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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 13. Отображено 13.
28-05-2018 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING COMPOUND K AS EFFECTIVE COMPONENT FOR PREVENTING OR TREATING OF KERATOCONJUNCTIVITIS

Номер: KR101861579B1
Автор: KANG, JAE SEON, LEE YOUN JE, JUNG CHUNG KI, KIM KANG MIN, LEE JIN YOUNG, PYO JAE SUNG, KIM HYUNG HOI, KIM CHEOL MIN, KIM HYEONG SOO
Принадлежит: KYUNGSUNG UNIVERSITY INDUSTRY COOPERATION FOUNDATION

The present invention relates to a pharmaceutical composition comprising compound K as an effective component for preventing or treating of keratoconjunctivitis. The compound K is confirmed to have a treatment effect on keratoconjunctivitis through inhibiting keratocyte damage and keratocyte apoptosis due to the damage, and thus the compound K of the present invention can be used as a therapeutic agent for keratoconjunctivitis. COPYRIGHT KIPO 2018 (A1,A2) Normal bacteria (B1,B2) Control group (keratoconjunctivitis induction) (C1,C2) Experimental group 1 (Compound K 0.5 mg / kg administered) (D1,D2) Experimental group 2 (Compound K 1 mg / kg administered) ...

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Номер записи: 1
20-04-2017 дата публикации

METHOD FOR PREPARING HOMOGENEOUS SOLUTION FORMULATION FOR SOLUBILIZING SPARINGLY SOLUBLE PHARMACOLOGICALLY ACTIVE INGREDIENT USING ETHANOL AND ALKALINE AMINO ACID

Номер: KR101728799B1
Автор: KANG, JAE SEON, JUNG, CHUNG KI, KANG, JUN HO, JI, YOUNG HOON, PYO, JAE SUNG, KWON, CHA NAM, KIM, SEONG HO
Принадлежит: KYUNGSUNG UNIVERSITY INDUSTRY COOPERATION FOUNDATION

The present invention relates to an injection formulation and eye drop formulation formed into a homogeneous solution by solubilizing sparingly soluble pharmacologically active ingredients, and a method for preparing the same. Particularly, the injection formulation and eye drop formulation are formed into a homogeneous solution by mixing and dissolving a sparingly soluble material which has a pharmacologically active ingredient and is slightly soluble in an alcohol but insoluble in water with a detergent, ethanol and a solubilizer so that the sparingly soluble pharmacologically active ingredient may be solubilized. Preferably, the sparingly soluble material is rebamipide or curcumin, and the solubilizer is any one of alkaline amino acids including histidine, lysine and arginine or a combination thereof. Therefore, it is possible to obtain a homogeneous solution containing a sparingly soluble drug and to provide an injection formulation and eye drop formulation causing no precipitation ...

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Номер записи: 2
18-04-2018 дата публикации

METHOD FOR PRODUCING GINSENG SAPONIN

Номер: KR1020180039539A
Автор: KANG, JAE SEON, KANG, JUN HO, PYO, JAE SUNG, KIM, KANG MIN, CHEON, HAE IN, KIM, HYUNG HOI
Принадлежит:

The present invention relates to a method for producing ginseng saponin. The method comprises: a step (S1) of extracting ginseng saponin by alcohol; a step (S2) of preparing a ginseng saponin solution; and a step (S3) of obtaining a concentrate. Active ginseng saponin which is not soluble in water but has a higher level of in vivo absorptivity to exhibit an effect well can be mass-produced. COPYRIGHT KIPO 2018 ...

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Номер записи: 3
03-12-2015 дата публикации

PHARMACEUTICAL COMPOSITION EXHIBITING EFFECTS OF PREVENTING DECREASE IN WHITE BLOOD CELLS AND RESTORING WHITE BLOOD CELLS, CONTAINING ANGELICA GIGAS NAKAI EXTRACT AS ACTIVE INGREDIENT

Номер: WO2015182865A1
Автор: KANG, Jae Seon, JI, Young-Hoon, OK, Seon, PYO, Jae Sung, HWANG, Sung-Woo, AMATYA, Sarmila Shrestha, KIM, Bo Suel, KIM, Dong Hee, LEE, Sang Ho
Принадлежит:

The present invention relates to an Angelica gigas Nakai extract and, more specifically, to an Angelica gigas Nakai extract having effects of preventing a decrease in the number of white blood cells and restoring the number of white blood cells, containing decursin and decursinol angelate as active ingredients. Preferably, the Angelica gigas Nakai extract of the present invention contains 70 wt% or more of decursin and decursinol angelate.

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Номер записи: 4
09-07-2020 дата публикации

SELECTIVE EXTRACTION METHOD FOR NATURAL SUBSTANCES

Номер: WO2020141891A1
Автор: PYO, Jae Sung, KIM, Min Woo, PARK, Nam Kyu, LEE, Sung Mi
Принадлежит:

Disclosed is an extraction method for nonpolar natural substances. According to one embodiment of the present invention, the extraction method for nonpolar natural substances comprises: a step of conducting extraction of natural raw materials to prepare a first liquid extract; a step of mixing the first liquid extract with a phase separation composition containing a lipophilic solubilizer and water, and conducting a second extraction; and a step of isolating the supernatant of the phase-separated solution to obtain non-polar natural substances. Accordingly, by using a dissolution-emulsion extraction (DEE) method, the nonpolar natural substances can be extracted relatively easily with a high efficiency.

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Номер записи: 5
07-01-2019 дата публикации

바실러스 모자벤시스 케이제이에스-3 균주를 이용한 쿠에르세틴 추출물 제조방법

Номер: KR1020190001782A
Автор: 강재선, 권륜희, 김태후, 장나영, 정충기, 이진영, 표재성, 김강민
Принадлежит:

... 본 발명은, 바실러스 모자벤시스 케이제이에스-3 균주를 이용한 쿠에르세틴 추출물 및 그 제조방법에 있어서, 플라보노이드 성분을 포함하는 약초를 추출 및 현탁화하여 추출 원료를 형성하는 단계와; 바실러스 모자벤시스 케이제이에스-3 균주 배양액에 상기 추출 원료를 첨가하고, 42 내지 50℃의 온도에서 발효시켜 플라보노이드로부터 당이 제거된 쿠에르세틴을 포함하는 플라보노이드 활성형 용액을 제조하는 단계와; 상기 플라보노이드 활성형 용액을 농축하여 쿠에르세틴을 포함하는 농축물을 획득하는 단계를 포함하는 것을 기술적 요지로 한다. 이에 의해 생체 내로의 흡수나 생리활성 등의 면에서 우수한 효과를 나타내는 활성 플라보노이드를 보다 다량으로 생산하고, 고온 발효를 통해 플라보노이드에 붙어있는 당을 제거하여 활성형 성분인 쿠에르세틴을 다량 함유가능한 추출물을 얻을 수 있다.

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Номер записи: 6
15-02-2019 дата публикации

바실러스 모자벤시스 케이제이에스-3 균주를 이용한 쿠에르세틴 추출물 제조방법

Номер: KR0101948021B1
Автор: 강재선, 권륜희, 김태후, 장나영, 정충기, 이진영, 표재성, 김강민
Принадлежит: 경성대학교 산학협력단, 도린네이처 주식회사

... 본 발명은, 기탁번호 KCCM10961P로 특허기탁된 바실러스 모자벤시스 케이제이에스-3 균주를 이용한 쿠에르세틴 추출물 제조방법에 있어서, 플라보노이드 성분을 포함하는 약초를 추출 및 현탁화하여 추출 원료를 형성하는 단계와; 기탁번호 KCCM10961P로 특허기탁된 바실러스 모자벤시스 케이제이에스-3 균주 배양액에 추출 원료를 첨가하고, 42 내지 50℃의 온도에서 발효시켜 플라보노이드의 당 측쇄를 분해하여 플라보노이드로부터 당이 제거된 쿠에르세틴을 포함하는 플라보노이드 활성형 용액을 제조하는 단계와; 플라보노이드 활성형 용액을 농축하여 쿠에르세틴을 포함하는 농축물을 획득하는 단계를 포함하는 것을 기술적 요지로 한다. 이에 의해 생체 내로의 흡수나 생리활성 등의 면에서 우수한 효과를 나타내는 활성 플라보노이드를 보다 다량으로 생산하고, 고온 발효를 통해 플라보노이드에 붙어있는 당을 제거하여 활성형 성분인 쿠에르세틴을 다량 함유가능한 추출물을 얻을 수 있다.

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Номер записи: 7
19-06-2017 дата публикации

PYRAZINONE INDOLINONE DERIVATIVE FOR TREATMENT OF BREAST CANCER AND PREPARATION METHOD THEREOF

Номер: KR1020170068170A
Автор: KWAK, JAE HWAN, JUNG, YOUNG SUK, LEE, YUN HEE, PYO, JAE SUNG, BAEK, IN HWAN, KIM, YE JIN
Принадлежит:

The present invention relates to a novel pyrazinone indolinone derivative and a preparation method thereof. More specifically, the present invention relates to a novel pyrazinone indolinone compound for a target treatment agent for treating triple negative breast cancer obtained through a cyclization reaction, a substitution reaction of a benzyl group, and an amidation reaction using peptide-coupling and Mitsunobu reactions; and a preparation method thereof. The novel pyrazinone indolinone derivative of the present invention can be usefully used as a target treatment agent for treating intractable breast cancer, and specifically, has an effect of inhibiting the proliferation of MDA-MB-468 cells in which an epidermal growth factor receptor (EGFR) is overexpressed, similar to gefitinib known as an inhibitor of the EGFR. COPYRIGHT KIPO 2017 ...

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Номер записи: 8
26-09-2016 дата публикации

PHARMACEUTICAL COMPOSITION USEFUL FOR TREATING LEUKOPENIA INDUCED BY ADMINISTRATION OF ANTICANCER DRUGS, CONTAINING ANGELICA GIGAS NAKAI EXTRACT AS ACTIVE INGREDIENT

Номер: KR1020160111354A
Автор: KANG, JAE SEON, JI, YOUNG HOON, OK, SEON, PYO, JAE SUNG, HWANG, SUNG WOO, SARMILA SHRESTHA AMATYA, KIM, BO SUEL, KIM, DONG HEE, LEE, SANG HO
Принадлежит:

The present invention relates to a pharmaceutical composition which is useful for treating leukopenia induced by administration of anticancer drugs, containing an Angelica gigas Nakai extract as an active ingredient, wherein the content of decursin and decursinol angelate is 70-98% (w/w) by extracting Angelica gigas Nakai using ethanol. As shown in results derived from clinical tests and animal experiments, the composition exhibits effects of preventing reduction in the leucocyte count after anticancer treatment while restoring the reduced the leucocyte count. COPYRIGHT KIPO 2016 (AA) Number of white blood cells (BB) Normal group (CC) Control group (DD) Experimental group (EE) Recovery control group (FF) Recovery group ...

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Номер записи: 9
24-08-2018 дата публикации

유방암 치료를 위한 피라지노인돌론 유도체 약학적 조성물 및 이의 제조방법

Номер: KR0101891657B1
Автор: 곽재환, 정영석, 이윤희, 표재성, 백인환, 김예진
Принадлежит: 경성대학교 산학협력단

... 본 발명은 신규한 피라지노인돌론 유도체 약학적 조성물 및 이의 제조방법에 관한 것으로 구체적으로는 상기 신규 피라지노인돌 화합물은 펩타이드-커플링반응 및 미츠노부 반응을 이용한 고리화반응, 벤질 그룹의 치환반응과 아미데이션 반응을 통하여 삼중음성유방암 치료를 위한 표적치료제 및 이의 제조방법에 관한 것이다.본 발명의 신규 피라지노인돌론 유도체 화합물은 난치성 유방암 치료를 위한 표적치료제로써 유용하게 사용될 수 있고, 특히 기존 상피세포 성장인자 수용체(EGFR) 억제제로 알려진 제피티닙(gefitinib)과 유사하게 성장인자 수용체(EGFR)가 과발현된 MDA-MB-468 세포의 증식을 억제하는 효과가 있다.

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Номер записи: 10
17-03-2017 дата публикации

INJECTION OR EYE-DROP AGENT PRODUCED AS HOMOGENEOUS SOLUTION BY SOLUBILIZING POORLY SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENT, AND METHOD FOR PRODUCING SAME

Номер: KR101717672B1
Автор: KANG, JAE SEON, JUNG, CHUNG KI, LEE, SEO HYUN, KANG, JUN HO, CHOI, JAE KI, PYO, JAE SUNG
Принадлежит: KYUNGSUNG UNIVERSITY INDUSTRY COOPERATION FOUNDATION

The present invention provides an injection or an eye-drop agent produced as a homogeneous solution by solubilizing a poorly soluble active pharmaceutical ingredient. The injection or the eye-drop agent is produced by mixing a poorly soluble material which is dissolved in alcohol and is not dissolved in water; a detergent for dispersing the poorly soluble material; and a solubilizing agent for dissolving the poorly soluble material in a solvent (water). The poorly soluble material has an active pharmaceutical ingredient, and includes poorly soluble ginseng saponin (compound K molecular weight 622.878), dexamethasone (molecular weight 392.45), decursin (molecular weight 328.35), and decursinolangelate (molecular weight 328.35), which have molecular weights of 1000 or less, and cyclosporin (molecular weight 1202), which has a molecular weight of 2000 or less and has a cyclic structure therein. The solubilizing agent is used twice more than the poorly soluble material, and the poorly soluble ...

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Номер записи: 11
19-08-2015 дата публикации

PHARMACEUTICAL COMPOSITION USEFUL FOR SKIN REPRODUCTION

Номер: KR1020150094036A
Автор: KANG, JAE SEON, HA, SANG MIN, PYO, JAE SUNG
Принадлежит:

The present invention relates to a pharmaceutical composition and, more specifically, to a pharmaceutical composition useful for skin reproduction containing burnt alum, preferably, aluminum potassium sulfate as an active ingredient wherein the composition comprises hot water at 40-43°C added with 0.5-1 w/v% of burnt alum to be used in hot water treatment for skin reproduction. COPYRIGHT KIPO 2015 ...

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Номер записи: 12
29-01-2019 дата публикации

수용성 키토산과 아르기닌을 이용한 불용성 유효 약리성분의 균질 현탁용액제제 제조방법

Номер: KR1020190009650A
Автор: 강재선, 이진영, 정충기, 장나영, 김강민, 표재성, 최정숙
Принадлежит:

... 본 발명은, 수용성 키토산과 아르기닌을 이용한 불용성 유효 약리성분의 균질 현탁용액제제 및 그 제조방법에 있어서, 불용성이며 칼륨 흡착능력이 있는 원재료를 준비하는 단계, 상기 원재료에 아르기닌을 포함하는 현탁화제 및 수용성 키토산을 포함하는 분산제를 혼합하는 단계, 감미제를 혼합하는 단계로 이루어진 고체혼합물 준비단계와; 보존제를 알코올에 용해하는 단계, 상기 알코올에 정제수를 넣어 혼합하는 단계로 이루어진 액체혼합물 준비단계와; 상기 고체혼합물과 상기 액체혼합물을 혼합하고, 산도를 조절하는 단계로 이루어진 것을 기술적 요지로 한다. 이에 의해 본 발명의 균질 현탁용액제제는 불용성 약물인 원재료를 포함하는 제제를 수용성 키토산과 아르기닌을 통해 현탁 및 재현탁이 용이하며, 이로 인해 사용자의 복용 편리성과 순응도를 높일 수 있는 효과가 있다.

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Номер записи: 13