존재하지만, 체내 투여 후 방사선 치료나 UV 치료 후 활성화되는 케스페이즈 존재하에서 활성성분인 항암제가 표적부위에서 효과적으로 방출되므로 암세포에만 선택적으로 항암 효과를 나타낼 수 있어 치료효과의 극대화 및 항암 치료의 부작용을 최소화할 수 있다.

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Номер записи: 22
21-06-2012 дата публикации

PRECURSOR COMPOUND CONNECTED TO SOLID SUPPORT FOR MANUFACTURING 18F RADIOPHARMACEUTICAL, METHOD FOR MANUFACTURING SAME, AND APPLICATION THEREOF

Номер: WO2012081880A3
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, LEE, Jae-Hak, CHU, So-Young, JUNG, Woon-Jung, KWON, Hye-Rim
Принадлежит:

The present invention relates to a solid precursor in the form of an organic salt, the solid precursor having a solid support, a method for manufacturing same, and an application thereof. The solid precursor of the present invention enables omission of the [18F]fluoride refining process using additional cartridge, and the use of excessive phase-transfer catalyst, and can easily remove remaining substance after reaction through the solid support inside the precursor. The solid precursor of the present invention is very appropriate for an automated synthesis device as an all-in-one system that can carry out overall process of [18F]fluorosis reaction, when used by charging in a cartridge.

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Номер записи: 23
04-03-2010 дата публикации

NANOPARTICLE SENSOR FOR MEASURING PROTEASE ACTIVITY AND METHOD FOR MANUFACTURING THE SAME

Номер: WO2010024609A3
Автор: KWON, Ick-Chan, CHOI, Kui-Won, KIM, Kwang-Meyung, YOUN, In-Chan, LEE, Seul-Ki, PARK, Kyeong-Soon, MOON, Dae-Hyuk, CHI, Dae-Yoon, LEE, Seung-Jin, MYUNG, Seung-Jae
Принадлежит:

The present invention relates to a nanoparticle sensor for measuring protease activity for protease imaging and a method for manufacturing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis, and dementia ...

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Номер записи: 24
17-07-2018 дата публикации

１８Ｆ-표지 ＰＥＴ 방사성의약품의 전구체 및 그 제조방법

Номер: KR0101879181B1
Автор: 지대윤, 이병세, 박찬수, 이민형, 차효진, 조우진, 강희원, 김경훈
Принадлежит: (주)퓨쳐켐

... 본 발명은 양전자방출 단층촬영술(PET)용 방사성의약품의 전구체, 그 제조방법과 응용에 관한 것으로, 더욱 상세하게는 4가 유기염의 이탈기를 갖는 전구체, 그 제조방법 및 이를 이용하여 단일 단계로18F를 도입함으로써 짧은 제조시간 내에 원하는 PET 방사성의약품을 높은 방사화학적 수율로 제조하는 방법에 관한 것이다. 본 발명의 4가 유기염 이탈기를 포함하는 전구체는 기존의 다단계의 복잡한 방사성의약품 제조를 단일 단계로 단순화시킬 수 있으며, 과량의 상전이 촉매가 필요 없어 생산 비용을 절감할 수 있고, 반응 후 화합물 분리가 용이하고, 반응속도가 빠른 장점이 있다. 이러한 특징은 자동화 합성 시스템에 의한 PET 방사성의약품 대량생산에 적합하다.

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Номер записи: 25
05-05-2011 дата публикации

(3-FLUORO-2-HYDROXY)PROPYL-FUNCTIONALIZED ARYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENTS FOR THE DIAGNOSIS OR TREATMENT OF NEURODEGENERATIVE BRAIN DISEASES

Номер: WO2011052888A3
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, UTHAIWAN, Sirion, CHU, So-Young, BAE, Yu-Jin, PARK, Chansoo, MOON, Dae-Hyuk, RYU, Jin-Sook, KIM, Jae-Seung, OH, Seung-Jun
Принадлежит:

The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to β-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease. Further, the aryl derivatives of the present invention bind to low molecular β-amyloid peptide conjugates to inhibit the generation of malignant high molecular β-amyloid plaque ...

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Номер записи: 26
08-03-2017 дата публикации

COMPOUND FOR POSITRON EMISSION TOMOGRAPHY IMAGING OF ATHEROSCLEROTIC PLAQUE AND MANUFACTURING METHOD THEREOF

Номер: KR1020170025337A
Автор: CHI, DAE YOON, LEE, BYOUNG SE, CHU, SO YOUNG, CHANG, KI YUK, O, JOO HYUN, PARK, HYO EUN
Принадлежит:

The present invention relates to a compound labeled with a radioactive isotope used in positron emission tomography (PET), for imaging an atherosclerotic plaque, which is a cause of a cardio-cerebrovascular disease, and to a manufacturing method, and to an application thereof. More specifically, two to four peptides which are labeled with the radioactive isotope, and capable of selectively targeting the atherosclerotic plaque are combined, with a small amount and for a short period of time, to an arterial plaque in arteries in which blood flows fast. Therefore, the present invention relates to the compound which can produce excellent PET images, to the manufacturing method, and to the application thereof. COPYRIGHT KIPO 2017 (A1,A2) Mouse 1 ...

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Номер записи: 27
09-03-2017 дата публикации

방사선 또는 자외선 조사에 의해 활성화되는 항암제 전구체 및 이의 용도

Номер: KR0101713888B1
Автор: 류주희, 김광명, 권익찬, 최귀원, 김상윤, 이범석, 지대윤, 길희섭, 성현주
Принадлежит: 한국과학기술연구원

... 본 발명은 아세틸-서열번호 1의 펩타이드-링커-항암제로 구성되는 항암제 전구체에 관한 것으로, 상기 항암제 전구체는 독소루비신과 같이 산과 염기에 불안정한 항암제를 효과적으로 전구체로 제공함으로써 체내 투여 시에는 비활성 상태의 항암제 전구체로 독성이 없는 상태로 존재하지만, 체내 투여 후 방사선 치료나 UV 치료 후 활성화되는 케스페이즈 존재하에서 활성성분인 항암제가 표적부위에서 효과적으로 방출되므로 암세포에만 선택적으로 항암 효과를 나타낼 수 있어 치료효과의 극대화 및 항암 치료의 부작용을 최소화할 수 있다.

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Номер записи: 28
07-09-2012 дата публикации

ANTI-CANCER PRODRUG ACTIVATED BY RADIATION OR ULTRAVIOLET THERAPY AND USE THEREOF

Номер: WO2012118237A1
Автор: RYU, Ju-Hee, KIM, Kwang-Meyung, KWON, Ick-Chan, CHOI, Kui-Won, KIM, Sang-Yoon, LEE, Beom-Suk, CHI, Dae-Yoon, KIL, Hee-Seup, SUNG, Hyun-Ju
Принадлежит:

The present invention relates to an anti-cancer prodrug comprising a peptide having acetyl-sequence No. 1, a linker, and an anti-cancer prodrug. The anti-cancer drug effectively provides, as a prodrug, an anti-cancer drug with an unstable acid-base relationship like doxorubicin, and thus exists as a non-toxic anti-cancer prodrug in an inactive state when administered into the body but effectively releases the anti-cancer drug as an active ingredient from the target area under the presence of caspase activated by radiation or UV treatment after administered. Accordingly, the anti-cancer drug displays selective anti-cancer effects on cancer cells and as such, the effectiveness of the treatment is maximized and the adverse effects of the cancer treatment are minimized.

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Номер записи: 29
21-06-2012 дата публикации

PRECURSOR COMPOUND CONNECTED TO SOLID SUPPORT FOR MANUFACTURING 18F RADIOPHARMACEUTICAL, METHOD FOR MANUFACTURING SAME, AND APPLICATION THEREOF

Номер: WO2012081880A2
Автор: CHI, Dae-Yoon, LEE, Byoung-Se, LEE, Jae-Hak, CHU, So-Young, JUNG, Woon-Jung, KWON, Hye-Rim
Принадлежит:

The present invention relates to a solid precursor in the form of an organic salt, the solid precursor having a solid support, a method for manufacturing same, and an application thereof. The solid precursor of the present invention enables omission of the [18F]fluoride refining process using additional cartridge, and the use of excessive phase-transfer catalyst, and can easily remove remaining substance after reaction through the solid support inside the precursor. The solid precursor of the present invention is very appropriate for an automated synthesis device as an all-in-one system that can carry out overall process of [18F]fluorosis reaction, when used by charging in a cartridge.

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Номер записи: 30
22-11-2012 дата публикации

APPARATUS AND METHOD FOR SYNTHETIZING SYNTHESIZING F-18 LABELED RADIOACTIVE PHARMACEUTICALS

Номер: WO2012157898A3
Автор: LEE, Cheol-Soo, CHI, Dae-Yoon, HEO, Eun-Young, KIM, Jong-Min, LEE, Byoung-Se, KIL, Hee-Seup
Принадлежит:

The present invention relates to an apparatus for synthesizing F-18 labeled radioactive pharmaceuticals. The apparatus for synthesizing F-18 labeled radioactive pharmaceuticals includescomprises: an F-18 radioactive isotope supply part, a reagent supply part, a polymer precursor cartridge, a first heating unit, a polymer compound cartridge, a synthetic container, a second heating unit, a waste solution container, a recovery container, a transfer gas supplying part, a washing solution supplying part, a connecting tube, a plurality of control valves, and a controller.

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Номер записи: 31
02-07-2020 дата публикации

CARBOXYLIC ACID-INTRODUCED PSMA-TARGETING COMPOUND AND USE THEREOF

Номер: WO2020139012A1
Автор: CHI, Dae Yoon, LEE, Byoung Se, CHU, So Young, JEONG, Hyeon Jin, KIM, Min Hwan, LEE, Kyo Chul, LEE, Yong Jin, PARK, Ji Ae, KANG, Choong Mo, LIM, Sang Moo
Принадлежит:

The present invention relates to a18F-labeled compound for diagnosing prostate cancer and a use thereof. The carboxylic acid-introduced compound of the present invention forms strong ion-pair bonds (salt-bridge interactions) with arginine residues present at PSMA protein-binding sites, and thus has high binding affinity, and has rapid background radiation removal effects in vivo due to the hydrophilic properties of carboxylic acid, and less non-specific binding.

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Номер записи: 32
22-11-2012 дата публикации

APPARATUS AND METHOD FOR SYNTHETIZING SYNTHESIZING F-18 LABELED RADIOACTIVE PHARMACEUTICALS

Номер: WO2012157898A2
Автор: LEE, Cheol-Soo, CHI, Dae-Yoon, HEO, Eun-Young, KIM, Jong-Min, LEE, Byoung-Se, KIL, Hee-Seup
Принадлежит:

The present invention relates to an apparatus for synthesizing F-18 labeled radioactive pharmaceuticals. The apparatus for synthesizing F-18 labeled radioactive pharmaceuticals includescomprises: an F-18 radioactive isotope supply part, a reagent supply part, a polymer precursor cartridge, a first heating unit, a polymer compound cartridge, a synthetic container, a second heating unit, a waste solution container, a recovery container, a transfer gas supplying part, a washing solution supplying part, a connecting tube, a plurality of control valves, and a controller.

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Номер записи: 33