Dynamic bioactive nanofiber scaffolding

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

Bone graft material

The present disclosure relates to a bone graft material and a bone graft implant formed from the material. In some embodiments, the bone graft implant comprises a porous matrix having a plurality of overlapping and interlocking bioactive glass fibers and a plurality of pores dispersed throughout the matrix, whereby the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the pores are characterized by pore diameters ranging from about 100 nanometers to about 1 millimeter. The implant may be formed into a desired shape for a clinical application. The embodiments may be employed to treat a bone defect. For example, the bone graft material may be wetted and molded into a suitable form for implantation. The implant may then be introduced into a prepared anatomical site.

Dynamic bioactive nanofiber scaffolding

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance. 121-. (canceled)22. A biologically resorbable tissue regrowth scaffold material , comprising:a porous, pliable and formable support matrix comprising a plurality of overlapping and entangled solid, polymer-free bioactive, resorbable ceramic fibers;a plurality of pores distributed throughout the support matrix; anda plurality of bioactive, resorbable beads distributed throughout the support matrix;wherein each respective fiber has a diameter from about 5 nanometers to about 100 micrometers.23. The biologically resorbable tissue regrowth scaffold material of claim 22 , wherein the fibers are composed of a material selected from the group including calcium phosphate claim 22 , hydroxyapatite claim 22 , bioactive glass and combinations thereof.24. The biologically resorbable tissue regrowth scaffold material of claim 22 , wherein the beads are solid and wherein the beads have the same composition as the fibers.25. The biologically resorbable tissue regrowth scaffold material of claim 22 , wherein the beads are hollow defining respective inner volumes; and wherein each respective inner volume is filled with a filling selected from the group comprising medicines claim 22 , nutritive supplements claim 22 , antibiotics claim 22 , antivirals claim 22 , vitamins and combinations thereof.26. The biologically resorbable tissue regrowth scaffold material of claim 22 , wherein at least some of the respective beads are fused to ...

DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance. 1. A resorbable bone graft scaffold material , comprising:a plurality of overlapping and interlinking nonporous, polymer-free bioactive ceramic fibers defining a scaffold structure;a plurality of pores distributed throughout and defined by the scaffold; anda plurality of bioactive, resorbable spheres distributed in at least some of the respective pores;wherein each respective sphere is fused to at least one ceramic fiber;wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers;wherein the fibers are a bioactive, resorbable material.2. The resorbable bone graft scaffold material of wherein the fibers are composed of a material selected from the group including calcium phosphate claim 1 , hydroxyapatite claim 1 , bioactive glass and combinations thereof.3. The resorbable bone graft scaffold material of wherein the fibers are substantially composed of 45S5 bioactive glass.4. The resorbable bone graft scaffold material of wherein the spheres are solid and wherein the spheres have the same composition as the fibers.5. The resorbable bone graft scaffold material of wherein the spheres are hollow defining respective inner core volumes; and wherein each respective inner core volume is filled with a filling selected from the group including medicines claim 1 , nutritive supplements claim 1 , antibiotics claim 1 , antivirals claim 1 , vitamins and combinations thereof ...

DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance. 1. A resorbable bone graft scaffold material , comprising:a plurality of overlapping and interlinking nonporous, polymer-free bioactive ceramic fibers defining a scaffold structure;a plurality of pores distributed throughout and defined by the scaffold; anda plurality of bioactive, resorbable spheres distributed in at least some of the respective pores;wherein each respective sphere is fused to at least one ceramic fiber;wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers;wherein the fibers are a bioactive, resorbable material.2. The resorbable bone graft scaffold material of wherein the fibers are composed of a material selected from the group including calcium phosphate claim 1 , hydroxyapatite claim 1 , bioactive glass and combinations thereof.3. The resorbable bone graft scaffold material of wherein the fibers are substantially composed of 45S5 bioactive glass.4. The resorbable bone graft scaffold material of wherein the spheres are solid and wherein the spheres have the same composition as the fibers.5. The resorbable bone graft scaffold material of wherein the spheres are hollow defining respective inner core volumes; and wherein each respective inner core volume is filled with a filling selected from the group including medicines claim 1 , nutritive supplements claim 1 , antibiotics claim 1 , antivirals claim 1 , vitamins and combinations thereof ...

DYNAMIC BIOACTIVE BONE GRAFT MATERIAL HAVING AN ENGINEERED POROSITY

The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient. 1. A method of treating a bone defect , comprising:providing a bone graft material, the material comprising:a porous matrix comprising a plurality of overlapping and interlocking bioactive glass fibers and bioactive glass particulates distributed throughout the fibers, the fibers and particulates each having varying diameters, and a range of pores defined by the spaces between said fibers and particulates, the varying diameters of the fibers and particulates controlling pore size and distribution of the range of pores and overall porosity of the matrix, the matrix further having a distributed porosity based on said range of pores such that the matrix is configured for staged resorption, the range of pores comprising micropores and macropores;forming an implant from the bone graft material, the implant being formed by shaping the material into a shape and size for insertion into the bone defect; andimplanting the formed implant into the bone defect.2. The method of claim 1 , wherein the range of pores further comprises nanopores or mesopores.3. The method of ...

Dynamic bioactive nanofiber scaffolding

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance. 121-. (canceled)22. A resorbable tissue graft scaffold material , consisting essentially of:a plurality of overlapping and interlinking polymer-free, bioactive ceramic fibers defining a three-dimensional, flexible, porous scaffold; anda plurality of bioactive, resorbable glass or ceramic beads distributed throughout the porous scaffold;wherein the beads contribute from 60 weight percent to 95 weight percent of the tissue graft scaffold material and wherein the tissue graft scaffold is polymer-free.23. The tissue graft scaffold material of claim 22 , wherein the fibers are composed of a material selected from the group consisting of calcium phosphate claim 22 , hydroxyapatite claim 22 , bioactive glass and combinations thereof.24. The tissue graft scaffold material of claim 22 , wherein the beads are composed of the same material as the fibers.25. The tissue graft scaffold material of claim 22 , wherein the beads are solid.26. The tissue graft scaffold material of claim 22 , wherein the beads are generally spherical.27. The tissue graft scaffold material of claim 22 , wherein the beads are hollow to define respective inner core volumes claim 22 , the inner core volumes being filled with medicines claim 22 , nutritive supplements claim 22 , antibiotics claim 22 , antivirals claim 22 , vitamins or combinations thereof.28. The tissue graft scaffold material of claim 22 , wherein the beads are porous.29. The tissue ...

WOUND CARE DEVICE HAVING DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance. 121-. (canceled)22. A wound care device , comprising:a porous, pliable and formable support matrix comprising a plurality of overlapping and entangled solid, polymer-free bioactive, resorbable ceramic fibers, each respective fiber having a diameter ranging from about 5 nanometers to about 100 micrometers;a plurality of pores distributed throughout the support matrix; anda plurality of bioactive, resorbable glass or ceramic beads distributed throughout the support matrix;wherein the wound care device is configured to be sufficiently chemically durable to reduce or stop blood loss from the wound.23. The wound care device of claim 22 , wherein the beads contribute about 60 weight percent and the fibers contribute about 40 weight percent of the support matrix claim 22 , further wherein the support matrix has a bulk density of greater than about 0.1 g/cc for blood treatment applications.24. The wound care device of claim 22 , wherein the beads contribute about 90 weight percent and the fibers contribute about 10 weight percent of the support matrix claim 22 ,further wherein the support matrix has a bulk density of greater than about 0.5 g/cc for blood treatment applications.25. The wound care device of claim 22 , wherein the fibers are composed of a material selected from the group including calcium phosphate claim 22 , hydroxyapatite claim 22 , bioactive glass and combinations thereof.26. The wound care device of ...

Dynamic bioactive bone graft material and methods for handling

Un kit para preparar un implante de injerto óseo bioactivo dinámico, que comprende: una matriz fibrosa y porosa de fibras de vidrio bioactivo, en la que las fibras se caracterizan por diámetros de fibra que varían entre aproximadamente 5 nanómetros y aproximadamente 100 micrómetros, y en la que la porosidad de la matriz varía entre aproximadamente 100 nanómetros y aproximadamente 1 milímetro; y q una bandeja de molde que incluye un componente de base y un componente de tapa configurado para encajar dentro del componente de base, teniendo cada uno de los componentes de base y de tapa partes rebajadas o elevadas correspondientes para formar una forma moldeada predefinida. A kit for preparing a dynamic bioactive bone graft implant, comprising: a fibrous and porous matrix of bioactive glass fibers, in which the fibers are characterized by fiber diameters ranging between about 5 nanometers and about 100 micrometers, and in the one that the porosity of the matrix varies between approximately 100 nanometers and approximately 1 millimeter; and q a mold tray that includes a base component and a lid component configured to fit within the base component, each of the base and lid components having corresponding lowered or raised portions to form a predefined molded shape.

Dynamic bioactive bone graft material having an engineered porosity

Silane coating process for high alkali bioactive glasses

A method of preparing a ceramic-resin composite material for bone repair, including preparing a predetermined amount of pH controlled substantially anhydrous coupling agent by mixing a liquid silane material, alcohol and organic acid, producing particulate bioactive glass having a desired particle size of less than about 53 mesh, measuring a desired quantity of the particulate bioactive glass into a mixing vessel, heating the mixing vessel and particulate bioactive glass to about 100 degrees Celsius, mixing the heated quantity of particulate bioactive glass and spraying a predetermined amount of substantially anhydrous coupling agent into the heated quantity of particulate bioactive glass to define an admixture, mixing the admixture for sufficient time to define a quantity of substantially evenly coated particles, heating the quantity of substantially evenly coated particles for sufficient time to evolve excess solvent therefrom, and incorporating the quantity of substantially evenly coated particles into a resinous matrix to define a bone replacement medium.

Dynamic bioactive nanofiber scaffolding

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

Dynamic bioactive bone graft material having an engineered porosity

The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient.