09-08-2018 дата публикации
Номер: US20180223102A1
Принадлежит:
Compounds of formula I are disclosed: 2. The compound according to claim 1 , wherein the amine is a member selected from the group consisting of NH claim 1 , NH(alkyl) claim 1 , NH(aryl) claim 1 , N(alkyl)(aryl) and N(alkyl).3. The compound according to claim 1 , where Z and X claim 1 , taken with the atoms to which they are bonded claim 1 , form a substituted or unsubstituted 5-7 membered ring claim 1 , substituted with at least one additional heteroatom selected from the group consisting of N claim 1 , O and S and/or at least one substituent selected from the group consisting of F claim 1 , Cl claim 1 , Br claim 1 , I claim 1 , CN claim 1 , N claim 1 , B(OR)(OR) claim 1 , OR claim 1 , SR claim 1 , NRR claim 1 , COR claim 1 , COOR claim 1 , CONRR claim 1 , PORR claim 1 , SOR claim 1 , SORand R claim 1 , where R claim 1 , R claim 1 , Rare defined as in .5. The compound according to claim 1 , wherein Rof COORis N-succinimidyl claim 1 , N-phthalimidyl claim 1 , N-tetrachlorphthalimidyl claim 1 , pentachlorophenyl claim 1 , pentafluorophenyl claim 1 , 2 claim 1 ,3 claim 1 ,5 claim 1 ,6-tetrafluorophenyl claim 1 , 4-(hydroxysulfonyl)-2 claim 1 ,3 claim 1 ,5 claim 1 ,6-tetrafluorophenyl [p-(HOSO)CF] claim 1 , 1-benzotriazolyl or cyanomethyl.6. The compound according to claim 1 , wherein ORis OCOOR claim 1 , where Ris N-succinimidyl claim 1 , N-phthalimidyl claim 1 , N-tetrachlorophthalimidyl claim 1 , pentachlorophenyl claim 1 , pentafluorophenyl claim 1 , 2 claim 1 ,3 claim 1 ,5 claim 1 ,6-tetrafluorophenyl claim 1 , 4-(hydroxysulfonyl)-2 claim 1 ,3 claim 1 ,5 claim 1 ,6-tetrafluorophenyl [p-(HOSO)CF] claim 1 , 1-benzotriazolyl or cyanomethyl.9. The compound according to in a form of a salt with organic or inorganic counterion(s) claim 1 , its cocrystal with another organic or inorganic compound(s) claim 1 , or a composition containing any of the dyes of .10. A conjugate or bioconjugate comprising a compound according to coupled via at least one covalent chemical bond ...
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