Genes and proteins, and their uses.

According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines to immunise a patient against microbial infection.

Immunoassay for detecting group B streptococcus.

Immunoadsorbent combinations for the detection and diagnosis of group b streptococcus polysaccharide antigen, comprising an insoluble carrier, a capture agent having an affinity for specifically binding to the trirhamnose epitope of group b streptococcus antigen and having the formula @-l-rhap(1->2)-@-l-rhap(1->2)@-rhap-1- wherein rhap is rhamnose, and an natigen marker agent having an affinity for binding to monorhamnose epitope of group b streptococcus polysaccharide is bound to the carrier. An immunoassay method test kit and polyclonal antibody are also described.

Outer surface proteins, their genes, and their use.

According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be located on the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines for the immunisation of a patient against microbial infection.

Attenuated Gram Negative Bacteria

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed. 136-. (canceled)37. A mutant of a gram negative bacterium belonging to the family Pasteurellaceae having a mutation in a nucleotide sequence , wherein the nucleotide sequence prior to mutation consists essentially of SEQ ID NO. 40 and encodes a polypeptide , and wherein the mutation attenuates virulence of the bacterium.38Pasteurella, ActinobacillusHaemophilus.. The mutant of claim 37 , wherein the gram negative bacterium belongs to the genera claim 37 , or39Pasteurella multocida, Pasteurella multocidaPasteurella multocidaPasteurella haemolytica, Pasteurella anatipestiferActinobacillus. The mutant of claim 39 , wherein the gram negative bacterium is: P-1059 claim 39 , PM70 claim 39 , or pleuropneumoniae.40Pasteurella multocida.. The mutant of claim 39 , wherein the gram negative bacterium is41. The mutant of claim 37 , wherein the mutation is obtained by transposon insertion into the nucleotide sequence claim 37 , directed mutagenesis of the nucleotide sequence claim 37 , or homologous recombination.42. The mutant of claim 41 , wherein the mutation obtained by directed mutagenesis or homologous recombination is a result of a deletion claim 41 , insertion claim 41 , or substitution of at least one nucleotide of the nucleotide sequence.43Pasteurella multocida. The mutant of claim 42 , wherein ...

SYSTEMS AND METHODS FOR CONVERSION ANALYTICS

Tools are provided for collecting and distributing information from guidance counselors, parents, students, schools, and other third parties regarding the college search and application process. Data points are collected through interaction with computer applications and used to match schools and applicants, provide personalized tours, and predict conversion probabilities allowing colleges and students to tailor their application and admissions processes more narrowly than previously possible. 1. A computer implemented method of targeting potential applicants , the method comprising:receiving, at a computer comprising a processor coupled to a tangible, non-transient memory, a plurality of data points from a user for a college obtained by monitoring user interaction with the computer, the plurality of data points comprising two or more selected from the group consisting of: a college search result. an opened message, a clicked on message, an interactive program begun, an interactive program completed, a registration for event, an application submission, college profile views, a college profile interaction, a college profile added to favorites, college search filters, a user profile, and communication subscriptions;assigning a weight to the plurality of data points;{'sup': '.', 'determining a compatibility score for the user and the college using the weighted plurality of data pointsand'}calculating a probability of conversion based on the compatibility score, wherein the probability of conversion comprises one selected from the group consisting of a probability of the user requesting more information, registering for an admissions event, attending an admissions event, applying to the school, a probability of the user placing a deposit with the school, and a probability of the user enrolling in classes at the school.2. The method of further comprising providing the compatibility score in a report to the college wherein the compatibility score is greater than a ...

SUPRACHORIODAL DRAINAGE TUBE IN A FLOW CONTROL SYSTEM

Described herein is a treatment device for the drainage of fluid within an eye of a patient. The treatment device comprises a drainage tube and a flow system in fluid communication with the drainage tube. The drainage tube has a lumen and comprises an inlet tube portion and an outlet tube portion, and is configured to convey aqueous humor through the lumen from an anterior chamber of the eye to a suprachoroidal space of the eye. The inlet tube portion extends from the anterior chamber to the flow system, and the outlet tube portion is flexible to conform to the curvature of the suprachoroidal space and extends from the valve system to the suprachoroidal space. The flow system is configured to control intraocular pressure by throttling flow rates of the aqueous humor through the drainage tube. 1. A treatment device for the drainage of fluid within an eye of a patient , comprising:a drainage tube having a lumen and comprising an inlet tube portion and an outlet tube portion, the drainage tube configured to convey aqueous humor through the lumen from an anterior chamber of the eye to a suprachoroidal space of the eye; anda flow system in fluid communication with the drainage tube, the flow system configured to control intraocular pressure by throttling flow rates of the aqueous humor through the drainage tube,wherein the inlet tube portion is arranged to extend from the anterior chamber to the flow system, and the outlet tube portion is flexible to conform to the curvature of the suprachoroidal space and is arranged to extend from the valve system to the suprachoroidal space.2. The treatment device of claim 1 , wherein the flow system is arranged to be positioned within the subconjunctival space.3. The treatment device of claim 1 , wherein the outlet tube portion includes a proximal end coupled to the flow system and a distal end arranged to be positioned within the suprachoroidal space claim 1 , and an outlet tube lumen extending from the proximal end to the distal ...

METHODS FOR CANCER DETECTION

The present disclosure provides methods for cancer detection. The methods can comprise non-invasive detection of a biomarker from a subject. The methods can be used in combination with additional screening methods for greater accuracy of detection. 1. A method for determining a health state of a subject , the method comprising:a) providing a saliva sample from a subject;b) quantifying a sample level of a biomarker from the saliva sample, wherein the biomarker is from an exosome in the saliva sample;c) comparing the sample level of the biomarker to a reference level of the biomarker, wherein the reference level is obtained from a subject having breast cancer; andd) determining a risk score of the subject for breast cancer based on the comparing.2. The method of claim 1 , further comprising imaging a breast tissue of the subject.3. The method of claim 2 , wherein the imaging is performed using a mammogram.4. The method of claim 1 , further comprising adjusting the risk score of the subject based on the results from the mammogram.5. The method of claim 1 , further comprising lysing the exosome to release the biomarker prior to step b).6. The method of claim 4 , further comprising enriching an exosome fraction of the saliva sample prior to the lysing.7. The method of claim 1 , further comprising stabilizing the exosome fraction following the enriching.8. The method of claim 1 , wherein the biomarker is a cell-free nucleic acid.9. The method of claim 8 , wherein the cell-free nucleic acid is RNA.10. The method of claim 9 , wherein the RNA is mRNA or miRNA.11. The method of claim 10 , wherein the mRNA is a transcript of a gene selected from the group consisting of LCE2B claim 10 , HIST1H4K claim 10 , ABCA1 claim 10 , ABCA2 claim 10 , TNFRSF10A claim 10 , AK092120 claim 10 , DTYMK claim 10 , ALKBH1 claim 10 , MCART1 claim 10 , Hs.161434 claim 10 , and any combination thereof.12. The method of claim 9 , wherein the quantifying further comprises reverse transcribing the RNA. ...

MULTI-COMPARTMENT WATER-SOLUBLE CAPSULES

A three-compartment water-soluble capsule, each compartment containing a part of a liquid detergent composition, the compartments being arranged side-by-side to provide a central compartment flanked on respective sides by a first and a second side compartment, the capsule being formed from two sheets of water-soluble film, the two sheets of film being sealed together to form a sealing web around each compartment, the sealing web lying in a sealing plane, each of the three compartments extending at a maximum the same distance above and below the sealing plane, wherein the sealing web comprises an annular sealing web defining the periphery of the capsule, and two internal sealing webs which each extend across the capsule, each internal sealing web serving to connect the central compartment with an adjacent side compartment and to separate their contents, wherein each internal sealing web has a continuously curved shape. 1. A three-compartment water-soluble capsule , each compartment containing a part of a liquid detergent composition , the three compartments being arranged side-by-side to provide a central compartment flanked on respective sides by a first side compartment and a second side compartment , the capsule being formed from two sheets of water-soluble film , the two sheets of film being sealed together to form a sealing web around each compartment , the sealing web lying in a sealing plane , each of the three compartments extending at a maximum the same distance above and below the sealing plane , wherein the sealing web comprises a generally annular sealing web defining the periphery of the capsule , and two internal sealing webs which each extend across the capsule a machine direction , each internal sealing web serving to connect the central compartment with an adjacent side compartment and to separate the contents of the central and adjacent side compartments , wherein each internal sealing web has a continuously curved shape.2. A three-compartment water ...

Portable device and associated software to enable voice-controlled navigation of a digital audio player

Methods are disclosed to describe a portable device that enables the user to navigate the menus of a digital audio player using a set of simple voice commands. The system is comprised of a microcontroller, serial flash memory device, on-board microphone, volume controller, a connector for headphones or external audio amplifier and a connector for an external microphone. Power is supplied by the digital audio device via a connector. The device is loaded with necessary software to interface with the digital audio player using Transistor-Transistor-Logic-level serial commands. The loaded software allows for a search for playlists, artists, albums, genres, or songs, which is accomplished via an extremely low memory ASCII character comparison with sublinear performance functionality.

Subcarrier multiple access passive optical network

Adjacent channel interference at an optical receiver of an optical network is significantly reduced using electrical bandwidth limiting means at optical transmitters of the network which narrow the bandwidth of the modulated subcarrier signal transmitted from the optical transmitters. An optical transmitter is responsive to an input data signal to generate a modulated subcarrier signal having a power density spectrum which includes substantially all of the main lobe and significantly attenuated side lobes of the modulated carrier signal. The modulated subcarrier signal is then used to modulate an optical source signal transmitted from the optical transmitter.

Power coupling for a chain saw

A power transmission device adapted to be employed with a chain saw for providing a rotary output in a plurality of directions. The device includes a housing having an input shaft coupled with an output shaft where the input and output shafts are right angles to one another. The housing serves as the support for the driven mechanism and provides mounting flanges about both the input and output shafts. The mounting flange associated with the input shaft cooperates with a chain guideplate to adjustably mount the housing to the chain saw. By simply loosening two screws, the orientation of the output shaft relative to the chain saw can be changed by up to substantially 180 degrees. The mounting flange around the output shaft is designed to allow a 360-degree range in orientation of the driven device about an axis coincident with the axis of the output shaft.

Attenuated microorganisms for the treatment of infection

The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.

Method and system for implementing programmable texture lookups from texture coordinate sets

A method and system for implementing programmable texture lookups from texture coordinate sets. The method includes the step of generating a plurality of texture coordinates using a shader module. The shader module executes floating point calculations on received pixel data to generate the texture coordinates. A plurality of texture values are fetched using the texture coordinates. The fetching is performed by a texture unit coupled to receive the texture coordinates from the shader module. The fetching of the texture values is programmable with respect to the texture coordinates such that the number of texture coordinates are decoupled from the number of textures.

Photodiode

Abstract of the Disclosure In this invention, there is disclosed a new photodiode which comprises a semimetal/semiconductor junction. Distortion of the bands associated with this type of junction result in current flow when an electron hole pair is formed by, for example, a photon impinging upon the junction. The photodiode operates in the photovoltaic mode. However, rather than relying on impurity doping to fabricate a p-n junction, the semimetallic nature of HgTe and its large conduction band offsets with Hg1-xCdx Te are used to create a rectifying Schottky like structure.

Coordination of control operations in an optical network

In one embodiment, a control method, according to which a cascade of control messages is propagated between nodes of an optically transparent network, with each message being sent from a node to an adjacent downstream node to inform the latter about a control operation scheduled to be performed at the message-sending node and/or an upstream node that impacts an optical communication signal received at that downstream node. The cascade of control messages effectively creates an ad hoc control domain, in which control operations performed at various nodes of that domain can be coordinated to reduce unfavorable interactions between those control operations. By repeatedly propagating appropriate cascades of control messages through the network, control domains can be changed dynamically and adaptively to reflect any changes to the network topology, equipment, and/or traffic distribution.

Method and apparatus for loop and branch instructions in a programmable graphics pipeline

A method and apparatus for executing loop and branch program instructions in a programmable graphics shader. The programmable graphics shader converts a sequence of instructions comprising a portion of a shader program and selects a first set of fragments to be processed. Subsequent sequences of instructions are converted until all of the instructions comprising the shader program have been executed on the first set of fragments. Each remaining set of fragments is processed by the shader program until all of the fragments are processed in the same manner. Furthermore, the instructions can contain one or more loop or branch program instructions that are conditionally executed. Additionally, when instructions within a loop as defined by a loop instruction are being executed a current loop count is pipelined through the programmable graphics shader and used as an index to access graphics memory.

System, method and computer program product for a programmable pixel processing model with instruction set

A system, method and computer program product are provided for programmable pixel processing in a computer graphics pipeline (400). Initially, pixel data is received from a source buffer (402). Thereafter, programmable operations (404) are performed on the pixel data in order to generate output. The operations are programmable (404) in that a user may utilize instructions from a predetermined instruction set for generating the same. Such output is stored in a register (406).

Multi-compartment water-soluble capsules

A three-compartment water-soluble capsule, each compartment containing a part of a liquid detergent composition, the compartments being arranged side-by-side to provide a central compartment flanked on respective sides by a first and a second side compartment, the capsule being formed from two sheets of water-soluble film, the two sheets of film being sealed together to form a sealing web around each compartment, the sealing web lying in a sealing plane, each of the three compartments extending at a maximum the same distance above and below the sealing plane, wherein the sealing web comprises an annular sealing web defining the periphery of the capsule, and two internal sealing webs which each extend across the capsule, each internal sealing web serving to connect the central compartment with an adjacent side compartment and to separate their contents, wherein each internal sealing web has a continuously curved shape.

Photodiode

In this invention, there is disclosed a new photodiode which comprises a semimetal/semiconductor junction. Distortion of the bands associated with this type of junction result in current flow when an electron hole pair is formed by, for example, a photon impinging upon the junction. The photodiode operates in the photovoltaic mode. However, rather than relying on impurity doping to fabricate a p-n junction, the semimetallic nature of HgTe and its large conduction band offsets with Hg 1-x Cd x Te are used to create a rectifying Schottky like structure.

Inflator with drop-in batteries and universal adapters

A portable, battery powered inflator with removable batteries which are switch activated. The inflator has an air intake and output for delivering air into a variety of air bladders with different sized valves. The batteries are typical dry cells and not rechargeable to save cost. The inflator has a cover that allows quick removable and replacement of the batteries. An adapter assembly including a transition structure and adapters are provided to allow inflation of a variety of bladders having different sized valves. The attaching of the transition structure engages the switch completing an electrical circuit that activates the motor to deliver air automatically.

Method and apparatus for multithreaded processing of data in a programmable graphics processor

A graphics processor and method for executing a graphics program as a plurality of threads where each sample to be processed by the program is assigned to a thread. Although threads share processing resources within the programmable graphics processor, the execution of each thread can proceed independent of any other threads. For example, instructions in a second thread are scheduled for execution while execution of instructions in a first thread are stalled waiting for source data. Consequently, a first received sample (assigned to the first thread) may be processed after a second received sample (assigned to the second thread). A benefit of independently executing each thread is improved performance because a stalled thread does not prevent the execution of other threads.

Outer surface proteins, their genes, and their use

According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be located on the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines for the immunisation of a patient against microbial infection.

System, method and computer program product for programmable shading using pixel shaders

A system, method and computer program product are provided for performing shader calculations in a graphics pipeline. Initially, a shading calculation is performed in order to generate output. Thereafter, an additional shading calculation is carried out. Such additional shading calculation includes converting the output of the shading calculation into a floating point format. Further, a dot product is calculated utilizing the converted output and texture coordinates. The dot product is then clamped. Next, the clamped dot product is stored in a plurality of color components.

Outer surface proteins, their genes, and their use

According to the present invention, a series of genes are identified in Group B Streptococcus , the products of which may be located on the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines for the immunisation of a patient against microbial infection.

Process for refining a viscous feedstock by cracking

High severity visbreaking

HIGH SEVERITY VISBREAKING ABSTRACT OF THE DISCLOSURE The severity of a visbreaking operation is increased by treating product to remove a heavier phase in an amount of less than 15 weight percent and provide a remaining product having a Shell Hot Filtration number of less than 0.25.

Method and apparatus for modifying depth values using pixel programs

A method and apparatus for generating depth values in a programmable graphics system. Depth values are calculated under control of a pixel program using a variety of sources as inputs to programmable computation units (PCUs) in the programmable graphics systems. The PCUs are used to compute traditional interpolated depth values and modified depth values. Th PCUs are also used to compute arbitrary depth values which, unlike traditional interpolated depth values and modified depth values, are not dependent on the coordinates of the geometry primitive with which the arbitrary depth values are associated. Several sources are available as inputs to the PCUs. Clipping with optional clamping is performed using either interpolated depth values or calculated depth values, where calculated depth values are arbitrary depth values or modified depth values. Final depth values, used for depth testing, are selected from interpolated depth values and arbitrary depth values after clipping is performed.

Outer surface proteins, their genes, and their use

According to the present invention, a series of genes are identified in Group B Streptococcus , the products of which may be located on the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines for the immunization of a patient against microbial infection.

Improved subcarrier multiple access passive optical network

Adjacent channel interference at an optical receiver of an optical network is significantly reduced using electrical bandwidth limiting means at optical transmitters of the network which narrow the bandwidth of the modulated subcarrier signal transmitted from the optical transmitters. An optical transmitter is responsive to an input data signal to generate (57) a modulated subcarrier signal having a power density spectrum which includes substantially all of the main lobe and significantly attenuated side lobes of the modulated carrier signal. The modulated subcarrier signal is then used to modulate (57, 55) an optical source signal transmitted from the optical transmitter.

Attenuated gram negative bacteria

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed.

Virulence genes and proteins, and their use

The present invention is based on the identification of a series of virulence genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organisms. The identification of the genes allows them, or their expressed products, to be used in a number of ways to treat infection.

Attenuated gram negative bacteria

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed.

GRAM NEGATIVE BACTERIA ATENUATED.

Mutante de una bacteria gram negativa, en el que dicha bacteria presenta una mutación en una secuencia de nucleótidos que codifica un polipéptido que tiene una identidad que es igual o superior al 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, ó 99% con una secuencia de aminoácidos codificada por la secuencia de nucleótidos SEC ID No: 75, dando lugar dicha mutación a una virulencia atenuada de la bacteria, en el que la mutación es una inserción entre los nucleótidos 1072-1087 en la SEC ID No: 75. A mutant of a gram negative bacterium, in which said bacterium has a mutation in a nucleotide sequence that encodes a polypeptide having an identity that is equal to or greater than 70%, 75%, 80%, 85%, 90%, 95 %, 96%, 97%, 98%, or 99% with an amino acid sequence encoded by the nucleotide sequence SEQ ID No: 75, said mutation giving rise to an attenuated virulence of the bacterium, in which the mutation is a insertion between nucleotides 1072-1087 in SEQ ID NO: 75.

Virulence genes and proteins, and their use

The present invention is based on the identification of a series of virulenc e genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organism. The identificaiton of the genes allows them, or their expressed products, to be used in a number of ways to treat infection.

External surface proteins, genes and use thereof

System and method for processing divergent samples in a programmable graphics processing unit

A method for processing divergent samples in a programmable graphics processing unit is described. In one embodiment, the method includes the step of incrementing a subroutine depth of a first sample to designate that first call instructions are to be executed on the first sample. The method also includes the steps of pushing state data of a second sample upon which the first call instructions are not to be executed onto a global stack and executing the first call instructions on the first sample.

Group b streptococcus proteins, and their use

According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines to immunise a patient against microbial infection.

Attenuated gram negative bacteria

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96% , 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO:2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed.

Apparatus and method for programmable optical interconnections

A programmable optical interconnection apparatus (10) and method in which a plurality of spatial light modulators (14) form a plurality of spatially modulated beams (22a-b) from a data signal (12). A hologram (16) is responsive to the spatially modulated beams (22a-b) for generating at least two destructively interfering coherent beams (36a-b) at a first optical detector (18a) to thereby disconnect the data signal (12) therefrom, and for simultaneously generating at least two constructively interfering coherent beams (38a-b) at a second optical detector (18b) to thereby connect the data signal (12) thereto. The hologram (16) is preferably a computer generated thin hologram (16) which does not rely on Bragg diffraction. A low cost, high density, high efficiency programmable optical interconnect is thereby provided.

Treatment of feed for high severity visbreaking

ABSTRACT OF THE DISCLOSURE Prior to upgrading a viscous feed by visbreaking, at least a portion of the feed is treated to remove a heavy phase in specified amounts, whereby the severity of the visbreaking may be increased. The Shell Hot Filtration number of the visbreaking product is reduced by at least 75%, compared to visbreaking of untreated feed at the same severity.

Genes and proteins, and their use

According to the present invention, a series of genes are identified in Group B Streptococcus , the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines to immunize a patient against microbial infection.

Attenuated microorganisms for the treatment of infection

The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.

Streptococcus pyogenes virulence genes and proteins and their use

A találmány tárgyát virulencia gének, proteinek és ezek alkalmazásaképezi. Közelebbről: a találmány tárgyát a Streptococcus pyogenes-bőlkapott gének és fehérjék/peptidek képezik, valamint ezek alkalmazása aterápiában és gyógyhatású anyagok szkrínelésében. A találmány azon afelismerésen alapul, hogy a S. pyogenesben virulencia gének vannakjelen. A találmány egyik tárgyát egy operon által kódolt peptidterápiás vagy diagnosztikus alkalmazása képezi, amely a S. pyogenesvagy egy Gram pozitív baktériumban jelen levő homológja vagyfunkcionális fragmentuma valamelyik nukleotid szekvenciáját /SEQ IDNo. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35,37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59 és 61/ tartalmazza. Apeptidek többféle terápiás alkalmazási lehetőséget képviselnek Acsoportbeli Streptococcus fertőzések esetében, ideértve aprofilaktikus alkalmazást is vakcina alakjában. A peptidet kódolópolinukleotid szekvencia, a peptid kifejezésére transzformáltgazdaszervezet, valamint a gyengített mikroorganizmus, amely anukleotid szekvenciák valamelyikének kifejeződését károsító mutációnment át, ugyancsak a találmány tárgyát képezi. Ó The present invention relates to virulence genes, proteins and their uses. More particularly, the present invention relates to genes and proteins / peptides derived from Streptococcus pyogenes and their use in therapy and screening of therapeutic agents. The invention is based on the recognition that virulence genes are present in S. pyogenes. One object of the present invention is the therapeutic or diagnostic use of an operon encoded peptide which is a nucleotide sequence of a S. pyogenes or a homologue or functional fragment of a Gram positive bacterium / SEQ ID NO. 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35.37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59 and 61 /. Apeptides represent a variety of therapeutic applications for Group A Streptococcus infections, including aprophylactic administration in ...

Attentuated gram negative bacteria

Genes and proteins, and their use

A tal lm ny t rgya külső felszíni fehérjék és génjeik azonosít sa ésezek alkalmaz sa. Pontosabban a tal lm ny B csoportú Streptococcusbólkinyerhető, phol-l3-ként, pho3-21-ként, pho2-15-ként, pho3-18-ként:,pho3-22-ként, pho3-3-ként, pho3-17-ként, pho2-2-ként, phol-'iként,pho3-l-ként, pho3-23-ként, pho3-50-ként, phol-14-ként, pho2-10-ként,pho3-14-ként, pho3-24-ként és pho3-29- ként azonosított gének ltalkódolt peptidekre, a peptideket kódoló polinukleotidokra, transzformlt gazdasejtekre és a peptideket tartalmazó vakcin kra vonatkozik.Ezek a peptidek potenci lis gyógyszerek és virulencia szűrésére isfelhaszn lhatóak. Ó The outer surface proteins and their genes are identified and used by the public. Specifically, it can be obtained from Streptococcus group B, as phol-13, pho3-21, pho2-15, pho-18-18, pho3-22, pho3-3, pho3-17- sulfur, pho2-2, phol ', pho3-1, pho3-23, pho3-50, phol-14, pho2-10, pho3-14, pho3 Genes identified as -24 and pho3-29 relate to coded peptides, polynucleotides encoding peptides, transformed host cells, and vaccines containing peptides. These peptides can also be used to filter potential drugs and virulence. HE

Attentuated gram negative bacteria

Wavelength-selective add/drop arrangement for optical communication systems

A WDM input signal received at an add/drop node is coupled onto both a "drop" transmission path and a "through" transmission path within the node. Optical channels to be dropped are then processed within the "drop" path, such as by optical demultiplexing. Because a copy of the same WBM input signal is routed on the "through" path, a dynamically configurable and programmable wavelength blocker selectively blocks the optical channels that are being dropped from the WDM input signal and passes through those optical channels not being dropped onto the "through" path. In an "add" path within the node, optical channels are selectively added, such as by using optical multiplexing. Those optical channels from the multiplexed optical signal that are not designated for "add" (e.g., "unused" channels) are selectively blocked within the "add" transmission path. Optical channels from the "add" and "through" paths are then combined form a WDM output signal.

Viral genes, proteins and their use

Attenuated gram negative bacteria

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identified SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such a mutant are also disclosed and claimed.

Wavelength-selective add/drop arrangement for optical communication systems

A WDM input signal received at an add/drop node is coupled onto both a "drop" transmission path and a "through" transmission path within the node. Optical channels to be dropped are then processed within the "drop" path, such as by optical demultiplexing. Because a copy of the same WDM input signal is routed on the "through" path, a dynamically configurable and programmable wavelength blocker selectively blocks the optical channels that are being dropped from the WDM input signal and passes through those optical channels not being dropped onto the "through" path. In an "add" path within the node, optical channels are selectively added, such as by using optical multiplexing. Those optical channels from the multiplexed optical signal that are not designated for "add" (e.g., "unused" channels) are selectively blocked within the "add" transmission path. Optical channels from the "add" and "through" paths are then combined form a WDM output signal.

Genes and proteins, and their use

Suppression of coherent rayleigh noise in bidirectional communication systems

Low-noise, bidirectional communications in a fiber optic cable is achieved by coupling a first end of the cable to a spectrally-sliced optical power source. A second end of the cable is coupled to an optical detector having a detector bandwidth, such that the bandwidth of the optical power source is greater than the detector bandwidth. When the bandwidth of the optical power source is large compared to the bandwidth of the detector, the beat frequencies resulting from coherent Rayleigh noise fall outside the bandwidth of the detector and are not detected.

Attenuated gram negative bacteria

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed.

Attenuated gram negative bacteria

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed.

Method of controlling optical signal power at an add/drop node in a WDM optical communication system

Optical signal power levels for selected optical channels processed within an add/drop node in a wavelength division multiplexed (WDM) system are adjusted as a function of variations in signal power in an incoming WDM signal caused by gain ripple. In particular, a “ripple fitting” method is described whereby the optical signal power of individual optical channels being added at the add/drop node are adjusted to levels that correspond to the ripple profile of other optical channels being routed through the add/drop node. In this manner, the gain ripple in the WDM signal being output from the add/drop node approximately corresponds to the gain ripple in the incoming WDM signal at the node.

Outer surface proteins, their genes and their use

Ifølge foreliggende oppfinnelse, er en serie av gener identifisert i Gruppe B Streptococcus, produktene av hvilken kan være lokalisert på den ytre overflaten av organismen. Genene eller funksjonelle fragmenter derav, kan være anvendelige ved fremstilling av terapeutiske midler, f.eks. vaksiner for immuniseringen av en pasient mot mikrobiell infeksjon.

Attenuated gram negative bacteria

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed.

Streptococcus pyogenes virulenz gene und proteine und ihre verwendungen

Abgeschwächte gram-negative bakterien

Group b streptococcus proteine und deren verwendung

Aussermembranproteine, ihre gene, und deren verwendung

Verfahren zur Steuerung der optischen Signalleistung in einem Ausfüge/Einfüge-Knoten für ein WDM-Übertragungssystem

Verfahren zur Steuerung der optischen Signalleistung in einem Ausfüge/Einfüge-Knoten für ein WDM-Übertragungssystem

Method of controlling optical signal power at an add/drop node in a WDM optical communication system

Virulenzgene und deren proteine und verwendungen

Attenuated gram negative bacteria

Attenuirte gram-negative bakterien

Abgeschwächte gramnegative bakterien

Immunoassay for detecting group b streptococcus

Immunoadsorbent combinations for the detection and diagnosis of group B streptococcus polysaccharide antigen, comprising an insoluble carrier, a capture agent having an affinity for specifically binding to the trirhamnose epitope of group B streptococcus antigen and having the formula alpha -L-Rhap(1->2)- alpha -L-Rhap(1->2) alpha -Rhap-1- wherein Rhap is rhamnose, and an antigen marker agent having an affinity for binding to monorhamnose epitope of group B streptococcus polysaccharide antigen of formula alpha -L-Rhap-1- when the group B streptococcus polysaccharide is bound to the carrier. An immunoassay method test kit and polyclonal antibody are also described.

Πρωτεϊνες στρεπτοκοκκου ομαδας β, και η χρηση τους

Σύμφωνα με την παρούσα εφεύρεση, μία σειρά γονιδίων αναγνωρίζονται στην Ομάδα Β Στρεπτόκκοκου, τα προϊόντα της οποίας μπορούν να συνδέονται με την εξωτερική επιφάνεια του οργανισμού. Τα γονίδια, ή λειτουργικά θραύσματα αυτών, μπορούν να είναι χρήσιμα στην παρασκευή θεραπευτικών, π.χ. εμβολίων για την ανοσοποίηση ενός ασθενούς έναντι μικροβιακής λοίμωξης.

Streptococcus pyogenes virulenz gene und proteine und ihre verwendungen

三方向ユニバーサルバルブ

(57)【要約】 （修正有） 【課題】バルブを解除自在に開位置に保持する。 【解決手段】外部２からの空気の圧力がスプリング２４ に抗して、強制的にバルブの弾性膜２８を開き、空気が 中に入れるようにする。ロック機構３０、３０’、３２ は、捩ってロックを係合させ、開位置に保持するととも に、ロックを更に捩るか又は反対方向に捩ると、ロック の係合が解かれ、スプリング２４、ストローク及び内部 の空気圧でバルブが閉じられる。なお、バルブは、任意 のときに外部から押して開くことができ、それによって 内部４の圧力を調節することができる。

Programmable pixel shading architecture

Immunoassay for detecting group b streptococcus

Immunoassay for detecting group b streptococcus

Immunoadsorbent combinations for the detection and diagnosis of group B streptococcus polysaccharide antigen, comprising an insoluble carrier, a capture agent having an affinity for specifically binding to the trirhamnose epitope of group B streptococcus antigen and having the formula $g(a)-L-Rhap(1->2)-$g(a)-L-Rhap(1->2)$g(a)-Rhap-1- wherein Rhap is rhamnose, and an antigen marker agent having an affinity for binding to monorhamnose epitope of group B streptococcus polysaccharide antigen of formula $g(a)-L-Rhap-1- when the group B streptococcus polysaccharide is bound to the carrier. An immunoassay method test kit and polyclonal antibody are also described.

Immuntest zum nachweiss gruppe-b-streptokokkus

Immunoassay for detecting group b streptococcus

Immunoadsorbent combinations for the detection and diagnosis of group B streptococcus polysaccharide antigen, comprising an insoluble carrier, a capture agent having an affinity for specifically binding to the trirhamnose epitope of group B streptococcus antigen and having the formula alpha -L-Rhap(1->2)- alpha -L-Rhap(1->2) alpha -Rhap-1- wherein Rhap is rhamnose, and an antigen marker agent having an affinity for binding to monorhamnose epitope of group B streptococcus polysaccharide antigen of formula alpha -L-Rhap-1- when the group B streptococcus polysaccharide is bound to the carrier. An immunoassay method test kit and polyclonal antibody are also described.

Immuntest zum Nachweiss Gruppe-B-Streptokokkus

双方向通信システムにおけるコヒーレント・レイリー・ノイズの抑圧

(57)【要約】 【課題】 本発明は、光通信システムにおける光信号の 双方向伝送に関し、特に、双方向光通信システムにおい てコヒーレント・レイリー・ノイズを克服する技術を提 供することを目的とする。 【解決手段】本発明は、光ファイバ・ケーブルを使用し て低ノイズ双方向通信を提供するものであり、（ａ）該 ケーブルを、第１の帯域幅を有するスペクトル・スライ スされた光出力源に結合し、（ｂ）該第１の帯域幅が第 ２の帯域幅より大きくなるように、該ケーブルを該第２ の帯域幅を有する光検出器に結合する。これにより、光 出力源の帯域幅が検出器の帯域幅と比較して大きいと き、コヒーレント・レイリー・ノイズに起因するビート 周波数は検出器の帯域幅の外にあって検出されない。

Unterdrückung des kohärenten Rayleighrauschens in bidirektionalen Übertragungssystemen

Immunoadsorbent combination and assay to detect group b streptococcus polysaccharide antigen and immunoconjugate to raise antibodies to the antigen

Epithelial cell binding proteins obtainable from group b streptococcal strain and encoding dna

The present invention provides proteins that are important in bacterial infection, in particular Group B streptococcal infection. Also provided are gene sequences encoding the proteins, vaccines incorporating the proteins or attenuated microorganisms having a gene deletion, the gene encoding the proteins of the present invention.

Epithelial cell binding proteins obtainable from group b streptococcal strain and encoding dna

Programmable pixel shading architecture

A system and associated method are provided for processing pixel data in a graphics pipeline. Included is a triangle module coupled to a rasterizer for calculating a plurality of equations using pixel data received from the rasterizer. Also provided is a shader core module coupled to the rasterizer for receiving the pixel data therefrom. The shader core module is further coupled to the triangle module for receiving the equations therefrom. The shader core module functions to execute floating point calculations and generating texture coordinates using the pixel data. Coupled to the shader core module is a texture module. The texture module is capable of looking up texture values using the texture coordinates. Associated therewith is a shader back end module coupled to the texture module and the triangle module. The shader back end module is capable of converting the texture values to an appropriate floating point representation and generating color values using the equations. Still yet, a combiner module is coupled to the shader core module and the shader back end module. Such combiner module combines the color values and the texture values.

Programmable pixel shading architecture

A system and associated method are provided for processing pixel data in a graphics pipeline. Included is a triangle module coupled to a rasterizer for calculating a plurality of equations using pixel data received from the rasterizer. Also provided is a shader core module coupled to the rasterizer for receiving the pixel data therefrom. The shader core module is further coupled to the triangle module for receiving the equations therefrom. The shader core module functions to execute floating point calculations and generating texture coordinates using the pixel data. Coupled to the shader core module is a texture module. The texture module is capable of looking up texture values using the texture coordinates. Associated therewith is a shader back end module coupled to the texture module and the triangle module. The shader back end module is capable of converting the texture values to an appropriate floating point representation and generating color values using the equations. Still yet, a combiner module is coupled to the shader core module and the shader back end module. Such combiner module combines the color values and the texture values.

Programmable pixel shading architecture

A system and associated method are provided for processing pixel data in a graphics pipeline. Included is a triangle module coupled to a rasterizer for calculating a plurality of equations using pixel data received from the rasterizer. Also provided is a shader core module coupled to the rasterizer for receiving the pixel data therefrom. The shader core module is further coupled to the triangle module for receiving the equations therefrom. The shader core module functions to execute floating point calculations and generating texture coordinates using the pixel data. Coupled to the shader core module is a texture module. The texture module is capable of looking up texture values using the texture coordinates. Associated therewith is a shader back end module coupled to the texture module and the triangle module. The shader back end module is capable of converting the texture values to an appropriate floating point representation and generating color values using the equations. Still yet, a combiner module is coupled to the shader core module and the shader back end module. Such combiner module combines the color values and the texture values.

Nucleic acids and proteins from cenarchaeum symbiosum

The present application relates to nucleic acids and polypeptides from Cenarchaeum symbiosum . Methods of making the polypeptides and antibodies against the polypeptides are also described.

Nucleic acids and proteins from cenarchaeum symbiosum

The present application relates to nucleic acids and polypeptides from Cenarchaeum symbiosum . Methods of making the polypeptides and antibodies against the polypeptides are also described.

Nucleic acids and proteins from cenarchaeum symbiosum

The present application relates to nucleic acids and polypeptides from Cenarchaeum symbiosum. Methods of making the polypeptides and antibodies against the polypeptides are also described.

Nucleic acids and proteins from cenarchaeum symbiosum

The present application relates to nucleic acids and polypeptides from Cenarchaeum symbiosum. Methods of making the polypeptides and antibodies against the polypeptides are also described.

Verfahren zum Abtrennen von Fallungen bildenden Proteinen aus Serum

Clock data recovery system

A clock data recovery system is described. It includes a high pass filter for transmitting a filtered data signal in response to receiving an input data signal; an adder for summing the filtered data signal with a feedback signal, wherein the adder produces a summed input signal; a plurality of clocked data comparators for receiving the summed input signal, wherein the clocked data comparators determine an input data bit value; a plurality of clocked error comparators for receiving an error signal associated with clock recovery and DFE tap adaption; an equalization and adaptation logic for selecting an error sample such that a phase associated with the error sample is locked at h 0 =h 1 +h 2 ; and a phase mixer for transmitting a delay in response to receiving the phase and the delay is transmitted to the clocked-data comparators and the clocked-error comparators.