THERAPY WITH CLOSTRIDIUM PERFRINGENS ENTEROTOXIN TO TREAT OVARIAN AND UTERINE CANCER

The invention discloses high levels of receptors for enterotoxin (CPE) have been found in ovarian cancer and uterine cancer tissue samples. In addition, successful in vivo treatment of a mouse model of ovarian cancer with intraperitoneal injection of CPE is disclosed. High levels of Ep-CAM protein is also disclosed in ovarian cancer tissue samples. Thus, the invention provides a method of treating ovarian cancer and uterine cancer by administering CPE. The invention also provides a method of treating cancer in a mammal involving intraperitoneal administration of CPE, where at least some cancerous cells are located in or adjacent to the peritoneal cavity of the mammal. The invention also provides a method of treating ovarian cancer involving administering an anti-Ep-CAM antibody. The invention also provides a method of treating cancers expressing claudin-3 or claudin-4 by administering an antibody against claudin-3 and/or an antibody against claudin-4. The invention also provides a method of protecting a mammal from CPE toxicity involving administering a protective agent that binds to claudin-3 and/or claudin-4 and inhibits CPE binding to claudin-3 and/or claudin-4. 1. A method of treating cancer in a human comprising:{'i': 'Clostridium perfringens', 'administering to the human a therapeutically effective amount of enterotoxin (CPE) or a pharmaceutically effective salt thereof;'}wherein the cancer is ovarian serous papillary carcinoma, ovarian clear cell carcinoma, or uterine serous papillary carcinoma;wherein the CPE is native CPE (SEQ ID NO:1) or a variant thereof comprising a sequence at least 90% identical to residues 45-319 of SEQ ID NO:1;wherein the CPE or pharmaceutically acceptable salt thereof is administered intravenously or intraperitoneally.2. The method of wherein the cancer includes chemotherapy-resistant malignant cells and chemotherapy-sensitive malignant cells claim 1 , and the CPE preferentially binds to chemotherapy-resistant malignant cells over ...

Gene Expression Profiling in Primary Ovarian Serous Papiliary Tumors and Normal Ovarian Epithelum

Provided herein are methods for detecting ovarian serous papillary carcinoma in an individual. A tumor sample from the individual is examined for gene product expression levels of a group of genes consisting of transforming growth factor beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family member I (ARHI), thrombospondin 2, and disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2) Gene products which are down-regulated compared to those in a control individual indicate the presence of ovarian serous papillary carcinoma 1. A method of detecting ovarian serous papillary carcinoma in an individual , comprising the steps of:examining a tumor sample from said individual by the expression levels of gene products of a group of genes consisting of transforming growth factor beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family member I (ARHI), thrombospondin 2, and disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2) gene; wherein downregulation of the gene products of said group of genes compared to a control individual indicates that the tumor sample is an ovarian serous papillary carcinoma.2. The method of claim 1 , wherein the gene product expression is examined by flow cytometry or immunohistochemical staining. This application is a divisional under 35 U.S.C. §120 of pending application U.S. Ser. No. 13/066,004, filed Apr. 4, 2011, which is a divisional under 35 U.S.C. §120 of application U.S. Ser. No. 10/862,517, filed Jun. 7, 2004, now U.S. Pat. No. 7,927,795, which is a nonprovisional under 35 U.S.C. §119(e) of provisional patent application U.S. Ser. No. 60/476,934, filed Jun. 9, 2003, now abandoned, the entirety of all of which are hereby incorporated by reference.1. Field of the InventionThe present invention relates generally to the field of cancer research. More specifically, the present invention relates to gene expression profiling ...

IN-SYSTEM PROM EMULATOR BOARD

Apparatus for in-system emulation of a target non-volatile memory device, such as a target PROM that stores FPGA configuration files and general data. The in-system emulation apparatus serves as stand-in hardware for the target PROM within the target system, mounted within a surface mount footprint and within volume constraints of the target PROM in the target system. The apparatus for in-system PROM emulation includes a device converter, and a surface mount emulator foot. The device converter includes at least one reprogrammable memory device, which stores developmental data that emulates data stored by the target PROM. The device converter includes a device converter circuit board, secured to the surface mount emulator foot. The device converter may include four Flash PROM reprogrammable devices, mounted above and below the device converter circuit board. The surface mount emulator foot includes an emulator foot circuit board, and a surface mount package emulation adapter. 1. An apparatus for in-system emulation of a target non-volatile memory (target NVM) in a target system , the target NVM being a non-volatile memory device that stores data , and the target NVM being mounted to a surface mount footprint within a volume of the target NVM in the target system , the apparatus comprising:a device converter including a device converter circuit board and at least one reprogrammable memory device electrically and mechanically coupled to the device converter circuit board; anda surface mount emulator foot secured to the device converter circuit board, the surface mount emulator foot having a developmental surface mount footprint that emulates the surface mount footprint of the target NVM, and the device converter and surface mount emulator foot fitting within the volume of the target NVM in the target system, the device converter and surface mount emulator foot provide electrical interface routing between device terminals of the at least one reprogrammable memory device ...

Water soluble polymers for agrochemical compositions

Agrochemical aqueous compositions containing at least one organic, solid agrochemically active ingredient which is insoluble in water and, as dispersing and wetting agent, a water soluble polymer based on one or more ethylenically unsaturated carboxylic acids, from 5% to 55% of the carboxylic groups of said water soluble polymer being esterified with a polyalkoxylated polystyrylphenol.

THERAPY WITH CLOSTRIDIUM PERFRINGENS ENTEROTOXIN TO TREAT OVARIAN AND UTERINE CANCER

The invention discloses high levels of receptors for enterotoxin (CPE) have been found in ovarian cancer and uterine cancer tissue samples. In addition, successful in vivo treatment of a mouse model of ovarian cancer with intraperitoneal injection of CPE is disclosed. High levels of Ep-CAM protein is also disclosed in ovarian cancer tissue samples. Thus, the invention provides a method of treating ovarian cancer and uterine cancer by administering CPE. The invention also provides a method of treating cancer in a mammal involving intraperitoneal administration of CPE, where at least some cancerous cells are located in or adjacent to the peritoneal cavity of the mammal. The invention also provides a method of treating ovarian cancer involving administering an anti-Ep-CAM antibody. The invention also provides a method of treating cancers expressing claudin-3 or claudin-4 by administering an antibody against claudin-3 and/or an antibody against claudin-4. The invention also provides a method of protecting a mammal from CPE toxicity involving administering a protective agent that binds to claudin-3 and/or claudin-4 and inhibits CPE binding to claudin-3 and/or claudin-4. 120.-. (canceled)21. A method of determining the sensitivity of a gynecological malignancy to CPE comprising:detecting the presence or absence of claudin-3 and/or claudin-4 in a tissue sample comprising a portion of the malignancy.22. The method of wherein the detecting step comprises contacting the tissue sample with a protein comprising residues 290-319 of SEQ ID NO:1 or a fragment thereof that binds specifically to claudiin-3 and/or claudin-4.23. The method of wherein the protein is CPE.24. The method of wherein the protein is an antibody comprising an Fc coupled to an antigen-binding peptide comprising residues 290-319 of SEQ ID NO:1 or a fragment thereof that binds specifically to claudin-3 and/or claudin-4.2536.-. (canceled) This application claims priority under 35 U.S.C. §120 to U.S. provisional ...

Connecting device and method for connecting a wall element in an elevator car

An elevator car has a connecting device and at least one wall element, wherein the connecting device connects the at least one wall element with a bare ceiling of the elevator car. The connecting device includes a rail element with two legs, of which a first leg bears in the mounted state against the bare ceiling and a second leg has a mounting surface for the at least one wall element. The mounting surface has a first hole for suspending the at least one wall element. The at least one wall element has a suspension element at an edge which faces upwardly in the mounted state for engaging into the first hole of the connecting device.

Analytical system for the preparation of biological material

The present invention relates to a system for the isolation of biological material, using binding particles for the separation and/or isolation of such material. More precisely, the present invention relates to a system for the isolation of biological material comprised in a fluid sample, said system comprising • a separation station (1) constructed and arranged to separate and purify said biological material from said fluid sample, said separation station comprising at least one receiving vessel (2) • a reservoir (3) containing a suspension of binding particles (4) for the isolation of said biological material • a pipetting device (5) comprising a pipettor (6) for transferring said suspension of binding particles • a measuring device (7) for determining the relative or absolute quantity of said binding particles or a portion thereof within said pipettor. The present invention further provides a method for the isolation of biological material comprised in a fluid sample.

Copolymer assay

The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.

Copolymer assay

The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.

Copolymer assay

Copolymer assay

The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.

Copolymer assay

The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.

Copolymer Analysis

Copolymer assay

Copolymer assay

The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.

Copolymer assay

Copolymer assay

The present invention provides methods and compositions for evaluating one or more properties of an amino acid copolymer.

Copolymer Analysis

Un método para evaluar una propiedad de acetato de glatiramer, comprendiendo el método: (a) proporcionar al menos una célula mieloide; (b) poner en contacto al menos una célula mieloide con una cantidad de acetato de glatiramer e IFN-γ a una concentración y un periodo de tiempo suficiente para inducir que la célula exprese una o más proteínas inducidas por IFN-γ seleccionadas del grupo que consiste en: proteína 10 inducible por interferón- &gamma: (IP-10), quimioatrayente-α de células T inducible con interferón (I-TAC) y monocina inducida por interferón-γ (MIG) y (c) detectar la proteína inducida seleccionada del grupo que consiste en: proteína 10 inducible por interferón- γ (IP- 10), quimioatrayente-α de células T inducible con interferón (I-TAC) y monocina inducida por interferón-γ (MIG) para evaluar una propiedad de acetato de glatiramer. A method of evaluating a glatiramer acetate property, the method comprising: (a) providing at least one myeloid cell; (b) contacting at least one myeloid cell with a quantity of glatiramer acetate and IFN-γ at a concentration and a period of time sufficient to induce the cell to express one or more IFN-γ-induced proteins selected from the group that Consists of: interferon- & gamma-inducible protein 10: (IP-10), interferon-inducible T-cell chemoattractant-α (I-TAC) and interferon-γ-induced monokin (MIG) and (c) detecting the selected induced protein from the group consisting of: interferon-γ-inducible protein 10 (IP-10), interferon-inducible T-cell chemoattractant-α (I-TAC) and interferon-γ-induced monokin (MIG) to evaluate a property of glatiramer.

Prosthesis for the treatment of urinary incontinence

The present invention refers to a prosthesis (1) to be used for surgical therapy of female urinary incontinence and urogenital prolapse. Said prosthesis comprises a synthetic or biologic non-reabsorbable or partially reabsorbable mesh (9) and positioning means originating from said mesh (9) and comprising self-locking absorbable or non-absorbable threads (3, 3′), which in combination remarkably reduce the material used, which is subsequently left inside the patient.

Cmc combustor panel attachment arrangement

A combustor liner assembly includes a first liner panel that has a first forward end and a first aft end. A second liner panel has a second forward end and a second aft end. A support band has a plurality of circumferentially spaced holes. The support band is arranged between the first liner panel and the second liner panel. The support band has a protrusion with a first angled surface and a second angled surface. The first angled surface is in engagement with the first aft end and the second angled surface in engagement with the second forward end.

Therapy with clostridium perfringens enterotoxin to treat ovarian and uterine cancer

The invention discloses high levels of receptors for Clostridium perfringens enterotoxin (CPE) have been found in ovarian cancer and uterine cancer tissue samples. In addition, successful in vivo treatment off a mouse model of ovarian cancer with intraperitoneal injection of CPE is disclosed. High levels of Ep-CAM protein is also disclosed in ovarian cancer tissue samples. Thus, the invention provides a method of treating ovarian cancer and uterine cancer by administering CPE. The invention also provides a method of treating cancer in a mammal involving intraperitoneal administration of CPE, where at least some cancerous cells are located in or adjacent to the peritoneal cavity of the mammal. The invention also provides a method of treating ovarian cancer involving administering an anti-Ep-CAM antibody. The invention also provides a method of treating cancers expressing claudin-3 or claudin-4 by administering an antibody against claudin-3 and/or an antibody against claudin-4. The invention also provides a method of protecting a mammal from CPE toxicity involving administering a non-toxic protective agent that binds to claudin-3 and/or claudin-4 and inhibits CPE binding to claudin-3 and/or claudin-4.

Monitoring of supporting means in an elevator system

The invention relates to an elevator, comprising an elevator car, a counterweight, a drive and a supporting means, wherein the supporting means couples the elevator car and the counterweight to the drive such that the elevator car and the counterweight can be moved vertically in opposite directions by means of the drive, and wherein the supporting means has a supporting means section on the car side and a supporting means section on the counterweight side. The elevator further comprises a sensor cord which is coupled both to the elevator car and to the counterweight and which is guided such that it remains tensioned with a substantially constant tensile load when the elevator car and the counterweight move in opposite directions. The elevator further comprises a sensor, which is coupled to the sensor cord such that a slackening of a supporting means section can be detected by the sensor.

Liquid dispensing device

Disclosed is a device useful for antiseptically cleansing a surface, for example an area of a patient prior to an operation. The device includes a sponge mounted on a nozzle which extends from a hollow handle which contains an antiseptic solution. The antiseptic solution within the handle is dispensed into the sponge when a rupturable joint in the nozzle is broken.

Data strobe multiplexer

Devices and techniques are disclosed herein for determining, using a host device, a timing relationship between a data strobe signal, such as from an embedded MultiMediaCard (eMMC) device, and an internal clock signal. The host device can control a delay circuit using the determined timing relationship, such as to align received read data for sampling, or to determine or adjust a delay value of the delay circuit.

Containers and methods for the automated handling of a liquid

The invention relates to a method for the automated handling of a fluid biological sample in an analytical instrument. This method comprises providing on an analytical instrument a container having a cup portion held in a receptacle and having an opening as well as a cap portion comprising a cover closing said opening and being permanently attached to one side of said cup portion and a handling head. During automated operation, the handling head approaches said container to a side of said container having a closure by which said cover is vertically and reversibly fixed for closing said opening and horizontally asserts pressure on said closure to release said cover from said vertical and reversible fixation, and optionally raising said cover by raising said handling head to open said cup portion. Furthermore, the invention provides containers as well as instruments and systems suitable for the automated handling and processing of the fluid biological sample and discloses production methods for the manufacture of said vessels.

Containers and methods for the automated handling of a liquid

The invention relates to a method for the automated handling of a fluid biological sample in an analytical instrument. Furthermore, the invention provides containers as well as instruments and systems suitable for the automated handling and processing of the fluid biological sample and discloses production methods for the manufacture of the containers.

Stimulation of the immune response by human dendritic cell manipulation

A method for preparing human dendritic cells containing antigens by pulsing human dendritic cells with cationic liposomes comprising at least one antigen to obtain antigen pulsed human dendritic cells is disclosed. Additionally, a method of producing antigen specific human CD8+ cytotoxic T-lymphocytes (CTL) and CD4+ helper T-lymphocytes by incubating human T-lymphocytes with the antigen pulsed human dendritic cells produced by the disclosed method under conditions that promote the generation of antigen-specific T-lymphocytes with specificity to the antigen with which the dendritic cells were pulsed is disclosed. Use of the antigen pulsed dendritic cells in immunotherapy and for prophylactic vaccination also is disclosed. Additionally, use of the stimulated antigen specific human CD8+ cytotoxic T-lymphocytes (CTL) and CD4+ helper T-lymphocytes in adoptive immunotherapy and for prophylactic vaccination is also disclosed. Compositions containing antigen pulsed human dendritic cells and/or antigen specific human CD8+ cytotoxic T-lymphocytes (CTL) and CD4+ helper T-lymphocytes produced by the methods of the present invention are also disclosed. The methods and compositions are particularly useful for stimulating the immune response against human papillomavirus (HPV) oncoproteins full-length E7 or E6 that have been associated with human cervical cancer.

Elevator car with ladder which can be removed from the inside

Advanced pitch stabilizer

A pitch stabilizer with box configuration suitable for providing stability to a rotorcraft comprising a vertical mid-plane and a fuselage; the pitch stabilizer comprising one or two pitch stabilizing assemblies, with no more than one pitch stabilizing assembly on each side of the vertical mid-plane, wherein each pitch stabilizing assembly comprises upper pitch stabilizing means, lower pitch stabilizing means and a wing tip element.

Novel immunosuppressant peptides

Connecting device and method for connecting a wall element in an elevator car

The present invention relates to an elevator car having a connecting device (1) and a wall element (10), and to a method for carrying out the connection. The elevator car according to the invention comprises a connecting device (1) for connecting at least one wall element with a raw ceiling of an elevator car (100). The connecting device (1) comprises at least one rail element (2) with two legs (3, 4), of which a first leg (3) bears in the mounted state against the raw ceiling and a second leg (4) comprises at least one mounting surface (5) for at least one wall element (10). The mounting surface (5) has at least one first recess (6) for suspending the wall element (10). The wall element (10) comprises at least one suspension element (13) at an edge (19) which faces upwardly in the mounted state for engaging into the first recess (6) of the connecting device (1).

Rolling mill for rolling hollow or, in all cases, concave rod-shaped bodies

Down conductor

A cable for at least partly channelling electrical energy generated by a flash of lightning, the cable including a plurality of concentric, annular layers, extending along a length of the cable, the layers including: an electrically conductive first layer, a middle layer surrounding the electrically conductive first layer, the middle layer including: a first at least partially conductive annular layer; a second at least partially conductive annular layer; and a substantially electrically non conductive annular layer positioned between the first at least partially conductive annular layer and second at least partially conductive annular layer, and an electrically conductive second layer surrounding the middle layer wherein the first at least partially conductive annular layer, the substantially electrically non conductive annular layer and the second at least partially conductive annular layer are simultaneously extruded during construction of the cable. 110liGlE3 112A-ASL 1l1'4&\ il6

Neural regeneration using human bone morphogenetic proteins

Methods and devices are disclosed for inducing growth of neural cells, and repairing neural defects in a mammal. The method comprises administering to said mammal at the site of neural defect, damage or depletion, an effective amount of a bone morphogenetic protein, either in admixture with a pharmaceutically acceptable vehicle, or adsorbed to a suitable matrix. The device comprises bone morphogenetic protein, optionally in combination with other factors, adsorbed on a suitable matrix and contained within an artificial nerve replacement vessel.

Elevator car with ladder removable from the interior

An elevator car with special measures for evacuation has several side walls, a floor and a ceiling, which together enclose an interior of the elevator car. The elevator car has a flap arranged on one of the side walls and a ladder for evacuating persons from the interior of the elevator car. The flap is movable between a closed state, in which the flap blocks access from the interior of the elevator car to an area behind the flap, and an open state, in which access is possible from the interior of the elevator car to the area behind the flap. The flap has a height less than the height of the side walls. In the closed state of the flap, the ladder is arranged in the area behind the flap. The ladder is removable from behind the flap and can be increased in length for the evacuation.

Rotary wing aircraft with a tail shroud

The invention is related to a rotary wing aircraft (1) with a tail rotor in a rotor duct (8) of a shroud (7). A bumper (9) projects from a lower transition region of said shroud (7), said lower transition region having a left hand and a right hand lower transition edge between respectively the left hand and the right hand annular surface (57) around the rotor duct (8) and the bumper (9). Upper leading edges (12, 32) of a vertical fin (6) and of said shroud (7) are provided with left hand and right hand trailing edges (13, 17). A projection of the upper transition edge (11a) to an upright longitudinal plane is defined by a spline curve through points Pi (i=1..5) and a projection of the lower transition edge (11b) to the plane is defined by a spline curve through points Pi (1=6..10) defined by their respective coordinates (xi, zi) relative to a centre of the shrouded tail rotor.

Water soluble polymers for agrochemical compositions

Agrochemical aqueous compositions containing at least one organic, solid agrochennically active ingredient which is insoluble in water and, as dispersing and wetting agent, a water soluble polymer based on one or more ethylenically unsaturated carboxylic acids, from 5% to 55% of the carboxylic groups of said water soluble polymer being esterified with a polyalkoxylated polystyrylphenol.

Acoustic attenuation device for sound propagated along an air path

Dye dispensing system

An apparatus for dye dispensing is disclosed herein. The apparatus includes a controller and a tray. The tray communicates with the controller and is configured with at least one opening. At least one canister is configured with an identifier and a dye. The dye is associated with the identifier. A reader communicates with the controller. A dispenser comprises an actuator communicating with the controller and a lever arm. The lever arm is coupled to the actuator and configured with a projection. The reader, based on the identifier, identifies a selected dye in a selected canister associated with a dye formulation. When the selected canister is aligned with a dispensing area, the dispenser applies a downward force on the selected canister and dispenses the selected dye.

Methods for managing adverse events in patient populations requiring transfusion

Method for transfusion medicine to reduce adverse events in transfusion patient populations based on underlying patient physiology.

Pyridinone derivatives and their use as selective alk-2 inhibitors

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Synthetic fiber cable and elevator installation with such a synthetic fiber cable

A synthetic fiber cable has the strands of a strand layer mutually spaced apart. With the mutual spacing, the strands of the outer strand layer can move radially in the direction of the cable center and exert a radial pressure on the strands of the first inner strand layer. The radial pressure is passed on from the strands of the first inner strand layer to the strands of the second inner strand layer. The radial pressure is passed on from the strands of the second inner strand layer to the core strand. The radial pressure increases inwardly from strand layer to strand layer. The soft cable sheathing does not act as a support between the strands in circumferential direction.

ELEVATOR CABIN

A presente invenção refere-se a uma cabine de elevador (1), na qual estão previstas medidas especiais para uma evacuação. A cabine de elevador (1), que apresenta várias paredes laterais (3), um fundo (5) e um teto (7), que, juntos, circundam um espaço interno (8) da cabine de elevador (1). Além disso, a cabine de elevador apresenta uma portinhola (9) disposta em uma das paredes laterais (3), bem como uma escada (21) para evacuação de pessoas do espaço interno (8) da cabine de elevador (1). A portinhola (9) é deslocável entre um estado fechado, no qual a portinhola (9) bloqueia um acesso a partir de um espaço interno (8) da cabine de elevador (1) a uma região (19) atrás da portinhola (9), e um estado aberto, no qual a partir do espaço interno (8) da cabine de elevador (1) pode-se ter acesso à região (19) atrás da portinhola (9). A portinhola (9) apresenta, nesse caso, uma altura, que é menor do que a altura das paredes laterais (3). A escada (21) deve ser disposta na região (19) atrás da portinhola (9), a um estado fechado da portinhola (9). A escada (21) pode ser retirada da portinhola (9) e ampliada em seu comprimento para a evacuação. The present invention relates to an elevator cabin (1) in which special measures for evacuation are provided. The elevator cabin (1), which has several side walls (3), a bottom (5) and a ceiling (7), which together surround an internal space (8) of the elevator cabin (1). In addition, the elevator cabin has a hatch (9) arranged on one of the side walls (3), as well as a ladder (21) for evacuating people from the internal space (8) of the elevator cabin (1). The hatch (9) is displaceable between a closed state, in which the hatch (9) blocks an access from an internal space (8) of the elevator car (1) to a region (19) behind the hatch (9) , and an open state, in which from the internal space (8) of the elevator cabin (1) it is possible to have access to the region (19) behind the hatch (9). The hatch (9) has, in this case, a height ...

Soap bars

Water soluble polymers for agrochemical compositions.

Composiciones acuosas agroquímicas que contienen al menos un ingrediente agroquímicamente activo sólido, orgánico que es insoluble en agua y, como agente dispersante y humectante, un polímero soluble en agua basándose en uno o más ácidos carboxílicos etilenicamente insaturados, desde 5% hasta 55% de los grupos carboxílicos de dicho polímero soluble en agua se esterifican con un poliestirilfenol polialcoxilado.

Esterification process of prostaglandins and analogues thereof

The invention relates to a process for enzymatically catalyzed esterification of prostaglandins or analogues thereof.

Dye dispensing system

An apparatus for dye dispensing is disclosed herein. The apparatus includes a controller and a tray. The tray communicates with the controller and is configured with at least one opening. At least one canister is configured with an identifier and a dye. The dye is associated with the identifier. A reader communicates with the controller. A dispenser comprises an actuator communicating with the controller and a lever arm. The lever arm is coupled to the actuator and configured with a projection. The reader, based on the identifier, identifies a selected dye in a selected canister associated with a dye formulation. When the selected canister is aligned with a dispensing area, the dispenser applies a downward force on the selected canister and dispenses the selected dye.

A thrust producing unit with at least two rotor assemblies and a shrouding

Aerodynamic, blunt aft body

The invention is related to an aerodynamic blunt aft body (10) of a helicopter fuselage with two strakes (7, 8) along an aft surface (9) and/or respective left hand and right hand side fuselage surfaces (5, 6). Each strake (7, 8) is defined by first and second intersection lines (3, 4) resulting from intersections of horizontal planes (z) with the surface of the aft surface (9) or the respective left hand and right hand side fuselage surfaces (7, 8). The strakes are defined by a two or three dimensional spline (12) from the surface (2) towards the aft surface (9) inside said first and second intersection lines (3, 4) and inside the bounding box (15).

COMPOSITION CONTAINING SEQUOIA EXTRACT IN PUMPKIN OIL TO MAINTAIN PROSTATE FUNCTIONALITY

Synthetic fibre cable and lift installation with such a synthetic fibre cable

In this synthetic fibre cable (1) the strands of a strand layer are mutually spaced apart. With the mutual spacing (d1), the strands (7) of the outer strand layer (2) can move radially in the direction of the cable centre and exert a radial pressure on the strands (8, 9) of the first inner strand layer (3). The radial pressure is passed on from the strands (8, 9) of the first inner strand layer (3) to the strands (10) of the second inner strand layer (4). The radial pressure is passed on from the strands (10) of the second inner strand layer (4) to the core strand (5). The radial pressure increases inwardly from strand layer to strand layer. The soft cable sheathing (6) does not act as a support between the strands (7) in circumferential direction Ur,

Cloning and characterization of the complete mage-1 gene

The complete nucleotide and amino acid sequences of the human MAGE-1 antigen are provided. Peptides from residues of the Cterminal are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against MAGE-1 antigens. The peptides are particularly useful in methods for stimulating the immune response of individuals against MAGE-1 antigens associated with melanomas.

Process for the manufacture of striped soap and apparatus for carrying out the process.

Power transmission belt

This invention relates to a power transmission belt comprising a hydrogenated nitrile-butadiene-PEG acrylate copolymer containing a) 25% to 38% by weight, preferably 27% to 37% by weight and more preferably 29% to 36% by weight of at least one α,β-ethylenically unsaturated nitrile unit, b) 40% to 60% by weight, preferably 42% to 58% by weight and more preferably 44% to 59% by weight of at least one conjugated diene unit and c) 10% to 25% by weight, preferably 11% to 22% by weight and more preferably 12% to 20% by weight of at least one PEG acrylate unit derived from a PEG acrylate of the general formula (I) where R is hydrogen or branched or unbranched C1-C20-alkyl, preferably methyl, ethyl, butyl or ethylhexyl, n is 1 to 8, preferably 2 to 8, more preferably 2 to 5 and most preferably 3 and R1 is hydrogen or CH3-, where the hydrogenated nitrile-butadiene-PEG acrylate copolymer, if n is 1, does not contain any further copolymerizable monomer unit having a free carboxylic acid group.

Device for reducing fan-generated noise

The present invention relates to a device (10) for reducing fan-generated noise, comprising: a plurality of grid elements (201, 902) identifying a main development plane, and empty portions (202) delimited by the grid elements (201, 902) and configured for the passage of an air flow through the device (10), wherein each of the grid elements (201, 902) comprises a respective inner cavity (501, 903) delimited by side walls, the side walls defining at least one tube opening (401) facing a respective one of the empty portions (202) and substantially orthogonal to the main development plane, the inner cavity (501, 903) being acoustic resonant for reducing the fan-generated noise. The device (10) has a substantially circular overall shape (101, 102, 103, 104) having a substantially circular outer edge (203), first grid elements (201) of the grid elements (201, 902) having their main direction of development aligned to the outer edge (203), the first grid elements (201) being tangentially arranged and aligned with each other on concentric circumferences in the substantially circular overall shape (101, 102, 103, 104).

Optimized Dynamic Routing in a network, in particular in an optical telecommunication network

A routing method for a network including a first type of nodes and a second type of nodes, in particular an optical telecommunication network including transparent codes and regenerating nodes, includes: constructing a simplified network topology including the given node, the second nodes, first paths between the given node and the second nodes and second paths between each couple of second nodes, wherein the first and second paths pass only through first nodes and have an acceptable run-through cost, and, if the given node receives a routing request specifying a destination node that is reachable only through a second node, constructing an enhanced network topology by adding to the simplified network topology the destination node and third paths between the destination node and the second nodes that pass only through first nodes and have an acceptable run-through cost; and searching for a path having the lowest run-through cost from the given node to the destination node in the enhanced network topology.

Quick release device for lifeboats

A structure of hook (100) comprises a hook (110) arranged to pass between a block configuration, where the hook (110) cannot rotate, and a unlock configuration, where the hook (110) can rotate about a first axis (x). The structure (100) comprises also a cam (120) arranged to rotate about a second axis (y), parallel to the first axis (x), to pass between a first position and a second position, said cam (120) being equipped with a arc shaped surface (121). The structure (100) also comprises an connection element (130) between the hook (110) and the cam (120), said connection element (130) being constrained to rotate about a third axis (z), parallel to the first and the second axis (x,y), and comprising a pure rolling constraint (131) configured in such a way to roll on the arc shaped surface (121), without sliding friction, when the cam (120) passes between the first position and the second position. The connection element (130) is also configured to allow a hook (110) to pass from the block configuration to the unlock configuration, when the cam (120) rotates about the second axis (y), passing from the first position to the second position, and the pure rolling constraint (131) rolls on the arc shaped surface (121).

Helicopter with cross flow fan

The invention relates to a helicopter with a fuselage (4), at least one engine, a roll axis, at least one main rotor, and at least one housing (2) mounted to said fuselage (4). An air inlet (8) and an air outlet (7) are provided along at least a part of a circumference of the at least one housing (2), said air inlet (8) and said air outlet (7) being formed by angularly offset and separate gaps between an inside segment (33) and an outside segment (34) essentially extending respectively longitudinally in direction of said roll axis. At least one rotatable compressor (1) with a plurality of airfoil blades (6) is provided radial inside said at least one housing (2) between said air inlet (8) and said air outlet (7), said at least one rotatable compressor (1) being drivable by said at least one engine about a fan axis (5) and each chord of said airfoil blades (6) is essentially radial oriented with regard to said fan axis (5).

System and method for the automatic setup of switched circuits based on traffic prediction in a telecommunications network

An optical network is configured so as to dedicate a first portion of lightpaths to high priority traffic, and leaving a second portion of lightpaths available for low priority traffic. The high priority traffic entering the high priority lightpaths is monitored. In case of detection of a burst in high priority traffic, at least of the low priority lightpaths is torn down, so as to make available network resources within the network. Then, a new temporary lightpath is set up using the available network resources, and high priority traffic is routed on the temporary lightpath.

Imager controlling destination of its output

A printer has its software controlling the selection of each of its output bins for receiving printed sheets in accordance with the type of media printed. Each type of media has its printed sheets directed to a specific output bin. An output bin may receive sheets of more than one type of media, but the printed sheets of each type of media will be directed to only one output bin or logically linked output bins.

SCREW COMPRESSOR

Peptide of human papillomavirus For use in a composition inducing human T cells

Compositions and methods for eliciting ctl immunity

Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, of CTL-inducing peptide and an adjuvant or a lipidated peptide which induces a helper T cell (HTL) response stimulate the antigen specific CTL response. Among the viral antigens to which the CTL responses are effectively induced in humans are those of hepatitis B. The CTL response may be optimized by a regimen of two or more booster administrations. Coktails of two or more CTL inducing peptides are employed to optimize epitope and/or MHC class 1 restricted coverage.

Soap bars

Dye dispensing system

A system is disclosed including at least one scanner identifying an identification associated with a receptacle. At least one dispenser is configured to dispense a first desired amount. At least one dispensing area has a measuring instrument that measures a dispensed amount and an unused amount, and associates with the identification. At least one storage device stores a program, and at least one controller which, when executing the program, is configured to receive information and associate the information with the identification. Collected data associated with the identification is recorded. A second desired amount based on at least some of the collected data in at least one file in the database is recommended. The at least one dispenser is controlled by the at least one controller based on the first desired amount or the second desired amount. The at least one dispenser is configured to dispense the second desired amount.

Methods for using a pipetting device with independently movable pipette units

The invention provides for a method of pipetting samples using a pipetting device including more than one pipetting unit. Each of the pipetting units are independently movable in Y and Z directions and includes an upper and a lower frame. Two adjacent pipetting units include a module arranged in a staggered manner in either of the respective upper and lower frames.

Pipetting device with independently movable pipette tips

Methods for age appearance simulation

Methods and systems for age appearance simulation of a consumer. The method includes receiving an image of the consumer (including a face of the consumer), determining an ethnicity of the consumer, determining an age of the patient, and determining a desired simulated age of the consumer. An altered image to represent the desired simulated age of the consumer may then be created, where altering the image includes utilizing a statistical ethnic aging model to alter at least one of a shape of the face, a color of the face, and a texture of the face. The altered image the first altered image may be provided for display to the consumer.

Flat-belt-like supporting and drive means with tensile carriers

This supporting and drive means (11) has the geometry of a belt consisting of a belt body (12) or sheathing (12) which encloses the tensile carriers (1). The running surface (16) of the belt can be flat and parallel to the belt back (13) or have trapezium- shaped or semicircular ribs (14) and grooves (15), wherein the profile of a drive pulley or of a deflecting pulley is approximately complementary to the running surface of the belt. One or more tensile carriers (1) are provided for each rib (14), wherein the tensile carriers (1) are laid or stranded alternately in Z direction and S direction.

Neural regeneration using human bone morphogenetic proteins

Methods and devices are disclosed for inducing growth of neural cells, and repairing neural defects in a mammal. The method comprises administering to said mammal at the site of neural defect, damage or depletion, an effective amount of a bone morphogenetic protein, either in admixture with a pharmaceutically acceptable vehicle, or adsorbed to a suitable matrix. The device comprises bone morphogenetic protein, optionally in combination with other factors, adsorbe d on a suitable matrix and contained within an artificial nerve replacement vessel.

Lift with balancing means

The lift (1) has a lift cabin (3), and a counter weight (4) movable back and forth in a lift shaft (2) by supporting units (7). A compensation unit (8) connects the cabin and the counter weight and compensates weight of the supporting units on a cabin side and on a counter weight side. A guiding device is provided for guiding and stabilizing the compensation unit, and has two conducting elements (15, 16) e.g. rod-shaped rollers, with linear sections that limit movement in a plane (E) stretched by the supporting and compensation units. One of the elements has a defined movable break point. The compensation unit is designed as a cable or chain. The break point is formed as a spring element or hydraulic element. The supporting elements are designed as a belt or cable.

Peptides of human papilloma virus for use in human t cell response inducing compositions

A peptide comprising an amino acid sequence derived from a human papilloma virus (HPV) protein, wherein said amino acid sequence has the ability to bind to a human Major Histocompatibility Complex Class I molecule. Its use in prophylactic or therapeutic treatment of cervical carcinoma and other HPV-related diseases.

Rolling mill for rolling hollow rod-shaped bodies or, in any case, concave

Un laminador para laminar cuerpos en forma de barra huecos o, en cualquier caso, cóncavos, comprendiendo dicho laminador una sección (10) de laminación con una pluralidad de cajas de laminación y/o matrices (11) de laminación dispuestas en sucesión para definir un eje Y de laminación, comprendiendo dicho laminador además medios de movimiento para mover un mandril (20) y una pieza en bruto hueca (21) montada sobre una porción (22) de extremo de dicho mandril (20) a lo largo de dicho eje Y de laminación y a través de dichas cajas de laminación o matrices (11) de laminación sucesivamente; caracterizado por que dichos medios de movimiento están estructurados para mover dicho mandril (20) y dicha pieza en bruto (21) a lo largo de una dirección de laminación paralela a dicho eje Y de laminación y a través de dichas cajas de laminación o matrices (11) de laminación en sucesión aplicando una tracción sobre dicho mandril (20). A rolling mill for rolling hollow or, in any case, concave bar-shaped bodies, said rolling mill comprising a rolling section (10) with a plurality of rolling stands and/or rolling dies (11) arranged in succession to define a rolling Y axis, said rolling mill further comprising moving means for moving a mandrel (20) and a hollow blank (21) mounted on an end portion (22) of said mandrel (20) along said Y axis and through said rolling stands or rolling dies (11) successively; characterized in that said moving means is structured to move said mandrel (20) and said blank (21) along a rolling direction parallel to said rolling axis Y and through said rolling stands or dies (11 ) rolling in succession applying a traction on said mandrel (20).

Flat-iron provided with a steam ejection device

NEW IMMUNOSUPPRESSIVE PEPTIDES AND METHOD FOR THE PREPARATION

Context-sensitive conversational interface

A context-aware account management system is described. The system receives a partial request and parses the partial request to identify one or more characters in the partial request. The system determines a plurality of valid requests that include the one or more characters, for instance in response to querying one or more data structures and/or generating the valid requests using a trained machine learning model. The system generates a suggested request by selecting one of the plurality of valid requests, and in some cases, by identifying valid values for variables within the selected one of the plurality of valid requests by querying one or more data structures and/or generating the valid values using a trained machine learning model. The system outputs the suggested request and receives a confirmation in response. The system performs an action indicated by the suggested request using a user account indicated by the suggested request.

Aerodynamic, blunt aft body

An aerodynamic blunt aft body ( 10 ) of a helicopter fuselage with two strakes ( 7, 8 ) along an aft surface ( 9 ) and/or respective left hand and right hand side fuselage surfaces ( 5, 6 ). Each strake ( 7, 8 ) is defined by first and second intersection lines ( 3, 4 ) resulting from intersections of horizontal planes (z) with the surface of the aft surface ( 9 ) or the respective left hand and right hand side fuselage surfaces ( 7, 8 ). The strakes are defined by a two or three dimensional spline ( 12 ) from the surface ( 2 ) towards the aft surface ( 9 ) inside said first and second intersection lines ( 3, 4 ) and inside the bounding box ( 15 ).

CERAMIC MATRIX COMPOSITES, AND THEIR PRODUCTION PROCESS BY LIQUID INFILTRATION WITH POLYMER CERAMIC PRECURSORS

Automated decisioning based on predicted user intent

A system for automated account interaction receives historical information associated with an account corresponding to a user. The historical information identifies a transaction involving the account. The system uses one or more trained machine learning models to identify an intent for the transaction at least in part by inputting the historical information to the trained machine learning models. The system uses the trained machine learning models to generate a recommended transaction at least in part by inputting the intent for the transaction to the trained machine learning models. The system outputs the recommended transaction and receives a confirmation regarding the recommended transaction.

Billet loader for extrusion presses

Pyridinone derivatives and their use as selective ALK-2 inhibitors

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Peptides of human papilloma virus for use in human T cell response inducing compositions

Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium

Provided herein are methods for treating ovarian serous papillary carcinoma by delivering Clostridium perfringens enterotoxins to ovarian tumor cells overexpressing claudin 3 or claudin 4 protein or by inhibiting the expression and function of tumor-associated calcium signal transducer 1 (TROP-1/Ep-CAM) gene or gene product. Also provided is a method of detecting ovarian serous papillary carcinoma by examining a tumor sample from the individual for gene or gene product expression levels within a group of genes and performing statistical analysis to determine those genes or gene products which are down-regulated compared to those in a normal individual.

PEPTIDES OF THE HUMAN PAPILOMAVIRUS APPLICABLE IN THE COMPOSITIONS TO INDUCE A REACTION OF THE T-LYMPHOCYTES IN MAN.

UN PEPTIDO COMPRENDE UNA SECUENCIA AMINO ACIDA DERIVADA DE LA PROTEINA DEL VIRUS DE PAPILOMA HUMANO (HPV) DONDE TAL SECUENCIA TIENE LA HABILIDAD DE ENLAZAR UNA MOLECULA DE CLASE I DE MAYOR HISTOCOMPATIBILDAD COMPLEJA HUMANA. SE DESCRIBE SU USO EN TRATAMIENTOS PROFILACTICOS O TERAPEUTICOS DE CARCINOMA CERVICAL Y OTRAS ENFERMEDADES RELACIONADAS CON EL HPV. A PEPTIDE INCLUDES AN ACID AMINO SEQUENCE DERIVED FROM THE HUMAN PAPILOMA VIRUS PROTEIN (HPV) WHERE SUCH SEQUENCE IS ABLE TO LINK A CLASS I MOLECULA OF HIGHER HUMAN COMPLEX HABIT. THEIR USE IS DESCRIBED IN PROFILACTIC OR THERAPEUTIC TREATMENTS OF CERVICAL CARCINOMA AND OTHER DISEASES RELATED TO HPV.

Process for the production of cellulose paper pulps by biodelignification of vegetable masses

Process for the production of cellulose paper pulps from vegetable masses, comprising the steps of mixing and conditioning a vegetable mass suitable to form a culture medium with an inoculum constituted of edible ligninolythic mushrooms, such as Lentinus edodes, Pleurotis Peryngii, Psajor-caju, and the like; extracting the so-obtained enzyme and adding it to the vegetable material for the production of paper pulp, mainly constituted of cultivated annual plants such as kenaf, hemp, flax, cotton and various stems and/or agricultural-industrial residues, such as cereal straws, maize stalks, and the like; conditioning and causing the mass to react; and lastly washing the mass after the biological attack, obtaining in this way a cellulose pulp to be submitted to possible mild final cooking and bleaching treatment. Apparatus for the realisation of the process, and cellulose pulps obtained by biodelignification of cultivated annual plants and/or agricultural-industrial residues.

Packet and optical routing equipment and method

A packet and optical routing equipment (2) exchanges multiplexed optical signals with other equipment in a network and exchanges branch non-packet and packet signals with client equipment. The entering branch non-packet signals are converted into electric signals by a non-packet interface (14) and supplied directly to an electric switching unit (13); the entering packet branch signals are converted into electric signals, supplied to a packet forwarding module (15) and routed to the electric switching unit (13). The electric switching unit (13) switches the electric signals toward a WDM interface (12) that converts them into optical signals at selected wavelengths that are added to the multiplexed optical signals. The entering multiplexed optical signals that should be terminated in the equipment are extracted, converted into electrical signals, and electrically switched toward the non-packet interface (14) or the packet forwarding module (15) according to whether they are of non-packet or of a packet type. The switching unit (13) is of configurable type and may switch a variable ratio of electric non-packet and packet signals according to the traffic requirements.

A block of interleaved laminar products, a package therefor and a process for realising same

Steam iron

INTEGRATED AND MODULAR SYSTEM CONSISTING OF A ROAD SAFETY BARRIER AND A SOUNDPROOFING PANEL

Fuel cell and process for its operation

Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors

Oligonucleotide microarrays were used to profile and compare gene expression patterns between uterine serous papillary carcinoma and ovarian serous papillary carcinoma or normal endometrial epithelial cells. mRNA fingerprints readily distinguish the more biologically aggressive and chemotherapy resistant USPC from OSPC or NEC. Plasminogen activator inhibitor is the most highly up-regulated gene in OSPC relative to USPC, whereas the c-erbB2 gene product (HER-2/neu) is strikingly overexpressed in USPC relative to OSPC and may therefore represent a novel diagnostic and therapeutic marker for this highly aggressive subset of endometrial tumors.

Dried pasta based on legumes and process for the production thereof

A dried pasta based on a meal comprising a pre-cooked flour of peeled legumes in an amount of at least 50% by weight of the total weight of the meal, wherein said dried pasta is free of binding agents and said legume flourhas a protein dispersability index (PDI) greater than or equal to 55.

Peptides of human papilloma virus for use in human t cell response inducing compositions

A peptide comprising an amino acid sequence derived from a human papilloma virus (HPV) protein, wherein said amino acid sequence has the ability to bind to a human Major Histocompatibility Complex Class I molecule. Its use in prophylactic or therapeutic treatment of cervical carcinoma and other HPV-related diseases.

Elevator

Apparatus to disconnect and restore a secondary electric power network

Dye dispensing system

A system is disclosed including at least one scanner identifying an identification associated with a receptacle. At least one dispenser is configured to dispense a first desired amount. At least one dispensing area has a measuring instrument that measures a dispensed amount and an unused amount, and associates with the identification. At least one storage device stores a program, and at least one controller which, when executing the program, is configured to receive information and associate the information with the identification. Collected data associated with the identification is recorded. A second desired amount based on at least some of the collected data in at least one file in the database is recommended. The at least one dispenser is controlled by the at least one controller based on the first desired amount or the second desired amount. The at least one dispenser is configured to dispense the second desired amount.

Pyridinone derivatives and their use as selective alk-2 inhibitors

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

LAMINATE FOR THE LAMINATION OF ASTIFORM ELEMENTS CABLES OR OTHERWISE CONCAVES

Production of cyanopyridines

Flat belt-like supporting and driving means with tension members

The drive unit (11) has two tensile carriers (1) extending at a spacing from one another axially parallel to a longitudinal axis of the drive unit and embedded in a sheathing (12). Each of the tensile carriers includes strands arranged in one strand layer, where each strand is formed from stranded threads, which are embedded in a matrix material and constructed from synthetic fibers, for improved connection between the sheathing and the matrix material. A Shore hardness of the sheathing is approximately equal to a Shore hardness of the matrix material.