Use of tyrosine kinase inhibitors for treatment of cushing's disease and hypercortisolism

The invention relates to methods and kits for the treatment of, prevention of, and lowering the chances of developing Cushing's Disease and/or hypercortisolism by the administration of a tyrosine kinase inhibitor, such as gefitinib.

Videos for In Application Purchases and Rewards for Sharing Same through Social Media and Video Advertising for Reengagement

The present invention is directed to the systems, computer program products, methods and devices that encourage users of applications for mobile devices to watch and/or to share videos. In some embodiments, users are provided with the opportunity to purchase goods or services in exchange for having viewed a video within the context of an application. These users may also be provided with the opportunity to purchase goods or services in exchange for sharing the videos through social media. Alternatively od additionally, they may be presented with opportunities for reengaging applications that they previously used but for which they have decreased the frequency with which they use those applications or have ceased using those applications.

Methods and devices for neuromodulation of the adrenal gland

Aspects of the present disclosure are directed toward apparatuses, systems, and methods for delivering therapy to an adrenal gland of a patient. The apparatuses, systems, and methods may include a housing and a plurality of electrodes arranged with the housing. In addition, one or more of the plurality of electrodes may deliver stimulation energy to modulate L-dopa release.

Methods and systems of optical inspection of electronic device manufacturing machines

Implementations disclosed describe an inspection device capable of being transferred by a robot blade into a processing chamber of a manufacturing machine, the inspection device comprising an optical sensor to detect light reflected from a target located within the processing chamber, wherein the optical sensor is to output, to a processing device, a signal representative of a state of a region of a surface of the target.

Photovoltaic system and associated use

For the economical and energy-efficient use of a PV system having upright, in particular bifacial, PV modules and to substantially avoid shading of the PV modules, a supporting structure which is simple to manufacture and install is provided, that is constructed by vertical posts, which are connected to one another at intersecting points, and horizontally running cross-members such that rectangular mounting areas are provided for the individual PV modules. The posts and cross-members are formed in a material-saving manner by conventional profiles, and a division of the posts into two interconnectable sections substantially facilitates the assembly. An electrical connection is provided such that active surfaces which are arranged one above another can be operated at different electrical operating points and such that electrical lines are formed which are operated separately from one another and are arranged in a horizontally running manner. This minimizes effects of shading of PV modules on the efficiency of the energy conversion.

Steering of Target Poles in an Electrode Array in a Pulse Generator System

Techniques for steering of target poles formed by implantable electrodes in a stimulator device are disclosed. The steering technique modifies the relative amplitude of target poles once they are steered to an electrode array boundary. Once a target pole is steered to an electrode array boundary, further steering in the direction of that boundary results in a gradual decrease in the relative amplitude of that target pole. Eventually, continued steering in that direction will cause that target pole to disappear. Thus, in the case of a target tripole, continued steering will eventually cause the target tripole to be automatically converted into a target bipole. In another example of steering, target poles defined linearly in one direction can be split in an orthogonal direction to create a target pole configuration that is two-dimensional.

Methods and systems for stimulation for glial modulation

A system for planning or conducting stimulation includes a display; and a processor that executes instructions configured for: displaying, on the display, a representation of a stimulation effect; obtaining and displaying, on the display, a path for migration of the stimulation effect; receiving a duration or rate for migration of the stimulation effect; and determining a selection of one of more electrodes or optical stimulators for one or more stimulation leads of a stimulation system to produce the stimulation effect and conduct the migration of the stimulation effect along the path according to the duration or rate.

Directional electrical stimulation leads and systems for spinal cord stimulation

An implantable electrical stimulation lead can be used for spinal cord stimulation. Leads with segmented electrodes can be used to provide both medial and lateral stimulation. Multiple leads with segmented electrodes can provide paddle-like stimulation. Leads with bent distal portions can facilitate stimulation of multiple elements of the spinal cord and associated anatomy such as, for example, the dorsal column, dorsal, horn, dorsal root ganglia, and the like.

Methods and systems for stimulation for glial modulation

A system for planning or conducting stimulation includes a display; and a processor that executes instructions configured for: displaying, on the display, a representation of a stimulation effect; obtaining and displaying, on the display, a path for migration of the stimulation effect; receiving a duration or rate for migration of the stimulation effect; and determining a selection of one of more electrodes or optical stimulators for one or more stimulation leads of a stimulation system to produce the stimulation effect and conduct the migration of the stimulation effect along the path according to the duration or rate.

Separation device

There are provided carbon membranes for use in separation processes. These have a very narrow range of pore sizes, with a very sharp cutoff at the upper pore size, and thus they are suited for the separation of various constituents which differ but little in their size. The membranes can be of a varied configuration: sheet form, tubular form, assymetrical membranes and the like. There is provided a process for the production of such membranes by controlled pyrolysis of a carbon containing percursor material.

Prepolymerization process

Ｌｃｄパネル用にグラフィックス画像を拡張する方法および装置

(57)【要約】 （修正有） 【課題】 低解像度のグラフィックスデータを、高解像 度ＬＣＤパネルディスプレイ上にスケールアップして非 ネイティブの解像度で表示する際、処理能力や消費電力 を悪化させずに補間を行う方法および装置の提供。 【解決手段】 固定解像度パネルディスプレイに対する 複数のグラフィックス解像度のなかの少なくとも１つの 出力を制御するディスプレイコントローラであって、格 納されたグラフィックス表示データを出力する格納手段 と、格納手段に結合され、グラフィックス表示データを 少なくとも１つのグラフィックス表示解像度にスケール アップする補間手段と、格納手段および補間手段に結合 され、制御信号を出力する制御手段と、制御手段に結合 され、第１のクロック信号を受け取り、制御手段から出 力される制御信号を受け取り、制御信号に応答して第２ のクロック信号を出力するクロック分周手段とを備え る。

Process for producing aminodiphenylamines

Polynucleic acid encoding variant insulin-like growth factor I receptor beta subunit and receptor

The present invention provides novel IGF-I receptor subunits characterized by modified IGF-I receptor function, novel polynucleic acid sequences that encode these receptor subunits, and various applications for their use.

Organic semiconductor composition comprising liquid medium

Disclosed are a novel semiconductor composition comprising at least one organic semiconductor in a liquid medium and the use thereof the production of organic semiconductor devices, in particular organic field effect transistors, organic solar cells, light- emitting diodes and sensors.

N-fluoroalkyl-substituted dibromonaphthalene diimides and their use as semiconductor

The present invention relates to compounds of the formula (I) where R 1 and R 2 independently of each other, are selected from 1H,1H—C 2 -C 10 -perfluoroalkyl and 1H,1H,2H,2H—C 3 -C 10 -perfluoroalkyl, except for the compound of formula (I), where R 1 and R 2 are both 1H,1H-perfluorobutyl, and to their use, especially as an n-type semiconductor.

Method for the deposition of an organic material

The present invention relates to a method for the deposition of at least one layer of an organic material on a substrate by (a) providing a source of a solid organic material in an atmosphere at a pressure comprised between 50 and 200 kPa, (b) heating said organic material to a first temperature to produce a vapor of said organic material, (c) exposing at least one surface of a substrate having a second temperature lower than said first temperature to said vapor to deposit organic material from said vapor onto said at least one surface of said substrate.

Organic semiconductor composition comprising a liquid medium

Disclosed are a novel semiconductor composition comprising at least one organic semiconductor in a liquid medium and the use thereof the production of organic semiconductor devices, in particular organic field effect transistors, organic solar cells, light-emitting diodes and sensors.

Liquidity analysis system and method

A liquidity analysis system and method are disclosed for monitoring, analyzing and reporting on liquidity generated in a market or in a market center. The reports generated by the liquidity engine may be used for many differing purposes, including analyzing the effectiveness of market makers, the proportionate re-distribution of market data fees or as the basis for a liquidity generation financial incentive program.

Liquid crystal mixtures

The invention relates to liquid crystal mixtures and oligomers or polymers which can be obtained by oligomerization or polymerization of the liquid crystal mixtures according to the invention, to a method for printing or coating substrates by applying and subsequently polymerizing the liquid crystal mixtures according to the invention and to the use of the liquid crystal mixtures according to the invention or the oligomers or polymers according to the invention for producing optical or electro-optical components. The invention further relates to the use of the liquid crystal mixtures according to the invention, which comprise at least one chiral dopant for producing heat insulating layers and to said heat insulating layers.

Polymerizable chiral compounds comprising 2,6-naphthyl and isomannitol units, and use thereof as chiral dopants

The present invention relates to compounds of the general formula I in which the variables are each defined as follows: W is a (Y 4 -T 2 -) s (Y 3 -A 2 -) t Y 2 —Z 2 moiety, Z 1 , Z 2 are each independently unreactive radicals as defined more specifically in the description or reactive radicals through which polymerization can be brought about, A 1 , A 2 are each independently spacers as defined more specifically in the description, Y 1 to Y 5 are linking units as defined more specifically in the description, Y 6 is a chemical single bond or —CO—, T 1 , T 2 are each independently, as defined more specifically in the description, divalent saturated or unsaturated, optionally substituted and optionally fused iso- or heterocyclic radicals, Q is substituents as defined more specifically in the description, r, t are each independently 0 or 1, s is 0, 1, 2 or 3 and q is 0, 1, 2, 3 or 4. The invention further relates to a liquid-crystalline composition which comprises at least one compound of the formula I, and to the use of the compounds of the formula I as chiral dopants.

Thermally insulating films and laminates

Liquid-crystalline mixtures

The present invention describes liquid-crystalline mixtures, and also oligomers or polymers which are obtainable by oligomerizing or polymerizing the inventive liquid-crystalline mixtures, a process for printing or coating substrates by applying and then polymerizing the inventive liquid-crystalline mixtures and the use of the inventive liquid-crystalline mixtures or of the inventive oligomers or polymers for production of optical or electrooptical components. The present invention further relates to the use of the inventive liquid-crystalline mixtures which comprise at least one chiral dopant for production of thermal insulation layers, and to such thermal insulation layers.

Polymerizable chiral compounds containing 2,6-naphthyl- and isomannite units, and use thereof as chiral dopants

The present invention relates to compounds of the general formula (I) in which the variables have the following meaning: W is a grouping (Y 4- T 2- ) s (Y 3 -A 2- ) t Y 2 -Z 2 , Z 1 , Z 2 are non-reactive radicals of reactive radicals for promoting polymerization independent of one another as defined more precisely in the description, A 1 , A 2 are spacers independent of one another as defined more precisely in the description, Y 1 through Y 5 are linking units as defined more precisely in the description, Y 6  is a single chemical bond or -CO-, T 1 , T 2 are bivalent saturated or unsaturated, optionally substituted and optionally fused iso- or heterocyclic radicals independent of one another as defined more precisely in the description, Q indicates substituents as defined more precisely in the description, r, t are 0 or 1 independent of one another, s is 0, 1, 2 or 3 and q is 0, 1, 2, 3 or 4. The invention further relates to a fluid-crystalline composition that comprises at least one compound of the formula (I) and the use of the compounds of formula (I) as chiral dopants.

Thermally insulating films and laminates

The present invention relates to films and laminates which shield thermal radiation and are based on IR-reflective liquid-crystalline layers, to a process for the production thereof, to pigments comprising them and to a composition which comprises a particular chiral dopant.

Shielded fluorescent signs

A sign includes fluorescent pigment-containing indicia protected from fading from solar ultraviolet radiation by a transparent, ultraviolet-absorbing shield spaced apart therefrom. An artificial source of ultraviolet radiation is interposed between the indicia and the shield, and permits excitation of the fluorescence for nightime use of the sign.

Organic semiconductor composition comprising liquid medium

DEVICE AND METHOD FOR CORRECTING SPATIAL AND MASKING ERRORS APPEARING IN A TELEVISION IMAGE

L'INVENTION CONCERNE UN DISPOSITIF ET UN PROCEDE DE CORRECTION D'ERREURS SPATIALES ET DE MASQUAGE APPARAISSANT DANS UNE IMAGE DE TELEVISION. CE DISPOSITIF PERMET DE SELECTIONNER L'ETENDUE DES POINTS DE DONNEES A CORRIGER, D'EXTRAIRE D'UNE MEMOIRE DES DONNEES A CORRIGER, DE CORRIGER CES DONNEES, PUIS DE LES RENVOYER EN MEMOIRE, AUX MEMES ADRESSES. DOMAINE D'APPLICATION: TRAITEMENT DE SIGNAUX DE TELEVISION EN COULEURS. THE INVENTION RELATES TO A DEVICE AND A PROCESS FOR CORRECTING SPATIAL ERRORS AND MASKING APPEARING IN A TELEVISION IMAGE. THIS DEVICE ALLOWS THE SCOPE OF THE DATA POINTS TO BE CORRECTED TO BE SELECTED, TO EXTRACT FROM A MEMORY DATA TO BE CORRECTED, TO CORRECT THIS DATA, THEN TO RETURN THEM IN MEMORY, TO THE SAME ADDRESSES. FIELD OF APPLICATION: PROCESSING OF COLOR TELEVISION SIGNALS.

Improvements to railway car chassis

GENERAL BALANCING DEVICE FOR AXIAL OR BARREL MOTORS

IMPROVEMENTS TO AXIAL VOLUMETRIC MACHINES

L'invention concerne une machine à barillet, qui peut être notamment un moteur thermique. L'embiellage du moteur à barillet comporte deux butées roulantes radiales constituées par les cônes 20, 13 et 66, 67. 20 et 67 sont des cônes fixes. 13 et 66 sont portés par l'assiette inclinée 5, 6, qui tourne autour de l'axe x - x'. Application : maintien rigoureux du centrage et contrôle absolu de la position de fin de course des pistons. The invention relates to a barrel machine, which may in particular be a heat engine. The crankshaft of the barrel motor comprises two radial rolling stops formed by the cones 20, 13 and 66, 67. 20 and 67 are fixed cones. 13 and 66 are carried by the inclined plate 5, 6, which rotates around the axis x - x '. Application: rigorous maintenance of centering and absolute control of the end position of the pistons.

DISTRIBUTION DEVICE FOR AXIAL MOTOR

DISPOSITIF DE DISTRIBUTION POUR MOTEUR AXIAL COMPRENANT POUR CHAQUE SOUPAPE UN RESSORT DE RAPPEL, UN CULBUTEUR ET UN POUSSOIR ACTIONNE PAR UNE CAME. CHAQUE CULBUTEUR 21 EST MONTE TOURILLONNANT DANS UN PORTE-CULBUTEUR 31 LUI-MEME MONTE COULISSANT SUIVANT UNE DIRECTION PERPENDICULAIRE A LA TIGE DE SOUPAPE CORRESPONDANTE 53 ET DONT LA POSITION EN TRANSLATION EST OBTENUE AU MOYEN D'UN ORGANE DE REGLAGE 41 A COMMANDE EXTERIEURE SOLLICITANT LEDIT CULBUTEUR EN APPUI RESPECTIVEMENT CONTRE UN POUSSOIR 17 ET LADITE TIGE DE SOUPAPE.

Hepatoblasts and method of isolating same

This invention relates to methods of isolating hepatoblasts utilizing panning techniques and fluorescence activated cell sorting. This invention further relates to isolated hepatoblasts and to a method of treating liver dysfunction as well as to methods of forming artificial livers.

Method for Drug Screening and Characterization by Calcium Flux

The instrumentation and methods described herein are based on imaging and measuring single cell dose response by fluorescent ion imaging that records live cell responses to drug doses with no apparent damage to the cells or toxic side effects. Dose response curves and other pharmacological parameters can be computed by imaging and measuring oscillation changes for each dose and each cell. Large variability of cellular responses under the same experimental conditions indicates that pharmacological benchmarks are determined by statistical distribution of cells and cellular physiology. The instrumentation and methods described herein provide a means of measuring statistical variability of cell populations for improved screening and development methods for drugs.

Polymerized films with line texture or fingerprint texture

The present invention relates to a process for producing polymerized films with line texture or fingerprint texture or for producing substrates coated with polymerized films with line texture or fingerprint texture, to polymerized films, obtainable by this process, with line texture or fingerprint texture or substrates coated with polymerized films with line texture or fingerprint texture, to pigments obtainable by comminuting such films, to the use of such films, substrates or pigments as or in optical filter(s), polarizers, decorative media, forgeryproof markers, reflective media or for focusing light (in solar cells), to the use of such films as an antibacterial coating, to a forgeryproof marker which comprises such a film, and to a process for detecting forgeryproof markings.

2-Amino-6-anilino-purines and their use as medicaments

2-Amino-6-anilino-purine derivatives of the formula I in which the symbols are as defined in claim 1, are described. These compounds inhibit p34 cdc2 /cyclin B cdc13 kinase and protein tyrosine kinase pp60 c-src and can be used for treatment of hyperproliferative diseases, for example tumor diseases, and diseases which respond to inhibition of the activity of protein tyrosine kinase pp60 c-src , in particular osteoporosis.

Apparatus for stripping the end of an electrical conductor

Apparatus for stripping the insulation from the end of an electrical conductor (7), comprises a pair of clamping jaws (21,22) for clamping the electrical con­ ductor (7) therebetween; a pair of cutting blades (23, 24) mounted to one side of the clamping jaws (21,22) for cutting the insulation while the conductor (7) is clamped by the clamping jaws (21,22); a drive for driving the clamping jaws (21,22) and cutting blades (23,24); and displacing means driven by the drive for effecting rela­ tive movement between the clamping jaws (21,22) and cutting blades (23,24) in order to strip the cut in­ sulation from the ends of the conductor (7). The pair of cutting blades (23,24) are carried by a support pivotably mounted with respect to the clamping jaws (21,22). The displacing means pivots the cutting blades support away from the clamping jaws (21,22) to strip the cut insula­ tion from the end of the conductor (7).

Communication system, monitoring system and related methods

The present invention relates to a communication system (140), to a monitoring system (110) for in-situ monitoring of at least one substance (112), wherein the monitoring system (110) comprises the communication system (140), as well as to related methods (310, 312). The monitoring system (110) can, via the communication system (140), be used for monitoring the at least one substance (112) and to provide treatment data for treating the at least one substance (112). Herein, the communication system (140) comprises a cloud server (144), a first server (146), at least one second server (148, 148'), and at least one third server (150, 150'); wherein the first server (146) further has a first communication interface (156) configured to provide reference spectral information referring to at least one reference sample and reference analytical data to the cloud server (144); wherein each second server (148, 148') has a second communication interface (158, 158') configured to provide spectral information related to at least one substance (112) to the cloud server (144); wherein the cloud server (144) is configured to * generate a calibration model by using the reference spectral information referring to the at least one reference sample and the reference analytical data provided by the first server (146), wherein the calibration model comprises at least one parameter; * apply the calibration model to the spectral information related to the at least one substance (112) provided by the second server (148, 148'), whereby at least one value for the at least one parameter is extracted; * provide the at least one value for the at least one parameter to the first server (146) via the first communication interface (156); wherein the first server (146) is further configured to determine treatment data by using the at least one value for the at least one parameter provided by the cloud server (144), wherein the treatment data comprise at least one piece of data ...

Photovoltaic system and its application

Zur wirtschaftlichen und energieeffizienten Nutzung einer PV-Anlage (1) mit aufrecht stehenden, insbesondere bifazialen, PV-Modulen (2) und insbesondere zur weitgehenden Vermeidung von Abschattungen der PV-Module (2) wird einerseits eine sehr einfach zu fertigende und zu montierende Tragkonstruktion (3) vorgeschlagen, die durch an Kreuzungspunkten miteinander verbundene vertikale Pfosten (4) und horizontal verlaufende Riegel (5) aufgebaut ist, sodass rechtwinklige Montagefelder (6) für die einzelnen PV-Module (2) bereitgestellt werden können, wobei die Pfosten (4) und Riegel (5) vorzugsweise jeweils in materialsparender Weise durch gängige Profile (12, 22) gebildet sein können und wobei insbesondere eine Aufteilung der Pfosten (4) in zwei miteinander verbindbare Abschnitte (7), (8) die Montage insgesamt wesentlich erleichtert; zum anderen schlägt die Erfindung eine elektrische Verschaltung vor, sodass übereinander angeordnete aktive Flächen (9, 9') in unterschiedlichen elektrischen Arbeitspunkten betrieben werden können und sodass bevorzugt voneinander getrennt betriebene elektrischen Zeilen 21 gebildet sind, die vorzugsweise horizontal verlaufend angeordnet sind. Damit können die Auswirkungen von Abschattungen von PV-Modulen 2 auf die Effizienz der Energiewandlung der PV-Anlage 1 weiter minimiert werden For the economical and energy-efficient use of a PV system (1) with upright, in particular bifacial, PV modules (2) and in particular to largely avoid shading the PV modules (2), a support structure that is very easy to manufacture and assemble is required (3) is proposed, which is constructed by vertical posts (4) and horizontally running bars (5) connected to one another at intersection points, so that right-angled mounting fields (6) can be provided for the individual PV modules (2), the posts (4 ) and latch (5) can preferably each be formed in a material-saving manner by common profiles (12, 22) and in particular a division of the posts (4) into two sections ...

Thermally insulating films and laminates

Method for treating a condition with a cytokine of the GP130 subunit signaling family linked to a polynucleotide encoding SOCS-3

Disclosed is a nucleic acid construct comprising a murine SOCS-3 promoter sequence having SEQ. ID. NO.:1, or a non-murine homologue thereof, or an operative fragment or derivative. The construct can also contain, operatively linked to the SOCS-3 promoter, a gene encoding any preselected protein, and optionally contains a reporter gene to facilitate detection and/or selection of successfully transfected cells. Also disclosed are a transgenic vertebrate cell containing the nucleic acid construct and transgenic non-human vertebrates comprising such cells. The nucleic acid construct is useful in methods of treating a growth retardation or growth acceleration disorder in a human subject and in a method of treating an autoimmune disease, immune disease, or inflammatory condition in a human subject. A kit for genetically modifying a vertebrate cell includes a polynucleotide comprising the murine SOCS-3 promoter sequence is also disclosed.

Photovoltaic system

Zur wirtschaftlichen und energieeffizienten Nutzung einer PV-Anlage (1) mit aufrecht stehenden, insbesondere bifazialen, PV-Modulen (2) und insbesondere zur weitgehenden Vermeidung von Abschattungen der PV-Module (2) wird einerseits eine sehr einfach zu fertigende und zu montierende Tragkonstruktion (3) vorgeschlagen, die durch an Kreuzungspunkten miteinander verbundene vertikale Pfosten (4) und horizontal verlaufende Riegel (5) aufgebaut ist, sodass rechtwinklige Montagefelder (6) für die einzelnen PV-Module (2) bereitgestellt werden können, wobei die Pfosten (4) und Riegel (5) vorzugsweise jeweils in materialsparender Weise durch gängige Profile (12, 22) gebildet sein können und wobei insbesondere eine Aufteilung der Pfosten (4) in zwei miteinander verbindbare Abschnitte (7), (8) die Montage insgesamt wesentlich erleichtert; zum anderen schlägt die Erfindung eine elektrische Verschaltung vor, sodass übereinander angeordnete aktive Flächen (9, 9') in unterschiedlichen elektrischen Arbeitspunkten betrieben werden können und sodass bevorzugt voneinander getrennt betriebene elektrischen Zeilen 21 gebildet sind, die vorzugsweise horizontal verlaufend angeordnet sind. Damit können die Auswirkungen von Abschattungen von PV-Modulen 2 auf die Effizienz der Energiewandlung der PV-Anlage 1 weiter minimiert werden For the economical and energy-efficient use of a PV system (1) with upright, in particular bifacial, PV modules (2) and in particular to largely avoid shading the PV modules (2), a support structure that is very easy to manufacture and assemble is required (3) is proposed, which is constructed by vertical posts (4) and horizontally running bars (5) connected to one another at intersection points, so that right-angled mounting fields (6) can be provided for the individual PV modules (2), the posts (4 ) and latch (5) can preferably each be formed in a material-saving manner by common profiles (12, 22) and in particular a division of the posts (4) into two sections ...

One-piece shower base

A one-piece shower base includes a pitched bottom surface, a plurality of vertical flanges extending upward from a plurality of outer edges of the one-piece shower base, a drain integrated within the one-piece shower base, and a pitched foam support base having an upper surface and a lower surface. The pitched bottom surface is pitched downward in at least one direction toward the drain. The upper surface of the pitched foam support base is adhered to an underside of the pitched bottom surface. The pitched foam support base fills in a hollow space below the underside of the pitched bottom surface created by the pitch of the pitched bottom surface.

A tooless self closing floor grommet closure for cable openings

Air demoisturizer for oil-insulated transformers, chokes and tap changers

An air demoisturizer for an oil expansion vessel of an electrical power unit like an oil-filled transformer, tap changer or choke, has a heating element in the body of absorbent and utilizes a heat-regeneratable absorbent which is cut off by a moisture detector from the oil expansion vessel when the absorbent is saturated and is thermally regenerated. The demoisturizing column is provided in line with an oil receiver through which the dry air is passed before reaching the oil expansion vessel.

GENERAL BALANCING DEVICE FOR AXIAL OR BARREL MOTORS

SUIVANT L'INVENTION, CE DISPOSITIF D'EQUILIBRAGE GENERAL DESTINE A UN MOTEUR A BARILLET 0 A ASSIETTE PIVOTANTE 1, COMPREND: -UN CONTREPOIDS EXTERIEUR 19 LIE A UN VOLANT 20;UN CONTREPOIDS EXTERIEUR 22 LIE A UNE POULIE AVANT;-UN CONTREPOIDS INTERIEUR 14 FIXE SUR UN VILEBREQUIN 3;-ET UN CONTREPOIDS INTERIEUR 8 LIE A UNE ASSIETTE 1. APPLICATION NOTAMMENT A L'EQUILIBRAGE D'UN MOTEUR AXIAL AU MOYEN DE CONTREPOIDS. FOLLOWING THE INVENTION, THIS GENERAL BALANCING DEVICE INTENDED FOR A 0 BARREL MOTOR WITH SWIVEL PLATE 1, INCLUDES: AN EXTERNAL COUNTERWEIGHT 19 LINKS TO A WHEEL 20; AN EXTERIOR COUNTERWEIGHT 22 LINKS TO A FRONT PULLEY; 14 FIXED ON A CRANKSHAFT 3; -AND AN INTERNAL COUNTERWEIGHT 8 LINKED TO A PLATE 1. APPLICATION IN PARTICULAR TO THE BALANCING OF AN AXIAL MOTOR BY MEANS OF COUNTERWEIGHT.

Low profile drain

A low profile drain includes a first extrusion channel extending lengthwise in a first direction, a second extrusion channel extending lengthwise in the first direction, and a connection channel extending lengthwise in the first direction. The connection channel is configured to interlock with an end of the first extrusion channel via a first interlocking mechanism, and interlock with an end of the second extrusion channel via a second interlocking mechanism. The first interlocking mechanism includes at least one first angular protrusion disposed on the first extrusion channel, and a first angular recess disposed on the connection channel. The at least one first angular protrusion is configured to interlock with the first angular recess.

Detector array and a spectrometer system

A detector array (112), a spectrometer system (110) comprising the detector array (112) and various uses of the spectrometer system (110) are disclosed. The spectrometer system can be employed for various investigation or monitoring purposes, in particular in the infrared spectral region, especially in the near-infrared and the mid infrared spectral regions. Herein, the detector array (112) comprises a substrate (212); and a plurality of detector pixels (144) applied to a surface of the substrate (212), wherein each detector pixel (144) has a sensor region (214) which is designated for receiving a partition of incident light (114), wherein each detector pixel (144) is designated for generating a sensor signal depending on an intensity of the partition of the incident light (114) received by the sensor region of the detector pixel (144), wherein at least two adjacent detector pixels (144) share a single connection to a common electric potential (316), and wherein the sensor regions of at least two of the detector pixels (144) differ with respect to each other by an area (220) of the corresponding sensor region (214).

External cylindrical grinding machine - has infeed drive motor compactly housed in transverse tunnel passing under table guideways and allowing easy access from operator side of bed

There is a tunnel (34) passing transversely through the machine bed (1) under the table guideways (4). The drive motor (32) for the infeed movement of the grinding slide (22) is housed in the tunnel. A removable cover plate (49) closes off the tunnel on the opposite side of the bed. The motor (32) is endface mounted on a bracket (36) in co-axial alignment with the infeed leadscrew (28). The infeed drive embracing leadscrew, nut and motor is easily assembled and dismantled from the operator side of the bed. USE/ADVANTAGE - External cylindrical grinding machine has small depth dimension. Infeed mechanism is easily accessible for maintenance.

Patent DE2204509B2

Extensible authoring and playback platform for complex virtual reality interactions and immersive applications

An immersive video system includes a display, a sensor that provides information about a user's location relative to the display, a projector capable of projecting images onto the user, and a processor in communication with the display, the sensor, and the projector. The processor manipulates the images projected onto the user based on user location data from the sensor.

Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use

In its many embodiments, the present invention provides certain substituted amino triazolopyrimidine and amino triazolopyrazine compounds of Formula (IA) and Formula (IB): and, and pharmaceutically acceptable salts thereof, wherein, R 1 , n, R 2 , and R 3 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Shroud cooling assembly for gas turbine engine

Laser protective wall for shielding a laser area

Eine Laserschutzwand zur Abschirmung eines Laserbereiches mit zwei, einen Innenraum (3) begrenzenden Wänden, von denen eine erste Wand eine Innenwand (1) zum Arbeitsbereich und die zweite Wand eine Außenwand (2) bildet, ist so ausgebildet, dass im Innenraum (3) mindestens ein oder mehrere Sensoren (5) zur Erkennung von Nah-Infrarot-Strahlung (NIR-Strahlung) angeordnet sind, die mit einer Auswerte- und Schaltereinheit (7) zum Abschalten einer Laserquelle verbunden sind. A laser protective wall for shielding a laser area with two, an interior (3) bounding walls, of which a first wall, an inner wall (1) to the work area and the second wall forms an outer wall (2) is formed so that in the interior (3) at least one or more sensors (5) for detecting near-infrared radiation (NIR radiation) are arranged, which are connected to an evaluation and switch unit (7) for switching off a laser source.

Semi-round drain body and linear drain system including the same

A semi-round drain body includes an upper surface and a drain hole extending through the upper surface. The upper surface includes a first straight edge, a second straight edge disposed opposite to the first straight edge, a first curved edge, and a second curved edge disposed opposite to the first curved edge. The drain hole is disposed between the first and second straight edges and between the first and second curved edges. The first curved edge connects a first end of the first straight edge and a first end of the second straight edge to each other, and the second curved edge connects a second end of the first straight edge and a second end of the second straight edge to each other.

Photovoltaic system and associated use

Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes.

The present invention relates to new and useful nucleoside thiophosphoramidite, polynucleotide dithioate phosphoramidite and polynucleotide phosphorthioamidate phosphoramidite compounds as well as the processes whereby these compounds can be used for synthesizing new mononucleotides and polynucleotides having phosphorodithioate, phosphorothioamidate, phosphorothiotriesters, and phosphorothioate internucleotide linkages.

Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use

Machine learning to optimize spinal cord stimulation

An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.

Off-axis illumination overlay measurement using two-diffracted orders imaging

Metrology methods and tools are provided, which enhance the accuracy of the measurements and enable simplification of the measurement process as well as improving the correspondence between the metrology targets and the semiconductor devices. Methods comprise illuminating the target in a Littrow configuration to yield a first measurement signal comprising a −1 st diffraction order and a 0 th diffraction order and a second measurement signal comprising a +1 st distraction order and a 0 th diffraction order, wherein the −1 st diffraction order of the first measurement signal and the +1 st diffraction order of the second measurement signal are diffracted at 180° to a direction of the illumination, performing a first measurement of the first measurement signal and a second measurement of the second measurement signal, and deriving metrology metric(s) therefrom. Optionally, a reflected 0 th diffraction order may be split to yield components which interact with the −1 st and +1 st diffraction orders.

Transgenic cells transfected with pituitary tumor transforming gene (PTTG)) expression vectors and uses therefor

Described are cells transfected with expression vectors containing pituitary tumor transfer gene (PTTG) and uses therefor. The PTTG nucleic acids may be operatively linked to a vector, optionally provided with control and expression sequences, and/or may be carried by a host cell. The host cell may be a thyroid stimulating hormone (TSH)-sensitive cell transfected with an expression vector comprising a DNA segment encoding functional PTTG, wherein the cell overexpresses PTTG in response to TSH. Also described is an in vitro cell model used to study biological processes mediated by PTTG and a method for evaluating a compound for its ability to modulate PTTG expression.

Air dehumidifier for oil insulated transformers, choke coils as well as tap changers

Rocker arm for axial engine

A timing device for an axial engine comprising for each valve a return spring, a rocker arm and a push rod actuated by a cam. Each rocker arm is pivotably mounted in a rocker arm carrier which is itself mounted so that it can slide in a direction perpendicular to the corresponding valve stem and the position of which in this perpendicular direction is maintained by means of an externally controlled regulating element which actuates this rocker arm which bears on a push rod and the valve stem.

Method for the deposition of an organic material

Use of mechanical properties of cells in cancer detection methods

The technology subject of the present application generally concerns methods for in vivo or in vitro detection of cancer cells utilizing selective particle-uptake in cancer samples.

Organic semiconductor composition comprising liquid medium

Photovoltaic system and associated use

Disclosed is a PV system (1) comprising vertical PV modules, more particularly bifacial PV modules (2). In order to achieve an economical and energy-efficient use of said PV system and more particularly to prevent, to a great extent, shading of the PV modules (2), the invention proposes a support construction (3) that is easy to manufacture and assemble and that is composed of vertical posts (4) interconnected at intersection points and cross-members (5) running horizontally, so that rectangular assembly fields (6) for the individual PV modules (2) can be provided.

Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use

In its many embodiments, the present invention provides certain substituted amino triazolopyrimidine and amino triazolopyrazine compounds of Formula (IA) and Formula (IB): or and pharmaceutically acceptable salts thereof, wherein, R1, R2, and R3 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Shake slide connection

Piston-chamber machine

A tooless self closing floor grommet closure for cable openings

A floor grommet for use in building and office structures supplied with air conditioning via an under floor plenum. Specially directed flows of conditioned air from the plenum are optimized by limiting the undesired escape of air from the plenum into the space above the floor by way of leakage through floor openings (22) provided for the passage of power cables, data cables and the like. Floor grommets (23) installed in the cable openings comprise a surrounding frame (24) mounting sealing elements (40, 41, 90). The sealing elements are comprised of thin, flexible elements anchored at one end in the grommet frame and extending toward the center of the opening, from each side, to effectively close the opening against significant flow of conditioned air from the plenum below. Cables (46) passing through the grommet opening minimally deflect the flexible elements (44, 45) to limit the escape of conditioned air.

Recording media for registration purposes in electrosensitive registration devices

Method and apparatus for relieving stress in a combustion case in a gas turbine engine

A combustion case for a gas turbine engine. A typical combustion case is generally cylindrical or conical. Apertures penetrate the case, from the outer surface, through the case, to the inner surface. The apertures act as concentration points for stress. To dissipate the stress, bosses buttress the apertures, with each aperture having two bosses: one on the outer surface of the case, and another on the inner surface of the case. The invention eliminates the latter bosses. The invention dissipates stress by providing an array of T-slots on the inner surface.

Semi-round drain body and linear drain system including the same

A semi-round drain body includes an upper surface and a drain hole extending through the upper surface. The upper surface includes a first straight edge, a second straight edge disposed opposite to the first straight edge, a first curved edge, and a second curved edge disposed opposite to the first curved edge. The drain hole is disposed between the first and second straight edges and between the first and second curved edges. The first curved edge connects a first end of the first straight edge and a first end of the second straight edge to each other, and the second curved edge connects a second end of the first straight edge and a second end of the second straight edge to each other.

Turbine seal

Pressure-relief valve

The invention relates to a decompression valve for oil-cooled step switches and transformers. The inventive decompression valve comprises a valve lid which is actuated by springs and closes the non-operating valve, said springs being arranged between said valve lid and a spring lid. Said decompression valve is entirely placed in a body (18) which is embodied in the form of a pot and fixed directly to a flange (1) and provided with an output opening (26) in the pot-shaped lateral area.

Nucleoside and polynucleotide thiophosphoramidite and phosphorodithidate compounds and processes

Η παρούσα εφεύρεσις έχει σχέσιν με μία μέθοδο παρασκευής νέων και χρησίμων νουκλεότιδο θειοφωσφοραμιδιτών, πολυνουκλεότιδο φωσφοράμιδο διθειϊκών εστέρων και πολυνουκλεότιδο φωσφοροθειοαμιδικών φωσφοραμιδικών ενώσεων καθώς και με επεξεργασίες όπου οι ενώσεις αυτές δύνανται να χρησιμοποιηθούν δια την σύνθεσιν νέων μονονουκλεοτιδίων και πολυνουκλεοτιδίων τα οποία έχουν δεσμούς φωσφοροδιθειϊκού εστέρος, φωσφοροθειοαμιδικού εστέρος, φωσφοροθειοτριεστέρων και διανουκλεότιδο φωσφοροθειϊκού εστέρος.ω

Golf club construction

A golf club head and hosel construction. The head has a front face facing in the intended direction of flight of a golf ball and a sole extends rearwardly from the lower edge of the front face. The lower extremity of the front face is downwardly convex, having a central generally curved apex, and an alignment marker is disposed on the front face directly above the apex. The heel and toe portions of the rear face are provided with enlargements which border a generally vertical arched depression. The lower end of the depression terminates at the sole adjacent the lower extremity of the front face to provide a generally sharp edge capable of penetrating the turf, while the heel and toe enlargements control the penetration of the edge into the turf. The hosel which is connected to the head includes a generally sharp hosel edge facing in the direction of flight, and a generally flat surface borders the hosel edge and merges into the head. The flat surface is disposed at an acute angle with respect to the direction of flight and acts as an air foil to resist shaft deflection during swinging of the golf club.

Improvements in Street Cars.

12,398. Brill, J. A. May 31. Steps; underframing of bodies; tramcars.-To facilitate the entrance and exit of passengers, electric and other street cars of the kind to which access is obtained by steps fitted along the sides are provided with a greater number of steps than usual, without increasing the width or decreasing the seating capacity of the vehicle. To effect this, the usual wooden floor-supporting sills at the sides of the car are superseded by metallic sills of Z, L, or similar section, one of the webs of the sill being arranged in a horizontal position to serve as a step from which another step can be suspended. In the arrangement shown in Fig. 20, the side sill consists of a Z-section bar 2, 4, 3. The floor 17 is supported on planking 16 secured to the sill. The lower step 76 is hinged or rigidly attached to hangers 77 fixed to the sill. The superstructure of the car is supported on posts 53 spaced coincidently with the centres of the rows of transverse seats. The lower ends of the posts fit into sockets or bases 61 bolted to the sill and resting upon or fastened above the horizontal web 4. The ends of the seats 58 project over the horizontal web 4 of the sill, so that the width of the seating space retains its usual dimension, but the width of the flooring between the seats is lessened to accommodate the additional step. The seat panels 55 may be formed integrally with the sockets or supporting-bases of the posts, or they may be supported on the bases or on brackets 62. Between the posts the step 4 is covered by tread plates 73. The posts and seat panels are formed with grooves 60 in which the ends of curtain rods slide. The construction and fitting of the seat panels and post sockets may be variously modified. In the arrangement shown in Fig. 22, the sill consists of an angle-iron 3, 4 from which the lower step is hung as shown. The floor is supported on an angle-iron 46. Fig. 3 shows in plan the struts and crossings employed between the side sills. ...

Turbine seal

A blocker and swirl inducer hole configuration for use in connection with a high pressure turbine is described. In one embodiment, the blocker holes (50) are oriented to a 45-degree tangential angle with respect to the direction of rotation of the seal (16), which results in pre-swirling the air before being injected into the swirl cavity (52). In addition, the number of blocker holes is reduced by as much as 50% of the number of blocker holes used in the known CFM56 turbine. Further, rather than injecting the air into the first swirl cavity (22) as is known, the air is injected into a second swirl cavity(52). The combined effect of orienting the holes to the 45-degree tangential angle with respect to the direction of rotation of the seal, locating the holes to open into the second swirl cavity, and reducing the flow area by about 50%, results in an increase in blocker hole pressure ratio. Increasing the blocker hole pressure ratio results in a higher hole exit velocity which maxhnizes the cavity inlet swirl. The blocker holes therefore not only provide back-pressure, but also function as swirl-inducers. By inducing swirl into the air injected into the second swirl cavity, better turbine disk rim cooling effectiveness is provided. This result facilitates maintaining reasonable metal temperatures at increasingly severe cycle conditions without the normally expected engine performance penalties.

Belt-changing device for belt-type grinding machine - incorporates magazine containing large number of spare belts

METHOD FOR DRESSING GRINDING WHEELS.

Air de-humidifier for oil-insulated transformers, choke coils and step switches

The invention relates to an air-dehumidifier comprising a filter insert, which is configured as a housing filled with a moisture-absorbent granulate and is situated in a cylinder. A heating device is provided to regenerate the granulate. To guarantee the targeted condensation and drainage of the moisture that has been driven off in the heating process, the base of the cylinder has a special, funnel-shaped contour and consists of a material with an excellent specific thermal conductivity.

Semi-round floor drain

Connecting rod bearings for a volumetric piston chamber machine

The invention is a volumetric piston chamber machine wherein the crankpin is relieved of the inertia force and wherein a seat is constructed in a single piece adapted to act as a female part with the crank being a male part. As a result, the force distribution throughout this volumetric piston chamber engine is more uniformly distributed and offers the advantage of a smaller engine in the overall axial direction eliminating the harmful transverse stresses.

A tooless self closing floor grommet closure for cable openings

A floor grommet for use in building and office structures supplied with air conditioning via an under floor plenum. Specially directed flows of conditioned air from the plenum are optimized by limiting the undesired escape of air from the plenum into the space above the floor by way of leakage through floor openings (22) provided for the passage of power cables, data cables and the like. Floor grommets (23) installed in the cable openings comprise a surrounding frame (24) mounting sealing elements (40, 41, 90). The sealing elements are comprised of thin, flexible elements anchored at one end in the grommet frame and extending toward the center of the opening, from each side, to effectively close the opening against significant flow of conditioned air from the plenum below. Cables (46) passing through the grommet opening minimally deflect the flexible elements (44, 45) to limit the escape of conditioned air.

Drain grate

Rf oven with inverted f antenna

A radiating element for applying electromagnetic energy to a cavity. The radiating element comprises a feeding section and a grounding section, wherein the feeding section and the grounding section extend substantially within a first plane. The radiating element also includes a radiating section in electrical communication with the feeding section and the grounding section, wherein the radiating section includes at least one bend between the feeding section and a distal end of the radiating section, the at least one bend extending in a second plane different from the first plane.

Portable booklight

A book-light pack consisting of a case (24), to which are connected a battery and a long necked lighting element (20, 26)the battery is completely concealed within the case (24). A groove (62) in the case (24) is to house the neck (20) and the lighting element (26) when lighting is not required. Optionally, an electrical switch is disposed in the book-light pack, in such a configuration that when the lamp (26) and neck (20) are withdrawn, the light (26) is turned on.

Treatment of pituitary corticotroph tumors using r-roscovitine

Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use

In its many embodiments, the present invention provides certain substituted amino triazolopyrimidine and amino triazolopyrazine compounds of Formula (IA) and Formula (IB): or and pharmaceutically acceptable salts thereof, wherein, R 1 , R 2 , and R 3 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Megasonic clean with cavity property monitoring

Embodiments of megasonic cleaning chambers are provided herein. In some embodiments, a megasonic cleaning chamber includes: a chamber body defining an interior volume therein; a substrate support to support a substrate disposed in the interior volume; a supply tube comprising a transparent material configured to direct a cleaning fluid to the substrate support; a megasonic power generator coupled to the supply tube to provide megasonic power to the cleaning fluid; a megasonic transducer coupled to the megasonic power generator and the supply tube to create megasonic waves in the cleaning fluid and to form cavities in the cleaning fluid, wherein the megasonic transducer is configured to direct the megasonic waves and cavities toward the substrate support; and one or more sensors configured to generate a signal indicative of a property of the cavities in the cleaning fluid.

DISASSEMBLY FOR TRANSFORMERS REACTING COILS AS WELL AS STABLE SWITCHES ISOLATED TO OIL

Particulate matter comprising coated microparticles and uses of same in printing

The present disclosure concerns particulate matter comprising microparticles of a first material having a first physical property, the particles being coated with a layer of second material, wherein said first material is an inorganic material with a melting point that is higher than a melting point of said second material; and wherein the particulate matter is for printing objects characterized by at least said first physical property. Also disclosed herein is the use of the particulate matter as printing powder, or as an ink formulation, as well as methods of printing making use of the particulate matter or powder, and articles of manufacture prepared therefrom.

A gaming method and apparatus for motivating physical activity

The present invention relates to a method and apparatus for motivating physical activity when playing computer games. Generic physical activity of a user is monitored (eg jumping, running) to determine a physical activity value. The physical activity value is converted into a value for a game commodity, such as speed, movement, life, of a character in the computer. This motivates the user to be physically active in association with playing the computer game.

Communication system, monitoring system and related methods

Disclosed herein are a communication system, a monitoring system for in-situ monitoring of a substance used in a gas scrubbing process, and related methods. The monitoring system can be used to monitor the at least one substance and provide treatment data for treating the at least one substance. The communication system includes a cloud server, a first server, a second server, and a third server. The first and second servers respectively include first and second communication interfaces configured to provide spectral information to the cloud server. The cloud server is configured to generate a calibration model including at least one parameter; apply the calibration model to the spectral information provided by the second server, whereby at least one value for the at least one parameter is extracted; and provide the at least one value for the at least one parameter to the first server via the first communication interface.

Golf board game

A golf board game that combines simulated play through the use of a board and random outcome generating device and includes trivia questions that are integrated into the play of the game.

PTTG knockout rodent as a model to study mechanisms for various physiological phenomena, including diabetes

Disclosed is a null mutant (or knockout) rodent comprising in its germ cells an artificially induced PTTG null mutation. In some embodiments, the null mutant rodent can be generated by way of homologous recombination in an embryonic stem cell or germ cell. The inventive null mutant rodent can be used to study mammalian physiology at the cellular, tissue, and/or organismal level with respect to various phenotypes, including hyperglycemia, hypoinsulinaemia, hypoleptinemia, diabetes, chromosomal aneuploidy, premature centromere division, chromosomal damage, aberrant mitotic cellular division, thrombocytopenia, thymic hyperplasia, splenic hypoplasia, testicular hypoplasia, and female subfertility. Also disclosed is an animal model for diabetes. Also disclosed is a somatic or germ cell obtained from the null mutant rodent. Also disclosed is a cell line derived from a cell obtained from the null mutant rodent.

Hepatoblasts and method of isolating same

This invention relates to methods of isolating hepatoblasts utilizing panning techniques and fluorescence activated cell sorting. This invention further relates to isolated hepatoblasts and to a method of treating liver dysfunction as well as to methods of forming artificial livers.

Machine learning to optimize spinal cord stimulation

An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.