09-05-2013 дата публикации
Номер: US20130116145A1
Принадлежит:
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein. 160-. (canceled)61. A positionally-addressable array of polynucleotides bound to a support comprising: at least five (5) different means for distinguishing a breast cancer patient with a good prognosis from a breast cancer patient with a poor prognosis.62. The positionally-addressable array of claim 61 , wherein each of the five means for distinguishing a breast cancer patient with a good prognosis from a breast cancer patient with a poor prognosis is a nucleic acid molecule selected from the group consisting of SEQ ID NO:1 claim 61 , SEQ ID NO:37 claim 61 , SEQ ID NO:55 claim 61 , SEQ ID NO:58 claim 61 , SEQ ID NO:62; SEQ ID NO:75 claim 61 , SEQ ID NO:88 claim 61 , SEQ ID NO:120 claim 61 , SEQ ID NO 121 claim 61 , SEQ ID NO:124 claim 61 , SEQ ID NO:137 claim 61 , SEQ ID NO:169 claim 61 , SEQ ID NO:173 claim 61 , SEQ ID NO: 177 claim 61 , SEQ ID NO:183 claim 61 , SEQ ID NO:189 claim 61 , SEQ ID NO: 196 claim 61 , SEQ ID NO:219 claim 61 , SEQ ID NO:257 claim 61 , SEQ ID NO:259 claim 61 , SEQ ID NO:270 claim 61 , SEQ ID NO:271 claim 61 , SEQ ID NO:272 claim 61 , SEQ ID NO:306 claim 61 , SEQ ID NO:307 claim 61 , SEQ ID NO:315 claim 61 , SEQ ID NO:326 claim 61 , SEQ ID NO:327 claim 61 , SEQ ID NO:336 claim 61 , SEQ ID NO:353S SEQ ID NO:357 claim 61 , SEQ ID NO:390 claim ...
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