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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 29. Отображено 29.
04-07-2012 дата публикации

Application of exenatide acetate or analogue thereof in preparing drug for treating or preventing diabetes complicated with cerebral infarction

Номер: CN0101766811B
Автор: XUEQIN GAO, DESHUI QIAO, JUAN XU, GAO XUEQIN, QIAO DESHUI, XU JUAN
Принадлежит:

The invention discloses an application of exenatide acetate or an analogue thereof in preparing a drug for treating or preventing diabetes complicated with cerebral infarction, belonging to the field of pharmacy. The exenatide acetate or the analogue thereof can obviously improve the hemarheology index of a patient, not only effectively mitigate the diabetes manifestation of the patient, but alsoimprove a nerve function, thereby being beneficial to recovering the whole state of illness.

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Номер записи: 1
16-07-2008 дата публикации

Insulin-protamine zinc injection and method for preparing the same

Номер: CN0101219209A
Автор: DESHUI QIAO, XUEQIN GAO, QIAO DESHUI, GAO XUEQIN
Принадлежит:

The invention pertains to a pharmaceutical preparation field, and in particular relates to a zinc protamine insulin ampoule injection and a preparation method thereof. The zinc protamine insulin ampoule injection comprises insulin, isotonizing agent, antiseptic agent, pH regulator, protamine sulfate and bi-distilled water for injection, wherein, the bi-distilled water for injection contains divalent zinc salt and the concentration of zinc ion is 0.01-0.04g per100000IU of insulin. The injection of the invention has the advantages that minim zinc ion is added into the insulin to form a stable polymer, which stabilizes the insulin and has a prolonged curative effect; the invention has simple, scientific and reasonable preparation and easy manipulation. The insulin can exist in two patterns: firstly, in liquor with quick effect; secondly, combining with protamine sulfate and in precipitation with action characters of both two insulin preparations, which reduces injection time and pain caused ...

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Номер записи: 2
10-02-2010 дата публикации

Preparation method of pharmaceutical preparation and injection of exenatide acetate

Номер: CN0101642562A
Автор: QIAO DESHUI, SUN XIULI, GAO XUEQIN, CHEN HUI, XU LIANGQIN, DESHUI QIAO, XIULI SUN, XUEQIN GAO, HUI CHEN, LIANGQIN XU
Принадлежит:

The invention relates to a preparation method of pharmaceutical preparation and injection of exenatide acetate. The exenatide acetate pharmaceutical preparation is a stable liquid formulation appliedto a plurality of dosing manners. Per 100ml of the pharmaceutical preparation contains at least the exenatide acetate of 0.005-0.4g, preservative of 0.1-0.75g, appropriate amount of buffer and isotonic agent, wherein the preservative is chosen from one or two of chlorobutanol and phenethyl alcohol, with pH value of the pharmaceutical preparation being 3.0-7.0. The preparation method has the following steps: dissolving auxiliary materials of the preservative, the isotonic agent and the buffer according to prescription amount by using water for injection, and immigrating the dissolving solutioninto batching pot; taking the auxiliary solution or the water for injection to dissolve the exenatide acetate; and replenishing the water for injection to total volume and uniformly stirring; filtering the ...

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Номер записи: 3
16-07-2008 дата публикации

Pitavastatin calcium tablet and method for preparing the same

Номер: CN0101219121A
Автор: SUN XIULI, QIAO DESHUI, GAO XUEQIN, XIULI SUN, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to a pitavastatin calcium tablet and a preparation method thereof. The pitavastatin calcium tablet comprises a tablet core and a coating. The tablet core comprises components that (by weight percent): pitavastatin 1-5, sodium bicarbonate 5-16, lactose 75-85, croscarmellose sodium 3-6, bonding agent 0.1-0.4, silicon dioxide 1.5-3.0, magnesium stearate plus French chalk 0.5-4.0. The preparation method comprises that (in sequence): raw materials are weighed according to a prescription and screened by a 100-mesh or 80-mesh sieve; the pitavastatin, part of the croscarmellose sodium and the sodium bicarbonate are added gradually with equal quantity and well mixed to obtain a powder mixture; the powder mixture is added with the bonding agent, and well mixed and made into soft material; the soft material is squeezed through a 18-20-mesh sieve to obtain wet granules which are dried under the temperature of 50-70 DEG C; the dry granules are finished with a 20-mesh sieve and ...

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Номер записи: 4
27-05-2009 дата публикации

Technique for extracting mixed rhubarb and aconite

Номер: CN0101439103A
Автор: WANG TINGJUN, QIAO DESHUI, GAO XUEQIN, TINGJUN WANG, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to the blending extraction process of rhubarb and monkshood in compound Chinese medicine Xiaokening. The blending extraction process of the rhubarb and the monkshood comprises the following steps: mixed powder of the rhubarb and the monkshood is dipped in 6-15 times water for 2-8 hours; and then soak pollution is extracted twice under the assistance of microwave; after extraction liquid is centrifugal and filtered, double extractive supernatant fluids are combined and concentrated till the concentration of drug ingredients is 0.05-0.5g/ml, added with a macroporous resin column for adsorption; firstly, the macroporous resin column is washed with water, and then eluted with ethanol with gradient concentrations; ethanol eluent with 50-80 % of concentration is combined; ethanol is recycled; the blending extractive of the rhubarb and the monkshood is prepared by concentration. The blending extraction process organically combines the microwave assistance extraction process ...

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Номер записи: 5
06-04-2011 дата публикации

Method for determining content of fasudil hydrochloride

Номер: CN0102004139A
Автор: Wang Cheng, Liu Yueyue, Qiao Deshui, Gao Xueqin
Принадлежит:

The invention relates to a method for determining content of fasudil hydrochloride, comprising the following steps: using a potentiometric titrator to dissolve the fasudil hydrochloride in a solvent, adding acid liquor the volume of which is less than or equal to 5% of the total volume to the mixture, and using a titrant to determine the content of the fasudil hydrochloride, wherein the solvent is one or a mixed solvent selected from methyl alcohol, ethanol, water, dimethyl sulfoxide and N,N-dimethylformamide; the acid liquor is the alcoholic solution or aqueous solution of a acid, the acid is one or a mixed acid selected from hydrochloric acid, acetic acid, formic acid, sulphuric acid, phosphoric acid and nitric acid; and the titrant is one or a mixed titrant selected from sodium hydroxide titrant, potassium hydroxide titrant, sodium hydroxide methyl alcohol titrant, potassium hydroxide methyl alcohol titrant, sodium hydroxide ethanol titrant and potassium hydroxide ethanol titrant. The ...

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Номер записи: 6
07-07-2010 дата публикации

Application of exenatide acetate or analogue thereof in preparing drug for treating or preventing diabetes complicated with cerebral infarction

Номер: CN0101766811A
Автор: XUEQIN GAO, DESHUI QIAO, JUAN XU, GAO XUEQIN, QIAO DESHUI, XU JUAN
Принадлежит:

The invention discloses an application of exenatide acetate or an analogue thereof in preparing a drug for treating or preventing diabetes complicated with cerebral infarction, belonging to the field of pharmacy. The exenatide acetate or the analogue thereof can obviously improve the hemarheology index of a patient, not only effectively mitigate the diabetes manifestation of the patient, but also improve a nerve function, thereby being beneficial to recovering the whole state of illness.

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Номер записи: 7
23-05-2012 дата публикации

Preparation of glimepiride raw material

Номер: CN0101486674B
Автор: XUEQIN GAO, XIAOCHENG LI, DESHUI QIAO, GAO XUEQIN, LI XIAOCHENG, QIAO DESHUI
Принадлежит:

The invention discloses a preparation method of Glimepiride raw material, which comprises the following steps in sequence: in the presence of K2CO3, a condensation reaction is carried out between a compound A: 4-[2-(3-ethyl-4-methyl-2-keto-3-pyrroline-1-formamido)-ethyl]-benzene sulfonamide and a compound B: trans-4-methyl-cyclohexyl isocyanate of the same molar weight in an organic solvent. The mass ratio of the compound A and K2CO3 is 1:0.8-0.9; the mixture synthetic fluid of a crude Glimepiride product and K2CO3 is filtered in a suction way, and then an extract is added into pure water anddissolved to form a solution. The solution is filtered for removing impurities to obtain the aqueous solution of Glimepiride; a hydrochloric acid solution is added into the aqueous solution of the Glimepiride for acidification and then a crude product is separated; acetone is added into the crude Glimepiride product and then refined, filtered in a suction manner, dried in a vacuum environment to obtain ...

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Номер записи: 8
07-07-2010 дата публикации

New use of pitavastatin calcium and drug aiming at new use

Номер: CN0101766618A
Автор: GAO XUEQIN, QIAO DESHUI, YANG JIE, XUEQIN GAO, DESHUI QIAO, JIE YANG
Принадлежит:

The invention relates to a new use of pitavastatin calcium and a drug aiming at the new use, in particular to a new use of pitavastatin calcium in preparing drugs for curing or preventing hyperlipidemia plus cerebral infarction, belonging to the pharmaceutical field. The drug contains 1-5 percent of active ingredient pitavastatin calcium by weight percent and auxiliary materials. Pitavastatin calcium can obviously improve hemorheological index of patients, can effectively relieve the hyperlipidemia manifestations of patients and can improve neurological functions, thereby being beneficial to overall restoration of the patients from illness.

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Номер записи: 9
27-04-2011 дата публикации

Method for synthesizing DP-b99

Номер: CN0102030670A
Автор: Li Wei, Qiao Deshui, Gao Xueqin
Принадлежит:

The invention relates to a method for synthesizing DP-b99, which comprises the following steps of: adding o-nitrophonol A and potassium carbonate into a solvent, dissolving, and adding 1, 2-dibromoethane to obtain B; dissolving B into a solvent, adding into an autoclave, heating to react to obtain C under the environment of palladium, carbon and hydrogen; mixing C with diisopropylamine, sodium iodide and ethyl bromoacetate in acetonitrile, and refluxing to react at 80 to 90 DEG C to obtain D; adding D into ethanol, dropwise adding the water solution of potassium hydroxide, reacting at room temperature, controlling pH value at 2-4, and eluting E; adding E into acetic anhydride containing pyridine, heating to completely react, adding diethyl ether, and precipitating to obtain F; adding sodium into ethylene glycol at room temperature, dropwise adding 1-bromooctane, heating to completely react, adding water, and extracting by using diethyl ether to obtain I; and mixing F with I, heating to ...

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Номер записи: 10
14-07-2010 дата публикации

Method for separating and measuring exenatide acetate and blended peptide therein by using liquid chromatography

Номер: CN0101776651A
Автор: GAO XUEQIN, LIN BIN, QIAO DESHUI, XUEQIN GAO, BIN LIN, DESHUI QIAO
Принадлежит:

The invention belongs to the field of analytical chemistry, in particular a method for separating and measuring exenatide acetate and blended peptide therein by using liquid chromatography, which is used for separating and measuring an exenatide acetate solution. In a chromatographic column used by the liquid chromatography, a solid phase is alkyl bonding silica gel, and a mobile phase is acetonitrile-phosphate solution, wherein a phosphate solution or a phosphate solution containing a proper amount of acetonitrile is used as a mobile phase A, the concentration of the phosphate solution is 0.01-0.1mol/L, acetonitrile or acetonitrile containing a proper amount of phosphate solution is used as a mobile phase B, and the acetonitrile is used for carrying out gradient elution. Based on volume ratio, the mobile phase B accounts for 10-90 percent of concentration gradient range of the whole mobile phase, and the concentration of the exenatide acetate solution is 0.1-5mg/ml. The exenatide acetate ...

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Номер записи: 11
30-12-2009 дата публикации

Nateglinide tablet and preparation method thereof

Номер: CN0101612133A
Автор: WANG KEYAN, CHEN HUI, XU WEI, XU LIANGQIN, QIAO DESHUI, GAO XUEQIN, KEYAN WANG, HUI CHEN, WEI XU, LIANGQIN XU, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to Nateglinide tablets and a preparation method thereof; in Nateglinide, 30-60% of filler is 3-15% of starch and 10-30% of microcrystalline cellulose, bonding agent is 1-10% of low substituted hydroxypropyl methylcellulose, disintegrant is 15-50% of sodium carboxymethyl starch, fluidizer is 0.1-5% of silica, and lubricant is 0.1-1% of magnesium stearate; the preparation method comprises the following steps: sieving raw materials for standby use; weighing Nateglinide with prescription amount, adding appropriate purified water, blending to prepare soft material, pelletizing and drying to prepare granules of main drug; evenly mixing microcrystalline cellulose, starch and part of sodium carboxymethyl starch, adding substituted hydroxypropyl methylcellulose by equivalently progressive method, evenly mixing to prepare soft material, pelletizing and drying; mixing granules of main drug with granules of accessories, adding residual sodium carboxymethyl starch, magnesium stearate ...

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Номер записи: 12
22-07-2009 дата публикации

Preparation of glimepiride raw material

Номер: CN0101486674A
Автор: LI XIAOCHENG, QIAO DESHUI, GAO XUEQIN, XIAOCHENG LI, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention discloses a preparation method of Glimepiride raw material, which comprises the following steps in sequence: in the presence of K2CO3, a condensation reaction is carried out between a compound A: 4-[2-(3-ethyl-4-methyl-2-keto-3-pyrroline-1-formamido)-ethyl]-benzene sulfonamide and a compound B: trans-4-methyl-cyclohexyl isocyanate of the same molar weight in an organic solvent. The mass ratio of the compound A and K2CO3 is 1:0.8-0.9; the mixture synthetic fluid of a crude Glimepiride product and K2CO3 is filtered in a suction way, and then an extract is added into pure water and dissolved to form a solution. The solution is filtered for removing impurities to obtain the aqueous solution of Glimepiride; a hydrochloric acid solution is added into the aqueous solution of the Glimepiride for acidification and then a crude product is separated; acetone is added into the crude Glimepiride product and then refined, filtered in a suction manner, dried in a vacuum environment to obtain ...

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Номер записи: 13
16-07-2008 дата публикации

Telmisartan dispersible tablet and method for preparing the same

Номер: CN0101219120A
Автор: XIULI SUN, DESHUI QIAO, XUEQIN GAO, SUN XIULI, QIAO DESHUI, GAO XUEQIN
Принадлежит:

The invention discloses a telmisartan dispersible tablet and a preparation method thereof. The Telmisartan dispersible tablet comprises a telmisartan, an excipient, a cosolvent, a filling agent, a disintegrating agent; a bonding agent, a lubricant and a fluidizer, wherein, the fluidizer is sodium hydroxide and meglumine and the excipient is polyvidone; surfactant and emulsifier are excluded in the telmisartan dispersible tablet. The preparation method is that: the telmisartan and auxiliary materials are screened; the telmisartan, the cosolvent, and the excipient are added into a solvent in sequence to be dissolved; then the filtrate is spray-dried to obtain principal telmisartan granules; part of the filling agent, part of the lubricant and disintegrating agent are well mixed in sequence and then added with the bonding agent, and then palletized to obtain the auxiliary material granules; other auxiliary materials are added into the principal telmisartan granules and the auxiliary material ...

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Номер записи: 14
16-06-2010 дата публикации

Two-phase isophane zinc recombinant human insulin injection and preparation method thereof

Номер: CN0101732245A
Автор: XUEQIN GAO, DESHUI QIAO, LIANGQIN XU, GAO XUEQIN, QIAO DESHUI, XU LIANGQIN
Принадлежит:

The invention relates to a two-phase isophane zinc recombinant human insulin injection and a preparation method thereof. A specification I comprises the following components in part by weight: 300,000IU of recombinant human insulin, 42 to 54g of isosmotic agent, 7.5 to 1.5g of preservative, 14.4 to 15.0g of pH regulator and 0.45 to 0.9g of protamine sulfate. A specification II comprises the following components in part by weight: 400,000IU of recombinant human insulin, 140 to 180g of isosmotic agent, 25 to 35g of preservative, 48 to 50g of pH regulator and 1.5 to 3.0g of protamine sulfate. Both preparation methods of both specifications of the two-phase isophane zinc recombinant human insulin comprise a step of mixing solution A and solution B, wherein the solution A is prepared by adding water for injection into the recombinant human insulin, the isosmotic agent, the preservative and the pH regulator for dissolving; then slowly adding an appropriate amount of water for injection with the ...

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Номер записи: 15
30-12-2009 дата публикации

Cilostazol capsule and preparation method thereof

Номер: CN0101612137A
Автор: XU WEI, CHEN HUI, WANG KEYAN, QIAO DESHUI, GAO XUEQIN, WEI XU, HUI CHEN, KEYAN WANG, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to a Cilostazol capsule and a preparation method thereof. The components comprises Cilostazol, lactose and microcrystalline cellulose as filler, hydroxypropyl methylcellulose as binding agent, Hyprolose as disintegrant, aerosil as glidant and magnesium stearate as lubricant. The preparation method is that Cilostazol is smashed into fine powder with average grain diameter of 10-15mu m followed by 100 mesh sieve, lactose, microcrystalline cellulose, hydroxypropyl methylcellulose, Hyprolose, aerosil and magnesium stearate are sieved for standby use; Cilostazol powder and 50-90% of the filler are mixed evenly, the binding agent is added for preparing into soft material, sieving is carried out for preparing wet granulation, the wet granules are dried, smashed and sieved to prepare main drug granules; the residual filler is mixed evenly, water is added fro preparing soft material, sieving is carried out for preparing wet granules, forced air drying is carried out at 60 DEG ...

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Номер записи: 16
27-04-2011 дата публикации

New purpose for compound aloes and new purpose-based medicament

Номер: CN0102028852A
Автор: Gao Xueqin, Qiao Deshui
Принадлежит:

The invention belongs to the field of pharmacy, and relates to a new purpose for compound aloes, a new purpose-based medicament, new use of the compound aloes in the preparation of medicaments for treating or preventing hyperlipidemia with cerebral infarction. The compound aloes can improve the hemorheological indexes of patients obviously, relieve the expression of the hyperlipidemia with cerebral infarction effectively, and improve the neural function, so the compound aloes are favorable for the recovery of the integral bodies of the patients from illness.

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Номер записи: 17
16-06-2010 дата публикации

Method for preparing main ester alkaloid of traditional Chinese medicine monkshood by liquid chromatography separation

Номер: CN0101732431A
Автор: GAO XUEQIN, QIAO DESHUI, YANG CHUNYAN, XUEQIN GAO, DESHUI QIAO, CHUNYAN YANG
Принадлежит:

The invention relates to a method for preparing main ester alkaloid of traditional Chinese medicine monkshood by liquid chromatography separation. The invention establishes and prepares the chromatogram by linear amplification and optimization based on chromatogram analysis, and the main ester alkaloid of traditional Chinese medicine monkshood is prepared by separation; six mono-ester diterpene alkaloids and three diester diterpene alkaloids are prepared by separating from the traditional Chinese medicine monkshood, wherein six mono-ester alkaloids are obtained by separation or the first time, the purity of the obtained alkaloids are more than 99.3%, in chromatographic columns for analyzing and preparing the chromatogram, all stationary phases are octadecylsilane chemically bonded silica, all mobile phases are organic phases-acetate buffer systems, the proportion of the organic phases to the mobile phases is 20-70%, the organic phase is methanol or acetonitrile, the acetate buffer systems ...

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Номер записи: 18
09-02-2011 дата публикации

Febuxostat dispersible tablet and preparation method thereof

Номер: CN0101966163A
Автор: KEYAN WANG, DESHUI QIAO, XUEQIN GAO, WANG KEYAN, QIAO DESHUI, GAO XUEQIN
Принадлежит:

The invention relates to a febuxostat dispersible tablet and a preparation method thereof. The febuxostat dispersible tablet comprises febuxostat as a main material and a diluent, a disintegrant, a binder, a flow aid, a lubricant and other assistants as auxiliary materials, wherein the flow aid is silicone dioxide, and the lubricant is magnesium stearate. The febuxostat dispersible tablet is prepared from the following components in percentage by weight: 5-30% of the febuxostat, 20-80% of the diluent, 5-30% of the disintegrant, 0.1-5% of the binder, 1-10% of the silicone dioxide, 0.2-5% of the magnesium stearate and 2-8% of other assistants. The febuxostat dispersible tablet prepared by adding a proper amount of auxiliary materials into crushed febuxostat has the advantages of rapid and complete drug dissolution and stable quality, is suitable for long-term storage and convenient to use, and the bioavailability of human bodies on drugs is increased so as to increase curative effect.

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Номер записи: 19
02-02-2011 дата публикации

Mix extraction process for radix astragali and rhubarb

Номер: CN0101961392A
Автор: TINGJUN WANG, DESHUI QIAO, XUEQIN GAO, WANG TINGJUN, QIAO DESHUI, GAO XUEQIN
Принадлежит:

The invention relates to a mix extraction process for radix astragali and rhubarb, which comprises the following steps: soaking the mixed powder of radix astragali and rhubarb for 2-8h in 6-15 times of water, extracting by carrying out microwave digestion on the soak solution twice, carrying out centrifugal filtration on the extract liquids, merging the supernatants in two extraction processes, concentrating until the drug concentration is 0.05-0.5 g/ml, adsorbing by adding the concentrated solution into macroporous resin columns, washing the macroporous resin columns with water, eluting the macroporous resin columns with ethanol with gradient concentrations for many times, merging the ethanol eluents of which the concentration is 50-80%, recycling the ethanol, and concentrating to obtain the mixed extract of radix astragali and rhubarb. By combining the microwave assisted extraction technique with macromolecule adsorption technique, the invention has the technical characteristics of high ...

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Номер записи: 20
20-04-2011 дата публикации

Method for synthesizing and purifying Fasudil hydrochloride

Номер: CN0102020636A
Автор: Xin Haiqiang, Qiao Deshui, Lin Bin, Li Xiaocheng, Gao Xueqin
Принадлежит:

The invention relates to a method for synthesizing and purifying Fasudil hydrochloride, comprising the following steps of: adding N,N-dimethylformamide and thionyl dichloride to 5-isoquinoline sulfonic acid to obtain a 5-isoquinoline sulfonyl chloride hydrochloride; adding the 5-isoquinoline sulfonyl chloride hydrochloride, water and sodium bicarbonate to dichloroethene to obtain a 5-isoquinoline sulfonyl chloride solution; dripping the 5-isoquinoline sulfonyl chloride solution to homopiperazine at zero DEG C to obtain a hexahydro-1-(5-sulfonyl isoquinoline)-1(H)-1,4-benzodiazepine solution; removing impurities in three steps; adjusting the pH value to be 4.5-5.5 with an acidizing fluid, extracting, and discarding an organic phase dissolved with a dipolymer impurity; adjusting the pH value to be 9.5-10.5 with alkali, extracting and discarding a water phase dissolved with homopiperazine impurities and a majority of pigments; removing the residue pigment by passing through silica gel; and ...

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Номер записи: 21
20-05-2009 дата публикации

Glimepiride tablet and preparation method thereof

Номер: CN0101433524A
Автор: SUN XIULI, QIAO DESHUI, GAO XUEQIN, XIULI SUN, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to a Glimepiride tablet and a preparation method thereof. The Glimepiride tablet comprises the components such as Glimepiride, a filling agent or a diluting agent, an adhesive and a lubricating agent, wherein the filling agent or the diluting agent is lactose, pregelatinized starch and microcrystalline cellulose; the adhesive is hydroxypropyl methylcellulose; the lubricating agent is magnesium stearate; and the components according to weight percentage are as follows: 1 to 10 percent of the Glimepiride, 20 to 35 percent of the lactose, 13 to 30 percent of the microcrystalline cellulose, 45 to 60 percent of the pregelatinized starch, 0 to 5 percent of the hydroxypropyl methylcellulose, and 0.1 to 1 percent of the magnesium stearate. The Glimepiride tablet has few ingredients and easily obtained simple auxiliary materials, the prepared tablet can be disintegrated quickly, can be completely disintegrated within 3 minutes, can achieve even dispersing state, can be dissolved ...

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Номер записи: 22
30-12-2009 дата публикации

Preparation technique of low molecular weight sodium heparin used for injection

Номер: CN0101612130A
Автор: XU LIANGQIN, WANG KEYAN, XU WEI, CHEN HUI, QIAO DESHUI, GAO XUEQIN, LIANGQIN XU, KEYAN WANG, WEI XU, HUI CHEN, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to a preparation technique of low molecular weight sodium heparin used for injection, which is implemented by using water for injection to dissolve low molecular weight sodium heparin of prescription under the aseptic condition, adding into a batching tank, additionally adding the water for injection to the total volume, formulating solution and stirring uniformly; regulating pH value to 5.5-7.0 with diluted acid or diluted alkali solution; sterilizing and filtering the solution with 0.2 mu m double-layered microfiltration membrane, bulking the feed liquor and carrying out half tamponade; freezing the feed liquor to the temperature of minus 45-minus 40 DEG C, keeping the temperature for at least 3h, controlling the temperature of a condenser at minus 50-minus 45 DEG C, starting a vacuum pump, controlling at 18-20 Pa for sublimation, controlling the plate temperature at 2-4 DEG C/h and raising the temperature to 28-32 DEG C, keeping the temperature for 3-4h, carrying ...

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Номер записи: 23
23-02-2011 дата публикации

Telmisartan dispersible tablet and method for preparing the same

Номер: CN0101219120B
Автор: DESHUI QIAO, XIULI SUN, XUEQIN GAO, QIAO DESHUI, SUN XIULI, GAO XUEQIN
Принадлежит:

The invention discloses a telmisartan dispersible tablet and a preparation method thereof. The Telmisartan dispersible tablet comprises a telmisartan, an excipient, a cosolvent, a filling agent, a disintegrating agent; a bonding agent, a lubricant and a fluidizer, wherein, the fluidizer is sodium hydroxide and meglumine and the excipient is polyvidone; surfactant and emulsifier are excluded in the telmisartan dispersible tablet. The preparation method is that: the telmisartan and auxiliary materials are screened; the telmisartan, the cosolvent, and the excipient are added into a solvent in sequence to be dissolved; then the filtrate is spray-dried to obtain principal telmisartan granules; part of the filling agent, part of the lubricant and disintegrating agent are well mixed in sequence and then added with the bonding agent, and then palletized to obtain the auxiliary material granules; other auxiliary materials are added into the principal telmisartan granules and the auxiliary material ...

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Номер записи: 24
20-05-2009 дата публикации

Method for preparing twelve kinds of composite vitamins for injection

Номер: CN0101433547A
Автор: WANG KEYAN, QIAO DESHUI, GAO XUEQIN, KEYAN WANG, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to a preparation method for a compound 12-vitamin preparation, which comprises the following steps: using glycin as filling agent, using glycocholic acid and lecithin as solubilizer, adding sodium hydroxide solution into partial water for injection containing the glycocholic acid solubilizer to prepare clarifying solution, adding the clarifying solution into the water for injection containing the lecithin solubilizer under stirring, and using hydrochloric acid solution to adjust pH to be 2.5 to 3.5; adding three vitamins, namely vitamin A palmitate, racemized alpha-tocopherol and vitamin D3, into the mixture, and using the hydrochloric acid solution to adjust the mixture to be clear under stirring; finally adding nine vitamins, namely glycin and cocarboxylase tetrahydrate, riboflavin sodium phosphate, vitamin B12, vitamin B6, vitamin C, nicotinic amide, folic acid, biotin and dexpanthenol, into the mixture, and adding balanced water for injection; and adjusting pH ...

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Номер записи: 25
16-07-2008 дата публикации

Method for producing pitavastatin calcium raw material

Номер: CN0101219991A
Автор: LI XIAOCHENG, QIAO DESHUI, GAO XUEQIN, XIAOCHENG LI, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to a method for preparing the raw materials of pitavastatin calcium, which uses an (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-5-hydroxyl-3- carbonyl-6-heptene acid ester as a beginning raw material to generate a heptenoic acid through being reduced and reacted by adding an alkali and an acid; a D-(+) benzyl methylamine is added to generate a mixture of a benzyl methylamine salt, and crystallize to separate out a (3R, 5S)-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-6- heptenoic acid D-(+) benzyl methylamine through the different solubility of the mixtures in a separating agent, and the separating agent is a mixed liquid of a methyl isobutyl ketone and an acetone or an ethanol; finally adds lye to hydrolyze and prepare the pitavastatin calcium salt. The method of the invention is selectively reduced to a pair of isomers by using a determined reduction agent, generates salt by reacting with the D-(+) benzyl methylamine and effectively separates ...

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Номер записи: 26
10-02-2010 дата публикации

New application of exenatide acetate and medicine aiming at new application

Номер: CN0101642561A
Автор: XU JUAN, QIAO DESHUI, ZHOU YING, YANG JIE, CAI AIJUN, GAO XUEQIN, JUAN XU, DESHUI QIAO, YING ZHOU, JIE YANG, AIJUN CAI, XUEQIN GAO
Принадлежит:

The invention relates to the field of pharmaceutical chemistry, in particular to a new application of exenatide acetate and medicine aiming at the new application. The new application of exenatide acetate is that the exenatide acetate is taken as a medicine used for preventing and curing diabetes and coronary disease. The invention also provides a medicine aiming at the new application. The medicine contains active constituent (exenatide acetate) of 0.005-0.4g/100ml and appropriate amount of isotonic agent. The invention has the advantages that the exenatide acetate has better curative effecton patients suffering from diseases of diabetes and coronary disease than on patients suffering from one or none of the two diseases of diabetes and coronary disease. The exenatide acetate not only relieves the symptom of diabetes of patients, but also ameliorates the function of nervi vascularis, thus facilitating the complete recovery of patients.

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Номер записи: 27
20-05-2009 дата публикации

Chinese medicine prepared aconite root and method for establishing fingerprint of alkaloid in extract thereof

Номер: CN0101433604A
Автор: YANG CHUNYAN, LIN BIN, LIU YUEYUE, WANG CHENG, QIAO DESHUI, GAO XUEQIN, CHUNYAN YANG, BIN LIN, YUEYUE LIU, CHENG WANG, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to a method for establishing fingerprint of alkaloid in traditional Chinese medicine aconite or extract thereof. The method adopts an opposite phase high performance liquid chromatography, uses octadecylsilane chemically bonded silica or octadsilane chemically bonded silica as a filling agent, and uses an organic phase-buffer solution as a mobile phase, wherein pH value of the organic phase-buffer solution is 3.0 to 8.0, detection wavelength is 230 to 240 nanometers, the organic phase accounts for 20 to 70 percent of volume percentage of the mobile phase, and the organic phase is acetonitrile or methanol; the buffer solution is one of ammonium acetate-acetic acid buffer solution, triethylamine-acetic acid buffer solution, triethylamine-ammonium acetate-acetic acid buffer solution and triethylamine-acetic acid ammonium-acetic acid buffer solution; and the method comprises the following steps: using proper amount of aconitine, mesaconine or hypaconitine to prepare reference ...

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Номер записи: 28
16-07-2008 дата публикации

Hydrochloric acid glitazone dispersion piece and its preparation method

Номер: CN0101219122A
Автор: SHEN ZHOU, TIAN HAIYING, QIAO DESHUI, GAO XUEQIN, ZHOU SHEN, HAIYING TIAN, DESHUI QIAO, XUEQIN GAO
Принадлежит:

The invention relates to a pioglitazone hydrochloride tablet and a preparation method thereof. The pioglitazone hydrochloride tablet comprises a pioglitazone, a diluting agent, a disintegrating agent, a bonding agent, a lubricant and other auxiliary agents, wherein, the diluting agent includes one or more components selected from lactose, amylum pregelatinisatum and microcrystalline cellulose; the disintegrating agent includes one component selected from cross-linked polyvinyl pyrrolidone and microcrystalline cellulose or the combination thereof; the bonding agent comprises amylum pregelatinisatum and water or ethanol liquor of hydroxypropyl methyl cellulose; the lubricant comprises magnesium stearate. The preparation method comprises that (in sequence): the pioglitazone hydrochloride and the auxiliary materials thereof are weighed and screened according to a prescription; the diluting agent, other auxiliary agents and part of the disintegrating agent are mixed to obtain a powder mixture ...

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Номер записи: 29