Apparatus for controlling underwater based equipment

The apparatus may include a space frame on which is mounted at least one hydrofoil for generating positive or negative lift. The frame is attachable to underwater equipment such as a turbine. The hydrofoils are adapted to produce negative lift when a flow of liquid passes over them and so in use cause the apparatus and attached equipment to sink to the seabed. The flow of water over the hydrofoils continue to produce negative life and so maintain the apparatus on the seabed. In certain embodiments, the hydrofoils can typically be set to a passive configuration in which they flip over when the current flow changes direction. Furthermore, the hydrofoils are selectively rotatable to provide an angle of attack such that they may be adapted to provide positive lift when it is necessary to remove the apparatus from the water.

A fire extinguisher

A fire extinguisher 100 comprises a housing 101 for containing a fire extinguishing substance (110, figure 2a). The housing comprises an opening 102 which is closed by a lid 103 to prevent the substance exiting the housing. The lid is configured to release from the housing to allow the substance to exit through the opening to extinguish a fire when heat is applied to the fire extinguisher. The fire extinguisher further comprises at least one arm 105, 106 which is located at least partly in a cavity of the housing which is for containing the fire extinguishing substance, and the at least one arm is configured to actuate to expel the fire extinguishing substance from the housing when the lid is released. A heat-sensitive wax seal 107 may be provided between the lid and the housing and may be configured to release the lid from the housing when heat is applied. In a preferred embodiment, the fire extinguisher may be installed inside of a household electrical appliance such a washing machine ...

A fire extinguisher

Apparatus for controlling underwater based equipment

The apparatus may include a space frame on which is mounted at least one hydrofoil for generating positive or negative lift. The frame is attachable to underwater equipment such as a turbine. The hydrofoils are adapted to produce negative lift when a flow of liquid passes over them and so in use cause the apparatus and attached equipment to sink to the seabed. The flow of water over the hydrofoils continue to produce negative life and so maintain the apparatus on the seabed. In certain embodiments, the hydrofoils can typically be set to a passive configuration in which they flip over when the current flow changes direction. Furthermore, the hydrofoils are selectively rotatable to provide an angle of attack such that they may be adapted to provide positive lift when it is necessary to remove the apparatus from the water.

Apparatus for controlling underwater based equipment

The apparatus may include a space frame on which is mounted at least one hydrofoil for generating positive or negative lift. The frame is attachable to underwater equipment such as a turbine. The hydrofoils are adapted to produce negative lift when a flow of liquid passes over them and so in use cause the apparatus and attached equipment to sink to the seabed. The flow of water over the hydrofoils continue to produce negative life and so maintain the apparatus on the seabed. In certain embodiments, the hydrofoils can typically be set to a passive configuration in which they flip over when the current flow changes direction. Furthermore, the hydrofoils are selectively rotatable to provide an angle of attack such that they may be adapted to provide positive lift when it is necessary to remove the apparatus from the water.

Apparatus for controlling underwater based equipment

The apparatus may include a space frame on which is mounted at least one hydrofoil for generating positive or negative lift. The frame is attachable to underwater equipment such as a turbine. The hydrofoils are adapted to produce negative lift when a flow of liquid passes over them and so in use cause the apparatus and attached equipment to sink to the seabed. The flow of water over the hydrofoils continue to produce negative life and so maintain the apparatus on the seabed. In certain embodiments, the hydrofoils can typically be set to a passive configuration in which they flip over when the current flow changes direction. Furthermore, the hydrofoils are selectively rotatable to provide an angle of attack such that they may be adapted to provide positive lift when it is necessary to remove the apparatus from the water.

WAGERING GAME, GAMING MACHINE, GAMING SYSTEM, AND METHOD WITH A PLAYER-DETERMINABLE FEATURE GAME ASPECT

A wagering game, gaming machine, networked gaming system, and associated methods are disclosed including a bank of gaming machines connected to an overhead display enabling players at the respective gaming machines to qualify to play a player-interactive community feature game displayed on the overhead display wherein each qualified player may sequentially launch one or more virtual objects or projectiles and accumulate awards as the objects traverse a virtual surface shown on the overhead display. A stand-alone wagering game with a player-interactive feature game is also disclosed. Additionally disclosed is a web-based community game system wherein players may login, accumulate points, and redeem awards either online or at networked casino site. 1. A method of providing a player-interactive feature game , the method including:receiving one or more primary game inputs through a gaming machine to initiate one or more plays of a primary game;after the one or more plays of the primary game, initiating a feature game in which a respective outcome is defined by a function of at least two independent variables and in which each respective outcome is associated with a respective probability of obtaining that outcome such that the feature game provides a spectrum of feature game outcome probabilities;setting a respective value for each of the at least two independent variables, wherein the value set for at least one of the at least two independent variables is dictated by a player selection received through the gaming machine, and wherein the value set for at least one of the at least two independent variables is determined randomly or pseudo-randomly; anddetermining the outcome of the feature game based on the values set for the at least two independent variables.2. The method of wherein the respective outcomes of the feature game are defined by a function of two independent variables.3. The method of wherein the respective outcomes of the feature game are defined by a ...

GAMING SYSTEM, METHOD, AND PROGRAM PRODUCT WITH PAYTABLE ENHANCEMENTS

A method includes displaying a number of enhancement symbols concurrently on a display device included at a gaming machine through which a wagering game may be played. The wagering game has a paytable providing at least one award level correlated to a payout value. Each of the displayed enhancement symbols is correlated to a payout modification. At least one of these enhancement symbols is selected and shown on the display device as being selected for a given play of the wagering game. The payout modification correlated to the selected enhancement symbol is used to identify a modified payout value for the outcome generated and displayed graphically for play of the game. This modified payout value is awarded for the given play of the game in lieu of or in addition to the payout value shown in the paytable for the outcome. 1. A method including:displaying a number of enhancement symbols concurrently on a display device included at a gaming machine, each enhancement symbol being correlated to a payout modification;receiving a wager at the gaming machine and initiating a play of a game available through the gaming machine, the game being associated with a paytable providing at least one award level which is correlated to a respective payout value;generating an outcome for the play of the game and displaying a graphical representation of the outcome;continuing to display the number of enhancement symbols between the time that the play of the game is initiated and the time that the graphical representation of the outcome is displayed;randomly selecting one of the enhancement symbols, and visually indicating at the gaming machine that the selected enhancement symbol has been selected;applying the payout modification correlated to the selected enhancement symbol to identify a modified payout value for the play of the game, the modified payout value being different from the payout value for the outcome that would be provided according to the paytable; andawarding the ...

CAPILLARY ELECTROPHORESIS-ELECTROSPRAY IONIZATION-MASS SPECTROMETRY SYSTEM

Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Some embodiments use a high voltage isolated CE power supply that is configured to float on the high voltage output of an ESI-MS power supply, with a protective resistance in the ESI-MS path, as well as DC/DC converter isolation and communication system isolation for the isolated CE power supply. Some embodiments additionally use a cartridge assembly integrating separation and conductive fluid capillaries with fluid cooling and protective retractable housings for the capillary end portions and for the ESI output. The protective housing may further be used with an adapter for interfacing with different MS systems. 1. An electrical circuit comprising:a first dc power supply having a first output and a first input;a first resistive electrical path connected to a ground that provides a first dc power supply return from the first output to the first input;a second dc power supply having a second output and a second input;a second resistive electrical path that provides a second dc power supply return from the second output to the second input, wherein the second resistive electrical path is isolated from the ground, and wherein the first output is electrically coupled with the second input;an isolated control circuit that is electrically coupled with the second dc power supply and is isolated from the ground, wherein the isolated control circuit is communicatively coupled with an interface board via a communication link, and wherein the communication link maintains isolation from the ground; anda DC/DC converter that provides isolated input power to the second dc power supply and the isolated control circuit.2. The electrical circuit of wherein the second resistive electrical path is electrically coupled to an electro-spray (ES) ...

THERMALLY SENSITIVE CONTROLS

A thermally sensitive control for controlling a power supply circuit to a heater in a liquid heating appliance is provided. The control includes a cordless connector part arranged to mate with a base connector part, first and second moveable electrical contacts mounted on first and second moveable members, and first and second thermally sensitive actuators. The control further includes a latch arm extending across the control between the moveable members, the latch arm including a first latch for the first moveable member and a second latch for the second moveable member, and a release member including a release part and a plunger, wherein the release member is resiliently biased to bring the release part into contact with the latch arm but the resilient bias is overcome when the plunger bears against a surface of the base connector part. 1. A thermally sensitive control for controlling an electrical power supply circuit to a heater in a liquid heating appliance , the control comprising:a cordless electrical connector part arranged to mate with a corresponding base electrical connector part;first and second moveable electrical contacts mounted on first and second moveable members, each mating with a corresponding fixed electrical contact in the electrical power supply circuit when the first and second moveable members are respectively in a closed position;first and second thermally sensitive actuators, each independently operable at an overheat temperature to move a respective one of the first and second moveable members from the closed position to an open position wherein the first and second moveable electrical contacts are separated from the fixed electrical contacts to interrupt the electrical power supply circuit;a pivotally mounted latch arm extending laterally across the control between the first and second moveable members, the latch arm comprising a first latch for the first moveable member and a second latch for the second moveable member; anda release ...

FLOW HEATERS

A flow heater is provided including a heating element, a channel heated by said heating element for heating liquid flowing therethrough, and temperature sensing means in thermal communication with both the heating element and the channel so as to be sensitive to the temperature of the liquid in the channel and the temperature of the heating element. 1. A flow heater comprising a heating element , a channel heated by said heating element for heating liquid flowing therethrough , and a temperature sensor in thermal communication with both the heating element and the channel so as to be sensitive to the temperature of the liquid in the channel and the temperature of the heating element.2. The flow heater as claimed in claim 1 , wherein the temperature sensor is arranged to remove or reduce power to the heating element when the temperature sensor detects a predetermined temperature condition.3. The flow heater as claimed in claim 1 , wherein the temperature sensor is arranged outside of the channel and the heating element.4. The flow heater as claimed in claim 1 , wherein the heating element and the channel comprise a contact area bridging the heating element and the channel claim 1 , and with which the temperature sensor is in thermal communication.5. The flow heater as claimed in claim 1 , wherein the temperature sensor comprises a bimetallic actuator.6. The flow heater as claimed in claim 1 , wherein the heating element is mounted to or in contact with a wall of the channel.7. The flow heater as claimed in claim 6 , wherein the wall is an outer wall of the channel.8. The flow heater as claimed in claim 1 , wherein the heating element comprises a sheathed resistance heating element.9. The flow heater as claimed in claim 1 , wherein the heating element has a power greater than 1 kW.10. The flow heater as claimed in claim 1 , wherein the channel comprises a first portion in fluid communication with a second portion claim 1 , said first and second portions each being ...

WEBFORM MONITORING

A system for monitoring the performance of the webform comprising: a detection module an archive module a database an analysis module and intervention module one or more help modules and a reporting module The detection module is operable to detect user interaction with the webform. The archive module is operable to store details of the detected user interactions in the database The analysis module is operable to compare detected user interactions with one or more of the templates stored in the database Based on this comparison, the analysis module may determine a performance indication for the detected interactions. The intervention module is operable in response to a negative performance indication to categorise the performance indication by identifying one or more negative ratings values and to activate one or more help modules which can activate additional functionality on the webform and/or provide a connection to additional data or devices. The reporting module generates reports based upon the data stored in the database

IMPROVED CAPILLARY ELECTROPHORESIS-ELECTROSPRAY IONIZATION-MASS SPECTROMETRY SYSTEM

Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Some embodiments use a high voltage isolated CE power supply that is configured to float on the high voltage output of an ESI-MS power supply, with a protective resistance in the ESI-MS path, as well as DC/DC converter isolation and communication system isolation for the isolated CE power supply. Some embodiments additionally use a cartridge assembly integrating separation and conductive fluid capillaries with fluid cooling and protective retractable housings for the capillary end portions and for the ESI output. The protective housing may further be used with an adapter for interfacing with different MS systems. 2. (canceled)4. (canceled)6. (canceled)7. (canceled)9. (canceled)10. The electrical circuit of wherein the interface board is part of an CE analysis system;wherein the communications link is an optical communications link;wherein the interface board receives an analog control signal, converts the analog control signal to a digital logic pulse stream which is routed to the isolated control circuit; andwherein the isolated control circuit converts the digital logic pulse stream back into the analog control signal and controls the second DC power supply using the analog control signal.11. The electrical circuit of further comprising a voltage limit resistor coupled directly with the first dc power supply claim 1 , wherein said voltage limit resistor is in the first resistive electrical path and is not in the second resistive electrical path and optionally wherein the communication link and the DC/DC converter each is able to withstand a voltage greater than or equal to a maximum output voltage of the first dc power supply claim 1 , a maximum output voltage of the second dc power supply claim 1 , or a voltage that is a sum of ...

ALIGNMENT BELT AND METHOD OF USING

An alignment belt has a main strap and a removable handle for positioning the strap about a person's pelvic region to more readily stretch specific areas of the body to remove stress from muscle, ligaments, tendons and connective tissue. In addition, methods of using and manufacturing the alignment belt are also disclosed. 1. A belt for assisting a practitioner in stretching and aligning a patient's body , the belt comprising:a main strap positionable and tightenable about a patient's body; anda removable handle with a handle grip, the removable handle engageable with the main strap.2. The belt according to claim 1 , wherein the main strap includes a buckle for securing the main strap about the patient's body.3. The belt according to claim 1 , wherein the main strap comprises an inside surface of a slip-resistant material selected from the group consisting of amorphous atactic olefin polymers claim 1 , copolymers of propylene and a terminally unsaturated olefin claim 1 , and combinations thereof.4. The belt according to claim 1 , the main strap comprising a first end having a securing portion attachable to and removable from an outside surface of the main strap.5. The belt according to claim 4 , wherein the securing portion releasably engages the outside surface of the main strap using a hook-and-loop type fastener.6. The belt according to claim 1 , the removable handle having a handle attachment tab with strips attached thereto claim 1 , the handle grip having slotted orifices for receiving the strips claim 1 , the handle grip thereby slidably connected to the strips and stopped by knots on terminal ends of the strips.7. The belt according to claim 6 , further comprising hollow shells fitted over each knot.8. The belt according to claim 7 , wherein the slotted orifices in the handle grip are sized to be stopped by the hollow shells. This application claims priority to U.S. Provisional Application No. 62/490,129 filed Apr. 26, 2017, the content of which is hereby ...

Sulfonamide derivatives

Sulfonamide derivatives of formula (1) are described wherein X is an O or S atom; Y is an 0 or S atom; A is a group -S02NR1R2; m is zero or the integer 1; n is zero or the integer 1; provided that at least one but not both of m and n are the integer 1; R3 is a hydrogen atom or an alkyl or cycloalkyl group; and the salts, solvates, hydrates, tautomers, isomers, N-oxides thereof. The compounds are potent inhibitors of IMPDH and are of use as immunosuppressants, anti-cancer agents, anti-inflammatory agents, antipsoriatic and anti-viral agents.

Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity

Microprocessor controlled electronic stimulating device having biphasic pulse output

An electronic stimulating device is disclosed, with the stimulating device particularly illustrated being a transcutaneous nerve stimulating (TENS) device for effecting suppression of pain by nerve fiber stimulation. Biphasic constant current output pulses are applied to a user through electrode pairs noninvasively positioned at the skin of the user. Microprocessor generated control pulses control generation of the biphasic output pulses at a biphasic output stage associated with each electrode pair, and the generated biphasic output pulses are capacitively coupled from each output stage which also includes a bleeder network for effecting capacitor discharge. Stimulation may be continuously applied at a level selected by the user or may be applied in timed varying intensities the maximum level of which is selectable, and displays of intensity and sensed faults, including low battery voltage, are also provided.

Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity

4-(4-(4-Chlorophenyl)piperazin-1-yl)sulfonylmethyl)-tetrahydorpyran-4- carboxylic acid and the corresponding N-hydroxy amide, and derivatives thereof, are useful as therapeutic agents.

Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.

5,6,7,8-Tetrahydroquinoxaline, process for their preparation and their use

Biphasic pulse output stage for electronic stimulating device

A biphasic pulse output stage is disclosed for an electronic stimulating device, such as a transcutaneous nerve stimulating device capable of effecting suppression of pain by nerve fiber stimulation. Biphasic constant current output pulses are applied to a user through an electrode pair noninvasively positioned at the skin of the user. Microprocessor generated control pulses control generation of the biphasic output pulses at one or more biphasic output stages each of which is associated with an electrode pair, and the generated biphasic output pulses are capacitively coupled from each output stage which also includes a bleeder network for effecting capacitor discharge.

Hydroxamic and carboxylic acid derivatives with MMP and TNF inhibitory activity

FERMENTATION PROCESS FOR THE PRODUCTION OF MICROORGANISMS

Peptidyl compounds and their therapeutic use

N-hydroxyformamide derivatives

Spinning cell

Output pulse compensation for therapeutic-type electronic devices

OUTPUT PULSE COMPENSATION FOR THERAPEUTIC-TYPE ELECTRONIC DEVICES Abstract of the Disclosure Pulse compensation is disclosed for electronic devices capable of producing a pulse output signal suitable for therapeutic purposes with pulse compensation being automatically provided upon sensing of a change in the conditions being monitored. The electronic device, which preferably includes a micro-computer, has externally accessible pulse width and intensity controls for determining the width and amplitude of pulses then being delivered. Upon each sensing of a change in a monitored condition capable of causing user discomfort or possible injury, the intensity of the pulses then being delivered is quickly reduced and then gradually increased toward the full intensity requested by the intensity control. Pulse compensation is also provided when the pulse width is varied by the pulse width control to thereby automatically cause a corresponding change in the range of intensities of the pulses then delivered, based upon a nerve fiber strength-duration curve of the pulses, to thereby maintain the stimulation capability of the pulses substantially constant at a percentage of intensity as determined by the intensity control.

Hydroxamate sulfonamides as cd23 shedding inhibitors

A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

Peptidyl compounds having mmp and tnf- liberation inhibitory activity

Compounds of general formula (I) having MMP and TNF inhibitory activity.

Spinning cell

A method of producing lyocell fibres (125) by spinning a solution of cellulose in an organic solvent through an air gap and into a spin bath (115) in which there is provided means (121, 122) to generate a cross-draught of air in the air gap.

Hydroxamate sulfonamides as cd23 shedding inhibitors

A class of piperazine and related heterocyclic derivatives, substituted at the 4-position by a substituted aryl or heteroaryl moiety, and at the 1-position by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

Systems within a communication device for evaluating movement of a body and methods of operating the same

The present invention introduces systems, as well as methods of operating such systems, within a communication device for evaluating movement of a body relative to an environment. According to an exemplary embodiment, the system comprises a sensor and a processor. The sensor, which is associable with the body, is operable to repeatedly sense accelerative phenomena of the body. The processor, which is associated with the sensor, is operable to process the sensed accelerative phenomena as a function of at least one accelerative event characteristic. The system, and, more particularly, the processor generates state indicia relative the environment, and determines whether the evaluated body movement is within environmental tolerance. In a preferred embodiment, the processor communicates various state indicia to a monitoring controller, preferably using at least one of a wired network and a wireless network. The monitoring controller cooperates with the processor to remotely monitor the body.

Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity

Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity

Systems within a position locator device for evaluating movement of a body

The present invention introduces systems, as well as methods of operating su ch systems, within a position locator device (103) for evaluating movement of a body relative to an environment. According to an exemplary embodiment, the system (11) comprises a sensor (25) and a processor (47). The sensor (25), which is associable with the body, is operable to repeatedly sense accelerative phenomena of the body. The processor (47), which is associated with the sensor (25), is operable to process the sensed accelerative phenome na as a function of at least one accelerative event characteristic. The system (11), and, more particularly, the processor (47) generates state indicia relative the environment, and determines whether the evaluated body movement is within environmental tolerance. In a preferred embodiment, the processor (47) communicates various state indicia to a monitoring controller (805), preferably using at least one of a wired network (800) and a wireless networ k (810). The monitoring controller (805) cooperates with the processor (47) to remotely monitor the body.

Hydroxamic and carboxylic acid derivatives

Hydroxamic acid derivatives as matrix metalloproteinase (mmp) inhibitors

Power services coupling

A coupling for an operator to connect power/service supply lines from a driver's cab (not shown) to outlets 2a,2b,2c comprises an outlet plate 2, moved by an operating handle H, with the outlets 2a,2b,2c on a slide arm 3 with a stop plate 4 to a coupling connection position lying laterally beyond the width of the trailer, from a first, operating position within the width of the trailer. The slide arm 3 is supported in between vertically spaced guide pins 5, 6 mounted on a plate 7 fixed to a slideway 8 having parallel upper and lower slide rails 9, 10 fixed to the front wall of a trailer. The coupling plate 2 and outlets 2a, 2b, 2c are at a first height relative to the slideway and trailer (and ground level), in the use position, and at a second, lower height level in the coupling connection position.

FLAVORING PROCEDURES AND MEANS

2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions

The present invention concerns novel 2 amino pyrimidine derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as harmaceuticals.

Peptidyl compounds and their therapeutic use as metalloprotease inhibitors

Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity

Compounds of formula (I) are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.

Peptidye-type compounds and their therapeutic application as inhibitors of metalloproteinases

1 Z w ia z k i m erkaptoalkilopeptydylow e o w z o rz e (I) w którym R 1 o znacza g rupe C 2-6-alkilow a albo C 1 -6-alkilo-O H , R2 oznacza atom w odoru albo grupe C 1 -6-alkilow a, R4 oznacza atom w odoru albo grupe C 1 -6-alkilow a; R5 oznacza atom w odoru albo grupe C 1 -6-alkilow a, R6 oznacza grupe C1-6 -alkilowa, benzylowa albo 3-indolilome- tylowa, A lk ozn acza grupe C 1-6-a lk ilo w a alb o C 2-6-alken ylow a, n ozn acza 0 alb o 1, R 7 oznacza atom w odoru albo grupe R 1 0 C O , w której R 10 o zna- cza grupe C 1 -4-alkilow a; R 8 oznacza atom w odoru, grupe C 1 -4 -alkilow a albo grupe ( C 1 -4-alkilo)arylow a. 4 Srodek farm aceutyczny zaw ierajacy fizjologicznie dopusz- czalny rozcienczalnik lub nosnik i substancje czynna, z n am ien n y ty m , ze substancje czynna stanow i zw iazek m erkaptoalkilopepty- dy lo w y o w zorze ( I), w którym . R oznacza grupe C 2-6-alkilow a albo C 1 -6-alkilo-O H , R 2 oznacza atom w odoru albo grupe C 1 -6-alkilow a, R4 oznacza atom w odoru albo grupe C 1 -6-alkilow a, R 5 oznacza atom w odoru albo grupe C 1 -6-alkilow a, R6 o znacza grupe C 1 -6-alkilow a, benzylow a albo 3 -indolilom e- tylow a, A lk oznacza grupe C 1 -6-alkilow a albo C 2-6-alkenylow a, n oznacza 0 albo 1, R 7 oznacza atom w odoru albo grupe R 1 0 C O , w której R 1 0 o zna- cza grupe C 1 -4-alkilow a, R8 oznacza atom w odoru, grupe C 1-4-alkilowa albo grupe (C 1-4-alkilo)arylow a. PL PL PL PL PL PL PL PL PL

Peptide compounds which inhibit metalloproteinase and TNF liberation, and their therapeutic use

Process for preparing natural benzaldehyde and acetaldehyde, natural benzaldehyde and acetaldehyde compositions, products produced thereby and organoleptic utilities therefor

Described is a process for preparing natural benzaldehyde and acetaldehyde and compositions of matter containing natural benzaldehyde and acetaldehyde as well as products produced thereby and organoleptic utilities therefor, which process comprises the step of contacting with base naturally occurring cinnamaldehyde or a natural product rich in cinnamaldehyde such as Ceylon oil of cinnamon, Ceylon cinnamon bark, Saigon cinnamon bark, cassia oil, Ceylon cinnamon quills, cinnamon leaf oil, oil of cinnamon Madagascar or the like according to the reaction: the reaction taking place in the absence of any other reagents except inert solvent. Described and claimed is an apparatus for carrying out said process.

Novel process for altering the organoleptic properties of tobacco using one or more alpha-pyrones and process

Described is a process comprising adding to tobacco an amount sufficient to alter the flavor or aroma of the tobacco, one or more alpha-pyrone compounds having the generic structure: WHEREIN R1 is methyl or hydrogen, and R2 is C3-C5 alkyl; processes for producing such tobacco products; and flavor formulations for use in conjunction with tobacco products containing one or more of such alpha-pyrones.

Heterocyclic compounds having mmp and tnf inhibitory activity

Compounds of formula (I) are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.

Process for producing lyocellulose fibers

A method of producing lyocell fibres (125) by spinning a solution of cellulose in an organic solvent through an air gap and into a spin bath (115) in which there is provided means (121, 122) to generate a cross-draught of air in the air gap.

Novel heterocyclic flavoring compositions and processes

5-methyl-α - [(methylthio) methyl] -2-furanacrolein, process for its preparation and use as a seasoning or as an additive to seasoning mixtures for foods

Flavoring methods and compositions

Peptidyl compounds having MMP and TNF inhibitory activity.

Derivatives of hydroxamic and carboxylic acid and their use

The invention concerns hydroxamic acid and carboxylic acid derivatives of formulae (I): B-X-(CH2)n-CHR<1>-(CH2)m-CONHOH and (Ia): B-S(O)1-2-(CH2)n-CHR<1>-(CH2)m-COOR<2>, in which X is O, NR3 or S(O)0-2, and the other variables have the definitions given in the claims, having MMP and TNF inhibitory activity.

Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases

Compounds of general formula (I) have utility as inhibitors of matrix metalloproteinases and TNF.

STORAGE ARRANGEMENT, MADE WITH AMORPHOUS SILICON.

PCT No. PCT/GB90/00692 Sec. 371 Date Sep. 25, 1991 Sec. 102(e) Date Sep. 25, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13921 PCT Pub. Date Nov. 15, 1990.An analogue memory device comprises a layer of doped amorphous silicon located between a first conducting layer metal contact layer of V, Co, Ni, Pd, Fe or Mn. It has been found that the selection of one of these metals as the contact exerts a significant effect on the properties of the device, e.g. the selection of Al, Au or Cu gives no switching whereas Cr, W, Ag give digital instead of analogue switching.

SUBSTITUTED THIAZOLES

Peptidyl compounds and their therapeutic use

Dipeptidyl derivatives having a SH of acylS group and which are amides, thioamides or S(O) 0-2 -amides, have therapeutic utility via MMP or TNF inhibition.

Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases

System and method for analyzing activity of a body

The present invention comprises a system and method of operation for evaluating body activity relative to an environment. According to an exemplary embodiment, the system comprises a processor that is associable with a sensor for sensing dynamic and static accelerative phenomena of the body. The processor is operable to process the sensed dynamic and static accelerative phenomena as a function of at least one accelerative event characteristic and an environmental representation to thereby determine whether the evaluated body activity is within environmental tolerance. The processor operates to monitor both activity and inactivity relative to the environmental representation.

Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation.

Los compuestos de la formula (I), los péptidos son inhibidores de metaloproteínas (de matriz) así como de colagenasa y estromelisina. Adicionalmente, inhiben la liberacion de factor de necrosis tumoral alfa (TNFalfa).

Output pulse compensation for therapeutic-type electronic devices

Pulse compensation is disclosed for electronic devices capable of producing a pulse output signal suitable for therapeutic purposes with pulse compensation being automatically provided upon sensing of a change in she conditions being monitored. The electronic device, which preferably includes a microcomputer, has externally accessible pulse width and intensity controls for determining the width and amplitude of pulses then being delivered. Upon each sensing of a change in a monitored condition capable of causing user discomfort or possible injury, the intensity of the pulses then being delivered is quickly reduced and then gradually increased toward the full intensity requested by the intensity control. Pulse compensation is also provided when the pulse width is varied by the pulse width control to thereby automatically cause a corresponding change in the range of intensities of the pulses then delivered, based upon a nerve fiber strength-duration curve or the pulses, to thereby maintain the stimulation capability of the pulses substantially constant at a percentage of intensity as determined by the intensity control.

Peptidyl compounds and their therapeutic use as metaloproteinase inhibitors

Compounds of general formula (I) have utility as inhibitors of matrix metalloproteinases and TNF.

DEVICE FOR SETTING A UNDERWATER DEVICE TO A MARINE MILK.

Dispositivo de ubicación subacuática (1) para fijar un dispositivo subacuático mientras funciona en un lecho marino o lecho de río, comprendiendo el dispositivo de ubicación subacuática: unos medios de fijación (10) para fijar un dispositivo subacuático al dispositivo de ubicación subacuática; y por lo menos un elemento (12) para generar una elevación negativa de manera que, durante su uso, la corriente de fluidos que pasa por el por lo menos un elemento proporcione una fuerza descendente para empujar el dispositivo de ubicación subacuática hacia el lecho marino o el lecho del río para de esa manera mantener el dispositivo de ubicación subacuática en su sitio en el lecho marino o en el lecho del río. Underwater location device (1) for fixing an underwater device while operating on a seabed or river bed, the underwater location device comprising: fixing means (10) for fixing an underwater device to the underwater location device; and at least one element (12) for generating a negative elevation so that, during use, the flow of fluids passing through the at least one element provides a downward force to push the underwater location device towards the seabed or the riverbed to thereby keep the underwater location device in place on the seabed or on the riverbed.

Derivatives of hydroxamic and carboxylic acids

For the treatment of cancer, inflammation and other conditions associated with matrix metalloproteinases or that are mediated by TNF alpha or enzymes involved in the shedding of L-selectin, CD23, the TNF receptors, IL-1 receptors or IL-6 receptors, compounds are of general formula (I) B-X-(CH2)m-(CR<1>R<2>)n-W-COY.

Peptide compounds which inhibit metalloproteinase and tnf liberation, and their therapeutic use

Peptidyl compounds have therapeutic utility via MMP/TNF inhibition.

Photo-conductive cell

Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity

Compounds of formula (I) are useful as therapeutic agents, by virtue of having MMP and TNF inhibitory activity.

Substituted thiazole flavoring agents

Peptidyl compounds and their therapeutic use

Peptidyl derivatives having an SH or acylo groups and which are amides, primary amides or thioamides, have therapeutic utility via MMP or TNF inhibition.

Device for securing an underwater device on a seabed

5-Methyl-alpha[(methylthio)methyl]-2-furan acrolein

Processes and compositions are described for use in foodstuff flavors and as foodstuff article aroma and taste augmenting and enhancing materials of at least one alpha-substituted alkylidene methionals having the structure: ##STR1## wherein R 1 or R 2 is one of the moieties: ##STR2## AND THE OTHER IS HYDROGEN OR METHYL. Addition of one or more alpha-substituted alkylidene methionals to foodstuff flavorings or to foostuffs is indicated to produce the following aroma and flavor characteristics, in the alternative taken together: Aroma Potato; Methional-like; Green; Hydrolyzed vegetable protein-like; Chicken-like; Cabbage; Green potato; Green weedy; Broccoli-like; and Green bean-like. Flavor Potato; Metallic; Sulfury-green; Cabbage-like; Chicken; Mushroom-like; Green-weedy; Broccoli-like; and Green bean-like. The compounds of our invention are useful in augmenting or enhancing the flavor and aroma nuances of vegetable (including potato and cabbage) and chicken flavors.

Spinning cell

Hydroxamate sulfonamides as cd23 shedding inhibitors

A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

Semiconductor device

An analogue memory device comprises a layer of doped amorphous silicon located between a first conducting layer and metal contact layer of V, Co, Ni, Pd, Fe or Mn. It has been found that the selection of one of these metals as the contact layer exerts a significant effect on the properties of the device, e.g. the selection of Al, Au or Cu gives no switching whereas Cr, W and Ag give digital instead of analogue switching.

Apparatus and method for reducing power consumption in physiological condition monitors

Semiconductor device

SUBSTITUTE REMPLACEMENT SECTION is not Present Cette Section est Absente

PEPTIDE COMPOUNDS WITH MMP AND TNF INHIBITING EFFECT

System within a communication device for evaluating movement of a body and methods of operating the same

The present invention introduces systems, as well as methods of operating such systems, within a communication device for evaluating movement of a body relative to an environment. According to an exemplary embodiment, the system comprises a sensor and a processor. The sensor, which is associable with the body, is operable to repeatedly sense accelerative phenomena of the body. The processor, which is associated with the sensor, is operable to process the sensed accelerative phenomena as a function of at least one accelerative event characteristic. The system, and, more particularly, the processor generates state indicia relative the environment, and determines whether the evaluated body movement is within environmental tolerance. In a preferred embodiment, the processor communicates various state indicia to a monitoring controller, preferably using at least one of a wired network and a wireless network. The monitoring controller cooperates with the processor to remotely monitor the body.

HYDROXAMIC ACID AND CARBONIC ACID DERIVATIVES WITH MMP AND TNF INHIBITING EFFECT

Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity

A pharmacologically active compound of formula (I) wherein having MMP and TNF inhibitory activity for use in the treatment of cancer, inflammation, or an autoimmune, infections or ocular disease.

Resistive memory element

The resistance of a resistive memory element, e.g. a synaptic element is programmed, e.g. adjusted to a target value, by pulses of a constant height and variable width. One polarity gives an increase in resistance; the other polarity gives a decrease. A short pulse applied after a longer pulse appears to have no effect. After each polarity change short pulses can again be used to make small adjustments. In a preferred embodiment longer and longer pulses are used until the resistance overshoots the target value. After overshooting the polarity is reversed and a second series of pulses is used to obtain a closer approach to the target. The resistive element comprises a resistive layer located between two electrodes, e.g. a matrix of amorphous silicon doped with boron containing V. One electrode is Cr and the other is V.

Method, system, and program product for providing predetermined-prize bonus round play in a game

In a method, apparatus and program product for adding a "predetermined-prize bonus" round to a game, such a bonus round includes activity that leads to the revealing of a hidden result (508) for the game. Where the underlying game comprises a bingo game, the game play result (502) includes a bingo card pattern and payout amount for an otherwise ordinary result of the game. A player makes a selection (507) in the predetermined-prize bonus round, but the selection has no affect on the amount awarded for the game, since the amount is determined prior to the player's selection (507).

SULFUR-SUBSTITUTED PEPTIDES AS INHIBITORS FOR METALLOPROTEINASES AND TNF RELEASE

Dipeptide compounds have therapeutic utility, inter alia, as metalloproteinase and TNF inhibitors.

Flow heaters

A flow heater (1) comprising a heating element (2), a channel (4,5) heated by said heating element (2) for heating liquid flowing therethrough, and temperature sensing means (38) in thermal communication with both the heating element (2) and the channel (4,5) so as to be sensitive to the temperature of the liquid in the channel (4,5) and the temperature of the heating element (2).

Peptidyl compounds and their therapeutic use

Peptidyl compounds and their therapeutic use as inhibitors of metalloproteases

Novel fragrance compositions and perfumed articles containing alpha-substituted acetaldehyde

Processes and compositions are described for the use in perfume aroma imparting, augmenting, modifying, altering or enhancing compositions and as perfume and perfumed article aroma imparting, modifying, altering and enhancing materials of 2,2,6-trimethyl-1-cyclohexene-1-ylacetaldehyde (hereinafter referred to as "beta-cyclohomocitral") produced by a process which either (A) comprises the steps of: I. Oxidizing beta-ionone having the formula: ##STR1## with a peralkanoic acid having the formula: ##STR2## (wherein R is H, methyl or ethyl) in the presence of buffer and in the absence of dimethyl formamide, to form 2,2,6-trimethyl-1-cyclohexene-1-ylvinylacetate (hereinafter referred to as "beta-ionone enol ester") having the formula: ##STR3## and II. Hydrolyzing said beta-ionone enol ester using a basic hydrolysis agent to form beta-cyclo-homocitral having the structure: ##STR4## or (B) oxidizing beta-ionone with hydrogen peroxide in the presence of inorganic base to form beta-cyclohomocitral, directly. Addition of beta-cyclohomocitral is indicated to produce in perfumes, woody, camphoraceous, green, earthy and rosey notes, or enhance in perfume compositions and perfumed articles, floral (especially rosey) notes.

Video poker system and method with bet allocation

A method includes displaying a first set of card representations at a display device of a player station. This first set of card representations is divided into a number of card representation subsets. The method also includes receiving a subset selection input and a wager allocation input at the player station. The subset selection input selects a first and second subset of card representations from the various subsets that have been displayed. Each of these different subsets will be used together with a second, “community” set of card representations displayed at the player station to produce a respective final hand for the player. The wager allocation input allocates a wager amount between the first and second subsets of card representations. First and second prize values are awarded for hands produced from the selected subsets combined with the community card set and considering the wager allocations.

Hydroxamic and carboxylic acid derivatives

Compounds (many of which are new) that have utility in the treatment of a condition associated with matrix metalloproteinase, ADAM or ADAM-TS enzymes, a condition that is mediated by TNF .alpha. or a condition involving a membran e- shedding event that is mediated by a metalloproteinase, are of formula (I): (B)2N-X-(CH2)m-W-(CR1R2)n-COY, wherein n= 0 or 1; m =0 or 1; X is S(O)1-2; Y is OH or NHOH; W is aryl or heteroaryl; and the other groups are as defined herein.

Flow heaters

A flow heater (1) comprising a heating element (2), a channel (4,5) heated by said heating element (2) for heating liquid flowing therethrough, and temperature sensing means (38) in thermal communication with both the heating element (2) and the channel (4,5) so as to be sensitive to the temperature of the liquid in the channel (4,5) and the temperature of the heating element (2).

FLAVORING AGENTS

PROCESS FOR THE CHARACTER OF SOLVENT CELLULOSE FILAMENTS

Selektive mmp inhibitoren mit verringerten nebenwirkungen

Cross-linking and dyeing cellulose fibres

A process for producing an evenly-dyed fabric comprising both cotton fibres and man-made cellulose fibres, in which a fabric is manufactured from both said fibres and is dyed, is characterised by impregnating the man-made cellulose fibres, prior to manufacture of the fabric, with a water-soluble, flexible linear polymer and a cross-linking agent reactive with cellulose, and, at a stage of the process prior to dyeing of the fabric, effecting a cross-linking reaction between the man-made cellulose fibres and the cross-linking agent, thereby producing a reduction in the dye affinity of the man-made cellulose fibres to a level more proximate to the dye affinity of the cotton fibres.

Cross-linking and dyeing cellulose fibres

A process for producing an evenly-dyed fabric comprising both cotton fibres and man-made cellulose fibres, in which a fabric is manufactured from both said fibres and is dyed, is characterised by impregnating the man-made cellulose fibres, prior to manufacture of the fabric, with a water-soluble, flexible linear polymer and a cross-linking agent reactive with cellulose, and, at a stage of the process prior to dyeing of the fabric, effecting a cross-linking reaction between the man-made cellulose fibres and the cross-linking agent, thereby producing a reduction in the dye affinity of the man-made cellulose fibres to a level more proximate to the dye affinity of the cotton fibres.

Hydroxamatsulfonamide als inhibitoren von cd23- shedding

Process for producing tastands including food, chewing gum, beverage, oral care composition and tobacco additives from saccharum officinarum leaves, products produced thereby and uses thereof in imparting, augmenting and/or enhancing the aroma and taste of foodstuffs, chewing gums, oral care compositions, beverages and tobacco and diminishing bitter or metallic tastes of eatables

Keto-ester composition

A process is described for the preparation of 6-alkyl-alpha-pyrones which comprises the steps of:

Hydroxamsäure- und carbonsäurederivate mit mmp und tnf hemmender wirkung

Selektive mmp inhibitoren mit verringerten nebenwirkungen

Hydroxam- und carbonsäurederivate mit mmp- und tnf-hemmender aktivität

Peptidartige stoffe, die metalloproteinasen und die tnf-freisetzung hemmen, und ihre therapeutische verwendung

N-hydroxyformamid-derivate

Heterozyklische verbidungen mit mmp und tnf inhibitorisher wirkung

Verfahren für das verspinnen von cellulosefasern aus der lösung