TRANSPARENTE ELEKTRODE BASIEREND AUF EINER KOMBINATION TRANSPARENTER LEITENDER OXIDE, METALLE UND OXIDE

Die Erfindung betrifft eine Elektrode, umfassend ein transparentes leitendes Oxid (TCO) und einen ultradünnen Metallfilm (UTMF), der auf dem TCO aufgebracht ist. Außerdem ist der UTMF oxidiert oder von einer Oxidschicht bedeckt. Auf diese Weise ist das darunter liegende TCO geschützt/kompatibel mit anderen Materialien und der Verlust an Transparenz ist reduziert.

PROCESS AND SYSTEM TO DETECT MATTER DEFECTS IN PADDLES OF ROTOR OF ENGINES HAVE TURBINE HAS COMBUSTION

Le système comporte : une aube (126) de rotor de turbine pourvue d'un revêtement isolant ; une première électrode (134) électriquement connectée à l'aube (126) de rotor de turbine ; une seconde électrode (135) située à proximité de l'aube (126) de rotor de turbine ; un moyen pour appliquer une tension sur la première électrode (134) et la seconde électrode (135) ; et un moyen pour détecter un courant passant entre la première électrode (134) et la seconde électrode (135).

PROCESS AND SYSTEM TO DETECT MATTER DEFECTS IN THE ENGINES HAVE TURBINE HAS COMBUSTION.

Système pour détecter des défauts dans un conduit de combustion d'un système de combustion d'un moteur à turbine à combustion pendant le fonctionnement du moteur à turbine à combustion, le conduit de combustion comportant un côté chaud, qui est exposé à des gaz de combustion et, à l'opposé du côté chaud, un côté froid. Le système peut comporter : un revêtement témoin (163) disposé sur une surface extérieure du conduit de combustion, le revêtement témoin (163) étant constitué par une substance détectable ; et un détecteur de gaz installé en aval du système de combustion, le détecteur de gaz étant conçu pour réaliser une mesure de la quantité de substance détectable dans les produits de combustion du moteur à turbine à combustion.

PROCESS AND SYSTEM TO DETECT MATTER DEFECTS IN DEVICES OF COMBUSTION OF ENGINES HAVE TURBINE HAS COMBUSTION

Procédé pour détecter des défauts dans un conduit de combustion (148) dans un système de combustion d'un moteur à turbine pendant le fonctionnement du moteur à turbine, le conduit de combustion ayant une surface interne qui, pendant la marche, est exposée à la veine de gaz chauds, le procédé comportant les étapes de installation d'une première électrode (163) électriquement connectée au conduit de combustion (148) ; installation d'une seconde électrode (164) située dans la veine de gaz chauds ; application d'une tension sur la première électrode (163) et la seconde électrode (164) et détection d'un courant passant entre la première électrode (163) et la seconde électrode (164).

PROCESS AND APPARATUS OF SEARCH FOR POSITION IN A COMMUNICATION SYSTEM

PROCESS AND SYSTEM TO DETECT MATTER DEFECTS IN THE ENGINES HAVE TURBINE HAS COMBUSTION.

Système pour détecter des défauts dans un conduit de combustion d'un système de combustion d'un moteur à turbine à combustion pendant le fonctionnement du moteur à turbine à combustion, le conduit de combustion comportant un côté chaud, qui est exposé à des gaz de combustion et, à l'opposé du côté chaud, un côté froid. Le système peut comporter : un revêtement témoin (163) disposé sur le côté froid du conduit de combustion, et un détecteur de proximité disposé tout près du conduit de combustion et conçu pour détecter une distance entre l'emplacement du détecteur de proximité et le côté froid du conduit de combustion.

METHOD AND SYSTEM FOR DETECTING DEFECTS OF MATERIAL INTO THE COMBUSTION TURBINE ENGINES.

METHOD AND SYSTEM FOR DETECTING DEFECTS MATERIAL IN PLANTS FOR THE COMBUSTION OF COMBUSTION TURBINE ENGINES

PROCESS AND DEVICE FOR the DETERMINATION Of a POSITION IN a MULTIPLE SYSTEM AACCES HAVE DIVISION BY CODE (CDMA)

ACTIVE FILTERING SYSTEM

L'invention concerne un système de filtrage actif (AF) agencé pour se connecter entre une première ligne d'alimentation (10) et une deuxième ligne d'alimentation (11) d'un bus continu, ledit bus étant agencé pour être connecté à une source de tension continue située en amont, ledit système comportant : Un premier condensateur (C1) agencé pour se connecter d'une part à la première ligne d'alimentation du bus (10) et d'autre part à la deuxième ligne d'alimentation (11) du bus et aux bornes duquel est appliquée une tension (VC1) comprenant une composante alternative (VC1), Un ensemble de commutation (SW) commandé par des moyens de traitement (UC) pour générer une tension de compensation (VAF), en opposition de la composante alternative (VC1) de la tension aux bornes du premier condensateur (C1), et comprenant une première borne (B1) connectée au premier condensateur (C1) et une deuxième borne (B2) destinée à se connecter à la deuxième ligne d'alimentation (11).

Digital image processing for medical imagery, comprises segmenting the data unit of image, generating a projection with maximum intensity of the segmented data unit, rebuilding the data unit and combining the results

Procédé de traitement d'image numérique, comprenant les étapes consistant à (i) segmenter un ensemble de données d'une image à traiter, en fonction de conditions prédéterminées ; (ii) générer une projection à intensité maximale de l'ensemble de données segmenté ; (iii) fermer par reconstruction ledit ensemble de données parallèlement à l'étape (ii) ; (iv) combiner le résultat de l'étape (i) avec le résultat de l'étape (iii) par une fonction logique ET, et (v) remplacer les pixels d'intensité non voulue dans le résultat de l'étape (ii) par des pixels d'intensité voulue à partir du résultat de l'étape (iv).

PROCESS AND SYSTEM TO DETECT MATTER DEFECTS IN THE ENGINES HAVE TURBINE HAS COMBUSTION.

Système pour détecter des défauts dans un conduit de combustion d'un système de combustion d'un moteur à turbine à combustion pendant le fonctionnement du moteur à turbine à combustion, le conduit de combustion comportant un côté chaud, qui est exposé à des gaz de combustion et, à l'opposé du côté chaud, un côté froid. Dans une forme de réalisation, le système comporte : un photodétecteur (165) orienté vers le côté froid du conduit de combustion, le photodétecteur (165) étant conçu pour détecter un changement visible sur le côté froid du conduit de combustion.

TOPICAL KETOCONAZOLE LIDOCAINE AND FATTY ACID USEFUL AS AN ANALGESIC, ANALGESIC OR DELAYING SEXUAL

La présente invention concerne une émulsion huile-dans-eau constituée d'eau et d'une phase huileuse constituée de lidocaïne, d'un premier acide gras, d'un second acide gras, le premier acide gras étant l'acide laurique et/ou l'acide tridécanoïque, le second acide gras étant choisi parmi l'acide mystirique, l'acide palmitique, l'acide stéarique et l'acide oléique, et leurs mélanges. Ces émulsions sont utiles en tant que médicament, notamment en tant qu'analgésique, antalgique chez l'homme ou l'animal, ou retardant sexuel. Elles peuvent être incorporées dans une composition pharmaceutique ou vétérinaire, ou dans un dispositif médical.

ÖKOLOGISCHES VERFAHREN ZUR HERSTELLUNG VON BROMBENZOL

METHOD AND SYSTEM FOR DETECTING DEFECTS IN MATERIAL OF ROTOR BLADES IN A COMBUSTION TURBINE ENGINES

PRODUKTLECKPRÜFUNG

Material del letrero imprimible que comprende arandelas delgadas aplicadas a este antes de introducirlo a un dispositivo de impresion antes de la introduccion a un dispositivo de impresion, las arandelas son lo suficientemente delgadas para alimentarse en el dispositivo de impresion; y metodo para producir letreros impresos con arandelas.

Material del letrero imprimible que comprende arandelas delgadas aplicadas a este antes de introducirlo a un dispositivo de impresión antes de la introducción a un dispositivo de impresión, las arandelas son lo suficientemente delgadas para alimentarse en el dispositivo de impresión; y método para producir letreros impresos con arandelas.

ALPHA-KETOAMIDE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS

The present invention is directed to α-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders. 12. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of .13. A pharmaceutical composition made by mixing a compound of and a pharmaceutically acceptable carrier.14. A process for making a pharmaceutical composition comprising mixing a compound of and a pharmaceutically acceptable carrier.15. A method of treating a disorder mediated by the endothelial lipase claim 1 , comprising administering to a subject in need thereof a therapeutically effective amount of the compound of .16. The method of claim 15 , wherein the disorder mediated by the endothelial lipase is selected from the group consisting of atherosclerosis claim 15 , dyslipidemia claim 15 , low HDL and high LDL.17. A method of treating a disorder selected from the group consisting of atherosclerosis claim 12 , dyslipidemia claim 12 , low HDL and high LDL comprising administering to the subject in need thereof a therapeutically effective amount of the composition of .18. A method of treating a condition selected from the group consisting of atherosclerosis claim 1 , dyslipidemia claim 1 , low HDL and high LDL comprising administering to the subject in need thereof a therapeutically effective amount of the compound of .19. The use of a compound as in for the preparation of a medicament for treating: (a) atherosclerosis claim 1 , (b) dyslipidemia claim 1 , (c) low HDL or (d) high LDL claim 1 , in a subject in need thereof. trifluoromethyl-phenyl claim 1 , This application claims the benefit of U.S. Provisional Application 61/386,671, filed on Sep. 27, 2010, which is incorporated by reference herein in its entirety.The present invention is directed to α-ketoamide derivatives, pharmaceutical compositions containing them and their use in ...

User-Defined Parallelization in Transactional Replication of In-Memory Database

A replication track is a designated group of transactions that are to be replicated at a destination database in a way that, with respect to any other transaction in the replication track, preserves transactional dependency. Further, transactions in a replication track can be replicated at the destination database without regard to transactional dependency of other transactions in another track. This facilitates concurrent parallel replication of transactions of different tracks. Replicating data in this manner is referred to herein as track replication. An application may request execution of transactions and designate different tracks for transactions. 1. A method comprising steps of:a first database server executing a first plurality of transactions, said first plurality of transactions including one or more database changes to a database managed by said first database server, wherein said first plurality of transactions are executed by said first database server in response to requests received by said database server from a set of application clients;said first database server assigning each transaction of said first plurality of transactions to a track of a plurality of tracks;while said first database server is executing said first plurality of transactions, each track of said plurality of tracks is associated with only one physical track of a plurality of physical tracks;for the respective transactions assigned each track of said plurality of tracks, said first database server causing the respective transactions to be replicated at a destination database server via only one physical track of said plurality of physical tracks; replicated at said destination database server in a way that accounts for transactional dependency of any transaction replicated via said each physical track;', 'replicated at said destination database server in a way that ignores transactional dependency of any transaction replicated via any other physical track of said plurality of ...

AUTOMATED INTEGRATED HIGH AVAILABILITY OF THE IN-MEMORY DATABASE CACHE AND THE BACKEND ENTERPRISE DATABASE

A cluster manager manages copies of a mid-tier database as a mid-tier database cluster. The cluster manager may concurrently manage a backend database system. The cluster manager is configured to monitor for and react to failures of mid-tier database nodes. The cluster manager may react to a mid-tier database failure by, for example, assigning a new active node, creating a new standby node, creating new copies of the mid-tier databases, implementing new replication or backup schemes, reassigning the node's virtual address to another node, or relocating applications that were directly linked to the mid-tier database to another host. Each node or an associated agent may configure the cluster manager during initialization, based on common cluster configuration information. Each copy of the mid-tier database may be, for example, a memory resident database. Thus, a node must reload the entire database into memory to recover a copy of the database. 1. A method comprising:at a first node, storing a first database comprising a first set of data; wherein the first instance of the application provides, to a client, services that involve transactions with the first database;', 'wherein the first instance of the application depends upon the first database to provide said services;, 'at the first node, executing a first instance of an application;'} wherein the second database stores a copy of the first set of data;', 'wherein the second instance of the application executes at a second node that is different than the first node;, 'responsive to detecting that the first database is no longer accessible at the first node, causing the client to be redirected to a second instance of the application for provision of services that involve transactions with a second database;'}wherein the method is performed by one or more computing devices.2. The method of claim 1 , wherein causing the client to be redirected to the second instance comprises starting the second instance of the ...

Packaged RFID Passive Tag for Small Sized Devices

The present application is related to a unique transponder clip comprising a UHF passive RFID tag, an encapsulation module and method of attaching the encapsulation module enclosing the transponder clip to small sized devices. In an aspect, the small sized device may be a small sized medical device such as bone screw, spine screw implants. The transponder is enclosed in the encapsulation module that is then attached to a small sized device thereby facilitating auto-identification and tracking of the small sized device.

Laser architectures

Disclosed herein are architectures for VCSEL systems. By using high power IR VCSEL element(s), a bulk doubling material can be used to double the IR light and generate visible light (red, green, blue, or UV light) in a cavity, in either continuous wave (CW) or pulsed mode. The reflectivity of the output distributed Bragg reflector (DBR) of these VCSELs can be designed to increase the power in the cavity, rather than the power in the VCSEL laser. By enabling the use of a bulk doubling material in the cavity and directly doubling the VCSEL the device can be inexpensive, simpler, high efficiency, better reliability, and vastly improved manufacturing and alignment tolerances. There are a number of cavity architectures that can be used to double the IR light from the VCSEL(s). The VCSEL(s) can be single elements, or arrays with high intensity elements.

Coated tablet formulations and uses thereof

The present invention provides coated tablet formulations comprising neratinib maleate, and improved methods for making such coated tablets.

Methylation markers and targeted methylation probe panel

The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns. Further provided herein includes methods of designing, making, and using the cancer assay panel for diagnosis of cancer.

Methods and compositions for the treatment of seizure-related disorders

Compositions and methods are provided for administering a pharmaceutical composition to a human patient. Compositions are administered to a human patient orally, once daily, at a therapeutically effective dose. The pharmaceutical compositions comprise a drug selected from the group consisting of brivaracetam, divalproex, lacosamide, levetiracetam, oxcarbazepine, vigabatrin, and pharmaceutically acceptable salts of any of the foregoing, and at least one excipient. At least one of said at least one excipients modifies the release of said drug to provide an extended release form. The pharmaceutical composition have pharmacokinetic properties recited in the claims.

Method and system for performing summarization of text

In an embodiment, a method of performing summarization of text is disclosed. The method may include receiving an input text including a plurality of paragraphs and a user-query including one or more tokens. The method may further include segregating the input text into the plurality of paragraphs, creating a plurality of paragraph-vectors representative of the plurality of paragraphs, and clustering the plurality of paragraph-vectors to generate one or more clusters of paragraph-vectors. The method may further include determining a relevant cluster of paragraph-vectors from the one or more clusters of paragraph-vectors, based on a degree of similarity of each cluster of paragraph-vectors with the user-query. The relevant cluster of paragraph-vectors is representative of a set of relevant paragraphs from the input text. The set of relevant paragraphs corresponding to the relevant cluster of paragraph-vectors may be outputted.

Low voltage tolerant ultra-low power edge triggered flip-flop for standard cell library

A method and a flip-flop for designing low power integrated circuits (IC's). The method includes receiving at least one of a clock signal, a data signal, and a complimentary data signal. The complimentary data signal is produced by an input data inverter present in the flip-flop. Further, the method includes generating at least one master internal signal based on the received at least one of the clock signal, the data signal, and the complimentary data signal, when the clock signal is at a low logic level. Further, the method includes generating at least one slave internal signal based on at least one of the received clock signal and the generated at least one master internal signal, when the clock signal is at a high logic level. Further, the method includes generating an output signal based on the generated at least one slave internal signal.

Heterocyclic compounds as protein kinase inhibitors

The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A′ B, D, R 1 , R 2 and R 3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

AUTOMATIC PROFILING OF APPLICATION WORKLOADS IN A PERFORMANCE MONITORING UNIT USING HARDWARE TELEMETRY

A performance monitoring unit of a processor includes one or more performance monitoring counters, and a behavioral detector to sample data from a set of the one or more performance monitoring counters, analyze the sampled data, and identify a type of workload of a software process being executed by the processor. 1. A processor comprising:one or more processing cores, and one or more performance monitoring counters; and', 'a behavioral detector to sample data from a set of the one or more performance monitoring counters, analyze the sampled data, and identify a type of workload of a software process being executed by the processor., 'a performance monitoring unit (PMU), the PMU including'}2. The processor of claim 1 , comprising an intellectual property (IP) block including a machine learning process to analyze the sampled data and identify the type of workload of the software process being executed by the processor.3. The processor of claim 2 , wherein the PMU comprises:one or more configuration model specific registers (MSRs); anda behavioral detector manager to read a configuration MSR associated with the behavioral detector and to activate the behavioral detector when the configuration MSR is set.4. The processor of claim 3 , wherein the behavioral detector manager is to update a runtime MSR associated with the behavioral detector to indicate the type of workload of the software process is identified.5. The processor of claim 3 , wherein the behavioral detector manager to determine if the set of the one or more performance monitoring counters are available and assign the set of the one or more performance monitoring counters to the behavioral detector when available.6. The processor of claim 5 , wherein the behavioral detector manager is to program the assigned set of the one or more performance monitoring counters to record data relating to events needed by the behavioral detector to identify the workload.7. The processor of claim 5 , wherein the PMU comprises ...

PROGRAMMABLE PERFORMANCE MONITORING UNIT SUPPORTING SOFTWARE-DEFINED PERFORMANCE MONITORING EVENTS

A processor includes one or more processing cores, and a performance monitoring unit (PMU), the PMU including one or more performance monitoring counters; a PMU memory to store a PMU kernel, the PMU kernel including one or more programmable PMU functions; and a PMU processor to load the PMU kernel and concurrently execute the one or more programmable PMU functions of the PMU kernel to concurrently access the one or more performance counters. 1. A processor comprising:one or more processing cores, and one or more performance monitoring counters;', 'a PMU memory to store a PMU kernel, the PMU kernel including one or more programmable PMU functions; and', 'a PMU processor to load the PMU kernel and concurrently execute the one or more programmable PMU functions of the PMU kernel to concurrently access the one or more performance monitoring counters., 'a performance monitoring unit (PMU), the PMU including'}2. The processor of claim 1 , wherein one of the one or more programmable PMU functions uses non-PMU telemetry data of the processor.3. The processor of claim 1 , wherein at least one of the one or more programmable PMU functions includes specification of one or more PMU events.4. The processor of claim 3 , wherein the one or more PMU events includes data from at least one performance monitoring counter.5. The processor of claim 3 , wherein the one or more PMU events comprises an event defined by a software (SW) driver executed by the processor.6. The processor of claim 1 , wherein the one or more programmable PMU functions are received by the PMU from one or more SW drivers being executed by the processor.7. The processor of claim 6 , wherein the one or more programmable PMU functions claim 6 , when concurrently executed claim 6 , concurrently write data to one or more buffers in the processor and the one or more SW drivers read data from the one or more buffers.8. The processor of claim 1 , wherein the PMU kernel is received by the PMU from a PMU driver being ...

PERFORMANCE MONITORING UNIT OF A PROCESSOR DETERRING TAMPERING OF COUNTER CONFIGURATION AND ENABLING VERIFIABLE DATA SAMPLING

A secure performance monitoring unit of a processor includes one or more performance monitoring counters and a secure group manager. The secure group manager is configured to receive a request to create a secure counter group from a software (SW) process being executed by a processor, the request including identification of the one or more counters; determine availability of the one or more counters, creating the secure counter group, assign the one or more counters to the secure counter group, and save a public key of the SW process, when the one or more counters are available; receive and save a private key for the secure counter group; receive a request to configure the secure counter group from the SW process; verify the configuration using the public key of the SW process; and begin sampling of the one or more counters when the configuration is verified. 1. An apparatus comprising:one or more performance monitoring counters; and{'claim-text': ['receive a request to create a secure counter group from a software (SW) process being executed by a processor, the request including identification of the one or more performance monitoring counters;', 'determine availability of the one or more performance monitoring counters, creating the secure counter group, assign the one or more performance monitoring counters to the secure counter group, and save a public key of the SW process, when the one or more performance monitoring counters are available;', 'receive and save a private key for the secure counter group;', 'receive a request to configure the secure counter group from the SW process;', 'verify the configuration using the public key of the SW process; and', 'start sampling of the one or more performance monitoring counters when the configuration is verified.'], '#text': 'a secure group manager to'}2. The apparatus of claim 1 , comprising:one or more counter model specific registers (MSRs); andone or more signature MSRs;wherein the secure group manager to, for a ...

Methods of treating congenital adrenal hyperplasia

Patients with congenital adrenal hyperplasia (CAH) need adequate care and treatment in order to lead normal lives. Hence, there is a need for new methods of treating CAH. This disclosure provides new compounds, salts, compositions and uses thereof in the treatment of CAH.

True single-phase clock (tspc) nand-based reset flip-flop

A True Single-Phase Clock (TSPC) NAND-based reset flip-flop includes a reset functionality to perform a reset operation. The flip-flop with the reset functionality includes a master section and a slave section. The reset functionality is achieved using two transistors in the master section. The master section and the slave section operate using the TSPC. The master section and the slave section may include a plurality of NAND circuits and a NAND and NOR circuit for performing the reset operation. The master section outputs a plurality of internal signals on receiving a data input, a scan enable signal, a scan input signal, a reset control signal, and a clock signal. The slave section generates an output on receiving the plurality of internal signals received from the master section.

SURGICAL TOOL AND ROBOTIC SYSTEM COMPRISING SUCH A SURGICAL TOOL

Surgical tools and robotic systems adaptable for treating a left side or a right side of a patient with minimal interference with the patient and surrounding operative site are disclosed. In some embodiments, a surgical tool can include a body, an end-effector, a first connector, a second connector, and a third connector. The end-effector can extend from a distal end of the body and be movable relative to the body about a pivot axis. The first connector can rigidly secure the body to a planar mechanism. The second and third connectors can rigidly secure a distal part and a proximal part of a tracker, respectively, to the body. The first and second connectors can be symmetrical to each other with respect to a plane including a longitudinal axis of the body and the pivot axis and can be suited for attachment of either the tracker or the planar mechanism. 1. A surgical tool comprising:a body defining a longitudinal axis,an end-effector extending from a distal end of the body, the end-effector being movable relative to the body about a pivot axis,a first connector configured to rigidly secure the body to a planar mechanism,a second connector configured to rigidly secure a distal part of a tracker to the body,wherein the first and second connectors are symmetrical to each other with respect to a plane comprising the longitudinal axis and the pivot axis and are suited for attachment of either the tracker or the planar mechanism, anda third connector configured to rigidly secure a proximal part of the tracker to the body.2. The surgical tool according to claim 1 , wherein the body comprises a recess shaped to receive a user's palm.3. The surgical tool according to claim 1 , further comprising a handle selectively pivotable relative to the body claim 1 , the handle comprising a grip and a trigger configured to activate the end-effector.4. The surgical tool according to claim 3 , wherein the handle is selectively pivotable about an axis orthogonal to the longitudinal axis.5. ...

PREVENTING FACE-BASED AUTHENTICATION SPOOFING

System and techniques for preventing face-based authentication spoofing are described herein. A visible light emitter may be controlled to project a pattern into a camera's field of view during an authentication attempt. An image may be obtained from the camera for the authentication attempt. A potential spoofing region on image may be identified by finding the pattern. An authentication attempt based on a face found in the potential spoofing region may be prevented. 1. A system to prevent face-based authentication spoofing , the system comprising:an emitter controller to control a visible light emitter to project a pattern into a field of view for a camera during an authentication attempt using a face;an image sampler to obtain an image from the camera for the authentication attempt; and identify a potential spoofing region of the image by finding the pattern within predetermined tolerances in the image; and', 'prevent the authentication attempt based on a face found in the potential spoofing region., 'a spoofing detection controller to2. The system of claim 1 , wherein the pattern is moving.3. The system of claim 1 , wherein the pattern includes a foreground and a background.4. The system of claim 3 , wherein the background is selected to illuminate the face for the authentication attempt.5. The system of claim 1 , comprising a library controller to:receive a user submitted pattern; andtest the user submitted pattern to determine whether it has features to distinguish it from organic features.6. The system of claim 5 , wherein the spoofing controller is arranged to include the user submitted pattern in a library of patterns when it does have features to distinguish the user submitted pattern from organic features claim 5 , and rejecting the user submitted pattern otherwise.7. The system of claim 5 , wherein the library controller is arranged to:add features that are distinguishable from organic features to the user submitted pattern to create a modified user ...

3D ENHANCED IMAGE CORRECTION

A user authentication system and method. A two-dimensional image of a scene is obtained and range information obtained from the scene is aligned with the two-dimensional image. One or more depth regions is identified and image segments corresponding to the one or more depth regions are selected within the two-dimensional image. Brightness operations are performed on one or more of the selected image segments to form a corrected image. 1. A system for enhanced image correction , comprising:a 2D camera;a 3D camera; and receive a two-dimensional image from the 2D camera;', 'receive range information from the 3D camera;', 'align the range information with the two-dimensional image;', 'identify one or more depth regions;', 'select, within the two-dimensional image, image segments corresponding to the one or more depth regions;', 'perform brightness operations on one or more of the image segments to form a corrected image; and', 'authenticate a user based on a user feature in the corrected image., 'a processor to2. The system of claim 1 , wherein the two-dimensional image is a video frame.3. The system of claim 1 , wherein to select image segments claim 1 , the processor is to generate a pixel polygon descriptor for each image segment.4. The system of claim 1 , wherein to align the range information with the two-dimensional image claim 1 , the processor is to convert the range information to a coordinate system.5. The system of claim 1 , wherein the range information is segmented based on world coordinate contours.6. The system of claim 1 , wherein to select the image segment claim 1 , the processor is to project the depth region on the two-dimensional image.7. The system of claim 1 , wherein the processor is to determine claim 1 , for each selected image segment claim 1 , a desired pixel brightness in the hue saturation brightness space and modifies 2D camera controls as necessary to achieve the desired pixel brightness in the hue saturation brightness space.8. The ...

Patterning line cuts before line patterning using sacrificial fill material

A method includes forming a dielectric layer on a semiconductor substrate, forming a hard mask layer on the dielectric layer, forming a sacrificial mandrel layer on the hard mask layer, depositing a sacrificial fill material in an opening in the sacrificial mandrel layer and utilizing the sacrificial fill material to selectively pattern the hard mask layer. The pattern defining first and second spaced openings in the hard mask layer. The method further includes etching the dielectric layer through the first and second openings in the hard mask layer to create first and second trenches in the dielectric layer separated by a dielectric segment of the dielectric layer.

Blue Fluorescent Protein and Methods of Use Thereof

This invention provides methods of making and using a fluorescent probe from the Sandercyanin protein as set forth in SEQ ID NO: 1 or SEQ ID NO: 2. In one embodiment, the invention provides a method of creating a fluorescent probe, comprising the steps of attaching a Sandercyanin moiety to a probe, wherein the probe is specific to a desired target.

System and method for forecasting power output of a wind farm

The present disclosure is directed to a system and method for forecasting a farm-level power output of a wind farm having a plurality of wind turbines. The method includes collecting actual operational data and/or site information for the wind farm. The method also includes predicting operational data for the wind farm for a future time period. Further, the method includes generating a model-based power output forecast based on the actual operational data, the predicted operational data, and/or the site information. In addition, the method includes measuring real-time operational data from the wind farm and adjusting the power output forecast based on the measured real-time operational data. Thus, the method also includes forecasting the farm-level power output of the wind farm based on the adjusted power output forecast.

ANTI-CHEATING SOLUTION TO DETECT GRAPHICS DRIVER TAMPERING FOR ONLINE GAMING

Embodiments described herein provide an apparatus comprising a processor to receive, from a gaming/anti-cheating server, a message comprising a first pixel data set comprising first pixel data for one or more pixels of a watermark generated by the gaming/anti-cheating server, store the first pixel data set in the machine-readable memory, receive, from a gaming system, a frame buffer rendered by the gaming system and comprising the watermark generated by the gaming/anti-cheating server, isolate, from the frame buffer, a second pixel data set comprising second pixel data for one or more pixels corresponding to the first pixel set, and forward an alert to the gaming/anti-cheating server when the second pixel data differs from the first pixel data by an amount that exceeds a threshold. Other embodiments may be described and claimed. 1. An apparatus , comprising: receive, from a gaming server, a message comprising a first pixel data set comprising first pixel data for one or more pixels of a watermark generated by the gaming server;', 'store the first pixel data set in a machine-readable memory;', 'receive, from a gaming system, a frame buffer rendered by the gaming system and comprising the watermark generated by the gaming server;', 'isolate, from the frame buffer, a second pixel data set comprising second pixel data for one or more pixels corresponding to the first pixel set; and', 'forward an alert to the gaming server when the second pixel data differs from the first pixel data by an amount that exceeds a threshold., 'a processor to2. The apparatus of claim 1 , the processor to:establish a secure communication channel with the gaming server.3. The apparatus of claim 2 , the processor to:exchange a shared secret with the gaming server during an attestation process, wherein the shared secret uniquely identifies a player and a platform; anduse the shared secret to decrypt the first pixel data set.4. The apparatus of claim 1 , the processor to:transmit, in response to ...

Line cut patterning using sacrificial material

A method for fabricating a semiconductor device includes forming a first line pattern within sacrificial mandrel material disposed on at least one hard mask layer disposed on a substrate. The first line pattern has a pitch defined by a target line width and a minimum width of space between lines. The method further includes forming, within the first line pattern, a first spacer having a width corresponding to the minimum width of space between lines to minimize pinch points and a first gap having the target line width, and forming a first plug within the first gap corresponding to a first location above the at least one hard mask layer to block pattern transfer into the at least one hard mask layer.

Magnetically augmented plasmonic tweezers

The present subject matter described herein relates to a Magnetically Augmented Plasmonic Tweezer (MAPT), a method for fabrication of the MAPT, and a method for trapping and maneuvering one or more colloidal particles inside a fluid. The fluid may correspond to a fluid inside a microfluidic device or a biological fluid. The MAPT can comprise a helical support structure to provide maneuverability in fluid. Further, a magnetic component is integrated in the MAPT for motion control. Plasmonic nanostmctures are integrated in the MAPT for optical trapping of particles.

Amantadine compositions, preparations thereof, and methods of use

Provided herein are oral pharmaceutical compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient, and which have a low level of organic solvent. Provided are also methods of orally administrating a composition comprising amantadine, or a pharmaceutically acceptable salt thereof, to a subject, which has reduced gastrointestinal side effects or sleep disturbances. Further provided are extended release oral compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, that are suitable for once daily administration.

PERFORMING USER SEAMLESS AUTHENTICATIONS

In one embodiment, a first device includes: a first logic to generate a first token when a user adapts the first device in approximate contact to the user, the first token including a first timestamp; a storage to store the first token and a second token, the second token obtained from an authenticator and associated with an authentication of the user to a second device, the second token including a second timestamp; and a communication module to communicate the first and second tokens to the second device to cause the second device to authenticate the user based at least in part on the first and second tokens. Other embodiments are described and claimed. 1. A first device comprising:a first logic to generate a first token when a user adapts the first device in approximate contact to the user, the first token including a first timestamp;a storage to store the first token and a second token, the second token obtained from an authenticator and associated with an authentication of the user to a second device, the second token including a second timestamp; anda communication module to communicate the first token and the second token to the second device to cause the second device to authenticate the user based on the first and second tokens.2. The first device of claim 1 , further comprising a controller to remove at least the first token when the first user is no longer in the approximate contact to the first device.3. The first device of claim 2 , further comprising a sensor to detect when the user is in the approximate contact to the first device.4. The first device of claim 1 , wherein the first token includes a plurality of fields including a first field to store the first timestamp and a second field to store a location identifier claim 1 , the location identifier corresponding to a location at which the user adapted the first device in approximate contact to the user.5. The first device of claim 4 , wherein the second token includes a plurality of fields ...

Non-fucosylated protein and methods thereof

The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.

FACIAL SPOOFING DETECTION IN IMAGE BASED BIOMETRICS

Systems and techniques for facial spoofing detection in image based biometrics are described herein. A marker may be created for a representation of a face in a first plurality of images of a sequence of images. The marker corresponds to a facial feature of the face. An environmental feature of an environment of the face may be identified across a second plurality of images of the sequence of images. A correlation between the marker and the environmental feature in the sequence of images may be quantified to produce a synchronicity metric. A spoofing attempt may be indicated in response to the synchronicity metric meeting a threshold. 125.-. (canceled)26. A system for facial spoofing detection in image based biometrics , the method comprising:a biometric feature detector to create a marker for a representation of a face in a first plurality of images of a sequence of images, the marker corresponding to a facial feature;an environmental feature detector to identify an environmental feature of an environment of the face across a second plurality of images of the sequence of images;a synchronicity detector to quantify a correlation between the marker and the environmental feature in the sequence of images to produce a synchronicity metric; anda spoofing indication controller to indicate a spoofing attempt in response to the synchronicity metric meeting a threshold.27. The system of claim 26 , wherein the marker is a line between eyes in the representation of the face.28. The system of claim 26 , wherein the environmental feature includes edges detected in the second plurality of images.29. The system of claim 28 , wherein the edges are moving edges.30. The system of claim 29 , wherein the edges define a convex hull claim 29 , and wherein the convex hull does not include the marker resulting in the synchronicity metric being reduced.31. The system of claim 29 , wherein the first plurality of images does not include a member of the second plurality of images claim 29 , ...

IMAGE QUALITY COMPENSATION SYSTEM AND METHOD

A user authentication system and method. The user authentication system includes a camera and a processor connected to the camera. The processor receives images from the camera, searches for a user feature in the images, determines if the images require correction, adjusts camera controls in a pre-defined order to provide desired corrections, applies the desired corrections to subsequent images and authenticates the user based on the user feature in the corrected images. 125-. (canceled)26. A user authentication system , comprising:a camera; anda processor, connected to the camera, wherein the processor receives images from the camera, searches for a user feature in the images, determines if the images require correction, adjusts camera controls in a pre-defined order to provide desired corrections, applies the desired corrections to subsequent images and authenticates the user based on the user feature in the corrected images.27. The system of claim 26 , wherein the processor adjusts camera controls selected from the group of camera controls consisting of camera controls for exposure claim 26 , for gamma and for gain.28. The system of claim 26 , wherein the processor determines when subsequent images no longer need correction and sets the camera controls to a different configuration.29. The system of claim 26 , wherein the processor determines when subsequent images no longer need correction and sets the camera controls to an initial state.30. The system of claim 26 , wherein the camera includes one or more of a visual light sensor and an infrared sensor.31. A method claim 26 , comprising:capturing images of a user, wherein each image includes a user feature;searching for the user feature in the captured image;determining if the image requires correction;if the image requires correction, adjusting camera controls in a pre-defined order to provide desired corrections; andapplying the corrections to subsequent images.32. The method of claim 31 , wherein adjusting ...

FACIAL LIVENESS DETECTION IN IMAGE BIOMETRICS

System and techniques for spoofing detection in image biometrics are described herein. A sequence of images may be obtained from a camera; a first plurality of images in the sequence of images including a representation of a user body part, and a second plurality of images in the sequence of images including a representation of an environment of the user. A marker may be created for the representation of the body part. A feature of the environment of the user present during the second plurality of images may be identified in the sequence of images using a third group of circuits. A correlation between the marker and the feature of the environment in the sequence of images may be quantified to produce a synchronicity metric of the degree to which the marker and the feature of the environment correlate. 125.-. (canceled)26. A system for facial liveness detection in image biometrics , the system comprising:a biometric feature detector to detecting a set of potential authentication faces in an image sequence captured during an authentication attempt by a user; for each face in the set of potential authentication faces:', 'invoke a synchronicity detector to apply a set of liveness model tests to the face, each test in the set of liveness tests including an assay that differs between a live face and a face simulated on a pictorial representation of a face, the assay operating independently of body arrangement instructions given to the user; and', 'adding the face to a set of authentication faces when the result of the set of liveness model tests meets a threshold; and, 'a liveness indication controller toan authentication controller to apply facial authentication to faces in the set of authentication faces.27. The system of claim 26 , wherein a test in the liveness model of tests includes:an emitter of the system to emit light towards the face;a sensor of the system to measure an interaction of the light with the face; andthe synchronicity detector to compare the ...

SYSTEM AND PROCESS FOR PATTERN MATCHING BEARING VIBRATION DIAGNOSTICS

A system and method including receiving vibration spectrum data from a plurality of different assets; determining, based on a shape of the vibration spectrum data for each of the plurality of assets, clusters for the plurality of assets, assets being grouped in a same cluster having vibration spectrum data of a similar spectral shape; determining for each of the clusters, based on an application of domain derived pattern recognition rules for the vibration spectrum data, one of a plurality of fault classifications; generating an output including an association of each of the plurality of assets with the fault classification of the cluster in which the particular asset is grouped; and saving a record of the output.

SPOOFING DETECTION IN IMAGE BIOMETRICS

System and techniques for spoofing detection in image biometrics are described herein. A sequence of images may be obtained from a camera; a first plurality of images in the sequence of images including a representation of a user body part, and a second plurality of images in the sequence of images including a representation of an environment of the user. A marker may be created for the representation of the body part. A feature of the environment of the user present during the second plurality of images may be identified in the sequence of images using a third group of circuits. A correlation between the marker and the feature of the environment in the sequence of images may be quantified to produce a synchronicity metric of the degree to which the marker and the feature of the environment correlate. 1. (canceled)2. A system for spoofing detection in image biometrics , the method comprising:a camera to obtain a sequences of images, a first plurality of images in the sequence of images including a representation of a user body part, and a second plurality of images in the sequence of images including a representation of an environment of the user, the environment being a three-dimensional space that is within a field of view of the camera;a biometric feature detector to create a marker for the representation of the body part, the marker corresponding to a feature in the representation of the body part;an environmental feature detector to identify a feature of the environment of the user present during the second plurality of images in the sequence of images;a synchronicity detector to quantify a correlation between the marker and the feature of the environment in the sequence of images to produce a synchronicity metric of the degree to which the marker and the feature of the environment correlate; anda spoofing indication controller to provide a spoofing attempt indication in response to the synchronicity metric being beyond a threshold.3. The system of wherein to ...

Excess loop delay estimation and correction

An analog-to-digital convertor circuit converts the output of a loop filter circuit to a digital signal. A random sequence generation circuit generates a random sequence. Adder circuitry adds the random sequence to the digital signal to generate a randomized digital signal. Noise transfer function impulse response detection circuitry processes the randomized digital signal and the random sequence to determine a noise transfer function impulse response. Loop filter configuration circuitry configures the loop filter circuit based on the noise transfer function impulse response. The random sequence generation circuit may comprises a high-pass sigma delta modulator. The noise transfer function impulse response detection circuitry may determine the noise transfer function impulse response, and the loop filter configuration circuitry may configure the loop filter based on the noise transfer function impulse response. The loop filter configuration circuitry may generate loop filter coefficients based on the noise transfer function impulse response.

Protease-containing cleaning compositions

The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).

Spin on scaffold film for forming topvia

A method of manufacturing a semiconductor device is provided. The method includes forming a plurality of metal lines on substrate, forming a sacrificial dielectric material layer between the metal lines, forming a hardmask over at least one of the metal lines, etching at least one of the metal lines that is not covered by the hardmask, treating the sacrificial dielectric material layer to soften the layer. The method also includes removing the treated sacrificial dielectric material layer.

Upgradation of undesirable olefinic liquid hydrocarbon streams

A process for converting undesirable olefinic hydrocarbon streams to hydrogen and petrochemical feedstock e.g. light olefins in C 2 -C 4 range and aromatics especially toluene and xylenes, which comprises simultaneous cracking and reforming at olefin rich hydrocarbons using a catalyst consisting of dehydrogenating metal components, shape selective zeolite components and large pore acidic components in different proportions in a circulating fluidized bed reactor-regenerator system having reactor temperature within 450-750° C. and WHSV of 0.1-60 hour -1 .

Process for the preparation of supported aluminium chloride catalyst containing organo aluminium compound

A process for the preparation of an inert oxide supported metal halide organo aluminium compound catalyst. The catalyst is obtained by reacting an activated support having surface hydroxyl groups with aluminium chloride selected from aluminium chloride solution and aluminium chloride vapors. A solution of an aluminium alkyl is added to the reacted support. The solvent is removed and the reacted support is dried.

Catalyst for oligomerization of alpha-olefins

A catalyst composition for use in oligomerization of olefins contained in refinery distillate streams including paraffins, naphthenes, and aromatics therein, the catalyst consisting of a first constituent which is at least one aluminum halide; and a second constituent which is at least one alkoxide of a transition metal of Group IVB of the Periodic Table and which has a general formula: M(OR).sub.4, where M is selected from the group consisting of metals of Group IVB of the Periodic Table and R is one of (a) an alkyl group having from 1-12 carbon atoms or (b) an alkylaryl group having an alkyl chain having from 1-12 carbon atoms.

Oligomerization of alpha-olefins

This invention relates to a catalyst composition capable of effecting selective oligomerisation of olefins contained in cracked refinery distillate streams, comprising of olefins, aromatics, paraffins and cycloparaffins. The catalyst composition gives very high conversion of olefins to poly olefins, which after distillation and stabilization by hydrogenation affords lubricating oil base stocks. The catalyst composition comprises of an aluminum halide and a transition metal alkoxide belonging to group IVB.

Protease-containing cleaning compositions

A találmány tárgyát tisztítókészítmények képezik, melyek tartalmaznak:a) hatásos mennyiségű proteázenzimet, amely egy természetben elő nemforduló aminosavszekvenciával rendelkező karbonil-hidroláz-változat,amely egy szubtilizin prekurzor karbonil-hidrolázból származikhelyettesítve a prekurzor karbonil-hidrolázban a +76. helyzetűaminosavmaradékot és egy vagy több aminosavma- radékot a +27., +99.,+101., +103., +104., +105, +107., +109., +123., +126., +128., +135.,+156., +166., +195., +197., +204., +206., +210., +216., +217., +218.,+222., +260., +265. és/vagy +274. helyzetben, melyek ekvivalenshelyzetűek a Bacillus amyloliquefaciens szubtilizinaminosavmaradékaival; és b) egy vagy több, a proteázenzimmelösszeegyeztethető tisztítókészítmény-anyagot. A találmány szerintitisztítókészítmények felölelik a karbonil-hidroláz-enzimet tartalmazómosószereket, mosogatószereket, személyi tisztálkodásra szolgálókészítményeket. A találmány továbbá tisztítóeljárásokra is vonatkozika fenti készítményekkel. ŕ

Activity recommendation based on a real-time mapping between activity characteristics and autonomous vehicle dynamics

An approach for recommending an activity during travel. The approach includes receiving a request for a travel destination and a desired arrival time. Furthermore, the approach determines a route to the travel destination and retrieves external data based on the route. Based on the retrieved data and the route, the approach calculates and outputs an initial activity list. And the approach measures vehicle dynamics based on one or more motion sensors and updates and outputs the activity list based on the vehicle dynamics.

Biologically active dry powder compositions and method of their manufacture and use

Dry powder compositions comprising biologically active polynucleotide molecules and methods for the manufacture of such dry powders are provided. In some aspects, dry powders of the embodiment comprise expressible or regulatory (e.g., siRNA) polynucleotide molecules complexed with nanoparticles. Dry powders comprising viable virus and bacteria are also provided.

Impregnated electrode for capacitive deionisation, process for preparing it and apparatus employing the electrodes

Disclosed is an electrode an electrode for capacitive deionization comprising (i) an adsorbent having specific surface area of 100 m 2/g to 1300 m 2/g; (ii) conductive carbon black; and (iii) a binder; wherein said adsorbent is impregnated with a substance having conductivity in the range of 105 S/m to 107 S/m and standard hydrogen potential in the range of -0.3 V to +1.3 V. The electrode provides enhanced recovery and greater reduction in total solids and is more energy efficient. The process or preparing the electrode and a gravity fed water purification apparatus incorporating said electrode re also disclosed.

Bleaching compositions comprising protease enzymes

The invention herein provides bleaching compositions comprising a protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin) and a bleaching agent.

Multiply-substituted protease variant and amylase variant-containing cleaning compositions

The present invention relates to cleaning compositions comprising a protease variant and an amylase variant. One cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution at one or more other positions. Another cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue position corresponding to positions 62, 212, 230, 232 and 257 of Bacillus amyloliquefaciens subtilisin. Method for using the cleaning composition is also provided.

BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted

The present invention relates to subtilisin BPN′ variants having a modified amino acid sequence of wild-type BPN′ amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region and a fifth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin BPN′ (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the BPN′ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin BPN′. The present invention also relates to the genes encoding such subtilisin BPN′ variants. The present invention also relates to compositions comprising such subtilisin BPN′ variants for cleaning a variety of surfaces.

Process for removing trace amounts of ammonia-containing compounds from aqueous streams

A method for removing trace amounts of ammonia and ammonia-containing compounds from process water involving the destruction of the ammonia by oxidative procedures which includes the steps of: concentrating ammonia and ammonium ions removed from the process water stream into contact with a suitable catalytic-adsorbent material contained in a plurality of discrete reaction vessels; and contacting at least one of the reaction vessels and the catalytic-adsorbent contained therein with an alkaline oxidative solution capable of converting the concentrated ammonia and ammonium ions to simple environmentally neutral compounds.

DNA binding domain of the CRISPR system for the production of non-fucosylated and partially fucosylated proteins

Un dominio de unión a ADN del sistema CRISPR, en donde el dominio de unión a ADN comprende una secuencia de ARN transcrita a partir de la secuencia de nucleótidos seleccionada del grupo que consiste en la SEQ ID NO: 41, la SEQ ID NO: 43 y la SEQ ID NO: 45. A DNA-binding domain of the CRISPR system, wherein the DNA-binding domain comprises an RNA sequence transcribed from the nucleotide sequence selected from the group consisting of SEQ ID NO: 41, SEQ ID NO: 43 and SEQ ID NO: 45.

WHITENING COMPOSITIONS INCLUDING PROTEASA ENZYMES.

LA PRESENTE INVENCION PROPORCIONA COMPOSICIONES BLANQUEADORAS QUE CONTIENEN UNA ENZIMA PROTEASA QUE ES UNA VARIANTE DE LA CARBONIL HIDROLASA CON UNA SECUENCIA AMINOACIDA QUE NO SE ENCUENTRA EN LA NATURALEZA, QUE SE DERIVA REEMPLAZANDO UNA PLURALIDAD DE RESIDUOS AMINOACIDOS DEL PRECURSOR DE LA CARBONIL HIDROLASA CON DISTINTOS AMINOACIDOS, EN LA QUE DICHA PLURALIDAD DE RESIDUOS AMINOACIDOS REEMPLAZADOS EN LA ENZIMA PRECURSORA CORRESPONDEN A LAS POSICIONES +76 EN COMBINACION CON UNO O MAS DE LOS SIGUIENTES RESIDUOS: +99, +101,+103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, Y/O +274, EN LA QUE LAS POSICIONES NUMERADAS CORRESPONDEN A SUBTILISINA PRODUCIDA NATURALMENTE A PARTIR DEL BACILO AMILOLIQUEFACIENS O A RESIDUOS AMINOACIDOS EQUIVALENTES EN OTRAS CARBONIL HIDROLASAS O SUBTILISINAS (COMO LA SUBTILISINA DEL BACILO LENTUS) Y A UN AGENTE BLANQUEADOR. THE PRESENT INVENTION PROVIDES WHITENING COMPOSITIONS CONTAINING A PROTEASE ENZYME WHICH IS A VARIANT OF CARBONIL HYDROLASSES WITH AN AMINOTIATED SEQUENCE THAT IS NOT FOUND IN NATURE, WHICH IS DERIVED REPLACING A PLURALITY OF AMINO ACIDOSDOSDOSOS, AMINO IN WHICH SUCH PLURALITY OF AMINO ACID WASTE REPLACED IN THE PRECURSOR ENZYME CORRESPOND TO THE POSITIONS +76 IN COMBINATION WITH ONE OR MORE OF THE FOLLOWING WASTE: +99, + 101, + 103, +104, +107, +123, +27 , +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, + 260, +265, AND / OR +274, IN WHICH THE NUMBERED POSITIONS CORRESPOND TO NATURALLY PRODUCED SUBTILISINE FROM AMILOLIQUEFACIENS BACIL OR TO EQUIVALENT AMINO ACID RESIDUES IN OTHER CARBONIL HYDROLASES OR SUBTILISINING BINDERS.

Recombinant heme oxygenase-1 (ho-1) for the treatment of sickle cell disease

The present invention provides, among other things, methods and compositions for making and using recombinant heme oxygenase for treating sickle cell disease. In some embodiments, recombinant heme oxygenase proteins are truncation variants, or Fc fusion proteins with increased half-life and/or reduced aggregation.

Electric toothbrush comprising an electrically powered element

An electric toothbrush having a handle, a head, and a neck extending between the handle and the head is disclosed. The handle has a hollow interior region having a motor and an electrical power source. The head includes an ultrasonic transducer and a bristle field. The ultrasonic transducer is in electrical communication with the electrical power source, and a shaft is operatively connected to the motor for moving the bristle field.

GIP and exendin hybrid polypeptides

The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.

Cleaning compositions containing protease

Protease-containing cleaning compositions

The present invention relates to cleaning compositions comprising protease e nzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbon yl hydrolase with different amino acids, wherein said plurality of amino acid r esidues replaced in the precursor enzyme correspond to p osition +76 in combination with one or more of the following residues: +99, +101, +1 03, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265 , and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equival ent amino acid residues in other carbonyl hydrolase or s ubtilisins (such as Bacillus lentus subtilisin).

Protease-containing cleaning compositions

The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).

Protease-containing cleaning compositions

The present invention relates to cleaning compositions comprising subtilisin proteases from Bacillus lentus having the following alterations: N76D, S103A and V104I, where the numbering is based on the corresponding positions in the subtilisin from Bacillus amyloliquefaciens.

Protease-containing cleaning compositions

The present invention relates to cleaning compositions comprising subtilisin proteases from Bacillus lentus having the following alterations: N76D, S103A and V104I, where the numbering is based on the corresponding positions in the subtilisin from Bacillus amyloliquefaciens.

Cleaning agent, agent for cleaning fabrics, agent for washing dishes, washing agent, method of cleaning fabrics, method of washing dishes and washing process

The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from <u>Bacillus amyloliquefaciens</u> or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as <u>Bacillus lentus</u> subtilisin).

CLEANING COMPOSITIONS CONTAINING PROTEASE.

LA PRESENTE INVENCION SE REFIERE A COMPOSICIONES LIMPIADORAS QUE CONTIENEN LA ENZIMA PROTEASA QUE ES UNA VARIANTE DE LA CARBONIL HIDROLASA Y A UNA SECUENCIA AMINOACIDA QUE NO SE ENCUENTRA EN LA NATURALEZA, QUE SE DERIVA REEMPLAZANDO UNA PLURALIDAD DE RESIDUOS AMINOACIDOS DEL PRECURSOR DE LA CARBONIL HIDROLASA CON DISTINTOS AMINOACIDOS, EN LAS QUE DICHA PLURALIDAD DE RESIDUOS AMINOACIDOS REEMPLAZADOS EN LA ENZIMA PRECURSORA CORRESPONDEN A LAS POSICIONES +76 EN COMBINACION CON UNO O MAS DE LOS SIGUIENTES RESIDUOS: +99, +101,+103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, Y/O +274, EN LAS QUE LAS POSICIONES NUMERADAS CORRESPONDEN A SUBTILISINA PRODUCIDA NATURALMENTE A PARTIR DEL BACILO AMILOLIQUEFACIENS O A RESIDUOS AMINOACIDOS EQUIVALENTES EN OTRAS CARBONIL HIDROLASAS O SUBTILISINAS (COMO LA SUBTILISINA DEL BACILO LENTUS). THE PRESENT INVENTION REFERS TO CLEANING COMPOSITIONS CONTAINING THE PROTEASE ENZYME WHICH IS A VARIANTE OF CARBONIL HYDROLASA AND AN AMINOACIA SEQUENCE THAT IS NOT FOUND IN NATURE, WHICH IS DERIVED REPLACING A PLURALITY OF RESIDUES DRAWNED HARDWOOD AMINO ACIDS, IN WHICH SUCH PLURALITY OF AMINO ACID WASTE REPLACED IN THE PRECURSOR ENZYME CORRESPOND TO THE POSITIONS +76 IN COMBINATION WITH ONE OR MORE OF THE FOLLOWING RESIDUES: +99, + 101, + 103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222 , +260, +265, AND / OR +274, IN WHICH THE NUMBERED POSITIONS CORRESPOND TO NATURALLY PRODUCED SUBTILISINE FROM AMILOLIQUEFACIENS BACIL OR TO EQUIVALENT AMINO ACIDS IN OTHER CARBONIL HYDROLASES OR SUBTILISINES.

Bleaching compositions comprising multiply-substituted protease variants

The present invention relates to bleaching compositions comprising a protease variant. One bleaching composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 1, 3, 4, 8, 9, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274, and 275 of Bacillus amyloliquefaciens subtilisin; wherein when said protease variant includes a substitution of amino acid residues at positions corresponding to positions 103 and 76, there is also a substitution of an amino acid residue at one or more amino acid residue positions other than amino acid residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265, or 274 of Bacillus amyloliquefaciens subtilisin, a bleaching agent; and one or more cleaning adjunct materials. Another bleaching composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 62, 212, 230, 232, 252 and 257 of Bacillus ...

Protease-containing cleaning compositions

The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).

Bleaching compositions comprising protease enzymes

The invention herein provides bleaching compositions comprising a protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin) and a bleaching agent.

Bleaching compositions comprising multiply-substituted protease variants

The present invention relates to bleaching compositions comprising a protease variant. One bleaching composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 1, 3, 4, 8, 9, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274, and 275 of Bacillus amyloliquefaciens subtilisin; wherein when said protease variant includes a substitution of amino acid residues at positions corresponding to positions 103 and 76, there is also a substitution of an amino acid residue at one or more amino acid residue positions other than amino acid residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265, or 274 of Bacillus amyloliquefaciens subtilisin, a bleaching agent; and one or more cleaning adjunct materials. Another bleaching composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 62, 212, 230, 232, 252 and 257 of Bacillus ...

BPN′ variants having decreased adsorption and increased hydrolysis

The present invention relates to subtilisin BPN′ variants comprising at least one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPN′ (i.e., substitution) at specifically identified positions, whereby the BPN′ variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPN′. The present invention further relates to various cleaning compositions comprising such BPN′ variants.

Cleaning compositions containing multiply-substituted protease variants

The present invention relates to cleaning compositions comprising a protease variant. One cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 1, 3, 4, 8, 9, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274 and 275 of Bacillus amyloliquefaciens subtilisin; wherein when said protease variant includes a substitution of amino acid residues positions corresponding to positions 103 and 76, there is also a substitution of an amino acid residue at one or more amino acid residue positions other than amino acid residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin; and one or more cleaning adjunct materials. Another cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue positions corresponding to positions 62, 212, 230, 232, 252 and 257 of $( Bacillus amyloliquefaciens ) subtilisin; ...

Granular detergents with protease enzyme and bleach

A találmány szerinti mosószerek A) 0,5–20 tömeg% fehérítőszert, amelyvízben oldhatatlan szerves peroxisav vagy fehérítőaktivátor és azaktivátorral a fehérítőoldatban in situ szerves peroxisav képzésérehidrogén-peroxidot termelő peroxigénvegyület kombinációjából áll, és aperoxisavnak megfelelő karbonsavnak 3 és 6,5, előnyösen 4,0 és 6,5közötti hidrofil-- lipofil egyensúlyi értéke van; B) 0,064 és 0,64 mg,előnyösen 0,096 és 0,32 mg közötti mennyiségű aktív proteázenzimet 1 gkészítményre vonatkoztatva; C) 1–40 tömeg% anionos, nemionos, amfolitvagy ikerionos felületaktív anyagot vagy keveréküket, előnyösen 2– 20tömeg% anionos felületaktív anyagot tartalmaznak, továbbá aproteázenzim elegendő mennyiségben van jelen ahhoz, hogy a mg/100 gkészítményben kifejezett aktív proteáz mennyiségének és amosófolyadékban a peroxisavból képződő, elméletileg rendelkezésre állóoxigén ppm-ben kifejezett mennyiségének aránya (1:1) és (20:1) közöttlegyen. ŕ

Multiply-substituted protease variant and amylase variant-containing cleaning compositions

The present invention relates to cleaning compositions comprising a protease variant and an amylase variant. One cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at an amino acid residue position corresponding to position 103 of Bacillus amyloliquefaciens subtilisin in combination with a substitution at one or more other positions. Another cleaning composition comprises a protease variant including a substitution of an amino acid residue with another naturally occurring amino acid residue at one or more amino acid residue position corresponding to positions 62, 212, 230, 232 and 257 of Bacillus amyloliquefaciens subtilisin. Method for using the cleaning composition is also provided.

Protease-containing cleaning compositions

Protease-containing cleaning compositions

Protease-containing cleaning compositions

The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolase or subtilisins (such as Bacillus lentus subtilisin).

PROTEASE-CONTAINING CLEANING AGENTS

Cleaning composition containing protease

(57)【要約】 （修正有） 【課題】改善されたタンパク質分解活性を有したカルボ ニルヒドロラーゼ変種であるプロテアーゼ酵素を含有す るクリーニング組成物を提供する。 【解決手段】異なるアミノ酸による前駆カルボニルヒド ロラーゼの複数アミノ酸残基で置換されたプロテアーゼ 酵素（前駆酵素置換の複数アミノ酸残基は＋７６位と、 以下の残基：＋９９、＋１０１、＋１０３、＋１０４、 ＋１０７、＋１２３、＋２７、＋１０５、＋１０９、＋ １２６、＋１２８、＋１３５、＋１５６、＋１６６、＋ １９５、＋１９７、＋２０４、＋２０６、＋２１０、＋ ２１６、＋２１７、＋２１８、＋２２２、＋２６０、＋ ２６５および／または＋２７４のうち１以上とに相当す る）を含むクリーニング組成物。

Subtilisin 309 variants having decreased adsorption and increased hydrolysis

The present invention relates to subtilisin (309) variants having a modified amino acid sequence of wild-type subtilisin (309) amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin (309) (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the subtilisin (309) variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild type subtilisin (309). The present invention also relates to DNA sequence encoding such subtilisin (309) variants. The present invention also relates to compositions comprising such subtilisin (309) variants for cleaning a variety of surfaces.

Healthy building dashboard facilitated by hierarchical model of building control assets

A spatial hierarchical model provides spatial context to a plurality of building control assets disposed within a plurality of hierarchical levels of the spatial hierarchical model. A method includes identifying non-compliance events detected by building control assets disposed at and below a particular hierarchical level of the spatial hierarchical model. The non-compliance events detected by building control assets disposed at and below the particular hierarchical level of the spatial hierarchical model over a period of time are aggregated and a healthy building dashboard that includes a representation of the aggregated non-compliance events for each of at least some of the one or more of the healthy building criteria detected by building control assets disposed at and below the particular hierarchical level of the spatial hierarchical model is generated and is displayed on a display.

Method and apparatus for providing personalized relevant information

A method and apparatus for providing to a user personalized information from an database comprising contributor content records and contributor profile records, based upon a comparison of the user's search query and user profile record with the contributor content records and contributor profile records. The database may contain other content records from which personalized information may be obtained. Contributors may provide additional contributor content records to the database, in exchange for valuable consideration.

A process for the production of a fly ash slurry

The present invention describes an improved method for forming fly ash slurry by mixing fly ash and water with an additive containing 0.5 -2 wt % ammonium salt of humic acid and 0.03 to 0.05 wt % tannin extract. The product slurry does not require large amount of water for transport to storage space due to its enhanced viscosity and stability.

Touch-related contamination state determinations

In an example, a non-transitory machine-readable storage medium may include instructions that, when executed by a processor of a computing device, cause the processor to receive device usage data associated with an electronic device. Further, instructions may be executed by the processor to determine a touch-related contamination state of a surface of the electronic device by applying a machine learning model to the device usage data. Furthermore, instructions may be executed by the processor to send an alert notification to the electronic device based on the touch-related contamination state.

Methods and compositions for the treatment of seizure-related disorders

Compositions and methods are provided for administering a pharmaceutical composition to a human patient. Compositions are administered to a human patient orally, once daily, at a therapeutically effective dose. The pharmaceutical compositions comprise a drug selected from the group consisting of brivaracetam, divalproex, lacosamide, levetiracetam, oxcarbazepine, vigabatrin, and pharmaceutically acceptable salts of any of the foregoing, and at least one excipient. At least one of said at least one excipients modifies the release of said drug to provide an extended release form. The pharmaceutical composition have pharmacokinetic properties recited in the claims.

Biologically active dry powder compositions and method of their manufacture and use

Dry powder compositions comprising biologically active polynucleotide molecules and methods for the manufacture of such dry powders are provided. In some aspects, dry powders of the embodiment comprise expressible or regulatory (e.g., siRNA) polynucleotide molecules complexed with nanoparticles. Dry powders comprising viable virus and bacteria are also provided.

Small molecule sting antagonists

The present invention relates to compounds of formula (I). The compounds maybe used to antagonise the Stimulator of Interferon Genes (STING) protein and may thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis (NASH), pulmonary fibrosis, lupus, sepsis, rheumatoid arthritis (RA), type I diabetes, STING- associated vasculopathy with onset in infancy (SAVI), Aicardi-Goutieres syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), retinal vasculopathy, neuroinflammation, systemic inflammatory response syndrome, pancreatitis, cardiovascular disease, renal fibrosis, stroke and age-related macular degeneration (AMD).

Coatings for modifying hard surfaces and processes for applying the same

Materials for coating, coating compositions, methods and articles of manufacture comprising a nanoparticle system or employing the same to impart surface modifying benefits for all types of hard surfaces are disclosed. In some embodiments, dispersement of nanoparticles in a suitable carrier medium allows for the creation of coating compositions, methods and articles of manufacture that create multi-use benefits to modified hard surfaces. In some embodiments, actively curing the coating composition on the hard surfaces, including, but not limited to by radiative heating the air surrounding the hard surface with the coating thereon can be used to increase the durability of the hard surface coating.

Methods for screening protease variants for use in detergent compositions

Methods for screening protease variants for use in detergent systems are provided. Such methods relate to the net charge of the substitutions of the protease variants and the adsorption properties of the protease variants. Also included are detergent compositions comprising protease variants screened by such methods.

Ceramic article

(57)【要約】 【課題】 表面導電性を有するセラミック物品を提供す ること。 【解決手段】 正方晶系ジルコニア合金又はその複合体 を含むコア／バルク部とホウ化ジルコニウムを含むシェ ル／表面部とを含んで成るセラミック物品。

Beta-secretase inhibitors and methods of use

3-cyanoquinoline tablet formulations and uses thereof

The present invention provides solid compositions comprising a 3-cyanoquinoline, SKI-606, and further comprising croscarmellose sodium, Tween, or both.

A process for the production of a fly ash slurry

The present invention describes an improved method for forming fly ash slurry by mixing fly ash and water with an additive containing 0.5 -2 wt % ammonium salt of humic acid and 0.03 to 0.05 wt % tannin extract. The product slurry does not require large amount of water for transport to storage space due to its enhanced viscosity and stability.

HIV PROTEASE INHIBITORS USED TO TREAT AIDS

INHIBITORS OF MEMAPSIN 2 AND ITS USE

Coating compositions for modifying hard surfaces

Materials for coating, coating compositions, methods and articles of manufacture comprising a nanoparticle system or employing the same to impart surface modifying benefits for all types of inanimate hard surfaces are disclosed. In some embodiments, dispersement of nanoparticles in a suitable carrier medium allows for the creation of coating compositions, methods and articles of manufacture that create multi-use benefits to modified hard surfaces. These surface modifications can produce long lasting or semi-permanent multi-use benefits that include at least one of the following improved surface properties: wetting and sheeting, quick drying, uniform drying, soil removal, self-cleaning, anti-spotting, anti-soil deposition, cleaner appearance, enhanced gloss, enhanced color, minor surface defect repair, smoothness, anti-hazing, modification of surface friction, release of actives and transparency, relative to hard surfaces unmodified with such nanoparticle systems. In some embodiments, actively curing the coating composition on the hard surfaces, including, but not limited to by radiative heating the air surrounding the hard surface with the coating thereon can be used to increase the durability of the hard surface coating.

Systems and methods for optimized region growing algorithm for scale space analysis

The present invention provides a system, method and computer program product for improving quality of images. The pixels of the input image are used to generate two lists of pixels based on two different scale space values. Thereafter, the two pixels lists are processed to obtain an output image with improved quality.

Patent IN160579B

Afucosylated protein, cell expressing said protein and associated methods

The present disclosure relates to methods of obtaining cell with disrupted fucosylation and obtaining afucosylated protein. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology in a protein producing cell line to produce afucosylated protein. The resulting protein, specifically the resulting monoclonal antibody is completely afucosylated and reveals higher degree of antibody dependent cellular cytotoxicity.

Method and compositions for treating hiv infections

Described herein are compounds and compositions that are useful in the treatment of HIV, AIDS, and AIDS-related diseases. In addition, compounds are described herein that are capable of inhibiting the dimerization of HIV proteases.

Cleansing agents containing multiply substituted protease variants

Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue corresponds to position 103 in combination with one or more of the following substitutions at residue positions corresponding to positions 1, 3, 4, 8, 10, 12, 13, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87, 89, 97, 98, 99, 101, 102, 104, 106, 107, 109, 111, 114, 116, 117, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160, 166, 167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 222, 224, 227, 228, 230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265, 268, 269, 270, 271, 272, 274 and 275 of Bacillus amyloliquefaciens subtilisin, wherein when a substitution at a position corresponding to residue position 103 is combined with a substitution at a position corresponding to residue position 76, there is also a substitution at one or more residue positions other than residue positions corresponding to positions 27, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216, 217, 218, 222, 260, 265 or 274 of Bacillus amyloliquefaciens subtilisin.

Rotor support system having a shape memory alloy

A rotor support system for a gas turbine engine is disclosed. The rotor support system includes a bearing support flange, a frame support flange proximate to the bearing support flange, a fastener between the bearing support flange and the frame support flange, a damping component, and an axial retainer. The damping component includes a super-elastic shape memory alloy. The fastener is configured to fail when a load on the fastener exceeds a threshold value and the damping component is configured to deform from a normal state to a deformed state after the fastener fails. The axial retainer is configured to retain the bearing support flange and the frame support flange within an axial displacement from each other after the fastener fails. A radial gap exists between the bearing support flange and the frame support flange when the damping component is in the normal state.

Bleaching compounds comprising peroxyacid activators used with enzymes

The present invention relates to laundry detergent composition comprising conventional detergent ingredients, bleaching systems with one or more bleach activators, and one or more types of detersive enzymes. Preferred bleaching activators are amido-derived bleach activators and/or N-acyl caprolactam bleach activators. The invention also relates to methods of using the detergent compositions.

Antimicrobial agents

Method and apparatus of nondestructive testing a sealed product for leaks

A leak detection system for testing a sealed product for leaks includes a test chamber, a pressure system that is operable to maintain a substantially constant pressure during a test period, and a leak sensor coupled to the test chamber via a first conduit and the pressure system via a second conduit. The test chamber of the leak detection system includes a receptacle dimensioned to receive the sealed product. Moreover, the test chamber includes a cover dimensioned to operably seal the receptacle at an initial internal pressure when placed into position with the receptacle. The leak sensor of the leak detection system is operable to permit gas flow between the test chamber and the pressure system via the first conduit and the second conduit. The leak sensor is also operable to obtain a value representative of total mass of the gas flow between the sealed test chamber and the pressure system during the test period. Furthermore, the leak detection system is operable to determine, based upon the value obtained for the total mass of the gas flow, whether the sealed product leaked an unacceptable amount during the test period.

Antimicrobial agents

Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Rickettsiae, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.