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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 32. Отображено 32.
02-04-2018 дата публикации

NOVEL IMIDAZOLYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING CANCER CONTAINING SAME AS ACTIVE INGREDIENT

Номер: KR1020180032784A
Автор: CHOI, HWAN GEUN, KO, EUN KWA, SON, JUNG BEOM, CHO, JOONG HEUI, KIM, NAM DOO, KIM, HYUN KYOUNG
Принадлежит:

The present invention relates to a novel imidazolium pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer containing the same as an active ingredient. The imidazolium pyrimidine derivatives, optical isomers thereof or pharmaceutically acceptable salts thereof according to the present invention are useful not only for an activity of a Wee1 kinase, but also has an excellent effect in inhibiting cell proliferation of liver cancer cell line such that the present invention can be usefully used as a pharmaceutical composition for preventing or treating Wee1 kinase related diseases such as liver cancer preferably, and solid cancer such as liver cancer, lung cancer, colorectal cancer, stomach cancer, breast cancer, colon cancer, bone cancer, pancreatic cancer, head or neck cancer, uterine cancer, ovarian cancer, rectal cancer, esophageal cancer, small bowel cancer, cancer nearby an anus, fallopian tube cancer, endometrial carcinoma ...

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Номер записи: 1
27-09-2018 дата публикации

PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES

Номер: WO2018174650A1
Автор: CHOI, Hwan Geun, KO, Eunhwa, CHO, Joong-heui, SON, Jung Beom, KO, Yi Kyung, PARK, Jin-Hee, KIM, So Young, KANG, Seock Yong, LEE, Seungyeon, RYU, Hee Yoon, KIM, Nam Doo, KIM, Sang Bum, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, CHO, Sungchan, LEE, Kyu-Sun, YU, Kweon, CHOI, Miri, KOO, Ja Wook, HOE, Hyang-Sook
Принадлежит:

The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

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Номер записи: 2
30-08-2018 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND CAPABLE OF PENETRATING BLOOD-BRAIN BARRIER AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BRAIN CANCER

Номер: WO2018155947A1
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, KIM, Nam Doo, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a compound capable of penetrating the blood-brain barrier as an effective ingredient for preventing or treating brain cancer. A pharmaceutical composition for preventing or treating brain cancer according to the present invention efficiently penetrates the blood-brain barrier of the brain to effectively inhibit LRRK2 protein, thus finding useful applications in the prevention or treatment of brain cancer.

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Номер записи: 3
28-12-2017 дата публикации

NOVEL IMIDAZOPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER

Номер: WO2017222287A1
Автор: CHOI, Hwan Geun, SON, Jung Beom, KO, Eunhwa, LEE, Seungyeon, KIM, Shinae, CHO, Joong-heui, KANG, Seock Yong, PARK, Jin-Hee, KIM, So Young, KO, Yi Kyung, JANG, Bo Mi, RYU, Hee Yoon, KIM, Nam Doo, KIM, Hyunkyoung, LEE, Yunho, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, HONG, Seong-Ho, MIN, Sang Hyun, LEE, Sungwoo, CHOI, Dong Kyu, MA, Minjung, KIM, Sang Bum, YOON, Suk Kyoon, KANG, Yoon-Koo
Принадлежит:

The present invention relates to a novel imidazopyridine derivative, a method for preparing same, and a pharmaceutical composition containing same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof, and pharmaceutically acceptable salts thereof can effectively inhibit cancer cell-related kinase, are excellent in inhibiting the proliferation of cancer cells in a cancer cell line, and effectively inhibit the proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful in a pharmaceutical composition containing same as an active ingredient for preventing or treating cancer. Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salts thereof can effectively inhibit Src and Fyn, thereby being useful in a pharmaceutical composition for preventing or treating ...

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Номер записи: 4
06-12-2018 дата публикации

PYRROLO-PYRIMIDINE DERIVATIVE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME COMPOUND AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE

Номер: WO2018155916A3
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, CHO, Joong-heui, KO, Yi Kyung, PARK, Jin-Hee, KIM, So Young, KANG, Seock Yong, LEE, Seungyeon, KIM, Nam Doo, LEE, Yunho, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, BAE, Jae Hyun, HONG, Eunmi, JANG, Tae-ho, KIM, Sang Bum, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.

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Номер записи: 5
28-09-2017 дата публикации

NOVEL PYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING FGFR-RELATED DISEASE CONTAINING SAME AS ACTIVE COMPONENT

Номер: WO2017164705A1
Автор: CHOI, Hwan Geun, AHN, Sung-Min, SON, Jung Beom, KIM, Nam Doo, KIM, So Young, KANG, Seock Yong, RYU, Hee Yoon, KIM, Hyunkyoung, BAE, Jae Hyun, KIM, Sunghwan, SON, Youngjin
Принадлежит:

The present invention relates to a novel pyridine derivative, a method for preparing same, and a pharmaceutical composition which contains same as an active component and is for preventing or treating fibroblast growth factor receptor (FGFR)-related disease. A novel pyridine derivative according to the present invention, an optical isomer thereof, and a pharmaceutically acceptable salt of the pyridine derivative can effectively inhibit a fibroblast growth factor receptor (FGFR), and thus FGFR-related disease, preferably has a useful effect on the prevention and treatment of cancer.

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Номер записи: 6
10-09-2018 дата публикации

PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR MANUFACTURING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE CONTAINING SAME AS ACTIVE INGREDIENT

Номер: KR101896568B1
Автор: CHOI HWAN GEUN, KO EUNHWA, CHO JOONG HEUI, SON JUNG BEOM, KO YI KYUNG, PARK JIN HEE, KIM SO YOUNG, KANG SEOCK YONG, LEE SEUNGYEON, RYU HEE YOON, KIM NAM DOO, KIM SANG BUM, LEE SUN HWA, KIM DAYEA, LEE SUN JOO, CHO SUNGCHAN, LEE KYU SUN, YU KWEON, CHOI MIRI, KOO JA WOOK, HOE HYANG SOOK
Принадлежит: DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION, KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

The present invention relates to a pyrrolo-pyridine derivative compound, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating a protein kinase-related disease containing the compound as an active ingredient. The compound represented by chemical formula 1, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention is excellent in an inhibitory activity against various protein kinases including DYRK1A. Therefore, a pharmaceutical composition containing the compound as an active ingredient can be usefully used for treating or preventing a protein kinase-related disease. In particular, the compound can be effectively used for prevention, treatment or alleviation of Alzheimer′s disease, dementia or Alzheimer′s dementia. COPYRIGHT KIPO 2018 ...

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Номер записи: 7
24-12-2018 дата публикации

NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR

Номер: KR1020180136425A
Автор: SIM TAE BO, HUR WOO YOUNG, SONG CHI MAN, YOON HO JONG, CHOI SEUNG HYE, CHO HAN NA, CHOI HWAN GEUN, KIM NAM DOO, SON JUNG BEOM, KO EUN HWA, KIM HYUN KYOUNG, CHO JOONG HEUI, KANG SEOCK YONG, KIM SO YOUNG, KO YI KYUNG, LEE SEUNG YEON, YOON SUK KYOON, BAE JAE HYUN
Принадлежит:

The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent comprising the compound as an active ingredient, and a method of preparing the compound. COPYRIGHT KIPO 2019 ...

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Номер записи: 8
24-08-2017 дата публикации

NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR

Номер: KR1020170096599A
Автор: SIM, TAE BO, HUR, WOO YOUNG, SONG, CHI MAN, YOON, HO JONG, CHOI, SEUNG HYE, CHO, HAN NA, CHOI, HWAN GEUN, KIM, NAM DOO, SON, JUNG BEOM, KO, EUN HWA, KIM, HYUN KYOUNG, CHO, JOONG HEUI, KANG, SEOCK YONG, KIM, SO YOUNG, KO, YI KYUNG, LEE, SEUNG YEON, YOON, SUK KYOON, BAE, JAE HYUN
Принадлежит:

The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent comprising the compound as an active ingredient, and a method of preparing the compound. According to the present invention, the 2,3,5-substituted thiophene compound has inhibitory activity on the proliferation of FLT3-ITD-positive leukemia cell line and Ba/F3 cell line, and has superior inhibitory activity on drug-resistant FLT3 mutations as well, and thus is effective in the treatment of acute myeloid leukemia. COPYRIGHT KIPO 2017 ...

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Номер записи: 9
12-12-2018 дата публикации

PYRROLOPYRIMIDINE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES PYRROLOPYRIMIDINE DERIVATIVE COMPOUND

Номер: KR1020180132575A
Автор: CHOI HWAN GEUN, PARK JONG BAE, KO EUNHWA, SON JUNG BEOM, CHO JOONG HEUI, KO YI KYUNG, PARK JIN HEE, KIM SO YOUNG, KANG SEOCK YONG, LEE SEUNGYEON, KIM NAM DOO, LEE YUNHO, LEE SUN HWA, KIM DAYEA, LEE SUN JOO, BAE JAE HYUN, HONG EUNMI, JANG TAE HO, KIM SANG BUM, LEE SEUNG HOON, NAM DO HYUN
Принадлежит:

The present invention relates to a noble pyrrolopyrimidine derivative compound, a preparation method thereof, and a pharmaceutical composition for preventing or treating protein kinase-related diseases comprising the pyrrolopyrimidine derivative compound as an active ingredient. According to the present invention, a compound represented by chemical formula 1, optical isomers thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compound as an active ingredient have superior inhibiting activities with respect to LRRK2 kinase and have excellent phosphorylation inhibiting effects in NIH-3T3 cell line, LRRK2 expression cell line, and NCC01 and 448T cell lines, cell lines derived from a brain tumor patient. Further, it has been checked through experiments that the compound, the optical isomers or the pharmaceutically acceptable salts, and the pharmaceutical composition have inhibiting activities with respect to various protein kinases in addition ...

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Номер записи: 10
14-11-2019 дата публикации

NOVEL COMPOUND EXHIBITING ENTEROPEPTIDASE INHIBITORY ACTIVITY

Номер: WO2019216742A1
Автор: KIM, Young Kwan, KWON, Ohhwan, PARK, Heedong, PARK, Junggyu, CHOI, Hwan Geun, SON, Jung Beom, KO, Eunhwa, KIM, So Young, LEE, Seungyeon, KANG, Seock Yong, KO, Yi Kyung, PARK, Jin-Hee
Принадлежит:

The present invention relates to: a novel compound exhibiting enteropeptidase inhibitory activity; a pharmaceutically acceptable salt thereof; a pharmaceutical composition for metabolic diseases such as obesity, diabetes, or hyperlipidemia, including the compound or a pharmaceutically acceptable salt thereof; and a method for preventing or treating metabolic diseases using the novel compound. The compound of the present invention enables, due to excellent enteropeptidase inhibitory activity, not only fats but also proteins to be excreted when ingested foods are excreted, not absorbed, from the body, resulting in fewer side effects such as fatty stool, and acts only on the gastrointestinal tract, thus reducing side effects such as depression. Thus, the compound of the present invention is very useful as an agent for the treatment or prevention of various metabolic diseases such as obesity, diabetes, and hyperlipidemia.

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Номер записи: 11
27-12-2017 дата публикации

4-((2-ACRYLAMIDOPHENYL)AMINO)THIENO[3,2-D]PYRIMIDINE-7-CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL APPLICATIONS THEREOF

Номер: KR101812266B1
Автор: SIM, TAE BO, YOON, HO JONG, SHIN, IN JAE, NAM, YUN JU, CHOI, HWAN GEUN
Принадлежит: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

The present invention relates to a novel 4-((2-acrylamidophenyl) amino)thieno[3,2-d]pyrimidine-7-carboxamide compound; an anticancer agent comprising the compound as an active ingredient; and an intermediate compound for the preparation of the compound. COPYRIGHT KIPO 2018 ...

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Номер записи: 12
27-09-2018 дата публикации

PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES

Номер: WO2018174650A9
Автор: CHOI, Hwan Geun, KO, Eunhwa, CHO, Joong-heui, SON, Jung Beom, KO, Yi Kyung, PARK, Jin-Hee, KIM, So Young, KANG, Seock Yong, LEE, Seungyeon, RYU, Hee Yoon, KIM, Nam Doo, KIM, Sang Bum, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, CHO, Sungchan, LEE, Kyu-Sun, YU, Kweon, CHOI, Miri, KOO, Ja Wook, HOE, Hyang-Sook
Принадлежит:

The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

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Номер записи: 13
27-02-2020 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BRAIN CANCER, COMPRISING, AS ACTIVE INGREDIENT, COMPOUND CAPABLE OF PENETRATING BLOOD-BRAIN BARRIER

Номер: WO2020040610A1
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, KIM, Nam Doo, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating brain cancer, comprising, as an active ingredient, a compound capable of penetrating the blood-brain barrier. The pharmaceutical composition for preventing or treating brain cancer, according to the present invention, efficiently penetrates the blood-brain barrier of the brain and effectively inhibits an LRRK2 protein, thereby being effectively usable in the prevention or treatment of brain cancer.

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Номер записи: 14
21-02-2018 дата публикации

UREA COMPOUND HAVING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE BACKBONE WITH PROTEIN KINASE INHIBITORY FUNCTIONS

Номер: KR1020180017549A
Автор: SIM, TAE BO, HUR, WOO YOUNG, YOON, HO JONG, SONG, CHI MAN, JU, EUN HYE, CHO, HAN NA, CHOI, HWAN GEUN
Принадлежит:

The present invention relates to a pharmaceutical composition containing a urea compound having a 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one backbone exhibiting protein kinase inhibitory functions, and a pharmaceutically acceptable salt thereof as an active ingredient. COPYRIGHT KIPO 2018 (A1,A2) Display (B1,B2) % inhibitory activity ...

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Номер записи: 15
21-11-2019 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING TRAUMATIC BRAIN INJURY OR STROKE

Номер: WO2019221566A1
Автор: CHOI, Hwan Geun, KO, Eunhwa, KO, Yi Kyung, PARK, Jin-Hee, LEE, Taekwan, KIM, Heejaung, LEE, Byoung Dae, BOO, Yung Min, BAE, Jinhyun, BAE, Yun-Hee
Принадлежит:

The present invention pertains to a pharmaceutical composition for preventing or treating traumatic brain injury or stroke. The pharmaceutical composition contains an LRRK2 inhibitor as an active ingredient, and can be useful in the treatment of traumatic brain injury or stroke due to being highly effective in terms of inhibiting the expression of wild-type LRRK2 which is overexpressed in traumatic brain injury or stroke, protecting or repairing damage to neurons induced by traumatic brain injury or stroke, improving neurological behavioral outcomes or neuropathy occurring after traumatic brain injury, and treating, alleviating, or ameliorating brain pathologies caused by traumatic brain injury.

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Номер записи: 16
30-08-2018 дата публикации

PYRROLOPYRIMIDINE DERIVATIVE COMPOUND, METHOD FOR MANUFACTURING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE CONTAINING COMPOUND AS ACTIVE INGREDIENT

Номер: KR1020180097162A
Автор: CHOI, HWAN GEUN, PARK, JONG BAE, KO, EUN HWA, SON, JUNG BEOM, CHO, JOONG HEUI, KO, YI KYUNG, PARK, JIN HEE, KIM, SO YOUNG, KANG, SEOCK YONG, LEE, SEUNG YEON, KIM, NAM DOO, LEE, YUN HO, LEE, SUN HWA, KIM, DA YEA, LEE, SUN JOO, BAE, JAE HYUN, HONG, EUN MI, JANG, TAE HO, KIM, SANG BUM, LEE, SEUNG HOON, NAM, DO HYUN
Принадлежит:

The present invention relates to a novel pyrrolopyrimidine derivative compound, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating a protein kinase-related disease containing the compound as an active ingredient. The pharmaceutical composition comprising the compound represented by chemical formula 1, an optical isomer thereof or a pharmaceutically acceptable salt thereof as an active ingredient is excellent in inhibitory activity against LRRK2 kinase and is excellent in phosphorylation inhibition of an LRRK2 expressing NIH-3T3 cell line, and NCC01 and 448T cell lines derived from brain tumor patients. Furthermore, since the composition is confirmed through experimentation to have inhibitory activity against various protein kinases including LRRK2, the composition can be effectively used for the treatment or prevention of protein kinase-related diseases. COPYRIGHT KIPO 2018 ...

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Номер записи: 17
03-05-2018 дата публикации

1,6-이치환된 인돌 화합물을 함유하는 약물 내성 및 부작용이 저감된 만성골수성백혈병 치료제

Номер: KR0101854117B1
Автор: 심태보, 윤호종, 허우영, 남윤주, 최환근
Принадлежит: 한국과학기술연구원

... 본 발명은 1,6-이치환된 인돌 화합물을 함유하는 약물 내성 및 부작용이 저감된 만성골수성백혈병 치료제에 관한 것이다.

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Номер записи: 18
29-12-2017 дата публикации

NOVEL IMIDAZOPYRIDINE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT

Номер: KR1020170143456A
Автор: CHOI, HWAN GEUN, SON, JUNG BEOM, KIM, SHIN AE, LEE, SEUNG YEON, KO, EUN HWA, CHO, JOONG HEUI, KANG, SEOCK YONG, KIM, SO YOUNG, PARK, JIN HEE, KO, YI KYUNG, RYU, HEE YOON, KIM, NAM DOO, KIM, HYUN KYOUNG, LEE, YOUN HO, LEE, SUN HWA, KIM, DA YEA, LEE, SUN JOO, HONG, SEONG HO, MIN, SANG HYUN, LEE, SUNG WOO, CHOI, DONG KYU, BAE, JAE HYUN, HONG, EUN MI, JANG, TAE HO, SONG, JAE YOUNG, KIM, SANG BUM, YOON, SUK KYOON
Принадлежит:

The present invention relates to a novel imidazopyridine derivative, a method of preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof, and pharmaceutically acceptable salts thereof can effectively inhibit cancer-related kinase, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer. Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salts thereof can effectively inhibit Src and Fyn, thereby being useful as a pharmaceutical composition for preventing or treating ...

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Номер записи: 19
21-12-2018 дата публикации

신규한 이미다조피리딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물

Номер: KR0101931435B1
Автор: 최환근, 손정범, 김신애, 이승연, 고은화, 조중희, 강석용, 김소영, 박진희, 고이경, 류희윤, 김남두, 김현경, 이윤호, 이선화, 김다예, 이선주, 홍성호, 민상현, 이성우, 최동규, 배재현, 홍은미, 장태호, 송재영, 김상범, 윤석균
Принадлежит: 재단법인 대구경북첨단의료산업진흥재단

... 본 발명은 신규한 이미다조피리딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 이미다조피리딘 유도체, 이의 입체 이성질체 및 이의 약학적으로 허용 가능한 염은, 암세포 관련 효소(kinase)를 효과적으로 저해할 수 있고, 암 세포주에서 암의 세포 증식을 우수하게 억제할 수 있을 뿐 아니라, 암 세포 이종이식 모델에서 또한 암세포 증식 억제(암 세포 사멸) 효과가 있는 바, 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다. 또한, 본 발명에 따른 신규한 이미다조피리딘 유도체, 이의 입체 이성질체 및 이의 약학적으로 허용 가능한 염은, Src 및 Fyn을 효과적으로 저해할 수 있는 바, 이와 관련된 질환의 예방 또는 치료용 약학적 조성물로 유용할 수 있고, 특히 동물 모델 실험에서 당뇨병성 신증에 유용할 수 있음을 확인한 바, 본 발명 화합물은 이를 유효성분으로 함유하는 당뇨병성 신증의 예방 또는 치료용 약학적 조성물로 유용한 효과가 있다.

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Номер записи: 20
29-03-2018 дата публикации

NOVEL IMIDAZOLYL PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER

Номер: WO2018056621A1
Автор: CHOI, Hwan Geun, KO, Eunhwa, SON, Jung Beom, CHO, Joongheui, KIM, Nam Doo, KIM, Hyunkyoung
Принадлежит:

The present invention relates to a novel imidazolyl pyrimidine derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for prevention or treatment of cancer.

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Номер записи: 21
20-02-2020 дата публикации

SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT

Номер: WO2020036437A1
Автор: CHOI, Hwan Geun, KO, Eunhua, PARK, Jin-Hee, KO, Yi Kyung, KANG, Seock Yong, KIM, So Young, JANG, Bo Mi, LEE, Seungyeon, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, KIM, Sang Bum, PARK, Jong Bae, NAM, Do-Hyun
Принадлежит:

The present invention pertains to: a substituted heteroaryl derivative; a method for producing same; and a pharmaceutical composition which contains same as an active ingredient and is for preventing or treating protein kinase-related diseases. Since the substituted heteroaryl derivative has excellent inhibitory activity against various protein kinases including LRRK2, a pharmaceutical composition containing the substituted heteroaryl derivative as an active ingredient can be useful for treating or preventing protein kinase-related diseases.

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Номер записи: 22
13-10-2017 дата публикации

NOVEL PYRIDINE DERIVATIVE, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING FGFR-ASSOCIATED DISEASES CONTAINING SAME AS ACTIVE INGREDIENT

Номер: KR1020170114254A
Автор: CHOI, HWAN GEUN, AHN, SUNG MIN, SON, JUNG BEOM, KIM, NAM DOO, KIM, SO YOUNG, KANG, SEOCK YONG, RYU, HEE YOON, KIM, HYUN KYOUNG, BAE, JAE HYUN, KIM, SUNG HWAN, SON, YOUNG JIN
Принадлежит:

The present invention relates to a novel pyridine derivative, a production method thereof, and a pharmaceutical composition for preventing and treating fibroblast growth factor receptor (FGFR)-associated diseases containing the same as an active ingredient according to the present invention, the novel pyridine derivative, an optical isomer thereof, and a pharmaceutically acceptable salt thereof effectively inhibits FGFR, thereby being useful for preventing or treating FGFR-associated diseases, favorably cancer. COPYRIGHT KIPO 2017 ...

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Номер записи: 23
28-12-2017 дата публикации

NOVEL IMIDAZOPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CANCER

Номер: WO2017222285A1
Автор: CHOI, Hwan Geun, SON, Jung Beom, KIM, Shinae, LEE, Seungyeon, KO, Eunhwa, CHO, Joongheui, KANG, Seock Yong, KIM, So Young, PARK, Jin-Hee, KO, Yi Kyung, RYU, Hee Yoon, KIM, Nam Doo, KIM, Hyunkyoung, LEE, Younho, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, HONG, Seongho, MIN, Sang Hyun, LEE, Sungwoo, CHOI, Dong Kyu, BAE, Jae Hyun, HONG, Eunmi, JANG, Tae-ho, SONG, Jaeyoung, KIM, Sangbum, YOON, Suk Kyoon
Принадлежит:

The present invention relates to a novel imidazopyridine derivative, a method for preparing same, and a pharmaceutical composition containing same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof, and pharmaceutically acceptable salts thereof can effectively inhibit cancer-related kinase, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition containing same as an active ingredient for preventing or treating cancer. Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salts thereof can effectively inhibit Src and Fyn, thereby being useful as a pharmaceutical composition for preventing or treating related ...

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Номер записи: 24
24-08-2017 дата публикации

NOVEL 2,3,5-SUBSTITUTED THIOPHENE COMPOUND AS PROTEIN KINASE INHIBITOR

Номер: WO2017142325A1
Автор: SIM, Tae Bo, HUR, Woo Young, SONG, Chi Man, YOON, Ho Jong, CHOI, Seung Hye, CHO, Han Na, CHOI, Hwan Geun, KIM, Nam Doo, SON, Jung Beom, KO, Eun Hwa, KIM, Hyun Kyoung, CHO, Joong Heui, KANG, Seock Yong, KIM, So Young, KO, Yi Kyung, LEE, Seung Yeon, YOON, Suk Kyoon, BAE, Jae Hyun
Принадлежит:

... [Summary] The present invention relates to a novel 2,3,5-substituted thiophene compound having an inhibitory activity against kinases, an anticancer agent comprising the compound as an active ingredient, and a preparation method of the compound.

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Номер записи: 25
15-02-2018 дата публикации

UREA COMPOUND HAVING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE SKELETON HAVING PROTEIN KINASE INHIBITING ACTIVITY

Номер: WO2018030800A1
Автор: SIM, Tae Bo, HUR, Woo Young, YOON, Ho Jong, SONG, Chi Man, JU, Eun Hye, CHO, Han Na, CHOI, Hwan Geun
Принадлежит:

The present invention relates to a urea compound having a 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one skeleton and having a protein kinase inhibiting activity, and to a pharmaceutical composition containing a pharmaceutically acceptable salt as an active ingredient.

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Номер записи: 26
30-08-2018 дата публикации

PYRROLO-PYRIMIDINE DERIVATIVE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME COMPOUND AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE

Номер: WO2018155916A2
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, CHO, Joong-heui, KO, Yi Kyung, PARK, Jin-Hee, KIM, So Young, KANG, Seock Yong, LEE, Seungyeon, KIM, Nam Doo, LEE, Yunho, LEE, Sun-Hwa, KIM, Dayea, LEE, Sun Joo, BAE, Jae Hyun, HONG, Eunmi, JANG, Tae-ho, KIM, Sang Bum, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.

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Номер записи: 27
12-09-2018 дата публикации

단백질 키나아제 저해 활성을 갖는 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 골격의 유레아 화합물

Номер: KR0101897631B1
Автор: 심태보, 허우영, 윤호종, 송치만, 주은혜, 조한나, 최환근
Принадлежит: 한국과학기술연구원

... 본 발명은 단백질 키나아제 저해 활성을 보유한 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 골격을 갖는 유레아 화합물 및 약학적으로 허용 가능한 염이 유효 성분으로 함유되어 있는 약학 조성물에 관한 것이다.

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Номер записи: 28
26-02-2018 дата публикации

CHRONIC MYELOGENOUS LEUKEMIA THERAPEUTIC AGENT WITH REDUCED DRUG RESISTANCE AND SIDE EFFECTS CONTAINING 1,6-DISUBSTITUTED INDOLE COMPOUND

Номер: KR1020180019443A
Автор: SIM, TAE BO, YOON, HO JONG, HUR, WOO YOUNG, NAM, YUN JU, CHOI, HWAN GEUN
Принадлежит:

The present invention relates to a chronic myelogenous leukemia therapeutic agent with reduced drug resistance and side effects containing a 1,6-disubstituted indole compound. COPYRIGHT KIPO 2018 (AA) Excipient control group (BB) Imatinib (C1,C2) Day 1 (D1,D2) Day 5 (E1,E2) Day 9 (FF) Ponatinib (GG) Compound number 1 ...

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Номер записи: 29
21-11-2018 дата публикации

신규한 이미다조피리딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물

Номер: KR0101920456B1
Автор: 최환근, 손정범, 고은화, 이승연, 김신애, 조중희, 강석용, 박진희, 김소영, 고이경, 장보미, 류희윤, 김남두, 김현경, 이윤호, 이선화, 김다예, 이선주, 홍성호, 민상현, 이성우, 최동규, 마민정, 김상범, 윤석균, 강윤구
Принадлежит: 재단법인 대구경북첨단의료산업진흥재단, 재단법인 아산사회복지재단, 울산대학교 산학협력단

... 본 발명은 신규한 이미다조피리딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 이미다조피리딘 유도체, 이의 입체 이성질체 및 이의 약학적으로 허용 가능한 염은, 암세포 관련 효소(kinase)를 효과적으로 저해할 수 있고, 암 세포주에서 암의 세포 증식을 우수하게 억제할 수 있을 뿐 아니라, 암 세포 이종이식 모델에서 또한 암세포 증식 억제(암 세포 사멸) 효과가 있는 바, 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다. 또한, 본 발명에 따른 신규한 이미다조피리딘 유도체, 이의 입체 이성질체 및 이의 약학적으로 허용 가능한 염은, Src 및 Fyn을 효과적으로 저해할 수 있는 바, 이와 관련된 질환의 예방 또는 치료용 약학적 조성물로 유용할 수 있고, 예를 들어 당뇨병성 신증의 예방 또는 치료용 약학적 조성물로 유용한 효과가 있다.

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Номер записи: 30
29-12-2017 дата публикации

NOVEL IMIDAZOPYRIDINE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT

Номер: KR1020170143457A
Автор: CHOI, HWAN GEUN, SON, JUNG BEOM, KO, EUN HWA, LEE, SEUNG YEON, KIM, SHIN AE, CHO, JOONG HEUI, KANG, SEOCK YONG, PARK, JIN HEE, KIM, SO YOUNG, KO, YI KYUNG, JANG, BO MI, RYU, HEE YOON, KIM, NAM DOO, KIM, HYUN KYOUNG, LEE, YUN HO, LEE, SUN HWA, KIM, DA YEA, LEE, SUN JOO, HONG, SEONG HO, MIN, SANG HYUN, LEE, SUNG WOO, CHOI, DONG KYU, MA, MIN JUNG, KIM, SANG BUM, YOON, SUK KYOON
Принадлежит:

The present invention relates to a novel imidazopyridine derivative, a method of preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof, and pharmaceutically acceptable salts thereof can effectively inhibit cancer cell-related kinase, are excellent in inhibiting the proliferation of cancer cells in a cancer cell line, and effectively inhibit the proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful in a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer. Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salts thereof can effectively inhibit Src and Fyn, thereby being useful in a pharmaceutical composition for preventing ...

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Номер записи: 31
27-02-2020 дата публикации

NOVEL USE OF PYRIMIDINE DERIVATIVE COMPRISING LRRK KINASE INHIBITOR AS EFFECTIVE INGREDIENT

Номер: WO2020040591A1
Автор: CHOI, Hwan Geun, PARK, Jong Bae, KO, Eunhwa, SON, Jung Beom, KIM, Nam Doo, LEE, Seung Hoon, NAM, Do-Hyun
Принадлежит:

The present invention relates to a novel use of a pyrimidine derivative comprising an LRRK kinase inhibitor as an effective ingredient. A pharmaceutical composition, provided according to one aspect of the present invention, for prevention or treatment of at least one selected from pancreatic cancer, breast cancer, and lung cancer exhibits an excellent therapeutic effect on cancer in vitro and in vivo and, as such, can be advantageously used as a therapeutic agent for pancreatic cancer, breast cancer, and lung cancer.

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Номер записи: 32