Derivatives of benzosulphonamides as inhibitors of the enzyme cyclo-oxygenase II

DERIVATIVES OF BENZOSULFONAMIDEN AS HEMMER THE ENZYME THE CYCLOOXYGENASE II

SUBSTITUTED DERIVATIVES OF BENZOSULPHONAMIDEN AS HEMMER THE ENZYME THE CYCLOOXYGENASE II

NEW PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS AGENTS LOWERING BLOOD PRESSURE

PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS AGENTS LOWERING BLOOD PRESSURE

Abstract The invention relates to new piperazinylalkyl-3(2H)-pyridazinones of the formula I in which the radicals R1 represents hydrogen, phenyl, benzyl, or (C1-C6)-alkyl which is unsubstituted or substituted one or more times by hydroxyl, piperidine, morpholine or by a group NR4R5 in which R4 and R5 can be identical or different and which represent hydrogen, methyl or ethyl, R2 and R3 represent hydrogen, halogen, (C1-C4)-alkoxy or (C1-C6)-alkyl, where at least one of the radicals R2 or R3 denotes hydrogen, R6 represents hydrogen, (C1-C4)-alkyl, phenyl, benzyl or phenylethyl, B represents (C1-C7)-alkylene which is unsubstituted or substituted one or more times by hydroxyl, (C1-C4)-alkyl or by the group NR4R5 and which can optionally be closed to form an alicyclic 4- to 7-membered ring, R8 and R9, which can be identical or different, represent hydrogen or (C1-C6)-alkyl and Z represents phenyl, naphthyl, pyridyl or thiazolyl, each of which can be unsubstituted or substituted one or more times by (C1-C5)-alkyl, (C1-C5)-alkoxy, benzyloxy, tri-fluoromethyl, halogen, nitro, (C3-C7)-cycloalkoxy, (C1-C4)-alkylthio, trifluoromethylthio or by the group NR4R5, the pharmaceutically utilizable salts thereof, a process for the preparation thereof and the use thereof as medicament for the treatment of hypertension, cardiac insufficiency and disturbances of peripheral circulation.

Substituted derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II

The present application relates to compounds of formula (I) wherein A represents oxygen, sulfur or -NH-, m is 0-2, and R1, R2, R3, R6 and R7 have the meanings given in the specification, to a process for their preparation, as well as to their use in the inhibition of cyclooxygenase II.

Substituted derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase ii

Derivatives of benzosulphonamides as inhibitors of the enzyme cyclo-oxygenase II

PCT No. PCT/EP96/02954 Sec. 371 Date Sep. 3, 1998 Sec. 102(e) Date Sep. 3, 1998 PCT Filed Jul. 5, 1996 PCT Pub. No. WO97/03953 PCT Pub. Date Feb. 6, 1997Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclooxygenase II

DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLOOXYGENASE II

Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclo-oxygenase II.

NEW PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS AGENTS LOWERING BLOOD PRESSURE

SUBSTITUIERTE DERIVATE VON BENZOSULPHONAMIDEN ALS HEMMER DES ENZYM CYCLOOXYGENASE II

DERIVATE VON BENZOSULFONAMIDEN ALS HEMMER DES ENZYM CYCLOOXYGENASE II

VERFAHREN ZUR HERSTELLUNG NEUER PIPERAZINYLALKYL-3(2H)-PYRIDAZINONE

NOVEL PIPERAZINYLALKYL-3(2H)-PIRIDAZINONE, PRODUCTION THEREOF AND USE THEREOF AS AGENTS LOWERING BLOOD PRESSURE

NEW MATERIAL: A compd. represented by formula I R1 is 1-6 alkyl capable of having at least one substituent such as H, phenyl, benzyl, OH, etc.; R2 and R3 are each at least one is H and the other is halogen, 1-6C alkoxy, 1-6C alkyl; R6 is H, 1-4C alkyl, phenyl, benzyl, etc.; B is 1-4C alkylene capable of having at least one substituent such as OH or the like, R8 and R9 are each H or 1-6C alkyl and Z is phenyl, naphthyl, pyridyl, etc., capable of having a substituent such as 1-6C alkoxy or the like) and its salt. EXAMPLE: 2-methyl-4-chloro-5-((2-(4-(2-methoxyphenyl)piperazinyl-1)ethyl)amino)-3(2 H)-pyridazinone. USE: A depressor (a remedy of hypertension, cardiac insufficiency and peripheral circulation disorder). PROCESS: A compd. represented by formula II (M is a discharge group) and a compd. represented by formula III are reacted to obtain the compd. represented by the formula I. COPYRIGHT: (C)1990,JPO ...

Novel piperazinylalkyl-3(2H)-pyridazinones, process for their preparation and their use as hypotensive agents

The invention relates to novel piperazinylalkyl-3(2H)-pyridazinones of the formula <IMAGE> in which R1 is hydrogen, phenyl, benzyl, or (C1-C6)-alkyl which is unsubstituted or mono- or polysubstituted by hydroxyl, piperidine, morpholine or by a group NR4R5 in which R4 and R5 can be identical or different and are hydrogen, methyl or ethyl, R2 and R3 are hydrogen, halogen, (C1-C6)-alkoxy or (C1-C6)-alkyl, where at least one of the radicals R2 or R3 is hydrogen, R6 is hydrogen, (C1-C4)-alkyl, phenyl, benzyl or phenylethyl, B is (C1-C7)-alkylene which is unsubstituted or mono- or polysubstituted by hydroxyl, (C1-C4)-alkyl or by the group NR4R5 and can optionally be closed to give an alicyclic 4- to 7-membered ring, R8 and R9, which can be identical or different, are hydrogen or (C1-C6)-alkyl and Z is phenyl, naphthyl, pyridyl or thiazolyl, unsubstituted or mono- or polysubstituted by (C1-C6)-alkyl, (C1-C6)-alkoxy, benzyloxy, trifluoromethyl, halogen, nitro, (C3-C7)-cycloalkoxy, (C1-C4)-alkylthio, trifluoromethylthio or by the group NR4R5, their pharmaceutically utilisable salts, a process for their preparation and their use as a medicament for the treatment of hypertension, cardiac insufficiency and peripheral circulatory disorders.

Derivatives of benzosulphonamides as inhibitors of the enzyme cyclo-oxygenase ii

Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclo-oxygenase II.

Novel process for the preparation of piperazinylalkyl-3(2h)-pyridazines

BENZOSULFONAMIDE DERIVATIVES AS ENZYME CYCLE-OXYGENASE II INHIBITORS

Saturation of piperazinylalkyl-3 (2H) -pyridazinones or their pharmaceutically acceptable islands

Process for producing new piperazinylalkyl-3/2h/-pyridazinone derivatives and pharmaceutical compositions comprising same

Process for the preparation of new piperazinylalkyl-3(2h)-pyridazinones

Substituierte derivate von benzosulphonamiden als hemmer des enzym cyclooxygenase ii

Derivate von benzosulfonamiden als hemmer des enzym cyclooxygenase ii