Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 38. Отображено 38.
18-04-2016 дата публикации

ORGANIC LIGHT EMITTING DISPLAY DEVICE AND METHOD FOR MANUFACTURING ORGANIC LIGHT EMITTING DISPLAY DEVICE

Номер: KR1020160041708A
Автор: LIM, HEE CHUL, SONG, EUN AH, BYUN, HYUN TAE, KIM, JUNG GI, HAN, GYU HYEONG
Принадлежит:

Provided are an organic light emitting device and a method of manufacturing an organic light emitting device. An organic light emitting device is disposed on a substrate. A sealing part is disposed to cover the organic light emitting device. The sealing part has a first inorganic sealing layer, an organic sealing layer on the first inorganic sealing layer, and a second inorganic sealing layer on the organic sealing layer. A barrier film faces the substrate. A pressurized adhesive layer is disposed between the sealing layer and the barrier film. The pressurized adhesive layer includes a first pressurized adhesive layer and a second pressurized adhesive layer. The second pressurized adhesive layer has a shape corresponding to at least a portion of an end of the organic sealing layer. The organic light emitting display device according to an embodiment of the present invention minimizes the generation of the space between the sealing part and the pressurized adhesive layer around the end of ...

Подробнее
Номер записи: 1
16-01-2019 дата публикации

동형 암호화된 데이터의 연산의 위변조를 판단하는 방법

Номер: KR1020190005540A
Автор: 천정희, 송용수, 한규형
Принадлежит:

... 본 발명에 의한 암호문 위변조 판단 방법이 수행되는 환경은, 기초 정보를 수집하는 정보 수집부와, 기초 정보를 암호화하는 암호화모듈과, 암호화 모듈의 결과값인 암호문을 수신하여 복호화하는 복호화 모듈과, 복호화된 데이터에 기반하여 제어되는 몸체부를 포함하는 시스템을 포함한다. 보안 인수( )에 따라 암호문의 집합(C)와 메시지의 집합(M)이 정해지며, 메시지 집합에서 암호문의 집합으로 보내는 비밀함수(s)로서 역함수가 존재하는 비밀함수(s)가 설정되며, 비밀키(K)가 정해진다. 본 발명에 의한 암호문 위변조 판단 방법은, 암호화 모듈이 메시지를 비밀함수(s)를 이용하여 암호문의 집합으로 보내는 인코딩을 수행하는 제1 단계와; 암호화 모듈이 메시지 각각에 부여되는 고유 번호(id)를, 비밀키(K)를 사용하는 의사 난수 함수(FK)에 의해 생성된 암호문의 집합(C)의 랜덤 원소에 대응시키는 제2 단계와; 암호화 모듈이 제1 단계에서 생성한 인코딩 메시지를 제2 단계에서 생성한 랜덤 원소를 이용하여 마스킹하여 암호화 값( )을 생성하는 제3 단계와; 복호화 모듈이 암호문의 위변조를 검증하는 제4 단계를 포함한다. 검증하는 제4 단계는, 메시지 각각의 고유 번호(id)를, 비밀키(K)를 사용하는 의사 난수 함수를 이용하여 암호문의 집합(C)의 랜덤 원소에 대응시키는 제4-1 단계와; 제4-1 단계에서 생성된 랜덤 원소를 이용하여 마스킹을 제거하는 제4-2 단계와; 비밀함수의 역함수를 이용하여 메시지를 복호화하는 제4-3 단계와; 제4-2 단계에서 마스킹을 제거하여 획득한 값이 비밀함수의 치역에 있는지 여부를 검증하고 참인 경우에만 제4-3 단계에서 복호화된 값을 출력하는 제4-4 단계를 포함한다.

Подробнее
Номер записи: 2
29-06-2015 дата публикации

PHARMACY COMPOSITE FOR TREATING ISCHEMIC STROKE INCLUDING CELL-PERMEABLE ATOX1 FUSION PROTEIN

Номер: KR1020150072113A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, CHO, YOON SHIN, UM, WON SIK, HWANG, IN KOO, KIM, DAE WON
Принадлежит:

The present invention relates to an antioxidant-1 (Atox1) which controls homeostasis of copper and is called as HAH1. The Atox1 has an antioxidant protection function for protecting cell from toxicity generated by superoxide anion and peroxide. But, a biological function of Atox1 in forebrain ischemic stroke is unknown. Inventors have found that Atox1 fusion protein has an ischemic stroke animal model protection effect in in vivo and a cell protection effect on the destruction of neuron due to oxidation stress in in vitro. The Atox1 fusion protein is efficiently permeated depending on concentrate and time into the neuron and increases a cell survival rate on the toxicity of peroxide. The Atox1 reduces DNA fragmentation due to the peroxide and activated oxygen in the cell and shows a protection effect on the destruction of the neuron caused when a temporary ischemia is caused at a CA1 part of forebrain hippocampus in an animal model. According to the results, the Atox1 fusion protein has ...

Подробнее
Номер записи: 3
12-10-2015 дата публикации

PHARMACEUTICAL COMPOSITION FOR PARKINSON′S DISEASE CONTAINING PON1 FUSION PROTEIN

Номер: KR1020150114107A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, UM, WON SIK, SHIN, MIN JEA, AHN, EUN HEE, CHO, SUNG WOO, KIM, DUK SOO, KWON, HYEOK YIL, KIM, DAE WON
Принадлежит:

The present inventors find that PEP-1-PON1 fusion proteins can protect dopaminergic neurons from oxidative stress in SH-SY5Y neuroblastoma cells and animal models of Parkinson′s disease. The PEP-1-PON1 fusion proteins are confirmed to be capable of easily moving into the SH-SY5Y neuroblastoma cells and substantia nigra of the brain. The PEP-1-PON1 fusion proteins can significantly suppress the generation of the reactive oxygen species induced by MPP+ and DNA fragmentation, thereby inducing the survival of SH-SY5Y cells consequently. The PEP-1-PON1 fusion proteins influence to the level of the pro-apoptotic mediator and the anti-self-apoptotic mediator to obtain the neuroprotective effects. Furthermore, TH antibodies and the immunohistochemical analysis data using the cresyl violet dye shows the PEP-1-PON1 fusion proteins can significantly protect the dopamine cells in the substantia nigra from the oxidative strees such as MPTP. Accordingly, the PEP-1-PON1 fusion proteins can be used for ...

Подробнее
Номер записи: 4
04-08-2017 дата публикации

PHARMACEUTICAL COMPOSITION FOR TREATING ISCHEMIC STROKE CONTAINING TXNL1 FUSION PROTEIN

Номер: KR101764583B1
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, UM, WON SIK, SHIN, MIN JEA, JO, HYO SANG, SOHN, EUN JEONG, SON, O RA, KIM, DUK SOO, KIM, DAE WON
Принадлежит: INDUSTRY ACADEMIC COOPERATION FOUNDATION, HALLYM UNIVERSITY

The present invention aims to provide medicines for treating ischemic stroke having or no side effects and having excellent effects. The present invention relates to a pharmaceutical composition for treating ischemic stroke containing cell permeable TXNL1 fusion protein, wherein the TXNL1 fusion protein penetrated into cells increased a cell survival rate to the hydrogen peroxide toxicity and decreased the intracellular reactive oxygen species level and hydrogen peroxide induced DNA fragmentation. In animal models, TXNL1 fusion protein showed a protective effect against neuronal cell death induced by transient ischemia in a CA1 region of the anterior hippocampus. The results suggest that the TXNL1 fusion protein has a protective effect against apoptosis and has a treating effect for protecting nerve cells from damage of ischemic stroke. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 5
06-01-2016 дата публикации

PHARMACEUTICAL COMPOSITION FOR TREATING ISCHEMIA CONTAINING CELL-TRANSDUCIBLE GSTpi FUSION PROTEIN

Номер: KR1020160000902A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, LEE, KEUN WOOK, UM, WON SIK, SOHN, EUN JEONG, CHO, SUNG WOO, KIM, DUK SOO, KIM, DAE WON
Принадлежит:

The present invention relates to a pharmaceutical composition comprising cell-transducible GSTpi fusion protein for treating ischemia. The GSTpi fusion protein penetrated into cells increases a cell survival rate for toxicity of hydrogen peroxide, and reduces level of active oxygen species in cells and DNA fragmentation induced by hydrogen peroxide. In an animal mode, the GSTpi fusion protein has a protection effect for neuron death caused by induction of temporary ischemia in a forebrain-hippocampus CA1 part. The results show that the GSTpi fusion protein has a protection effect for neuron death and has a treatment effect of protecting neurons from ischemia damages. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 6
16-08-2018 дата публикации

플렉서블 디스플레이 패널을 갖는 전자 디바이스

Номер: KR1020180091893A
Автор: 박희성, 한규형
Принадлежит:

... 뚜렷한 보더 사이즈를 감소시키고 그리고/또는 어셈블된 플렉서블 디스플레이의 측표면을 활용하기 위한 부분 또는 부분들의 벤딩을 허용하도록 구성된 복수의 혁신들을 갖는 플렉서블 디스플레이가 제공된다.

Подробнее
Номер записи: 7
01-02-2016 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING GADD45a FUSION PROTEIN FOR PREVENTING AND TREATING SKIN CANCER

Номер: KR1020160011257A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, KANG, TAE CHUN, KWON, HYUNG JOO, UM, WON SIK, SHIN, MIN JEA, AHN, EUN HEE, SON, O RA, PARK, MEE YOUNG, JANG, SANG HO, KIM, DAE WON
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a GADD45a fusion protein for preventing and treating skin cancer. The GADD45a fusion protein covalently bonded to a protein transport domain can significantly reduce the size and the number of cancer cells, by effectively penetrating to the cells. Therefore, the GADD45a fusion protein can be used for preventing and treating skin cancer. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 8
23-12-2015 дата публикации

POLARIZING FILM, MANUFACTURING METHOD OF SAME AND MANUFACTURING METHOD OF ORGANIC LIGHT EMITTING DISPLAY PANEL USING SAME

Номер: KR1020150142861A
Автор: BYUN, HYUN TAE, SONG, EUN AH, LIM, HEE CHUL, HAN, GYU HYEONG
Принадлежит:

The present invention relates to a manufacturing method of a touch electrode formed within the polarizing film constituting a display panel and a manufacturing method of an organic light emitting display panel by using the same. The manufacturing method of an organic light emitting display panel includes: a step for forming a panel comprising pixels which include an organic light emitting diode and a transistor driving the organic light emitting diode; a step for forming the polarizing film including a first functional film having a first touch electrode and a second functional film having a second touch electrode; a step for bonding the panel and the polarizing film; and a step for forming a cover plate for protecting the panel and the polarizing film. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 9
08-06-2017 дата публикации

POLARIZING FILM AND DISPLAY DEVICE INCLUDING SAME

Номер: KR1020170063309A
Автор: LIM, HEE CHUL, HAN, GYU HYEONG
Принадлежит:

According to the present invention, provided are a reflection prevention polarizing film and a display device including the same. The reflection prevention polarizing film includes a polarizing layer which linearly polarizes external light, a retardation layer which circularly polarizes light passing through the polarizing layer, a first support layer which is located between the polarizing layer and the retardation layer and protects the polarizing layer, and a second support layer which faces the first support layer with the polarizing layer interposed therebetween and protects the polarizing layer. A part of a specific layer facing the second support layer is extended toward an edge. Accordingly, the present invention can prevent damage to an adhesive material coated on the upper side of the edge of the specific layer. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 10
08-03-2017 дата публикации

ORGANIC LIGHT EMITTING DIODE DISPLAY AND MANUFACTURING METHOD THEREOF

Номер: KR1020170025653A
Автор: PARK, HEE SUNG, LIM, HEE CHUL, CHOI, WON YEOL, KIM, BYOUNG CHUL, HAN, GYU HYEONG
Принадлежит:

According to an embodiment of the present invention, provided is an organic light emitting diode display on which a heat diffusion pattern is arranged to minimize damage due to heat generated in a cutting process in a non-display region. A driving element and an organic light emitting element are arranged on a display region of a substrate on which the display region and the non-display region are defined. On an encapsulation substrate for protecting the organic light emitting element from oxygen and water, the heat diffusion pattern made of materials with high heat conductivity capable of diffusing heat is arranged on the non-display region, thereby minimizing damage due to heat generated in a scribe process using a laser. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 11
22-06-2018 дата публикации

ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITION CONTAINING CIAPIN1 FUSION PROTEIN

Номер: KR0101869686B1
Автор: CHOI, SU YOUNG, KIM, DAE WON, KIM, DUK SOO, UM, WON SIK, SHIN, MIN JEA, JO, HYO SANG, PARK, JIN SEO, HAN, KYU HYUNG, LEE, KEUN WOOK, CHO, SUNG WOO, PARK, JONG HOON, KWON, OH SHIN, SON, O RA, SOHN, EUN JEONG
Принадлежит: INDUSTRY ACADEMIC COOPERATION FOUNDATION, HALLYM UNIVERSITY

An objective of the present invention is to provide a medicine which has few or no side effects yet is highly efficacious in treating inflammation. The present invention relates to an anti-inflammatory pharmaceutical composition containing a cytokine induced apoptosis inhibitor 1 (CIAPIN1) fusion protein. The CIAPIN1 fusion protein permeated into cells depending on the dosage and treatment time, and the permeated CIAPIN1 fusion protein exhibited a noticeable level in the cells for 24 hours. Also, the CIAPIN1 fusion protein inhibited an LPS-induced inflammatory reaction and permeated into cells to alleviate an inflammation in LPS-treated cells to exhibit a cell protection effect. Moreover, the CIAPIN1 fusion protein impeded TPS-induced dermatophytes in an animal model to relieve a skin inflammation. It is indicated that the permeated Tat-CIAPIN1 fusion protein has a cell protection effect from apoptosis and an inflammation treating effect. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 12
05-03-2018 дата публикации

ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITION COMPRISING CELL-TRANSDUCIBLE ATOX1 FUSION PROTEIN

Номер: KR1020180021470A
Автор: CHOI, SU YOUNG, KIM, DAE WON, UM, WON SIK, SHIN, MIN JEA, JO, HYO SANG, KIM, DUK SOO, PARK, JIN SEO, HAN, KYU HYUNG, LEE, KEUN WOOK, CHO, YOON SHIN, SON, O RA, SOHN, EUN JEONG, KIM, HYUN AH
Принадлежит:

The object of the present invention is to provide an effective anti-inflammatory therapeutic agent with negligible or no side effects. To this end, the present invention provides an anti-inflammatory pharmaceutical composition comprising a cell-transducible ATOX1 fusion protein, in which the Atox1 fusion protein penetrated into a cell increased cell viability against the toxicity of hydrogen peroxide and reduced the level of active oxygen species, thereby providing cell protection. In addition, the Atox1 fusion protein significantly reduced the expression levels of LPS-induced COX2 and iNOS protein in a dose-dependent manner. In addition, a Tat-Atox1 fusion protein suppressed the inflammation response induced by high-concentration LPS. Further, the Tat-Atox1 fusion protein significantly inhibited the infiltration of inflammatory cells, such as monocytes, which occurs at an early stage of skin inflammation; significantly reduced the expression level of COX-2 and the production of TNF-α, ...

Подробнее
Номер записи: 13
07-07-2011 дата публикации

AUTOMATICALLY CONTROLLED OPERATING METHOD FOR A WIRELESS IMAGE-TRANSMITTING APPARATUS USING TRAIN OPERATING INFORMATION

Номер: KR2011081275A1
Автор: KIM, Bong Kyoung, HAN, Kyu Hyeong, KIM, Kyoung Taek, YOUK, Hae Un, CHA, Young Ju
Принадлежит:

The present invention relates to an automatically controlled operating method for a wireless image-transmitting apparatus using train operating information, and more particularly, to an automatically controlled operating method for a wireless image-transmitting apparatus using train operating information, wherein the method involves automatically outputting, to the onboard unit of a train, image data of train operating information at each train station the operating train enters, without any separate action by the conductor, whenever the train passes certain locations.

Подробнее
Номер записи: 14
23-09-2015 дата публикации

PHARMACEUTICAL COMPOSITION FOR TREATING CEREBRAL ISCHEMIA CONTAINING CELL-TRANSDUCIBLE PRAS40 FUSION PROTEIN

Номер: KR1020150106985A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, UM, WON SIK, HWANG, HYUN SOOK, CHO, YONG JUN, CHO, SUNG WOO, PARK, JONG HOON, PARK, EUN YOUNG, KIM, DAE WON
Принадлежит:

The present invention confirms that PRAS40 fusion proteins are effective in protecting nerve cells from cell death derived from oxidation stress in vitro and protecting animal models having cerebral ischemia in vivo. The PRAS40 fusion proteins are injected into nerve cells effectively depending on the concentration and time. The PRAS40 fusion proteins entering the cells increase a cell survival rate against the toxicity of hydrogen peroxide and reduce the DNA fragmentation induced by hydrogen peroxide and the level of reactive oxygen species in the cells. In animal models, the PRAS40 fusion proteins can prevent nerve cell death occurring when temporary ischemia is induced in a forebrain hippocampal CA1 area. The results propose that the PRAS40 fusion proteins have a protection effect against cell death and is effective in protecting nerve cells from cerebral ischemic damage. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 15
01-12-2016 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING DIABETES CONTAINING CELL-TRANSDUCIBLE DJ-1 FUSION PROTEIN

Номер: KR1020160137760A
Автор: CHOI, SU YOUNG, UM, WON SIK, PARK, JIN SEO, HAN, KYU HYUNG, CHO, YOON SHIN, LEE, KEUN WOOK, SHIN, MIN JEA, KWON, HYEOK YIL, KIM, DAE WON
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating diabetes and, more specifically, to a pharmaceutical composition for preventing or treating diabetes containing tissue and cell-transducible DJ-1 fusion protein as an active ingredient. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 16
10-06-2016 дата публикации

ORGANIC LIGHT EMITTING DISPLAY DEVICE AND METHOD FOR MANUFACTURING SAME

Номер: KR1020160066369A
Автор: LIM, HEE CHUL, SONG, EUN AH, BYUN, HYUN TAE, HAN, GYU HYEONG
Принадлежит:

Provided are an organic light emitting display device and a method for manufacturing the same. An organic light emitting device is arranged on a flexible substrate of the organic light emitting display device. A sealing layer is arranged to cover the organic light emitting device in order to protect the organic light emitting device. A barrier film is provided opposite to a flexible substrate. A pressure adhesive layer is arranged between the sealing layer and the barrier film. At least one of the upper and bottom sides of a pressure adhesive layer includes an uneven surface. In the organic light emitting display device according to an embodiment of the present invention, at least one of the upper and bottom sides of a pressure adhesive layer includes an uneven surface, the adhesive area between a pressure adhesive layer and a barrier film and/or the adhesive area between a pressure adhesive layer and a sealing layer can be increased. Accordingly, the adhesive strength between a pressure ...

Подробнее
Номер записи: 17
20-06-2019 дата публикации

TERMINAL DEVICE FOR PERFORMING HOMOMORPHIC ENCRYPTION, SERVER DEVICE FOR PROCESSING CIPHER TEXT THEREOF, AND METHODS THEREFOR

Номер: WO2019117694A1
Автор: CHEON, Jung Hee, KIM, Duhyeong, SONG, Yongsoo, HAN, Kyoohyung
Принадлежит:

Disclosed is an encryption method. According to the present method, a homomorphic cipher text can be generated by using a public key after reflecting a scaling factor to a message. The generated cipher text is generated in the form in which a result value is restored when decrypted, wherein the result value is a value in which an error value is added to a value in which the scaling factor is reflected to the message. Accordingly, it is possible to effectively generate a homomorphic cipher text which can be operated in an encrypted state.

Подробнее
Номер записи: 18
27-04-2016 дата публикации

PHARMACEUTICAL COMPOSITION FOR TREATING CEREBRAL ISCHEMIA, CONTAINING GLUTAREDOXIN FUSION PROTEIN

Номер: KR1020160045160A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, CHO, YOON SHIN, LEE, KEUN WOOK, UM, WON SIK, KIM, DUK SOO, CHO, SUNG WOO, KWON, OH SHIN, KIM, DAE WON
Принадлежит:

The present invention relates to a pharmaceutical composition for treating cerebral ischemia, containing a cell-permeable glutaredoxin (GLRX) fusion protein. The GLRX fusion protein penetrated into cells increases the cell survival rate under the toxicity of hydrogen peroxide, while reducing the DNA fragmentation induced by hydrogen peroxide and the level of intracellular active oxygen species. In an animal model, the GLRX fusion protein of the present invention has shown protective effects with respect to neuronal cell death taking place after induction of temporary ischemia on a region of hippocampal CA1 in the forebrain. Such results indicate that the GLRX fusion protein has protective effects on the cell death and treating effects by protecting neural cells from the ischemia damage. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 19
06-07-2018 дата публикации

DISPLAY DEVICE AND MANUFACTURING METHOD THEREOF

Номер: KR1020180076590A
Автор: HAN, GYU HYEONG, LIM, HEE CHUL, KIM, BYOUNG CHUL, PARK, HEE SUNG
Принадлежит:

The present invention provides a display device in which a cathode electrode is not torn from an organic light emitting layer and a manufacturing method thereof. According to one embodiment of the present invention, the manufacturing method of the display device comprises the following steps: forming pixels in a display region on a substrate; forming an encapsulation film to cover the display region; attaching a protective film on the encapsulation film; and removing the protective film. At this time, the protective film includes a base layer and a first adhesive layer formed on at least one edge region of the base layer. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 20
16-02-2017 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ISCHEMIC STROKE CONTAINING CELL-PERMEABLE HEAT-SHOCK PROTEIN 22 FUSION PROTEIN

Номер: KR1020170018225A
Автор: CHOI, SU YOUNG, CHO, YONG JUN, PARK, JIN SEO, HAN, KYU HYUNG, CHO, YOON SHIN, LEE, KEUN WOOK, JO, HYO SANG, UM, WON SIK, SHIN, MIN JEA, CHO, SUNG WOO, KIM, DUK SOO, KIM, DAE WON
Принадлежит:

The present invention relates to a pharmaceutical composition for treating ischemic stroke which comprises a cell-permeable heat-shock protein 22 fusion protein, and the heat shock protein 22 fusion protein transmitted into cells has increased cell viability against hydrogen peroxide toxicity and reduced DNA fragmentation, which is derived from an active oxygen species level and hydrogen peroxide in a cell. The animal model showed a protective effect of the fusion protein of the heat-shock protein 22 fusion protein against nerve cell death caused by transient ischemia in a part of the forebrain hippocampus CA1. These results indicate that the heat-shock protein 22 fusion protein is protected against apoptosis and has a therapeutic effect for protecting neural cells from ischemic damage. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 21
29-03-2017 дата публикации

DISPLAY DEVICE

Номер: KR1020170034617A
Автор: LIM, HEE CHUL, HAN, GYU HYEONG
Принадлежит:

The present invention relates to an organic light emitting display device. The organic light emitting display device comprises: an organic light emitting device layer disposed on a substrate; and an encapsulation layer configured to cover the organic light emitting device layer to block moisture or oxygen from penetrating. The encapsulation layer includes a barrier film having a transmittance control layer through which a ratio of passing light, emitted from the organic light emitting device layer, toward the outside can be controlled. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 22
18-11-2015 дата публикации

ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITION CONTAINING CELL-PENETRATING CARBONYL REDUCTASE FUSION PROTEIN

Номер: KR1020150127881A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, KWON, HYEOK YIL, UM, WON SIK, KIM, DUK SOO, PARK, JONG HOON, PARK, EUN YOUNG, KIM, HYUN AH, KIM, DAE WON
Принадлежит:

The human carbonyl group reductase 1 (CBR1) is a member of the NADPH-dependent short chain dehydratase/reductase superfamily, and the family is known to perform an important role in nerve cells through an antioxidative function. According to the present invention, a cell-penetrating Tat-CBR1 fusion protein is manufactured and whether the fusion protein has a protective effect against inflammation in LPS- or hydrogen peroxide-treated Raw 264.7 cells and TPA-treated skin inflammation animal models is tested. As a result, the Tat-CBR1 fusion protein effectively penetrates into the Raw 264.7 cells and had a significant cell protective effect on LPS- or hydrogen peroxide-induced inflammation and apoptosis. In addition, the locally applied Tat-CBR1 fusion protein induces a remarkable alleviative effect on TPA (12-O-tetradecanoylphorbol-13-acetate)-induced ear edema, and it was revealed the Tat-CBR1 fusion protein can be used as a therapeutic agent for various inflammation and oxidative stress-related ...

Подробнее
Номер записи: 23
02-11-2015 дата публикации

PHARMACEUTICAL COMPOSITION FOR TREATING ISCHEMIA, CONTAINING CELL-PENETRATING NOL3 FUSION PROTEIN

Номер: KR1020150122280A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, CHO, YOON SHIN, UM, WON SIK, CHO, SUNG WOO, PARK, JONG HOON, PARK, EUN YOUNG, KIM, DUK SOO, KIM, DAE WON
Принадлежит:

The present inventors revealed that a NOL3 fusion protein has a cell protective effect on oxidative stress-induced neural cell apoptosis in vitro and a protective effect on ischemia animal models in vivo. The NOL3 fusion protein effectively penetrated into neural cells in a concentration- and time-dependent manner. The NOL3 fusion protein penetrated into the cells increased cell viability against the toxicity of hydrogen peroxide, and decreased the level of reactive oxygen species in the cells and DNA fragmentation induced by hydrogen peroxide. In animal models, the NOL3 fusion protein showed a protective effect on neural cell apoptosis caused in the case of inducing temporary ischemia at a CA1 section of hippocampus in forebrain. These results indicate that the NOL3 fusion protein has protective effects on cell apoptosis and therapeutic effects for protecting the neural cells from ischemic brain injury. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 24
06-07-2018 дата публикации

DISPLAY DEVICE AND MANUFACTURING METHOD THEREOF

Номер: KR1020180076496A
Автор: KIM, TAE KYUNG, LIM, HEE CHUL, KANG, MOO CHAN, HAN, GYU HYEONG, SON, JUNG WON
Принадлежит:

The present invention provide a display device capable of preventing moisture from penetrating into a bank and a manufacturing method thereof. The display device according to one embodiment of the present invention comprises a plurality of pixels arranged on a substrate; a bank dividing a plurality of pixels; a blocking film disposed on the bank and comprising a plurality of patterns; and a spacer arranged to overlap the blocking film on the blocking film. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 25
19-04-2016 дата публикации

PHARMACEUTICAL COMPOSITION FOR TREATING CEREBRAL ISCHEMIA, CONTAINING CELL PERMEABLE PHOSPHOPROTEIN ENRICHED IN ASTROCYTES 15 FUSION PROTEIN

Номер: KR1020160042214A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, LEE, KEUN WOOK, UM, WON SIK, KIM, DUK SOO, CHO, SUNG WOO, KWON, OH SHIN, KIM, DAE WON
Принадлежит:

The present invention relates to a pharmaceutical composition for treating cerebral ischemia, containing a cell-permeable phosphoprotein enriched in astrocytes 15 (PEA15) fusion protein. The PEA15 fusion protein penetrated into cells increases cell survival rate under the toxicity of hydrogen peroxide, while reducing the DNA fragmentation induced by hydrogen peroxide and the level of intracellular active oxygen species. In an animal model, the PEA15 fusion protein of the present invention has shown protective effects with respect to neuronal cell death taking place by induction of temporary ischemia on a region of hippocampal CA1 in the forebrain. Such results indicate that the PEA15 fusion protein has protective effects from the cell death and treating effects by protecting neural cells from the ischemia damage. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 26
25-11-2015 дата публикации

ORGANIC LIGHT EMITTING DISPLAY DEVICE AND METHOD FOR MANUFACTURING SAME

Номер: KR1020150131524A
Автор: BYUN, HYUN TAE, SONG, EUN AH, LIM, HEE CHUL, HAN, GYU HYEONG
Принадлежит:

An organic light emitting display device according to an embodiment of the present invention includes an organic light emitting unit formed on a first substrate, an encapsulation unit which covers the organic light emitting unit, and a second substrate formed on the encapsulation unit. In addition, a sealing unit is disposed between the first substrate and the second substrate. The sealing unit comprises a first portion which covers the organic light emitting unit, a second portion which is placed apart from the first portion, and a third portion which is located between the first portion and the second portion and includes inert gas. The organic light emitting display device according to an embodiment of the present invention includes the sealing unit which is divided into at least three portions. Therefore, moisture penetration from peripheral sides can be delayed, various types of defects can be ameliorated, and a lifespan of the organic light emitting display device can be prolonged ...

Подробнее
Номер записи: 27
30-10-2015 дата публикации

PHARMACEUTICAL COMPOSOTION FOR TREATING ISCHEMIC STROKE CONTAINING CELL-PERMEABLE PIM2 FUSION PROTEIN

Номер: KR1020150121754A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, UM, WON SIK, CHO, YONG JUN, CHO, SUNG WOO, KIM, DAE WON
Принадлежит:

The biological functionality of the brain ischemia is not surely known PIM2 as a type of kinase, having an important role in cell survival. The present inventors study the protective effect of PIM2 fusion protein on the cell death and ischemia induced by oxidative stress. As a result, a purified Tat-PIM2 fusion protein is transmitted to the time, concentration-dependent manner within the hippocampus HT22 cells, has n protective effect on the cell death caused by oxidative stress. In addition, the transmission Tat-PIM2 fusion protein exhibits a protective effect on DNA fragmentation. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 28
07-04-2022 дата публикации

PROTEIN TRANSDUCTION DOMAIN, FUSION COMPOUND INCLUDING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FUSION COMPOUND

Номер: WO2022071771A1
Автор: CHOI, Soo-Young, PARK, Jin-Seu, HAN, Kyuhyung, LEE, Keunwook, PARK, Jong Kook, EUM, Won Sik, SHIN, Min Jea, LEE, Sung Ho, LEE, Sunghou, YEO, Hyeon Ji, YEO, Eun Ji, CHOI, Yeon Joo, SOHN, Eun Jeong, CHA, Hyun Ju, KWON, Hyun Jung, KIM, Dae Won
Принадлежит:

The subject to be achieved by the present invention is to provide a more effective, novel protein transduction domain and a fusion compound. In order to achieve the subject, the present inventors had selected and tested many candidate peptides, resulting in the finding that the GK peptide consisting of 18 amino acids and modified sequences having some sequences substituted, added, or deleted on the peptide as a base sequence can bind to polymers such as proteins and smoothly penetrate the polymers into biological entities such as cells, tissues, blood, etc. Therefore, a fusion compound, an oligonucleotide, or a vector, each using GK peptide or a variant thereof, can be applied to a pharmaceutical composition for prevention or treatment of a disease.

Подробнее
Номер записи: 29
10-07-2017 дата публикации

POLARIZING FILM AND ORGANIC LIGHT EMITTING DISPLAY APPARATUS

Номер: KR1020170080296A
Автор: HAN, GYU HYEONG, LIM, HEE CHUL
Принадлежит:

Provided are a polarizing film and an organic light emitting display apparatus. The polarizing film according to an embodiment of the present invention comprises: a first protective film; a first adhesive layer on the first protective film; at least one polarizing member on the first adhesive layer; a second adhesive layer on the polarizing member; and a second protective film on the second adhesive layer. The second adhesive layer can have a plurality of first parts made of an adhesive material; and a second part between a plurality of first parts, which is physically separated from the plurality of first parts. Therefore, the polarizing film can prevent defects due to foreign materials on a second adhesive layer when the polarizing film is individualized to the organic light emitting apparatus after being disposed on a motherboard for manufacturing the organic light emitting apparatus. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 30
06-01-2017 дата публикации

ORGANIC LIGHT EMITTING DIODE DISPLAY DEVICE AND MANUFACTURING METHOD THEREOF

Номер: KR1020170002148A
Автор: PARK, HEE SUNG, LIM, HEE CHUL, CHOI, WON YEOL, HAN, GYU HYEONG
Принадлежит:

According to an embodiment of the present invention, provided is an organic light emitting diode display device including a display region and a non-display region defined on a substrate and a structure for controlling an arrangement region of an encapsulation layer covering an organic light emitting element. A driving element and the organic light emitting element are arranged on the substrate and the encapsulation layer is arranged to cover the organic light emitting element. The reliability of the organic light emitting diode display device can be improved by controlling the arrangement region of the encapsulation layer by including the structure on the non-display region for controlling the arrangement region of the encapsulation layer in an encapsulation layer arranging process and preventing a lifting phenomenon of a mask to be used in the encapsulation layer arranging process. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 31
27-07-2017 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING ARTHRITIS CONTAINING PEA15 FUSION PROTEIN

Номер: KR101761550B1
Автор: CHOI, SU YOUNG, KIM, DAE WON, UM, WON SIK, SHIN, MIN JEA, SOHN, EUN JEONG, SON, O RA, PARK, JIN SEO, HAN, KYU HYUNG, CHO, SUNG WOO, KIM, HYUN AH, HWANG, HYUN SOOK
Принадлежит: INDUSTRY ACADEMIC COOPERATION FOUNDATION, HALLYM UNIVERSITY

The purpose of the present invention is to provide a pharmaceutical composition which easily permeates cells and is effective for inflammatory arthritis. The present invention relates to a pharmaceutical composition for preventing and treating arthritis containing PEA15 fusion protein which can permeate cartilage tissue as an active ingredient. The composition reduces expression levels of protein and mRNA of an inflammation marker and inflammatory cytokine in inflammation induction cartridge cells. Accordingly, PEP-1-PEA15 fusion protein is useful as a pharmaceutical composition for preventing and treating inflammatory arthritis. COPYRIGHT KIPO 2017 ...

Подробнее
Номер записи: 32
16-03-2017 дата публикации

PHARMACEUTICAL COMPOSITION INCLUDING CELL PENETRABLE PRAS40 FUSION PROTEIN FOR PREVENTING AND TREATING PARKINSON′S DISEASE

Номер: KR1020170029672A
Автор: CHOI, SU YOUNG, SHIN, MIN JEA, KIM, DAE WON, UM, WON SIK, PARK, JIN SEO, HAN, KYU HYUNG, LEE, KEUN WOOK, CHO, YOON SHIN, KIM, DUK SOO, CHO, SUNG WOO, KIM, JOON
Принадлежит:

The Parkinson′s disease is a neurodegenerative disease in which dopamine neurons are gradually removed from the substantia nigra of the brain. The inventors have clarified that a PRAS40 fusion protein can protect dopamine neurons from oxidation stress in SH-SY5Y neuroblastoma cells and Parkinson′s disease animal models. The PRAS40 fusion protein has been confirmed to be able to smoothly move into SH-SY5Y cells and into the substantia nigra of the brain through a Western blot analysis. The PRAS40 fusion protein remarkably inhibits DNA fragment and production of active oxygen species induced by MPP^+, and the survival of SH-SY5Y cells is eventually induced. In addition, immunohistochemical analyzing data using TH antibody and cresyl violet coloration shows that the PRAS40 fusion protein remarkably protects dopamine cells in the substantia nigra with respect to oxidation stress such as MPTP. Accordingly, the PRAS40 fusion protein can be used in preventing and treating the Parkinson′s disease ...

Подробнее
Номер записи: 33
03-09-2015 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING PRAS40 FUSION PROTEIN FOR PREVENTING AND TREATING POLYCYSTIC KIDNEY DISEASE

Номер: KR1020150101098A
Автор: CHOI, SU YOUNG, PARK, JIN SEO, HAN, KYU HYUNG, UM, WON SIK, CHO, SUNG WOO, PARK, JONG HOON, PARK, EUN YOUNG, KIM, DAE WON
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating an autosomal dominant polycystic kidney disease and, more specifically, to a pharmaceutical composition for preventing or treating a polycystic kidney disease comprising, as an active ingredient, a PRAS40 fusion protein capable of penetrating into polycystic kidney disease cells. COPYRIGHT KIPO 2015 ...

Подробнее
Номер записи: 34
30-01-2020 дата публикации

APPARATUS AND METHOD FOR PERFORMING APPROXIMATION CALCULATION ON CRYPTOGRAMS

Номер: WO2020022598A1
Автор: CHEON, Jung Hee, SONG, Yongsoo, KIM, Andrey, KIM, Miran, HAN, Kyoohyung
Принадлежит:

A calculating apparatus and method for processing homomorphic cryptograms are disclosed. The method includes the steps of: calculating an approximate polynomial corresponding to a calculation function to be applied to homomorphic cryptograms; and approximating the homomorphic cryptograms by using the approximate polynomial. Accordingly, the present invention can perform more efficient processing of cryptograms.

Подробнее
Номер записи: 35
10-05-2018 дата публикации

DISPLAY DEVICE AND METHOD FOR MANUFACTURING SAME

Номер: KR1020180047281A
Автор: KIM, BYOUNG CHUL, HUH, HAE RI, HAN, GYU HYEONG
Принадлежит:

The present invention provides a display device capable of mitigating the taper angle of a dam and a method of manufacturing the same. The display device according to an embodiment of the present invention includes a substrate including a display region where pixels are arranged and a non-display region surrounding the display region, an encapsulating film covering the display region and including at least one inorganic film and the first organic film, a first dam disposed in the non-display region and having the first organic film arranged therein, and a second organic film disposed outside the first dam. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 36
26-11-2015 дата публикации

ORGANIC LIGHT EMITTING DISPLAY DEVICE AND METHOD FOR MANUFACTURING SAME

Номер: KR1020150132722A
Автор: SONG, EUN AH, LIM, HEE CHUL, BYUN, HYUN TAE, HAN, GYU HYEONG
Принадлежит:

An organic light emitting display device according to an embodiment of the present invention comprises an organic light emitting part disposed on a substrate, and a sealing part which seals the organic light emitting part. Also, the organic light emitting display device comprises a cover part formed on the sealing part, and an attaching part formed between the sealing part and the cover part. The attaching part has an absorption region and a transmission region. The organic light emitting display device according to an embodiment of the present invention has multiple additives formed only in the absorption region of the attaching part. Therefore, the organic light emitting display device can have improved visibility and brightness due to external light without a polarizing plate, and can be flexibly bent. COPYRIGHT KIPO 2016 ...

Подробнее
Номер записи: 37
07-06-2018 дата публикации

DISPLAY DEVICE

Номер: KR1020180060676A
Автор: LIM, HEE CHUL, HAN, GYU HYEONG
Принадлежит:

The present invention provides a display device capable of preventing a crack from occurring in the edge region of a substrate. The display device according to an embodiment of the present invention includes a first substrate including a display region in which pixels are arranged and a non-display region surrounding the display region, a second substrate disposed on the first substrate and having a smaller area than the first substrate while covering the display region of the first substrate, a first adhesive layer disposed between the first substrate and the second substrate, and a protective film disposed on the edge of the first substrate and being in contact with the side surface of the first adhesive layer. COPYRIGHT KIPO 2018 ...

Подробнее
Номер записи: 38