28-01-2021 дата публикации
Номер: US20210024525A1
Автор:
Alam Md Rauful,
Amedzo Lukiana,
Babu Suresh,
Baiazitov Ramil Y.,
Barraza Scott J.,
Bhattacharyya Anuradha,
Karp Gary Mitchell,
Kenton Nathaniel T.,
Mazzotti Anthony R.,
Moon Young-Choon,
Mszar Nicholas W.,
Narasimhan Jana,
Pal Sudipta,
Patel Jigar S.,
Sydorenko Nadiya,
Turpoff Anthony,
Woll Matthew G.,
Xu Zhenrong,
Zhang Nanjing
Принадлежит:
The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. 2. The compound of claim 1 , wherein X is selected from NRand a bond.3. The compound of claim 1 , wherein B is heterocyclyl selected from azetidinyl claim 1 , tetrahydrofuranyl claim 1 , pyrrolidinyl claim 1 , piperidinyl claim 1 , piperazinyl claim 1 , 1 claim 1 ,4-diazepanyl claim 1 , 1 claim 1 ,2-dihydropyridinyl claim 1 , 1 claim 1 ,2 claim 1 ,5 claim 1 ,6-tetrahydropyridinyl claim 1 , 1 claim 1 ,2 claim 1 ,3 claim 1 ,6-tetrahydropyridinyl claim 1 , hexahydrocyclopentapyrrol-(1H)-yl claim 1 , hexahydropyrrolo[3 claim 1 ,2-b]pyrrol-(2H)-yl claim 1 , hexahydropyrrolo[3 claim 1 ,4-b]pyrrol-(2H)-yl claim 1 , (3aS claim 1 ,6aS)-hexahydropyrrolo[3 claim 1 ,4-b]pyrrol-(2H)-yl claim 1 , hexahydropyrrolo[3 claim 1 ,4-b]pyrrol-(1H)-yl claim 1 , (3aS claim 1 ,6aS)-hexahydropyrrolo[3 claim 1 ,4-b]pyrrol-(1H)-yl claim 1 , (3aR claim 1 ,6aR)-hexahydropyrrolo[3 claim 1 ,4-b]pyrrol-(1H)-yl claim 1 , hexahydropyrrolo[3 claim 1 ,4-c]pyrrol-(1H)-yl claim 1 , (3aR claim 1 ,6aS)-hexahydropyrrolo[3 claim 1 ,4-c]pyrrol-(1H)-yl claim 1 , octahydro-2H-pyrrolo[3 claim 1 ,4-c]pyridinyl claim 1 , octahydro-5H-pyrrolo[3 claim 1 ,2-c]pyridinyl claim 1 , octahydro-6H-pyrrolo[3 claim 1 ,4-b]pyridinyl claim 1 , (4aR claim 1 ,7aR)-octahydro-6H-pyrrolo[3 claim 1 ,4-b]pyridinyl claim 1 , (4aS claim 1 ,7aS)-octahydro-6H-pyrrolo[3 claim 1 ,4-b]pyridinyl claim 1 , hexahydropyrrolo[1 claim 1 ,2-a]pyrazin-(2H)-one claim 1 , hexahydropyrrolo[1 claim 1 ,2-a]pyrazin-(1H)-yl claim 1 , (7R claim 1 ,8aS)-hexahydropyrrolo[1 claim 1 ,2-a]pyrazin-(1H)-yl claim 1 , (8aS)-hexahydropyrrolo[1 claim 1 ,2-a]pyrazin-(1H)-yl claim 1 , (8aR)-hexahydropyrrolo[1 claim 1 ,2-a]pyrazin-(1H)-yl claim 1 , hexahydro-1H-cyclobuta[1.2-c:1 claim 1 ,4-c′]dipyrrol-(3H)-yl claim 1 , (8aS)-octahydropyrrolo[1 claim 1 ,2-a] ...
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