21-09-2017 дата публикации
Номер: WO2017160069A1
Автор:
KIM, Sunghoon,
HAN, Gyoonhee,
YANG, Jee Sun,
LEE, Chulho,
KIM, Jae Hyun,
JUNG, Kilsoo,
HAN, Jung Min,
KIM, Jong Hyun
Принадлежит:
The present invention relates to a novel benzenesulfonamide derivative or a pharmaceutically acceptable salt thereof and a use thereof and, more specifically, to a novel benzenesulfonamide derivative having a mammalian target of rapamycin complex 1 (mTORC1) inhibitory effect and to a pharmaceutical composition containing the same as an active ingredient. The benzenesulfonamide derivative of chemical formula 1 according to the present invention is very highly effective in inhibiting the activation of mTORC1 through the inhibition of the binding between LRS and RagD, and thus the benzenesulfonamide derivative is very favorably utilized in the development of a prophylactic or therapeutic agent for any one disease selected from the group consisting of cancer, epilepsy, inflammatory diseases, immune diseases, diabetes, obesity, respiratory obstructive diseases, fibrosis, Pompe's disease, lysosomal storage disease, neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease, ...
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