24-03-2016 дата публикации
Номер: US20160083383A1
Автор:
Guo Lei,
Hu Taishan,
Kou Buyu,
Lin Xianfeng,
Shen Hong,
Shi Houguang,
Yan Shixiang,
ZHANG WEIXING,
Zhang Zhisen,
Zhou Mingwei,
Zhu Wei
The invention provides novel compounds having the general formula: 2. A compound according to claim 1 , wherein{'sup': '1', 'Ris hydrogen, chloro, bromo or methyl;'}{'sup': '2', 'Ris hydrogen or fluoro;'}{'sup': '3', 'Ris hydrogen, chloro or fluoro;'}{'sup': '4', 'Ris methyl, ethyl or propyl;'}{'sup': '5', 'Ris hydrogen, hydroxymethyl, aminocarbonyl, methoxycarbonyl or carboxy;'}{'sup': '6', 'Ris hydrogen, methyl-O-carbonyl or carboxymethyl;'}X is carbonyl or sulfonyl;{'sub': '2', 'sup': '7', 'claim-text': {'sup': '7', 'wherein Ris hydrogen, methyl, difluoroethyl, isopropyl, isobutyl, t-butyl, cyclopropyl, cyclopropylmethyl, methyl-O-carbonylisopropyl, carboxyethyl, carboxydifluoroethyl, carboxypropyl, carboxybutyl, carboxy(gemdimethyl)methyl, carboxy(gemdimethyl)ethyl, carboxy(gemdimethyl)propyl, carboxy(gemdimethyl)butyl, carboxy(methyl)ethyl, carboxy(ethyl)ethyl, carboxy(methoxy)ethyl, carboxycyclobutyl, carboxycyclobutylmethyl, carboxycyclopentyl, carboxycyclohexyl, carboxymethylcyclopropyl, carboxycyclopropylmethyl, carboxycyclobutylmethyl, carboxyspiro[3.3]heptyl, carboxymethoxyethyl, carboxymethoxypropyl, hydroxyethyl, hydroxymethyl(gemdimethyl)butyl, hydroxy(gemdimethyl)ethyl, carboxyphenyl, carboxypyridinyl or carboxyphenylmethyl;'}, 'Y is —CH—, —O—, —N(R)—,'}{'sub': 2', '3', '2, 'W is —CH—, —C(CH)—, —O— or carbonyl; and'}n is 0 or 1;or a pharmaceutically acceptable salt, enantiomer, or diastereomer thereof.4. A compound according to or a pharmaceutically acceptable salt claim 1 , enantiomer claim 1 , or diastereomer thereof claim 1 , wherein{'sup': '1', 'Ris chloro, bromo or methyl;'}{'sup': '2', 'Ris hydrogen or fluoro;'}{'sup': '3', 'Ris hydrogen, chloro or fluoro;'}{'sup': '4', 'Ris methyl, ethyl or propyl;'}{'sup': '5', 'Ris hydrogen, hydroxymethyl, aminocarbonyl, methoxycarbonyl or carboxy;'}{'sup': '6', 'Ris hydrogen, methyl-O-carbonyl or carboxymethyl;'}{'sup': '7', 'claim-text': {'sup': '7', 'wherein Ris hydrogen, methyl, difluoroethyl, isopropyl, ...
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