Method of selecting operation in a line-powered module

A line-powered module that is selectively operable in one of a plurality of modes of operation based upon the value of a selection signal. The line-powered module includes a control unit that selectively operates the module in one of the plurality of modes of operation based upon the value of a selection signal received by the control unit. The line-powered module includes a selection input that is coupled to the control unit such that the selection signal can be received at the selection input. Preferably, the selection input receives a selection wire that can be moved between different points of connection to define the plurality of states of the selection signal. Based upon the connection of the selection wire, the control unit operates the line-powered module in one of the plurality of modes of operation.

Intramedullary fixation system for management of pelvic and acetabular fractures

Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.

Deuterated compounds and uses thereof

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 1. A method of treating , preventing , or reducing a risk of a disease , disorder , condition , or cosmetic indication in which aldehyde toxicity is implicated in a subject in need thereof , comprising administering topically or systemically to the subject a compound comprising a primary amine , provided that the disease , disorder , or condition is not macular degeneration or Stargardt disease.2. The method of claim 1 , wherein the disease claim 1 , disorder claim 1 , or condition is an ocular disorder claim 1 , provided that the ocular disorder is not macular degeneration or Stargardt disease.3. The method of claim 2 , wherein the ocular disorder is selected from the group consisting of dry eye syndrome claim 2 , cataracts claim 2 , keratoconus claim 2 , bullous and other keratopathy claim 2 , Fuch's endothelial dystrophy claim 2 , allergic conjunctivitis claim 2 , ocular cicatricial pemphigoid claim 2 , conditions associated with PRK healing and other corneal healing claim 2 , conditions associated with tear lipid degradation or lacrimal gland dysfunction claim 2 , uveitis claim 2 , scleritis claim 2 , ocular Stevens Johnson Syndrome claim 2 , and ocular rosacea.4. The method of claim 3 , wherein the ocular disorder is dry eye syndrome.5. The method of claim 3 , wherein the ocular disorder is a condition associated with PRK healing and other corneal healing.6. The method of claim 3 , wherein the ocular disorder is selected from the group consisting of uveitis claim 3 , scleritis claim 3 , ocular Stevens Johnson Syndrome ...

Swivel drop ear elbow fitting

A swivel drop ear elbow fitting includes a threaded nut, a retaining ring, and a hollow elbow adapter. The threaded nut includes a plurality of integrated attachment ears located along an external periphery of the threaded nut. An outer surface of the first portion of the elbow adapter is shaped to receive the retaining ring, which retains the threaded nut on the first portion of the elbow adapter, while allowing the hollow elbow adapter to rotate with respect to the threaded nut.

INTRAMEDULLARY FIXATION SYSTEM FOR MANAGEMENT OF PELVIC AND ACETABULAR FRACTURES

Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.

Surface mount or low profile hazardous condition detector

A hazardous condition detector is provided. The hazardous condition detector comprises a body, a hazardous condition sensor, and at least one corona discharge apparatus. The body defines a passage therethrough. The passage extends between an inlet and an outlet. The hazardous condition sensor is positioned within the passage. The at least one corona discharge apparatus is positioned within the passage to draw a fluid into the passage through the inlet and to expel the fluid through the outlet.

Reuse in semiconductor measurement recipes

A semiconductor measurement recipe architecture organized to include reusable sub-recipes, each defining at least one parameter associated with either a semiconductor wafer and/or a semiconductor disposed thereon, is disclosed. This recipe architecture will include a set of parameter dependencies, one or more which having a respective relationship with of the sub-recipes to permit safe and reliable sub-recipe reuse. Also disclosed is a recipe generation method including: determining an appropriate baseline existing recipe that's organized to include a set of parameter dependencies and dependency related sub-recipes; perceiving a dependency change; determining which, if any, of the sub-recipes of the existing recipe remain unaffected after the dependency change(s); and generating a new recipe using at least one of the sub-recipes found to be unaffected.

ACCELERATING SEMICONDUCTOR-RELATED COMPUTATIONS USING LEARNING BASED MODELS

Methods and systems for performing one or more functions for a specimen using output simulated for the specimen are provided. One system includes one or more computer subsystems configured for acquiring output generated for a specimen by one or more detectors included in a tool configured to perform a process on the specimen. The system also includes one or more components executed by the one or more computer subsystems. The one or more components include a learning based model configured for performing one or more first functions using the acquired output as input to thereby generate simulated output for the specimen. The one or more computer subsystems are also configured for performing one or more second functions for the specimen using the simulated output. 1. A system configured to perform one or more functions for a specimen using output simulated for the specimen , comprising:one or more computer subsystems configured for acquiring output generated for a specimen by one or more detectors included in a tool configured to perform a process on the specimen; andone or more components executed by the one or more computer subsystems, wherein the one or more components comprise a learning based model configured for performing one or more first functions using the acquired output as input to thereby generate simulated output for the specimen, and wherein the one or more computer subsystems are further configured for performing one or more second functions for the specimen using the simulated output.2. The system of claim 1 , wherein the learning based model comprises a machine learning model.3. The system of claim 1 , wherein the learning based model comprises a deep learning model.4. The system of claim 1 , wherein the learning based model comprises a neural network.5. The system of claim 1 , wherein the learning based model comprises a convolution neural network.6. The system of claim 1 , wherein the learning based model comprises a deep neural network.7. The ...

COMBINATION TREATMENT OF OCULAR INFLAMMATORY DISORDERS AND DISEASES

The present disclosure provides a combination of a fused bicyclic amine compound and an anti-inflammatory agent for treating ocular inflammatory disorders and diseases. Further provided are pharmaceutical compositions of the compound and the anti-inflammatory agent. 4. The method of claim 1 , wherein the anti-inflammatory agent is selected from a steroid claim 1 , non-steroidal anti-inflammatory compound claim 1 , anti-metabolite claim 1 , immunosuppressive antibiotic claim 1 , alkylating agent claim 1 , and an anti-inflammatory cytokine antibody.517-. (canceled)18. The method of claim 1 , wherein the ocular inflammatory disorder or disease is selected from: allergic conjunctivitis; vernal keratoconjunctivitis; atopic keratoconjunctivitis; dry eye syndrome; meibomian gland dysfunction; cataracts; keratoconus; bullous and other keratopathy; Fuch's endothelial dystrophy; ocular cicatricial pemphigoid; conditions associated with photoreactive keratotomy (PRK) healing and other corneal healing; conditions associated with tear lipid degradation or lacrimal gland dysfunction; uveitis; anterior uveitis; intermediate uveitis; posterior uveitis; panuveitis claim 1 , non-infectious uveitis; infectious uveitis; keratitis; scleritis; iritis; cyclitis; ocular graft versus host disease (GVHD); optic neuritis; ocular Stevens Johnson Syndrome; blepharitis; ocular rosacea claim 1 , with or without meibomian gland dysfunction; post cataract procedure; persistent corneal erosion; and inflammation associated with corneal trauma claim 1 , corneal transplantation claim 1 , and refractive surgery.1925-. (canceled)26. The method of claim 1 , wherein the compound is formulated with a cyclodextrin.2743-. (canceled)47. The pharmaceutical composition of claim 44 , wherein the anti-inflammatory agent is selected from a steroid claim 44 , non-steroidal anti-inflammatory compound claim 44 , anti-metabolite claim 44 , immunosuppressive antibiotic claim 44 , and alkylating agent.4861-. (canceled)65 ...

WALL-MOUNTED WATER CLOSET CARRIER ASSEMBLY

A water closet carrier assembly for mounting a water closet having an outlet to a plurality of wall members includes a faceplate having a central portion extending in a widthwise direction between a first side and a second side, and a water closet outlet opening configured to align with an outlet of the water closet, a first side portion coupled to the central portion at the first side, the first side portion including a first side portion mounting aperture, and a second side portion coupled to the central portion at the second side, the second side portion including a second side portion mounting aperture. The water closet carrier assembly also includes first and second fasteners configured to couple the first and second side portions, respectively, to first and second wall members, respectively, of the plurality of wall members. The faceplate is supported solely by the plurality of wall members.

Accelerated training of a machine learning based model for semiconductor applications

Methods and systems for accelerated training of a machine learning based model for semiconductor applications are provided. One method for training a machine learning based model includes acquiring information for non-nominal instances of specimen(s) on which a process is performed. The machine learning based model is configured for performing simulation(s) for the specimens. The machine learning based model is trained with only information for nominal instances of additional specimen(s). The method also includes re-training the machine learning based model with the information for the non-nominal instances of the specimen(s) thereby performing transfer learning of the information for the non-nominal instances of the specimen(s) to the machine learning based model.

DEUTERATED COMPOUNDS AND USES THEREOF

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 29-. (canceled)10. The compound according to claim 1 , wherein Ris —CD.1113-. (canceled)14. The compound according to claim 10 , wherein Ris —CD.1519-. (canceled)22. A composition comprising a compound according to and a pharmaceutically acceptable adjuvant claim 1 , carrier claim 1 , or vehicle.23. The composition according to claim 22 , in combination with an additional therapeutic agent.24. (canceled)25. A method of treating claim 1 , preventing claim 1 , or reducing a risk of a disease claim 1 , disorder claim 1 , condition claim 1 , or cosmetic indication in which aldehyde toxicity is implicated in a subject in need thereof claim 1 , comprising administering topically or systemically to the subject a composition comprising a compound according to .26. The method of claim 25 , wherein the disease claim 25 , disorder claim 25 , or condition is an ocular disorder.27. The method of claim 26 , wherein the ocular disorder is selected from macular degeneration or Stargardt disease.28. The method of claim 26 , wherein the ocular disorder is selected from the group consisting of dry eye syndrome claim 26 , cataracts claim 26 , keratoconus claim 26 , bullous and other keratopathy claim 26 , Fuch's endothelial dystrophy claim 26 , allergic conjunctivitis claim 26 , ocular cicatricial pemphigoid claim 26 , conditions associated with PRK healing and other corneal healing claim 26 , conditions associated with tear lipid degradation or lacrimal gland dysfunction claim 26 , uveitis claim 26 , scleritis claim 26 , ocular Stevens Johnson ...

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 142-. (canceled)44. The method of claim 43 , wherein p is 1.45. The method of claim 43 , wherein each Qis methyl.46. The method of claim 43 , wherein Ris a halogen.47. The method of claim 46 , wherein the halogen is chlorine or fluorine.48. The method of claim 47 , wherein the halogen is chlorine.49. The method of claim 43 , wherein the compound is present at a concentration of about 0.05-10% w/v.50. The method of claim 43 , wherein the compound is present at a concentration of about 0.1-5% w/v.51. The method of claim 43 , wherein the compound is present at a concentration of about 0.1-2% w/v.52. The method of claim 43 , wherein the compound is present at a concentration of about 0.1-1.0% w/v.53. The method of claim 43 , wherein the compound is present at a concentration of about 0.09-0.5% w/v.54. The method of claim 43 , wherein the compound is present in an admixture with a cyclodextrin.55. The method of claim 54 , wherein the cyclodextrin comprises a β-cyclodextrin or a pharmaceutically acceptable salt thereof.56. The method of claim 55 , wherein the β-cyclodextrin is selected from the group consisting of sulfobutylether-β-cyclodextrin claim 55 , 2-hydroxypropyl-β-cyclodextrin claim 55 , and 3-hydroxypropyl-β-cyclodextrin.57. The method of claim 56 , wherein the β-cyclodextrin is sulfobutylether-β-cyclodextrin or a pharmaceutically acceptable salt thereof.58. The method of claim 57 , wherein the salt of sulfobutylether-β-cyclodextrin is sulfobutylether-β-cyclodextrin sodium salt.59. The method of claim 58 , wherein the ...

Methods for modulating tumor growth and metastasis

Methods and pharmaceutical compositions for modulating tumor growth or metastasis and methods for prognosing treatment therewith are provided.

Toxic aldehyde related diseases and treatment

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Compositions and method for modulation of gene expression in plants

An enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of an gene in a plant. A transgenic plant comprising nucleic acids encoding for an enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of a gene in said plant.

Accelerating semiconductor-related computations using learning based models

Methods and systems for performing one or more functions for a specimen using output simulated for the specimen are provided. One system includes one or more computer subsystems configured for acquiring output generated for a specimen by one or more detectors included in a tool configured to perform a process on the specimen. The system also includes one or more components executed by the one or more computer subsystems. The one or more components include a learning based model configured for performing one or more first functions using the acquired output as input to thereby generate simulated output for the specimen. The one or more computer subsystems are also configured for performing one or more second functions for the specimen using the simulated output.

COMPOSITIONS AND METHODS FOR PROTEIN DETECTION

The invention relates generally to peptide biomarkers with specific ionization characteristics to directly quantify one or more transgenic target proteins in biological samples, including transgenic plant samples, by liquid chromatography coupled tandem mass spectrometry multiple reaction monitoring (MRM). The peptide biomarkers in combination with MRM-based methods may be used to quantify a single transgenic target protein or multiple transgenic target proteins within a stacked transgenic crop, such as maize, utilizing selected peptide biomarkers either alone or in combination. The present disclosure allows for broad based, reliable quantitation in different biological matrices, including plant matrices. The peptide biomarkers of the invention can further be used as trait biomarkers to support identification and/or selection of specific transgenic Events. Also provided are different peptide biomarker combinations that can be used to perform the methods of the invention. 2. The labeled surrogate peptide of claim 1 , wherein the peptide is labeled by incorporation of a stable isotope labeled (SIL) amino acid.3. The labeled surrogate peptide of claim 2 , wherein the SIL amino acid is lysine claim 2 , isoleucine claim 2 , valine or arginine.4. (canceled)5. (canceled)6. (canceled)7. The surrogate peptide of claim 1 , wherein said peptide selectively detects or quantitates an eCry3.1Ab protein and comprises an amino acid sequence selected from the group consisting of TDVTDYHIDQV (SEQ ID NO:27) claim 1 , AVNELFTSSNQIGLK (SEQ ID NO:28) claim 1 , ITQLPLTK (SEQ ID NO:29) claim 1 , GLDSSTTK (SEQ ID NO:30) claim 1 , QCAGIRPYDGR (SEQ ID NO:31) and IEFVPAEVTFEAEYDLER (SEQ ID NO:32).8. The surrogate peptide of claim 7 , wherein said peptide produces a transition ion having an amino acid sequence selected from the group consisting of TDYHIDQV (SEQ ID NO:142) claim 7 , DYHIDQV (SEQ ID NO:143) claim 7 , TSSNQIGLK (SEQ ID NO:144) claim 7 , SSNQIGLK (SEQ ID NO:145) claim 7 , QLPLTK ( ...

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

INTRAMEDULLARY FIXATION SYSTEM FOR MANAGEMENT OF PELVIC AND ACETABULAR FRACTURES

Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated. 191.-. (canceled)92. A device , comprising:segments forming a flexible body having first and second body ends and being configurable in a curved shape;at least one axial opening formed in the segments;flexible members disposed in at least one of the at least one axial opening, each flexible member configured to move relative to at least one of the segments along an axial direction as the flexible body is being manipulated into a curved shape; anda mechanism disposed at one of the first and second body ends and being configurable to prohibit the flexible members from moving relative to one another to lock the flexible body in a curved shape.93. The device of wherein at least one of the segments includes a segment end that is engaged with a segment end of another one of the segments.94. The device of wherein at least one of the segments includes first and second segment ends having approximately a same shape.95. The device of wherein at least one of the segments includes a segment end having a portion that is disposed within a portion of a segment end of another one of the segments.96. The device of wherein at least one of the at least one axial opening extends through a respective center of each of the segments.97. The device of wherein the flexible members comprise respective rods.98. The device of wherein at least one of the flexible members is configured to move relative to at least another of the flexible members along the axial direction as the flexible body is being ...

ACCELERATED TRAINING OF A MACHINE LEARNING BASED MODEL FOR SEMICONDUCTOR APPLICATIONS

Methods and systems for accelerated training of a machine learning based model for semiconductor applications are provided. One method for training a machine learning based model includes acquiring information for non-nominal instances of specimen(s) on which a process is performed. The machine learning based model is configured for performing simulation(s) for the specimens. The machine learning based model is trained with only information for nominal instances of additional specimen(s). The method also includes re-training the machine learning based model with the information for the non-nominal instances of the specimen(s) thereby performing transfer learning of the information for the non-nominal instances of the specimen(s) to the machine learning based model. 1. A system configured to train a machine learning based model , comprising:one or more computer subsystems; and 'a machine learning based model configured for performing one or more simulations for specimens, wherein the machine learning based model is trained with only information for nominal instances of one or more of the specimens;', 'one or more components executed by the one or more computer subsystems, wherein the one or more components comprise acquiring information for non-nominal instances of one or more of the specimens on which a process is performed; and', 're-training the machine learning based model with the information for the non-nominal instances of the one or more of the specimens thereby performing transfer learning of the information for the non-nominal instances of the one or more of the specimens to the machine learning based model., 'wherein the one or more computer subsystems are configured for2. The system of claim 1 , wherein performing the one or more simulations comprises generating one or more simulated images for one of the specimens claim 1 , and wherein the one or more simulated images illustrate how the one of the specimens appears in one or more actual images of the one ...

Systems and methods of split billing

A method includes receiving input during execution of a first application at an electronic device. The input indicates that data usage of the electronic device is to be billed to a first data usage account of a plurality of data usage accounts associated with the electronic device. The method further includes generating a request during execution of a second application at the electronic device. The method also includes, based on the input, encapsulating, by the electronic device, the request to generate an encapsulated request that identifies a destination endpoint provisioned for the first data usage account. The method further includes transmitting the encapsulated request from the electronic device to a network element.

WATER-SOLUBLE FORMULATIONS, METHODS OF MAKING AND USE

Water-soluble formulations including cannabinoids or a -derived compound for use in beverages and foods, methods of preparing the formulations, and methods of preparing beverages and foods including the formulations are disclosed herein. In some embodiments, the water-soluble formulations comprise a cannabinoid or a -derived compound; an emulsifier comprising Quillaja saponins; a carrier oil, and a glycerin-based carrier surfactant. 1cannabis. A water-soluble formulation comprising a cannabinoid or a -derived compound; an emulsifier comprising Quillaja saponins; a carrier oil , and a glycerin-based carrier surfactant.2. The water-soluble formulation of claim 1 , wherein the emulsifier comprising Quillaja saponins is a Q-NATURALE® emulsifier claim 1 , Saponin from Quillaja Bark claim 1 , Saponin Quillaja sp. claim 1 , a Quillaja extract claim 1 , purified Quillaja saponins claim 1 , or any combination thereof.3. The water-soluble formulation of claim 2 , wherein the emulsifier comprising Quillaja saponins is a Q-NATURALE® emulsifier.4. The water-soluble formulation of claim 1 , wherein the carrier oil is comprised of monoglycerides or medium chain triglycerides.5. The water-soluble formulation of claim 4 , wherein the carrier oil is comprised of monoglycerides claim 4 , and the monoglycerides comprise glyceryl monostearate claim 4 , glyceryl hydroxystearate claim 4 , glyceryl monoleate claim 4 , winterized glyceryl monoleate claim 4 , monolaurin claim 4 , glyceryl monolinoleate claim 4 , or any combination thereof.6cannabis. The water-soluble formulation of claim 1 , which comprises up to 10% by weight of the cannabinoid or -derived compound claim 1 , up to 15% by weight of the emulsifier comprising Quillaja saponins claim 1 , and up to 10% by weight of the carrier oil.7. The water-soluble formulation of claim 1 , which comprises a ratio of glycerin-based carrier surfactant:emulsifier comprising Quillaja saponins of between about 25:1 and about 5:1.8. The water- ...

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 142-. (canceled)44. The method of claim 43 , wherein p is 1.45. The method of claim 43 , wherein each Qis methyl.46. The method of claim 43 , wherein Ris a halogen.47. The method of claim 46 , wherein the halogen is chlorine or fluorine.48. The method of claim 47 , wherein the halogen is chlorine.49. The method of claim 43 , wherein the compound is present at a concentration from about 0.05-10% w/v.50. The method of claim 43 , wherein the compound is present at a concentration from about 0.1-5% w/v.51. The method of claim 43 , wherein the compound is present at a concentration from about 0.1-2% w/v.52. The method of claim 43 , wherein the compound is present at a concentration from about 0.1-1.0% w/v.53. The method of claim 43 , wherein the compound is present at a concentration from about 0.09-0.5% w/v.54. The method of claim 43 , wherein the compound is present in an admixture with a cyclodextrin.55. The method of claim 54 , wherein the cyclodextrin comprises ar3-cyclodextrin or a pharmaceutically acceptable salt thereof.56. The method of claim 55 , wherein the β-cyclodextrin is selected from the group consisting of sulfobutylether-β-cyclodextrin claim 55 , 2-hydroxypropyl-β-cyclodextrin claim 55 , and 3-hydroxypropyl-β-cyclodextrin.57. The method of claim 56 , wherein the β-cyclodextrin is sulfobutylether-β-cyclodextrin or a pharmaceutically acceptable salt thereof.58. The method of claim 57 , wherein the salt of sulfobutylether-β-cyclodextrin is sulfobutylether-β-cyclodextrin sodium salt.59. The method of claim 58 , ...

Apparatus for use in unpacking shipping containers

An apparatus (600) for use in unpacking or packing shipping containers (700) includes at least one barrier part which provides a barrier to wheeled powered material handling equipment (1105). The barrier part can be positioned substantially transversely across an interior of a shipping container (700) at a desired position along the length of the interior of the shipping container, to provide a working area (1120) within the shipping container in which personnel may work on foot, and substantially impede or prevent entry of wheeled powered material handling equipment into the working area. The apparatus may be provided with an arrangement to substantially maintain its location in the desired position against forces resulting from impact by the powered material handling equipment operating within the shipping container.

NON-ANTIBODY LIGANDS FOR DETECTING TARGET PROTEINS

The invention relates generally to synthetic non-antibody protein scaffolds (synNAPS) that differentially detect or quantitate a target insecticidal protein in a complex biological matrix comprising the target protein and a non-target insecticidal protein and to methods of using the synNAPS in immunoassays, and more particularly to monoclonal antibodies and immunoassays for the differential detection and quantitation of a wild-type crystal protein, such as a wild-type-Cry1Ab, from and hybrid crystal proteins, which comprise all or a significant portion of the wild-type Cry protein in complex biological samples comprising both the wild-type Cry protein and one or more of the hybrid Cry proteins. 1. A synthetic non-antibody protein scaffold (synNAPS) , or an antigen-binding fragment thereof , that binds to an insecticidal protein and optionally comprises an amino acid tag.2. The synNAPS of claim 1 , wherein the insecticidal protein comprises an amino acid sequence of any of SEQ ID NOs:1-7 or a ligand-binding fragment of any of SEQ ID NOs:1-7.3. The synNAPS of claim 2 , wherein the synNAPS comprises any of SEQ ID NOs:10-17 claim 2 , 19 claim 2 , 21 claim 2 , 24-31 claim 2 , 33 or 35.4. The synNAPS of claim 1 , wherein the synNAPS comprises an amino acid sequence that has from at least 80% to at least 99% sequence identity to SEQ ID NO:10 claim 1 , SEQ ID NO:17 or SEQ ID NO:21 and wherein the amino acid sequence that has from at least 80% to at least 99% sequence identity to (a) SEQ ID NO:10 has a W at a position corresponding to or at position 22 of SEQ ID NO:10 claim 1 , a S at a position corresponding to or at position 29 of SEQ ID NO:10 claim 1 , a Y at a position corresponding to or at position 31 of SEQ ID NO:10 and a R at a position corresponding to or at position 44 of SEQ ID NO:10; or (b) SEQ ID NO:17 has an I at a position corresponding to or at position 29 of SEQ ID NO:17 and a F at a position corresponding to or at position 42 of SEQ ID NO:17; or (c) SEQ ID ...

APPARATUS AND METHOD FOR FILLING FLANGELESS CONTAINERS

A finger grip for a flangeless container, the finger grip having a skirt removably attachable to an open end portion of the container and a lip that extends radially outwardly from the skirt. The flangeless container is fillable by capping the container using a cap element to attach the finger grip to the container; installing the container in a container support assembly including a tray having a plurality of wells; filling the container; inserting a piston into the container; and removing the finger grip. Each well has a depth less than a predetermined length of the container, a lower portion of each well having a first cross-sectional shape similar to but greater than the cross-sectional shape of the flangeless container, an upper portion of each well having a second cross-sectional shape similar to but greater than the first cross-sectional shape.

DEUTERATED COMPOUNDS AND USES THEREOF

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Confocal wafer inspection method and apparatus

A semiconductor wafer inspection system and method is provided which uses a multiple element arrangement, such as an offset fly lens array. The preferred embodiment uses a laser to transmit light energy toward a beam expander, which expands the light energy to create an illumination field. An offset fly lens array converts light energy from the illumination field into an offset pattern of illumination spots. A lensing arrangement, including a first lens, a transmitter/reflector, an objective, and a Mag tube imparts light energy onto the specimen and passes the light energy toward a pinhole mask. The pinhole mask is mechanically aligned with the offset fly lens array. Light energy passing through each pinhole in the pinhole mask is directed toward a relay lens, which guides light energy onto a sensor. The offset fly lens array corresponds to the pinhole mask. The offset pattern of the offset fly lens array is chosen such that spots produced can be recombined into a continuous image, and the system utilizes a time delay and integration charge coupled device for rapid sensing along with an autofocus system that measures and cancels topological features of the specimen.

Control of acute hypertension and cardiotoxicity in patients treated with vascular targeting agents

The present invention provides a method of using anti-hypertensive agents ("AHAs") to attenuate the transient increase in blood pressure observed in patients where Vascular Targeting Agents ("VTAs") are administered to treat diseases associated with malignant neovascularization. The invention also relates to pharmaceutical compositions comprising AHAs and VTAs, and to kits thereof.

HYBRID INSPECTORS

Hybrid inspectors are provided. One system includes computer subsystems) configured for receiving optical based output and electron beam based output generated for a specimen. The computer subsystem(s) include one or more virtual systems configured for performing one or more functions using at least some of the optical based output and the electron beam based output generated for the specimen. The system also includes one or more components executed by the computer subsystem(s), which include one or more models configured for performing one or more simulations for the specimen. The computer subsystem(s) are configured for detecting defects on the specimen based on at least two of the optical based output, the electron beam based output, results of the one or more functions, and results of the one or more simulations.

Massage speaker unit

A portable sound and vibration transmission device, compatible with common audio producing means, designed to enhance the relaxation experienced by a massage therapy client through the use of an upward facing subwoofer and distal cylinders containing speaker drivers positioned to create a surround sound effect.

Vacuum package system

A vacuum packaging system for transporting a plurality of medical containers includes a plurality of medical a tray that receives and supports the medical containers. The tray includes opposing first and second side walls, opposing side and rear walls and a bottom floor. The walls extend generally perpendicularly from the bottom floor of the tray to a top edge thereof. A nesting plate is removably mountable in the tray and includes a plurality of generally cylindrical sleeves each receiving one of the plurality of medical containers. A support surface within the tray generally extends parallel to and spaced a predetermined distance from the bottom floor of the tray and receives and supports the nesting plate. An air impervious flexible film defines an internal cavity and completely surrounds the tray and the medical containers. The internal cavity is evacuated to and maintained at a predetermined vacuum level below atmospheric pressure.

COMPOSITIONS AND METHODS FOR PROTEIN DETECTION

The invention relates generally to peptide biomarkers with specific ionization characteristics to directly quantify one or more target HPPD proteins in biological samples, including crop plant samples, by liquid chromatography coupled tandem mass spectrometry multiple reaction monitoring (MRM). The peptide biomarkers in combination with MRM-based methods may be used to quantify a single target protein or multiple target proteins within a crop plant, such as maize, utilizing selected peptide biomarkers either alone or in combination. The present disclosure allows for broad based, reliable quantitation in different biological matrices, including plant matrices. Also provided are different peptide biomarker combinations that can be used to perform the methods of the invention.

Recovery of Client Clock Without Jitter

The present invention provides a system, apparatus and method for recovering a client signal clock. The present invention is able to more effectively remove jitter within a clock signal by providing a phase shifting element in the feedback of a PLL system to compensate for sudden changes in an input reference clock. The PLL system provides flexible clock recovery so that it can accommodate various payload types because it extracts a client clock signal independent of a corresponding justification count number.

Stereo Extended Depth of Focus

The disclosure is directed to providing high resolution stereoscopy with extended depth of focus. Wave front coding in optical paths going to a first detector and at least a second detector may be implemented to affect an intermediate set of images. The intermediate set of images may be filtered (i.e. decoded) to produce a filtered set of images with selected resolution and depth of focus properties. A first filtered image and a second filtered image may be substantially simultaneously presented to respective first and second eyes of an observer to further generate an illusion of enhanced depth (i.e. 3D perception). 1. A system for stereoscopically imaging at least a portion of one or more samples , comprising:a stage configured to support a sample;an illumination source configured to illuminate at least a portion of the sample;collection optics defining a collection path, the collection optics configured to receive illumination transmitted through or reflected from a surface of the sample, and further configured to direct a first portion of the illumination along a first imaging path to a first detector and a second portion of the illumination along a second imaging path to a second detector;a wave front coder disposed along the collection path, the wave front coder configured to induce one or more imaging effects, at least by phase shifting the illumination directed along the collection path; andat least one computing system communicatively coupled to the first detector and the second detector, the at least one computing system configured to acquire a first image from the first detector and a second image from the second detector, and further configured to filter the first image and the second image to remove at least a portion of the one or more imaging effects induced by the wave front coder.2. The system of claim 1 , further comprising:at least one stereoscopic display configured to substantially simultaneously display the first filtered image and the second ...

Stereo extended depth of focus

The disclosure is directed to providing high resolution stereoscopy with extended depth of focus. Wave front coding in optical paths going to a first detector and at least a second detector may be implemented to affect an intermediate set of images. The intermediate set of images may be filtered (i.e. decoded) to produce a filtered set of images with selected resolution and depth of focus properties. A first filtered image and a second filtered image may be substantially simultaneously presented to respective first and second eyes of an observer to further generate an illusion of enhanced depth (i.e. 3D perception).

APPARATUS FOR USE IN UNPACKING SHIPPING CONTAINERS

An apparatus () for use in unpacking or packing shipping containers () includes at least one barrier part which provides a barrier to wheeled powered material handling equipment (). The barrier part can be positioned substantially transversely across an interior of a shipping container () at a desired position along the length of the interior of the shipping container, to provide a working area () within the shipping container in which personnel may work on foot, and substantially impede or prevent entry of wheeled powered material handling equipment into the working area. The apparatus may be provided with an arrangement to substantially maintain its location in the desired position against forces resulting from impact by the powered material handling equipment operating within the shipping container. 1. A moveable platform for use inside a shipping container in unpacking or packing the shipping container , the moveable platform comprising:a platform surface upon which a user can stand and move around while unpacking or packing the shipping container, and upon which cargo can also be placed as it is being unpacked from the shipping container by the user or as it is being packed into the shipping container by the user;at least one barrier part which provides a barrier to wheeled powered material handling equipment moving onto the platform surface; andan arrangement to substantially maintain the moveable platform in a desired position inside the shipping container against forces resulting from impact by powered material handling equipment, the arrangement comprising one or more portions located on opposed sides of the moveable platform that are operable to selectively engage in recesses of respective first and second side walls of the shipping container so as to secure the movable platform against movement within the shipping container.2. The safety apparatus according to claim 1 , wherein the barrier part is provided by a height of the platform surface being greater ...

Deuterated compounds and uses thereof

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

APPARATUS FOR USE IN UNPACKING SHIPPING CONTAINERS

An apparatus () for use in unpacking or packing shipping containers () includes at least one barrier part which provides a barrier to wheeled powered material handling equipment (). The barrier part can be positioned substantially transversely across an interior of a shipping container () at a desired position along the length of the interior of the shipping container, to provide a working area () within the shipping container in which personnel may work on foot, and substantially impede or prevent entry of wheeled powered material handling equipment into the working area. The apparatus may be provided with an arrangement to substantially maintain its location in the desired position against forces resulting from impact by the powered material handling equipment operating within the shipping container. 1. An apparatus for use in unpacking or packing shipping containers comprising:at least one barrier part which provides a barrier to wheeled powered material handling equipment, the barrier part being adapted to be positioned substantially transversely across an interior of a shipping container at a desired position along the length of the interior of the shipping container, and the apparatus being provided with an arrangement adapted, in use, to substantially maintain its location in the desired position against forces resulting from impact by powered material handling equipment operating within the shipping container.2. An apparatus according to claim 1 , wherein the apparatus comprises a moveable platform providing a platform surface claim 1 , the moveable platform being dimensioned to provide a safety area of the platform surface claim 1 , the safety area being spaced from the barrier part by at least one metre.3. An apparatus according to claim 2 , wherein the arrangement to substantially maintain the location of the apparatus in the desired position comprises at least one brake associated with a wheel of the apparatus.4. An apparatus according to claim 2 , ...

INTRAMEDULLARY FIXATION SYSTEM FOR MANAGEMENT OF PELVIC AND ACETABULAR FRACTURES

Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated. 1. A device for treating a bone , the device comprising:a flexible tube having a distal end and a proximal end;a stiffening mechanism within the flexible tube configured to cause the flexible tube to become rigid; andan actuator configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.2. The device of claim 1 , wherein the flexible tube comprises a series of slits configured to allow the tube to flex.3. The device of claim 1 , wherein the flexible tube comprises stainless steel claim 1 , nitinol or a combination thereof4. The device of claim 1 , further comprising a screw positioned at the distal end of the flexible tube.5. The device of claim 1 , wherein:the actuator comprises a cap connected to the proximal end of the flexible tube; andthe cap is configured to permit the flexible tube to be rotated.6. The device of claim 5 , wherein:the stiffening mechanism comprises a plurality of expansion sleeves;each of the plurality of expansion sleeves comprises a bore; andthe cap is further configured to cause each of the plurality of expansion sleeves to abut an interior surface of the flexible tube in response to the cap being rotated.7. The device of claim 6 , wherein an expansion sleeve of the plurality of expansion sleeves comprises a spring.8. The device of claim 6 , wherein an expansion sleeve of the plurality of expansion sleeves comprises one or more jam nuts.9. The device of claim 6 , wherein an ...

Medical Container

The present invention relates to a medical container useful upon transportation of plural syringe barrels. The medical container includes at least a container main body and a holding member arranged inside the container main body. The holding member is provided at least with a plurality of cylindrical holding portions for holding syringe barrels. The container main body has at least a peripheral rim arranged on and along an outer periphery of an opening and a shoulder-shaped portion arranged on an inner wall of the container to arrange the holding member. The shoulder-shaped portion has at least three ribs for supporting the holding member, and has a structure that enables to arrange via the ribs the holding member in a horizontal position relative to a bottom wall of the container main body. According to the present invention, there is provided a medical container of a construction that can be promptly brought into a sterilized state by various methods, can be readily brought into a state ...

Xenorhabdus TC proteins and genes for pest control

The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. This exochitinase can be used to control insects using methods known in the art.

Digital pathology system

The present invention may include an illumination source; a TDI sensor having a plurality of rows of TDI pixels, wherein each of the TDI pixels have a 1:1 aspect ratio; a multicolor filter contacted to the surface of the TDI sensor, wherein the multicolor filter has alternating sections of a first color filter, a second color filter, and at least a third color, wherein adjacent rows of TDI pixels are grouped in order to form a plurality of rows of integrated multicolor pixels; an objective having a first end positioned proximate to the specimen; a second lens configured to focus light from the image path onto the TDI sensor; and an anamorphic optics element configured to magnify an image of the one or more specimens such that the image is magnified by a factor of three along a direction orthogonal to an integrating direction of the TDI sensor.

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

KEG CLEANING SYSTEM AND METHOD

A keg cleaning system and method is provided. The keg cleaning system and method is operable to first pump a fluid cleaner through an intake of a keg coupler and into a keg at a high pressure. The liquid cleaner is pumped into the keg for a short period of time. After the liquid cleaner has been pumped into the keg, CO2 or air is then pumped through the intake of the keg coupler and into the keg at a high pressure for a short period of time. The liquid cleaner is then forced out of a keg coupler exhaust. The steps are repeated until the inside of the keg is clean. Due to the repeated surges from the pump and the surges from the air or CO2 the inside of the keg is thoroughly cleaned. 1. A method of cleaning a keg comprising the steps of:pumping a fluid cleaner through an intake of a keg coupler and into a keg for a first period of time comprising at least 1 second;ending the pumping of the fluid cleaner into the keg after the first period of time has expired; andspraying a pressurized gas through the intake of the keg coupler and into the keg after the fluid cleaner is no longer being pumped into the keg, wherein the pressurized gas is sprayed into the keg for a second period of time comprising at least 1 second, whereinthe fluid cleaner exits the keg when the pressurized gas is pumped into the keg.2. The method of claim 1 , wherein the fluid cleaner exits a keg coupler exhaust when the pressurized gas is pumped into the keg.3. The method of claim 1 , wherein the first period of time and the second period of time each comprise at least 1 second up to and 15 seconds.4. The method of claim 1 , wherein the first period of time and the second period of time each comprise at least 1 second and up to 10 seconds.5. The method of claim 1 , further comprising the step of: repeating the steps of until an inside of the keg is clean.6. The method of claim 1 , wherein the pressurized gas comprises one of air and CO2.7. A method of cleaning a keg comprising the steps of: a first ...

DEUTERATED COMPOUNDS AND USES THEREOF

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 145-. (canceled)47. The compound of claim 46 , wherein at least one of R claim 46 , R claim 46 , R claim 46 , R claim 46 , R claim 46 , R claim 46 , or Ris deuterium.48. The compound of claim 46 , wherein the compound is of Formula II-A claim 46 , or a pharmaceutically acceptable salt thereof.49. The compound of claim 48 , wherein at least one of R claim 48 , R claim 48 , R claim 48 , R claim 48 , R claim 48 , R claim 48 , or Ris deuterium.52. A pharmaceutical composition comprising the compound of claim 46 , or a pharmaceutically acceptable salt thereof claim 46 , and a pharmaceutically acceptable adjuvant claim 46 , carrier claim 46 , or vehicle.53. A pharmaceutical composition comprising the compound of claim 51 , or a pharmaceutically acceptable salt thereof claim 51 , and a pharmaceutically acceptable adjuvant claim 51 , carrier claim 51 , or vehicle.54. A method of treating a disease claim 46 , disorder claim 46 , condition claim 46 , or cosmetic indication in which aldehyde toxicity is implicated in a subject in need thereof claim 46 , comprising administering topically or systemically to the subject a composition comprising a compound according to .55. The method of claim 54 , wherein the disease claim 54 , disorder claim 54 , or condition is an ocular disorder.56. The method of claim 55 , wherein the ocular disorder is macular degeneration or Stargardt disease.57. The method of claim 55 , wherein the ocular disorder is selected from the group consisting of dry eye syndrome claim 55 , cataracts claim 55 , keratoconus ...

ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF

The present invention provides compounds and methods for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Multifunctional relay module for use with CO and smoke alarms

A multi-function relay module for use with a series of hazardous condition detectors that are interconnected by an interconnect line. The relay module is positioned between the interconnected hazardous condition detectors and one or more auxiliary devices such that the relay module can selectively activate each of the auxiliary devices. The relay module receives the interconnect signal and determines whether the interconnect signal is indicating a first sensed condition or a second sensed condition. A selection signal having multiple states is received by the control unit. The control unit is programmed to respond to the type of sensed condition indicated by the interconnect signal based upon the state of the selection signal. Thus, the relay module can selectively respond to either the first sensed condition, the second sensed condition or either of the first or second sensed conditions.

DEUTERATED COMPOUNDS AND USES THEREOF

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Intramedullary fixation system for management of pelvic and acetabular fractures

Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.

Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples

Mass spectrometry-based methods are described for the detection or quantification of targeted proteins in biological samples e.g., plants, animals, and microorganisms, parts (e.g., tissue or cells) thereof, and products derived from plants, animals or microorganisms.

APPLICATION OF HARDWARE-BASED MAILBOXES IN NETWORK TRANSCEIVERS AND DISTRIBUTED APPROACH FOR PREDICTABLE SOFTWARE-BASED PROTECTION SWITCHING

A line card in a network node having a local memory coupled to a local controller and local logic circuit. The local memory in the line card stores state information for signals processed by the line card itself, as well as state information for signals processed by other line cards. The logic circuit and controller implement a same fault detection and signal processing algorithms as all other line cards in the group, to essentially effectuate a distributed and local hardware based control of automatic protection switching (APS) without interrupting a central processor. The line card also performs error checking and supervisory functions to ensure consistency of state among the line cards.

Hybrid inspectors

Hybrid inspectors are provided. One system includes computer subsystem(s) configured for receiving optical based output and electron beam based output generated for a specimen. The computer subsystem(s) include one or more virtual systems configured for performing one or more functions using at least some of the optical based output and the electron beam based output generated for the specimen. The system also includes one or more components executed by the computer subsystem(s), which include one or more models configured for performing one or more simulations for the specimen. The computer subsystem(s) are configured for detecting defects on the specimen based on at least two of the optical based output, the electron beam based output, results of the one or more functions, and results of the one or more simulations.

ALDEHYDE CONJUGATES AND USES THEREOF

The present invention provides compounds and methods of use thereof for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 213-. (canceled)14. The method according to claim 1 , wherein the biologically relevant aldehyde is selected from formaldehyde claim 1 , acetaldehyde claim 1 , acrolein claim 1 , glyoxal claim 1 , methylglyoxal claim 1 , hexadecanal claim 1 , octadecanal claim 1 , hexadecenal claim 1 , succinic semi-aldehyde claim 1 , malondialdehyde claim 1 , 4-hydroxynonenal claim 1 , 4-hydroxy-2E-hexenal claim 1 , 4-hydroxy-2E claim 1 ,6Z-dodecadienal claim 1 , and leukotriene B4 aldehyde.1517-. (canceled)2023-. (canceled)24. The method of claim 1 , wherein the method treats an ocular disorder in a patient.25. (canceled)26. The method of claim 24 , wherein the ocular disorder is selected from the group consisting of dry eye syndrome claim 24 , cataracts claim 24 , keratoconus claim 24 , bullous and other keratopathy claim 24 , Fuch's endothelial dystrophy claim 24 , allergic conjunctivitis claim 24 , ocular cicatricial pemphigoid claim 24 , conditions associated with PRK healing and other corneal healing claim 24 , conditions associated with tear lipid degradation or lacrimal gland dysfunction claim 24 , uveitis claim 24 , scleritis claim 24 , ocular Stevens Johnson Syndrome claim 24 , and ocular rosacea.27. The method of claim 26 , wherein the ocular disorder is dry eye syndrome.28. The method of claim 26 , wherein the ocular disorder is a condition associated with PRK healing and other corneal healing.29. The method of claim 26 , wherein the ocular disorder is selected from the group consisting of ...

Targeting chelants and chelates

Novel chelants and other compounds, and compositions thereof are provided, that are useful for detection and treatment of cancer and other abnormal and disease-state cells and tissues.

Geared bicycle wheel display disk

The present invention describes a internally geared display bicycle wheel covers that rotate upon a gear cluster in relation to the rotation of the bicycle wheel. The invention consists of twin disk assemblies mounted to both sides of a conventional bicycle wheel and inturn to the front and rear of a bicycle frame. The disk assemblies are manufactured of lightweight inexpensive material that is formed to the convex shape of the outer surface of a bicycle wheel and includes an internal gear mechanism made of a high density, self lubricating plastic. Gear ratios may be changed to achieve a desired rotation of the outer display disk or geared as such to hold the disk in an upright position at all times whether the bicycle is in motion or in repose.

Solar Metrology Methods And Apparatus

Methods and apparatus are presented to measure the photoluminescence of incoming wafers and extract parameters such as minority carrier life time, diffusion length, and defect density that may be used to predict final solar cell efficiency. In some examples, illumination light is supplied to a side of an as-cut silicon wafer and the induced luminescence measured from the same side and the opposite side of the wafer is used to determine an indication of the minority carrier lifetime. In another example, the luminescence induced by two instances of illumination light of different wavelength is used to determine an indication of the minority carrier lifetime. In another example, the spatial distribution of luminescence intensity over an area surrounding a focused illumination spot is used to determine an indication of the minority carrier lifetime. Other apparatus useful to passivate the surface of a wafer for inspection are also presented. 1. A method comprising:illuminating an amount of semiconductor material from at least one side with an amount of illumination light;receiving a first amount of light emitted from the amount of semiconductor material at the at least one side of the amount of semiconductor material;receiving a second amount of light emitted from the amount of semiconductor material at a side opposite the at least one side of the amount of semiconductor material; anddetermining an indication of a bulk carrier lifetime of the amount of semiconductor material based on the first amount of light and the second amount of light.2. The method of claim 1 , wherein the determining of the indication involves determining a difference between the first amount of light and the second amount of light.3. The method of claim 1 , wherein the determining of the indication involves determining a ratio between the first amount of light and the second amount of light.4. The method of claim 1 , wherein the illuminating involves illuminating a first side of the amount of ...

Flower box

Vacuum package system

A vacuum packaging system for transporting a plurality of medical containers includes a plurality of medical containers each having a head side and a base side and a tray that receives and supports the medical containers. The tray includes opposing first and second sidewalls, opposing front and rear walls and a bottom floor. The walls extend generally vertically from the floor of the tray. At least one platform generally extends parallel to the floor of the tray. An air impervious flexible film defines an internal cavity. The air impervious flexible film completely surrounds the tray and the medical containers and the internal cavity is evacuated to and maintained at a predetermined vacuum level below atmospheric pressure. One of the head side and the base side of each medical container contacts a top surface of at least one platform when the medical containers are positioned in the tray.

CONDUCTOR COVER APPLICATOR

Methods and applicators for applying tubular conductor cover to a cable. The applicator may retain a user's hand. The applicators may stop a user's hand from moving relative to the applicator in a direction opposed to a path of conductor cover passage through the applicator. An applicator for applying a tubular conductor cover to a cable, the conductor cover being split longitudinally to define a first longitudinal edge and a second longitudinal edge, the applicator comprising: a separator shaped to contact, in operation of the applicator, an interior surface of the conductor cover to spread open the first longitudinal edge and the second longitudinal edge along a portion of the conductor cover to allow the portion of the conductor cover to be applied to a cable; and a hand retainer connected to or forming part of the separator. A method of applying tubular conductor cover to a cable, the conductor cover being split longitudinally to define a first longitudinal edge and a second longitudinal edge, the method comprising: positioning a hand in a hand retainer connected to or forming part of a separator; spreading open the first longitudinal edge and the second longitudinal edge of a portion of the conductor cover with a separator, the separator contacting an interior surface of the conductor cover; and applying a length of conductor cover to the cable through the separator. 1. An applicator for applying a tubular conductor cover to a cable , the conductor cover being split longitudinally to define a first longitudinal edge and a second longitudinal edge , the applicator comprising:a separator shaped to contact, in operation of the applicator, an interior surface of the conductor cover to spread open the first longitudinal edge and the second longitudinal edge along a portion of the conductor cover to allow the portion of the conductor cover to be applied to a cable; anda hand retainer connected to or forming part of the separator.2. The applicator of in which the hand ...

VACUUM PACKAGE SYSTEM

A vacuum packaging system for transporting a plurality of medical containers includes a plurality of medical containers each having a head side and a base side and a tray that receives and supports the medical containers. The tray includes opposing first and second sidewalls, opposing front and rear walls and a bottom floor. The walls extend generally vertically from the floor of the tray. At least one platform generally extends parallel to the floor of the tray. An air impervious flexible film defines an internal cavity. The air impervious flexible film completely surrounds the tray and the medical containers and the internal cavity is evacuated to and maintained at a predetermined vacuum level below atmospheric pressure. One of the head side and the base side of each medical container contacts a top surface of at least one platform when the medical containers are positioned in the tray.

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 142-. (canceled)44. The method of claim 43 , wherein p is 1.45. The method of claim 43 , wherein each Qis methyl.46. The method of claim 43 , wherein Ris a halogen.47. The method of claim 46 , wherein the halogen is chlorine or fluorine.48. The method of claim 47 , wherein the halogen is chlorine.49. The method of claim 43 , wherein the compound is present at a concentration from about 0.05-10% w/v.50. The method of claim 43 , wherein the compound is present at a concentration from about 0.1-5% w/v.51. The method of claim 43 , wherein the compound is present at a concentration from about 0.1-2% w/v.52. The method of claim 43 , wherein the compound is present at a concentration from about 0.1-1.0% w/v.53. The method of claim 43 , wherein the compound is present at a concentration from about 0.09-0.5% w/v.54. The method of claim 43 , wherein the compound present in an admixture with a cyclodextrin.55. The method of claim 54 , wherein the cyclodextrin comprises a β-cyclodextrin or a pharmaceutically acceptable salt thereof.56. The method of claim 55 , wherein the β-cyclodextrin is selected from the group consisting of sulfobutylether-β-cyclodextrin claim 55 , 2-hydroxypropyl-β-cyclodextrin claim 55 , and 3-hydroxypropyl-β-cyclodextrin.57. The method of claim 56 , wherein the β-cyclodextrin is sulfobutylether-β-cyclodextrin or a pharmaceutically acceptable salt thereof.58. The method of claim 57 , wherein the salt of sulfobutylether-β-cyclodextrin is sulfobutylether-β-cyclodextrin sodium salt.59. The method of claim 58 , wherein ...

ALDEHYDE CONJUGATES AND USES THEREOF

The present invention provides compounds and methods of use thereof for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 3. The method according to claim 2 , wherein W claim 2 , X claim 2 , Y claim 2 , and Z are CH.4. The method according to claim 3 , wherein k is 2.5. The method according to claim 4 , wherein the two occurrences of U on adjacent carbon atoms form a fused phenyl ring claim 4 , optionally substituted with chlorine.12. A composition comprising a compound of formula A according to any one of - and a pharmaceutically acceptable adjuvant claim 4 , carrier claim 4 , or vehicle.13. The composition according to claim 12 , in combination with an additional therapeutic agent.14. The method according to any one of - claim 12 , wherein the biologically relevant aldehyde is selected from formaldehyde claim 12 , acetaldehyde claim 12 , acrolein claim 12 , glyoxal claim 12 , methylglyoxal claim 12 , hexadecanal claim 12 , octadecanal claim 12 , hexadecenal claim 12 , succinic semi-aldehyde claim 12 , malondialdehyde claim 12 , 4-hydroxynonenal claim 12 , and retinaldehyde.15. The method according to claim 14 , wherein the biologically relevant aldehyde is succinic semi-aldehyde.18. A conjugate provided according to the method of .21. A method of treating a disease in a patient in need comprising the method according to .22. A method of treating claim 21 , preventing claim 21 , or reducing a risk of a disease claim 21 , disorder claim 21 , condition claim 21 , or cosmetic indication in which aldehyde toxicity is implicated in a subject in need thereof claim 21 , comprising the method according to .23. The ...

Apparatus for positioning a breast for radiation treatment

The present invention provides a method and apparatus to decrease acute and late skin toxicity for breast cancer patients undergoing radiation therapy. This invention will enable better breast positioning during therapy, eliminating skin folds and reducing the skin dose below that required for development of moist desquamation. The present invention has the potential to reduce the volume of normal tissue and organs at risk of being irradiated during a course of whole breast radiation therapy.

Combination treatment of ocular inflammatory disorders and diseases

The present disclosure provides a combination of a fused bicyclic amine compound and an anti-inflammatory agent for treating ocular inflammatory disorders and diseases. Further provided are pharmaceutical compositions of the compound and the anti-inflammatory agent.

Method and system for hierarchical tissue analysis and classification

The present invention may include segmenting an image at a first resolution level and a second resolution level, wherein one or more parameters of a segmentation algorithm are trainable via user classification feedback, extracting features from a first plurality of segment primitives and a second plurality of segment primitives, wherein one or more parameters of a segment feature extraction algorithm are trainable via user classification feedback, building a first and second segmentation hierarchy by generating one or more clusters of the first plurality of segment primitives and the second plurality of segment primitives, extracting one or more features from the first segmentation hierarchy and the second segmentation hierarchy utilizing a hierarchy feature extraction algorithm, determining an inter-level relationship between the clusters generated for the first resolution level and the second level, and automatically classifying one or more tissue elements of the tissue specimen via a ...

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 142-. (canceled)44. The method of claim 43 , wherein p is 1.45. The method of claim 43 , wherein each Qis methyl.46. The method of claim 43 , wherein Ris a halogen.47. The method of claim 46 , wherein the halogen is chlorine or fluorine.48. The method of claim 47 , wherein the halogen is chlorine.49. The method of claim 43 , wherein the compound is present at a concentration from about 0.05 to about 10% w/v.50. The method of claim 43 , wherein the compound is present at a concentration from about 1 to about 10% w/v.51. The method of claim 43 , wherein the compound is present at a concentration from about 0.1 to about 5% w/v.52. The method of claim 43 , wherein the compound is present at a concentration from about 0.1 to about 2% w/v.53. The method of claim 43 , wherein the compound is present at a concentration from about 0.1 to about 1.0% w/v.54. The method of claim 43 , wherein the compound is present at a concentration from about 0.05 to about 1.5% w/v.55. The method of claim 43 , wherein the compound is present at a concentration from about 1 to about 5% w/v.56. The method of claim 43 , wherein the compound is present at a concentration from about 1 to about 1.5% w/v.57. The method of claim 43 , wherein the compound is present at a concentration from about 1 to about 2.0% w/v.58. The method of claim 43 , wherein the compound is present at a concentration of about 1% w/v.59. The method of claim 43 , wherein for the compound of formula (I):{'sub': 'a', 'each Qis methyl;'}{'sub': 'B', 'Ris halogen; and'}p is 1.60. The method ...

Alignment correction prior to image sampling in inspection systems

A method and apparatus, and variations of each, for inspecting a wafer defining at least one die thereon is disclosed. The present invention first obtains the electronic image equivalent of two die, and then determines the x and y offset between those electronic images. Prior to inspection for defects, those two electronic images are aligned by adjusting the x and y positions of one electronic image of one die with respect to the electronic image of the other die. Once that is accomplished, the those electronic images are compared to detect any defects that may exist on one of the die.

Apparatus for use in unpacking shipping containers

An apparatus (600) for use in unpacking or packing shipping containers (700) includes at least one barrier part which provides a barrier to wheeled powered material handling equipment (1105). The barrier part can be positioned substantially transversely across an interior of a shipping container (700) at a desired position along the length of the interior of the shipping container, to provide a working area (1120) within the shipping container in which personnel may work on foot, and substantially impede or prevent entry of wheeled powered material handling equipment into the working area. The apparatus may be provided with an arrangement to substantially maintain its location in the desired position against forces resulting from impact by the powered material handling equipment operating within the shipping container.

Dark field inspection system with ring illumination

A dark field inspection system that minimizes the speckle noise due to sample surface roughness can include a plurality of beam shaping paths for generating a composite, focused illumination line on a wafer. Each beam shaping path can illuminate the wafer at an oblique angle. The plurality of beam shaping paths can form a ring illumination. This ring illumination can reduce the speckle effect, thereby improving SNR. An objective lens can capture scattered light from the wafer and an imaging sensor can receive an output of the objective lens. Because the wafer illumination occurs at oblique angles, the objective lens can have a high NA, thereby improving optical resolution of the imaging sensor, and the resulting signal level.

Confocal wafer inspection method and apparatus using fly lens arrangement

A semiconductor wafer inspection system and method is provided which uses a multiple element arrangement, such as an offset fly lens array. The preferred embodiment uses a laser to transmit light energy toward a beam expander, which expands the light energy to create an illumination field. An offset fly lens array converts light energy from the illumination field into an offset pattern of illumination spots. A lensing arrangement, including a first lens, a transmitter/reflector, an objective, and a Mag tube imparts light energy onto the specimen and passes the light energy toward a pinhole mask. The pinhole mask is mechanically aligned with the offset fly lens array. Light energy passing through each pinhole in the pinhole mask is directed toward a relay lens, which guides light energy onto a sensor. The offset fly lens array corresponds to the pinhole mask. The offset pattern of the offset fly lens array is chosen such that spots produced can be recombined into a continuous image, and ...

ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF

The present invention provides compounds and methods for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 120-. (canceled)2244-. (canceled)45. The method of claim 21 , comprising administering to the subject an effective amount of compound I-1.46. The method of claim 21 , comprising administering to the subject an effective amount of a pharmaceutically acceptable salt of I-1.47. The method of claim 21 , wherein the method treats developmental delay claim 21 , hypotonia claim 21 , severe expressive language impairment claim 21 , obsessive-compulsive disorder claim 21 , epilepsy claim 21 , ADHD claim 21 , or aggression associated with SSADHD.48. The method of claim 21 , wherein the method reduces accumulation of GABA in the subject caused by SSADHD.49. The method of claim 21 , wherein the method reduces accumulation of gamma-hydroxybutyrate (GHB) in the subject caused by SSADHD.50. The method of claim 21 , wherein the method reduces accumulation of GABA and GHB in the subject caused by SSADHD.51. The method of claim 21 , wherein the subject is a human.52. The method of claim 50 , wherein the subject is a human.54. The method of claim 53 , wherein the method comprises contacting brain slices of B6.129-Aldh5a1/J (SSADH null) mice with compound I-1 or a pharmaceutically acceptable salt thereof. This application claims the benefit of U.S. Provisional Application No. 62/378,065, filed on Aug. 22, 2016, the entirety of which is hereby incorporated by reference.Metabolic and inflammatory processes in cells generate toxic aldehydes, such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE or 4-HNE). These aldehydes ...

Toxic aldehyde related diseases and treatment

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

SYSTEMS AND METHODS OF SPLIT BILLING

A method includes generating a request at an electronic device associated with a plurality of data usage accounts. The method also includes selectively encapsulating, by the electronic device, the request to generate an encapsulated request that identifies a destination endpoint provisioned for a first data usage account of the plurality of data usage accounts. The method further includes transmitting the encapsulated request from the electronic device to a network element. 1. A method comprising:receiving user input during execution of a first application at an electronic device, the user input corresponding to a selection of a first data usage account of a plurality of data usage accounts associated with the electronic device and the user input indicating that data usage of the electronic device is to be billed to the first data usage account;generating a request during execution of a second application at the electronic device;based on the selection of the first data usage account, encapsulating, by the electronic device, the request to generate an encapsulated request that identifies a destination endpoint provisioned for the first data usage account; andtransmitting the encapsulated request from the electronic device to a network element.2. The method of claim 1 , wherein the destination endpoint comprises a voice call endpoint.3. The method of claim 1 , wherein the destination endpoint comprises a virtual private networking endpoint or a business endpoint.4. The method of claim 1 , wherein the destination endpoint comprises a service platform.5. The method of claim 4 , wherein the service platform hosts a proxy.6. The method of claim 5 , wherein the proxy comprises a socket secure proxy.7. (canceled)8. The method of claim 1 , wherein the plurality of data usage accounts comprises an enterprise account and a personal account.9. (canceled)10. The method of claim 1 , wherein the first application comprises a workspace application that enables switching between ...

Alignment correction prior to image sampling in inspection systems

A method and apparatus, and variations of each, for inspecting a wafer defining at least one die thereon is disclosed. The present invention first obtains the electronic image equivalent of two die, and then determines the x and y offset between those electronic images. Prior to inspection for defects, those two electronic images are aligned by adjusting the x and y positions of one electronic image of one die with respect to the electronic image of the other die. Once that is accomplished, the those electronic images are compared to detect any defects that may exist on one of the die.

COMBINATION TREATMENT OF OCULAR INFLAMMATORY DISORDERS AND DISEASES

The present disclosure provides a combination of a fused bicyclic amine compound and an anti-inflammatory agent for treating ocular inflammatory disorders and diseases. Further provided are pharmaceutical compositions of the compound and the anti-inflammatory agent.

Acyl-ACP thioesterase nucleic acids from maize and methods of altering palmitic acid levels in transgenic plants therewith

Genes encoding maize oleoyl-ACP and palmitoyl-ACP thioesterase enzymes have been isolated from maize. These genes, when expressed in a plant, can be used to create transgenic plants having altered palmitic acid oil profiles.

BARRIER WALLS AND METHODS OF USE IN ELECTRICAL POWER TRANSMISSION SYSTEMS

A method of protecting an exposed switch mounted on a structural frame in an electrical power transmission system, the switch having one or more insulators extended from the structural frame, first and second conductor connectors supported on the one or more insulators, and a blade connected to pivot to close and open an electrical path between the first and second conductor connectors, the method including mounting a barrier wall adjacent the switch and on the structural frame. 1. A method of protecting a switch having exposed conducting components and being mounted on a structural frame that forms part of an electrical power transmission system , the switch having one or more insulators extended from the structural frame , first and second conductor connectors supported on the one or more insulators , and a blade connected to pivot to close and open an electrical path between the first and second conductor connectors , the method comprising mounting a barrier wall adjacent the switch and on the structural frame.2. The method of in which the barrier wall is spaced from the switch when mounted.3. The method of in which the switch is a knife blade switch and the blade comprises one or more throw arms.4. The method of in which the switch has lateral sides defined as being extended from the structural frame and between the first and second conductor connectors claim 1 , in which the barrier wall is positioned along one of the lateral sides when mounted.5. The method of in which the switch has two or more insulators whose respective axes define a plane extended from the structural frame claim 1 , in which the barrier wall is mounted parallel to the plane.6. The method of in which the blade is connected to pivot in a lever plane claim 1 , and in which the barrier wall is mounted parallel to the lever plane.7. The method of in which the barrier wall has a plurality of wind apertures.8. The method of in which the barrier wall is mounted to the structural frame using one or ...

Method of selecting operation in a line-powered module

A line-powered module that is selectively operable in one of a plurality of modes of operation based upon the value of a selection signal. The line-powered module includes a control unit that selectively operates the module in one of the plurality of modes of operation based upon the value of a selection signal received by the control unit. The line-powered module includes a selection input that is coupled to the control unit such that the selection signal can be received at the selection input. Preferably, the selection input receives a selection wire that can be moved between different points of connection to define the plurality of states of the selection signal. Based upon the connection of the selection wire, the control unit operates the line-powered module in one of the plurality of modes of operation.

Medical container

The present invention relates to a medical container useful upon transportation of plural syringe barrels. The medical container includes at least a container main body and a holding member arranged inside the container main body. The holding member is provided at least with a plurality of cylindrical holding portions for holding syringe barrels. The container main body has at least a peripheral rim arranged on and along an outer periphery of an opening and a shoulder-shaped portion arranged on an inner wall of the container to arrange the holding member. The shoulder-shaped portion has at least three ribs for supporting the holding member, and has a structure that enables to arrange via the ribs the holding member in a horizontal position relative to a bottom wall of the container main body. According to the present invention, there is provided a medical container of a construction that can be promptly brought into a sterilized state by various methods, can be readily brought into a state ...

Multifunctional relay module for use with CO and smoke alarms

A multi-function relay module for use with a series of hazardous condition detectors that are interconnected by an interconnect line. The relay module is positioned between the interconnected hazardous condition detectors and one or more auxiliary devices such that the relay module can selectively activate each of the auxiliary devices. The relay module receives the interconnect signal and determines whether the interconnect signal is indicating a first sensed condition or a second sensed condition. A selection signal having multiple states is received by the control unit. The control unit is programmed to respond to the type of sensed condition indicated by the interconnect signal based upon the state of the selection signal. Thus, the relay module can selectively respond to either the first sensed condition, the second sensed condition or either of the first or second sensed conditions.

Xenorhabdus TC proteins and genes for pest control

The subject inventions relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifcally, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus strain Xwi. The subject invention also provides an exochitinase obtainable from the Xwi strain. The exochitinase can be used to control insects using methods known in the art.

Bicycle advertising and garphic display medium

The present invention discloses a bicycle as an advertising and graphic display medium encompassing the frame and wheel disks as a whole. The bicycle and non-rotating wheel displays, front and back, traverse the landscape as one unit and while in a motionless state. The bicycle becomes a solid unit, frame and non-rotating display wheels become one surface.

Alignment correction prior to image sampling in inspection systems

A method and apparatus, and variations of each, for inspecting a wafer defining at least one die thereon is disclosed. The present invention first obtains the electronic image equivalent of two die, and then determines the x and y offset between those electronic images. Prior to inspection for defects, those two electronic images are aligned by adjusting the x and y positions of one electronic image of one die with respect to the electronic image of the other die. Once that is accomplished, the those electronic images are compared to detect any defects that may exist on one of the die.

Non-antibody ligands for detecting target proteins

The invention relates generally to synthetic non-antibody protein scaffolds (synNAPS) that differentially detect or quantitate a target insecticidal protein in a complex biological matrix comprising the target protein and a non-target insecticidal protein and to methods of using the synNAPS in immunoassays, and more particularly to monoclonal antibodies and immunoassays for the differential detection and quantitation of a wild-type crystal protein, such as a wild-type-Cry1Ab, from Bacillus thuringiensis and hybrid crystal proteins, which comprise all or a significant portion of the wild-type Cry protein in complex biological samples comprising both the wild-type Cry protein and one or more of the hybrid Cry proteins.

INORGANIC BINDERS FOR IMPROVED ANODES IN RECHARGEABLE ALKALI METAL ION BATTERIES

Inorganic binders comprising silicon or phosphorus have been discovered that offer advantages for use in rechargeable alkali metal ion battery anodes. These improved anodes are less hydrophilic and not subject to the deformation that can occur in conventional anodes from water absorption even at dry room levels. However, the performance characteristics in batteries is comparable to or even better than that obtained from conventional anodes. Also advantageously, these anodes can be prepared from aqueous slurries.

Systems and methods of split billing

A method includes generating a request at an electronic device associated with a plurality of data usage accounts. The method also includes selectively encapsulating, by the electronic device, the request to generate an encapsulated request that identifies a destination endpoint provisioned for a first data usage account of the plurality of data usage accounts. The method further includes transmitting the encapsulated request from the electronic device to a network element.

Dark Field Inspection System With Ring Illumination

A dark field inspection system that minimizes the speckle noise due to sample surface roughness can include a plurality of beam shaping paths for generating a composite, focused illumination line on a wafer. Each beam shaping path can illuminate the wafer at an oblique angle. The plurality of beam shaping paths can form a ring illumination. This ring illumination can reduce the speckle effect, thereby improving SNR. An objective lens can capture scattered light from the wafer and an imaging sensor can receive an output of the objective lens. Because the wafer illumination occurs at oblique angles, the objective lens can have a high NA, thereby improving optical resolution of the imaging sensor, and the resulting signal level.

Toxic aldehyde related diseases and treatment

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Toxic aldehyde related diseases and treatment

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Non-rotating bicycle wheel display disk

The present invention describes a non-rotating display bicycle wheel cover assembly that remains absolutely upright in relation to the rotation of the bicycle wheel and in relation to a parked bicycle wheel. The invention consists of twin disk assemblies mounted to both sides of a conventional bicycle wheel and inturn to the front and rear of a bicycle frame. The disk assemblies are manufactured of lightweight inexpensive material that is formed to the convex shape of the outer surface of a bicycle wheel and includes an overmolded, captive friction bearing made of a high density, self lubricating plastic. A plastic retaining mechanism is secured to the outer disk fascia and a bicycle frame member to hold the disk in an upright position at all times whether the bicycle is in motion or in repose.

Treatment of allergic eye conditions with cyclodextrins

The present disclosure provides methods of treating eye allergies and allergic conjunctivitis with cyclodextrin. Ophthalmic compositions of cyclodextrin for topical administration are also provided.

Inspection site preparation

Embodiments of the present disclosure are directed to an electron beam imaging/inspection apparatus having an electron source device to direct flood electrons on a sample immediately before image acquisition or inspection. The apparatus comprises a first device configured to charge a sample in a first mode, wherein the first device includes an electron source configured to provide a flood beam of charged particles to a first area of the sample. The apparatus also comprises a second device configured to generate a primary beam of electrons and characterize an interaction between the primary beam and a second area of the sample within the first area in a second mode. The apparatus is configured to switch from the first mode to the second mode less than 1 second.

TREATMENT OF ALLERGIC EYE CONDITIONS WITH CYCLODEXTRINS

The present disclosure provides methods of treating eye allergies and allergic conjunctivitis with cyclodextrin. Ophthalmic compositions of cyclodextrin for topical administration are also provided.

Toxic aldehyde related diseases and treatment

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Method of using barrier walls in electrical power transmission systems

A method of protecting an exposed switch mounted on a structural frame in an electrical power transmission system, the switch having one or more insulators extended from the structural frame, first and second conductor connectors supported on the one or more insulators, and a blade connected to pivot to close and open an electrical path between the first and second conductor connectors, the method including mounting a barrier wall adjacent the switch and on the structural frame.

Systems and Methods of Split Billing

A method includes receiving input during execution of a first application at an electronic device. The input indicates that data usage of the electronic device is to be billed to a first data usage account of a plurality of data usage accounts associated with the electronic device. The method further includes generating a request during execution of a second application at the electronic device. The method also includes, based on the input, encapsulating, by the electronic device, the request to generate an encapsulated request that identifies a destination endpoint provisioned for the first data usage account. The method further includes transmitting the encapsulated request from the electronic device to a network element. 1. A method comprising:receiving input during execution of a first application at an electronic device, the input indicating that data usage of the electronic device is to be billed to a first data usage account of a plurality of data usage accounts associated with the electronic device;generating a request during execution of a second application at the electronic device;based on the input, encapsulating, by the electronic device, the request to generate an encapsulated request that identifies a destination endpoint provisioned for the first data usage account; andtransmitting the encapsulated request from the electronic device to a network element.2. The method of claim 1 , wherein the first data usage account is associated with a telephone number claim 1 , and wherein a second data usage account of the plurality of data usage accounts is associated with a pseudo-telephone number.3. The method of claim 1 , wherein the network element comprises a server that corresponds to the destination endpoint.4. The method of claim 1 , wherein the input corresponds to a selection of the first data usage account of the plurality of data usage accounts claim 1 , and wherein the destination endpoint comprises a voice call endpoint.5. The method of claim 1 , ...

Conductor cover applicator

Methods and applicators for applying tubular conductor cover to a cable. The applicator may retain a user's hand. The applicators may stop a user's hand from moving relative to the applicator in a direction opposed to a path of conductor cover passage through the applicator. An applicator for applying a tubular conductor cover to a cable, the conductor cover being split longitudinally to define a first longitudinal edge and a second longitudinal edge, the applicator comprising: a separator shaped to contact, in operation of the applicator, an interior surface of the conductor cover to spread open the first longitudinal edge and the second longitudinal edge along a portion of the conductor cover to allow the portion of the conductor cover to be applied to a cable; and a hand retainer connected to or forming part of the separator. A method of applying tubular conductor cover to a cable, the conductor cover being split longitudinally to define a first longitudinal edge and a second longitudinal ...

SYSTEM AND METHOD FOR ADJUSTING ROLLER CONE PROFILE ON HYBRID BIT

An earth boring drill bit designed for a specific performance, within a finished product tolerance, using components built to a looser manufacturing tolerance. The bit may be assembled by selecting a leg from a plurality of pre-manufactured legs; selecting a bit body from a plurality of pre-manufactured bit bodies, the bit body having a slot for receiving the leg; placing the leg within the slot; and fixing the leg within the slot within the finished product tolerance by placing one or more shims between the leg and the slot. The shims may be used to adjust an axial position, a radial position, and/or a circumferential position of the leg with respect to the slot. The leg and the bit body may be selected, or produced, to ensure the bit will not meet the specification, given the manufacturing tolerance, without the shims. 1. A method of assembling an earth boring drill bit to meet a finished product tolerance relative to a desired aggressiveness of the finished bit using components built to a manufacturing tolerance that , the method comprising the steps of:selecting one or more legs from a plurality of pre-manufactured legs;selecting a bit body from a plurality of pre-manufactured bit bodies, the bit body having a slot for receiving the leg the slot having an axial wall, a radial wall, and at least one circumferential wall;placing the leg within the slot; andfixing the leg within the slot to meet the desired aggressiveness within the finished product tolerance by placing one or more shims between the leg and at least one of the walls of the slot.2. The method of claim 1 , further including the step of welding the leg and shims into the bit body.3. The method of claim 1 , further including the step of bolting the leg and shims into the bit body.4. The method of claim 1 , further including the step of selecting a number of shims to bring the earth boring drill bit within the finished product tolerance.5. The method of claim 1 , further including the step of selecting ...

METHODS OF REDUCING ABSORPTION OF TRANS FATTY ACIDS USING WATER-INSOLUBLE CELLULOSE DERIVATIVES

Provided are food products comprising at least 0.5 g of trans fatty acid per serving and one or more water-insoluble cellulose derivatives in an amount sufficient to reduce absorption of the trans fatty acid by a mammal consuming the food product, methods of ameliorating the harmful effects of trans fatty acids on a mammal that has consumed trans fatty acids, and methods of reducing the amount of trans fatty acids capable of being absorbed by a mammal ingesting a trans fatty acid containing food product. 1. A food product comprising:at least 0.5 g of trans fatty acid per serving; andone or more water-insoluble cellulose derivatives in an amount sufficient to reduce absorption of the trans fatty acid by a mammal consuming the food product.2. The food product of claim 1 , wherein the water-insoluble cellulose derivative is ethyl cellulose.3. The food product of claim 1 , wherein the water-insoluble cellulose derivative is present from 2 to 10 weight percent claim 1 , more preferably from 2 to 6 weight percent claim 1 , based on the total weight of the food product.4. The food product of claim 1 , wherein the food product is prepared with partially hydrogenated vegetable oil.5. A method of ameliorating the harmful effects of trans fatty acids on a mammal that has consumed trans fatty acids claim 1 , comprising:administering one or more water-insoluble cellulose derivatives to the mammal.6. The method of claim 5 , wherein the water-insoluble cellulose derivative is ethyl cellulose.7. The method of claim 5 , wherein the mammal is a human claim 5 , and the water-insoluble cellulose derivative is administered in an amount from about 2 to 30 g claim 5 , more preferably about 3 to 25 g.8. A method of reducing the amount of trans fatty acids capable of being absorbed by a mammal ingesting a trans fatty acid containing food product claim 5 , comprising the steps of:incorporating one or more water-insoluble cellulose derivatives in the food product; oradministering one or more ...

SMS-INITIATED MOBILE REGISTRATION

Embodiments are directed towards SMS-initiated mobile registration. A mobile device sends an SMS message to a mobile registration device. In response, the mobile registration device generates a random identifier and associates it with the mobile device identifier of the mobile device. Then, the mobile registration device sends a response SMS message to the mobile device, the response SMS message containing a Uniform Resource Identifier (URI) to a mobile registration web page, where the URI contains the generated random identifier. The mobile device uses the URI to navigate to the mobile registration web page, where additional registration information is provided. The mobile registration device associates the additional registration information with the mobile device based on the generated random identifier included in the URI, and creates a user account based on the mobile number from which the SMS message was received and the additional registration information. 1. A computer based method , comprising:receiving a request Short Message Service (SMS) message from a mobile device;generating a token and associating the token with a mobile device identifier of the mobile device;transmitting a response SMS message to the mobile device, the response SMS message including a Uniform Resource Identifier (URI) to a registration web page, wherein the URI includes the generated token;receiving registration information submitted to the registration web page and the token included in the URI of the registration web page;associating the submitted registration information and the mobile device identifier based on the token; andcreating an online account based on the registration information and the associated mobile device identifier.2. The computer based method of claim 1 , further comprising:expiring the generated token after a defined amount of time,3. The computer based method of claim 1 , wherein the request SMS message further includes a subset of the registration information ...

Game transaction module interface to single port printer

A gaming device includes a game module for presenting instances of a game title and a game transaction module for interfacing with a system controller of a game entertainment center. The gaming device further includes a printer for printing various items such as tickets, coupons, vouchers, and other promotional material. The gaming device further includes a printer manager for arbitrating print job conflicts.

Partial Credits Cashout Gaming Unit

A system or method providing a player to cashout half of credits accumulated during gaming. Anonymous cashing out of credit is available to a player through routes both external and internal to a gaming machine. 1. In a gaming system including a slot data system and a gaming monitoring unit or gaming transaction manager coupled to the slot data system , an electronic gaming unit providing partial cashout , comprising: receiving a partial cashout request from a player of the electronic gaming unit; and', 'requesting data representing a partial cashout corresponding to the partial cashout request from the gaming monitoring unit or gaming transaction manager; and, 'a gaming processor, comprising circuitry fora ticket printer for printing a ticket reflecting the partial cashout representative data before notification of the slot data system.2. The gaming unit of claim 1 , wherein the gaming processor further comprises circuitry for:presenting one or more partial cashout offer amounts; andreceiving a player choice from among the partial cashout offer amounts.3. The gaming unit of claim 1 , wherein the gaming processor circuitry requests partial cashout representative data including possible cashout amounts.4. The gaming unit of claim 1 , wherein the gaming processor determines possible cashout amounts.5. The gaming unit of claim 1 , wherein the gaming processor requests partial cashout representative data including data representing bar codes for tickets.6. The gaming unit of claim 1 , wherein the electronic gaming unit circuitry sends data confirming printing of tickets to the gaming monitoring unit or gaming transaction manager.7. The gaming unit of claim 1 , wherein the electronic gaming unit circuitry presents a partial credit cashout touch screen button to the player.8. The gaming unit of claim 1 , wherein the electronic gaming unit circuitry provides for anonymous cashout.9. In a gaming system including a slot data system and a gaming monitoring unit or gaming ...

QUANTIFICATION AND CHARACTERIZATION OF ALLERGENS

Embodiments of the invention include methods of determining the allergen content of a composition. Embodiments of the invention may include providing a composition comprising an allergen; at least partially purifying the allergen from the composition to form an extract; and determining the amount of allergen in the extract using liquid chromatography with ultraviolet and mass spectrometric detection. 1. A method of determining the allergen content of a composition , the method comprising:providing a composition comprising an allergen;at least partially purifying the allergen from the composition to form an extract; anddetermining the amount of allergen in the extract using liquid chromatography with ultraviolet and/or mass spectrometric detection.2. The method according to claim 1 , wherein the liquid chromatography is two-dimensional liquid chromatography.3. The method according to claim 1 , wherein the allergen is a food allergen claim 1 , latex allergen claim 1 , and/or an aero-allergen.4. The method according to claim 3 , wherein the food allergen is a food cereal crop claim 3 , peanut claim 3 , tree nut claim 3 , milk claim 3 , egg claim 3 , crustacean claim 3 , fish claim 3 , or potato allergen.5. The method according to claim 4 , wherein the food cereal crop allergen is maize lipid transfer protein.6. The method according to claim 3 , wherein the acro aero-allergen is a pollen or a spore.7. A method of determining the allergen content of a composition claim 3 , the method comprising:providing a composition comprising an allergen;at least partially purifying the allergen from the composition to form an extract;determining the amount of allergen in the extract using liquid chromatography with ultraviolet and/or mass spectrometric detection;providing a source of purified allergen; andcalibrating the equipment used to perform the liquid chromatography with ultraviolet and/or mass spectrometric detection with the source of purified allergen.8. The method according ...

Assessment and Correction of Transmitted Data

Methods and systems for improving the quality of transmitted data are described. Multiple distinct communication channels are used to transmit segments representing the same pre-transmission block of a data packet. Upon receipt of these segments, a system identifies differences between the segments for those segments that meet a quality threshold. The system selects one of segments for subsequent transmission or re-assembly into a data packet based on the prior performance of the communication channels used to transmit the segments. 1. A method for receiving data , comprising:receiving a first segment on a first communication channel, the first segment comprising a first data portion;receiving a second segment on a second communication channel, the second segment comprising a second data portion, the first and second data portions both corresponding to a same pre-transmission portion of a data packet;determining that the first and second data portions both meet a quality threshold, the quality threshold comprising an upper error limit with respect to the pre-transmission data portion; determining a first performance metric indicative of a first number of errors or a probability of error in segments previously received on the first communication channel;', 'determining a second performance metric indicative of a second number of errors or a probability of error in segments previously received on the second communication channel; and', 'responsive to the first performance metric indicating fewer errors than the second performance metric, selecting the first segment for continued processing., 'responsive to determining that the first data portion has at least one difference from the second data portion2. The method of claim 1 , wherein determining that the segments meet the quality threshold comprises:decoding a first error detection code (EDC) portion of the first segment to determine a number of errors in the first data portion;determining that the number of errors ...

APPARATUS AND METHODS FOR COMBINED BRIGHTFIELD, DARKFIELD, AND PHOTOTHERMAL INSPECTION

Disclosed are methods and apparatus for detecting defects or reviewing defects in a semiconductor sample. The system has a brightfield (BF) module for directing a BF illumination beam onto a sample and detecting an output beam reflected from the sample in response to the BF illumination beam. The system has a modulated optical reflectance (MOR) module for directing a pump and probe beam to the sample and detecting a MOR output beam from the probe spot in response to the pump beam and the probe beam. The system includes a processor for analyzing the BF output beam from a plurality of BF spots to detect defects on a surface or near the surface of the sample and analyzing the MOR output beam from a plurality of probe spots to detect defects that are below the surface of the sample. 1. A method of detecting defects or reviewing defects in a semiconductor sample , the method comprising:scanning a sample portion with a brightfield (BF) illumination beam;detecting a BF output beam reflected from the sample portion as the BF beam scans over the sample portion;determining surface or near-surface characteristics of the sample portion based on the detected BF output beam;finding candidate locations within the sample portion that are likely to have additional defects below a surface of the sample based on the determined surface or near-surface characteristics of the sample portion that were determined based on the detected BF output beam;directing a modulated pump beam and a probe beam at each candidate location;detecting a modulated optical reflectivity signal from each candidate location in response to each probe beam being directed to each candidate location; anddetermining a feature characteristic that is below the surface at each candidate location based on the modulated optical reflectivity signal detected from such candidate location.2. The method of claim 1 , further comprising:detecting a darkfield (DF) output beam scattered from the sample portion as the BF beam scans ...

CONNECTORS FOR USE IN SYSTEMS AND METHODS FOR REDUCING THE RISK OF PROXIMAL JUNCTIONAL KYPHOSIS

Systems and methods for reducing the risk of PJK, PJF, and other conditions are disclosed herein. In some embodiments, a longitudinal extension can be added to a primary fixation construct to extend the construct to one or more additional vertebral levels. The extension can be attached to a first attachment point, such as a spinous process of a vertebra that is superior to the primary construct. The extension can also be attached to a second attachment point, such as a component of the primary construct or an anatomical structure disposed inferior to the first attachment point. The extension can be more flexible than the primary construct and/or can limit motion to a lesser degree than the primary construct, thereby providing a more-gradual transition from the instrumented vertebrae to the natural patient anatomy adjacent thereto. The extension can be placed with little or no soft tissue disruption. 1. A surgical method comprising:attaching a primary construct to a spine of a patient, the primary construct extending between an uppermost instrumented vertebra (UIV) and a lowermost instrumented vertebra (LIV);attaching a connector to a first attachment point, the first attachment point comprising a spinous process disposed superior to the UIV of the primary construct;positioning the connector relative to the patient's spine; andattaching the connector to a second attachment point, the second attachment point being disposed at or inferior to the UIV of the primary construct.2. The method of claim 1 , wherein the first attachment point comprises a plurality of spinous processes disposed superior to the UIV of the primary construct.3. The method of claim 1 , wherein the second attachment point comprises first and second spinal rods of the primary construct.4. The method of claim 1 , wherein the second attachment point comprises first and second bone anchors of the primary construct.5. The method of claim 1 , wherein the connector includes a main body with first and ...

3D STRUCTURE INSPECTION OR METROLOGY USING DEEP LEARNING

Methods and systems for determining information for a specimen are provided. Certain embodiments relate to bump height 3D inspection and metrology using deep learning artificial intelligence. For example, one embodiment includes a deep learning (DL) model configured for predicting height of one or more 3D structures formed on a specimen based on one or more images of the specimen generated by an imaging subsystem. One or more computer systems are configured for determining information for the specimen based on the predicted height. Determining the information may include, for example, determining if any of the 3D structures are defective based on the predicted height. In another example, the information determined for the specimen may include an average height metric for the one or more 3D structures. 1. A system configured to determine information for a specimen , comprising:an imaging subsystem configured to generate images of a specimen, wherein one or more three-dimensional structures are formed on the specimen;one or more computer systems; andone or more components executed by the one or more computer systems, wherein the one or more components comprise a deep learning model configured for predicting a height of the one or more three-dimensional structures based on one or more of the images; andwherein the one or more computer systems are configured for determining information for the specimen based on the predicted height of the one or more three-dimensional structures.2. The system of claim 1 , wherein the one or more three-dimensional structures are one or more bumps formed on a wafer.3. The system of claim 1 , wherein determining the information comprises determining if any of the one or more three-dimensional structures are defective.4. The system of claim 1 , wherein the information comprises an average height metric for the one or more three-dimensional structures.5. The system of claim 1 , wherein the one or more of the images used for predicting the ...

Connectors for use in systems and methods for reducing the risk of proximal junctional kyphosis

Systems and methods for reducing the risk of PJK, PJF, and other conditions are disclosed herein. In some embodiments, a longitudinal extension can be added to a primary fixation construct to extend the construct to one or more additional vertebral levels. The extension can be attached to a first attachment point, such as a spinous process of a vertebra that is superior to the primary construct. The extension can also be attached to a second attachment point, such as a component of the primary construct or an anatomical structure disposed inferior to the first attachment point. The extension can be more flexible than the primary construct and/or can limit motion to a lesser degree than the primary construct, thereby providing a more-gradual transition from the instrumented vertebrae to the natural patient anatomy adjacent thereto. The extension can be placed with little or no soft tissue disruption.

A SPINAL FIXATION SYSTEM

A spinal fixation system, the system including: an alignment assembly comprising: a fastening element; and a mating element configured to receiving the fastening element thereover and having a releasable connector, a fixation assembly comprising: a plate having an aligning aperture that allows the mating element to be received therethrough; and an implant configured to be received between adjacent vertebrae and releasably connect with the releasable connector, wherein the fastening element is configured to move along the mating element to engage with the plate. 120-. (canceled)21. A spinal fixation system comprising: a fastening element having a long axis and a plate engagement portion comprising opposed wing portions converging towards said axis; and', 'a mating element configured to receive the fastening element thereover and having a releasable connector; and, 'an alignment assembly comprising a plate formed with an aligning aperture for receiving the mating element therethrough; and', 'an implant configured to be received between adjacent vertebrae and releasably connect with the releasable connector,, 'a fixation assembly comprisingwherein the fastening element is configured to move along the mating element to engage with the plate; andwherein during use the opposed wing portions contact one or more edges of the aligning aperture thereby bringing the plate into alignment with the fastening element.22. The spinal fixation system of claim 21 , wherein the fastening element includes an upper body having a driver engagement portion.23. The spinal fixation system of claim 21 , wherein the fastening element includes a lower body having the plate engagement portion.24. The spinal fixation system of claim 21 , wherein said wing portions comprise respective plate engaging surfaces such that claim 21 , in response to one of said wing portions engaging with at least one of a front and a rear wall forming said edges of the aligning aperture in the plate claim 21 , the ...

LOG ROLL

A training and exercise device is provided to aid in proper positioning, technique, and muscle memory for different sports and exercise related activities. The training device includes a cylindrical barrel member. A sled or sleds are connected to the barrel member such that rotation and movement of the barrel member will in turn move the sled or sleds. The sleds are bi-directional such that they are able to move in both forward and rear directions, which will allow the training device to be used in multiple directions without having to reorient the entire device between exercises. The barrel device, sled or sleds may also be configured to adjust the weights thereof to increase or decrease the resistance of the movement of the training device to accommodate for different user's size, abilities, and intended outcome. 1. A training device , comprising:a cylindrical member; andat least one sled operatively attached to the cylindrical member;wherein the at least one sled is moved in a direction relative to the direction of rotation of the cylindrical member.2. The training device of wherein the at least one sled comprises separate first and second sled members operatively connected to opposite ends of the cylindrical member.3. The training device of wherein the first and second sled members capable of sliding and including an upper member extending from the front to the rear of the sled members.4. The training device of further comprising an axle extending through the cylindrical member such that portions of the axle extend outside the cylindrical member claim 3 , wherein the axle capable of rotating independent of the cylindrical member.5. The training device of further comprising first and second bearing members positioned at the opposite ends of the cylindrical member claim 4 , with the axle extending through the first and second bearing members.6. The training device of further comprising first and second connecting members extending between the first and second ...

Method and System for Focus Adjustment of a Multi-Beam Scanning Electron Microscopy System

A scanning electron microscopy system is disclosed. The system includes a multi-beam scanning electron microscopy (SEM) sub-system. The SEM sub-system includes a multi-beam electron source configured to form a plurality of electron beams, a sample stage configured to secure a sample, an electron-optical assembly to direct the electron beams onto a portion of the sample, and a detector assembly configured to simultaneously acquire multiple images of the surface of the sample. The system includes a controller configured to receive the images from the detector assembly, identify a best focus image of images by analyzing one or more image quality parameters of the images, and direct the multi-lens array to adjust a focus of one or more electron beams based on a focus of an electron beam corresponding with the identified best focus image. 1. A multi-beam scanning electron microscopy apparatus comprising: a multi-beam electron source configured to form a plurality of electron beams;', 'a sample stage configured to secure a sample;', 'an electron-optical assembly including a set of electron-optical elements configured to direct at least a portion of the plurality of electron beams onto a portion of the sample; and', 'a detector assembly configured to simultaneously acquire a plurality of images of the surface of the sample, each image associated with an electron beam of the plurality of electron beams;, 'a multi-beam scanning electron microscopy sub-system comprising receive the plurality of images from the detector assembly;', 'identify at least one of a best focus image or a best astigmatism image of the plurality of images by analyzing one or more image quality parameters of at least some of the images of the plurality of the images; and', 'direct the multi-beam source to adjust at least one of focus or astigmatism of one or more electron beams based on at least one of focus or astigmatism of an electron beam corresponding with at least one of the identified best focus ...

FLIGHT CONTROL PUMP SYSTEMS

A flight control pump system includes an electrical machine configured to operate in a motor mode and in a generator mode. A pump is operatively connected to be driven by the electrical machine in the motor mode. An overriding clutch is operatively connected to the electrical machine and to the pump to transfer torque from a main transmission to drive the pump and the electrical machine in the generator mode, and to decouple the main transmission from the electrical machine and the pump in the motor mode. 1. A flight control pump system comprising:an electrical machine configured to operate in a motor mode and in a generator mode;a pump operatively connected to be driven by the electrical machine in the motor mode; andan overriding clutch operatively connected to the electrical machine and to the pump to transfer torque from a main transmission to drive the pump and the electrical machine in the generator mode, and to decouple the main transmission from the electrical machine and the pump in the motor mode.2. A system as recited in claim 1 , further comprising a main rotorcraft transmission configured to drive a rotorcraft main rotor under power from a main powerplant claim 1 , wherein the main rotorcraft transmission is operatively connected to the overriding clutch to drive the pump and the electrical machine in the generator mode.3. A system as recited in claim 1 , wherein an accessory gearbox operatively connects the electrical machine claim 1 , the pump claim 1 , and the overriding clutch.4. A system as recited in claim 1 , wherein the pump is in fluid communication with a plurality of hydraulic flight control servos.5. A system as recited in claim 1 , wherein the electrical machine is electrically connected to an aircraft power system to supply the aircraft power system in the generator mode.6. A system as recited in claim 1 , wherein the electrical machine is electrically connected to receive power from an auxiliary power system in the motor mode.7. A system ...

AMORPHOUS AND CRYSTALLINE FORMS OF IDO INHIBITORS

The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-(1S,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. Crystalline (R)-N-(4-chlorophenyl)-2-((1S ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide monohydrate Form 2 , characterized by a powder X-ray diffraction pattern comprising at least one peak selected from 9.4 , 12.4 , 17.2 , 17.6 , 20.1 , 21.1 , and 21.6 degrees 2Θ±0.2 degrees 2Θ.8. The crystalline (R)-N-(4-chlorophenyl)-2-((1S claim 7 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide monohydrate Form 2 of claim 7 , characterized by a powder X-ray diffraction pattern comprising two peaks selected from 9.4 claim 7 , 12.4 claim 7 , 17.2 claim 7 , 17.6 claim 7 , 20.1 claim 7 , 21.1 claim 7 , and 21.6 degrees 2Θ±0.2 degrees 2Θ.9. The crystalline (R)-N-(4-chlorophenyl)-2-((1S claim 7 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide monohydrate Form 2 of claim 7 , characterized by a powder X-ray diffraction pattern comprising three peaks selected from 9.4 claim 7 , 12.4 claim 7 , 17.2 claim 7 , 17.6 claim 7 , 20.1 claim 7 , 21.1 claim 7 , and 21.6 degrees 2Θ±0.2 degrees 2Θ.10. The crystalline (R)-N-(4-chlorophenyl)-2-((1S claim 7 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide monohydrate Form 2 of claim 7 , characterized by a powder X-ray diffraction pattern comprising four peaks selected from 9.4 claim 7 , 12.4 claim 7 , 17.2 claim 7 , 17.6 claim 7 , 20.1 claim 7 , 21.1 claim 7 , and 21.6 degrees 2Θ±0.2 degrees 2Θ.11. (canceled)12. Crystalline (R)-N-(4-chlorophenyl)-2-((1S claim 7 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide methanesulfonic acid Form 1 claim 7 , characterized by a powder X-ray diffraction pattern comprising at least one peak selected from 12.2 claim 7 , 12.6 ...

SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION

The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds. 116-. (canceled)1922-. (canceled) This application claims the benefit of U.S. Provisional Application No. 62/527,821, filed Jun. 30, 2017, U.S. Provisional Application No. 62/527,835, filed Jun. 30, 2017, and U.S. Provisional Application No. 62/649,155, filed Mar. 28, 2018, the entireties of which are incorporated by reference herein.The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.Indoleamine 2,3-dioxygenase (IDO; also known as IDO1) is an IFN-γ target gene that plays a role in immunomodulation. IDO plays a major role in immune regulation, and its immunosuppressive function manifests in several manners. A pathophysiological link exists between IDO and cancer. Disruption of immune homeostasis is intimately involved with tumor growth and progression, and the production of IDO in the tumor microenvironment appears to aid in tumor growth and metastasis. Moreover, increased levels of IDO activity are associated with a variety of different tumors (Brandacher, G. et al., 12(4):1144-1151 (Feb. 15, 2006)). In addition to cancer, IDO has been implicated in, among other conditions, immunosuppression, chronic infections, and autoimmune diseases or disorders (e.g., rheumatoid arthritis).Substituted quinolinylcyclohexylpropanamide pharmaceutical compounds that inhibit IDO and are useful for the treatment of cancer have been previously described. See, e.g., WO2016/073770. Improved methods of making such compounds, which reduce production costs and improve production safety, are, therefore, needed.The disclosure is directed to methods of making compounds of formula I, or stereoisomers thereof:contacting the compound of formula III, or a stereoisomer thereof, with a suitable organic acid, in a suitable aqueous solvent, for a time and at a temperature sufficient for hydrolysis and decarboxylation and to ...

AMORPHOUS AND CRYSTALLINE FORMS OF IDO INHIBITORS

The present disclosure relates to amorphous and crystalline forms of (R)—N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them. 1. Crystalline (R)—N-(4-chlorophenyl)-2-((1S ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide Form 4.2. The crystalline (R)—N-(4-chlorophenyl)-2-((1S claim 1 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide Form 4 of claim 1 , characterized by a powder X-ray diffraction pattern comprising at least one peak selected from 7.6 claim 1 , 12.0 claim 1 , 13.5 claim 1 , 14.4 claim 1 , 17.6 claim 1 , 20.1 claim 1 , 20.7 claim 1 , and 22.0 degrees 2θ±0.2 degrees 2θ.3. The crystalline (R)—N-(4-chlorophenyl)-2-((1S claim 1 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide Form 4 of claim 1 , characterized by a powder X-ray diffraction pattern comprising two peaks selected from 7.6 claim 1 , 12.0 claim 1 , 13.5 claim 1 , 14.4 claim 1 , 17.6 claim 1 , 20.1 claim 1 , 20.7 claim 1 , and 22.0 degrees 2θ±0.2 degrees 2θ.4. The crystalline (R)—N-(4-chlorophenyl)-2-((1S claim 1 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide Form 4 of claim 1 , characterized by a powder X-ray diffraction pattern comprising three peaks selected from 7.6 claim 1 , 12.0 claim 1 , 13.5 claim 1 , 14.4 claim 1 , 17.6 claim 1 , 20.1 claim 1 , 20.7 claim 1 , and 22.0 degrees 2θ±0.2 degrees 2θ.5. The crystalline (R)—N-(4-chlorophenyl)-2-((1S claim 1 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide Form 4 of claim 1 , characterized by a powder X-ray diffraction pattern comprising four peaks selected from 7.6 claim 1 , 12.0 claim 1 , 13.5 claim 1 , 14.4 claim 1 , 17.6 claim 1 , 20.1 claim 1 , 20.7 claim 1 , and 22.0 degrees 2θ±0.2 degrees 2θ.6. Crystalline (R)—N-(4-chlorophenyl)-2-((1S claim 1 ,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide mono-hydrate Form 2.7. The crystalline (R)—N-(4- ...

SUBSTITUTED QUINOLINYLCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION

The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds. 2. The method of claim 1 , wherein the Calkoxide salt is sodium t-amylate and the{'sub': '1-6', 'di-Calkyl-malonate is di-tert-butyl malonate.'}3. The method of claim 1 , wherein the organic acid is methanesulfonic acid.4. The method of claim 1 , wherein Ris methyl.6. The method of claim 5 , wherein the cerium halide is CeCl claim 5 , or a hydrate thereof claim 5 , and the hydride source is NaBH.7. The method of claim 5 , wherein X is Cl and Ris methyl.8. The method of claim 5 , wherein the alkyl-amine base is EtN.10. The method of claim 9 , wherein n is 1.11. The method of or claim 9 , wherein Y is Cl.12. The method of claim 9 , wherein the Calkylsilylamine is NaHMDS.13. The method of claim 9 , wherein the hydroxide base is KOH or NaOH.14. The method of claim 9 , wherein the mineral acid is HCl.19. Compound 1 claim 17 , or a stereoisomer thereof claim 17 , or a pharmaceutically acceptable salt thereof claim 17 , for example claim 17 , methanesulfonic acid salt claim 17 , or a co-crystal thereof claim 17 , prepared according to . This application claims the benefit of U.S. Provisional Application No. 62/527,821, filed Jun. 30, 2017, U.S. Provisional Application No. 62/527,835, filed Jun. 30, 2017, and U.S. Provisional Application No. 62/649,155, filed Mar. 28, 2018, the entireties of which are incorporated by reference herein.The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.Indoleamine 2,3-dioxygenase (IDO; also known as IDO1) is an IFN-γ target gene that plays a role in immunomodulation. IDO plays a major role in immune regulation, and its immunosuppressive function manifests in several manners. A pathophysiological link exists between IDO and cancer. Disruption of immune homeostasis is intimately involved with tumor growth and progression, and the production of IDO in the tumor ...

Low Latency Data Transmission Network

A communications networking having reduced transmission latency and improved reliability is described. To reduce signal transmission latency, network management data is removed from a data stream to prioritize the transmission of payload data at higher transmission rates. Management data is returned to the data stream in such a way that it minimizes an impact to payload transmission rates. To improve communications network reliability, the network is configured to form a primary communication path and a redundant communication path. Upon failure of a transceiver at one node, the network engages redundant transceivers on a per-node basis thereby using a segment of the redundant communication path. The data stream is returned to the primary communication path upon circumvention of the failed transceiver. 1. A method for transmitting data through a communications network comprising a plurality of nodes , each node comprising a plurality of transceiver systems , the method comprising:receiving, using a receiving transceiver system of an intermediate node, a data stream comprising payload data and management data, the management data configured to monitor and control the nodes of the communications network;removing the management data from the data stream;transmitting the payload data using a sending transceiver system of the intermediate node;identifying, using the intermediate node, a destination node for the management data;responsive to identifying the destination node as the intermediate node, executing an instruction with respect to the intermediate node, the instruction contained within the management data; andtransmitting, using the sending or receiving transceiver system, a response to the instruction.2. The method of claim 1 , wherein the data stream is received at a first transceiver of the receiving transceiver system claim 1 , the first transceiver configured to transmit and receive data using an optical communications frequency.3. The method of claim 2 , ...

Data Augmentation for Convolutional Neural Network-Based Defect Inspection

Systems and methods for providing an augmented input data to a convolutional neural network (CNN) are disclosed. Wafer images are received at a processor. The wafer image is divided into a plurality of references images each associated with a die in the wafer image. Test images are received. A plurality of difference images are created by differences the test images with the reference images. The reference images and difference images are assembled into the augmented input data for the CNN and provided to the CNN. 1. A method for providing an augmented input data to a convolutional neural network (CNN) comprising:receiving, at a processor, a wafer image;dividing, using the processor, the wafer image into a plurality of reference images, each reference image associated with a die in the wafer image;receiving, at the processor, one or more test images;creating a plurality of difference images, using the processor, by differencing the one or more test images with one or more of the plurality of reference images;assembling, using the processor, the plurality of reference images and the plurality of difference images into the augmented input data for the CNN; andproviding, using the processor, the augmented input data to the CNN.2. The method of claim 1 , further comprising:performing, using an image data acquisition subsystem, a wafer scan;converting, using an image data acquisition subsystem, the wafer scan into the wafer image; andconverting, using the image data acquisition subsystem, the wafer scan into the one or more test images.3. The method of claim 1 , further comprising:creating a plurality of defect-of-interest (DOI) images, using the processor, by differencing one or more test images having a DOI with one or more of the plurality of the reference images and merging the differenced images with one or more of the plurality of test images; andassembling, using the processor, the plurality of DOI images into the augmented input data for the CNN.4. The method of ...

DRILL ATTACHMENT FOR CANNULATED SURGICAL DRILLS

A hammer drill attachment is provided for attachment to a bi-directional surgical drill. The attachment comprises a lengthwise adapter to engage a chuck of the surgical drill, a transmission mechanism, and a quick-release mechanism. The transmission mechanism comprises a pair of toothed plates, the teeth of a proximal plate configured to permit engagement with the teeth of a distal plate. When the proximal plate rotates in a first direction, the proximal plate transmits a rotational motion to the distal plate. When the proximal plate rotates in a second direction, the proximal plate transmits an axial percussive force to the distal plate. The quick-release mechanism comprises a socket to receive a collet, a socket seater, and a latching arm to move the socket seater with respect to the socket, thereby seating or unseating the collet in the socket. 1. A quick-release mechanism for a collet , the mechanism comprising: a proximal socket flange, and', 'a distal socket flange distal to the proximal socket flange;, 'a socket configured to receive the collet in a collet lumen, the socket comprising a socket lumen configured to receive the socket, wherein the socket lumen is co-axial to the collet lumen,', 'a socket seater flange disposed between the proximal socket flange and the distal socket flange, and', 'a socket seater stub;, 'a socket seater comprisinga return spring disposed on an exterior surface of the socket seater; anda latching arm in contact with the socket seater stub, the latching arm having a first state, a second state, and a third state, wherein the latching arm moves in a direction under a force with the return spring.2. The mechanism of claim 1 , wherein the socket seater flange claim 1 , when the latching arm is placed in the first state claim 1 , is configured to move the proximal socket flange in a proximal direction claim 1 , thereby securing an exterior surface of the collet against an inner surface of the collet lumen.3. The mechanism of claim 2 , ...

VERTEBRAL COLUMN IMPLANT

A vertebral column implant assembly for insertion between two vertebrae, the assembly comprising: a superior implant body for engagement with a superior vertebra; an inferior implant body for engagement with an inferior vertebra; a central implant body adapted to be positioned in between the superior implant body and the inferior implant body, the central implant body further comprising: a first fastening arrangement positioned on an upper face of the central implant body to engage and fasten the superior implant body; and a second fastening arrangement positioned on a lower face of the central implant body to engage and fasten the inferior implant body; wherein each of the central implant body, the superior implant body and the inferior implant body comprises internal walls defining respective passages, such that the first and second fastening arrangements are positioned along inner marginal portions of the superior and inferior implant bodies respectively and structured to engage the central body with the superior and inferior implant bodies respectively to interconnect each of the respective passages to form a continuous passage to allow graft material to be positioned therein. 2. A vertebral column implant assembly in accordance with wherein the first arrangement of the central implant body further comprises: a first plurality of projection formations adapted to be inserted into projection receiving portions positioned along an in-use lower portion of the superior implant body; and wherein the second fastening arrangement comprises a second plurality of projection formations adapted to be inserted into projection receiving portions positioned along an in-use upper portion of the inferior implant body.3. A vertebral column implant assembly in accordance with wherein the first arrangement of the central implant body further comprises: a first plurality of receiving portions adapted to receive projection formations positioned along an in-use lower portion of the ...

FAIL-SAFE TAIL ROTOR SYSTEM

According to an aspect, a clevis assembly includes a shackle having two ends, each end respectively including an aperture, a structure connecting the apertures and housing a bearing, and a shearing device that includes a frangible point and is in operable communication with the bearing, where the shearing device is housed in a hollow portion of the structure. 1. A clevis assembly comprising:a shackle having two ends, each end respectively comprising an aperture;a structure connecting the apertures and housing a bearing; anda shearing device comprising a frangible point and in operable communication with the bearing, wherein the shearing device is housed in a hollow portion of the structure.2. The clevis assembly of further comprising:a piston in operable communication with the shearing device and restrained from spinning;wherein the shearing device is operable to shear under a pressure greater than a threshold amount and allow the piston to spin.3. The clevis assembly of claim 1 , wherein a proximal end of the shearing device extends outward from an aperture of an end of the two shackle ends and a distal end of the shearing device is arranged within an aperture of an outer raceway of the bearing.4. The clevis assembly of further comprising a threaded insert arranged between an inner surface of the structure and an outer surface of the shearing device.5. The clevis assembly of claim 1 , wherein an inner raceway of the bearing is in operable communication with a piston.6. The clevis assembly of claim 4 , wherein the piston comprises a plurality of splines such that coupling the piston with the bearing creates a spline joint.7. The clevis assembly of claim 1 , wherein the shearing device is a cylindrical rod claim 1 , and wherein the frangible point is a portion of the cylindrical rod having a diameter smaller than another portion of the cylindrical rod.8. The clevis assembly of claim 1 , wherein the frangible point is a portion of the shearing device comprised of a ...

SPINAL FIXATION AND GUIDANCE SYSTEM AND METHOD

A spinal fixation and guidance system comprising: a spinal cage configured to be received between adjacent first and second vertebrae; and an alignment assembly comprising: a guidance element for guiding one or more fasteners for fastening said spinal cage relative to said adjacent vertebrae; or fastening said spinal plate to adjacent vertebrae and a mating element comprising engagement portions for mating with said guidance elements relative to the spinal cage. 1. A spinal fixation and guidance system comprising:a spinal cage configured to be received between adjacent first and second vertebrae; and a mating element comprising a first engagement portion for engagement with the spinal cage and a second engagement portion for engagement with a guiding assembly, the mating element being adapted to be releasably connected to the spinal cage;', 'wherein the guidance assembly further comprises: a guidance element comprising guiding portions for guiding one or more fasteners for fastening said spinal cage relative to said adjacent vertebrae, 'an alignment assembly comprising2. A spinal fixation and guidance system in accordance with wherein the guidance element is of a first type or a second type wherein the guidance element of the first type guides fasteners for fastening the spinal cage directly to bone tissue surrounding said implant and wherein the guidance element of the second type guides fasteners to fasten a spinal plate simultaneously to the implant and the adjacent vertebrae; and wherein in a first operable configuration the engagement portion of the mating element is configured to engage the guidance element of the first type and in a second operable configuration the mating element is adapted to engage the guidance element of the second type.3. A spinal fixation and guidance system in accordance with wherein:the guidance element of the first type comprises one or more guiding passages for guiding said fasteners into corresponding one or more fastener receiving ...

Method and System for Focus Adjustment of a Multi-Beam Scanning Electron Microscopy System

A scanning electron microscopy system is disclosed. The system includes a multi-beam scanning electron microscopy (SEM) sub-system. The SEM sub-system includes a multi-beam electron source configured to form a plurality of electron beams, a sample stage configured to secure a sample, an electron-optical assembly to direct the electron beams onto a portion of the sample, and a detector assembly configured to simultaneously acquire multiple images of the surface of the sample. The system includes a controller configured to receive the images from the detector assembly, identify a best focus image of images by analyzing one or more image quality parameters of the images, and direct the multi-lens array to adjust a focus of one or more electron beams based on a focus of an electron beam corresponding with the identified best focus image. 1. A multi-beam scanning electron microscopy apparatus comprising: a multi-beam electron source configured to form a plurality of electron beams;', 'a sample stage configured to secure a sample;', 'an electron-optical assembly including a set of electron-optical elements configured to direct at least a portion of the plurality of electron beams onto a portion of the sample; and', 'a detector assembly configured to simultaneously acquire a plurality of images of the surface of the sample, each image associated with an electron beam of the plurality of electron beams;, 'a multi-beam scanning electron microscopy sub-system comprising receive the plurality of images from the detector assembly;', 'identify at least one of a best focus image or a best astigmatism image of the plurality of images by analyzing one or more image quality parameters of at least some of the images of the plurality of the images; and', 'direct the multi-beam source to adjust at least one of focus or astigmatism of one or more electron beams based on at least one of focus or astigmatism of an electron beam corresponding with at least one of the identified best focus ...

WATER-SOLUBLE FORMULATIONS, METHODS OF MAKING AND USE

Water-soluble formulations including cannabinoids or a -derived compound for use in beverages and foods, methods of preparing the formulations, and methods of preparing beverages and foods including the formulations are disclosed herein. In other embodiments are provided water-soluble formulations that are physically and chemically stable, transparent or translucent in colour, calorie-free, and have minimal flavour. 1cannabis. A water-soluble formulation comprising a cannabinoid or a -derived compound; an emulsifier; and a glycerin-based carrier surfactant.2. The water-soluble formulation of claim 1 , further comprising a carrier oil.3. The water-soluble formulation of claim 2 , wherein the carrier oil is comprised of monoglycerides.4. The water-soluble formulation of claim 3 , wherein the monoglycerides comprise glyceryl monostearate claim 3 , glyceryl hydroxystearate claim 3 , glyceryl monoleate claim 3 , winterized glyceryl monoleate claim 3 , monolaurin claim 3 , glyceryl monolinoleate claim 3 , or any combination thereof.5cannabis. The water-soluble formulation of claim 2 , which comprises up to 10% by weight of the cannabinoid or -derived compound; up to 10% by weight of the carrier oil claim 2 , and up to 10% by weight of the emulsifier.6cannabis. The water-soluble formulation of claim 2 , which comprises the cannabinoid or -derived compound; the carrier oil claim 2 , and the emulsifier at an about equivalent amount by weight.7. The water-soluble formulation of claim 1 , which is an emulsion.8. The water-soluble formulation of claim 1 , wherein the cannabinoid is Cannabigerolic Acid (CBGA) claim 1 , Cannabigerolic Acid monomethylether (CBGAM) claim 1 , Cannabigerol (CBG) claim 1 , Cannabigerol monomethylether (CBGM) claim 1 , Cannabigerovarinic Acid (CBGVA) claim 1 , Cannabigerovarin (CBGV) claim 1 , Cannabichromenic Acid (CBCA) claim 1 , Cannabichromene (CBC) claim 1 , Cannabichromevarinic Acid (CBCVA) claim 1 , Cannabichromevarin (CBCV) claim 1 , ...

PARTIAL CREDITS CASHOUT GAMING UNIT

Disclosed are a system and method providing a player the opportunity to cash out a portion of credits accumulated during gaming. Anonymous cashing out of credit is available to a player through routes both external and internal to a gaming machine. 1. In a gaming system including a central data system and a gaming transaction manager coupled to the central data system , a video game apparatus providing partial cashout , comprising: a gaming processor , comprising circuitry for: receiving a partial cashout request from a player of the video game apparatus; and requesting data representing a partial cashout corresponding to the partial cashout request from the gaming transaction manager; and a ticket printer for printing a ticket reflecting the partial cashout representative data before notification of recordation of the partial cashout by the central data system , wherein the ticket printer is juxtapositioned adjacent to the video game apparatus.2. The video game apparatus of claim 1 , wherein the gaming processor further comprises circuitry for: presenting one or more partial cashout offer amounts; and receiving a player choice from among the partial cashout offer amounts.3. The video game apparatus of claim 1 , wherein the gaming processor circuitry requests partial cashout representative data including possible cashout amounts.4. The video game apparatus of claim 1 , wherein the gaming processor determines possible cashout amounts.5. The video game apparatus of claim 1 , wherein the gaming processor requests partial cashout representative data comprising data representing at least one bar codes for the tickets.6. The video game apparatus of claim 1 , wherein the electronic gaming unit circuitry sends data confirming printing of the ticket to the gaming transaction manager.7. The video game apparatus of claim 1 , wherein the electronic gaming unit circuitry presents a partial credit cashout touch screen button to the player.8. The video game apparatus of claim 1 , ...

GAME TRANSACTION MODULE INTERFACE TO SINGLE PORT PRINTER

A gaming device includes a game module for presenting instances of a game title and a game transaction module for interfacing with a system controller of a game entertainment center. The gaming device further includes a printer for printing various items such as tickets, coupons, vouchers, and other promotional material. The gaming device further includes a printer manager for arbitrating print job conflicts. 1. A method of operating a gaming system comprising a gaming device having a game module and a printer device with only one communications port , wherein the game module provides instances of a game title and implements a slot-accounting-system protocol , the method comprising the steps of:communicatively coupling a game transaction module configured to interface with the game module in accordance to the slot-accounting-system protocol and configured to interface with a remote computing device in accordance with a game-to-system protocol to the remote computing device;communicatively coupling the game transaction module to the only one communications port of the printer device; andproviding a printer manager configured to arbitrate print jobs for the printer device.2. The method of comprising:configuring the printer manager to communicate with the printer device;configuring the printer manager to buffer print jobs for the printer device; andconfiguring the printer manager to provide the printer device with a respective print job of one of the buffered print jobs only in response to receiving an indicator of printer device availability indicative of the printer device being available to print content corresponding to the respective print job.3. The method of comprising:configuring the printer manager to query the printer device for the indicator of printer device availability.4. The method of comprising:configuring the printer manager to provide the printer device with respective ones of the buffered print jobs on a first-in/first-out basis.5. The method of ...

MERGING MULTIPLE UNSYNCHRONIZED STREAMS OF RELATED EVENTS AND MULTI-TENANT SUPPORT

A method and system for handling asynchronous data streams in a multi-tenant system. The process includes receiving at least a first stream of data and a second stream of data by a rules engine, determining by pattern matching of the rules engine, whether data in the first stream or data in the second stream meet conditions of a rule defined by a tenant of the multi-tenant system, and implementing by the rules engine the rule including a set of actions to modify data from the second data stream, in response to the data in the first stream matching the conditions the rule. 1. A method for handling asynchronous event streams in a multi-tenant system , the method comprising:receiving at least a first stream of events and a second stream of events by a rules engine;determining by pattern matching of the rules engine, whether data in events of the first stream or data in events of the second stream meet conditions of a rule defined by a tenant of the multi-tenant system; andimplementing by the rules engine the rule including a set of actions to modify data from events of the second stream, in response to the data in the events of the first stream matching the conditions of the rule.2. The method of claim 1 , wherein the rules engine is implemented in a cluster node of a cluster computing environment.3. The method of claim 1 , further comprising:initiating, by a cluster configurator, a set of cluster nodes in a cluster computing environment; andassigning, by the cluster configurator, each cluster node in the set of cluster nodes to process at least a first topic of an event management platform for a first tenant of the multi-tenant system.4. The method of claim 3 , further comprisingconfiguring a payload router to route events from the event management platform to a respective cluster node in the set of cluster nodes according to a topic and tenant.5. The method of claim 1 , further comprising:notifying, by a cluster monitor, a payload router and a set of cluster nodes to ...

Carrier frequency and phase recovery in quadrature encoded e-band communications

A mechanism for retrieval of carrier frequency and carrier phase in a received modulated carrier waveform. Retrieval of carrier frequency and carrier phase can be implemented in an analog electrical circuit, using a field programmable gate array (FPGA), or in computer code. Independent of the implementation, the mechanism performs frequency and primary phase recovery by forcing transforms of a pilot tone in the upper and lower sidebands to the same frequency using a feedback loop. The difference-in-magnitudes of the channelized pilot are used by a phase lock loop to perform secondary phase recovery in a manner that also resolves phase sign ambiguity. Benefits of this mechanism include improved phase lock loop tracking performance and a reduction of noise in the data demodulated from the received carrier waveform.

APPARATUS AND METHODS FOR COMBINED BRIGHTFIELD, DARKFIELD, AND PHOTOTHERMAL INSPECTION

Disclosed are methods and apparatus for detecting defects or reviewing defects in a semiconductor sample. The system has a brightfield (BF) module for directing a BF illumination beam onto a sample and detecting an output beam reflected from the sample in response to the BF illumination beam. The system has a modulated optical reflectance (MOR) module for directing a pump and probe beam to the sample and detecting a MOR output beam from the probe spot in response to the pump beam and the probe beam. The system includes a processor for analyzing the BF output beam from a plurality of BF spots to detect defects on a surface or near the surface of the sample and analyzing the MOR output beam from a plurality of probe spots to detect defects that are below the surface of the sample. 1. A system for detecting defects or reviewing defects in a semiconductor sample , the system comprising:a brightfield (BF) module for directing a BF illumination beam on a BF spot on a sample and detecting an output beam reflected from the BF spot on the sample in response to the BF illumination beam being directed on the BF spot;a modulated optical reflectance (MOR) module for directing a pump beam to a pump spot on the sample, directing a probe beam to a probe spot on the sample, and detecting a MOR output beam from the probe spot in response to the pump beam and the probe beam, wherein the probe spot is coincident with the pump spot; and causing the BF module to scan the BF illumination beam on a plurality of BF spots on the sample and detect an output beam from the plurality of BF spots;', 'causing the MOR module to scan the pump and probe beam on a plurality of pump and probe spots, respectively, and to detect a MOR output beam from the plurality of probe spots;', 'analyzing the BF output beam from the plurality of BF spots to detect one or more defects on a surface or near the surface of the sample; and', 'analyzing the MOR output beam from the plurality of probe spots to detect one ...

SPINAL FIXATION SYSTEM

An alignment assembly for aligning and positioning an interbody plate over a disc space in between two adjacent vertebrae, the assembly including: a fastener having a long axis and a plate engagement including opposed wings converging towards the axis; and a mate for the fastener configured to receive the fastener thereover at a first end and having a releasable connector with a releasable attachment below the first end; wherein the fastener is releasably secured to the mate for the fastener as it moves therealong; and wherein during use the opposed wings contact one or more edges of an aligning aperture of the interbody plate thereby bringing the interbody plate into alignment with the fastener. 1. An alignment assembly for aligning and positioning an interbody plate over a disc space in between two adjacent vertebrae , the assembly comprising:a fastener having a long axis and a plate engagement comprising opposed wings converging towards said long axis; anda mate for the fastener configured to receive the fastener thereover at a first end and having a releasable connector with a releasable attachment below the first end;wherein the fastener is releasably secured to the mate for the fastener as it moves therealong; andwherein during use, the opposed wings contact one or more edges of an aligning aperture of the interbody plate, thereby bringing the interbody plate into alignment with the fastener.2. The alignment assembly of wherein the fastener includes an upper body having a driver engagement.3. The alignment assembly of wherein the fastener comprises a lower body having the plate engagement.4. The alignment assembly of wherein said wings comprise respective plate engaging surfaces such that claim 1 , in response to one of said wings engaging with a front and/or rear wall forming said edges of the aligning aperture in the plate claim 1 , the plate is configured to shift in a direction towards the other of said wings.5. The alignment assembly of wherein the mate ...

INTRAMEDULLARY FIXATION SYSTEM FOR MANAGEMENT OF PELVIC AND ACETABULAR FRACTURES

Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated. 191-. (canceled)92. A method of placing a guide wire into an intramedullary canal , the method comprising:inserting a guide wire into an intramedullary canal of a bone, the guide wire having a distal end with a bent section and a sharpened distal tip; androtating the guide wire periodically, while inserting the guide wire, to create a succession of short curved paths in order to steer the guide wire.93. The method of claim 92 , further comprising:rotating the succession of short curved paths to be substantially 180 degrees opposed to each other such that the wire creates a generally straight path.94. The method of claim 92 , wherein the method further comprises:pausing the inserting of the guide wire while rotating the guide wire.95. The method of claim 92 , further comprising:attaching a flexible cannulated reamer over the guide wire.96. A guide wire comprising:a guide wire body having a distal section;a bent section on the distal section of the body; anda sharpened distal tip.97. The guide wire of claim 96 , wherein the guide wire is about 1.0 to about 1.5 mm in diameter.98. The guide wire of claim 96 , wherein the guide wire is made substantially of stainless steel.99. The guide wire of claim 96 , wherein the guide wire is made substantially of one or more nickel-titanium alloys (NiTi). This Application is a continuation of U.S. patent application Ser. No. 14/357,917, which is the U.S. National Stage Entry of International Application No. PCT/CA2012/050808, filed Nov. 14 ...

A drill attachment for cannulated surgical drills

A hammer drill attachment is provided for attachment to a bi-directional surgical drill. The attachment comprises a lengthwise adapter to engage a chuck of the surgical drill, a transmission mechanism, and a quick-release mechanism. The transmission mechanism comprises a pair of toothed plates, the teeth of a proximal plate configured to permit engagement with the teeth of a distal plate. When the proximal plate rotates in a first direction, the proximal plate transmits a rotational motion to the distal plate. When the proximal plate rotates in a second direction, the proximal plate transmits an axial percussive force to the distal plate. The quick-release mechanism comprises a socket to receive a collet, a socket seater, and a latching arm to move the socket seater with respect to the socket, thereby seating or unseating the collet in the socket.

Novel battery systems based on two-additive electrolyte systems including 1,2,6-oxodithiane-2,2,6,6-tetraoxide

Improved battery systems with two-additive mixtures including in an electrolyte solvent that is a carbonate solvent, an organic solvent, a non-aqueous solvent, methyl acetate, or a combination of them. The positive electrode of the improved battery systems may be formed from lithium nickel manganese cobalt compounds, and the negative electrode of the improved battery system may be formed from natural or artificial graphite.

VENTED INSULATED SPA COVER

An insulated spa cover () contains a thermal insulating core (), a top cover () with an average permeance of at least 57.2 nanograms/Pascal*seconds*square meters, and a hydrostatic head test value of at least 5,000 Pascals, a vapor barrier () and optionally a bottom sheet () apart from the vapor barrier. Venting pathways are defined around the thermally insulating core to facilitate escape of water vapor. 1. An insulated spa cover comprising:(a) a thermally insulating core having opposing top and bottom primary sides;(b) a top cover that extends over and entirely covers the top primary side of the thermally insulating core, the top cover having an average permeance over the entire top cover of at least 57.2 nanograms/Pascal*seconds*square meters as determined according to ASTM E96 Desiccant Method and any 10 square centimeter portion of the top cover has a hydrostatic head test value of at least 5,000 Pascals determined according to AATCC-127;(c) a vapor barrier layer proximate to and covering at least 75% of the bottom primary side of the thermally insulating core, the vapor barrier layer having a lower average permeance than the top cover as determined according to ASTM E96 Desiccant Method;(d) optionally, a bottom sheet apart from the vapor barrier; (i) the bottom sheet if present, and if not then the vapor barrier layer, serves as a bottom cover that is attached to the top cover to form an enclosure that surrounds the thermally insulating core, and if the bottom cover is separate from the vapor barrier the enclosure further surrounds the vapor barrier layer between the thermally insulating core and the bottom cover;', '(ii) venting pathways are defined within the enclosure formed by the top cover and bottom cover, the venting pathways providing a vapor path from inside the bottom cover to the top cover with a permeance that is greater than the average permeance of the bottom cover; and', '(iii) the insulated spa cover having opposing top and bottom primary sides ...

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 1. A method of treating , preventing , or reducing a risk of a disease , disorder , condition , or cosmetic indication in which aldehyde toxicity is implicated in a subject in need thereof , comprising administering topically or systemically to the subject a compound comprising a primary amine , provided that the disease , disorder , or condition is not macular degeneration or Stargardt disease.2. The method of claim 1 , wherein the disease claim 1 , disorder claim 1 , or condition is an ocular disorder claim 1 , provided that the ocular disorder is not macular degeneration or Stargardt disease.3. The method of claim 2 , wherein the ocular disorder is selected from the group consisting of dry eye syndrome claim 2 , cataracts claim 2 , keratoconus claim 2 , bullous and other keratopathy claim 2 , Fuch's endothelial dystrophy claim 2 , allergic conjunctivitis claim 2 , ocular cicatricial pemphigoid claim 2 , conditions associated with PRK healing and other corneal healing claim 2 , conditions associated with tear lipid degradation or lacrimal gland dysfunction claim 2 , uveitis claim 2 , scleritis claim 2 , ocular Stevens Johnson Syndrome claim 2 , and ocular rosacea.4. The method of claim 3 , wherein the ocular disorder is dry eye syndrome.5. The method of claim 3 , wherein the ocular disorder is a condition associated with PRK healing and other corneal healing.6. The method of claim 3 , wherein the ocular disorder is selected from the group consisting of uveitis claim 3 , scleritis claim 3 , ocular Stevens Johnson Syndrome ...

CANNABIS PLACEBO COMPOSITIONS, DELIVERY VEHICLES AND A METHOD FOR COLOUR MATCHING/NEUTRALIZATION OF CANNABIS PRODUCTS

Disclosed herein are cannabis placebo compositions having an appearance, odor and flavour to match that of an active cannabis product, as well as methods for colour matching and colour neutralization of cannabis products. The compositions include a colourant to provide a colour match between the cannabis placebo composition and the active cannabis product; and a terpene, an ester, a flavonoid, or any combination thereof to provide an odor and flavour. 1. A cannabis placebo composition comprising:a base component matched to that of an active cannabis product;a colourant to provide a colour match between the cannabis placebo composition and the active cannabis product; anda terpene, an ester, a flavonoid, or any combination thereof to provide an odor and flavour match between the cannabis placebo composition and the active cannabis product,wherein the cannabis placebo composition is indistinguishable in appearance, odor and flavour from the active cannabis product.2. The cannabis placebo composition of claim 1 , wherein the base component is a carrier oil.3. The cannabis placebo composition of claim 2 , wherein the carrier oil is medium chain triglyceride (MCT) oil claim 2 , long chain triglyceride (LCT) oil claim 2 , coconut oil claim 2 , corn oil claim 2 , canola oil claim 2 , olive oil claim 2 , avocado oil claim 2 , vegetable oil claim 2 , flaxseed oil claim 2 , palm oil claim 2 , peppermint oil claim 2 , hemp oil claim 2 , sesame oil claim 2 , sunflower oil claim 2 , a winterized oil of long-chain mono- claim 2 , di- claim 2 , and tri-glycerides claim 2 , rice bran oil claim 2 , or any combination thereof.4. The cannabis placebo composition of claim 1 , wherein the colourant is derived from a source other than a cannabis plant.5. The cannabis placebo composition of claim 1 , wherein the colourant is synthetically produced or is derived from an extract from a plant other than cannabis.6. The cannabis placebo composition of claim 1 , wherein the colourant is ...

LEARNING BASED APPROACH FOR ALIGNING IMAGES ACQUIRED WITH DIFFERENT MODALITIES

Methods and systems for aligning images for a specimen acquired with different modalities are provided. One method includes acquiring information for a specimen that includes at least first and second images for the specimen. The first image is acquired with a first modality different than a second modality used to acquire the second image. The method also includes inputting the information into a learning based model. The learning based model is included in one or more components executed by one or more computer systems. The learning based model is configured for transforming one or more of the at least first and second images to thereby render the at least the first and second images into a common space. In addition, the method includes aligning the at least the first and second images using results of the transforming. The method may also include generating an alignment metric using a classifier. 1. A system configured to a ages for a specimen acquired with different modalities , comprising:one or more computer subsystems configured for acquiring information for a specimen, wherein the information comprises at least first and second images for the specimen, and wherein the first image is acquired with a first modality different from a second modality used to acquire the second image; andone or more components executed by the one or more computer subsystems, wherein the one or more components comprise a learning based model, wherein the one or more computer subsystems are configured to input the information for the specimen into the learning based model, wherein the learning based model is configured for transforming one or more of the at least first and second images to thereby render the at least first and second images into a common space, and wherein the one or more components are configured for aligning the at least the first and second images using results of said transforming.2. The system of claim 1 , wherein the first and second modalities generate the ...

APPARATUS FOR POSITIONING A BREAST FOR RADIATION TREATMENT

The present invention provides a method and apparatus to decrease acute and late skin toxicity for breast cancer patients undergoing radiation therapy. This invention will enable better breast positioning during therapy, eliminating skin folds and reducing the skin dose below that required for development of moist desquamation. The present invention has the potential to reduce the volume of normal tissue and organs at risk of being irradiated during a course of whole breast radiation therapy. 1. Apparatus for supporting a breast for radiation treatment , the apparatus comprising:a paddle comprising first and second generally planar faces oriented at a right angle to one another; anda support structure connected to hold the paddle at a desired position and orientation, the support structure adjustable to bring the first face against and supporting the inferior side of a patient's breast while the second face is against and supporting a lateral side of the patient's breast.2. Apparatus according to wherein the paddle comprises a curved central section connecting the first and second faces.3. Apparatus according to wherein the central section has a radius of curvature about an axis in the range of 30 mm to 70 mm.4. Apparatus according to wherein the first and second faces have top and bottom edges separated by distances in the range of about 5 cm to about 15 cm.5. Apparatus according to wherein the second face has a length in a direction parallel to a top edge of the second face that exceeds a distance between the top edge of the second face and a bottom edge of the second face.6. Apparatus according to wherein the paddle is detachably coupled to the support structure.7. Apparatus according to wherein the paddle is one of a pair of paddles made up of first and second paddles wherein the first and second paddles are mirror images of one another.8. Apparatus according to wherein the paddle is made of a carbon fibre composite material.9. Apparatus according to wherein the ...

Medical container

A medical container for use to deliver multiple syringe tubes. The medical container comprises at least container main body (10) and, disposed thereinside, hold member (30). The hold member (30) is provided with at least multiple cylindrical hold parts (6) for retaining syringe tubes. The container main body (10) is provided with at least peripheral part (4) disposed at the periphery of its opening and shelf part (20) disposed on the internal wall surface of the container to mount the hold member (30). The shelf part (20) has three or more ribs (1) for supporting the hold member (30). The medical container is structured so that by means of the ribs (1), the hold member (30) can be disposed in a position horizontal to the bottom face of the container main body (10). Thus, there is provided a medical container of structure realizing rapid attainment of sterile condition through various methods, easy attainment of a state for maintaining the sterile condition and, at delivery, fixing of syringe tubes held vertically by holder without rattling.

ALDEHYDE CONJUGATES AND USES THEREOF

The present invention provides compounds and methods of use thereof for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. 217-. (canceled)1948-. (canceled)50. The method of claim 49 , wherein the method treats developmental delay claim 49 , hypotonia claim 49 , severe expressive language impairment claim 49 , obsessive-compulsive disorder claim 49 , epilepsy claim 49 , ADHD claim 49 , or aggression associated with SSADHD.51. The method of claim 49 , wherein the method reduces accumulation of GABA in the subject caused by SSADHD.52. The method of claim 49 , wherein the method reduces accumulation of GHB in the subject caused by SSADHD.53. The method of claim 49 , wherein the method reduces accumulation of GABA and GHB in the subject caused by SSADHD.54. The method of claim 49 , wherein the subject is a human.56. The method of claim 55 , wherein the method comprises contacting brain slices of B6.129-Aldh5a1J (SSADH null) mice with the compound of formula A or a pharmaceutically acceptable salt thereof. Metabolic and inflammatory processes in cells generate toxic aldehydes, such as malondialdehyde (MDA) and 4-hydroxyl-2-nonenal (HNE or 4HNE). These aldehydes are highly reactive to proteins, carbohydrates, lipids and DNA, leading to chemically modified biological molecules, activation of inflammatory mediators such as NF-κB, and damage in diverse organs. For example, retinaldehyde can react with phosphatidylethanolamine (PE) to form a highly toxic compound called A2E, which is a component of lipofuscin believed to be involved in the development and progression of Age Related Macular Degeneration (AMD). Many ...

Intramedullary fixation system for management of pelvic and acetabular fractures

Devices for treating a bone and methods of inserting such devices into a bone are disclosed. A device for treating a bone may include a flexible tube, a stiffening mechanism and an actuator. The flexible tube has a distal end and a proximal end. The stiffening mechanism within the flexible tube is configured to cause the flexible tube to become rigid. The actuator is configured to cause the stiffening mechanism to cause the flexible tube to become rigid in response to the actuator being actuated.

Toxic aldehyde-related diseases and treatment

【課題】毒性アルデヒド、例えば、ＭＤＡおよびＨＮＥをスカベンジする第一級アミンの使用による、眼の障害、皮膚障害、びらん剤からの傷害性作用と関連する状態、ならびに自己免疫性、炎症性、神経系および心血管の疾患を含めた、アルデヒド毒性が病態形成に結びつけられている疾患、障害、または状態の処置、予防、および／またはそのリスクの低減の提供。【解決手段】本発明はまた、アルデヒド毒性が病態形成に結びつけられている疾患、障害、または状態の処置、予防、および／またはそのリスクの低減のための医薬の製造における本明細書に記載の化合物（例えば、第一級アミン化合物）の使用、あるいはアルデヒド毒性が病態形成に結びつけられている疾患、障害、または状態を処置し、予防し、かつ／またはそのリスクを低減することにおける本明細書に記載の化合物（例えば、第一級アミン化合物）の使用に関する。【選択図】なし

Nucleotide sequences of maize oleoyl-acp thioesterase and palmitoyl-acp thioesterase genes and their use in the modification of fatty acid content of oil

Genes encoding acyl-acyl carrier protein thioesterase enzymes have been isolated from maize. These genes, when expressed in a plant, can be used to create transgenic plants having altered oil profiles.

Nucleotide sequences of maize oleoyl-acp thioesterase and palmitoyl-acp thioesterase genes and their use in the modification of fatty acid content of oil

Genes encoding acyl-acyl carrier protein thioesterase enzymes have been isolated from maize. These genes, when expressed in a plant, can be used to create transgenic plants having altered oil profiles.

Nucleic acid encoding delta-9 desaturase

The present invention relates to nucleic acid molecules encoding delta 9 desaturase gene, and expression vectors, plant cells, and transgenic plants expressing delta 9 desaturase nucleic acid. The nucleic acid molecules of the present invention can be used, for example, to decrease delta 9 desaturase activity in plant cells, resulting in decreased unsaturated fatty acid production.

Aldehyde conjugate and use thereof

【課題】アルデヒドコンジュゲートを提供すること【解決手段】本発明は、毒性アルデヒド、例えば、ＭＤＡおよびＨＮＥをスカベンジする第一級アミンの使用による、眼の障害、皮膚障害、びらん剤からの傷害性作用と関連する状態、ならびに自己免疫疾患、炎症性疾患、神経系疾患および心血管疾患を含めた、アルデヒド毒性が病態形成に関係している疾患、障害、または状態の処置、予防、および／またはそのリスクの低減を提供する。本発明の化合物およびその組成物は、アルデヒド毒性が病態形成に関係している疾患、障害、または状態を処置し、予防し、かつ／またはそのリスクを低減するのに有用である。【選択図】図１

Solar metrology methods and apparatus

Methods and apparatus are presented to measure the photoluminescence of incoming wafers and extract parameters such as minority carrier life time, diffusion length, and defect density that may be used to predict final solar cell efficiency. In some examples, illumination light is supplied to a side of an as-cut silicon wafer and the induced luminescence measured from the same side and the opposite side of the wafer is used to determine an indication of the minority carrier lifetime. In another example, the luminescence induced by two instances of illumination light of different wavelength is used to determine an indication of the minority carrier lifetime. In another example, the spatial distribution of luminescence intensity over an area surrounding a focused illumination spot is used to determine an indication of the minority carrier lifetime. Other apparatus useful to passivate the surface of a wafer for inspection are also presented.

Connectors for use in systems and methods for reducing the risk of proximal junctional kyphosis

Systems and methods for reducing the risk of PJK, PJF, and other conditions are disclosed herein. In some embodiments, a longitudinal extension can be added to a primary fixation construct to extend the construct to one or more additional vertebral levels. The extension can be attached to a first attachment point, such as a spinous process of a vertebra that is superior to the primary construct. The extension can also be attached to a second attachment point, such as a component of the primary construct or an anatomical structure disposed inferior to the first attachment point. The extension can be more flexible than the primary construct and/or can limit motion to a lesser degree than the primary construct, thereby providing a more-gradual transition from the instrumented vertebrae to the natural patient anatomy adjacent thereto. The extension can be placed with little or no soft tissue disruption.

Automatic photomask and reticle inspection method and apparatus including improved defect detector and alignment sub-systems

IMPROVING THE ORIENTATION OF INSPECTION SYSTEMS BEFORE IMAGE RECORDING

Spinal fixation system

A spinal fixation system, the system including: an alignment assembly comprising: a fastening element; and a mating element configured to receiving the fastening element thereover and having a releasable connector, a fixation assembly comprising: a plate having an aligning aperture that allows the mating element to be received therethrough; and an implant configured to be received between adjacent vertebrae and releasably connect with the releasable connector, wherein the fastening element is configured to move along the mating element to engage with the plate.

Connectors for use in systems and methods for reducing the risk of proximal junctional kyphosis

Spinal fixation and guidance system and method

A spinal fixation and guidance system comprising: a spinal cage configured to be received between adjacent first and second vertebrae; and an alignment assembly comprising: a guidance element for guiding one or more fasteners for fastening said spinal cage relative to said adjacent vertebrae; or fastening said spinal plate to adjacent vertebrae and a mating element comprising engagement portions for mating with said guidance elements relative to the spinal cage.

Targeting chelants and chelates

Novel chelants and other compounds, and compositions thereof are provided, that are useful for detection and treatment of cancer and other abnormal and disease­state cells and tissues.

Deuterated compounds and uses thereof

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

A spinal fixation system

A spinal fixation system, the system including: an alignment 120 assembly comprising: a fastening element; and a mating element configured to receiving the fastening element thereover and having a releasable connector, a 140 fixation assembly comprising: a plate having an aligning aperture that allows 142 the mating element to be received therethrough; and an implant configured to 142- be received between adjacent vertebrae and releasably connect with the releas 14 44 able connector, wherein the fastening element is configured to move along the 2 , 240 mating element to engage with the plate.

Deuterated compounds and uses thereof.

La presente invención proporciona el tratamiento, prevención y/o reducción del riesgo de una enfermedad, trastorno o condición en la que la toxicidad por aldehído está implicada en la patogénesis, incluidos trastornos oculares, trastornos de la piel, condiciones asociadas con efectos perjudiciales de los agentes ampollantes, y enfermedades autoinmunes, inflamatorias, neurológicas y cardiovasculares mediante el uso de una amina primaria para secuestrar aldehídos tóxicos, tales como MDA y HNE.

Confocal wafer inspection method and apparatus using fly lens arrangement

A semiconductor wafer inspection system and method is provided which uses a multiple element arrangement, such as an offset fly lens array. The preferred embodiment uses a laser to transmit light energy toward a beam expander, which expands the light energy to create an illumination field. An offset fly lens array converts light energy from the illumination field into an offset pattern of illumination spots. A lensing arrangement, including a first lens, a transmitter/reflector, an objective, and a Mag tube imparts light energy onto the specimen and passes the light energy toward a pinhole mask. The pinhole mask is mechanically aligned with the offset fly lens array. Light energy passing through each pinhole in the pinhole mask is directed toward a relay lens, which guides light energy onto a sensor. The offset fly lens array corresponds to the pinhole mask. The offset pattern of the offset fly lens array is chosen such that spots produced can be recombined into a continuous image, and the system utilizes a time delay and integration charge coupled device for rapid sensing along with an autofocus system that measures and cancels topological features of the specimen.

Partial credits cashout method

A system or method providing a player an ability to cashout a portion of credits accumulated during gaming. Anonymous cashing out of credit is available to a player through routes both external and internal to a gaming machine.

Nucleotide sequences of maize and soybean β-Ketoacyl-Acyl Carrier Protein Synthase II and their use in the regulation of fatty acid content of oil

Genes encoding β-Ketoacyl-Acyl Carrier Protein Synthase II have been isolated from maize and soybean tissues. These proteins, when expressed in a plant, can alter the saturate levels of the oil.

Insulated wall construction and forms and methods for making same

Deuterated compounds and uses thereof

LA PRESENTE INVENCIÓN PROPORCIONA EL TRATAMIENTO, PREVENCIÓN Y/O REDUCCIÓN DEL RIESGO DE UNA ENFERMEDAD, TRASTORNO O CONDICIÓN EN LA QUE LA TOXICIDAD POR ALDEHÍDO ESTÁ IMPLICADA EN LA PATOGÉNESIS, INCLUIDOS TRASTORNOS OCULARES, TRASTORNOS DE LA PIEL, CONDICIONES ASOCIADAS CON EFECTOS PERJUDICIALES DE LOS AGENTES AMPOLLANTES, Y ENFERMEDADES AUTOINMUNES, INFLAMATORIAS, NEUROLÓGICAS Y CARDIOVASCULARES MEDIANTE EL USO DE UNA AMINA PRIMARIA PARA SECUESTRAR ALDEHÍDOS TÓXICOS, TALES COMO MDA Y HNE THIS INVENTION PROVIDES THE TREATMENT, PREVENTION AND / OR REDUCTION OF THE RISK OF AN ILLNESS, DISORDER OR CONDITION IN WHICH ALDEHYDE TOXICITY IS INVOLVED IN PATHOGENESIS, INCLUDING EYE DISORDERS, SKIN DISORDERS, CONDITIONAL CONDITIONS SPLASHING AGENTS, AND AUTOIMMUNE, INFLAMMATORY, NEUROLOGICAL AND CARDIOVASCULAR DISEASES THROUGH THE USE OF A PRIMARY AMINA TO SEQUEST TOXIC ALDEHYDES, SUCH AS MDA AND HNE

Apparatus for positioning a breast for radiation treatment

The present invention provides a method and apparatus to decrease acute and late skin toxicity for breast cancer patients undergoing radiation therapy. This invention will enable better breast positioning during therapy, eliminating skin folds and reducing the skin dose below that required for development of moist desquamation. The present invention has the potential to reduce the volume of normal tissue and organs at risk of being irradiated during a course of whole breast radiation therapy.