03-01-2013 дата публикации
Номер: US20130005738A1
Автор:
Dalgarno David C.,
Huang Wei-Sheng,
III Chester A.,
Metcalf,
Qi Jiwei,
Romero Jan Antoinette C.,
Sawyer Tomi K.,
Shakespeare William C.,
Sundaramoorthi Rajeswari,
Thomas R. Mathew,
Wang Yihan,
Zhu Xiaotian,
Zou Dong
This invention relates to compounds of the general formula: 4. A compound according to claim 3 , wherein Rings A and B are aryl.5. A compound of wherein Ring C is a heteroaryl ring.6. A compound of wherein Ring C is an imidazole ring.8. A compound of wherein Ris independently selected from —CH claim 7 , or —C(O)NH claim 7 , v is 1 claim 7 , n is 0 or 1 claim 7 , m is 1 claim 7 , t is 1 claim 7 , Ris —CH claim 7 , Ris CFand Ris —CH.10. A compound according to wherein Rings A and B are aryl.11. A compound of wherein Ring D is a substituted or unsubstituted piperazine ring and Lis CH.12. A compound of wherein Ring D is a substituted or unsubstituted heteroaryl.14. A compound of wherein Ris independently selected from —CHand —C(O)NH claim 13 , n is 0 or 1 claim 13 , m is 1 claim 13 , t is 1 claim 13 , Ris methyl claim 13 , Ris CF claim 13 , one of Ris selected from methyl and CHCHOH.1514. A method for treating cancer in a mammal in need thereof claims 1 , comprising administering to the mammal a therapeutically effective amount of a compound of any of - or a pharmaceutically acceptable salt claims 1 , solvate or hydrate thereof.1614. A composition comprising a compound of any of - or a pharmaceutically acceptable salt claims 1 , solvate or hydrate thereof and a pharmaceutically acceptable carrier claims 1 , diluent or vehicle. The protein kinases represent a large family of proteins, which play a central role in the regulation of a wide variety of cellular processes and maintaining control over cellular function. A partial, non limiting, list of such kinases includes abl, Akt, bcr-abl, Blk, Brk, c-kit, c-met, c-src, CDK1, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, cRaf1, CSK, EGFR, ErbB2, ErbB3, ErbB4, Erk, Pak, fes, FGFR1, FGFR2, FGFR3, FGFR4, FGFR5, Fgr, flt-1, Fps, Frk, Fyn, Hck, IGF-1R, INS-R, Jak, KDR, Lck, Lyn, MEK, p38, PDGFR, PIK, PKC, PYK2, ros, tie, tie2, TRK and Zap70. Abnormal protein kinase activity has been related to several disorders, ranging ...
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