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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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26-01-2012 дата публикации

PORTABLE COMPUTER DISPLAY STRUCTURES

Номер: US20120020000A1
Автор: Augenbergs Peteris K., Degner Brett W., JR. Thomas W., Ligtenberg Chris, Mathew Dinesh C., Posner Bryan W., Wilson, Yin Victor H.
Принадлежит:

An electronic device housing may have upper and lower portions that are attached with a hinge. At least one portion of the housing may have a rear planar surface and peripheral sidewalls having edges. A display module may be mounted in the housing. The display module may have glass layers such as a color filter glass layer and a thin-film transistor substrate. The color filter glass layer may serve as the outermost glass layer in the display module. The edges of the display module may be aligned with the edges of the peripheral housing sidewalls to create the appearance of a borderless display for the electronic device. The display module may be provided with an opening that allows a camera or other electronic components to receive light. Traces may be provided on the underside of the thin-film transistor substrate to serve as signal paths for the electrical components. 1. A portable computer , comprising:upper and lower housings coupled by a hinge;a display in the upper housing that includes a rectangular color filter layer, a rectangular thin-film transistor layer, and at least one polarizer layer, wherein the color filter layer has a rectangular periphery with a peripheral edge; anda structure located along the peripheral edge of the color filter layer and at least partially surrounding the periphery of the color filter layer, wherein the upper housing has an inner edge surface that runs parallel to at least some of the peripheral edge of the color filter layer and wherein the structure is interposed between at least some of the inner edge surface of the upper housing and the peripheral edge of the color filter layer and provides an interface between the color filter layer and the upper housing.2. The portable computer defined in wherein the structure comprises an elastomeric structure.3. The portable computer defined in wherein the structure comprises a gasket.4. The portable computer defined in wherein the upper housing comprises metal and wherein the structure ...

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Номер записи: 1
26-01-2012 дата публикации

Portable computer display structures

Номер: US20120020002A1
Автор: Brett W. Degner, Bryan W. Posner, Chris Ligtenberg, Dinesh C. Mathew, Peteris K. Augenbergs, Thomas W. Wilson, JR., Victor H. Yin
Принадлежит: Individual

An electronic device housing may have upper and lower portions that are attached with a hinge. At least one portion of the housing may have a rear planar surface and peripheral sidewalls having edges. A display module may be mounted in the housing. The display module may have glass layers such as a color filter glass layer and a thin-film transistor substrate. The color filter glass layer may serve as the outermost glass layer in the display module. The edges of the display module may be aligned with the edges of the peripheral housing sidewalls to create the appearance of a borderless display for the electronic device. The display module may be provided with an opening that allows a camera or other electronic components to receive light. Traces may be provided on the underside of the thin-film transistor substrate to serve as signal paths for the electrical components.

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Номер записи: 2
16-02-2012 дата публикации

Lentiviral Vectors Pseudotyped with a Sindbis Virus Envelope Glycoprotein

Номер: US20120039932A1
Автор: Allen James M., Dubensky, JR. Thomas W., Li Jin Zhong, Sloan Derek D., Van Hoeven Neal S.
Принадлежит: IMMUNE DESIGN CORP.

Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle comprising: (a) an envelope comprising a Sindbis virus E2 glycoprotein variant; and (b) a lentiviral vector genome comprising a sequence of interest; wherein the E2 glycoprotein variant facilitates infection of dendritic cells by the lentiviral vector particle, and wherein the E2 glycoprotein variant has reduced binding to heparan sulfate compared to a reference sequence (HR strain). 127-. (canceled)28. A lentiviral vector particle capable of infecting dendritic cells comprising:(a) an envelope comprising a variant of Sindbis virus E2 glycoprotein (SEQ ID NO: 1) having at least 80% identity to the amino acid sequence of SEQ ID NO: 1 and in which (i) residue 160 is absent or is an amino acid other than glutamic acid, (ii) the E2 glycoprotein variant is not part of a fusion protein with Sindbis virus E3 glycoprotein; and (iii) the sequence of residues 71-75 of SEQ ID NO:1 is unchanged or has one or two substitutions which do not affect the ability of the variant to infect DCs, and(b) a lentiviral vector genome comprising a nucleotide sequence encoding an antigen.29. The lentiviral vector particle of claim 28 , wherein the E2 glycoprotein variant binds to DC-SIGN.30. The lentiviral vector particle of claim 28 , wherein residue 160 is absent or is glycine claim 28 , alanine claim 28 , valine claim 28 , leucine or isoleucine.31. The lentiviral vector particle of claim 28 , wherein residue 160 is glycine.32. The lentiviral vector particle of claim 28 , wherein the E2 glycoprotein variant has at least one amino acid altered to reduce its net positive charge.33. The lentiviral vector particle of claim 32 , wherein the altered amino acid is selected from the group consisting of lysine 70 claim 32 , lysine 76 claim 32 , or lysine 159 of SEQ ID NO:1 claim 32 , and is altered by substitution ...

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Номер записи: 3
01-03-2012 дата публикации

ELECTRONIC DEVICE DISPLAY MODULE

Номер: US20120050975A1
Автор: Augenbergs Peteris K., Damianakis Michael A., Degner Brett W., Garelli Adam T., Hamel Bradley J., Hendren Keith J., JR. Thomas W., KESSLER Patrick, Mathew Dinesh C., Wilson
Принадлежит:

Electronic devices may have housings. A housing may contain a display on its front face and a rear plate such as a plate formed from glass on its rear face. A peripheral housing member may surround the display and rear plate. An antenna may be formed in the peripheral housing member. The rear plate may be formed from laminated layers including a light guide layer. Device hinges may include hinge structures that are integral to the peripheral housing member. A logo may be formed by coating the rear plate with a patterned masking layer. Display structures for the display and the rear plate may be mounted to opposing sides of a shelf portion of the peripheral housing member. The rear plate may be formed from electrochromic glass and may cover photovoltaic cells and touch sensors. Driver boards may be mounted within a clutch barrel perpendicular to the display. 1. A portable computer , comprising:upper and lower housings, wherein the upper housing has a front side and a rear side;a hinge connecting the upper and lower housings;a display mounted in the front side of the upper housing, wherein the display has four edges;a peripheral housing member that surrounds the four edges of the display; anda rectangular plate that is mounted within the peripheral housing member on the rear side of the upper housing.2. The portable computer defined in wherein the peripheral housing member comprises metal.3. The portable computer defined in wherein the rectangular plate comprises a material selected from the group consisting of: metal claim 2 , glass claim 2 , ceramic claim 2 , fiber composite claim 2 , and plastic.4. The portable computer defined in wherein the rectangular plate comprises glass.5. The portable computer defined in wherein the peripheral housing member comprises fiber composite material.6. The portable computer defined in wherein the peripheral housing member comprises an opening in which an antenna is formed.7. The portable computer defined in wherein the peripheral ...

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Номер записи: 4
26-04-2012 дата публикации

COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEPATITIS C

Номер: US20120100170A1
Автор: Dubensky, JR. Thomas W., Lauer Peter M.
Принадлежит:

The present invention provides compositions and methods for delivery of one or more hepatitis C virus (HCV) antigens using a bacterium recombinantly encoding and expressing such antigens. In certain embodiments, the bacterial platform comprises the use of attenuated and killed but metabolically active forms of 193-. (canceled)94. A method of inducing a T-cell response to hepatitis C virus (HCV) in a subject , said method comprising:administering to said subject a composition comprising a bacterium which expresses one or more immunogenic HCV antigen polypeptides, the amino acid sequence of which comprise(i) one or more full length HCV proteins selected from the group consisting of core, E1, E2, p7, NS2, NS3, NS4a, NS4b, NS5a, and NS5b;(ii) one or more immunogenic amino acid sequences derived from one or more full length HCV proteins from (i); ora combination of one or more full length HCV proteins of (i) and one or more amino acid sequences of (ii);under conditions selected to induce said T cell response in said subject.95. The method of wherein said immunogenic HCV antigen polypeptide(s) comprise one or more amino acid sequences selected from the group consisting of full length NS3 claim 94 , full length NS5b claim 94 , an amino acid sequence derived from NS3 claim 94 , and an amino acid sequence derived from NS5b.96. The method of wherein said immunogenic HCV antigen polypeptide(s) comprise one or more amino acid sequences selected from the group consisting of an amino acid sequence comprising at least 100 contiguous residues from NS3 claim 94 , and an amino acid sequence comprising at least 100 contiguous residues from NS5b.97. The method of wherein said immunogenic HCV antigen polypeptide(s) comprise one or more amino acid sequences selected from the group consisting of an amino acid sequence having at least 90% sequence identity to at least 100 contiguous residues from NS3 claim 94 , and an amino acid sequence having at least 90% sequence identity to at least ...

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Номер записи: 5
03-05-2012 дата публикации

CAMERA LENS STRUCTURES AND DISPLAY STRUCTURES FOR ELECTRONIC DEVICES

Номер: US20120105400A1
Автор: Garelli Adam T., Hendren Keith J., JR. Thomas W., Mathew Dinesh C., Wilson
Принадлежит:

A camera may be mounted under a display in an electronic device. The display may include a polarizer layer, a color filter layer, and a thin-film-transistor layer. A layer of material such as a glass insert may be attached to an edge of the display. Openings may be formed in the layers of the display and the insert to accommodate the camera. A sleeve structure may be mounted within an opening. The camera may include lens structures formed from a stack of lens elements. One or more layers of the display may be interposed within the lens structures. The glass insert may be mounted within a notch in the color filter layer and thin-film transistor layer or along a straight edge of the color filter layer and thin-film transistor layer. The edge of the color filter layer may be recessed with respect to form a mounting shelf for the insert. 1. An electronic device , comprising:a display having layers; anda camera including lens structures and an image sensor that receives image light through the lens structures, wherein the lens structures comprise a first portion and a second portion and wherein at least one of the layers of the display is interposed between the first and second portions of the lens structures.2. The electronic device defined in wherein the first portion comprises a plurality of lens elements.3. The electronic device defined in wherein the second portion comprises a plurality of lens elements.4. The electronic device defined in wherein the at least one layer comprises a color filter layer.5. The electronic device defined in wherein the at least one layer comprises a thin-film transistor layer.6. The electronic device defined in wherein the at least one layer comprises a color filter layer and a thin-film transistor layer.7. The electronic device defined in wherein the at least one layer comprises a color filter layer.8. The electronic device defined in wherein the at least one layer comprises a color filter layer and a thin-film transistor layer.9. The ...

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Номер записи: 6
10-05-2012 дата публикации

NUCLEIC ACID MUCOSAL IMMUNIZATION

Номер: US20120114693A1
Автор: "OHagan Derek", Dubensky, JR. Thomas W., Polo John, Vajdy Michael
Принадлежит: Novartis Vaccines and Diagnostics, Inc.

Mucosal delivery of antigens using, for example, a replication-defective gene delivery vehicle, particularly replication-defective alphavirus vectors and particles, is described. Also described are compositions comprising a mucosal adjuvant and one or more antigens derived from HIV. Also provided is the use of these gene delivery vehicles in inducing mucosal, local, and/or systemic immune responses following mucosal immunization regimes. 1. A method of generating an immune response in a subject comprising(a) administering to the subject a first replication-defective gene delivery vehicle wherein the replication-defective gene delivery vehicle encodes a first antigenwherein the first replication-defective gene delivery vehicle is administered mucosally, and(b) administering to the subject a second replication-defective gene delivery vehicle wherein the replication-defective gene delivery vehicle encodes a second antigen.2. The method of wherein the mucosal administration is intranasal.3. The method of wherein the mucosal administration is intrarectal.4. The method of wherein the mucosal administration is intravaginal.5. The method of wherein the second replication-defective gene delivery vehicle is administered mucosally.6. The method of wherein the mucosal administration is intranasal.7. The method of wherein the mucosal administration is intrarectal.8. The method of wherein the mucosal administration is intravaginal.9. The method of wherein the first replication-defective gene delivery vehicle is selected from the group consisting of a non-viral vector claim 1 , and alphavirus vector claim 1 , and an adenovirus vector.10. The method of wherein the second replication-defective gene delivery vehicle is selected from the group consisting of a non-viral vector claim 1 , and alphavirus vector claim 1 , and an adenovirus vector.11. The method of wherein the first replication-defective gene delivery vehicle is an alphavirus vector.12. The method of wherein the alphavirus ...

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Номер записи: 7
28-06-2012 дата публикации

Surgical Stapler

Номер: US20120160894A1
Автор: Dominick L. Mastri, Frank J. Viola, Jon Wilson, Robert J. Geiste, Thomas W. Alesi, Jr.
Принадлежит: TYCO HEALTHCARE GROUP LP

A surgical device is described herein that can be used to fire different types and sizes of disposable loading units. In a preferred embodiment, the device applies parallel rows of surgical fasteners to body tissue and concomitantly forms an incision between the rows of staples during an endoscopic or laparoscopic surgical procedure. The device can be utilized with disposable loading units configured to apply linear rows of staples measuring from about 15 mm in length to about 60 mm in length and can be used to fire disposable loading units containing surgical clips and individual staples.

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Номер записи: 8
19-07-2012 дата публикации

DISPLAY BACKLIGHT HAVING LIGHT GUIDE PLATE WITH LIGHT SOURCE HOLES AND DUAL SOURCE PACKAGES

Номер: US20120182497A1
Автор: Augenbergs Peteris K., DEFOREST Laura M., Garelli Adam T., Hendren Keith J., JR. Thomas W., Mathew Dinesh C., Posner Bryan W., Qi Jun, Wilson, Yin Victor H.
Принадлежит:

A display may include a backlight structure. The backlight structure may include a light guide plate. Holes in the light guide plate may be configured to receive corresponding light-emitting diodes. The holes may separate an edge portion of the light guide plate from a main central portion of the light guide plate. Adhesive may be attached to the lower surface of the edge portion. The adhesive may be attached to a device housing or may be attached to a flex circuit that is attached to the housing with additional adhesive. The light-emitting diodes may be mounted within packages in pairs. The packages may be mounted on the flex circuit. Traces on part of the flex circuit may be covered by part of the light guide plate without any intervening adhesive. A reflective structure may be interposed between the traces and parts of the main portion of the light guide plate. 1. A display , comprising:display structures;a light guide plate having a plurality of holes each of which is surrounded by portions of the light guide plate; andlight-emitting diodes mounted within the holes, wherein the light-emitting diodes emit backlight for the display structures into the light guide plate.2. The display defined in wherein the display structures include a thin-film transistor layer and a color filter layer.3. The display defined in wherein the holes comprise holes arranged in a row parallel to an edge of the light guide plate.4. The display defined in wherein the light-emitting diodes are mounted in pairs within packages.5. The display defined in wherein the packages each have a pair of terminals claim 4 , wherein two light-emitting diodes are connected in series between the pair of terminals in each package claim 4 , and wherein the terminals are connected to a substrate.6. The display defined in wherein the substrate comprises a flex circuit.7. The display defined in further comprising a reflector adjacent to the light guide plate claim 6 , wherein an edge of the reflector is ...

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Номер записи: 9
02-08-2012 дата публикации

Liquid Cooling System for Stackable Modules in Energy-Efficient Computing Systems

Номер: US20120194996A1
Автор: El-Essawy Wael R., JR. Thomas W., Keller, Roy Jarrod A., Rubio Juan C.
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

A computing system is provided. In the computing system, a plurality of modules physically arranged in a three dimensional hexadron configuration. In the computing system, the at least one module is either a liquid-tight module filled with a non-conductive liquid coolant or a module cooled with a liquid coolant circulating through cold plates mounted on electronic components. In the computing system, the liquid coolant is circulated in a closed loop by at least one pump through a plurality of hoses through at least one of a plurality of heat exchangers. In the computing system, the plurality of heat exchangers is coupled to an exterior portion of the surface of the computing system. In the computing system, the plurality of heat exchangers cool the liquid coolant through tinned tubes exposed to the surrounding air. 115-. (canceled)16. A liquid-tight module , comprising:a processing module top;a processing module bottom;a set of processing module sides, wherein each processing module side comprises:a circuit board;a plurality of connectors coupled to the circuit board; anda plurality of processing nodes coupled to the circuit board, wherein each processing module side in the set of processing module sides couples to another processing module side using at least one connector in the plurality of connectors such that when all of the set of processing module sides are coupled together with the processing module top and the processing module bottom, the liquid-tight module is formed, and wherein the liquid-tight module is filled with a non-conductive liquid coolant used to cool the plurality of processing nodes within the liquid-tight module, wherein the non-conductive liquid coolant is circulated in a closed loop by at least one pump through a plurality of tubes and at least one heat exchanger in a plurality of heat exchangers, wherein the at least one heat exchanger is coupled to an exterior portion of the liquid-tight module, and wherein the at least one heat ...

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Номер записи: 10
09-08-2012 дата публикации

WIRE MANAGEMENT METHOD WITH CURRENT AND VOLTAGE SENSING

Номер: US20120200285A1
Автор: CARPENTER GARY D., El-Essawy Wael, JR. Thomas W., Keller, Rubio Juan C.
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

A wire management method using a wire manager including current sensing features provides input for power measurement and management systems. The wire manager may be a single wire or single bundle retaining device with a current sensor such as a hall effect sensor integrated therein, or may be a multi-wire management housing with multiple current sensing devices disposed inside for measuring the current through multiple wires. The wires may be multiple branch circuits in a power distribution panel or raceway, and the wire manager may be adapted for mounting in such a panel or raceway. Voltage sensing may also be incorporated within the sensors by providing an electrically conductive plate, wire or other element that capacitively couples to the corresponding wire. 1. A method of providing energy usage measurement by a load , the method comprising:controlling a position of a wire delivering energy to the load with a wire managing device that secures the wire;measuring a current passing through the wire with a current sensor integrated within a body of the wire managing device; anddetermining an energy usage of the load from a result of the measuring.2. The method of claim 1 , further comprising sensing an electric potential at the wire using a voltage sensing element integrated in the wire managing device claim 1 , and wherein the determining further determines the energy usage in conformity with the result of the sensing of the electric potential.3. The method of claim 1 , wherein the controlling controls the position of multiple wires claim 1 , wherein the measuring measures corresponding currents passing through the multiple wires claim 1 , and wherein the determining determines an energy usage of multiple loads supplied by the multiple wires.4. The method of claim 3 , further comprising sensing electric potentials at one or more of the multiple wires using one or more voltage sensing elements integrated in the wire managing device claim 3 , and wherein the ...

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Номер записи: 11
30-08-2012 дата публикации

Spheroidal Aggregates of Mesenchymal Stem Cells

Номер: US20120219572A1
Автор: Bartosh, JR. Thomas W., Prockop Darwin J., Ylostalo Joni
Принадлежит:

The present invention encompasses methods and compositions for reducing inflammation in a mammal. The invention includes a population of mesenchimal stromal cells that possess anti-inflammatory, anti-apoptolic, immune modulatory, and anti-tumorigenic properties. 1. Mesenchymal stem cells in a spheroidal aggregate or mesenchymal stem cells obtained from a spheroidal aggregate , wherein said mesenchymal stem cells express increased amounts of at least one therapeutic protein compared to mesenchymal stem cells cultured as a monolayer.2. The cells of wherein said at least one therapeutic protein is selected from the group consisting of anti-inflammatory proteins claim 1 , anti-apoptotie proteins claim 1 , proteins that regulate cell growth and development claim 1 , proteins that regulate an immune response claim 1 , proteins that regulate hemotopoiesis claim 1 , proteins which inhibit claim 1 , prevent claim 1 , or destroy the growth of tumors claim 1 , proteins that regulate the homing of cells claim 1 , proteins that are involved in cell adhesion and cell signaling claim 1 , proteins that enhance angiogenesis claim 1 , and combinations thereof.3. The cells of wherein said therapeutic protein is an anti-inflammatory protein.4. The cells of wherein said anti-inflammatory protein is TSG-6.5. The cells of wherein said protein is an anti-apoptotie protein.6. The cells of wherein said anti-apoptotic protein is STC-1.7. The cells of wherein said protein is a protein that regulates cell growth and development.8. The cells of wherein said protein is LIF.9. The cells of wherein said protein is a protein that regulates hematopoiesis.10. The cells of wherein said protein is IL-11.11. The cells of wherein said protein inhibits claim 2 , prevents claim 2 , or destroys the growth or tumors.12. The cells of wherein said protein is TNF-α related apoptosis inducing ligand.13. The cells of wherein said protein is IL-24.14. The cells of wherein said protein is CD82.15. The cells of ...

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Номер записи: 12
06-09-2012 дата публикации

COMPACT FAN ASSEMBLY WITH THRUST BEARING

Номер: US20120224951A1
Автор: Degner Brett W., DUKE Connor R., Dybenko Jesse T., Hendren Keith J., JR. Thomas W., LIANG FRANK F., Phan Con D., Tan Cheng P., Wilson
Принадлежит: Apple Inc.

A fan assembly for a computing device is disclosed. The device can include an impeller having a number of blades and a motor for turning the blades. The motor can turn the blades via a magnetic interaction between the impeller and the motor. A thrust bearing can be used to control a position of the impeller relative to the motor. In particular, the impeller can be configured to rotate around an axis and the thrust bearing can be used to control movement of the impeller in a direction aligned with the axis. In one embodiment, the impeller can be configured to generate aerodynamic forces, such as lift, and the parameters associated with the thrust bearing can be selected to counteract the aerodynamic forces so that the impeller remains within a desired positional range relative to the motor. 1. A portable computing device comprising:a thin-profile enclosure; and 'a thin and compact fan assembly disposed with the thin-profile enclosure, the fan assembly including an impeller magnetically coupled to a motor configured to rotate the impeller, wherein the impeller includes a shaft with a thrust plate that allows the impeller to be coupled to a thrust bearing and wherein the thrust bearing is configured to control a position of the impeller relative to the motor such that the magnetic pre-load on the impeller is minimized to increase an efficiency at which rotational velocity is transferred from the motor to the impeller.', 'a thermal regulation system comprising2. The portable computing device of claim 1 , wherein the impeller includes a plurality of 3-D shaped blades wherein the blades are shaped to increase the aerodynamic performance of the fan.3. The portable computing device of claim 1 , wherein the impeller includes a plurality of 3-D shaped blades wherein the blades are shaped to reduce noise produced by the impeller blades.4. The portable computing device of claim 1 , wherein the thrust bearing is configured to control axial motions of the impeller relative to the ...

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Номер записи: 13
13-09-2012 дата публикации

Method for the Purification of Alphavirus Replicon Particles

Номер: US20120231526A1
Автор: Calderon-Cacia Maria, De La Vega, Dubensky, Greer Catherine, JR. Daniel, JR. Thomas W., Polo John M.
Принадлежит:

Methods of production and purification for viruses and virus-derived vectors, including those related to alphaviruses, are disclosed. In one aspect, methods of purification that subject alphavirus replicon particle preparations to one or more steps of chromatographic purification, such as using an ion exchange resin, are provided. Also disclosed are methods of characterizing alphavirus replicon particles and utilizing these materials for vaccines and gene-based therapeutics 1. A method for purifying alphavirus replicon particles comprising: a) contacting a preparation containing alphavirus replicon particles with a tentacle ion exchange resin , under conditions and for a time sufficient to bind to said resin; b) removing the portion of the preparation which is not bound to said ion exchange resin from said ion exchange resin; c) eluting the bound alphavirus replicon particles from said ion exchange resin; and d) recovering said replicon particles.2. The method according to wherein said tentacle ion exchange resin is a cationic exchange resin.3. The method according to wherein said tentacle ion exchange resin is an anionic exchange resin.4. A method for purifying alphavirus replicon particles comprising at least two chromatographic purification steps wherein said purification steps are selected from the group consisting of ion exchange chromatography claim 1 , size exclusion chromatography claim 1 , hydrophobic interaction chromatography claim 1 , affinity chromatography.5. The method according to wherein said ion exchange chromatography is performed using a tentacle ion exchange resin.6. The method according to wherein a first purification step is ion exchange chromatography and a second purification step is size exclusion chromatography. This application is a continuation of Ser. No. 12/212,978 filed on Sep. 18, 2008, which is a continuation of Ser. No. 10/881,575 filed Jun. 29, 2004, now abandoned, which is a division of Ser. No. 09/872,086 filed May 31, 2001, now ...

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Номер записи: 14
27-09-2012 дата публикации

Minimizing Aggregate Power from HVAC Cooling and IT Equipment in a Data Center

Номер: US20120245738A1
Автор: Allen-Ware Malcolm S., Carter John B., HAMANN HENDRIK F., Huang Wei, JR. Thomas W., Keller, Rubio Juan C.
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

A mechanism is provided for minimizing aggregate power from HVAC cooling and IT equipment in a data center. The mechanism selects a high HVAC set point for low-utilization and selects a low HVAC set point for high utilization. For each cooling zone in a data center, the mechanism monitors the average utilization of equipment in the cooling zone and selects the appropriate HVAC set point based on utilization. The mechanism may determine efficiency to determine whether to adjust universal HVAC set points or the HVAC set points for each given cooling zone. That is, the mechanism may dynamically adjust HVAC set points for optimal efficiency. Alternatively, the mechanism may go beyond binary control and compute actual data center efficiency metrics to decide on intermediate set points. 1. A method , in a data processing system , for minimizing aggregate power from cooling and equipment in a data center , the method comprising:monitoring average utilization level of equipment in a data center;setting heating, ventilation, and air conditioning (HVAC) set points based on utilization; andcooling the data center based on the HVAC set points.2. The method of claim 1 , wherein setting HVAC set points based on utilization comprises:for a given cooling zone, comparing utilization in the given cooling zone to a threshold;responsive to the comparison resulting in a determination that utilization of the given cooling zone is tow, setting an HVAC set point for the given cooling zone to a high temperature value; andresponsive to the comparison resulting in a determination that utilization of the given cooling zone is high, setting the HVAC set point of the given cooling zone to a low temperature value.3. The method of claim 2 , further comprising:collecting efficiency metrics for the given cooling zone;determining whether to change HVAC set points for the given cooling zone based on the efficiency metrics for the given cooling zone; andresponsive to a determination to change set ...

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Номер записи: 15
15-11-2012 дата публикации

SYNTHETIC LONG PEPTIDE (SLP)-BASED VACCINES

Номер: US20120288515A1
Автор: Dubensky, JR. Thomas W., Robbins Scott H.
Принадлежит: IMMUNE DESIGN CORP.

Synthetic long peptides and an adjuvant are formulated together and administered to a subject in order to raise an immune response. In certain embodiments, the adjuvant is GLA. 1. A immunogenic composition comprising one or more SLPs (synthetic long peptides) and an adjuvant , wherein the adjuvant comprises a disaccharide having a reducing and a non-reducing terminus each independently selected from glucosyl and amino substituted glucosyl , where a carbon at a 1 position of the non-reducing terminus is linked through either an ether (—O—) or amino (—NH—) group to a carbon at a 6′ position of the reducing terminus , the disaccharide being bonded to a phosphate group through a 4′ carbon of the non-reducing terminus and to a plurality of lipid groups through amide (—NH—C(O)—) and/or ester (—O—C(O)—) linkages , where the carbonyl (—C(O)—) group of the ester or amide linkage is directly linked to the lipid group , and each lipid group comprises at least 8 carbons.2. The composition of claim 1 , wherein the one or more SLPs are present at a concentration wherein an increase in the concentration results in a decrease in the immunogenicity of the composition.3. The composition of claim 1 , which comprises from about 0.1 μg to about 15 μg of each SLP.4. The composition of claim 1 , wherein the one or more SLPs are derived from an HSV-2 protein.5. The composition of claim 4 , wherein the HSV-2 protein is UL19.6. The composition of claim 1 , wherein the one or more SLPs are derived from a cancer antigen.7. The composition of claim 6 , wherein the cancer antigen is NY-ESO-1 claim 6 , TRP2 claim 6 , or CAIX.8. The composition of claim 1 , wherein the adjuvant is GLA.9. The composition of claim 1 , wherein the composition is aqueous and oil-free or comprises less than about 1% v/v oil.10. The composition of claim 1 , wherein the adjuvant is formulated in stable oil-in-water emulsion.11. A method of immunizing a subject against HSV-2 comprising administering an immunogenic ...

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Номер записи: 16
20-12-2012 дата публикации

Surgical Stapler

Номер: US20120318845A1
Автор: Alesi, Geiste Robert J., JR. Thomas W., Mastri Dominick L., Viola Frank J., Wilson Jon
Принадлежит: TYCO HEALTHCARE GROUP LP

A surgical device is described herein that can be used to fire different types and sizes of disposable loading units. In a preferred embodiment, the device applies parallel rows of surgical fasteners to body tissue and concomitantly forms an incision between the rows of staples during an endoscopic or laparoscopic surgical procedure. The device can be utilized with disposable loading units configured to apply linear rows of staples measuring from about 15 mm in length to about 60 mm in length and can be used to fire disposable loading units containing surgical clips and individual staples. 15-. (canceled)6. A surgical tool for applying staples , comprising:a body having a connection portion at one end and first and second jaws supported at the other end, the first jaw having a plurality of staples arranged in rows, and the second jaw having an anvil, the first and second jaws having an open position and a closed position; anda drive member supporting a cam member at a distal end, wherein the cam member is positioned to engage the second jaw, the drive member including an elongated drive beam, wherein the drive member includes a balancing flange positioned to engage the first jaw to balance clamping forces generated by the cam member as tissue is progressively clamped between the first and second jaws, the drive member having a proximal end disposed in the body so as to engage an actuation member when the surgical tool is connected to an actuator.7. The surgical tool according to claim 6 , wherein the first jaw includes a longitudinal slot for accommodating the drive member.8. The surgical device according to claim 6 , further comprising a handle assembly including a pivotable handle claim 6 , the handle assembly having the actuator.9. The surgical device according to claim 6 , wherein the first jaw includes a surgical stapling cartridge.10. The surgical device according to claim 6 , wherein the drive member includes a knife.11. The surgical device according to claim ...

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Номер записи: 17
20-12-2012 дата публикации

Heatsink Allowing In-Situ Maintenance in a Stackable Module

Номер: US20120320524A1
Автор: El-Essawy Wael R., Elnozahy Elmootazbellah N., IYENGAR Madhusudan K., JR. Thomas W., Keller, Rubio Juan C.
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

A modular processing module allowing in-situ maintenance is provided. The modular processing module comprises a set of processing module sides. Each processing module side comprises a circuit board, a plurality of connectors, and a plurality of processing nodes. Each processing module side couples to another processing module side using at least one connector in the plurality of connectors such that, when all of the set of processing module sides are coupled together, the modular processing module is formed. The modular processing module comprises an exterior connection to a power source and a communication system and at least one heatsink that couples to at least a portion of the plurality of processing nodes on one of the processing module sides and is designed such that, when a set of heatsinks in the modular processing module are installed, an empty space is left in a center of the modular processing module. 1. A modular processing module allowing in-situ maintenance comprising:a set of processing module sides, wherein each processing module side comprises:a circuit board;a plurality of connectors coupled to the circuit board; and an exterior connection to a power source and a communication system; and', 'at least one heatsink that couples to at least a portion of the plurality of processing nodes on one of the processing module sides, wherein the at least one heatsink is designed such that, when a set of heatsinks in the modular processing module are installed, an empty space is left in a center of the modular processing module, wherein the empty space in the center of the processing module is filled with a core that fills an air gap left by the set of heatsinks in the modular processing module, wherein the core is comprised of a plurality of core sections, wherein the plurality of core sections are coupled together using retention mechanisms, and wherein the plurality of core sections are coupled together using expansion mechanisms, and wherein upon release of ...

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Номер записи: 18
27-12-2012 дата публикации

IMMUNOGENIC COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR INDUCING HUMORAL AND CELLULAR IMMUNE RESPONSES

Номер: US20120328655A1
Автор: Dubensky, JR. Thomas W., Robbins Scott H.
Принадлежит: IMMUNE DESIGN CORP.

Compositions and methods are provided herein for improved dual immunization strategies that induce in a subject an immune response that includes a humoral immune response and cellular immune response, both CD4 and CD8 T lymphocyte immune responses, thereby providing a complete adaptive immune response to one or more antigens. The methods described are therefore useful for treating and/or preventing (i.e., reducing the likelihood or risk of occurrence) different diseases, disorders, and conditions such as cancers and infectious diseases for which induction of both a humoral immune response and cellular immune response is desired and beneficial. 1. A method for inducing an immune response in a subject , the method comprising (a) administering to the subject at least one dose of a first immunogenic composition comprising at least a first immunogen , wherein the at least one dose of a first immunogen is capable of inducing an immune response specific for a first designated antigen; and (b) administering to the subject at least one dose of a second immunogenic composition comprising a recombinant expression vector comprising a nucleotide sequence that encodes the first immunogen ,thereby inducing an immune response specific for the first designated antigen.2. The method of claim 1 , wherein the first immunogen is a first polypeptide claim 1 , and said nucleotide sequence encodes a second polypeptide that is different from the first polypeptide.3. The method of claim 1 , wherein (i) the first immunogenic composition further comprises an adjuvant; (ii) the second composition further comprises an adjuvant; or (iii) each of the first composition and the second composition further comprises an adjuvant.4. The method of claim 3 , wherein the second immunogenic composition is administered subsequent to administration of the first immunogenic composition.5. The method of claim 3 , wherein the second immunogenic composition is administered prior to administration of the first ...

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Номер записи: 19
10-01-2013 дата публикации

TOUCHPAD AND PICK BUTTON ASSEMBLY

Номер: US20130009898A1
Автор: Brock John, DEGNER Brett William, JR. Thomas W., Ligtenberg Chris, Mathew Dinesh, Wilson
Принадлежит: Apple Inc.

A touchpad assembly for use in an electronic device is provided. The touchpad assembly may include a touchpad frame operative to be placed within an opening in an electronic device frame. The touchpad assembly may include a support plate for supporting a touchpad, and a bracket for receiving a pick button. The support plate and bracket may be manufactured into a same component to increase the rigidity of the touchpad assembly. The pick button may include a varying height to prevent the pick button from deflecting and to make the pick button travel for providing a selection instruction uniform. The pick button may be coupled to the frame using any suitable approach, including using springs connected the ends of the pick button to the frame. The frame may also include pads to muffle the sound of the pick button when it returns to its initial position after having been pressed. 118-. (canceled)19. An electronic device comprising:a housing comprising an opening;a pick button positioned within the opening; and a first end of the first spring is attached to the pick button; and', 'a second end of the first spring is attached to the housing., 'a first spring, wherein20. The electronic device of claim 19 , wherein at least one of:the first end of the first spring is directly connected to the pick button; andthe second end of the first spring is directly connected to the housing.21. The electronic device of claim 19 , wherein:the first end of the first spring is directly connected to the pick button; andthe second end of the first spring is directly connected to the housing.22. The electronic device of claim 19 , further comprising a second spring claim 19 , wherein:the first end of the first spring is attached to a first end of the pick button;the second end of the first spring is attached to the housing adjacent a first side of the opening;a first end of the second spring is attached to a second end of the pick button; anda second end of the second spring is attached to ...

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Номер записи: 20
28-02-2013 дата публикации

SENSOR-SWARM ENVIRONMENTAL EVENT DETECTION

Номер: US20130054032A1
Автор: El-Essawy Wael, Hanson Heather L., JR. Thomas W., Keller, Rubio Juan C.
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

Data center environmental sensing is provided by a measurement system that detects environmental events from inputs received from a plurality of movable sensors. The sensors are moved in response to detection of an event to a region of the data center associated with the event, providing increased spatial resolution of the measurement in the region of the event. Events such as leakage between hot and cold aisles of a data center can be detected by the system, which may use one or more movable devices that can be moved around, between and over equipment, to carry multiple sensors toward the source of the event, providing both diagnostic and detailed environmental information. 1. A system for evaluating an environmental event in a data center , the system comprising:multiple movable sensors for measuring an environmental parameter associated with the environmental event;a measurement system for receiving outputs of the multiple movable sensors and generating measurement values of the environmental parameter, wherein the measurement system detects the environmental event from the measurement values; anda controller for moving the multiple movable sensors in response to the measurement system detecting the environmental event to increase a spatial resolution of the measurement values in a region of the data center associated with the event.2. The system of claim 1 , further comprising a movable device to which one or more of the multiple movable sensors is affixed claim 1 , wherein the movable device is controlled by the controller to move the movable device proximate to the region of the data center to increase the spatial resolution of the measurement values.3. The system of claim 2 , wherein a plurality of the multiple movable sensors are affixed to the movable device claim 2 , and wherein the multiple movable sensors have fixed spatial relationship with respect to a frame of the movable device.4. The system of claim 2 , further comprising a plurality of fixed ...

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Номер записи: 21
28-02-2013 дата публикации

Branch Circuit Power Measurement and Dynamic Power Distribution

Номер: US20130054981A1
Автор: Allen-Ware Malcolm S., Brey Thomas M., El-Essawy Wael R., Ferreira Alexandre P., JR. Thomas W., Keller
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

A mechanism is provided for dynamically changing power caps for a set of powered elements. Current being consumed by the set of powered elements P on a branch circuit is measured and available current on the branch circuit is determined. A new total power cap for a current time period t is identified based on a current total power cap and the measured current. A difference in total power caps (ΔTPC) is determined and, for each powered element p in the set of powered elements P at the current time period, a new power cap PC (p,t) is determined based on the previous power cap PC(p,t−1) and the difference of the total power caps to the set of powered elements P. A power cap of each powered element p is then dynamically set to the new power cap PC (p,t). 110-. (canceled)11. A computer program product comprising a computer readable storage medium having a computer readable program stored therein , wherein the computer readable program , when executed on a computing device , causes the computing device to:measure current being consumed by a set of powered elements P on a branch circuit;determine available current on the branch circuit;identify a new total power cap for a current time period t based on a current total power cap and the measured current;determine a difference in total power caps (ΔTPC);for each powered element p in the set of powered elements P on the current time period, determine a new power cap PC (p,t) based on the previous power cap PC(p,t−1) and the difference of the total power caps to the set of powered elements P; anddynamically set a power cap of each powered element p to the new power cap PC (p,t).12. The computer program product of claim 11 , wherein the available current on the branch circuit is determined by subtracting the measured current on the branch circuit from a branch circuit capacity current value.13. The computer program product of claim 11 , wherein the power cap of each powered element p is set in response to a failure in at least ...

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Номер записи: 22
28-02-2013 дата публикации

Branch Circuit Power Measurement and Dynamic Power Distribution

Номер: US20130054985A1
Автор: Allen-Ware Malcolm S., Brey Thomas M., El-Essawy Wael R., Ferreira Alexandre P., JR. Thomas W., Keller
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

A mechanism is provided for dynamically changing power caps for a set of powered elements. Current being consumed by the set of powered elements P on a branch circuit is measured and available current on the branch circuit is determined. A new total power cap for a current time period t is identified based on a current total power cap and the measured current. A difference in total power caps (ΔTPC) is determined and, for each powered element p in the set of powered elements P at the current time period, a new power cap PC (p,t) is determined based on the previous power cap PC(p,t−1.) and the difference of the total power caps to the set of powered elements P. A power cap of each powered element p is then dynamically set to the new power cap PC (p,t). 1. A method , in a data processing system , for dynamically changing power caps for a set of powered elements , the method comprising:measuring current being consumed by the set of powered elements P on a branch circuit;determining available current on the branch circuit;identifying a new total power cap for a current time period t based on a current total power cap and the measured current;determining a difference in total power caps (ΔTPC);for each powered element p in the set of powered elements P at the current time period, determining a new power cap PC (p,t) based on the previous power cap PC(p,t−1) and the difference of the total power caps to the set of powered elements P; anddynamically setting a power cap of each powered demerit p to the new power cap PC (p,t).2. The method of claim 1 , wherein the available current on the branch circuit is determined by subtracting the measured current on the branch circuit from a branch circuit capacity current value.3. The method of claim 1 , wherein the power cap of each powered element p is set in response to a failure in at least one of a primary power controller or a redundant power controller.4. The method of claim 1 , wherein identifying the new total power cap for ...

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Номер записи: 23
28-03-2013 дата публикации

CIRCUMVENTING FREQUENCY EXCITATIONS IN A COMPUTER SYSTEM

Номер: US20130079933A1
Автор: AIELLO Anthony J., Dybenko Jesse T., JR. Thomas W., Patton Brad Lee, Phan Con D., Tan Cheng P., Wilson
Принадлежит: Apple Inc.

The described embodiments relate generally to control of rotational components in a computer system. In one embodiment, the rotational component includes a cooling fan assembly, the cooling fan assembly being controlled in accordance with resonant frequency avoidance data. The resonant frequency avoidance data being characteristic of the computer system such that when the cooling fan assembly operates in accordance with the resonant frequency avoidance data, the cooling fan assembly does not operate at a fan speed that is coincident with a natural resonant frequency of the computer system. 1. A method for operating a computing system having a mechanical component with at least one rotational aspect and a processor , the mechanical component controlled by the processor , the method comprising:determining by the processor if the first operating state coincides with a resonant frequency of the computing system; andpreventing the computing system from operating at the resonant frequency by modifying by the processor the first operating state of the mechanical component to a second operating state that avoids the resonant frequency of the computing system.2. The method as recited in claim 1 , the determining comprising:sensing a physical response of the computing system in accordance with the first operating state of the mechanical component by a sensor, and if the physical response exceeds a threshold level, then the first operating state coincides with the resonant frequency of the computing system.3. The method as recited in claim 2 , when the first operating state coincides with the resonant frequency of the computing system then modifying the first operating state by the processor by accessing resonant frequency avoidance data claim 2 , the resonant frequency avoidance data including data used by the processor to modify the first operating state of the computing system to the second operating state to avoid the resonant frequency.4. The method as recited in claim 3 ...

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Номер записи: 24
04-04-2013 дата публикации

SEMICONDUCTOR WAFER TREATMENT SYSTEM

Номер: US20130084147A1
Автор: Abiva Julius R., JR. Thomas W., Marques Paulo J., Moran, Nolan Michael P.
Принадлежит: DENTON VACUUM, L.L.C.

A wafer treatment system including a load lock chamber in communication with a process chamber. At least one cradle is provided in the load lock chamber, each cradle being adapted to receive a wafer-holding cassette. The wafers contained in the cassettes assume angularly justified positions. A multiaxial transfer unit picks up wafers from the cassettes and delivers them to the process chamber for treatment after which they are returned to the cassettes. Because all of the wafers lean in the same direction and to the same degree in their cassette slots, an end effector carried by the multiaxial transfer unit can reliably capture and release the wafers in order to consistently remove them from and place them into the cassettes. 1. Wafer handling apparatus comprising:at least one sloped cassette having a first end and a second end; andmeans for removing wafers from and placing wafers into said at least one cassette.2. The apparatus of further comprising a carousel claim 1 , said at least one cassette being carried by said carousel.3. The apparatus of wherein said first end is a radially proximal end and said second end is a radially distal end.4. The apparatus of wherein said at least one cassette slopes downwardly from said radially proximal end to said radially distal end.5. The apparatus of wherein said carousel rotates about a substantially vertical rotation axis.6. The apparatus of wherein said means for removing and placing wafers comprises a multiaxial transfer unit including x-axis and z-axis transfer mechanisms and means for holding wafers.7. The apparatus of wherein said x-axis transfer mechanism is disposed at an angle corresponding to the slope of said at least one cassette.8. Wafer handling apparatus comprising:at least one sloped cradle having a first end and a second end;at least one cassette received in said at least one cradle; andmeans for removing wafers from and placing wafers into said at least one cassette.9. The apparatus of further comprising a ...

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Номер записи: 25
20-06-2013 дата публикации

Electronic Device With Backlit Display

Номер: US20130155351A1
Автор: Augenbergs Peteris K., Garelli Adam T., Hendren Keith J., JR. Thomas W., Mathew Dinesh C., Posner Bryan W., Qi Jun, Wilson, Yin Victor H.
Принадлежит:

An electronic device may have a liquid crystal display with backlight structures. The backlight structures may produce backlight that passes through display layers in the display. The display layers may include color filter elements, a liquid crystal layer, and a thin-film transistor layer. The color filter elements may be interposed between the thin-film transistor layer and the backlight structures or the thin-film transistor layer may be interposed between the color filter elements and the backlight structures. The backlight structures may be formed from optical fiber, a two-dimensional array of light-emitting diodes, a light guide plate that includes a rectangular recess for receiving optical films, or light guide plate structures that include internal light scattering structures. A light guide plate may be provided with alignment features that mate with alignment features on optical films. 1. A display , comprising:an outer display layer;an inner display layer;a two-dimensional light-emitting diode array that produces display backlight; anda layer of liquid crystal material between the outer display layer and the inner display layer, wherein the outer display layer comprises a substrate and comprises thin-film transistors, wherein the inner display layer is interposed between the layer of liquid crystal material and the two-dimensional light-emitting diode array.2. The display defined in wherein the inner display layer comprises a color filter array layer.3. The display defined in further comprising a layer of color filter elements on the substrate claim 1 , wherein the thin-film transistors are interposed between the color filter elements and the substrate.4. The display defined in wherein the inner display layer comprises a polarizer layer.5. The display defined in wherein the two-dimensional array of light-emitting diodes comprises an array of vertically mounted light-emitting diodes mounted on a substrate in rows and columns.6. The display defined in ...

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Номер записи: 26
27-06-2013 дата публикации

Keyboard Mechanisms for Electronic Devices

Номер: US20130161171A1
Автор: BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Niu James J., Wilson
Принадлежит: Apple Inc.

An input device configured to communicate with a computing device includes at least one keycap, a support mechanism operably connected to the keycap and configured to move the keycap from a first position to a second position, and a feature plate operably connected to the support mechanism. The support mechanism includes a first support and a second support. The first support and the second support are each connected to the at least one keycap and the feature plate. The first support and second support pivot to allow vertical movement of the keycap but lateral movement of the first support and second support are restricted. 1. An input device configured to communicate with a computing device comprising:at least one keycap;a support mechanism operably connected to the keycap and configured to move the keycap from a first position to a second position; anda feature plate operably connected to the support mechanism;wherein the support mechanism comprises a first support connected to the at least one keycap and the feature plate and a second support connected to the at least one keycap and the feature plate wherein the first support and second support pivot to allow vertical movement of the keycap but lateral movement of the first support and second support are restricted.2. The input device of claim 1 , wherein the first support and the second support comprise a rigid material.3. The input device of claim 2 , wherein the rigid material is more rigid than plastic.4. The input device of claim 2 , wherein the rigid material comprises at least one of glass filled plastic claim 2 , metal coated plastic claim 2 , cast metal claim 2 , metal injection molded material claim 2 , metal claim 2 , or machined metal.5. The input device of claim 1 , wherein the first support and second support are connected by a locking member that creates a pivot point for the first support and the second support.6. The input device of claim 5 , wherein the locking member prevents lateral movement ...

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Номер записи: 27
27-06-2013 дата публикации

Keyboard with Position Sensing Mechanism

Номер: US20130161172A1
Автор: BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Leung Omar Sze, Niu James J., Patton Brad, Wilson
Принадлежит: Apple Inc.

An input device configured to communicate with a computing device includes at least one keycap, a support mechanism operably connected to the keycap and configured to move the keycap from a first position to a second position, a feature plate operably connected to the support mechanism, and a sensing member. The sensing member is configured to detect at least one of a change of position of the at least one keycap, a speed of the at least one keycap, an amount of force applied to the at least one keycap, or a location of a finger. The sensing member may be a capacitive sensor. In some embodiments, the input device may not include the support mechanism and the sensing member may be configured to detect the location of a finger regardless whether or not the keycap moves. 1. An input device configured to communicate with a computing device comprising:at least one keycap;a support mechanism operably connected to the keycap and configured to move the keycap from a first position to a second position;a feature plate operably connected to the support mechanism; anda sensing member configured to detect at least one of a change of position of the at least one keycap, a speed of the at least one keycap, an amount of force applied to the at least one keycap, or a location of a finger.2. The input device of claim 1 , wherein the sensing member is a capacitive sensor.3. The input device of claim 2 , wherein the sensing member interacts with at least one component of the input device to detect changes in capacitance in order to detect the at least one of the change of position of the at least one keycap claim 2 , the speed of the at least one keycap claim 2 , the amount of force applied to the at least one keycap claim 2 , or the location of the finger.4. The input device of claim 3 , wherein the at least one component of the input device includes at least one of metal or a layer of sensing material.5. The input device of claim 3 , wherein the at least one component of the input ...

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Номер записи: 28
27-06-2013 дата публикации

Illuminated Keyboard

Номер: US20130162450A1
Автор: BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Niu James J., Patton Brad, Wilson
Принадлежит: Apple Inc.

In a first embodiment, an input device includes at least one keycap, a support mechanism configured to move the keycap from a first position to a second position, a feature plate having at least one anchoring mechanism operably connected to the support mechanism, and an illumination panel. The illumination panel is positioned between the at least one keycap and the feature plate. The at least one anchoring member extends through a portion of the illumination panel. In a second embodiment, an input device includes a keycap, a support mechanism configured to move the keycap, a support plate operably connected to the support mechanism, and an illumination panel. The illumination panel includes a light source, a light guide, and a frame substantially surrounding the light guide. Light illuminated from the light source is directed by the light guide and the frame towards the keycap. 1. An input device configured to communicate with a computing device comprising:at least one keycap;a support mechanism operably connected to the keycap and configured to move the keycap from a first position to a second position;a feature plate having at least one anchoring mechanism operably connected to the support mechanism; andan illumination panel operably connected to the support mechanism and in optical communication with at least a portion of the at least one keycap; whereinthe illumination panel is positioned between the at least one keycap and the feature plate; andthe at least one anchoring member extends through a portion of the illumination panel.2. The input device of claim 1 , wherein the feature plate further includes at least one channel and the illumination panel is positioned within the channel.3. The input device of claim 2 , wherein the channel comprises a base member claim 2 , a first angled extension that extends upwardly at an angle from a first side of the base member claim 2 , a second angled extension that extends upwardly at an angle from a second side of the base ...

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Номер записи: 29
11-07-2013 дата публикации

Displays with Liquid Crystal Shutters

Номер: US20130176512A1
Автор: Adam T. Garelli, Bryan W. Posner, Carl R. Peterson, Dinesh C. Mathew, Jun Qi, Keith J. Hendren, Peteris K. Augenbergs, Stephen R. McClure, Thomas W. Wilson, JR., Victor H. Yin
Принадлежит: Apple Inc

An electronic device may have a display such as a liquid crystal display. The display may have an array of display pixels. The array of display pixels may display images for a user in an active area of the display. An inactive area of the display may surround the active area. An opaque masking layer may be provided in the inactive area to block internal components in the electronic device from view. An optical component such as a light-based proximity sensor, ambient light sensor, image sensor, or light-emitting status indicator may be aligned with an opening in the opaque masking layer. A liquid crystal shutter may be provided in the display. The liquid crystal shutter may be controlled by control circuitry in the electronic device. The liquid crystal shutter may be aligned with the opening in the opaque masking layer in the inactive area and with the optical component.

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Номер записи: 30
26-09-2013 дата публикации

Electronic Device with Inverted Liquid Crystal Display

Номер: US20130250202A1
Автор: Adam T. Garelli, Bryan W. Posner, Dinesh C. Mathew, Jun Qi, Keith J. Hendren, Peteris K. Augenbergs, Thomas W. Wilson, JR., Victor H. Yin
Принадлежит: Apple Inc

An electronic device may have a liquid crystal display with backlight structures. The backlight structures may produce backlight that passes through an array of display pixels. The display pixels may include electrode structures and thin-film transistor structures for controlling electric fields in a layer of liquid crystal material. The liquid crystal material may be formed between an outer display layer and an inner display layer. The inner display layer may be interposed between the backlight structures and the liquid crystal material. Thin-film transistor structures, electrodes, and conductive interconnection lines may be deposited in a layer on the inner surface of the outer display layer. A layer of color filter elements may be used to provide the display with color pixels. The color filter elements may be formed on top of the thin-film transistor layer or on a separate color filter array substrate such as the inner display layer.

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Номер записи: 31
03-10-2013 дата публикации

Surgical stapler

Номер: US20130256384A1
Автор: Dominick L. Mastri, Frank J. Viola, Jon Wilson, Robert J. Geiste, Thomas W. Alesi, Jr.
Принадлежит: COVIDIEN LP

A surgical device is described herein that can be used to fire different types and sizes of disposable loading units. In a preferred embodiment, the device applies parallel rows of surgical fasteners to body tissue and concomitantly forms an incision between the rows of staples during an endoscopic or laparoscopic surgical procedure. The device can be utilized with disposable loading units configured to apply linear rows of staples measuring from about 15 mm in length to about 60 mm in length and can be used to fire disposable loading units containing surgical clips and individual staples.

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Номер записи: 32
31-10-2013 дата публикации

MOVABLE TRACK PAD WITH ADDED FUNCTIONALITY

Номер: US20130285984A1
Автор: Andre Bartley K., CASEBOLT Matthew P., Degner Brett W., JR. Thomas W., KESSLER Patrick, LIGTENBERG Christiaan A., Wilson
Принадлежит: Apple Inc.

An input device is disclosed. The input device includes a movable touch-sensitive track pad capable of detecting an object in close proximity thereto so as to generate a tracking control signal. The input device also includes a movement indicator capable of detecting the movements of the movable track pad so as to generate one or more other control signals (e.g., button signals). The control signals can be used to perform actions in an electronic device operatively coupled to the input device. 1a plurality of protrusions that extend above a top surface of the glass layer, wherein a topmost portion of at least some of the plurality of protrusions cooperate to define a tactile surface with respect to a user's finger, the tactile surface providing an effective barrier between the user's finger and a portion of the top surface of the glass layer disposed between the protrusions that defines an optically transmissive surface configured to provide an optical path for light incident on the glass layer, the effective barrier configured to prevent direct contact between the user's finger and the optically transmissive surface that maintains the integrity of the optical path by preventing user finger induced smudging.. A glass layer disposed above a touch sensitive sensor, the glass layer comprising: This U.S. patent application is a continuation of co-pending U.S. application Ser. No. 12/241,967 filed Sep. 30, 2008 and entitled “MOVABLE TRACK PAD WITH ADDED FUNCTIONALITY” which is incorporated by reference in its entirety for all purposes.1. Field of the InventionThe present invention relates generally to track pads. More particularly, the present invention relates to track pads capable of relative movement in order to increase the functionality of the track pad.2. Background ArtThere exist today many styles of input devices for performing operations in a consumer electronic device. The operations generally correspond to moving a cursor and making selections on a display ...

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Номер записи: 33
28-11-2013 дата публикации

METHOD AND APPARATUS FOR PROVIDING A VOIP SERVER IN A WIRELESS INTEGRATED DEVICE

Номер: US20130315147A1
Автор: BARZEGAR FARHAD, Gerszberg Irwin, Hill, JR. Thomas W., Mollica Scott
Принадлежит: AT&T INTELLECTUAL PROPERTY II, L.P.

A method and apparatus for handling a call using a wireless integrated access device that is compatible with Voice over ATM and Voice over DSL on a network side while being compatible with VoIP on a customer premise side are disclosed. For example, the present method employs a wireless integrated access device for receiving an incoming call from a broadband access network that uses dedicated connection switching. In turn, the method establishes a wireless connection for the incoming call with at least one VoIP enabled endpoint device located at a customer premise. 1. A method for handling an incoming call , comprising:receiving, via a wireless integrated access device, the incoming call from a broadband access network that uses dedicated connection switching, wherein the dedicated connection switching is implemented over a digital subscriber loop network, wherein the wireless integrated access device is deployed at a customer premises;establishing, via the wireless integrated access device, a wireless connection for the incoming call with a plurality of voice over internet protocol enabled endpoint devices located at the customer premises for enabling a user to directly answer the incoming call using any one of the plurality of voice over internet protocol enabled endpoint devices, wherein the incoming call is routed directly from the wireless integrated access device to any one of the plurality of voice over internet protocol enabled endpoint devices used by the user to directly answer the incoming call; andproviding a notification to the plurality of voice over internet protocol enabled endpoint devices to indicate a presence of the incoming call.2. The method of claim 1 , wherein the broadband access network comprises a fiber network.3. The method of claim 1 , wherein the plurality of voice over Internet protocol enabled endpoint devices comprises a plurality of wireless computing devices.4. The method of claim 1 , wherein the notification comprises a visible ...

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Номер записи: 34
05-12-2013 дата публикации

TREATMENT OF AMD USING AAV SFLT-1

Номер: US20130323302A1
Автор: Chalberg, Constable Ian J., JR. Thomas W., Lai Chooi-May, Rakoczy Elizabeth P.
Принадлежит:

The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by administering subretinally a pharmaceutical composition comprising a pharmaceutically effective amount of a vector comprising a nucleic acid encoding soluble Fms-related tyrosine kinase-1 (sFlt-1) protein to the human subject. 1. A method for the treatment or prophylaxis of ocular neovascularization in a human subject comprising: administering to one or more subretinal sites a pharmaceutically effective amount of a pharmaceutical composition comprising a nucleic acid encoding sFLT-1 to a human subject in need of treatment.2. The method of claim 1 , wherein the human subject has or is suspected of having one or more conditions selected from the group consisting of: age-related macular degeneration (AMD) claim 1 , wet-AMD claim 1 , dry-AMD claim 1 , retinal neovascularization claim 1 , choroidal neovascularization and diabetic retinopathy.3. The method of claim 1 , wherein the human subject has or is suspected of having one or more conditions selected from the group consisting of: proliferative diabetic retinopathy claim 1 , retinal vein occlusion claim 1 , central retinal vein occlusion claim 1 , branched retinal vein occlusion claim 1 , diabetic macular edema claim 1 , diabetic retinal ischemia claim 1 , ischemic retinopathy and diabetic retinal edema.4. The method of claim 1 , wherein the pharmaceutical composition comprises a recombinant virus claim 1 , the virus selected from the group consisting of: adeno-associated virus (AAV) claim 1 , adenovirus claim 1 , helper-dependent adenovirus claim 1 , retrovirus claim 1 , herpes simplex virus claim 1 , lentivirus claim 1 , poxvirus claim 1 , hemagglutinatin virus of Japan-liposome (HVJ) complex claim 1 , Moloney murine leukemia virus claim 1 , and HIV-based virus.5. The method of claim 1 , wherein the sFLT-1 nucleic acid encodes at least 1 dimerization domain.6. The ...

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Номер записи: 35
20-03-2014 дата публикации

Flexible Data Cable

Номер: US20140076607A1
Автор: BROCK John M., DEGNER Brett William, Hendren Keith J., JR. Thomas W., Keiper Stever D., Kim Eugene Y., Ligtenberg Chris, Mathew Dinesh C., Wilson
Принадлежит: Apple Inc.

A multi-layered cable consisting of three or more conductive layers separated by layers of dielectric and/or adhesive material. The bottom layer and the top layer may act as return path for the transmitted signals and as a shield to prevent interference between these and external electrical signals. Located between the bottom layer and the top layer, the middle layer may transmit desired signals through the flexible cable. The material selection and specifics of each of the layers should be selected so as to achieve a balance in which the desired electrical impedance and mechanical flexibility requirements are met. The cable may also include one or more vias connecting the bottom layer to the top layer, providing shielding all the way around the flex cable. An additional conductive sock may be used to improve shielding effectiveness of the top and bottom layer and to connect to I/O connector shells and the system Faraday cage. 1. A flexible data cable comprising:a bottom layer;a top layer;a middle layer located between the top layer and bottom layer;at least one data transmission line located adjacent to the middle layer; and a hole in the cable from the top layer to the bottom layer; and', 'a conductive filling, wherein the conductive filling electrically couples the bottom layer and the top layer., 'at least one via, the via comprising;'}2. The data cable of wherein the bottom layer and the top layer provide ground planes for the cable.3. The data cable of wherein the via is located near the edge of the cable.4. The data cable of further comprising:a first conductive sock placed above the top layer; anda second conductive sock placed below the bottom layer.5. The data cable of wherein the first conductive sock and the second conductive sock extend past the edge of the cable to surround the cable.6. The data cable of further comprising:a metal pad that surrounds the cable and electrically couples to the top layer and the bottom layer.7. The data cable of wherein ...

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Номер записи: 36
27-03-2014 дата публикации

VACCINES FOR HSV-2

Номер: US20140086947A1
Автор: Dubensky, Hosken Nancy A., JR. Thomas W., Moore Margaret D., Robbins Scott H.
Принадлежит: IMMUNE DESIGN CORP.

Compositions of recombinant HSV-2 proteins and an agonist of the innate immune system, such as an adjuvant, are provided as a vaccine. Proteins include an envelope glycoprotein and a structural protein other than an envelope glycoprotein, e.g., a capsid or tegument protein. The vaccine is for use in either HSV-2 seropositive or seronegative subjects. 1. An immunogenic fragment of an HSV-2 polypeptide selected from the group consisting of:(a) an immunogenic fragment of UL19 polypeptide lacking at least 75% of amino acids 1-450 of SEQ ID NO: 4 and lacking at least 75% of amino acids of 1055-1374 of SEQ ID NO: 4;(b) the sequence set out in SEQ ID NO: 12;(c) an immunogenic variant of (a) or (b) that retains at least 85% amino acid identity over at least 15 contiguous amino acids;(d) an immunogenic fragment of (a) or (b); and(e) a chimeric fusion of (a), (b) (c) or (d).2. An isolated polynucleotide encoding the polypeptide of .3. An immunogenic claim 1 , pharmaceutical composition comprising: (a) an immunogenic fragment of UL19 polypeptide lacking at least 75% of amino acids 1-450 of SEQ ID NO: 4 and lacking at least 75% of amino acids of 1055-1374 of SEQ ID NO: 4;', '(b) the sequence set out in SEQ ID NO: 12;', '(c) an immunogenic variant of (a) or (b) that retains at least 85% amino acid identity over at least 15 contiguous amino acids;', '(d) an immunogenic fragment of (a) or (b); and', '(e) a chimeric fusion of (a), (b) or (c);, '(i) an immunogenic fragment of an HSV-2 polypeptide selected from the group consisting of(ii) optionally, an agent that activates innate immunity; and(iii) a pharmaceutically acceptable carrier.4. The composition of which further comprises UL25 or an immunogenic fragment thereof.5. The composition of any one of and which further comprises gD2 or an immunogenic fragment thereof.65. The composition of any of - wherein the agent is an adjuvant.7. The composition of wherein the adjuvant is GLA.8. The composition of wherein the GLA is in the form ...

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Номер записи: 37
10-04-2014 дата публикации

Statistical Determination of Power-Circuit Connectivity

Номер: US20140100804A1
Автор: El-Essawy Wael R., Ferreira Alexandre P., JR. Thomas W., Keller, Nassif Sani R., Rajamani Karthick, Rubio Juan C.
Принадлежит: INTERNATIONAL BUSINESS MACHINES CORPORATION

A mechanism is provided for statistical determination of power circuit connectivity based on signal detection in a circuit. Signal data from the circuit gathered and a determination is made as to whether a signal of interest is present in the gathered signal data from the circuit using a statistical analysis of the gathered signal data. The statistical analysis comprises using a mean current value and statistical deviation of the current value of the signal data over a predetermined period of time to compute a confidence range. The confidence range is compared to a first threshold and a second threshold. A determination is made that the signal is present in response to the confidence range being above the first threshold. A determination is made that the signal is not present in response to the confidence range being below the second threshold. 1. A method , in a data processing system , for statistical determination of power circuit connectivity based on signal detection in a circuit , comprising:gathering signal data from the circuit; anddetermining whether a signal of interest is present in the gathered signal data from the circuit using a statistical analysis of the gathered signal data, wherein the statistical analysis comprises using a mean current value and statistical deviation of the current value of the signal data over a predetermined period of time to compute a confidence range and comparing the confidence range to a first threshold and a second threshold, wherein a determination that the signal is present is made in response to the confidence range being above the first threshold, and wherein a determination that the signal is not present is made in response to the confidence range being below the second threshold.2. The method of claim 1 , wherein a lower bound of the confidence range is used to determine whether the signal is present.3. The method of claim 1 , wherein a higher bound of the confidence range is used to determine whether the signal is ...

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Номер записи: 38
04-01-2018 дата публикации

ENGINEERED LISTERIA AND METHODS OF USE THEREOF

Номер: US20180000917A1
Автор: Cook David N., Dubensky, JR. Thomas W., Lauer Peter M., Skoble Justin
Принадлежит: Aduro Biotech, Inc.

The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes. 1(a) recombinantly introducing a bacterial attachment site (attBB′) which is not present in the bacterial genome into a pre-determined site of the genome of a population of bacteria; (i) a first nucleic acid sequence encoding a first recombinase binding site heterologous to the bacterial genome and a second nucleic acid sequence encoding a second recombinase binding site heterologous to the bacterial genome, wherein the first and second recombinase binding sites are two Lox sites or two Frt sites,', '(ii) a third nucleic acid sequence encoding a selection marker, wherein the first and second recombinase binding sites flank the third nucleic acid sequence encoding a selection marker,', '(iii) a fourth nucleic acid sequence encoding a phage integrase selected to mediate integration at the first bacterial attachment site, wherein the first and second recombinase binding sites flank the fourth nucleic acid sequence,', '(iv) a fifth nucleic acid sequence not flanked by the recombinase binding sites, the fifth nucleic acid sequence encoding the heterologous nucleic acid sequence of interest, and', '(v) a sixth nucleic acid sequence not flanked by the recombinase binding sites, the sixth nucleic acid sequence encoding a phage attachment site (attPP′) site compatible with first bacterial attachment site,, '(b) contacting the population of bacteria with a plasmid comprising'}under conditions selected to cause integration of the plasmid into the pre-determined site of the genome mediated by the phage integrase, wherein the plasmid lacks an origin of replication that is active in the bacteria;(c) selecting bacteria from the population of bacteria which have integrated the plasmid into the pre- ...

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Номер записи: 39
01-01-2015 дата публикации

Treatment of amd using aav sflt-1

Номер: US20150004101A1
Автор: Chooi-may LAI, Ian J. CONSTABLE, P. Elizabeth Rakoczy, Thomas W. Chalberg, Jr.
Принадлежит: Avalanche Australia Pty Ltd

The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by administering subretinally a pharmaceutical composition comprising a pharmaceutically effective amount of a vector comprising a nucleic acid encoding soluble Fms-related tyrosine kinase-1 (sFlt-1) protein to the human subject.

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Номер записи: 40
05-01-2017 дата публикации

LOW-TRAVEL KEY MECHANISMS WITH BUTTERFLY HINGES

Номер: US20170004937A1
Автор: Berg Bruce E., BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Niu James J., Wilson
Принадлежит:

A key mechanism can include one or more butterfly hinges. Each butterfly hinge includes a double wing design operative to move between a depressed position and non-depressed position. Hinged coupling mechanisms couple respective arms of the wings together. 127-. (canceled)28. A key mechanism , comprising:a keycap;a substrate; and a first wing;', 'a second wing; and', 'a living hinge flexibly coupling the first wing to the second wing., 'a butterfly hinge movably coupling the keycap to the substrate, the butterfly hinge comprising29. The key mechanism of claim 28 , wherein:the first wing comprises a first arm extending towards the second wing;the second wing comprises a second arm extending towards the first wing; andthe living hinge joins an end of the first arm to an end of the second arm.30. The key mechanism of claim 29 ,the first arm and the second arm each comprise retention features; andthe living hinge conforms to the retention features to retain the living hinge to the first arm and the second arm.31. The key mechanism of claim 30 , wherein:the first wing and the second wing comprise a first polymer; andthe living hinge comprises a second polymer that is more flexible than the first polymer.32. The key mechanism of claim 31 , wherein the second polymer is an elastomer.33. The key mechanism of claim 31 , wherein the retention features comprise protrusions.34. The key mechanism of claim 29 , wherein:the living hinge is a first living hinge;the key mechanism further comprises a second living hinge;the first wing comprises a third arm extending towards the second wing;the second wing comprises a fourth arm extending towards the first wing; andthe second living hinge joins an end of the third arm to an end of the fourth arm.35. A hinge mechanism for an input key claim 29 , comprising:a first hinge member defining a first arm;a second hinge member defining a second arm and positioned opposite the first hinge member; anda flexible member at least partially ...

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Номер записи: 41
09-01-2020 дата публикации

USING BINOCULAR RIVALRY FOR EXPANDING COLOR PERCEPTION

Номер: US20200012125A1
Автор: Chalberg, JR. Thomas W.
Принадлежит:

An article includes a first ophthalmic lens including a first spectral filter (e.g., a reflective or absorptive spectral filter), and a second ophthalmic lens including a second spectral filter (e.g., a reflective or absorptive spectral filter). The first spectral filter substantially blocks visible light having wavelengths corresponding to a first portion of a spectral sensitivity range of a first type of cone (e.g., S, M, or L cone) and substantially passes visible light having wavelengths in a second, non-overlapping portion of the spectral sensitivity range. The second spectral filter substantially blocks visible light having wavelengths in the second portion of the spectral sensitivity range and substantially passes visible light having wavelengths in the first spectral sensitivity range. 1. An article , comprising:a first ophthalmic lens comprising a first spectral filter; anda second ophthalmic lens comprising a second spectral filter,wherein the first spectral filter substantially blocks visible light having wavelengths corresponding to a first portion of a spectral sensitivity range of a first type of cone and substantially passes visible light having wavelengths in a second, non-overlapping portion of the spectral sensitivity range, andthe second spectral filter substantially blocks visible light having wavelengths in the second portion of the spectral sensitivity range and substantially passes visible light having wavelengths in the first spectral sensitivity range.2. The article of claim 1 , wherein the article is eyeglasses claim 1 , a pair of contact lenses claim 1 , goggles claim 1 , or a pair of intraocular lenses.3. The article of claim 1 , wherein the first and second spectral filters are a low-pass filter and a high-pass filter claim 1 , respectively.4. The article of claim 1 , wherein at least one of the first and second spectral filters is a notch filter.5. The article of claim 1 , wherein at least one of the first and second spectral filters ...

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Номер записи: 42
17-01-2019 дата публикации

METHODS AND COMPOSITIONS USING LISTERIA FOR ENHANCING IMMUNOGENICITY BY PRIME BOOST

Номер: US20190015488A1
Автор: Bahjat Keith S., Brockstedt Dirk G., Dubensky, JR. Thomas W., Leong Meredith Lai Ling
Принадлежит: Aduro Biotech, Inc.

Provided herein are prime-boost regimens and materials used therein. The prime-boost regimens enhance the immune response to a target antigen. The vaccines used for boost are comprised of recombinant attenuated metabolically active that encodes an expressible antigen that is cross-reactive with the target antigen. In some examples, the immune response is a cellular immune response. 149-. (canceled)50. A method for immunizing a mammal to induce an immune response to a cancer antigen , comprising: (i) administering to the mammal an effective amount of a prime dose of a recombinant adenovirus vector expressing a nucleic acid that encodes an expressible, immunologically active portion of the cancer antigen; and', {'i': 'Listeria', '(ii) following the prime dose administration, administering to the mammal an effective amount of a boost dose of a vaccine comprising an attenuated that encodes the expressible, immunologically active portion of the cancer antigen.'}], 'immunizing the mammal using a prime-boost regimen, wherein the regimen comprises'}51. A method according to claim 50 , wherein the recombinant adenovirus vector is administered intratumorally or peritumorally.52. A method according to claim 50 , wherein the recombinant adenovirus vector is administered intravenously.53Listeria. A method according to claim 50 , wherein the attenuated is administered intravenously.54Listeria. A method according to claim 51 , wherein the attenuated is administered intravenously.55Listeria. A method according to claim 52 , wherein the attenuated is administered intravenously.56. A method according to claim 50 , wherein the cancer antigen is selected from the group consisting of mesothelin claim 50 , PSMA claim 50 , PAP claim 50 , SSX-2 claim 50 , NY-ESO-1 claim 50 , RASG12D claim 50 , RASG12V claim 50 , and RASG13D.57. A method according to claim 51 , wherein the cancer antigen is selected from the group consisting of mesothelin claim 51 , PSMA claim 51 , PAP claim 51 , SSX-2 ...

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Номер записи: 43
03-02-2022 дата публикации

METHODS AND DEVICES FOR REDUCING MYOPIA IN CHILDREN

Номер: US20220035179A1
Автор: Chalberg, Chung Yufen, HONES Peter, I Vanessa Anne, JR. Thomas W., Rappon Joseph Michael, Tasso-Pinas
Принадлежит:

Methods and devices for treating a human child having myopia are disclosed. For example, a human child having myopia can be treated by wearing spectacles having one or two myopia control spectacle lenses. 1. A method for reducing progression of myopia in a human child having , or suspected of having , myopia , the method comprising:identifying the human child having, or suspected of having, myopia; andtreating the human child with spectacles comprising at least one myopia control spectacle lens, wherein said myopia control spectacle lens provides normal visual acuity to the human child when viewed through a central region of the lens and reduced visual acuity for the when viewed through a peripheral region of the lens, and wherein said myopia control spectacle lens reduces myopia progression in the human child by 0.4 D or more after three years of treatment compared to a control group.2. (canceled)3. The method of claim 1 , wherein the reduced visual acuity is provided by a dot pattern in the peripheral region of the lens.45-. (canceled)6. The method of claim 1 , wherein treating the human child comprises treating both of the human child's eyes with corresponding myopia control spectacle lenses.7. (canceled)8. The method of claim 1 , wherein claim 1 , at the time of the identifying claim 1 , the human child is younger than 12 years old.910-. (canceled)11. The method of claim 8 , wherein claim 8 , at the time of the identifying claim 8 , the human child is 6 to 10 years old.1213-. (canceled)14. The method of claim 1 , wherein the myopia control spectacle lens comprises (i) a clear center claim 1 , and (ii) a surrounding annular region claim 1 , both (i) and (ii) substantially centered on a lens axis claim 1 , the clear aperture corresponding to the central region and the annular region corresponding to the peripheral region and comprising one or more features that reduce the visual acuity for the corresponding eye.15. The method as in of claim 14 , wherein the one or ...

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Номер записи: 44
23-01-2020 дата публикации

VACCINES FOR HSV-2

Номер: US20200023057A1
Автор: Dubensky, Hosken Nancy A., JR. Thomas W., Moore Margaret D., Robbins Scott H.
Принадлежит:

Compositions of recombinant HSV-2 proteins and an agonist of the innate immune system, such as an adjuvant, are provided as a vaccine. Proteins include an envelope glycoprotein and a structural protein other than an envelope glycoprotein, e.g., a capsid or tegument protein. The vaccine is for use in either HSV-2 seropositive or seronegative subjects. 1. An immunogenic fragment of an HSV-2 polypeptide selected from the group consisting of:(a) an immunogenic fragment of UL19 polypeptide lacking at least 75% of amino acids 1-450 of SEQ ID NO: 4 and lacking at least 75% of amino acids of 1055-1374 of SEQ ID NO: 4;(b) the sequence set out in SEQ ID NO: 12;(c) an immunogenic variant of (a) or (b) that retains at least 85% amino acid identity over at least 15 contiguous amino acids;(d) an immunogenic fragment of (a) or (b); and(e) a chimeric fusion of (a), (b) (c) or (d).2. An isolated polynucleotide encoding the polypeptide of .3. An immunogenic claim 1 , pharmaceutical composition comprising: (a) an immunogenic fragment of UL19 polypeptide lacking at least 75% of amino acids 1-450 of SEQ ID NO: 4 and lacking at least 75% of amino acids of 1055-1374 of SEQ ID NO: 4;', '(b) the sequence set out in SEQ ID NO: 12;', '(c) an immunogenic variant of (a) or (b) that retains at least 85% amino acid identity over at least 15 contiguous amino acids;', '(d) an immunogenic fragment of (a) or (b); and', '(e) a chimeric fusion of (a), (b) or (c);, '(i) an immunogenic fragment of an HSV-2 polypeptide selected from the group consisting of(ii) optionally, an agent that activates innate immunity; and(iii) a pharmaceutically acceptable carrier.4. The composition of which further comprises (i) UL25 or an immunogenic fragment thereof claim 3 , (ii) gD2 or an immunogenic fragment thereof claim 3 , or (iii) UL25 or an immunogenic fragment thereof and qD2 or an immunogenic fragment thereof.5. (canceled)6. The composition of any of wherein the agent is an adjuvant.7. The composition of wherein ...

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Номер записи: 45
24-01-2019 дата публикации

Feedback Systems for Input Devices

Номер: US20190025926A1
Автор: Dhaval Patel, Jonah A. Harley, Kenneth L. Staton, Patrick KESSLER, Peteris K. Augenbergs, Thomas W. Wilson, JR.
Принадлежит: Apple Inc

An electronic device including a processor, a display screen in communication with the processor, a track pad in communication with the processor including a movable surface that is selectively movable in at least one direction to provide feedback to a user, and a feedback system in communication with the processor including a feedback sensor. The feedback sensor determines a movement characteristic of the movable surface and the processor selectively adjusts at least one setting of the track pad based on the movement characteristic.

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Номер записи: 46
01-02-2018 дата публикации

USE OF STING AGONIST AS CANCER TREATMENT

Номер: US20180028553A1
Автор: Corrales Leticia, Dubensky, Gajewski Thomas F., Glickman Laura Hix, JR. Thomas W., Kanne David, Lemmens Edward Emile, Leong Meredith Lai Ling, Woo Seng-ryong
Принадлежит:

Methods and compositions for treating cancer by intratumorally administering a stimulator of interferon genes (STING) agonist are disclosed herein. 1. A method of treating cancer in a subject comprising administering to the subject an effective amount of a stimulator of interferon genes (STING) agonist , wherein the STING agonist is administered intratumorally.2. The method of claim 1 , wherein the STING agonist is a nucleic acid claim 1 , a protein claim 1 , a peptide claim 1 , or a small molecule.3. The method of claim 2 , wherein the STING agonist is a small molecule.4. The method of claim 3 , wherein the small molecule is a cyclic dinucleotide.6. The method of any of to claim 3 , wherein treating cancer is further defined as reducing the size of a tumor or inhibiting growth of a tumor.7. The method of any of to claim 3 , wherein the STING agonist is administered to the subject at least two claim 3 , three claim 3 , four claim 3 , five claim 3 , six claim 3 , seven claim 3 , eight claim 3 , nine or ten times.8. The method of any of to claim 3 , wherein said subject is further administered a distinct cancer therapy.9. The method of claim 8 , wherein the STING agonist is administered and then the distinct cancer therapy is administered.10. The method of claim 9 , wherein the distinct cancer therapy is administered within 3 days of the STING agonist.11. The method of claim 9 , wherein the distinct cancer therapy is administered within 24 hours of the STING agonist.12. The method of claim 9 , wherein the distinct cancer therapy is administered within 3 hours of the STING agonist.13. The method of claim 8 , wherein the distinct cancer therapy is administered and then the STING agonist is administered.14. The method of claim 13 , wherein the STING agonist is administered within 3 days of the distinct cancer therapy.15. The method of claim 13 , wherein the STING agonist is administered within 24 hours of the distinct cancer therapy.16. The method of claim 13 , wherein ...

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Номер записи: 47
04-02-2016 дата публикации

Water removable compositions and applications thereof

Номер: US20160032116A1
Автор: Bo Wu, Jule W. Thomas, Jr.
Принадлежит: 3D Systems Inc

In one aspect, water removable compositions are described herein, including for use in various printing applications. In some embodiments, a composition described herein comprises 50-95% by weight alcohol wax having the formula CH 3 (CH 2 ) n OH, wherein n is an integer from 15 to 40; 5-50% by weight tackifier; and 0.5-5% by weight colorant. In other instances, a composition described herein comprises 50-95% by weight carboxylic acid wax having the formula CH 3 (CH 2 ) m COOH, wherein m is an integer from 14 to 40; 5-50% by weight tackifier; and 0.5-5% by weight colorant. Additionally, in some cases, the tackifier of a composition described herein comprises a rosin acid, a rosin ester, a rosin alcohol, or a mixture or combination thereof. Further, the solubility of a colorant in a composition described herein can be characterized by a spectral strength delta value of 5% or less or 3% or less.

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Номер записи: 48
01-05-2014 дата публикации

LOW-TRAVEL KEY MECHANISMS USING BUTTERFLY HINGES

Номер: US20140116865A1
Автор: BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Niu James J., Wilson
Принадлежит: Apple Inc.

A key mechanism can include one or more butterfly hinges. Each butterfly hinge includes a double wing design operative to move between a depressed position and non-depressed position. Hinged coupling mechanisms couple respective arms of the wings together. 1. A key mechanism , comprising:a keycap assembly;a support structure; anda butterfly hinge comprising two separate wings positioned adjacent to each other such that a cavity is formed between the two wings, each wing comprising a pair of pivot pins and a pair of keycap assembly pins, wherein the pivot pins are coupled to the support structure and the keycap assembly pins are coupled to the keycap assembly.2. The key mechanism of claim 1 , further comprising a switch secured within the cavity between the keycap assembly and the support structure claim 1 , the switch operative to bias the keycap assembly in a first position.3. The key mechanism of claim 2 , wherein the switch comprises a dome switch operatively connected to a flexible circuit board.4. The key mechanism of claim 1 , wherein the keycap assembly comprises:a keycap; anda substructure coupled to a back surface of the keycap.5. The key mechanism of claim 4 , wherein the substructure comprises a light guide panel.6. The key mechanism of claim 1 , wherein the keycap assembly comprises a plurality of pin retaining members claim 1 , each pin retaining member operative to be coupled to a respective one of the keycap assembly pins.7. The key mechanism of claim 1 , wherein the support structure comprises a plurality of pivot pin retaining members claim 1 , each pivot pin retaining member operative to be securely coupled to a respective one of the pivot pins.8. The key mechanism of claim 1 , further comprising a web that is coupled to the support structure claim 1 , the web dimensioned so that the keycap assembly and the butterfly hinge fit within an interior region of the web.9. The key mechanism of claim 1 , wherein the butterfly hinge comprises two coupling ...

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Номер записи: 49
01-02-2018 дата публикации

Portable computer display structures

Номер: US20180032105A1
Автор: Brett W. Degner, Bryan W. Posner, Chris Ligtenberg, Dinesh C. Mathew, Peteris K. Augenbergs, Thomas W. Wilson, JR., Victor H. Yin
Принадлежит: Apple Inc

An electronic device housing may have upper and lower portions that are attached with a hinge. At least one portion of the housing may have a rear planar surface and peripheral sidewalls having edges. A display module may be mounted in the housing. The display module may have glass layers such as a color filter glass layer and a thin-film transistor substrate. The color filter glass layer may serve as the outermost glass layer in the display module. The edges of the display module may be aligned with the edges of the peripheral housing sidewalls to create the appearance of a borderless display for the electronic device. The display module may be provided with an opening that allows a camera or other electronic components to receive light. Traces may be provided on the underside of the thin-film transistor substrate to serve as signal paths for the electrical components.

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Номер записи: 50
01-05-2014 дата публикации

MULTI-FUNCTIONAL KEYBOARD ASSEMBLIES

Номер: US20140118264A1
Автор: Andre Bartley K., BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Mathew Dinesh C., Niu James J., SILVANTO Mikael, Wilson
Принадлежит: Apple Inc.

Multi-functional keyboard assemblies include an array of keys formed from stacked component layers. A top portion of the key may be capable of travelling vertically with respect to a base of the key. The top portion can include a keycap and a circuitry module coupled to the keycap. The keys may be capable of receive at least two distinct types of inputs and/or receiving at least one type of input and providing at least one type of output. Such output may include use of one or more light sources, displays, and/or haptic feedback devices. 1. A keystack of a keyboard assembly comprising:a base;a keycap;a circuitry module coupled to the keycap; anda support mechanism coupled to the base and at least one of the key cap and the circuitry module, wherein the support mechanism is configured to allow movement of the keycap and the circuitry module with respect to the base.2. The keystack of further comprising a switch claim 1 , wherein the switch is configured to be activated by the movement of the key cap and the circuitry module with respect to the base.3. The keystack of claim 2 , wherein the switch is coupled to the base.4. The keystack of claim 2 , wherein the circuitry module comprises the switch.5. The keystack of claim 4 , wherein:the circuitry module further comprises a flex, andthe switch is electrically coupled to the flex.6. The keystack of claim 5 , wherein the circuitry module further comprises a light source.7. The keystack of claim 6 , wherein:the light source is coupled to a top side of the flex; andthe switch is coupled to a bottom side of the flex.8. The keystack of claim 6 , wherein the circuitry module further comprises a light guide panel for dispersing light provided by the light source underneath a surface of the keycap.9. The keystack of claim 5 , wherein the circuitry module further comprises a sensor configured to detect a touch gesture along a surface of the keycap.10. The keystack of claim 9 , wherein:the sensor is coupled to a top side of the ...

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Номер записи: 51
31-01-2019 дата публикации

EVALUATING AND REDUCING MYOPIAGENIC EFFECTS OF ELECTRONIC DISPLAYS

Номер: US20190035358A1
Автор: Chalberg, Fertik Michael Benjamin Selkowe, JR. Thomas W.
Принадлежит: WaveShift LLC

Techniques for evaluating and reducing myopiagenic effects of electronic displays are disclosed. 1. A method , comprising:{'sub': 1', '2', '1', '2, 'sup': i', 'i', 'i', 'i', 'i', 'i', 'i, 'receiving initial image data for a sequence of frames comprising a first frame, f, and a second frame, f, wherein data for each pixel in fand fcomprises a value, r, for a first color, a value, g, for a second color, and a value, b, for a third color;'}{'sub': '1', 'sup': i', 'i', 'i, "for at least one pixel in f, determining a relative level of stimulation of cones in a viewer's eye based, at least, on the value, r, for the first color and the value, g, for the second color;"}{'sub': 2', '2', '2', '1, 'sup': m', 'i', 'm', 'm', 'm', 'i, "generating modified image data for the sequence of frames comprising a second frame, fcorresponding to the second frame, f, of the initial image data, where fcomprises a value, r, for the first color and a value, g, for the second color for the first pixel based on the level of stimulation of cones in a viewer's eye by the at least one pixel in f; and"}transmitting the modified image data to an electronic display.2. The method of claim 1 , wherein determining a relative level of stimulation of cones comprises determining a relative level of stimulation of neighboring cones in the viewer's eye.3. The method of claim 1 , wherein claim 1 , when viewed on the electronic display claim 1 , fresults in reduced contrast between neighboring cones in a viewer's eye compared to f.4. The method of claim 1 , wherein the second frame occurs after the first frame in the sequence.5. The method of claim 1 , wherein determining the relative level of stimulation comprises comparing the value claim 1 , r claim 1 , for the first color to the value claim 1 , g claim 1 , for the second color.6. The method of claim 5 , wherein ris compared to gfor a plurality of pixels in the first frame of the initial image data.7. The method of claim 5 , wherein claim 5 , for the first ...

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Номер записи: 52
18-02-2016 дата публикации

FABRIC KEYBOARD

Номер: US20160049266A1
Автор: BROCK John M., Corbin Sean S., Coster Daniel J., Cousins Benjamin A., JR. Thomas W., Kuna Melody, Murphy Robert S., Shaffer Benjamin A., Stringer Christopher J., Wilson
Принадлежит:

An input device, such as a keyboard, includes one or more keys that each includes a keycap operable to move within an aperture of a frame to activate a switch and fabric disposed over the frame and keycap. A first region of the fabric is bonded to the keycap and a second region of the fabric is bonded to the frame. The first region may be an embossed region and the second region may be an unembossed region. The fabric may dampen sound from within the keyboard, such as noise related to movement of the keycap, activation of the switch, and so on. The fabric may also form a barrier that restricts passage of contaminants into the aperture and/or other portions of the input device. 1. An input device , comprising:a frame defining an aperture;a keycap within the aperture and operable to move with respect to the frame;a switch positioned under the keycap; and a first region bonded to the keycap; and', 'a second region bonded to the frame., 'a fabric disposed over the frame and keycap, comprising2. The input device of claim 1 , the first region comprising a portion of an embossed structure.3. The input device of claim 2 , the embossed structure comprising:a top section;at least one side section adjacent the top section; whereinthe top section forms at least a portion of the first region.4. The input device of claim 3 , wherein the top section is substantially perpendicular to the at least one side section.5. The input device of claim 3 , the embossed structure further comprising a rounded corner.6. The input device of claim 3 , wherein a height of the embossed structure is defines a travel distance of the keycap.7. The input device of claim 1 , wherein:the keycap comprises a keycap flange; andthe frame comprises a feature that contacts the keycap flange to restrict upward movement of the keycap with respect to the switch.8. The input device of claim 7 , wherein:the keycap further comprises a top surface projecting above the aperture; andthe first region of the fabric is ...

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Номер записи: 53
08-05-2014 дата публикации

VACCINES FOR HSV-2

Номер: US20140127247A1
Автор: Dubensky, Hosken Nancy A., JR. Thomas W., Moore Margaret D., Robbins Scott H.
Принадлежит: IMMUNE DESIGN CORP.

Compositions of recombinant HSV-2 proteins and an agonist of the innate immune system, such as an adjuvant, are provided as a vaccine. Proteins include an envelope glycoprotein and a structural protein other than an envelope glycoprotein, e.g., a capsid or tegument protein. The vaccine is for use in either HSV-2 seropositive or seronegative subjects. 1. An immunogenic , pharmaceutical composition comprising ,(i) an envelope glycoprotein of HSV-2, or an immunological fragment thereof;(ii) a structural protein of HSV-2 other than an envelope glycoprotein of HSV-2, or an immunological fragment thereof;(iii) optionally, an agent that activates innate immunity; and(iv) a pharmaceutically acceptable carrier.2. The composition of wherein the envelope glycoprotein of HSV-2 is gD2.3. (canceled)42. The composition of any of - claims 1 , wherein the structural protein of HSV-2 is selected from the group consisting of UL47 claims 1 , ICP0 claims 1 , UL19 claims 1 , UL25 claims 1 , UL46 claims 1 , UL39 claims 1 , UL7 and UL26.5. The composition of wherein the structural protein of HSV-2 is UL19.6. The composition of wherein the structural protein of HSV-2 is UL19.7. The composition of which comprises an immunological fragment of UL19.8. The composition of which comprises an immunological fragment of UL19 claim 2 , for example claim 2 , SEQ ID NO 12.9. The composition of wherein the structural protein of HSV-2 is UL25.10. The composition of wherein the structural protein of HSV-2 is UL25.11. The composition of which comprises an immunological fragment of UL25.12. The composition of which comprises an immunological fragment of UL25.1316-. (canceled)17. The composition of further comprising a second structural protein of HSV-2 claim 4 , or an immunological fragment thereof.1833-. (canceled)34. The composition of claim 1 , wherein the adjuvant is GLA.35. The composition of comprising gD2; UL25; UL19; GLA adjuvant; and a pharmaceutically acceptable carrier.3645-. (canceled)46. A ...

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Номер записи: 54
26-02-2015 дата публикации

Compositions and methods for activating stimulator of interferon gene-dependent signalling

Номер: US20150056224A1
Автор: David B. Kanne, Edward Emile Lemmens, Laura H. Glickman, Meredith Lai Ling Leong, Russell E. Vance, Thomas W. Dubensky, Jr.
Принадлежит: Aduro Biotech Inc, UNIVERSITY OF CALIFORNIA

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2′,5′,2′,5′ and 2′,5′,3′,5′ CDNs, and preferably Rp,Rp stereosiomers thereof.

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Номер записи: 55
21-02-2019 дата публикации

METHOD AND APPARATUS FOR REDUCING MYOPIAGENIC EFFECT OF ELECTRONIC DISPLAYS

Номер: US20190057673A1
Автор: Chalberg, Fertik Michael Benjamin Selkowe, JR. Thomas W., Olsen David William
Принадлежит:

A method and an apparatus for modifying initial image data for a frame based on a relative level of stimulation of cones in a viewer's eye are disclosed, wherein the modified image data results in reduced contrast between neighboring cones in the viewer's eye. 1. A method , comprising:{'sup': i', 'i', 'i', 'i', 'i, 'receiving, by a processing device, initial image data for a frame fcomprising a plurality of pixels, wherein data for each pixel in the frame fis received sequentially over a respective clock cycle of the processing device and comprises a value, r, for a first color, a value, g, for a second color, and a value, b, for a third color;'}{'sup': m', 'i, 'claim-text': [{'sup': i', 'i, "determining, for each pixel in the subset, a relative level of stimulation of cones in a viewer's eye based, at least, on the value, r, for the first color and the value, g, for the second color; and"}, {'sup': i', 'm', 'm', 'm, "modifying, based, at least, on the determined relative level of stimulation of cones in a viewer's eye by the pixel, the initial image data for the frame f, the modified image data for the frame fcomprising a value, r, for the first color and a value, g, for the second color for the pixel; and"}], 'producing, by the processing device, modified image data for a frame fcorresponding to the frame f, by concurrently performing operations of a sequence of operations on data for a subset of the pixels, wherein a different operation of the sequence is performed per clock cycle on data for a different pixel of the subset, and the operations of the sequence are performed sequentially on data for each pixel over corresponding sequential clock cycles, wherein the operations of the sequence comprise'}{'sup': m', 'm, 'transmitting, by the processing device, the modified image data for the frame fto an electronic display, wherein data for each pixel in the frame fis transmitted sequentially over a respective clock cycle.'}2. The method of claim 1 , wherein{'sup': i ...

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Номер записи: 56
28-02-2019 дата публикации

COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE"-DEPENDENT SIGNALLING

Номер: US20190062365A1
Автор: CANHAM Stephen M., Dubensky, Gauthier Kelsey, Glickman Laura Hix, JR. Thomas W., Kanne David, Katibah George Edwin, Leong Justin, McKenna Jeffrey, McWhirter Sarah M., Ndubaku Chudi Obioma, SUNG Leonard
Принадлежит:

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′- or 3′-mono-fluoro substituted, or 2′3′-di-fluoro substituted mixed linkage 2′,5′-3′,5′ CDNs. 3. The compound according to or , wherein R3 and R4 are independently —OH or —F , provided that at least one of R3 and R4 is —F.6. The compound according to or , wherein R3a and R4a are independently —OH or —F , provided that at least one of R3a and R4a is —F.10. The compound according to any one of - , wherein R3b and R4b are independently —OH or —F , provided that at least one of R3b and R4b is —F.26. A composition comprising one or more compounds according to any one of - and a pharmaceutically acceptable excipient.27. A composition according to claim 26 , wherein the composition does not include an agent that enhances cellular permeability of the one or more compounds or an agent that enhances uptake of the one or more compounds into a cell.28. A composition comprising one or more compounds according to any one of - and a delivery vehicle which enhances cellular uptake and/or stability of the compound.29. The composition according to claim 28 , wherein the delivery vehicle comprises one or more agents selected from the group consisting of lipids claim 28 , liposomes claim 28 , interbilayer crosslinked multilamellar vesicles claim 28 , biodegradable poly(D claim 28 ,L-lactic-co-glycolic acid) [PLGA]-based or poly anhydride-based nanoparticles or microparticles claim 28 , and nanoporous particle-supported lipid bilayers.30. A composition comprising one or more compounds according to any one of - and ...

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Номер записи: 57
08-03-2018 дата публикации

COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE" - DEPENDENT SIGNALLING

Номер: US20180064745A1
Автор: Dubensky, Gauthier Kelsey, Glickman Laura Hix, JR. Thomas W., Kanne David, Katibah George Edwin, Leong Justin, McWhirter Sarah M., SUNG Leonard
Принадлежит: Aduro Biotech, Inc.

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes), In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′-fluoro substituted, bis-3′,5′CDNs, and most preferably one or more 2′,2″-diF-Rp,Rp, bis-3′,5′CDNs. 4. The compound according to claim 3 , wherein R21 and R22 are both adenine.5. The compound according to claim 3 , wherein R21 is adenine and R22 is guanine.8. The compound according to claim 1 , wherein the compound is the sodium claim 1 , potassium claim 1 , calcium claim 1 , magnesium claim 1 , zinc claim 1 , aluminum claim 1 , ammonium claim 1 , diethylamine claim 1 , olamine claim 1 , benzathine claim 1 , benethamine claim 1 , tromethamine (2-amino-2-(hydroxymethyl)propane-1 claim 1 ,3-diol) claim 1 , morpholine claim 1 , epolamine claim 1 , piperidine claim 1 , picoline claim 1 , dicyclohexylamine claim 1 , N claim 1 ,N′-dibenzylethylenediamine claim 1 , 2-hydroxyethylamine claim 1 , tri-(2-hydroxyethyl)amine claim 1 , chloroprocaine claim 1 , choline claim 1 , deanol claim 1 , imidazole claim 1 , diethanolamine claim 1 , ethylenediamine claim 1 , meglumine (N-methylglucamine) claim 1 , procaine claim 1 , dibenzylpiperidine claim 1 , dehydroabietylamine claim 1 , glucamine claim 1 , collidine claim 1 , quinine claim 1 , quinolone claim 1 , erbumine claim 1 , lysine or arginine salt thereof.9. The compound according to claim 1 , wherein the compound is the sodium salt thereof.10. A pharmaceutical composition comprising one or more compounds according to and a pharmaceutically acceptable excipient.11. A pharmaceutical composition comprising one or more compounds according to claim 1 , another ...

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Номер записи: 58
29-05-2014 дата публикации

Carbon Nanotube Transistor Voltage Converter Circuit

Номер: US20140145143A1
Автор: JR. Thomas W., Lim Brian Y., Tombler
Принадлежит: ATOMATE CORPORATION

A voltage converter circuit includes one or more single-walled carbon nanotube transistors, capable of handling relatively high amounts of current. The transistors are formed using a porous structure which has a number of single-walled carbon nanotubes. The porous structure may be anodized aluminum oxide or another porous material. The circuit will be especially suited for power applications, including use in portable electronic devices such as notebook computers, MP3 players, mobile phones, digital cameras, personal digital assistants, and other battery-operated devices. 1. A circuit comprising:a voltage input node;a voltage output node;a first single-walled carbon nanotube transistor coupled between the voltage input node and a first node, wherein the first single-walled carbon nanotube transistor comprises a plurality of single-walled carbon nanotubes between a first gate region and a second gate region;a second single-walled carbon nanotube transistor coupled between the first node and ground; andan inductor coupled between the first node and the voltage output node.2. The circuit of wherein the first and second single-walled carbon nanotube transistors are formed on the same structure.3. The circuit of further comprising:a capacitor between the first node and ground.4. The circuit of further comprising:a resistor between the first node and ground.5. The circuit of wherein the first and second single-walled carbon nanotube transistors do not have bulk node connections.6. The circuit of wherein the first and second gate regions are electrically coupled together.7. The circuit of wherein the first and second gate regions are parallel to each other claim 1 , extending a length A in an X direction and separated by a gap B in a Y direction claim 1 , and the single-walled carbon nanotubes extend in a Z direction claim 1 , perpendicular to both the X and Y directions.8. The circuit of wherein in the gap B claim 7 , there are a plurality of single-walled carbon ...

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Номер записи: 59
16-03-2017 дата публикации

LOW-TRAVEL KEY MECHANISMS USING BUTTERFLY HINGES

Номер: US20170076880A1
Автор: Berg Bruce E., BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Niu James J., Wilson
Принадлежит:

A key mechanism including one or more butterfly hinges. Each butterfly hinge may include a double wing design operative to move between a depressed position and non-depressed position. Hinged coupling mechanisms couple respective arms of the wings together. Additionally or alternatively, a key mechanism can include one or more half-butterfly hinges. Each half-butterfly hinge includes a double wing design operative to move between a depressed position and non-depressed position. A hinged coupling mechanism couples one set of corresponding arms of the wings together, while the other set of corresponding arms are not coupled together. 1. A key mechanism , comprising:a keycap assembly;a support structure;a half-butterfly hinge comprising two separate wings positioned adjacent to each other such that a cavity is formed between the two wings, each wing comprising a major arm and a minor arm shorter than the major arm, each wing comprising a pair of pivot pins coupled to the support structure and a pair of keycap pins coupled to the keycap assembly; anda coupling mechanism coupling the major arms of the half-butterfly hinge together.2. The key mechanism of claim 1 , further comprising a switch secured within the cavity between the keycap assembly and the support structure.3. The key mechanism of claim 2 , wherein the switch comprises an upper conductive deformable structure disposed over a lower conductive deformable structure claim 2 , wherein the switch is closed when the upper conductive deformable structure comes in contact with the lower conductive deformable structure.4. The key mechanism of claim 1 , wherein a first pivot of the pair of pivot pins is coupled to the support structure by a c-clip retaining member and a second pivot of the pair of pivot pins is coupled to the support structure by an L-shaped retaining member.5. The key mechanism of claim 1 , wherein a first pivot of the pair of pivot pins is coupled to the support structure by a c-clip retaining member ...

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Номер записи: 60
15-03-2018 дата публикации

SYSTEMS AND METHODS FOR CONTROLLING ACCESS TO MOBILE DEVICES

Номер: US20180077626A1
Автор: JR. Thomas W., Monsef Eric, Wilson
Принадлежит:

Systems and methods are provided for controlling a user's access to a mobile device in a vehicle. For example, a method includes receiving, at a controlling device, vehicle data related to an operation status of a vehicle. The method includes determine whether the vehicle is in a motion state by comparing the vehicle data to a threshold. When the vehicle data exceeds the threshold, the method includes determining that the vehicle is in the motion state and sending, to a mobile device, a blocking signal in order to prevent a user from using the mobile device for at least one function. When the vehicle data does not exceed the threshold, the method includes determining that the vehicle is not in the motion state and sending, to the mobile device, an accessing signal in order to allow the user to use the mobile device for the at least one function. 1. A method of controlling a user's access to a mobile device in a vehicle , comprising:receiving, at the controlling device from an information unit, vehicle data related to an operation status of a vehicle;connecting a controlling device to a mobile device via a wired connection, wherein the wired connection initially prevents a user from using the mobile device for at least one function independent of the operation status of the vehicle;determining, at the controlling device, whether the vehicle is in a motion state by comparing the vehicle data to a threshold; 'determining, at the controlling device, that the vehicle is in the motion state, and preventing the user from using the mobile device for the at least one function; and', 'when the vehicle data exceeds the threshold determining, at the controlling device, that the vehicle is not in the motion state, and', 'sending, at the controlling device to the mobile device through the wired connection, an accessing signal in order to allow the user to use the mobile device for the at least one function., 'when the vehicle data does not exceed the threshold2. The method of ...

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Номер записи: 61
12-06-2014 дата публикации

Surgical Stapler

Номер: US20140158746A1
Автор: Alesi, Geiste Robert J., JR. Thomas W., Mastri Dominick L., Viola Frank J., Wilson Jon
Принадлежит: COVIDIEN LP

A surgical device is described herein that can be used to fire different types and sizes of disposable loading units. In a preferred embodiment, the device applies parallel rows of surgical fasteners to body tissue and concomitantly forms an incision between the rows of staples during an endoscopic or laparoscopic surgical procedure. The device can be utilized with disposable loading units configured to apply linear rows of staples measuring from about 15 mm in length to about 60 mm in length and can be used to fire disposable loading units containing surgical clips and individual staples. 15-. (canceled)6. A surgical tool for applying staples , comprising:first and second jaws, the first jaw having a plurality of staples arranged in linear rows having a length of about 60 mm, and the second jaw having an anvil, the first and second jaws being pivotably connected and having an open position and a closed position; anda drive member supporting a cam member and a balancing flange at a distal end, the drive member including an elongated drive beam, the drive member being movable through the first and second jaws to eject the staples from the first jaw.7. The surgical tool according to claim 6 , wherein the first jaw includes a longitudinal slot for accommodating the drive member.8. The surgical device according to claim 6 , further comprising a handle assembly including a pivotable handle.9. The surgical device according to claim 8 , wherein multiple movements of the pivotable handle are needed to move the drive member and eject all of the staples from the first jaw.10. The surgical device according to claim 6 , wherein the first jaw includes a surgical stapling cartridge.11. The surgical device according to claim 6 , wherein the drive member includes a knife.12. The surgical device according to claim 6 , wherein the drive member has a distal working head.13. The surgical device according to claim 6 , wherein the drive member includes a vertical strut and a retention ...

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Номер записи: 62
19-03-2020 дата публикации

BUILDING AUTOMATION SYSTEM PROVIDING FOR INTEGRATION OF SUBSYSTEMS

Номер: US20200092126A1
Автор: Anderson, Hennig Andreas, JR. Thomas W., Ramanathan Ganesh
Принадлежит:

There is described a building automation system comprising a control center and an adapter for providing integration of subsystems. The adapter facilitates communications between the control center and a subsystem of the building automation system. A subsystem library of the control center receives an object model associated with the subsystem from the user interface. An extraction tool of the control center generates output information based on the object model. The control center is mapped to the adapter, so that a thing description may be communicated there between. The thing description includes a description of instances hosted by the adapter and representing the object model. An auto discovery component of the control center creates instances of the object model based on the thing description and addresses properties of the object model. The building automation system utilizes the instances and the addresses to manage the subsystem associated with the object model. 1. A building automation system providing for integration of subsystems comprising:a subsystem library of a control center configured to receive an object model associated with a subsystem of the building automation system from a user interface of the control center, wherein the object model includes a plurality of properties associated with the object model;an extraction tool of the control center configured to generate output information based on the object model, wherein the output information includes object-oriented classes and programming types representing the object model; a first system interface of the control center is mapped to a second system interface of the adapter, and', 'a thing description is communicated from the second system interface of the adapter to the first system interface of the control center, the thing description including a description of instances hosted by the adapter and representing the object model; and, 'an adapter configured based on the output information, ...

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Номер записи: 63
12-05-2022 дата публикации

OPHTHALMIC LENSES FOR REDUCING MYOPIC PROGRESSION AND METHODS OF MAKING THE SAME

Номер: US20220146857A1
Автор: Chalberg, Hones, JR. Peter, JR. Thomas W.
Принадлежит:

A method includes providing an ophthalmic lens having a prescribed optical power, the ophthalmic lens having a surface having a base curvature corresponding to the prescribed optical power, and exposing a material at the surface to laser radiation sufficient to locally reshape the material to form a plurality of lenslets on the surface. The lenslets each have a corresponding optical power that differs from the prescribed optical power of the ophthalmic lens. 120-. (canceled)21. A device , comprising:an ophthalmic lens having a prescribed optical power, the ophthalmic lens having a surface having a base curvature corresponding to the prescribed optical power;one or more optical elements formed in or supported by the surface, each optical element providing an optical effect different from the prescribed optical power; andone or more layers of material coated on the surface, each optical element being located at a discontinuity in the one or more layers of material.22. The device of claim 21 , wherein at least some of the optical elements are myopic defocus lenslets.23. The device of claim 21 , wherein at least some of the optical elements are scattering centers.24. The device of claim 21 , wherein the optical elements comprise both myopic defocus lenslets and scattering centers.25. The device of claim 24 , wherein the myopic defocus lenses and scattering centers occupy mutually exclusive areas of the surface.26. The device of claim 24 , wherein at least some of the myopic defocus lenses and scattering centers occupy a common area of the surface.27. The device of claim 21 , wherein the one or more layers of material comprise a hardcoat layer.28. The device of claim 21 , wherein the one or more layers of material comprise an antireflection layer.29. Eyeglasses comprising the device of .30. A method claim 21 , comprising:coating a layer of a first material on a surface of an ophthalmic lens;exposing the layer of the first material to laser radiation sufficient to remove ...

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Номер записи: 64
03-07-2014 дата публикации

SIGNAL PEPTIDE FUSION PARTNERS FACILITATING LISTERIAL EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS OF PREPARATION AND USE THEREOF

Номер: US20140186387A1
Автор: Brockstedt Dirk, Dubensky, Fasso Marcella, Hanson William G., JR. Thomas W., Lauer Peter M., Leong Meredith Lai Ling, Skoble Justin
Принадлежит: Aduro Biotech, Inc.

The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any PEST sequences native to the sequence, and/or for certain hydrophobic residues. 1. A polynucleotide comprising:(a) a promoter; and 'a polypeptide derived by recombinant modification of a secreted Listerial protein sequence, the secreted Listerial protein sequence in its unmodified form comprising a signal sequence and one or more PEST motifs, the modification comprising removal of each of the PEST motifs by deletion or substitution by one or more residues such that the polypeptide lacks any PEST motif; and', '(b) a nucleic acid operably linked to the promoter, wherein the nucleic acid encodes a fusion protein comprisinga non-Listerial antigen.2. The polynucleotide of claim 1 , wherein the secreted Listerial protein sequence is ActA or LLO.3. The polynucleotide of claim 2 , wherein the modification further comprises truncation of the secreted Listerial protein sequence at about residue 100.4. The polynucleotide of claim 1 , wherein the polypeptide retains the signal sequence of the secreted Listerial protein sequence in unmodified form.5. The polynucleotide of claim 1 , wherein the modification further comprises:removal of one or more hydrophobic domains which are not part of the signal sequence of the secreted Listerial protein sequence; and/orsubstitution of one or more residues within one or more hydrophobic domains which are not part of the signal sequence of the secreted Listerial protein ...

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Номер записи: 65
23-04-2015 дата публикации

OPTICAL REGULATION OF GENE EXPRESSION IN THE RETINA

Номер: US20150111275A1
Автор: Chalbert, JR. Thomas W., PALANKER Daniel V.
Принадлежит:

The present invention provides methods and compositions for regulating transgene expression in a subject using heat generated by electro-magnetic radiation in a target cell. The heat is generated by a thermo generator resided in the target cell upon application the electromagnetic radiation. The amount of the heat is controlled by the energy delivered by the electromagnetic radiation. 1. A method for modulating gene expression in a subject , comprising;(a) expressing a transgene in a plurality of cells in a subject, wherein said plurality of cells comprises a target cell, wherein said target cell comprises;(i) a polynucleotide encoding said transgene; and(ii) a thermo generator capable of generating heat upon application of an electromagnetic radiation; and(b) applying said electromagnetic radiation to said target cell to destroy said target cell, thereby modulating expression of said transgene in said subject.2. The method of claim 1 , wherein said target cell is a pigmented cell and said thermo generator comprises a chromophore or pigment.3. The method of claim 2 , wherein said pigmented cell is selected from the group consisting of: retinal pigment epithelium claim 2 , iris epithelium claim 2 , trabecular meshwork epithelium claim 2 , and a cell in the pigmented choroid.410.-. (canceled)11. The method of claim 1 , wherein said electromagnetic radiation is produced by a laser.12. The method of claim 11 , wherein said laser has a beam width of less than 1 mm.13. The method of claim 11 , wherein said laser has a power of about 500 mW to 5 claim 11 ,000 mW.14. The method of claim 1 , wherein said electromagnetic radiation is applied by one or more pulses.15. The method of claim 14 , wherein the duration of said pulse of electromagnetic radiation is less than 100 μs.16. The method of claim 1 , wherein said electromagnetic radiation is applied by scanning a beam of electromagnetic radiation.17. (canceled)18100. The method of claim 16 , wherein the scanning beam has a ...

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Номер записи: 66
07-05-2015 дата публикации

METHODS AND COMPOSITIONS USING LISTERIA FOR ENHANCING IMMUNOGENICITY BY PRIME BOOST

Номер: US20150125485A1
Автор: Bahjat Keith S., Brockstedt Dirk G., Dubensky, JR. Thomas W., Leong Meredith Lai Ling
Принадлежит:

Provided herein are prime-boost regimens and materials used therein. The prime-boost regimens enhance the immune response to a target antigen. The vaccines used for boost are comprised of recombinant attenuated metabolically active that encodes an expressible antigen that is cross-reactive with the target antigen. In some examples, the immune response is a cellular immune response. 149-. (canceled)50. A method for enhancing an immune response in a mammal to mesothelin , comprising:{'i': 'Listeria', 'administering to the mammal an effective amount of a boost dose of a vaccine comprising an attenuated that encodes an expressible, immunologically active portion of mesothelin, wherein the mammal previously had been administered an effective amount of a prime dose of an inactivated tumor cell containing a nucleic acid that encodes granulocyte macrophage-colony stimulation factor (GM-CSF).'}51Listeria. The method of claim 50 , wherein the attenuated comprises a mutation that inactivates ActA claim 50 , InlB claim 50 , or both ActA and InlB.52Listeria. The method of claim 50 , wherein the attenuated is ΔactAΔinlB.53Listeria. The method of claim 50 , wherein the attenuated is killed but metabolically active (“KBMA”). This application claims the priority benefit of U.S. Provisional Application No. 60/831,360, filed Jul. 17, 2006, the contents of which are hereby incorporated by reference herein in their entirety.This invention was made, in part, with U.S. government support under National Cancer Institute NHI 1 K23CA 104160-01. The government may have certain rights in the invention.It is thought to be desirable to establish strong cellular immunity to specific pathogens. Repeated administrations with the same vaccine (homologous boosting) have proven effective for boosting humoral responses. However, this approach is relatively inefficient at boosting cellular immunity because prior immunity to the vector tends to impair robust antigen presentation and the generation of ...

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Номер записи: 67
24-07-2014 дата публикации

COMPOSITIONS COMPRISING CYCLIC PURINE DINUCLEOTIDES HAVING DEFINED STEREOCHEMISTRIES AND METHODS FOR THEIR PREPARATION AND USE

Номер: US20140205653A1
Автор: Dubensky, Glickman Laura Hix, JR. Thomas W., Kanne David B., Lemmens Edward Emile, Leong Meredith Lai Ling
Принадлежит: Aduro Biotech, Inc.

It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers. 1. A composition comprising:one or more cyclic purine dinucleotides or prodrugs or pharmaceutically acceptable salts thereof which induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp diastereomers, or prodrugs or pharmaceutically acceptable salts thereof, wherein said cyclic purine dinucleotides are preferably thiophposphate cyclic purine dinucleotides.2. A composition according to claim 1 , further comprising a pharmaceutically acceptable excipient.3. A composition according to claim 1 , further comprising one or more vaccines selected to stimulate an immune response to one or more predetermined antigens.4. A composition according to claim 3 , wherein the vaccine(s) comprise inactivated or attenuated bacteria or viruses comprising the antigens of interest claim 3 , purified antigens claim 3 , live viral or bacterial delivery vectors recombinantly engineered to express and/or secrete the antigens claim 3 , antigen presenting cell (APC) vectors comprising cells that are loaded with the antigens or transfected with a composition comprising a nucleic acid encoding the antigens claim 3 , liposomal antigen delivery vehicles claim 3 , or naked nucleic acid vectors encoding the antigens.5. A composition according to claim 3 , wherein the vaccine(s) comprise an ...

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Номер записи: 68
14-05-2015 дата публикации

FEEDBACK SYSTEMS FOR INPUT DEVICES

Номер: US20150130730A1
Автор: Augenbergs Peteris K., Harley Jonah A., JR. Thomas W., KESSLER Patrick, Patel Dhaval Chandrakant, Staton Kenneth L., Wilson
Принадлежит:

An electronic device including a processor, a display screen in communication with the processor, a track pad in communication with the processor including a movable surface that is selectively movable in at least one direction to provide feedback to a user, and a feedback system in communication with the processor including a feedback sensor. The feedback sensor determines a movement characteristic of the movable surface and the processor selectively adjusts at least one setting of the track pad based on the movement characteristic. 1. A method for calibrating a haptic output device for electronic device comprising:sensing by at least one feedback sensor a movement characteristic of a movable surface of the haptic output device;determining by a processor whether the at least one movement characteristic is accurate; andif the at least one movement characteristic is not accurate, adjusting at least one characteristic of the haptic output device.2. The method of claim 1 , wherein the haptic output device is a track pad.3. The method of claim 1 , wherein adjusting at least one characteristic of the haptic output device comprises varying an input waveform of an actuator operably connected to the movable surface and configured to selectively move the movable surface.4. The method of claim 3 , wherein varying the input waveform of the actuator comprises adjusting at least one of a magnitude claim 3 , duration claim 3 , or shape of the input waveform.5. The method of claim 1 , wherein the at least one feedback sensor is an accelerometer claim 1 , and the at least one feedback sensor is operably connected to the movable surface and configured to detect an acceleration of the movable surface.6. The method of claim 1 , wherein the at least one feedback sensor is an optical distance sensor.7. The method of claim 1 , wherein the at least one feedback sensor comprises a first feedback sensor and a second feedback sensor.8. The method of claim 1 , wherein the at least one sensor ...

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Номер записи: 69
10-05-2018 дата публикации

TREATMENT OF OCULAR NEOVASCULARIZATION USING ANTI-VEGF PROTEINS

Номер: US20180125948A1
Автор: Chalberg, Constable Ian J., JR. Thomas W., Lai Chooi-May, Rakoczy P. Elizabeth
Принадлежит:

The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by administering subretinally a pharmaceutical composition comprising a pharmaceutically effective amount of a vector comprising a nucleic acid encoding soluble Fms-related tyrosine kinase-1 (sFlt-1) protein to the human subject. 1. A method for the treatment of ocular neovascularization in an eye of a human subject suffering from ocular neovascularization , said eye of the human subject having previously received a first intravitreal injection of an anti-Vascular Endothelial Growth Factor (VEGF) agent in an amount such that the anti-VEGF agent is present in the eye of the subject at a concentration sufficient to prevent progression of the neovascularization at the time of application of the method , the method comprising:{'sup': 6', '15, 'administering to the eye of the human subject a single dose of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant virus comprising a nucleic acid sequence encoding an anti-VEGF protein, wherein the single dose comprises at least 1×10and at most 1×10vector genomes of the recombinant virus, and is sufficient to cause elevated levels of said anti-VEGF protein in the eye of said human subject when measured at least one year after the administration of the pharmaceutical composition;'}wherein the eye of the subject does not require rescue treatment with an anti-VEGF agent to arrest or reverse progression of the ocular neovascularization during the period between about 180 days and about one year following the administration of the pharmaceutical composition.2. The method of wherein the recombinant virus is a recombinant adeno-associated virus (rAAV).3. The method of claim 2 , wherein the rAAV is selected from the group consisting of: AAV1 claim 2 , AAV2 claim 2 , AAV2.5 AAV3 claim 2 , AAV4 claim 2 , AAV5 claim 2 , AAV6 claim 2 , AAV7 claim 2 ...

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Номер записи: 70
21-05-2015 дата публикации

Portable Computer Display Structures

Номер: US20150138710A1
Автор: Augenbergs Peteris K., Degner Brett W., JR. Thomas W., Ligtenberg Chris, Mathew Dinesh C., Posner Bryan W., Wilson, Yin Victor H.
Принадлежит:

An electronic device housing may have upper and lower portions that are attached with a hinge. At least one portion of the housing may have a rear planar surface and peripheral sidewalls having edges. A display module may be mounted in the housing. The display module may have glass layers such as a color filter glass layer and a thin-film transistor substrate. The color filter glass layer may serve as the outermost glass layer in the display module. The edges of the display module may be aligned with the edges of the peripheral housing sidewalls to create the appearance of a borderless display for the electronic device. The display module may be provided with an opening that allows a camera or other electronic components to receive light. Traces may be provided on the underside of the thin-film transistor substrate to serve as signal paths for the electrical components. 120-. (canceled)21. A portable electronic device , comprising:a display;a housing including a shelf that supports the display; anda pliant interface positioned between the shelf and the display that couples the display to the housing.22. The portable electronic device of claim 21 , wherein the pliant interface comprises a gasket.23. The portable electronic device of claim 21 , wherein the pliant interface comprises an elastomeric material.24. The portable electronic device of claim 21 , wherein the pliant interface compresses in response to exertion of force upon the display.25. The portable electronic device of claim 21 , wherein the display comprises a cover coupled to a polarizer layer.26. The portable electronic device of claim 25 , wherein the cover comprises glass.27. The portable electronic device of claim 21 , wherein the pliant interface protects the display from the housing.28. The portable electronic device of claim 21 , wherein the pliant interface is positioned under the display.29. The portable electronic device of claim 21 , wherein the pliant interface comprises a compressible ...

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Номер записи: 71
03-06-2021 дата публикации

OPHTHALMIC LENSES WITH LIGHT SCATTERING FOR TREATING MYOPIA

Номер: US20210165244A1
Автор: Chalberg, HONES Peter, JR. Thomas W.
Принадлежит:

An ophthalmic lens that includes a lens material having two opposing curved surfaces, the curved surfaces defining a lens axis; and a light scattering region surrounding a clear aperture. The clear aperture and the light scattering region are substantially centered on the lens axis, and the light scattering region has a plurality of spaced apart scattering centers (e.g., on a lens surface and/or embedded in the lens material) sized and shaped to scatter incident light, the scattering centers being arranged in a pattern that includes a random variation in spacing between adjacent dots and/or a random variation in dot size. 1. (canceled)2. A method , comprising:forming, on an ophthalmic lens, a plurality of spaced apart scattering centers sized and shaped to scatter light incident on the ophthalmic lens,wherein the scattering centers are formed in a pattern such that each scattering center is the located at or near a corresponding array site of a two-dimensional array in which the spacing between array sites is a first distance, Dx, in one direction in a plane of the array and a second distance, Dy, in a second direction in the plane of the array, the second direction being orthogonal to the first direction, [{'br': None, 'i': 'x=Ax·Dx·RN', 'δ[0,1], and'}, {'br': None, 'i': 'y=Ay·Dy·RN', 'δ[0,1],'}], 'wherein a center of each scattering center is displaced from a corresponding array site by an amount δx in the first direction and by an amount δy in the second direction, where'}wherein Ax and Ay are amplitudes that are between 0 and 1 and RN is a random number between 0 and 1.3. The method of claim 2 , wherein the scattering centers are formed on a surface of the ophthalmic lens.4. The method of claim 2 , wherein the scattering centers are formed in a bulk of the ophthalmic lens.5. The method of claim 2 , wherein forming the scattering centers comprises exposing the ophthalmic lens to laser radiation.6. The method of claim 2 , wherein forming the scattering centers ...

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Номер записи: 72
25-05-2017 дата публикации

Methods for Fabricating Display Structures

Номер: US20170147036A1
Автор: Augenbergs Peteris K., Degner Brett W., Hotelling Steve, JR. Thomas W., Ligtenberg Chris, Mathew Dinesh C., Posner Bryan W., Sung Kuo-Hua, Wilson, Yin Victor H., Youngs Lynn, Zhong John Z.
Принадлежит:

An electronic device display may have a color filter layer and a thin film transistor layer. A layer of liquid crystal material may be interposed between the color filter layer and the thin film transistor layer. A layer of polarizer may be laminated onto the surface of the color filter layer. Laser trimming may ensure that the edges of the polarizer are even with the edges of the color filter layer. The thin film transistor layer may have an array of thin film transistors that control pixels of the liquid crystal material in the display. Driver circuitry may be used to control the array. The driver circuitry may be encapsulated in a planarized encapsulant on the thin film transistor layer or may be mounted to the underside of the color filter layer. Conductive structures may connect driver circuitry on the color filter layer to the thin film transistor layer. 1. A display having an active area surrounded by an inactive area , the display comprising:a color filter layer and a thin-film transistor layer that form an array of display pixels in the active area;a layer of opaque masking material that forms an opaque border in the inactive area; anda display driver integrated circuit that controls the array of display pixels mounted on the color filter layer, wherein the layer of opaque masking material overlaps the display driver integrated circuit.2. The display defined in claim 1 , further comprising:a polarizer layer having an opening in the inactive area.3. The display defined in claim 2 , wherein the layer of opaque masking material comprises an opening that is aligned with the opening in the polarizer layer.4. The display defined in claim 3 , wherein the color filter layer comprises a substrate having first and second opposing surfaces claim 3 , wherein the polarizer is formed on the first surface claim 3 , and wherein the layer of opaque masking material is formed on the second surface.5. The display defined in claim 4 , further comprising conductive traces ...

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Номер записи: 73
07-05-2020 дата публикации

Adjustable Keyboard

Номер: US20200142502A1
Автор: JR. Thomas W., Wilson
Принадлежит:

The present invention extends adjustable keyboard components. A user can selectively adjust height, tilt, and other keyboard positioning aspects (e.g., pitch, tilt, roll, yaw etc.), to accommodate the specific preferences and/or physical or anatomical characteristics of the user. Keyboard adjustments can tailor a solid foundational position for the user's fingers and hands. The keyboard can include separate left and right modules. Adjustability and separability facilitate highly variable and independent movement of the user's left and right hands. Adjustments and re-adjustments allow a user to make a wide range of alterations to their typing position at any point in time based on circumstances and comfort. As such, adjustments and re-adjustments can (potentially significantly) reduce discomfort and/or injuries associated with repetitive motion. 1. An apparatus comprising:a container containing media and including a ball and socket joint;a top plate attached to the container and configured to couple to a matched keyboard module;a bottom plate attached to the container;one or more feet secured to the bottom plate;wherein the ball and socket joint is configured to pivot in response to sufficient pressure applied to the top plate to change the orientation of the top plate relative to the orientation of bottom plate.2. The apparatus of claim 1 , wherein the container comprising a container constructed from one or more of: fabric claim 1 , plastic claim 1 , or vinyl.3. The apparatus of claim 1 , wherein the container containing media comprises a container containing one or more of: PVC pellets claim 1 , expanded polystyrene beads claim 1 , or expanded polypropylene beads.4. The apparatus of claim 1 , further comprising a 3D shaped keyboard attached to the top plate claim 1 , the 3D shaped keyboard including one or more keys; andwherein the media provides sufficient structure to maintain the changed orientation against the force a keyboard key being depressed.5. The ...

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Номер записи: 74
07-05-2020 дата публикации

METHODS AND SYSTEMS FOR EVALUATING AND REDUCING MYOPIC POTENTIAL OF DISPLAYED COLOR IMAGES

Номер: US20200143536A1
Автор: Chalberg, JR. Thomas W., Kuchenbecker James, Neitz Jay
Принадлежит:

Evaluating differential stimulation of L and M cones in a viewer's eye by an image displayed on a color display includes receiving information about the spectral emission properties of the display; receiving image data; determining an achromatic component of the image based on image data and information about the spectral emission properties of the display, the achromatic component representing differential stimulation of L and M cones due to contrast variations in the image; determining a chromatic component of the image based image data and information about the spectral emission properties of the color display, this component representing differential stimulation of L and M cones due to spectral content of the image; and evaluating the differential stimulation of L and M cones based on the chromatic and achromatic components. 1. A method for evaluating differential stimulation of L and M cones in a viewer's eye by an image displayed on a color display , the method comprising:receiving information about the spectral emission properties of the color display;receiving image data about the image;determining an achromatic component of the image based on one or more pixels of the image and the information about the spectral emission properties of the color display, the achromatic component representing differential stimulation of L and M cones due to contrast variations in the image;determining a chromatic component of the image based on one or more pixels of the image and the information about the spectral emission properties of the color display, the chromatic component representing differential stimulation of L and M cones due to a spectral content of the image; andevaluating the differential stimulation of L and M cones in the viewer's eye by the image displayed on the color display based on the chromatic and achromatic components.2. The method of claim 1 , further comprising adjusting a color setting of the color display and displaying the image on the color ...

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Номер записи: 75
16-06-2016 дата публикации

Water Dispersible Phase Change Ink Suitable For Use As A Photo-Mask

Номер: US20160168403A1
Автор: Bo Wu, Jule W. Thomas, Jr.
Принадлежит: Xerox Corp

A water dispersible phase change ink composition including a hydrophilic wax having at least one ethoxyl moiety; a low viscosity wax having at least one hydroxyl group, wherein the low viscosity wax is miscible with the hydrophilic wax; an optional stabilizer; and a colorant, wherein the colorant is selected to absorb light in a region that one wants to block. An ink jet printer stick or pellet comprising the water dispersible phase change ink composition. A process for forming a photo-imaged stencil using the water dispersible phase change ink composition.

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Номер записи: 76
23-06-2016 дата публикации

METHODS AND COMPOSITIONS USING LISTERIA FOR ENHANCING IMMUNOGENICITY BY PRIME BOOST

Номер: US20160175415A1
Автор: Bahjat Keith S., Brockstedt Dirk G., Dubensky, JR. Thomas W., Leong Meredith Lai Ling
Принадлежит:

Provided herein are prime-boost regimens and materials used therein. The prime-boost regimens enhance the immune response to a target antigen. The vaccines used for boost are comprised of recombinant attenuated metabolically active that encodes an expressible antigen that is cross-reactive with the target antigen. In some examples, the immune response is a cellular immune response. 50. A method for enhancing an immune response in a mammal to a cancerous cell present within the mammal , comprising:{'i': Listeria', 'Listeria, 'administering to the mammal an effective amount of a boost dose of a vaccine comprising an attenuated that encodes an expressible, immunologically active portion of a target antigen expressed by the cancerous cell that is heterologous to the attenuated , wherein the mammal previously had been administered an effective amount of a prime dose of an inactivated tumor cell vaccine expressing a nucleic acid that encodes granulocyte macrophage-colony stimulation factor (GM-CSF).'}51. The method of claim 50 , wherein the inactivated tumor cell vaccine comprises inactivated autologous tumor cells.52. The method of claim 50 , wherein the inactivated tumor cell vaccine comprises inactivated allogeneic tumor cells.53. The method of claim 50 , wherein the cancerous cell is an adenocarcinoma cell.54. The method of claim 51 , wherein the cancerous cell is an adenocarcinoma cell.55. The method of claim 52 , wherein the cancerous cell is an adenocarcinoma cell.56Listeria. The method of claim 50 , wherein the attenuated comprises a mutation that inactivates ActA claim 50 , InlB claim 50 , or both ActA and InlB.57Listeria. The method of claim 51 , wherein the attenuated is ΔactAΔinlB.58Listeria. The method of claim 50 , wherein the attenuated is killed but metabolically active (“KBMA”).59. The method of claim 50 , wherein the target antigen is Annexin II. This application claims the priority benefit of U.S. Provisional Application No. 60/831,360, filed Jul. 17, ...

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Номер записи: 77
25-06-2015 дата публикации

Elastomeric shear Material Providing Haptic Response Control

Номер: US20150177899A1
Автор: Augenbergs Peteris K., BROCK John M., Degner Brett W., Harley Jonah A., JR. Thomas W., KESSLER Patrick, LIGTENBERG Christiaan A., Wilson
Принадлежит:

A haptic response element is contemplated. The haptic response element may generate a tactile feeling as an output and is associated with a computing device. The tactile feeling may be created by moving a part of the haptic response element. A gel may act to return the moving part of the haptic response element to a starting or zero point. Motion of the moving part may exert a shear force on the gel, rather than a compressive force. 1. An apparatus , comprising:a moving part;a stable part;a gel linking the moving part and the stable part, the gel configured to experience a shear force when the moving part moves; anda force sensor affixed to the stable part and operative to sense a force exerted on the moving part; whereinthe gel is configured to provide a first shear stiffness along a first axis and a second shear stiffness along a second axis, the first and second shear stiffnesses being different from one another.23-. (canceled)4. The apparatus of claim 1 , further comprising an actuator coupled to the stable part claim 1 , the actuator configured to displace the moving part in response to an actuation signal.5. The apparatus of claim 4 , wherein the gel returns the moving part to a neutral position when the actuation signal ceases.6. The apparatus of claim 5 , wherein the gel functions to damp a return motion of the moving part.7. The apparatus of claim 6 , wherein the gel is striction-free.8. The apparatus of claim 4 , wherein the actuator is an electromagnetic actuator.9. The apparatus of claim 1 , wherein the gel comprises:a first surface; anda second surface opposing the first surface, the second surface at least partially discontinuous, thereby reducing a shear stiffness of the gel in a direction.10. The apparatus of claim 9 , wherein the at least partially discontinuous surface comprises one of a slice claim 9 , a score claim 9 , or a perforation.11. The apparatus of claim 1 , taking the form of a trackpad.12. The apparatus of claim 1 , taking the form of a ...

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Номер записи: 78
18-09-2014 дата публикации

Protective Helmet

Номер: US20140259313A1
Автор: JR. Thomas W., Sullivan Janet Alan, Swarbrick
Принадлежит:

A helmet includes five layers; and outer shell, an intermediate foam component, a multi-cell bladder component filled with Ringer's Solution, a suspension rig, and a membrane component filed with a settable composition to conform to the wearer's head. 1. A helmet comprising:an outer shell sized and configured to surround and protect the head of a wearer;an intermediate component formed of a light weight foam material, the intermediate component being substantially co-extensive with and affixed to the outer shell;a bladder component affixed to the intermediate component, the bladder component filled with Ringer's Solution;a suspension rig engaged within the bladder component, the rig being sized and configured to be substantially co-extensive with the bladder component to provide support for therefore; anda membrane component supported by the suspension rig, the membrane component configured to contact the head of the wearer.2. The helmet of claim 1 , wherein the membrane component includes a settable composition that is configured to conform the membrane component to the wearer's head prior to setting.3. The helmet of claim 2 , wherein the membrane component includes a fill valve configured to engage a device for injecting the settable composition into the membrane component.4. The helmet of claim 1 , wherein the membrane component is removably engaged to the suspension rig.5. The helmet of claim 4 , wherein the membrane component is removably engaged to the suspension rig by hook-and-loop fasteners.64. The helmet of claim 1 , wherein the bladder component is a multi-cell bladder claim 1 , each cell being filled with Ringer's Solution.7. The helmet of claim 1 , wherein the membrane component is not co-extensive with the outer shell.8. The helmet of claim 1 , wherein the suspension rig is configured to support a face guard.9. The helmet of claim 1 , wherein the outer shell is formed of a reaction injection molded polyurethane.10. The helmet of claim 9 , wherein the ...

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Номер записи: 79
09-07-2015 дата публикации

MOVABLE TRACK PAD WITH ADDED FUNCTIONALITY

Номер: US20150193038A1
Автор: Andre Bartley K., CASEBOLT Matthew P., DEGNER Brett William, JR. Thomas W., KESSLER Patrick, LIGTENBERG Christiaan A., Wilson
Принадлежит:

An input device is disclosed. The input device includes a movable touch-sensitive track pad capable of detecting an object in close proximity thereto so as to generate a tracking control signal. The input device also includes a movement indicator capable of detecting the movements of the movable track pad so as to generate one or more other control signals (e.g., button signals). The control signals can be used to perform actions in an electronic device operatively coupled to the input device. 1. (canceled)2. An input device comprising:a frame;an input surface positioned within the frame and configured to detect a user touch and a location of the user touch on the input surface;a movement indicator coupled to the input surface configured to detect a depression of the input surface along an axis in response to a user touch; andan adjustable limiter coupled to the frame defining a selected distance of depression required for the movement indicator to detect the depression.3. The input device of claim 2 , wherein the input surface comprises a multi-touch input surface.4. The input device of claim 2 , wherein the movement indicator comprises a switch.5. The input device of claim 4 , wherein the adjustable limiter comprises a set screw positioned below the dome switch.6. The input device of claim 2 , further comprising a shoulder portion coupled to the frame configured to maintain a substantially flush relationship between the input surface and an external surface of a housing coupled to the frame in the absence of a depression of the input surface.7. The input device of claim 2 , wherein:the input surface is configured to send a first signal to an electronic device of the location of the user touch; andthe movement indicator is configured to send a second signal to the electronic device upon a detected depression.8. The input device of claim 2 , wherein the first and second signals are sent substantially simultaneously.9. The input device of claim 2 , wherein the ...

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Номер записи: 80
13-06-2019 дата публикации

Methods for Fabricating Display Structures

Номер: US20190179367A1
Автор: Augenbergs Peteris K., Degner Brett W., Hotelling Steve, JR. Thomas W., Ligtenberg Chris, Mathew Dinesh C., Posner Bryan W., Sung Kuo-Hua, Wilson, Yin Victor H., Youngs Lynn, Zhong John Z.
Принадлежит:

An electronic device display may have a color filter layer and a thin film transistor layer. A layer of liquid crystal material may be interposed between the color filter layer and the thin film transistor layer. A layer of polarizer may be laminated onto the surface of the color filter layer. Laser trimming may ensure that the edges of the polarizer are even with the edges of the color filter layer. The thin film transistor layer may have an array of thin film transistors that control pixels of the liquid crystal material in the display. Driver circuitry may be used to control the array. The driver circuitry may be encapsulated in a planarized encapsulant on the thin film transistor layer or may be mounted to the underside of the color filter layer. Conductive structures may connect driver circuitry on the color filter layer to the thin film transistor layer. 1. An electronic device comprising:a housing: a color filter layer,', 'driver circuitry comprising at least an integrated circuit mounted on the color filter layer,', 'a thin-film transistor layer, and', 'an opaque layer formed in a border around a periphery of the display that blocks inactive peripheral portions of the display from view, wherein the opaque layer has an opening; and, 'a display mounted in the housing, wherein the display comprisesa light-sensitive component in the housing that receives light through the opening in the opaque layer.2. The electronic device defined in wherein the light-sensitive component is a camera.3. The electronic device defined in wherein the display further comprises a polarizer layer having an opening that is aligned with the opening in the opaque layer and wherein the camera receives light through the opening in the opaque layer and the opening in the polarizer layer.4. The electronic device defined in wherein the color filter layer comprises a substrate having first and second opposing surfaces claim 3 , wherein the polarizer layer is formed on the first surface claim 3 ...

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Номер записи: 81
15-07-2021 дата публикации

Active Agent Delivery Devices and Methods for Using the Same

Номер: US20210213203A1
Автор: Chalberg, JR. Thomas W., Smith Stephen J.
Принадлежит:

Therapeutic agent delivery devices are provided. Aspects of the devices include a syringe that is not surface sterilized, a tip that includes a sterile tissue contacting surface and a needle operably coupled to the syringe and the tip. Also provided are methods of using the devices. 1. An active agent delivery device , the device comprising:(a) a syringe that is not surface sterilized and comprises a liquid composition of the active agent;(b) a tip comprising a sterile tissue contacting surface; and(c) a needle operably coupled to the syringe and the tip.2. The device according to claim 1 , wherein the syringe has a volume ranging from 0.1 to 5.0 ml.3. The device according to any of the preceding claims claim 1 , wherein the device is configured to deliver a dosage having a volume ranging from 5 μl to 100 μl.4. The device according to any of the preceding claims claim 1 , wherein the syringe comprises a dosing mark.5. The device according to any of the preceding claims claim 1 , wherein the sterile tissue contacting surface comprises a passageway dimensioned to accommodate passage of the needle therethrough.6. The device according to any of the preceding claims claim 1 , wherein the distal end of the needle is movable relative to the sterile tissue contacting surface.7. The device according to any of the preceding claims claim 1 , wherein the needle is present in a needle housing.8. The device according to claim 7 , wherein the tip is operably coupled to the distal end of the needle housing and the distal end of the syringe is operably coupled to the proximal end of the needle housing.9. The device according to any of the preceding claims claim 7 , wherein the device further comprises an actuator component comprising an actuator configured to move the liquid composition through the needle.10. The device according to claim 9 , wherein the actuator component further comprises a pain mitigation system operatively coupled to the tip.11. A tip component for an active ...

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Номер записи: 82
13-06-2019 дата публикации

LOW-TRAVEL KEY MECHANISMS USING BUTTERFLY HINGES

Номер: US20190180955A1
Автор: Berg Bruce E., BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Niu James J., Wilson
Принадлежит:

A key mechanism including one or more butterfly hinges. Each butterfly hinge may include a double wing design operative to move between a depressed position and non-depressed position. Hinged coupling mechanisms couple respective arms of the wings together. Additionally or alternatively, a key mechanism can include one or more half-butterfly hinges. Each half-butterfly hinge includes a double wing design operative to move between a depressed position and non-depressed position. A hinged coupling mechanism couples one set of corresponding arms of the wings together, while the other set of corresponding arms are not coupled together. 1. A key mechanism , comprising:a keycap assembly;a support structure; and a first wing having a first gear member, the first gear member comprising a first upper tooth and a first lower tooth;', 'a second wing having a second gear member, the second gear member comprising a second upper tooth and a second lower tooth;', 'wherein the first upper tooth of the first gear member engages the second lower tooth of the second gear member and the first lower tooth of the first gear member engages the second upper tooth of the second gear member to pivotally couple the first wing to the second wing;', 'a first and second pair of pivot pins coupled to the support structure; and', 'a first and second pair of keycap pins coupled to the keycap assembly., 'a butterfly hinge comprising2. The key mechanism of claim 1 , wherein:the first wing includes a third gear member, the third gear member comprising a third upper tooth and a third lower tooth; andthe second wing including a fourth gear member, the fourth gear member comprising a fourth upper tooth and a fourth lower tooth;wherein the third upper tooth engages the fourth lower tooth and the third lower tooth engages the fourth upper tooth to pivotally couple the first wing to the second wing.3. The key mechanism of claim 1 , wherein the first and second wings are positioned adjacent to each other to ...

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Номер записи: 83
11-06-2020 дата публикации

COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE" - DEPENDENT SIGNALLING

Номер: US20200179431A1
Автор: Dubensky, Gauthier Kelsey, Glickman Laura Hix, JR. Thomas W., Kanne David, Katibah George Edwin, Leong Justin, McWhirter Sarah M., SUNG Leonard
Принадлежит: Aduro Biotech, Inc.

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′-fluoro substituted, bis-3′,5′ CDNs, and most preferably one or more 2′,2″-diF-Rp,Rp, bis-3′,5′CDNs. 1. (canceled)2. (canceled)4. The compound according to claim 3 , wherein R21 and R22 are both adenine.5. The compound according to claim 3 , wherein R21 is adenine and R22 is guanine.6. (canceled)7. (canceled)8. The compound according to claim 3 , wherein the compound is the sodium claim 3 , potassium claim 3 , calcium claim 3 , magnesium claim 3 , zinc claim 3 , aluminum claim 3 , ammonium claim 3 , diethylamine claim 3 , olamine claim 3 , benzathine claim 3 , benethamine claim 3 , tromethamine (2-amino-2-(hydroxymethyl)propane-1 claim 3 ,3-diol) claim 3 , morpholine claim 3 , epolamine claim 3 , piperidine claim 3 , picoline claim 3 , dicyclohexylamine claim 3 , N claim 3 ,N′-dibenzylethylenediamine claim 3 , 2-hydroxyethylamine claim 3 , tri-(2-hydroxyethyl)amine claim 3 , chloroprocaine claim 3 , choline claim 3 , deanol claim 3 , imidazole claim 3 , diethanolamine claim 3 , ethylenediamine claim 3 , meglumine (N-methylglucamine) claim 3 , procaine claim 3 , dibenzylpiperidine claim 3 , dehydroabietylamine claim 3 , glucamine claim 3 , collidine claim 3 , quinine claim 3 , quinolone claim 3 , erbumine claim 3 , lysine or arginine salt thereof.9. The compound according to claim 3 , wherein the compound is the sodium salt thereof.10. A pharmaceutical composition comprising one or more compounds according to and a pharmaceutically acceptable excipient.11. A pharmaceutical composition comprising ...

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Номер записи: 84
22-07-2021 дата публикации

Portable Computer Display Structures

Номер: US20210223822A1
Автор: Augenbergs Peteris K., Degner Brett W., JR. Thomas W., Ligtenberg Chris, Mathew Dinesh C., Posner Bryan W., Wilson, Yin Victor H.
Принадлежит:

An electronic device housing may have upper and lower portions that are attached with a hinge. At least one portion of the housing may have a rear planar surface and peripheral sidewalls having edges. A display module may be mounted in the housing. The display module may have glass layers such as a color filter glass layer and a thin-film transistor substrate. The color filter glass layer may serve as the outermost glass layer in the display module. The edges of the display module may be aligned with the edges of the peripheral housing sidewalls to create the appearance of a borderless display for the electronic device. The display module may be provided with an opening that allows a camera or other electronic components to receive light. Traces may be provided on the underside of the thin-film transistor substrate to serve as signal paths for the electrical components. 1. An electronic device comprising: a layer having a first opening,', 'a transparent layer that overlaps the layer, and', 'a coating on the transparent layer, wherein the coating defines a second opening and at least a portion of the second opening overlaps the first opening; and, 'a display comprisinga light-sensing component overlapped by the transparent layer, wherein the light-sensing component receives light through the transparent layer, the first opening, and the second opening.2. The electronic device defined in wherein the display is a liquid crystal display.3. The electronic device defined in wherein the layer having the first opening is a color filter layer.4. The electronic device defined in further comprising:a thin-film transistor layer having a third opening through which the light-sensing component at least partially extends.5. The electronic device defined in wherein the light-sensing component is a camera.6. The electronic device defined in wherein the display has an active area surrounded by an inactive area claim 5 , and the first and second openings are formed in the inactive ...

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Номер записи: 85
12-07-2018 дата публикации

LOW-TRAVEL KEY MECHANISMS USING BUTTERFLY HINGES

Номер: US20180197696A1
Автор: Berg Bruce E., BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Niu James J., Wilson
Принадлежит:

A key mechanism including one or more butterfly hinges. Each butterfly hinge may include a double wing design operative to move between a depressed position and non-depressed position. Hinged coupling mechanisms couple respective arms of the wings together. Additionally or alternatively, a key mechanism can include one or more half-butterfly hinges. Each half-butterfly hinge includes a double wing design operative to move between a depressed position and non-depressed position. A hinged coupling mechanism couples one set of corresponding arms of the wings together, while the other set of corresponding arms are not coupled together. 120-. (canceled)21. A key mechanism , comprising:a keycap assembly comprising:a keycap;an electronic component coupled to the keycap and comprising a flexible printed circuit; anda clip;a support structure below the keycap assembly and comprising a pin retention member extending towards the keycap;a support mechanism configured to allow the keycap assembly to move relative to the support structure and comprising:a first pin engaged with the clip to retain the support mechanism to the keycap assembly; anda second pin engaged with the pin retention member to retain the support mechanism to the support structure; anda dome switch between the keycap and the support structure and configured to collapse in response to actuation of the keycap assembly.22. The key mechanism of claim 21 , wherein:the keycap assembly further comprises a substructure; andthe clip is secured to the substructure.23. The key mechanism of claim 22 , wherein the first pin is rotatably engaged with the clip.24. The key mechanism of claim 22 , wherein the substructure further comprises a pin retaining mechanism operative to slidably engage a third pin of the support structure.25. The key mechanism of claim 22 , wherein the substructure is coupled to the keycap.26. The key mechanism of claim 22 , wherein the substructure is coupled to the electronic component.27. The key ...

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Номер записи: 86
27-06-2019 дата публикации

MULTI-FUNCTIONAL KEYBOARD ASSEMBLIES

Номер: US20190196603A1
Автор: Andre Bartley K., BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Mathew Dinesh C., Niu James J., SILVANTO Mikael, Wilson
Принадлежит:

Multi-functional keyboard assemblies include an array of keys formed from stacked component layers. A top portion of the key may be capable of travelling vertically with respect to a base of the key. The top portion can include a keycap and a circuitry module coupled to the keycap. The keys may be capable of receive at least two distinct types of inputs and/or receiving at least one type of input and providing at least one type of output. Such output may include use of one or more light sources, displays, and/or haptic feedback devices. 1. A keyboard , comprising:a base;a keycap;a support mechanism coupled to the base and coupled to the keycap;a switch positioned between the keycap and the base, the switch being compressible in response to movement of the keycap relative to the base; anda flexible membrane positioned between the switch and the keycap, the flexible membrane being coupled to the keycap, the flexible membrane comprising a conductive material configured to route electrical signals through the flexible membrane.2. The keyboard of claim 1 , further comprising:a processor in electrical communication with the conductive material; anda flexible tail positioned electrically between the flexible membrane and the processor;wherein the flexible membrane is compressible to close a circuit and transfer a signal to the processor.3. The keyboard of claim 1 , wherein the flexible membrane is bendable in response to movement of the keycap relative to the base.4. The keyboard of claim 1 , wherein the switch is closable to indicate a change in position of the keycap relative to the base.5. The keyboard of claim 1 , wherein the switch is closable to complete a circuit claim 1 , the circuit including the conductive material of the flexible membrane.6. The keyboard of claim 1 , wherein the flexible membrane comprises a tail extending toward the base.7. The keyboard of claim 6 , wherein the tail electrically connects the flexible membrane to the base.8. The keyboard of ...

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Номер записи: 87
20-07-2017 дата публикации

METHODS FOR DISPLAYING AN E-BOOK USING A COMBINATION OF COLORS FOR TEXT AND BACKGROUND THAT HAVE A REDUCED MYOPIAGENIC EFFECT

Номер: US20170205977A1
Автор: Chalberg, Fertik Michael Benjamin Selkowe, JR. Thomas W.
Принадлежит:

Methods for displaying an e-book using a combination of colors for text and background that have a reduced myopiagenic effect compared to black text on white background, include: presenting a user with one or more combinations of colors for the text and background identified as having a reduced myopiagenic effect, wherein none of the presented combinations comprise either black or white text or either black or white background, and, when viewed by the user's retina, an image composed of text and background rendered in any of the presented color combinations provides reduced center-surround contrast on the user's retina compared to the image viewed as black text on white background; receiving a selection of one of the color combinations from the user; and displaying the e-book file using the combination of colors for the text and background selected by the user. 1. A method for displaying an e-book using a combination of colors for text and background that have a reduced myopiagenic effect compared to black text on white background , the method comprising:presenting a user with one or more combinations of colors for the text and background identified as having a reduced myopiagenic effect, wherein none of the presented combinations comprise either black or white text or either black or white background, and, when viewed by the user's retina, an image composed of text and background rendered in any of the presented color combinations provides reduced center-surround contrast on the user's retina compared to the image viewed as black text on white background;receiving a selection of one of the color combinations from the user; anddisplaying the e-book file using the combination of colors for the text and background selected by the user.2. The method of claim 1 , wherein the reduced center-surround contrast due to the color combinations yields a myopiagenic effect reduced by at least 35% as calculated using a myopia scale that calculates a center-surround contrast of a ...

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Номер записи: 88
06-08-2015 дата публикации

FIRE PROTECTION DEVICE AND METHOD FOR FIRE PROTECTION OF AN INDUSTRIAL OIL COOKER

Номер: US20150217152A1
Автор: ALMEIDA Jose L., Bowder, Goyette Chad A., JR. Thomas W., Magnone Zachary L.
Принадлежит:

Fire protection mist nozzles for industrial oil cookers, oil cookers with fire protection systems, and method of oil cooker fire protection are provided. The mist nozzles operate at pressures between 170 and 250 psi, and provide a unique distribution pattern that allows for variable installations for protection in certain operative environments including oil cookers with various hood configurations. The fire protection nozzles includes a base defining an inlet and an outlet along an axis. The base includes an orifice having an inlet diameter and an outlet diameter. The outlet diameter is preferably greater than the inlet diameter; and the orifice defines a K-factor of less than 1.0 gpm/psi½. The nozzle includes a diffuser aligned with the orifice. The diffuser has a preferably substantially domed portion with a maximum diameter that is less than the summation of the inlet diameter and the outlet diameter of the orifice. 1. A fire protection nozzle comprising:a base defining an inlet and an outlet along an axis, the base having an orifice, the orifice have an inlet diameter and an outlet diameter, the outlet diameter being greater than the inlet diameter, the orifice defining a K-factor of less than 1.0 gpm/psi½; anda diffuser having a substantially domed portion, the diffuser being aligned with the orifice, the substantially domed portion having a maximum diameter being less than a summation of the inlet diameter and the outlet diameter of the orifice.2. The nozzle of claim 1 , wherein the orifice is defined by an orifice member having a surface substantially perpendicular to the axis and exposed to the inlet claim 1 , the surface defining a first area claim 1 , the inlet diameter defining a second area claim 1 , the first area being greater than the second area claim 1 , the orifice having at least a tapering wall between the inlet diameter and the outlet diameter claim 1 , the tapering wall tapers away from and along the axis.3. The nozzle of claim 2 , wherein a ...

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Номер записи: 89
16-10-2014 дата публикации

TREE STAND TOOLS

Номер: US20140304968A1
Автор: JR. Thomas W., LaFleur Mark E., LOWRY
Принадлежит:

An illustrative example device for use with a tree stand includes a beam that is configured to slide into engagement with a climbing stick. The beam supports at least one of a hoisting member or a gear support member. A hoisting member allows an individual to hoist a tree stand up into a tree with greater efficiency and stability. A gear support member provides a convenient place to situate hunting gear within reach when an individual is situated in a tree. 1. A device for use with a tree stand , the device comprising:a beam including a first portion configured to move into engagement with a climbing stick; anda hoisting mechanism supported by the beam at a position spaced from the first portion, the hoisting mechanism being configured to facilitate hoisting a tree stand.2. The device of claim 1 , wherein the hoisting mechanism comprises a pulley.3. The device of claim 1 , wherein the first portion of the beam is configured to be at least partially received into a portion of a climbing stick.4. The device of claim 3 , wherein the first portion is tapered and includes a smaller outside dimension near an end of the beam and a larger outside dimension closer to a central portion of the beam.5. The device of claim 3 , comprising a pin and wherein the first portion comprises an opening configured to receive the pin when the first portion is received into the portion of the climbing stick claim 3 , the pin being operative to secure the beam in a selected position relative to the climbing stick.6. The device of claim 1 , wherein the first portion of the beam is configured to be received over a portion of a climbing stick.7. The device of claim 1 , wherein the beam includes a second portion adjacent the first portion;the beam includes a third portion adjacent the second section;the first portion is generally parallel to the third portion; andthe second portion is generally perpendicular to the first portion and the third portion.8. The device of claim 1 , wherein the first ...

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Номер записи: 90
03-08-2017 дата публикации

COMPOSITIONS AND METHODS FOR INHIBITING "STIMULATOR OF INTERFERON GENE" -DEPENDENT SIGNALLING

Номер: US20170218008A1
Автор: Dubensky, JR. Thomas W., Kanne David B.
Принадлежит:

The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING-dependent TBK1 activation and the resulting production of type I interferon. 2. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein one or both of R2 and R6 are independently an unsubstituted alkynyl of from 2-9 carbons.3. A substantially pure cyclic purine dinucleotide composition according to claim 2 , wherein one or both of R2 and R6 is propargyl.4. A substantially pure cyclic purine dinucleotide composition according to claim 2 , wherein one or both of R2 and R6 is homopropargyl.5. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein Xand Xare both S.6. A substantially pure cyclic purine dinucleotide composition according to claim 5 , wherein the cyclic purine dinucleotides present in the composition comprise one or more substantially pure Sp claim 5 ,Sp claim 5 , Rp claim 5 ,Rp claim 5 , SpRp claim 5 , or Rp claim 5 ,Sp stereoisomers.7. A substantially pure cyclic purine dinucleotide composition according to claim 6 , wherein R1 and R5 are independently selected from the group consisting of adenine claim 6 , guanine claim 6 , inosine claim 6 , and xanthine.8. A substantially pure cyclic purine dinucleotide composition according to claim 7 , wherein one or both of R1 and R5 are adenine.9. A substantially pure cyclic purine dinucleotide composition according to claim 7 , wherein one or both of R1 and R5 are guanine.10. A substantially pure cyclic purine dinucleotide composition according to claim 9 , wherein R1 is adenine and R5 is guanine.11. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein the cyclic ...

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Номер записи: 91
02-07-2020 дата публикации

Active Agent Delivery Devices and Methods for Using the Same

Номер: US20200206025A1
Автор: Chalberg, JR. Thomas W., Kahatt Espir Gabriel, Williams Michael Edward
Принадлежит:

Active agent delivery devices are provided. Aspects of the devices include an active agent delivery component having an active agent delivery system; and an actuator component, where the active agent delivery component is release-ably engaged to the actuator component. The actuator component includes an active agent delivery system actuator. Either or both components may contain one or more elements of a pain mitigation system and/or a smart device system, e.g., an identifier and identifier reader. Also provided are methods of using the devices. 115-. (canceled)16. An active agent delivery device for delivering a therapeutic agent to a target tissue delivery site , the device comprising:(a) an active agent delivery component comprising an active agent delivery system comprising a needle; and (i) a body having a proximal end and a distal end;', '(ii) an active agent delivery system actuator configured to actuate the active agent delivery system; and', '(iii) a cooling system comprising a cold element configured to maintain a temperature of the target tissue ranging from about +5 to −80° C.;, '(b) an actuator component comprisingwherein the active agent delivery component is release-ably engaged to the distal end of the actuator component.17. The device according to claim 16 , wherein the cooling system is configured to mitigate pain at the target tissue delivery site.18. The device according to claim 16 , wherein the cooling system comprises a low-temperature substance.19. The device according to claim 16 , wherein the actuator component comprises a motor.20. The device according to claim 16 , wherein the device is configured to deliver a therapeutic agent.21. The device according to claim 20 , wherein the therapeutic agent is a VEGF antagonist.22. The device according to claim 20 , wherein the therapeutic agent is a complement inhibitor.23. The device according to claim 20 , wherein the therapeutic agent is delivered in a active agent composition.24. The device ...

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Номер записи: 92
23-10-2014 дата публикации

ENGINEERED LISTERIA AND METHODS OF USE THEREOF

Номер: US20140315314A1
Автор: Cook David N., Dubensky, JR. Thomas W., Lauer Peter M., Skoble Justin
Принадлежит: ADURO BIOTECH

The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes. 1. A method of introducing a heterologous nucleic acid sequence of interest into a bacterial genome , comprising:(a) recombinantly introducing a bacterial attachment site (attBB′) which is not present in the bacterial genome into a pre-determined site of the genome of a population of bacteria; (i) a first nucleic acid sequence encoding a first recombinase binding site heterologous to the bacterial genome and a second nucleic acid sequence encoding a second recombinase binding site heterologous to the bacterial genome, wherein the first and second recombinase binding sites are two Lox sites or two Frt sites,', '(ii) a third nucleic acid sequence encoding a selection marker, wherein the first and second recombinase binding sites flank the third nucleic acid sequence encoding a selection marker,', '(iii) a fourth nucleic acid sequence encoding a phage integrase selected to mediate integration at the first bacterial attachment site, wherein the first and second recombinase binding sites flank the fourth nucleic acid sequence,', '(iv) a fifth nucleic acid sequence not flanked by the recombinase binding sites, the fifth nucleic acid sequence encoding the heterologous nucleic acid sequence of interest, and', '(v) a sixth nucleic acid sequence not flanked by the recombinase binding sites, the sixth nucleic acid sequence encoding a phage attachment site (attPP′) site compatible with first bacterial attachment site,, '(b) contacting the population of bacteria with a plasmid comprising'}under conditions selected to cause integration of the plasmid into the pre-determined site of the genome mediated by the phage integrase, wherein the plasmid lacks an origin of replication that is active in the ...

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Номер записи: 93
27-08-2015 дата публикации

LOW-TRAVEL KEY MECHANISMS USING BUTTERFLY HINGES

Номер: US20150243457A1
Автор: BROCK John M., Hendren Keith J., JR. Thomas W., Leong Craig C., Niu James J., Wilson
Принадлежит:

A key mechanism including one or more butterfly hinges. Each butterfly hinge may include a double wing design operative to move between a depressed position and non-depressed position. Hinged coupling mechanisms couple respective arms of the wings together. Additionally or alternatively, a key mechanism can include one or more half-butterfly hinges. Each half-butterfly hinge includes a double wing design operative to move between a depressed position and non-depressed position. A hinged coupling mechanism couples one set of corresponding arms of the wings together, while the other set of corresponding arms are not coupled together. 1. A key mechanism , comprising:a keycap assembly;a support structure;a half-butterfly hinge comprising two separate wings positioned adjacent to each other such that a cavity is formed between the two wings, each wing comprising a major arm and a minor arm shorter than the major arm, each wing comprising a pair of pivot pins coupled to the support structure and a pair of keycap pins coupled to the keycap assembly; anda coupling mechanism coupling the major arms of the half-butterfly hinge together.2. The key mechanism of claim 1 , further comprising a switch secured within the cavity between the keycap assembly and the support structure.3. The key mechanism of claim 2 , wherein the switch comprises an upper conductive deformable structure disposed over a lower conductive deformable structure claim 2 , wherein the switch is closed when the upper conductive deformable structure comes in contact with the lower conductive deformable structure.4. The key mechanism of claim 1 , wherein a first pivot of the pair of pivot pins is coupled to the support structure by a c-clip retaining member and a second pivot of the pair of pivot pins is coupled to the support structure by an L-shaped retaining member.5. The key mechanism of claim 1 , wherein a first pivot of the pair of pivot pins is coupled to the support structure by a c-clip retaining member ...

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Номер записи: 94
16-08-2018 дата публикации

Electronic Device Display Structures

Номер: US20180232009A1
Автор: Garelli Adam T., Giddings Joss Nathan, Hendren Keith J., JR. Thomas W., Mathew Dinesh C., Posner Bryan W., Qi Jun, Wang Paul Xiaopeng, Wilson, Yin Victor H.
Принадлежит:

An electronic device may have a housing in which a display is mounted. A gasket may be mounted in a groove between the display and housing. The gasket may contain an embedded stiffener. Corner brackets may be installed in the corners of the housing. The housing may have inner and outer concentric ribs. Recesses in the housing may be configured to receive the corner brackets. The recesses may be formed between the inner and outer concentric ribs. Gap filling structures such as a foam layer may be interposed between a rear housing wall and a display backlight unit. Display color variations may be corrected by using a backlight unit having an array of light-emitting diodes of different colors. An electrostatic discharge protection layer may be grounded to a housing using conductive tape. Black edge coatings and adhesive-based structures may block stray light. Camera window regions may be supported using adhesive. 1. An electronic device , comprising:a housing having at least one surface;a display mounted in the housing;backlight structures in the housing that are configured to provide light for the display; andan adhesive-based structure configured to attach the display to the surface, wherein the adhesive-based structure is configured to prevent leakage of the light.2. The electronic device defined in wherein the adhesive-based structure comprises black adhesive.3. The electronic device defined in wherein the adhesive-based structure comprises a first layer of adhesive attached to the display claim 2 , a second layer of adhesive attached to the surface claim 2 , and a layer of foam interposed between the first and second layers of adhesive.4. The electronic device defined in wherein the first and second layers of adhesive comprise black adhesive and wherein the layer of foam comprises black foam claim 3 , wherein the display has a rectangular periphery claim 3 , and wherein the adhesive-based structure runs along the rectangular periphery.5. The electronic device ...

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Номер записи: 95
01-08-2019 дата публикации

OPHTHALMIC LENSES WITH LIGHT SCATTERING FOR TREATING MYOPIA

Номер: US20190235279A1
Автор: Chalberg, HONES Peter, JR. Thomas W.
Принадлежит:

An ophthalmic lens that includes a lens material having two opposing curved surfaces, the curved surfaces defining a lens axis; and a light scattering region surrounding a clear aperture. The clear aperture and the light scattering region are substantially centered on the lens axis, and the light scattering region has a plurality of spaced apart scattering centers (e.g., on a lens surface and/or embedded in the lens material) sized and shaped to scatter incident light, the scattering centers being arranged in a pattern that includes a random variation in spacing between adjacent dots and/or a random variation in dot size. 1. An ophthalmic lens , comprising:a lens material having two opposing curved surfaces; anda scattering region surrounding a clear aperture, wherein the scattering region has a plurality of spaced apart scattering centers sized and shaped to scatter incident light, the scattering centers being arranged in a pattern that includes an irregular variation in spacing between adjacent scattering centers and/or an irregular variation in scattering centers size.2. The ophthalmic lens of claim 1 , wherein the scattering centers are positioned relative to a regular array of lattice cites claim 1 , wherein each scattering center is displaced in at least one dimension from a corresponding one of the lattice sites by an amount equal to or less than a jitter amplitude claim 1 , the jitter amplitude being a fraction of the distance between adjacent lattice sites.3. The ophthalmic lens of claim 2 , wherein the jitter amplitude is 0.5 or less.4. The ophthalmic lens of claim 1 , wherein the scattering centers have a dimension that varies randomly from a nominal value claim 1 , the random variation being equal to or less than a jitter amplitude.5. The ophthalmic lens of claim 4 , wherein the jitter amplitude is 0.5 times the nominal value or less.6. The ophthalmic lens of claim 1 , wherein the scattering centers have a volume that varies randomly from a nominal ...

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Номер записи: 96
20-11-2014 дата публикации

Methods for Fabricating Display Structures

Номер: US20140340831A1
Автор: Augenbergs Peteris K., Degner Brett W., Hotelling Steve, JR. Thomas W., Ligtenberg Chris, Mathew Dinesh C., Posner Bryan W., Sung Kuo-Hua, Wilson, Yin Victor H., Youngs Lynn, Zhong John Z.
Принадлежит:

An electronic device display may have a color filter layer and a thin film transistor layer. A layer of liquid crystal material may be interposed between the color filter layer and the thin film transistor layer. A layer of polarizer may be laminated onto the surface of the color filter layer. Laser trimming may ensure that the edges of the polarizer are even with the edges of the color filter layer. The thin film transistor layer may have an array of thin film transistors that control pixels of the liquid crystal material in the display. Driver circuitry may be used to control the array. The driver circuitry may be encapsulated in a planarized encapsulant on the thin film transistor layer or may be mounted to the underside of the color filter layer. Conductive structures may connect driver circuitry on the color filter layer to the thin film transistor layer. 16-. (canceled)7. A computer , comprising:a housing structure; and a color filter layer;', 'driver circuitry comprising at least an integrated circuit mounted on the color filter layer;', 'a thin-film transistor layer;', 'an opaque layer formed in a border around a periphery of the display and extending beyond a pixel area of the display that blocks inactive peripheral portions of the display from view;', 'an opening in the opaque layer located beyond the pixel area of the display; and', 'a camera in the housing structure that receives light through the opening the opaque layer., 'a display in the housing structure that includes8. The computer of claim 7 , wherein the opening is at least one of circular or rectangular.9. The computer of claim 7 , further comprising a polarizer layer.10. The computer of claim 9 , wherein the polarizer layer includes a polarizer layer opening that aligns with the opening in the opaque layer.11. The computer of claim 10 , wherein the polarizer layer opening is filled with an epoxy fill.12. The computer of claim 11 , wherein the epoxy fill comprises an ultraviolet curable epoxy.13 ...

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Номер записи: 97
20-11-2014 дата публикации

COMPOSITIONS AND METHODS FOR INHIBITING "STIMULATOR OF INTERFERON GENE" -DEPENDENT SIGNALLING

Номер: US20140341976A1
Автор: Dubensky, JR. Thomas W., Kanne David B.
Принадлежит: Aduro Biotech, Inc.

The present invention provides cyclic-di-nucleotide (CDN) compounds that inhibit signaling at a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides which inhibit STING-dependent TBK1 activation and the resulting production of type I interferon. 1. A composition comprising:one or more cyclic purine dinucleotides that inhibit STING-dependent type I Interferon production.4. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein one or both of R2 and R6 are independently an unsubstituted straight chain alkyl of from 1 to 18 carbons claim 1 , an unsubstituted alkenyl of from 1-9 carbons claim 1 , an unsubstituted alkynyl of from 1-9 carbons claim 1 , or an unsubstituted aryl claim 1 , and most preferably selected from the group consisting of selected from the group consisting of allyl claim 1 , propargyl claim 1 , homoallyl claim 1 , homopropargyl claim 1 , methyl claim 1 , ethyl claim 1 , propyl claim 1 , isopropyl claim 1 , isobutyl claim 1 , cyclopropylmethyl claim 1 , and benzyl.5. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein one or both of R2 and R6 are allyl.6. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein one or both of R2 and R6 comprise a propargyl.7. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein one or both of R2 and R6 are methyl.8. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein one or both of R2 and R6 are ethyl.9. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein one or both of R2 and R6 are propyl.10. A substantially pure cyclic purine dinucleotide composition according to claim 1 , wherein one or both of R2 and R6 are benzyl.11 ...

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Номер записи: 98
20-11-2014 дата публикации

TREATMENT OF AMD USING AAV SFLT-1

Номер: US20140341977A1
Автор: Chalberg, Constable Ian J., JR. Thomas W., Lai Chooi-May, Rakoczy Elizabeth P.
Принадлежит: Avalanche Australia Pty Ltd.

The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by administering subretinally a pharmaceutical composition comprising a pharmaceutically effective amount of a vector comprising a nucleic acid encoding soluble Fms-related tyrosine kinase-1 (sFlt-1) protein to the human subject. 141-. (canceled)42. A method for the treatment or prophylaxis of ocular neovascularization in a human subject having or at risk for developing ocular neovascularization , the method comprising: administering to the retina of the human subject a pharmaceutically effective amount of a pharmaceutical composition comprising a nucleic acid encoding sFLT-1.43. The method of claim 42 , wherein the ocular neovascularization is associated with a condition selected from the group consisting of: age-related macular degeneration (AMD) claim 42 , retinal neovascularization claim 42 , choroidal neovascularization claim 42 , diabetic retinopathy claim 42 , retinal vein occlusion claim 42 , diabetic macular edema claim 42 , diabetic retinal ischemia claim 42 , ischemic retinopathy and diabetic retinal edema.44. The method of claim 43 , wherein the condition is AMD.45. The method of claim 42 , wherein the pharmaceutical composition comprises a recombinant virus claim 42 , the virus selected from the group consisting of: adeno-associated virus (AAV) claim 42 , adenovirus claim 42 , helper-dependent adenovirus claim 42 , retrovirus claim 42 , herpes simplex virus claim 42 , lentivirus claim 42 , poxvirus claim 42 , hemagglutination virus of Japan-liposome (HVJ) complex claim 42 , Moloney murine leukemia virus claim 42 , and HIV-based virus.46. The method of claim 45 , wherein the virus is AAV.471. The method of claim claim 45 , wherein the sFLT-1 nucleic acid encodes at least 1 dimerization domain.48. The method of claim 42 , wherein a reduction in neovascularization claim 42 , as observed by a Fluorscein ...

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Номер записи: 99
07-09-2017 дата публикации

SIGNAL PEPTIDE FUSION PARTNERS FACILITATING LISTERIAL EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS OF PREPARATION AND USE THEREOF

Номер: US20170253637A1
Автор: Brockstedt Dirk, Dubensky, Fasso Marcella, Hanson William G., JR. Thomas W., Lauer Peter M., Leong Meredith Lai Ling, Skoble Justin
Принадлежит:

The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any PEST sequences native to the sequence, and/or for certain hydrophobic residues. 1. A method for stimulating an immune response to a non-Listerial antigen in a human comprising:{'i': Listeria', 'Listeria, 'claim-text': a polypeptide derived by recombinant modification of a secreted Listerial protein sequence, the secreted Listerial protein sequence in its unmodified form comprising a signal sequence and one or more PEST motifs, the modification comprising removal of each of the PEST motifs by deletion or substitution by one or more residues such that the polypeptide lacks any PEST motif; and', 'a non-Listerial antigen, 'administering an effective amount of the bacterium to the human, the bacterium expressing the non-Listerial antigen as a fusion protein comprisingwherein the non-Listerial antigen is expressed in one or more cells of the human.2. The method of claim 1 , wherein the secreted Listerial protein sequence is ActA or LLO.3. The method of claim 2 , wherein the modification further comprises truncation of the secreted Listerial protein sequence at about residue 100.4. The method of claim 1 , wherein the polypeptide retains the signal sequence of the secreted Listerial protein sequence in unmodified form.5. The method of claim 1 , wherein the modification further comprises:removal of one or more hydrophobic domains which are not part of the signal sequence of the secreted Listerial protein ...

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Номер записи: 100