27-04-2011 дата публикации
Номер: CN0102030670A
Принадлежит:
The invention relates to a method for synthesizing DP-b99, which comprises the following steps of: adding o-nitrophonol A and potassium carbonate into a solvent, dissolving, and adding 1, 2-dibromoethane to obtain B; dissolving B into a solvent, adding into an autoclave, heating to react to obtain C under the environment of palladium, carbon and hydrogen; mixing C with diisopropylamine, sodium iodide and ethyl bromoacetate in acetonitrile, and refluxing to react at 80 to 90 DEG C to obtain D; adding D into ethanol, dropwise adding the water solution of potassium hydroxide, reacting at room temperature, controlling pH value at 2-4, and eluting E; adding E into acetic anhydride containing pyridine, heating to completely react, adding diethyl ether, and precipitating to obtain F; adding sodium into ethylene glycol at room temperature, dropwise adding 1-bromooctane, heating to completely react, adding water, and extracting by using diethyl ether to obtain I; and mixing F with I, heating to ...
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