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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 7. Отображено 7.
23-10-2013 дата публикации

Method for refining Gefinitib crystal form I

Номер: CN103360326A
Автор: Liu Yongdong, Che Xiaoming, Min Tao, Gu Chuanhu, Chao Yang
Принадлежит:

The invention relates to a method for refining a Gefinitib crystal form I. The method comprises the steps of dissolving a Gefinitib crude product into a mixed solution formed by mixing C2-C5 alcohol with any of acetonitrile, acetone, DMF (Dimethyl Formamide), ethyl formate, methyl tert-butyl ether, methyl acetate, ethyl acetate, propyl acetate and isopropyl acetate according to the volume ratio of (10-1): (1-5), lowering the temperature of a reaction solution, then crystallizing, filtering and drying, thereby obtaining the refined Gefinitib crystal form I, wherein the mass/volume ratio of Gefinitib to the mixed solution is 1: (5-30). The Gefinitib crystal form I prepared by the method has the advantages that the yield is high, the chromatographic purity is basically over 99.5%, and the maximum individual impurity is lower than 0.1%; and the method is simple in preparation and stable in process and is very suitable for large-scale production.

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Номер записи: 1
10-10-2012 дата публикации

Cloning, expressing and protein-purifying method for OPN gene

Номер: CN102719470A
Автор: Chen Aiping, Gu Chuanhu, Jiang Sheng, Liang Jing, Zhang Feng
Принадлежит:

The invention provides a method for expressing OPN (osteopontin) through a prokaryotic expression system. The method comprises the following steps of: firstly, establishing a cloning vector TA-OPN of the OPN and an expression vector pET-28a (+)-OPN; and performing prokaryotic expression, separation and purification on the OPN. The prepared osteopontin has the advantages of high yield, high purity and low cost. The invention also provides application of the osteopontin prepared by a cloning, expressing and protein-purifying method for an OPN gene to preparation of medicines for preventing or treating colorectal cancer, pancreatic cancer, ovarian cancer, lung cancer and liver cancer.

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Номер записи: 2
04-07-2012 дата публикации

Pharmaceutical composition for treating cerebrovascular diseases

Номер: CN102526035A
Автор: Jiang Shuishi, Bao Yusheng, Chen Min, Chao Yang, Ye Hai, Gu Chuanhu, Li Zhenghai, Yao Luoyuan
Принадлежит:

The invention relates to a pharmaceutical composition for treating cerebrovascular diseases, especially ischemic cerebrovascular diseases, which comprises 3-methyl-1-phenyl-2-pyrazoline-5-one, 2-taurine and a pharmaceutically-acceptable adjuvant or carrier. 3-methyl-1-phenyl-2-pyrazoline-5-one and 2-taurine in the pharmaceutical composition have a synergistic action, and can enhance drug effect and reduce toxic and adverse effects. The composition of the invention is suitable for clinical administration.

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Номер записи: 3
08-05-2013 дата публикации

Salts of sitafloxacin and pharmaceutical purposes thereof

Номер: CN103087042A
Автор: Chao Yang, Ye Hai, Che Xiaoming, Gu Chuanhu, Bao Yusheng
Принадлежит:

The invention provides acid addition salts of sitafloxacin represented by the formula, crystal forms and preparation methods of the salts, and pharmaceutical compositions, preparations and pharmaceutical purposes of the salts, wherein A is described in the specification. Both stability and water-solubility of the salts of the sitafloxacin or the crystal forms are better than that of sitafloxacin free alkali; furthermore, the irritation is less than that of the sitafloxacin free alkali; and the compositions or preparations prepared from the salts are applied to clinical applications.

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Номер записи: 4
12-09-2012 дата публикации

Method for synthesizing and purifying dexlansoprazole

Номер: CN102659763A
Автор: Min Tao, Che Xiaoming, Chao Yang, Ye Hai, Gu Chuanhu, Hu Yuqin
Принадлежит:

The invention mainly relates to an improved method for synthesizing dexlansoprazole by utilizing a Sharpless asymmetric oxidation method and an optimized method for purifying dexlansoprazole. According to the method, the total yield is above 40% and the purity of the product and the enantiomeric excess (e.e.) are both above 99.5%. The preparation method is simple, is low in cost and is suitable for industrial production.

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Номер записи: 5
30-01-2013 дата публикации

Preparation method of esomeprazole magnesium

Номер: CN102898418A
Автор: Min Tao, Xu Xiaoxia, Liu Chunmeng, Gu Chuanhu
Принадлежит:

The invention relates to a preparation method of esomeprazole magnesium. The method comprises the steps that: esomeprazole is dissolved in an organic solvent; a potassium-containing alkali or salt is subjected to a reaction with esomeprazole, such that esomeprazole potassium is produced; and esomeprazole potassium is subjected to a displacement reaction with a magnesium salt, such that esomeprazole magnesium is prepared. The invention also relates to a refining method of esomeprazole magnesium. With the method provided by the invention, the purity of the prepared esomeprazole magnesium is higher than 99.9%, the yield is higher than 82%, and esomeprazole magnesium has good morphological stability. With the method, requirements by factory pharmacy for purity and yield can be satisfied.

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Номер записи: 6
10-10-2012 дата публикации

Application of oligopeptide to preparation of medicine for treating angiogenesis ophthalmic diseases

Номер: CN102716464A
Автор: Chen Huimin, Xu Nianqin, Liu Tao, Gu Chuanhu, Gong Hui
Принадлежит:

The invention relates to an application of oligopeptide FpAT or pharmacy acceptable salt with the amino acid sequences shown by Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg to the preparation of medicine for preventing and/or treating ophthalmic diseases relevant to angiogenesis. The medicine prepared from the oligopeptide FpAT has the advantages of good curative effect and high safety on ophthalmic diseases relevant to angiogenesis, particularly on diseases relevant to CNV (choroidal neovascularization). In addition, because the chemical ingredients are polypeptide, the preparation technology is mature, the medication cost is low, and the oligopeptide is very suitable for clinic use or popularization.

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Номер записи: 7