13-06-2013 дата публикации
Номер: US20130149392A1
The present invention is a method for treating non-small cell lung cancer in a subject in need thereof, comprising administering to the subject an effective amount of a bis(thiohydrazideamide) compound of formula (I): 2. The method of claim 1 , wherein Z is O claim 1 , Rand Rare the same and Rand Rare the same.6. The method of claim 1 , wherein Ris —H and Ris —H claim 1 , an alkyl or substituted alkyl group.7. The method of claim 1 , wherein Rand Rare each an alkyl group optionally substituted with —OH claim 1 , halogen claim 1 , phenyl claim 1 , benzyl claim 1 , pyridyl claim 1 , or C1-C8 alkoxy and Ris —H or methyl.8. The method of claim 1 , wherein Rand Rare each an optionally substituted phenyl group.9. The method of claim 1 , wherein the phenyl group represented by Rand the phenyl group represented by Rare optionally substituted with one or more groups selected from: —R claim 1 , —OH claim 1 , —Br claim 1 , —Cl claim 1 , —I claim 1 , —F claim 1 , —OR claim 1 , —O—COR claim 1 , —COR claim 1 , —CN claim 1 , —NCS claim 1 , —NO claim 1 , —COOH claim 1 , —SOH claim 1 , —NH claim 1 , —NHR claim 1 , —N(RR) claim 1 , —COOR claim 1 , —CHO claim 1 , —CONH claim 1 , —CONHR claim 1 , —CON(RR) claim 1 , —NHCOR claim 1 , —NRCOR claim 1 , —NHCONH claim 1 , —NHCONRH claim 1 , —NHCON(RR) claim 1 , —NRCONH claim 1 , —NRCONRH claim 1 , —NRCON(RR) claim 1 , —C(═NH)—NH claim 1 , —C(═NH)—NHR claim 1 , —C(═NH)—N(RR) claim 1 , —C(═NR)—NH claim 1 , —C(═NR)—NHR claim 1 , —C(═NR)—N(RR) claim 1 , —NH—C(═NH)—NH claim 1 , —NH—C(═NH)—NHR claim 1 , —NH—C(═NH)—N(RR) claim 1 , —NH—C(═NR)—NH claim 1 , —NH—C(═NR)—NHR claim 1 , —NH—C(═NR)—N(RR) claim 1 , —NR—C(═NH)—NH claim 1 , —NR—C(═NH)—NHR claim 1 , —NR—C(═NH)—N(RR) claim 1 , —NR—C(═NR)—NH claim 1 , —NR—C(═NR)—NHR claim 1 , —NR—C(═NR)—N(RR) claim 1 , —NHNH claim 1 , —NHNHR claim 1 , —NHNRR claim 1 , —SONH claim 1 , —SONHR claim 1 , —SONRR claim 1 , —CH═CHR claim 1 , —CH═CRR claim 1 , —CR═CRR claim 1 , —CR═CHR claim 1 , —CR═CRR claim 1 , —CCR ...
Подробнее