05-12-2019 дата публикации
Номер: US20190367465A1
Принадлежит:
A heterocyclic urea compound, and specifically discloses an indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound, which solves the problems of weak curative effect and larger toxic and side effects of existing immunological therapy drugs. The invention further provides a preparation method for an indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound, and an application of the indoleamine-2,3-dioxygenase inhibitor of a heterocyclic urea compound or a pharmaceutically acceptable salt thereof in preparing drugs for treating or preventing tumors. 2. The heterocyclic urea compound claim 1 , or the pharmaceutically acceptable salt claim 1 , the isomer claim 1 , the racemate claim 1 , the prodrug or the solvate thereof according to claim 1 , wherein the C-Caryl claim 1 , the heteroaryl claim 1 , the —CH—(C-Caryl) and the —CH-heteroaryl contain or do not contain one or more substituents claim 1 , and the substituent is selected from the halogen claim 1 , the amino claim 1 , the hydroxyl claim 1 , the nitro claim 1 , the cyano claim 1 , the C-Calkyl claim 1 , the C-Calkoxy claim 1 , a C-Caminoalkyl claim 1 , the C-Cacyl claim 1 , the C-Cacyloxy claim 1 , a C-Cthioalkyl claim 1 , the carboxyl or a phenyl; and{'sub': 3', '12', '1', '12', '1', '12', '1', '12', '1', '12', '1', '12', '1', '12, 'the C-Ccycloalkyl contains or does not contain one or more substituents, and the substituent is selected from the halogen, the amino, the hydroxyl, the nitro, the cyano, the C-Calkyl, the C-Calkoxy, the C-Caminoalkyl, a C-Cacyl, a C-Cacyloxy, a C-Csulfonylalkyl, the carboxyl or the phenyl.'}4. The heterocyclic urea compound claim 3 , or the pharmaceutically acceptable salt claim 3 , the isomer claim 3 , the racemate claim 3 , the prodrug or the solvate thereof according to claim 3 , wherein the organic solvent is selected from one or more of a dichloromethane claim 3 , a tetrahydrofuran claim 3 , a dimethylformamide claim 3 , an ethylene glycol dimethyl ...
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