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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 8. Отображено 8.
22-04-2009 дата публикации

Penem compounds and preparation thereof

Номер: CN0101412729A
Автор: ZHANG WENJUN, GAN QUANYING, ZHAO JIAO, LIU MIN, LIU DONG, WENJUN ZHANG, QUANYING GAN, JIAO ZHAO, MIN LIU, DONG LIU
Принадлежит:

The invention relates to penem compounds which belong to beta-lactam antibiotics, and a preparation method thereof,. The penem compounds have a structural formula as the right upper formula, wherein R1 is a right lower formula; and R2 is hydrogen, halogen, methyl, a methoxy group, a hydroxyl group, acetyl or nitryl. The penem compounds have multiple action mechanism, can be used for preparing medicines with antibiosis, and have simple and easy operation in the preparation process.

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Номер записи: 1
02-12-2009 дата публикации

1-(3-phenyl acryloyl) piperazine derivatives and preparation method thereof

Номер: CN0101591311A
Автор: ZHANG WENJUN, GAN QUANYING, YANG JING, GUO LEI, WENJUN ZHANG, QUANYING GAN, JING YANG, LEI GUO
Принадлежит:

The invention relates to a series of novel single-aroyl piperazine, in particular to 1-(3-phenyl acryloyl) piperazine derivatives and a preparation method thereof. The compound has a structural formula shown above, wherein R is halogen, methyl, methoxyl, oxhydryl, acetyl or nitryl. The preparation method comprises the following steps: adding anhydrous piperazine in a reactor and then adding glacial acetic acid as a solvent in the reactor; according to the molar ratio of the piperazine to acyl chloride to the glacial acetic acid being 1-2:1:16, dropwise adding the acyl chloride in the reactor; reacting for 1 to 3 hours at a temperature of between 25 and 100 DEG C; after reaction liquid is cooled to room temperature, performing sucking filtration, extraction, drying and rotary evaporation on the obtained product; and recrystallizing the obtained product, and drying the product. The 1-(3-phenyl acryloyl) piperazine derivatives provide more raw materials for medicament synthesis and pesticide ...

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Номер записи: 2
16-07-2008 дата публикации

Method for preparing (3R,4R)-3-[(1R)tert-butyl dimethyl silica ethyl]-4-acetoxy-2-aza ring butanone

Номер: CN0101220050A
Автор: ZHANG WENJUN, ZHAO XIN, WANG YAQIN, GAN QUANYING, FENG JUNLI, WENJUN ZHANG, XIN ZHAO, YAQIN WANG, QUANYING GAN, JUNLI FENG
Принадлежит:

The invention discloses a method for preparation of (3R, 4R) -3-[(1R)-(tert-butyl dimethylsilyloxy) ethyl]-4-acetoxy-2-azetidinone. The method contains procedures such as diazotization, bromination, esterification, Griganard reaction, reduction, hydroxyl protection, ring opening, oxidation, etc., wherein through reaction time adjustment during the process of esterification, reaction temperature decrease in ring opening and application of pyridine as the solvent in synthesis of (3S, 5R, 6S)-6-bromine-6-[(1R)-hydroxyethyl] penicillanic acid methyl ester of the Griganard reaction, the reaction of procedure 3) can be carried out ranging from minus 25 DEG C to minus 5 DEG C with equivalent total yield, thereby greatly reducing the equipment investment and energy consumption.

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Номер записи: 3
22-04-2009 дата публикации

Duloxetine derivative and preparation thereof

Номер: CN0101412707A
Автор: ZHANG WENJUN, GAN QUANYING, LIU MIN, ZHAO JIAO, LIU DONG, WENJUN ZHANG, QUANYING GAN, MIN LIU, JIAO ZHAO, DONG LIU
Принадлежит:

The invention relates to a duloxetine derivative and a method for preparing the same, which belongs to the chemistry field of medicine with antidepressant activity. The structural formula is as shown in the right formula, wherein R is aryl radical or tertiary butyl. The method for preparing the duloxetine derivative comprises the following steps: dissolving duloxetine in dichloromethane; adding an acid-binding agent into the mixture of which the mol ratio of the duloxetine to the acid-binding agent is between 1 to 1.5 and 1 to 3; stirring the mixture at room temperature for 20 minutes, and then dripping acyl chloride into the mixture of which the molar ratio of the duloxetine to the acyl chloride is between 1 to 1.2 and 1 to 2; reacting the mixture at a temperature of between 0 and 30 DEG C for 1 to 5 hours to obtain the duloxetine derivative, wherein the acid-binding agent is N, N-diisopropyl ethyl amine, pyridine or triethylamine, and the acyl chloride is aryl acyl chloride or pivalyl ...

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Номер записи: 4
09-06-2010 дата публикации

Method for preparing (3R,4R)-3-[(1R)tert-butyl dimethyl silica ethyl]-4-acetoxy-2-aza ring butanone

Номер: CN0101220050B
Автор: ZHAO XIN, ZHANG WENJUN, FENG JUNLI, GAN QUANYING, WANG YAQIN, XIN ZHAO, WENJUN ZHANG, JUNLI FENG, QUANYING GAN, YAQIN WANG
Принадлежит:

The invention discloses a preparation method of (3R, 4R) -3-[(1R) tert-butyl dimethylsilyloxy ethyl]-4-acetoxy-2-azetidinone. The method includes the procedures such as diazotization, bromination, esterification, Griganard reaction, reduction, hydroxyl protection, ring opening, oxidation, etc.; wherein through reaction time adjustment during the process of esterification, the reaction temperatureis decreased in the ring opening and the application of pyridine as the solvent in the synthesis of (3S, 5R, 6S)-6-bromine-6-[(1R)-hydroxyethyl] penicillanic acid methyl ester of the Griganard procedure, the reaction of procedure 3) can be carried out ranging from minus 25 DEG C to minus 5 DEG C with equivalent total yield, thereby greatly reducing the equipment investment and energy consumption.

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Номер записи: 5
16-12-2009 дата публикации

Zeolite single-layer film and preparation method thereof

Номер: CN0101601973A
Автор: LI HUANRONG, WANG YU, FENG YU, WANG YIGE, GAN QUANYING, CHEN YUHUAN, ZHANG YING, HUANRONG LI, YU WANG, YU FENG, YIGE WANG, QUANYING GAN, YUHUAN CHEN, YING ZHANG
Принадлежит:

The invention provides a zeolite single-layer film and a preparation method thereof, and relates to a semitransparent film using an inorganic material as feature. The zeolite single-layer film is a luminous c-axis orientated L-shaped zeolite single-layer film, and consists of a carrier, a luminous molecule connector and zeolite; and the luminous molecule connector which is easy to form covalent bonds with zeolite crystal and the carrier is designed and directionally synthesized with the L-shaped zeolite and the carrier to realize c-axis orientation and realize supermolecular assembly of rare-earth organic complex guest molecules in the single-layer film so as to obtain the single-layer film of the luminous c-axis orientated L-shaped zeolite. The product can fill dye molecules into conduits of the L-shaped zeolite crystal to form a system which can carry out photochemical conversion and store solar energy, and is used for preparing a photoelectric cell and a high three-dimensional resolution ...

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Номер записи: 6
22-04-2009 дата публикации

Duloxetine derivative and preparation thereof

Номер: CN0101412708A
Автор: ZHANG WENJUN, GAN QUANYING, LIU MIN, ZHAO JIAO, LIU DONG, WENJUN ZHANG, QUANYING GAN, MIN LIU, JIAO ZHAO, DONG LIU
Принадлежит:

The invention relates to a duloxetine derivative and a method for preparing the same, which belongs to the chemistry field of medicine with antidepressant activity. The structural formula is as shown in the right formula, wherein R is aryl radical or tertiary butyl. The method for preparing the duloxetine derivative comprises the following steps: step one, dissolving duloxetine in dichloromethane in a reactor, adding an acid-binding agent into the mixture, stirring the mixture at room temperature for 20 minutes, and then dripping chloroacetic chloride into the mixture to react at a temperature of between 0 and 30 DEG C for 1 to 5 hours to generate an amide compound 1; and step two, dissolving the amide compound 1 generated in the step one in acetonitrile in the reactor, adding sodium iodide and triethylamine into the mixture of which the mol ratio of the amide compound 1 to the odium iodide to the triethylamine is 1 to 0.003 to (1.5 to 3), and then adding a piperazine compound into the ...

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Номер записи: 7
22-04-2009 дата публикации

3-acryloyl chloride derivative and preparation thereof

Номер: CN0101412668A
Автор: ZHANG WENJUN, GAN QUANYING, ZHAO JIAO, LIU MIN, LIU DONG, WENJUN ZHANG, QUANYING GAN, JIAO ZHAO, MIN LIU, DONG LIU
Принадлежит:

The invention relates to 3-phenyl acryloyl chloride derivative and a preparation method thereof. The 3-phenyl acryloyl chloride derivative belongs to a series of novel acyl chloride, which has a structural formula as right, wherein R is halogen, methyl, methoxyl, hydroxyl, acetyl or nitryl. The preparation method for the 3-phenyl acryloyl chloride derivative comprises the following steps: adding carboxylic acid and N, N-dimethyl formamide into a reactor, using methyl benzene as a solvent, and adding thionyl chloride into the reactor to react for 1 to 3 hours at a temperature of between 25 and 100 DEG C to obtain the acyl chloride through vacuum rotary steaming and distillation under reduced pressure in an oil pump, wherein the molar ratio of the added carboxylic acid to the DMF (dimethyl formamide) to the methyl benzene to the thionyl chloride is 1 to 0.01 to 15 to 1-2. The 3-phenyl acryloyl chloride derivative provides more raw materials for organic synthesis and pharmaceutical synthesis ...

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Номер записи: 8