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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 10. Отображено 10.
04-01-2012 дата публикации

Application of 23-HBA for preparing drug to reduce cardiotoxicity caused by adriamycin

Номер: CN0101961339B
Автор: WANG GUANGJI, HAO GANG, ZHOU FANG, WU XIAOLAN, ZHENG YUANTING, YE WENCAI, ZHU XUANXUAN, A JIYE, ZHANG JINGWEI, LIU LINSHENG, ZHANG XIAOXUAN, ZHOU YING, SUN YUAN, LUO DAN, JI WEI, GUANGJI WANG, GANG HAO, FANG ZHOU, XIAOLAN WU, YUANTING ZHENG, WENCAI YE, XUANXUAN ZHU, JIYE A, JINGWEI ZHANG, LINSHENG LIU, XIAOXUAN ZHANG, YING ZHOU, YUAN SUN, DAN LUO, WEI JI
Принадлежит:

The invention relates to the field of natural drugs, in particular to the application of 23-hydroxybetulinic acid (23-HBA) for preparing a drug to reduce cardiotoxicity caused by adriamycin. When being combined with adriamycin, the 23-hydroxybetulinic acid can reduce the consistency of the adriamycin in heart tissues of tumor mice, reverse eardiotoxieity caused by the adriamycin and improve cardiac function, thereby being capable of being used as a myocardial protecting agent of the adriamycin as an antitumor drug.

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Номер записи: 1
11-08-2010 дата публикации

Method for quantitative evaluation of drug effect by applying metabonomic technology

Номер: CN0101799462A
Автор: A JIYE, CAO BEI, ZHA WEIBIN, GONG PING, GU SHENGHUA, HUANG QING, LI MENGJIE, LIU LINSHENG, LU YIHONG, SHI JIAN, WANG GUANGJI, WANG XINWEN, YAN BEI, ZHANG YING, ZHAO CHUNYAN, ZHENG TIAN, JIYE A, BEI CAO, WEIBIN ZHA, PING GONG, SHENGHUA GU, QING HUANG, MENGJIE LI, LINSHENG LIU, YIHONG LU, JIAN SHI, GUANGJI WANG, XINWEN WANG, BEI YAN, YING ZHANG, CHUNYAN ZHAO, TIAN ZHENG
Принадлежит:

The invention discloses a method for quantitative evaluation of drug effect by applying the metabonomic technology. The method is characterized by comprising the following steps: measuring small-molecule compounds in a biological sample in an overall and quantified manner by using the metabonomic method based on mass spectrometry, nuclear magnetic resonance and other measurement technologies; and further establishing a multi-dimensional space mathematical model by using the multi-variable data processing method, to calculate the relative distance between an administration group and a control group as the quantified index for evaluating the drug effect, thus solving the difficult problem that the quantified evaluation index is not available to the evaluation for the drug effect of various drugs. Compared with the conventional method for evaluating the drug effect, the method of the invention has the advantages of wide applicable range, high sensitivity and convenient sampling process, prevents ...

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Номер записи: 2
16-07-2014 дата публикации

Application of 9-demethylberberine in preparation of hpyerglycemic drug

Номер: CN103919775A
Автор: WANG GUANGJI, A JIYE, YU XIAOYI, SUN RUNBIN, MAO YONG, FENG SIQI, XIAO WENJING
Принадлежит:

The invention provides a hypoglycemic compound 9-demethylberberine. The 9-demethylberberine is derived from a main in-vivo metabolite of natural medicine berberine, and is also named as berberrubine. The researches on animal models with hyperglycemia find that the 9-demethylberberine has good hpyerglycemic effect and has no obvious side effects for 6 weeks of continuous medication. The discovery can lead to discovery of a new hypoglycemic drug, and provides another alternative medicine for clinic treatment of diabetes and related diseases.

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Номер записи: 3
02-02-2011 дата публикации

Application of 23-HBA for preparing drug to reduce cardiotoxicity caused by adriamycin

Номер: CN0101961339A
Автор: GUANGJI WANG, GANG HAO, FANG ZHOU, XIAOLAN WU, YUANTING ZHENG, WENCAI YE, XUANXUAN ZHU, JIYE A, JINGWEI ZHANG, LINSHENG LIU, XIAOXUAN ZHANG, YING ZHOU, YUAN SUN, DAN LUO, WEI JI, WANG GUANGJI, HAO GANG, ZHOU FANG, WU XIAOLAN, ZHENG YUANTING, YE WENCAI, ZHU XUANXUAN, A JIYE, ZHANG JINGWEI, LIU LINSHENG, ZHANG XIAOXUAN, ZHOU YING, SUN YUAN, LUO DAN, JI WEI
Принадлежит:

The invention relates to the field of natural drugs, in particular to the application of 23-hydroxybetulinic acid (23-HBA) for preparing a drug to reduce cardiotoxicity caused by adriamycin. When being combined with adriamycin, the 23-hydroxybetulinic acid can reduce the consistency of the adriamycin in heart tissues of tumor mice, reverse eardiotoxieity caused by the adriamycin and improve cardiac function, thereby being capable of being used as a myocardial protecting agent of the adriamycin as an antitumor drug.

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Номер записи: 4
16-07-2014 дата публикации

Application of 9-demethylberberine in preparation of hypolipidemic drug

Номер: CN103919773A
Автор: A JIYE, WANG GUANGJI, SUN RUNBIN, GE CHUN, YANG NA, YU XIAOYI, XIAO WENJING
Принадлежит:

The invention provides a hypolipidemic compound 9-demethylberberine. The 9-demethylberberine is derived from a main in-vivo metabolite of natural medicine berberine, and is also named as berberrubine. The researches on model animals with hyperlipidemia find that the 9-demethylberberine has good drug effects of reducing cholesterol, triglyceride, low density lipoprotein (LDL) and the like, and has no obvious side effects for 6 weeks of continuous medication. The discovery can lead to discovery of a new hypolipidemic drug, and provides another alternative medicine for clinic treatment of hyperlipidemia, lipid metabolism disorder and high fat and obese patients and related people wanting to lose weight.

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Номер записи: 5
26-02-2014 дата публикации

Method for measuring serum metabolism markers in methylamphetamine abusers

Номер: CN103604875A
Автор: WANG GUANGJI, A JIYE, ZHENG TIAN, ZHOU YAHONG, LIU LINSHENG
Принадлежит:

The invention discloses a method for measuring serum metabolism markers in methylamphetamine abusers. The method mainly utilizes technologies and methods based on gas chromatography mass spectrum (GC-MS) and liquid chromatography mass spectrum (LC-MS) to quantitatively measure the endogenous small molecular compounds in methylamphetamine abusers' blood, then calculates and compares the relative concentration difference of the endogenous small molecular compounds between an abuser group and a normal group, and is used for actual diagnosis of abuse level of methylamphetamine. Compared to other conventional clinical diagnosis indexes, the method has the advantages of wide application area, high sensitivity, convenient sampling, simple operation, and no harm to organisms. The method solves the problem of shortage of clinical indexes for methylamphetamine abusers, and improves the efficiency of detecting methylamphetamine abusers.

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Номер записи: 6
20-08-2014 дата публикации

Use of demethyleneberberine in preparation of blood sugar-reduction drug

Номер: CN103989677A
Автор: A JIYE, WANG GUANGJI, XIAO WENJING, SUN RUNBIN, XIA WENJUAN, WANG PEI, YU XIAOYI
Принадлежит:

The invention provides a compound having a blood sugar-reduction effect, and the compound is demethyleneberberine. Demethyleneberberine is extracted from an in-vivo metabolite of natural drug berberine. A hyperglycemia model animal research shows that demethyleneberberine has good blood sugar-reduction effects, and after continuous administration for six weeks, obvious toxic or side effect is not produced. Through discovery of the use, a novel blood sugar-reduction drug can be produced and provides an optional drug for clinical treatment on diabetes and related diseases.

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Номер записи: 7
13-08-2014 дата публикации

Hypoglycemic compound sustained-release capsule and preparation method thereof

Номер: CN103976997A
Автор: YIN LIFANG, WANG GUANGJI, ZHOU CHUNYAN, SUN HONGBIN, ZHU CHUNLI, A JIYE, QIN CHAO, DI BIN, ZHU PANPAN, CAO LIN
Принадлежит:

The invention relates to a compound hypoglycemic sustained-release pellet and a preparation method thereof, and aims to integrate two drugs with different physical and chemical properties and different in-vivo pharmaceutical kinetic speeds into a pellet preparation with different drug release speeds. The preparation method of the capsule comprises the following steps: individually preparing a metformin hydrochloride composition sustained-release pellet and a saxagliptin sustained-release pellet, mixing the two pellets according to a certain ratio, and finally loading the mixed material into a capsule so as to obtain the hypoglycemic capsule. The two oral hypoglycemic drugs can cooperate with each other to generate a synergic effect, and the two drugs are made into a compound sustained-release preparation, so the preparation has a dual-advantage of a sustained-release preparation and a compound preparation, and can be used for the type-II diabetes patients who must use the metformin hydrochloride ...

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Номер записи: 8
25-08-2010 дата публикации

Method for quantitatively evaluating medicament toxicity by using metabonomic technology

Номер: CN0101813680A
Автор: A JIYE, CAO BEI, ZHA WEIBIN, GONG PING, GU SHENGHUA, HUANG QING, LI MENGJIE, LIU LINSHENG, SHAO FENG, SHI JIAN, WANG GUANGJI, WANG XINWEN, YAN BEI, ZHANG YING, ZHAO CHUNYAN, ZHENG TIAN, JIYE A, BEI CAO, WEIBIN ZHA, PING GONG, SHENGHUA GU, QING HUANG, MENGJIE LI, LINSHENG LIU, FENG SHAO, JIAN SHI, GUANGJI WANG, XINWEN WANG, BEI YAN, YING ZHANG, CHUNYAN ZHAO, TIAN ZHENG
Принадлежит:

The invention discloses a method for quantitatively evaluating medicament toxicity by using metabonomic technology, which is characterized by comprising the following steps: comprehensively and quantitatively measuring small molecule compounds in a biological sample by using the measuring technology based on mass spectrum, nuclear magnetic resonance and the like, then establishing a multi-dimensional spatial mathematical model by adopting a multi-variable data processing method, calculating a relative distance between an administration group and a control group and taking the relative distance as a quantitative index for evaluating the medicament toxicity so as to solve the difficult problem that the medicament toxicity evaluation lacks the quantitative evaluating index. Compared with the conventional toxicity evaluating method, the method has the advantages of wide application, sensitivity, simple and convenient sampling, no harm to the body, and capability of reflecting the toxicity function ...

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Номер записи: 9
16-07-2014 дата публикации

Application of demethyleneberberine in preparation of hypolipidemic drug

Номер: CN103919774A
Автор: A JIYE, WANG GUANGJI, SUN RUNBIN, MA TING, FEI FEI, XIAO WENJING, YU XIAOYI
Принадлежит:

The invention provides a hypolipidemic compound demethyleneberberine. The demethyleneberberine is derived from a main in-vivo metabolite of natural medicine berberine. The researches on model animals with hyperlipidemia find that the demethyleneberberine has good drug effects of reducing cholesterol, triglyceride, low density lipoprotein (LDL) and the like, and has no obvious side effects for 6 weeks of continuous medication. The discovery can lead to discovery of a new hypolipidemic drug, and provides another alternative medicine for clinic treatment of hyperlipidemia, lipid metabolism disorder and high fat and obese patients and related people wanting to lose weight.

Подробнее
Номер записи: 10