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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 8. Отображено 8.
12-01-2018 дата публикации

THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE DERIVATIVES

Номер: KR101818130B1
Автор: SIM, TAE BO, CHO, HAN NA, JU, EUN HYE, HUR, WOO YOUNG, YOON, HO JONG, SONG, CHI MAN
Принадлежит: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

The present invention relates to a therapeutic agent of acute myeloid leukemia containing 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one compounds as active ingredients. The therapeutic agent has a low activity of inhibiting wild-NRAS and has an activity of inhibiting proliferation with respect to human acute myeloid leukemia strain (OCI-AML3), and has an activity of inhibiting GCK and ACK1 protein kinase at the same time. COPYRIGHT KIPO 2018 ...

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Номер записи: 1
18-06-2018 дата публикации

NOVEL α1-ADRENERGIC RECEPTOR AGONIST

Номер: KR1020180065636A
Автор: SEO, HONG SEOG, SHIM, TAE BO, LEE, YONG JIK, SANDIP SENGUPTA, JU, EUN HYE
Принадлежит:

The present invention relates to a novel α1-adrenergic receptor agonist, and more particularly, to a novel analogue of midodrine which is α1-adrenergic receptor agonist. The midodrine analogue of the present invention increase an expression of p-AMPK, PPARδ, PGC-1α, which are essential for maintaining and regulating in vivo energy metabolism activity, thereby being usefully used for preventing or treating diseases (such as metabolic diseases, cardiovascular diseases, inflammatory diseases, etc.) in which activation of AMPK is required. COPYRIGHT KIPO 2018 ...

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Номер записи: 2
24-03-2017 дата публикации

SLURRY FOR POLISHING ALUMINIUM-CONTAINING SUBSTRATES

Номер: KR101719787B1
Автор: KIM, MOON SUNG, LEE, JONG HOON, PARK, CHUL JIN, LEE, SEOK HOON, KIM, GYU SU, PARK, YONG HO, KWAK, NA RAE, JU, EUN HYE
Принадлежит: ACE NANOCHEM CO., LTD.

The present invention relates to a slurry for polishing aluminium-containing substrates. To this end, the slurry for polishing aluminium-containing substrates comprises: a colloidal silica polishing particle; an oxidizer; and at least one additive selected from the group consisting of a polishing accelerator, an anti-defection agent, a surface improver, and a pH regulator. COPYRIGHT KIPO 2017 ...

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Номер записи: 3
21-02-2018 дата публикации

UREA COMPOUND HAVING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE BACKBONE WITH PROTEIN KINASE INHIBITORY FUNCTIONS

Номер: KR1020180017549A
Автор: SIM, TAE BO, HUR, WOO YOUNG, YOON, HO JONG, SONG, CHI MAN, JU, EUN HYE, CHO, HAN NA, CHOI, HWAN GEUN
Принадлежит:

The present invention relates to a pharmaceutical composition containing a urea compound having a 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one backbone exhibiting protein kinase inhibitory functions, and a pharmaceutically acceptable salt thereof as an active ingredient. COPYRIGHT KIPO 2018 (A1,A2) Display (B1,B2) % inhibitory activity ...

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Номер записи: 4
04-10-2018 дата публикации

신규한 α1-아드레날린 수용체 효능제

Номер: KR0101903592B1
Автор: 서홍석, 심태보, 이용직, 산딥 센굽타, 주은혜
Принадлежит: 고려대학교 산학협력단, 한국과학기술연구원

... 본 발명은 신규한 α1-아드레날린 수용체 효능제에 관한 것으로, 보다 상세하게는 α1-아드레날린 수용체 효능제인 미도드린의 신규한 유사체에 관한 것이다. 본 발명의 미도드린 유사체는 생체내 에너지 대사활성 유지와 조절에 핵심적인 작용을 하는 p-AMPK, PPARδ, PGC-1α의 발현을 증가시킴으로써, AMPK의 활성화가 필요한 질환(대사질환, 심혈관질환, 염증질환 등)의 예방 및 치료에 유용하게 이용될 수 있다.

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Номер записи: 5
15-02-2018 дата публикации

UREA COMPOUND HAVING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE SKELETON HAVING PROTEIN KINASE INHIBITING ACTIVITY

Номер: WO2018030800A1
Автор: SIM, Tae Bo, HUR, Woo Young, YOON, Ho Jong, SONG, Chi Man, JU, Eun Hye, CHO, Han Na, CHOI, Hwan Geun
Принадлежит:

The present invention relates to a urea compound having a 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one skeleton and having a protein kinase inhibiting activity, and to a pharmaceutical composition containing a pharmaceutically acceptable salt as an active ingredient.

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Номер записи: 6
20-06-2017 дата публикации

REFRIGERATOR

Номер: KR1020170068794A
Автор: LEE, TAE YOUL, JANG, BOK HYUN, KIM, HYUN JOO, JOO, EUN HEA, HWANG, IN SUNG
Принадлежит:

The present invention relates to a refrigerator, which has an improved structure of a slide unit, which slides a door guard, to easily separate the door guard from a door. According to the present invention, the refrigerator comprises: a case which is fixated on the rear surface of a door of the refrigerator, and has an opening unit on the front surface; a door guard which is separately accommodated in the case; and a slide unit which allows the door guard to be put in and taken out through the opening unit. The slide unit comprises: guide rails which are placed on both sides on the bottom of the door guard; a guide unit which is placed on the case, guides the guide rails, and is inclined upwards from the rear end portion towards the front end portion; a fixing rib which is placed on the rear end of the guide unit, and has a chamfer unit formed to be streamlined upward on the front end portion; and a support rib which is placed on the door guard, is supported by the fixing rib, and prevents ...

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Номер записи: 7
12-09-2018 дата публикации

단백질 키나아제 저해 활성을 갖는 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 골격의 유레아 화합물

Номер: KR0101897631B1
Автор: 심태보, 허우영, 윤호종, 송치만, 주은혜, 조한나, 최환근
Принадлежит: 한국과학기술연구원

... 본 발명은 단백질 키나아제 저해 활성을 보유한 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 골격을 갖는 유레아 화합물 및 약학적으로 허용 가능한 염이 유효 성분으로 함유되어 있는 약학 조성물에 관한 것이다.

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Номер записи: 8