CONNECTOR HOUSING ASSEMBLY HAVING A PIN PROTECTOR PLATE

A connector assembly disclosed herein includes a male connector housing, female connector housing and a pin protector plate. The male connector housing includes a resilient finger having an engagement member spaced apart from an upper catch. The female connector housing includes a protruding member axially offset from a retention member. The pin protector plate is disposed between the male connector housing and the female connector housing and includes a tab and a peripheral catch. The tab projects upwardly from the base and is axially offset from the peripheral catch. The pin protector plate is movable from a locked position to a pre-stage position. Wherein the female connector housing is configured to move the pin protector in a pre-stage position when the female connector housing is removed. Accordingly, the male terminal blades remain protected during the servicing of the connector assembly.

Groin protector

A groin protector for use during physical activity, comprising a cup portion 2 and at least one flange 3, wherein said flange is curved and extends from the cup, characterised in that the flange is suitable to rest against the body of the user. The cup portion and flange may be rigidly connected and may comprise a continuous member, and in use the flange may abut the pubic bones of the user. The protector may comprise a supporting foot portion and a cushioning lip 7, which may be a continuous or partial ring around the edge of the groin protector. The cup portion and the flange may both comprise either a substantially rigid or resiliently flexible material. The protector may further comprise protective pads, which may comprise at least one aperture, to protect additional areas of the users body. The groin protector may be reduced in dimension such that the protector fits the female anatomy.

A helmet

SIMPLIFIED RATCHET STRAP AND BUCKLE ASSEMBLY

Disclosed is a ratchet strap and buckle assembly comprising an adjustment ratchet strap comprising a ratchet strap end, and a plurality of ratchet teeth arranged thereon and a single-piece buckle having a locking tooth and a flexible top element, wherein the single-piece buckle comprises a passageway for the ratchet strap end to be inserted therein, and wherein the flexible top element is configured to engage with at least one of the plurality of ratchet teeth using the locking tooth upon insertion.

A helmet

The helmet comprises a protective shell 10 formed of a flexible expanded polyurethane (EPU) material which defines a cavity to receive the wearers head. The shell is foldable and the helmet further comprises a strap arrangement 11 for fastening the shell to the wearers head. The shell may comprise a plurality of different layers of EPU if different densities or compositions. The shell may comprise of a plurality of fingers extending radially from a locus 18. The fingers may be arranged to have a central finger 12 and symmetrical middle 13L/R and side fingers 14L/R either side of it. The strap arrangement may comprise of a head strap 21, side strap and/or chin strap 20. The head strap may comprise of a first and second strap member 22A/B that may pass through an X shaped retainer 23 behind the wearers head.

Simplified ratchet strap and buckle assembly

A ratchet strap and buckle assembly 1 comprising an adjustment ratchet strap 20 having a ratchet strap end 21 and a plurality of teeth 22; and a single piece buckle 14 having a locking tooth and a flexible top element; the single piece buckle comprising a passageway for the ratchet strap, the flexible top element being configured to engage with at least one of the ratchet teeth using the locking tooth upon insertion into the passageway. The buckle preferably comprises stop features 12 to regulate movement of the top element, and support bars inside the passageway to limit vertical movement of the strap. The ratchet teeth may have a sloping front face and vertical rear face, and are arranged perpendicular to the direction of insertion. The material used may be one of polypropylene, nylon, or acetal plastic.

Gas barrier packaging board

A paperboard structure having gas barrier properties which is cost effective and reduces the effect of pinholes. The layer applied to the paperboard is a polyolefin and the product contacting the product is polyolefin. The polyolefin may be low density polyethylene, linear low density polyethylene, metallocene-catalyzed linear low density polyethylene, and a blend of low density polyethylene and either linear low density polyethylene or metallocene-catalyzed linear low density polyethylene. One of the two polyolefin layers has a weight of 18 to 26 g/m2 and the other polyolefin layer has a weight of 12 to 16 g/m2 if it is the product contacting layer or 5 to 10 g/m2 if it is the paperboard contacting layer.

Helmet

A helmet is described, more specifically a helmet comprising a protective shell (10) formed of a flexible expanded polyurethane (EPU) material which defines a cavity for receiving the wearer's head, the shell being foldable, the helmet further comprising a strap (11) arrangement for fastening the shell to the wearer's head.

Casing for a watch

Microbial identification based on the overall composition of characteristic oligonucleotides

Identification of microorganisms based on the sequences of their 5S, 23S and particularly 16S ribosomal RNAs is growing in utility as the database of known ribosomal RNA sequences expands. Experimental identification is usually based on matching the experimentally-determined sequence of an organisms rRNA to a previously-determined sequence in the databank, or hybridization of the organisms rRNA or encoding rDNA to an oligonucleotide probe specific for an organism anticipated to be present in the sample. Here we propose the identification of microorganisms based on the overall composition (not sequence or hybridization propensity) of characteristic molecules derived from their rRNA or rDNA sequences by enzymatic cleavage or localized amplification. Ribonuclease T1 fragments of rRNA composition determination by mass spectrometry are especially favored. The characteristic molecules used can be chosen to be “compositional signatures” whose presence/absence is known to be associated with particular ...

Gas barrier packaging board

A paperboard structure having a five layer product side construction with an aliphatic gas barrier layer which is cost effective.

Process for producing glycolic acid from formaldehyde and hydrogen cyanide

A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.

Simplified ratchet strap and buckle assembly

Disclosed is a ratchet strap and buckle assembly comprising an adjustment ratchet strap comprising a ratchet strap end, and a plurality of ratchet teeth arranged thereon and a single-piece buckle having a locking tooth and a flexible top element, wherein the single-piece buckle comprises a passageway for the ratchet strap end to be inserted therein, and wherein the flexible top element is configured to engage with at least one of the plurality of ratchet teeth using the locking tooth upon insertion.

Casing for a watch

Method for the production of glycolic acid from ammonium glycolate by direct deammoniation

The present invention relates to a method for obtaining glycolic acid by direct deammoniation of ammonium glycolate. More specifically, water is removed from an aqueous solution of ammonium glycolate to produce the substantially anhydrous salt. Thermal salt cracking is then used to remove ammonia from the salt, producing a deammoniated product that is comprised of glycolic acid, oligomers of glycolic acid, ammonium salts of oligomers of glycolic acid, glycolamide, and unreacted ammonium glycolate. The deammoniated product can be further hydrolyzed to convert oligomers of glycolic acid to additional quantities of glycolic acid.

Timekeeping device

A timekeeping device comprising a housing; timekeeping functionality positioned within the housing and a clip assembly integrally coupled to the housing, wherein the clip assembly comprises a first member and a second member hingedly coupled to the first member at a hinge point, whereby pressure against the second member causes the second member to rotate relative to the first member about the hinge point to permit coupling of the timekeeping device to an object of interest. In a particular configuration, the second member is releasably engageable with the first member. Additionally, the housing may include a receptacle for receiving a casing within which the timekeeping functionality that maintains the timekeeping functions is disposed. Preferably, the housing and at least the first member are formed from a unitary mold, and preferably from plastic. The object of interest, for example, may be a backpack, beltloop or bicycle.

A Helmet

A helmet is described, more specifically a helmet comprising a protective shell () formed of a flexible expanded polyurethane (EPU) material which defines a cavity for receiving the wearer's head, the shell being foldable, the helmet further comprising a strap () arrangement for fastening the shell to the wearer's head. 1. A helmet comprising a protective shell comprising a flexible expanded polyurethane (EPU) material which defines a cavity for receiving a wearer's head , wherein said shell is foldable , and wherein said helmet further comprises a strap arrangement for fastening said shell to the wearer's head.2. (canceled)3. A helmet as claimed in claim 1 , wherein said shell comprises a plurality of different layers of EPU material having different densities or different compositions.4. A helmet as claimed in claim 3 , additionally comprising an outer polyurethane layer denser than said EPU layers; wherein said outer polyurethane layer is un-foamed claim 3 , or comprises a smooth skin claim 3 , or both.5. (canceled)6. A helmet as claimed in claim 4 , wherein said outer polyurethane layer is harder and thinner than any of said EPU layers.7. (canceled)8. A helmet as claimed in claim 1 , wherein the inner surface of said shell comprises fold lines to enable said shell to be folded; wherein the inner surface of said shell is defined as the surface of said shell located adjacent to the wearer's head when said helmet is fastened to the wearer's head.9. A helmet as claimed in claim 1 , wherein said EPU material is a composite material comprising a reinforcing material and expanded polyurethane.10. (canceled)11. A helmet as claimed in claim 1 , wherein said shell comprises a plurality of fingers extending radially from a locus; and wherein the distal ends of the fingers are arranged to be brought together to form said shell and to form the cavity for receiving the wearer's head.12. (canceled)13. (canceled)14. A helmet as claimed in claim 11 , wherein said shell comprises ...

Connector housing assembly having a pin protector plate

A connector assembly disclosed herein includes a male connector housing, female connector housing and a pin protector plate. The male connector housing includes a resilient finger having an engagement member spaced apart from an upper catch. The female connector housing includes a protruding member axially offset from a retention member. The pin protector plate is disposed between the male connector housing and the female connector housing and includes a tab and a peripheral catch. The tab projects upwardly from the base and is axially offset from the peripheral catch. The pin protector plate is movable from a locked position to a pre-stage position. Wherein the female connector housing is configured to move the pin protector in a pre-stage position when the female connector housing is removed. Accordingly, the male terminal blades remain protected during the servicing of the connector assembly.

ODOR ELIMINATING PORTABLE FORCED AIR FOOTWEAR DRYING APPARATUS

A portable, forced air footwear drying apparatus is disclosed, adapted to simultaneously dry a plurality of footwear, such as ski boots, with forced ambient air using one or more flexible tubes, a fan, and cedar insert. 1. A portable footwear drying device comprising:a housing defining a hollow recess of between 0.1 liters and 4 liters in volume, the housing enclosing a mechanical fan, the housing comprising one or more apertures for intaking ambient air, the housing comprising a plurality of apertures for gripping detachable tubes;a plurality of elongated, cylindrical, flexible, detachable tubes, the tubes detachably affixed to the housing at the apertures, the tubes each comprising a hollow body having an proximal end, a proximal opening for received pressurized air, a distal end and a distal opening for releasing pressurized air, the tubes between 6 centimeters and 6 meters in length; andone or more cedar wood insert(s) affixed to the housing for adding fragrance to ambient air exiting the mechanical fan.2. The portable footwear drying device of claim 1 , wherein the fan comprises an axial-flow fan.3. The portable footwear drying device of claim 1 , wherein the fan comprises a crossflow fan.4. The portable footwear drying device of claim 1 , wherein the fan comprises a centrifugal fan.5. The portable footwear drying device of claim 1 , further comprising a compressor affixed to the inside of the housing within the hollow recess.6. The portable footwear drying device of claim 1 , further comprising a heating element enclosed within the housing between the fan and the plurality of tubes.7. The portable footwear drying device of claim 1 , further comprising a heating element enclosed within one or more of the plurality of tubes.8. The portable footwear drying device of claim 1 , wherein the tubes are extrudable.9. The portable footwear drying device of claim 1 , wherein the housing is geometrically cubic in shape.10. The portable footwear drying device of claim 1 , ...

Gas barrier packaging board

A paperboard structure having gas barrier properties which is cost effective and durable. It uses linear low density polyethylene, metallocene-based linear low density polyethylene, or a blend of low density polyethylene and either linear low density polyethylene or metallocene-catalyzed linear low density polyethylene.

Fluid-Working Machine with Multi-Lobe Ring Cam

A fluid-working machine for a renewable energy generation device, the fluid-working machine comprising a ring cam and a plurality of working chambers, the ring cam having an annular working surface extending around an axis of rotation of the ring cam, the annular working surface defining a plurality of waves, each working chamber having a piston, each piston in operative engagement with the ring cam working surface, the ring cam and working chambers being mounted to rotate relative to each other, cycles of working chamber volume being thereby coupled to rotation of the ring cam relative to the working chambers, characterised in that the individual waves of the ring cam working surface have an asymmetric profile. 1. A wind energy system comprising a fluid-working machine with non-symmetric actuation acting as a transmission.2. A wind energy system according to claim 1 , wherein the fluid working machine further comprises working chambers that can be switched to a predetermined state.3. A wind energy system according to claim 2 , wherein the working chambers have valves that control a fluid traversing the working chambers.4. The wind energy system according to claim 1 , wherein the fluid working machine comprises a drive unit for receiving rotational movement and an output unit for delivering rotational movement.5. The wind energy system according to claim 3 , wherein each of the drive unit and the output unit comprise a plurality of working chambers.6. The wind energy system according to claim 1 , having a control unit to control a parameter selected from the group consisting of controlling the non symmetric actuation and switching off of working chambers.7. The wind energy system according to having working chamber disabling means for temporarily switching the working chambers to a predetermined state.8. The wind energy system according to claim 1 , wherein the fluid working machine has a cam for moving pistons of the fluid working machine.9. The wind energy system ...

VARIABLE DISPLACEMENT RADIAL PISTON FLUID WORKING MACHINE

A variable displacement fluid working machine includes an inward ring and an outward ring, one of the inward ring and the outward ring including a rotatable ring cam coupled to a drive shaft, the other including a plurality of radially extending piston cylinders circumferentially spaced around the respective ring. The outward ring has first and second axially spaced structural members and a plurality of demountable blocks demountably retainable therebetween, the demountable blocks having either piston cylinders or ring cam segments. The demountable blocks are removable radially to facilitate maintenance and repair and to facilitate radial access to the inward ring. 1. A variable displacement radial piston fluid working machine , the fluid working machine comprising:an inward ring and an outward ring around the inward ring;one of the inward ring and the outward ring comprising a rotatable ring cam, the other comprising a plurality of radially extending cylinders circumferentially spaced around the respective ring, each cylinder having a piston reciprocably mounted therein;a drive shaft coupled to the ring cam;the outward ring comprising first and second axially spaced structural members and a plurality of demountable blocks demountably retainable therebetween, each of the plurality of demountable blocks comprising either at least some of the said plurality of cylinders or a segment of the ring cam respectively, each said block being mountable to locate one or more said cylinders in opposing relation to a portion of the ring cam to enable the pistons to be driven by the ring cam and demountable to expose the inward ring for access.2. A variable displacement radial piston fluid working machine as claimed in claim 1 , wherein the demountable blocks are individually demountable.3. A variable displacement radial piston fluid working machine as claimed in claim 1 , wherein the demountable blocks are demountable by radially outwards motion.4. A variable displacement radial ...

TERMINAL AND CONNECTOR ASSEMBLY

A connector assembly is provided with a body that extends along a lateral length with a longitudinal height defined by a first body surface and an opposing second body surface. A locking terminal extends through the body and includes an elongate blade having a distal end for electrically connecting to a mating connector and a proximal end adapted to electrically connect to an electronic component with an aperture. At least one tab extends lengthwise from an intermediate portion of the blade and extends through the electronic component aperture. A projection extends outward from the tab such that the projection interferes with the aperture during insertion of the tab therethrough for deforming the tab. After insertion, the tab returns from the deformation and engages the projection to the electronic component for retaining the tab within the aperture. 1. A terminal comprising:an elongate blade having a distal end for electrically connecting to a mating connector and a proximal end adapted to electrically connect to a circuit board with an aperture;at least one tab extending lengthwise from an intermediate portion of the blade for extending through the circuit board aperture; anda projection extending outward from the tab such that the projection interferes with the circuit board aperture during insertion of the tab therethrough for deforming the tab, such that after insertion the tab returns from the deformation thereby engaging the projection to the circuit board and thereby retaining the tab within the aperture.2. The terminal of wherein the tab is laterally spaced apart from the circuit board after insertion for limiting residual loads applied to the circuit board by the terminal.3. The terminal of wherein the projection engages an underside of the circuit board after insertion of the tab for maintaining a longitudinal position of the terminal relative to the circuit board.4. The terminal of wherein the blade comprises a first surface and a laterally spaced apart ...

FLUID-WORKING MACHINE WITH MULTI-LOBE RING CAM

A fluid-working machine for a renewable energy generation device, the fluid-working machine comprising a ring cam and a plurality of working chambers, the ring cam having an annular working surface extending around an axis of rotation of the ring cam, the annular working surface defining a plurality of waves, each working chamber having a piston, each piston in operative engagement with the ring cam working surface, the ring cam and working chambers being mounted to rotate relative to each other, cycles of working chamber volume being thereby coupled to rotation of the ring cam relative to the working chambers, characterised in that the individual waves of the ring cam working surface have an asymmetric profile. 1. A fluid-working machine for a renewable energy generation device , the fluid-working machine comprising a ring cam and a plurality of working chambers , the ring cam having an annular working surface extending around an axis of rotation of the ring cam , the annular working surface defining a plurality of waves , each working chamber having a piston , each piston in operative engagement with the ring cam working surface , the ring cam and working chambers being mounted to rotate relative to each other , cycles of working chamber volume being thereby coupled to rotation of the ring cam relative to the working chambers , characterised in that the individual waves of the ring cam working surface have an asymmetric profile.2. A fluid-working machine wherein the profile of the plurality of waves are the same as each other and the working surface is rotationally symmetric.3. A fluid-working machine according to or , wherein the fluid-working machine has a first operating mode and a second operating mode in which the ring cam rotates in the opposite sense relative to the working chambers.4. A fluid-working machine according to claim 3 , wherein the machine operates more efficiently or has a longer expected operating lifetime in the first operating mode than the ...

Contaminant control in zymomonas fermentation using hop acids

Contamination was controlled in fermentations using Zymomonas mobilis as the biocatalyst, without negative impact on fermentation production, by the addition of hop acids. The effective concentration of hop acids was found to be dependent upon the type of fermentation medium used.

Compositions, processes and algorithms for microbial detection

Processes for identifying whether any parasite or other organism is present in a host comprising: a. scanning for non-host signatures, b. scanning for one-error-removed non-host signatures; c. scanning for N-error removed non-host signatures; where N is selected to give the desired statistical certainty of the presence or absence of any parasite in the host. Algorithms useful for such detections and listings of specific signatures” (sequences or subsequences) for identifying specific microorganisms are also both provided.

PRESS FIT ELECTRICAL TERMINAL HAVING A SOLDER TAB SHORTER THAN PCB THICKNESS AND METHOD OF USING SAME

A circuit board assembly may include a circuit board, a first electrical terminal, and a layer of solder paste. The circuit board may include a minimum thickness, a first side, and a second side opposite the first side. The first electrical terminal may include a solder tab. The layer of solder paste may be disposed on the first side of the circuit board. The solder tab of the first electrical terminal may extend into the first side of the circuit board but not beyond the second side of the circuit board. 1. A circuit board assembly comprising:a circuit board;a first electrical terminal; anda layer of solder paste;wherein the circuit board includes a minimum thickness, a first side, and a second side opposite the first side; the first electrical terminal includes a solder tab; and the layer of solder paste is disposed on the first side of the circuit board and the solder tab of the first electrical terminal extends into the first side of the circuit board but not beyond the second side of the circuit board.210. The circuit board assembly of claim , wherein said solder tab extends short of the second side of the circuit board.312. The circuit board assembly of claim , comprising:a second layer of solder paste; anda second electrical terminal,wherein the second electrical terminal includes a solder tab; and the second layer of solder paste is disposed on the second side of the circuit board and the solder tab of the second electrical terminal extends into the second side of the circuit board but short of the first side of the circuit board.413. The circuit board assembly of claim , wherein the solder tab of the first electrical terminal and the solder tab of the second electrical terminal each extend at least 75% through the circuit board.512. The circuit board assembly of claim , wherein the first electrical terminal includes a second solder tab , and the second solder tab extends into the first side of the circuit board but does not extend beyond the second side of ...

PRESS FIT ELECTRICAL TERMINAL HAVING A SOLDER TAB SHORTER THAN PCB THICKNESS AND METHOD OF USING SAME

A method of assembling a circuit board may include inserting a first electrical terminal into a first side of a circuit board, and applying a second layer of solder paste to a second side of the circuit board, the second side disposed opposite of the first side. The first electrical terminal may include a solder tab, a maximum length of the solder tab may be shorter than a minimum thickness of the circuit board, and if the first electrical terminal is inserted into the circuit board, the solder tab may extend at least partially into the circuit board without extending entirely through the circuit board. One or more electrical terminals with short and/or long solder tabs may be inserted into the second side of the circuit board and/or one or more electrical components may be attached to second side of circuit board. 1. A method of assembling a circuit board , the method comprising:inserting a solder tab of a first electrical terminal into a first side of the circuit board; andapplying a layer of solder paste to a second side of the circuit board, the second side disposed opposite of the first side;wherein the solder tab extends no further than the second side of the circuit board.2. The method of claim 1 , wherein the solder tab extends short of the second side of the circuit board.3. The method of claim 2 , comprising applying an initial layer of solder paste to the first side of the circuit board before inserting the solder tab into the first side of the circuit board.4. The method of claim 3 , comprising heating the initial layer of solder paste to fix the first electrical terminal relative to the circuit board before applying the layer of solder paste to the second side of the circuit board.5. The method of claim 2 , comprising:inserting a solder tab of a second electrical terminal into the second side of the circuit board; andheating the layer of solder paste to fix the first electrical terminal and the second electrical terminal relative to the circuit board.6. ...

Printed Circuit Board Assembly Having Improved Terminals

A printed circuit board (PCB) assembly includes a printed circuit board and first and second electrical terminals mounted thereto. The first electrical terminal comprises a body having a first end and a second end, a mounting member extending outwardly from the first end configured for insertion into an aperture formed in the PCB, shoulders defined adjacent the mounting member, and a first insertion tab extending outwardly from the body at the first end thereof. The second electrical terminal is mounted adjacent the first electrical terminal and comprises a body having a first end and a second end, a mounting portion extending outwardly from the first end configured for insertion into an aperture formed in the PCB, shoulders defined adjacent the mounting portion, and a second insertion tab extending outwardly from the body at the first end thereof. The first insertion tab and the second insertion tab are axially spaced apart. 1. A printed circuit board (PCB) assembly comprising:a printed circuit board;a first electrical terminal mounted to the PCB, the first electrical terminal comprising a body having a first end and a second end, a mounting member extending outwardly from the first end configured for insertion into an aperture formed in the PCB, shoulders defined adjacent the mounting member, and a first insertion tab extending outwardly from the body at the first end thereof; anda second electrical terminal mounted to the PCB adjacent the first electrical terminal, the second electrical terminal comprising a body having a first end and a second end, a mounting portion extending outwardly from the first end configured for insertion into an aperture formed in the PCB, shoulders defined adjacent the mounting portion, and a second insertion tab extending outwardly from the body at the first end thereof;wherein the first insertion tab and the second insertion tab are axially spaced apart.2. The PCB assembly according to claim 1 , wherein the first insertion tab ...

RNA pores and methods and compositions for making and using same

Synthetic RNA molecules having a pore, compositions including RNA molecules having a pore, where the compositions are capable of filtering metal ions, filtering molecular ions, performing size exclusion chromatography, performing ion specific chromatography, reversible metal ion and molecular ion binding, ion selective membranes, ion selective channels, ion selective/specific sensors, electrical conduits, battery components, etc., and devices and methods for making and using same. The RNAs used may be modified to improve stability. For example, by for example, a methyl group may be attached to the 2′ OH of the ribose. 17-. (canceled)8. A filter comprising one or more RNA molecules having at least one pore wherein the RNA molecule(s) are attached to a support.9. The filter of wherein the support is a selected from the group consisting of a film claim 8 , beads claim 8 , glass slides claim 8 , metal surfaces claim 8 , surfaces coated with antibodies claim 8 , surfaces coated with cells claim 8 , hydrogel surfaces claim 8 , nitrocellulose surfaces claim 8 , polymeric surfaces claim 8 , plastic surfaces claim 8 , ceramic surfaces silicon dioxide surfaces and surfaces coated with proteins claim 8 , peptides claim 8 , amino acids claim 8 , carbohydrates and/or nucleic acids.1017-. (canceled)18. The RNA molecule of wherein the molecule has catalytic activity.19. The RNA molecule of wherein the molecule has catalytic activity selected from the activities consisting of reductase claim 18 , transferase claim 18 , hydrolase claim 18 , lyase claim 18 , isomerase and ligase activity.20. The RNA molecule of wherein the molecule contains from 1 to 10 claim 8 ,000 pores.21. The RNA molecule of wherein the molecule contains from 10 to 10 claim 8 ,000 pores. The present application is a non-provisional application which claims benefit under 35 USC §119(e) of the U.S. Provisional Ser. No. 61/704,002 filed Sep. 21, 2012.Embodiments of the present invention relate to synthetic RNA ...

Semi-compliant terminals

The present disclosure includes an electrical terminal that may include a first portion, a second portion, and/or a middle portion. A middle portion may be disposed between first and second portions and/or a middle portion may include a first middle section, a second middle section, a recessed portion disposed between the first middle section and the second middle section, and/or an aperture. The electrical terminal may include a transition portion that may be disposed between a middle portion and a second portion.

METHODS OF PRODUCING PATIENT-SPECIFIC ANTI-CANCER THERAPEUTICS AND METHODS OF TREATMENT THEREFOR

A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs. 1. A method of preparing an antibody therapeutic comprising:a. providing a dissociated cell sample from at least one solid tumor sample obtained from a patient;b. loading the dissociated cell sample into a microfluidic device having at least one flow region and at least one isolation region fluidically connected to the flow region;c. moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; andd. identifying at least one isolated B cell that produces antibodies capable of binding to a cancer cell-associated antigen.2. The method of claim 1 , wherein said isolation region comprises at least one conditioned surface that promotes B cell lymphocyte viability claim 1 , said conditioned surface comprising covalently linked molecules claim 1 , wherein said covalently linked molecules comprise alkylene ether moieties claim 1 , amino acid moieties claim 1 , saccharide moieties claim 1 , or any combination thereof.3. (canceled)4. The method of claim 2 , wherein said at least one conditioned ...

Genetic Affinity of Microorganisms and Viruses

Selecting which sub-sequences in a database of nucleic acid such as 16S rRNA are highly characteristic of particular groupings of bacteria, microorganisms, fungi, etc. on a substantially phylogenetic tree. Also applicable to viruses comprising viral genomic RNA or DNA. A catalogue of highly characteristic sequences identified by this method is assembled to establish the genetic identity of an unknown organism. The characteristic sequences are used to design nucleic acid hybridization probes that include the characteristic sequence or its complement, or are derived from one or more characteristic sequences. A plurality of these characteristic sequences is used in hybridization to determine the phylogenetic tree position of the organism(s) in a sample. Those target organisms represented in the original sequence database and sufficient characteristic sequences can identify to the species or subspecies level. Oligonucleotide arrays of many probes are especially preferred. A hybridization signal can comprise fluorescence, chemiluminescence, or isotopic labeling, etc.; or sequences in a sample can be detected by direct means, e.g. mass spectrometry. The method's characteristic sequences can also be used to design specific PCR primers. The method uniquely identifies the phylogenetic affinity of an unknown organism without requiring prior knowledge of what is present in the sample. Even if the organism has not been previously encountered, the method still provides useful information about which phylogenetic tree bifurcation nodes encompass the organism.

HYDRAULIC POWER SYSTEM

A hydraulic actuation system includes a differential unit having a hydraulically-actuated differential, a power steering unit, a hydraulic pump, a reservoir, a controller, an electronically-controlled flow control manifold, and a proportional pressure control solenoid valve. A flow control manifold may control fluid flow to the power steering unit and the differential. The manifold may include a manifold inlet connected to a pump; first manifold outlet connected to a differential; second manifold outlet connected to a reservoir; third manifold outlet connected to a power steering unit; two-way solenoid valve connected to a manifold inlet and controlled by a controller; flow control valve connected to a two-way solenoid valve and a first manifold outlet; and a pressure differential sensing valve connected to a two-way solenoid valve, the manifold inlet, and the third manifold outlet. A proportional pressure control solenoid valve may connect the first manifold outlet and the differential. 1. A hydraulic actuation system comprising:a differential unit including a hydraulically-actuated differential;a power steering unit;a hydraulic pump;a reservoir;a controller; a manifold inlet connected to the pump,', 'a first manifold outlet connected to the hydraulically-actuated differential,', 'a second manifold outlet connected to the reservoir,', 'a third manifold outlet connected to the power steering unit,', 'a two-way solenoid valve connected to the manifold inlet and controlled by the controller,', 'a flow control valve connected to the two-way solenoid valve and the first manifold outlet, and', 'a pressure differential sensing valve connected to the two-way solenoid valve, the manifold inlet, and the third manifold outlet; and,, 'an electronically-controlled flow control manifold configured to control fluid flow to the power steering unit and the hydraulically-actuated differential, the manifold including'}a proportional pressure control solenoid valve connected to the ...

Methods of Producing Patient-Specific Anti-Cancer Therapeutics and Methods of Treatment Therefor

A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs. 1. A method of identifying an isolated B cell that produces antibodies capable of binding to a cancer cell-associated antigen comprising:loading a dissociated cell sample from at least one solid tumor sample obtained from a patient into a microfluidic device having at least one flow region and at least one sequestration chamber comprising an isolation region, wherein the isolation region is fluidically connected to the flow region;moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; andidentifying at least one isolated B cell that produces antibodies capable of binding to a cancer cell-associated antigen.217-. (canceled)18. The method of claim 1 , wherein moving the at least one B cell into the at least one isolation region comprises using DEP force to move the at least one B cell.19. The method of claim 1 , wherein the at least one B cell is moved into the at least one isolation region using gravity and/or localized fluid flow.2022-. (canceled)23. The method of claim 1 , ...

Ring cam ensuring smooth follower handover between segments

A ring cam for a fluid-working machine comprises plural segments 5, 7 having piston facing surfaces 15, 16 together defining a working surface. The segments comprise leading and trailing end cooperating formations each having a potion of the working surface, which each inter-engage with respective adjacent formations and which are recessed from the working surface towards their respective ends or cross at less than 180 degrees. The cooperating formations interlock and rollers are thereby handed over smoothly from one segment to the next irrespective of slight variations in alignment due to manufacturing tolerance or wear. The segment piston facing surfaces are placed in compressive stress to partially or fully compensate for tensile stress arising from the action of rollers in use. The segments form a wavelike cam surface and attachment means 3 are provided, through the working surface on whichever of the leading 70 or trailing 72 surfaces thereof is subject to lowest forces from pistons in use.

Fluid-working machine with multi-lobe ring cam

A fluid-working machine for a renewable energy generation device, the fluid-working machine comprising a ring cam and a plurality of working chambers, the ring cam having an annular working surface extending around an axis of rotation of the ring cam, the annular working surface defining a plurality of waves, each working chamber having a piston, each piston in operative engagement with the ring cam working surface, the ring cam and working chambers being mounted to rotate relative to each other, cycles of working chamber volume being thereby coupled to rotation of the ring cam relative to the working chambers, characterised in that the individual waves of the ring cam working surface have an asymmetric profile.

Electric pyrography and thermo-cautery appliance

Thermoplastic applicator exhibiting accelerated breakup when immersed in water

A thermoplastic applicator is disclosed which exhibits accelerated breakup when immersed in water. The applicator includes a hollow, cylindrically shaped member which holds a pledget. This cylindrically shaped member is constructed of a water-soluble or water-dispersible material and has a wall with a thickness of less than about .05 inches (about 12.7 mm). A plurality of grooves are formed in the wall in a predetermined pattern to accelerate breakup of the applicator into small unrecognizable pieces. The grooves have a depth of between about 5 percent to 75 percent of the thickness of the wall. The deeper the grooves, the shorter the time period needed to breakup the applicator.

Electrical connector

The connector assembly includes a body extending along a length with a longitudinal height defined by a first surface and an opposing second surface. At least one terminal projects through the body. The terminal includes a blade extending from the first surface for electrically connecting with a mating connector. The terminal also includes a leg extending from the second surface. A tab has a convex surface and is formed at a distal end of the leg without any apertures formed therethrough. The convex surface is adapted for electrically connecting with a mounting surface of an electronic component upon receipt of a predetermined signal.

Fluid-working machine with asymmetrically profiled multi-lobe ring cam

A fluid-working machine for a renewable energy generation device e.g. a wind turbine comprises a ring cam 307 and working chambers 303. The ring cam, which may be segmented, having an annular working surface around an axis of rotation and defining a plurality of waves. Each working chamber may be canted from a radial line and has a piston engaged with the working surface to reciprocate as the ring cam and working chambers relatively rotate. The individual waves of the ring cam working surface have an asymmetric profile about a peak or a trough but the ring cam may be rotationally symmetrical. The machine may operate in both a motoring and dominant pumping modes and the cam profile may give a longer exhaust stroke than an inlet stroke in the dominant mode to reduce working face slope relative to a breathing face slope and minimize Hertzian stress and piston side loads.

Ring cam and fluid-working machine including ring cam

Locking screw-threaded members

1,032,207. Producing locking nuts. NUTS & BOLTS (DARLASTON) Ltd. Feb. 22, 1965 [Feb. 28, 1964], No. 42977/63. Heading B3A. [Also in Division F2] An insert 16 is positioned within a groove 11 in the threaded bore 13 of a self-locking nut, for example, by means of opposed cylindrical dies 13 and 14 which are forced together. The insert 16, suitably of nylon which can be heated if desired, is forced into the annular groove and retained there. The nut is subsequently mounted on a spring support 21 (Fig. 3, not shown), a circular die 23 forcing the nut downwardly over a cutting die 17 to remove the centre section of the insert. In place of a single groove, a number of discontinuous grooves may be provided, and the threads in the nut on opposite sides of the groove or grooves may be slightly misaligned.

A helmet

A helmet is described, more specifically a helmet comprising a protective shell (10) formed of a flexible expanded polyurethane (EPU) material which defines a cavity for receiving the wearer's head, the shell being foldable, the helmet further comprising a strap (11) arrangement for fastening the shell to the wearer's head.

Tampon having a resilient member

A tampon is disclosed which is useful in preventing premature leakage of body fluid from a woman's vagina especially during her menstrual period. The tampon includes an absorbent and a resilient member. The resilient member is positioned on or within the absorbent and both members are rolled or formed into an elongated softwind having a first end and a second end. The softwind is folded upon itself such that the first and second ends are aligned adjacent to one another and the softwind contains at least two folds therebetween. The softwind is compressed into an elongated pledget having an insertion end and a trailing end. The resilient member is capable of expanding at least a portion of the pledget so as to prevent premature leakage of body fluid when inserted into a woman's vagina. The tampon further includes a withdrawal string for removing the tampon from a woman's vagina. The withdrawal string is attached to the first and second ends of the softwind.

Synergistic combination of xolair/omalizumab/e25 with immunosuppressive agent

The present invention provides a pharmaceutical composition comprising an Anti-lgE Antibody and at least one further immunosuppressive agent, in which the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier; for simultaneous, separate or sequential use.

Safety means to prevent edgewise separation of door and jamb

Self-contained hydraulic torque modulating device

A torque modulating coupling device for operatively linking two shafts has a clutch and a piston disposed in a case. The piston selectively applies force to the clutch in response to hydraulic pressure, and a keyed feature adapted to couple with a corresponding keyed feature associated with at least one of the shafts. The coupling device can be formed with two cases that form an enclosure for the clutch and the piston, trapping the piston forces between the cases. This embodiment allows the device to also act as an axle housing cover. In another embodiment, the case is designed to bolt directly to an axle housing cover, trapping piston forces between the case and the cover.

Armored telephone cord with a longitudinal strength member

ARMORED TELEPHONE CORD WITH A LONGITUDINAL STRENGTH MEMBER Abstract An armored cord has flexibility and tensile strength for securing a telephone handset to a telephone housing. The cord includes an outer armored sheath which is designed for increased flexibility in that it allows the cord to bend readily over small radii. Tensile strength between the handset and housing is provided by an internal cable which absorbs the stress applied to the cord when subjected to unusually large longitudinal forces. The service life of the cord is lengthened, and the number of incidents causing out-of-service conditions is thereby reduced.

Shoe.

Tampon having a resilient member and a method of forming the tampon

A tampon is disclosed which is useful in preventing premature leakage of body fluid from a woman's vagina especially during her menstrual period. The tampon includes an absorbent and a resilient member. The resilient member is positioned on or within the absorbent and both members are rolled or formed into an elongated softwind having a first end and a second end. The softwind is folded upon itself such that the first and second ends are aligned adjacent to one another and the softwind contains at least two folds therebetween. The softwind is compressed into an elongated pledget having an insertion end and a trailing end. The resilient member is capable of expanding at least a portion of the pledget so as to prevent premature leakage of body fluid when inserted into a woman's vagina. The tampon further includes a withdrawal string for removing the tampon from a woman's vagina. The withdrawal string is attached to the first and second ends of the softwind. The method includes the steps of assembling a resilient member and an absorbent to form a structure having a central longitudinal axis X--X. The resilient member can be either aligned with or offset from the central longitudinal axis X--X. The absorbent and the resilient member are rolled or folded up into an elongated softwind which has a first end and a second end. The softwind is folded upon itself such that the first and second ends are aligned adjacent to one another and the softwind contains at least two folds therebetween. The softwind is then compressed into a pledget having an insertion end and a trailing end. A withdrawal string is secured to the pledget to form a tampon. The withdrawal string facilitates removal of the tampon from the woman's vagina.

Curved tampon applicator having an improved fingergrip

A curved tampon applicator is disclosed having an improved fingergrip for preventing rotation of the applicator during insertion of a catamenial tampon into a woman's vagina. The applicator (10) includes a tubular member (16) having an arcuate shape with a centerline (A--A) formed on an arc having a predetermined radius of curvature. The tubular member has a stepped outer profile with an enlarged portion (18) designed to house a tampon (12) joined to a smaller fingergrip portion (20). The tubular member has a forward end (22) through which the tampon is ejected and a rearward end (24) through which a plunger (40) is slidable. The fingergrip portion has a passageway (38) formed therethrough which is sized and configured to receive the plunger and an exterior periphery (34). Formed on the exterior periphery of the fingergrip portion are first and second pairs of flat surfaces. The first pair (52, 54) of the flat surfaces is aligned parallel to a plane coincident with a radius forming the arcuate centerline of the tubular member and the second pair (56, 58) of flat surfaces is aligned perpendicular to the first pair of flat surfaces. The fingergrip portion also contains a plurality of spaced apart ribs (68), each of which completely surrounds the exterior periphery. The ribs cooperate with the first and second pairs of flat surfaces to prevent rotation of the curved tampon applicator during insertion of a tampon into a woman's vagina.

COMBINATION OF XOLAIR WITH IMMUNOSUPPRESSOR AGENT

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN ANTICUERPO ANTI-IgE (OMALIZUMAB); B) UN AGENTE INMUNOSUPRESOR SELECCIONADO ENTRE CICLOSPORINA A, AZATIOPRINA, ANTI-IL-8, ADALIMUNAB, HU5C8, OKT3, ENLIMONAB, ENTRE OTROS LOS CUALES SE CARACTERIZAN POR INHIBIR LA ACTIVACION DE LAS CELULAS-T POR CUANDO MENOS DEL 10% . DICHA COMPOSICION INHIBE LA RESPUESTA INMUNE EN EL TRATAMIENTO DE ENFERMEDADES ALERGICAS TALES COMO ASMA ALERGICO, DERMATITIS ATOPICA, ENFERMEDAD PULMONAR OBSTRUCTIVA, ENTRE OTROS IT REFERS TO A PHARMACEUTICAL COMPOSITION INCLUDING: A) AN ANTI-IgE ANTIBODY (OMALIZUMAB); B) AN IMMUNOSUPPRESSOR AGENT SELECTED AMONG CYCLOSPORIN A, AZATHIOPRINE, ANTI-IL-8, ADALIMUNAB, HU5C8, OKT3, ENLIMONAB, AMONG OTHERS WHICH ARE CHARACTERIZED BY INHIBITING THE ACTIVATION OF THE MINUS-T CELLS PER WHEN 10% T-CELLS. SUCH COMPOSITION INHIBITS THE IMMUNE RESPONSE IN THE TREATMENT OF ALLERGIC DISEASES SUCH AS ALLERGIC ASTHMA, ATOPIC DERMATITIS, OBSTRUCTIVE PULMONARY DISEASE, AMONG OTHERS

Printed circuit board assembly having improved terminals

A printed circuit board includes a surface and having first and second adjacent apertures. First and second electrical terminals include respective ends disposed in the first and second apertures of the printed circuit board, respective shoulders adjacent to the ends of the first and second electrical terminals and engaged with the surface of the printed circuit board, and respective insertion tabs adjacent to the shoulders of the first and second electrical terminals and located respective first and second distances away from the surface of the printed circuit board. The first and second distances are different such that the first and second insertion tabs do not touch one another.

Electric device for heating liquids

Thermoplastic hygienic accelerator with accelerated fragmentation when immersed in water.

L'applicateur comprend: a) un premier élément (14) conçu pour retenir un tampon, ledit élément étant fait d'un matériau thermoplastique hydrodispersable et ayant une paroi mince (26), ledit élément (14) ayant une périphérie intérieure et une périphérie extérieure (34); et b) une série de gorge (36) formée dans ladite paroi (26) pour accélérer la fragmentation dudit premier élément (14) lorsque ledit applicateur est immergé dans l'eau, lesdites gorges (36) ayant une profondeur comprise entre environ 5 % et 75 % de l'épaisseur de ladite paroi. The applicator comprises: a) a first member (14) adapted to retain a tampon, said member being made of a water-dispersible thermoplastic material and having a thin wall (26), said member (14) having an inner periphery and a periphery exterior (34); and b) a series of grooves (36) formed in said wall (26) for accelerating fragmentation of said first member (14) when said applicator is submerged in water, said grooves (36) having a depth of between about 5% and 75% of the thickness of said wall.

Method for the manufacture of desulphurisation agents

Method of desulphurizing a ferrous melt comprises injecting into the melt lime-containing particles having smooth surfaces, a low tendency to absorb moisture and blocked pores formed by solidification of molten inorganic matter in the pores of the lime. Method of making a desulphurization agent for the desulphurizing method comprises calcining limestone with, for example, sodium carbonate, calcium fluoride or siliceous matter. Desulphurization agents per se are also described.

Process for producing glycolic acid from formaldehyde and hydrogen cyanide

A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.

Mixers

Hygienic thermoplastic applicator with accelerated fragmentation when immersed in water.

Free floating hydraulic bulkhead with improved sealing and anti-rotation

A hydraulic bulkhead configured for use with a limited slip differential includes a plenum comprising a passageway for hydraulic fluid and a boss. A first seal is located on an outer surface of the boss. The outer surface of the boss is a low pressure area relative to the inner surface of the boss. The plenum is stationary relative to the limited slip differential. A differential assembly including the inventive hydraulic bulkhead is also disclosed.

Method of forming a tampon having a resilient member

A method of forming a catamenial tampon is disclosed wherein the tampon is useful in preventing premature leakage of body fluid from a woman's vagina and in providing better utilization of the absorbent during use. The method includes the steps of assembling a resilient member and an absorbent to form a structure having a central longitudinal axis X--X. The resilient member can be either aligned with or offset from the central longitudinal axis X--X. The absorbent and the resilient member are rolled or folded up into an elongated softwind which has a first end and a second end. The softwind is folded upon itself such that the first and second ends are aligned adjacent to one another and the softwind contains at least two folds therebetween. The softwind is then compressed into a pledget having an insertion end and a trailing end. A withdrawal string is secured to the pledget to form a tampon. The withdrawal string facilitates removal of the tampon from the woman's vagina.

Plunger sash-weight-molding apparatus

Method and apparatus for isolating and identifying periodic doppler signals

An improved method and apparatus for detecting and identifying one or more resonantly vibrating blades (14) of a turbine (12) through the use of acoustic sensors (10) imbedded in the stationary casing of the turbine (12) is disclosed. The acoustic sensor signals (11) are processed to separate the characteristic Doppler waveform from the accompanying random noise and periodic noise. Improved signal processing techniques which involve the evaluation of both an information-bearing resonant signal and its Hilbert transform via direct synthesis are disclosed.

A helmet

Measuring plutonium concentration in process liquid streams

Apparatus and method for measuring the concentration of plutonium in a process liquid stream at the plutonium product stage in irradiated fuel reprocessing plant. The method consists of neutron coincidence counting to measure the inherent neutron emission from spontaneous fission of 'even' mass Pu isotopes, measuring the additional neutrons from fissions induced in the fissile 'odd' mass isotopes by the presence of an external neutron source, and employing a conversion factor determined from the ratio of these measurements to convert either one of them into total Pu concentration. Apparatus for performing the said method comprises an annular container for liquid from said process liquid stream, neutron counters 5 arranged around the container 1, and a neutron source 4 withdrawable from and movable into an axial position relative to the container 1 by a ram or cable 8. <IMAGE>

Curved catamenial tampon applicator with an improved finger grip portion.

L'applicateur comprend un tube extérieur (16) arqué ayant une portion agrandie (18), conçue pour recevoir un tampon (12), réunie à une portion plus petite de préhension digitale (20), dont la périphérie extérieure (34) comporte une première paire de surfaces plates (52) parallèles entre elles et une seconde paire de surfaces plates (56, 58) perpendiculaires à ladite première paire de surfaces plates (52, 54). Ces paires de surfaces plates offrent à l'utilisatrice différentes possibilités de saisie et empêchent que le tube extérieur puisse tourner pendant l'insertion du tampon dans le vagin. The applicator comprises an arcuate outer tube (16) having an enlarged portion (18), adapted to receive a tampon (12), joined to a smaller finger grip portion (20), the outer periphery (34) of which has a first pair of flat surfaces (52) parallel to each other and a second pair of flat surfaces (56, 58) perpendicular to said first pair of flat surfaces (52, 54). These pairs of flat surfaces provide the user with different grip options and prevent the outer tube from rotating during insertion of the tampon into the vagina.

Fluid-working machine with multi-lobe ring cam

A fluid-working machine for a renewable energy generation device, the fluid-working machine comprising a ring cam and a plurality of working chambers, the ring cam having an annular working surface extending around an axis of rotation of the ring cam, the annular working surface defining a plurality of waves, each working chamber having a piston, each piston in operative engagement with the ring cam working surface, the ring cam and working chambers being mounted to rotate relative to each other, cycles of working chamber volume being thereby coupled to rotation of the ring cam relative to the working chambers, characterised in that the individual waves of the ring cam working surface have an asymmetric profile.

Tampon having a resilient member and a method of forming the tampon

A tampon is disclosed which is useful in preventing premature leakage of body fluid from a woman's vagina especially during her menstrual period. The tampon includes an absorbent and a resilient member. The resilient member is positioned on or within the absorbent and both members are rolled or formed into an elongated softwind having a first end and a second end. The softwind is folded upon itself such that the first and second ends are aligned adjacent to one another and the softwind contains at least two folds therebetween. The softwind is compressed into an elongated pledget having an insertion end and a trailing end. The resilient member is capable of expanding at least a portion of the pledget so as to prevent premature leakage of body fluid when inserted into a woman's vagina. The tampon further includes a withdrawal string for removing the tampon from a woman's vagina. The withdrawal string is attached to the first and second ends of the softwind. A method of forming a tampon is also disclosed.

Tampon applicator

A tampon applicator is disclosed which includes first and second telescopically assembled members. The first member is designed to house an absorbent tampon. The first member has first and second spaced apart ends and is formed from at least two separate and distincts layers. An insertion tip is integrally formed on the first end of the first member and extends outwardly therefrom. The insertion tip is constructed from at least one of the two distinct layers and has a thickness which is less than that of the first member. The second member is telescopically mounted in the second end of the first member and is adapted to expel the tampon through the insertion tip as it is pushed into the first member. An apparatus and method are also disclosed for crimping, pleating and forming a tip on a hollow tube.

electronically driven locking differential

resumo “diferencial de travamento acionado eletronicamente” trata-se de um diferencial de travamento acionado eletronicamente para um veículo automotivo que inclui uma caixa de engrenagens, um par de engrenagens laterais dispostas dentro da caixa de engrenagens e adaptadas operativamente para a rotação com um par de semieixos correspondentes, e uma placa de travamento disposta dentro da caixa de engrenagens e associada operacionalmente com uma das engrenagens laterais e axialmente móvel em relação a uma das engrenagens laterais. o diferencial de travamento acionado eletronicamente também inclui uma mola de retorno disposta dentro da caixa de engrenagens e que coopera com a placa de travamento para impelir axialmente a placa de travamento a se afastar de uma das engrenagens laterais e um atuador eletrônico que coopera com a placa de travamento, onde o atuador eletrônico tem um estator não rotativo disposto próximo a uma parte da caixa de engrenagens, uma bobina eletromagnética associada com o estator, e uma armadura não rotativa acoplada à placa de travamento e axialmente móvel em relação ao estator. 1/1 abstract electronically actuated locking differential is an electronically actuated locking differential for an automotive vehicle that includes a gearbox, a pair of side gears arranged within the gearbox and operatively adapted for rotation with a pair of corresponding semi-shafts, and a locking plate disposed within the gearbox and operatively associated with one of the side gears and axially movable with respect to one of the side gears. the electronically actuated locking differential also includes a return spring disposed within the gearbox and cooperating with the locking plate to axially urge the locking plate away from one of the side gears and an electronic actuator cooperating with the plate where the electronic actuator has a non-rotating stator disposed next to a part of the gearbox, an electromagnetic coil associated with the stator, and a non-rotating ...

Hydraulic coupling having self-adjusting anti-rotation hydraulic fluid path

A hydraulic coupling (10) for use in a vehicle drive train having a fluid path (48) which extends between the housing (12) of the hydraulic coupling (10) and a coupling mechanism (30). The fluid path (48) includes a first aperture (50) formed in the housing (12) with a first diameter and a longitudinal axis (A), as well as a second aperture (52) formed in the coupling mechanism (30). A rigid conduit (54) extends between the first and second apertures (50, 52) with a first portion having a diameter that is less than the first diameter of the first aperture (50) so as to define an adjustment gap (G) that allows the rigid conduit (54) to move out of alignment with the longitudinal axis (A) in response to misalignment between the first and second apertures (50, 52). In addition, the rigid conduit (54) provides resistance to torque imposed upon the coupling mechanism (30).

Lens finishing apparatus

Process For Producing Glycolic Acid From Formaldehyde and Hydrogen Cyanide

A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived from Acidovorax facilis 72W (ATCC 57746). Glycolic acid is recovered in the form of the acid or salt from the aqueous ammonium glycolate solution using a variety of methods described herein.

Variable displacement radial piston fluid working machine

1 Abstract (Figure 3) 3 A variable displacement fluid working machine for use in applications where a large 4 fluid working machine is required at an inaccessible location, for example, in the 5 nacelle of a wind turbine tower. 7 The machine includes an inward ring and an outward ring, one of the inward ring and 8 the outward ring comprising a rotatable ring cam coupled to a drive shaft, the other 9 comprising a plurality of radially extending piston cylinders circumferentially spaced 10 around the respective ring. The outward ring comprising first and second axially 11 spaced structural members and a plurality of demountable blocks demountably 12 retainable therebetween, the demountable blocks comprising either piston cylinders 13 or ring cam segments. 15 The demountable blocks are removable radially to facilitate maintenance and repair 16 and to facilitate radial access to the inward ring. Components of the inward ring may 17 also be removed radially through the resulting gap. The demountable blocks also 18 have a structural function, enabling the mass of the machine to be less than would 19 otherwise be required.

Electrical connector

Die Verbinderanordnung enthält einen sich entlang einer Länge erstreckenden Körper mit einer durch eine erste Fläche und eine gegenüberliegende zweite Fläche definierte Längshöhe. Mindestens ein Anschluss ragt durch den Körper. Der Anschluss enthält einen Flachstecker, der sich von der ersten Fläche zur elektrischen Verbindung mit einem Gegenverbinder erstreckt. Des Weiteren enthält der Anschluss ein Bein, das sich von der zweiten Fläche erstreckt. Eine Nase weist eine konvexe Fläche auf und ist an einem distalen Ende des Beins ohne dort hindurch ausgebildete Öffnungen ausgebildet. Die konvexe Fläche ist zur elektrischen Verbindung mit einer Montagefläche eines elektronischen Bauteils bei Empfang eines vorbestimmten Signals ausgeführt. The connector assembly includes a longitudinally extending body having a longitudinal height defined by a first surface and an opposing second surface. At least one connection protrudes through the body. The terminal includes a tab that extends from the first face for electrical connection to a mating connector. Furthermore, the port includes a leg extending from the second surface. A nose has a convex surface and is formed at a distal end of the leg without openings formed therethrough. The convex surface is designed to be electrically connected to a mounting surface of an electronic component upon receipt of a predetermined signal.

Hydraulic coupling having self-adjusting anti-rotation hydraulic fluid path.

Un acoplamiento hidráulico (10) para uso en un tren motriz de vehículo teniendo una trayectoria de fluidos (48) la cual se extiende entre el alojamiento (12) del acoplamiento hidráulico (10) y un mecanismo de acoplamiento (30). La trayectoria de fluidos (48) incluye una primera apertura (50) formada en el alojamiento (12) con un primer diámetro y un eje longitudinal (A), así como una segunda apertura (52) formada en el mecanismo de acoplamiento (30). Un conducto rígido (54) se extiende entre las primera y segunda aperturas (50, 52) con una primera porción teniendo un diámetro que es menor que el primer diámetro de la primera apertura (50) tal que defina un espacio de ajuste (G) que permite que el conducto rígido (54) se mueva fuera de alineación con el eje longitudinal (A) en respuesta a mala alineación entre las primera y segunda aperturas (50, 52). Además, el conducto rígido (54) proporciona resistencia a par de torsión impuesto sobre el mecanismo de acoplamiento (50).

Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor

A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Machine for modling candy pipes and other articles.

Methods for determining the genetic affinity of microorganisms and viruses

Selecting which sub-sequences in a database of nucleic acid such as 16S rRNA are highly characteristic of particular groupings of bacteria, microorganisms, fungi, etc. on a substantially phylogenectic tree. Also applicable to viruses comprising viral genomic RNA or DNA. A catalogue of highly characteristic sequences identified by this method is assembled to establish the genetic identity of an unknown organism. The characteristic sequences are used to design nucleic acid hybridization probes that include the characteristic sequence or its complement, or are derived from one or more characteristic sequences. A plurality of these characteristic sequences is used in hybridization to determine the phylogenetic tree position of the organism(s) in a sample. Those target organisms represented in the original sequence database and sufficient characteristic sequences can identify to the species or subspecies level. Oligonucleotide arrays of many probes are especially preferred. A hybridization signal can comprise fluorescence, chemiluminescence, or isotopic labeling, etc.; or sequences in a sample can be detected by direct means, e.g. mass spectrometry. The method's characteristic sequences can also be used to design specific PCR primers. The method uniquely identifies the phylogenetic affinity of an unknown organism without requiring prior knowledge of what is present in the sample. Even if the organism has not been previously encountered, the method still provides useful information about which phylogenetic tree bifurcation nodes encompass the organism.

Closure device for egg crates

Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor

A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Gate.

Verfahren und Vorrichtung zum Poekeln von Fleischprodukten

Groin protector

A groin protector, more specifically a groin protector for protecting the groin during physical activity is described. The groin protector comprises a cup portion, and at least one flange, wherein said flange is curved and extends from the cup, characterised in that the flange is suitable to rest against the body of the user, locating the groin protector in place relative to the anatomy of the user.

Manufacture of built-up heels

Chain grate

Procedimento e dispositivo per misurare la concentrazione di plutonio in flussi liquidi di processo

Improvements in Wheels for Railway and Tramway Vehicles.

12,067. Thorpe, J., and Fox, G. June 13. Wheels.-The tyre a is secured to the wheel without the use of bolts, rings, rivets, or screws Near the back of the tyre is formed a shallow groove b, having a thin lip c of which alternate portions d are cut away. The wheel f is cast with projections g in line with the spokes, these projections being slightly shorter than the recesses d and projections e on the tyre. The wheel is then fitted to the tyre so that the projections g come under the projections e, the corners of which are pressed or hammered down at h so as to prevent the wheel from moving in the tyre.

Car-coupling.

ガスバリア性包装用板紙

【課題】カートンやカップに成形されうる包装用板紙であって、カートンの耐久性やピンホールの問題が無く、板紙への材料の接着性が良好なガスバリア性を備える包装用板紙を提供する。 【解決手段】脂肪族ナイロン、芳香族ナイロン、またはナイロンのブレンドとポリエチレンテレフタレートとのブレンドを含んでなるガスバリア層１４；結合層１６；低密度ポリエチレン層；の３層をピンホールをシールし、押し出しまたは共押し出しラミネーションより迅速で低コストな方法による板紙１２構造体。 【選択図】図１

Campbell etal carnival weight-lifting amusement device or the like

Cooker.

Shingle sawing machine

Impressora que permite a retirada de documentos a vontade

Closure device for egg crates

Sash window assemblies

Chain-grate stoker

Latch for the closing of end-gates.

An Improvement in the Construction of Indexes.

18,660. Nunn, H., and Fox, A. G. Aug. 12. Indexing.-A transparent lamina of an artificial substance such as celluloid or xylonite is applied to the index of a ledger, letter file, or other index.

Furnace for steam generators

Means for feeding fuel furnaces

Improvements in or relating to mixers

Watch casing and bezel

Design fora broom-holder

uso de ácidos de lúpulo para controle de contaminação bacteriana em fermentações com o uso de zymomonas mobilis.

Trap work for pianos.

Recombinant fungal strains and methods thereof for producing consistent proteins

Certain one or more embodiments of the instant disclosure are related to, inter alia , recombinant (genetically modified) filamentous fungal cells (strains) producing proteins of interest, methods and compositions for the design and construction of modified filamentous fungal cells producing proteins of interest, methods and compositions for the expression/production/secretion/recovery and the like of endogenous and/or heterologous proteins of interest ( e.g ., phytases, lipases, glucoamylases, phospholipases, esterases, cellulases, hemicellulases, xylanases, etc .) in modified filamentous fungal cells, methods and compositions for producing proteins of interest in recombinant filamentous fungal, wherein the proteins produced and secreted into the broth and/or proteins recovered from the broth have uniform and consistent N-linked glycosylation patterns, and/or reduced (unwanted) glycation of one or more proteins of interest, and the like.

Design for a rug

Cultivator.

[UNK]

Desk pad

Gas mixer

Improvements in or relating to electrical apparatus for use in applying tips to machine and other tools

Improvements in or relating to electrical apparatus for use in applying tips to machine and other tools