IMAGE TO TARGET COMPARATOR SOFTWARE

A system, method, and machine-readable storage medium for detecting changes in images are provided herein. The system includes an original grid and an image detection software program. The original grid represents an original image. The image detection software program detects changes between the original image and the processed image as follows: receiving a description of the original grid, the processed image and a set of tolerance parameters; scanning horizontally the pixels of the processed image into horizontal runs, scanning vertically the pixels of the processed image into vertical runs, and saving each of the plurality of vertical and horizontal coordinates within the predefined vertical and horizontal tolerance; determining a plurality of processed intersection coordinates; comparing a portion of the plurality of processed intersection coordinates to a portion of the plurality of original grid line intersection coordinates; and providing an image comparison result. 1. A system for detecting changes in images comprising:an original grid representing an original image; and receiving a description of said original grid, said description including a plurality of original grid line intersection coordinates associated therewith;', 'receiving said processed image and a set of tolerance parameters associated therewith, said processed image being represented as pixels, said set of tolerance parameters including a predefined vertical tolerance and a predefined horizontal tolerance;', 'scanning horizontally the pixels of said processed image into horizontal runs, the horizontal runs determining a plurality of vertical coordinates of said processed image, saving each of said plurality of vertical coordinates within said predefined vertical tolerance;', 'scanning vertically the pixels of said processed image into vertical runs, the vertical runs determining a plurality of horizontal coordinates of said processed image, saving each of the horizontal coordinates within ...

Harnessing Cell Dynamics to Engineer Materials

The invention features synthetic materials and methods for inducing cell behavior. Matrix materials induce cell differentiation and cell manipulation based on mechanical and physical characteristics of the materials rather than chemical characteristics. 1. A method of inducing differentiation of a stem cell comprising contacting said stem cell with a 3-dimensional material comprising a pre-determined density of an adhesion molecule and a predetermined stiffness , wherein said density and said stiffness determine a cell type into which said stem cell differentiates.2. The method of claim 1 , wherein said stiffness in the range of 22-45 kPA induces said stem cell to differentiate into an osteogenic lineage.3. A method of inducing molecular manipulation of a bioactive composition by a cell claim 1 , comprising contacting a cell with said composition in a matrix claim 1 , wherein said matrix induces traction on said matrix by said cell thereby mediating molecular manipulation of said composition.4. The method of claim 3 , wherein said composition is a prodrug and wherein said traction leads to transformation of said prodrug into an active form of said prodrug. This invention was made with Government support under R37 DE013033 awarded by the National Institutes of Health. The Government has certain rights in the invention.Over the recent decades, it has become apparent that cells receive information from their microenvironment. However, the mechanism(s) by which the information is conveyed has been elusive.The invention is based on the discovery that stiffness of a composition encountered by cell triggers behavior of the cell, e.g., cell differentiation and cell traction. Another characteristic of the composition encountered, density of adhesion molecules, also influences cell behaviors such as differentiation and traction.Accordingly, the invention features synthetic materials and methods for inducing cell behavior. Adhesion molecule presentation is coupled to ...

Delivering a video stream

Delivering a video stream is disclosed. A request for the video stream is received. A past portion of the video stream is delivered to a client. The past portion has a marker time that precedes a current time by an interval that corresponds to a buffer length in a client buffer. Receiving a video stream is also disclosed. A request for the video stream is transmitted. A past portion of the video stream is received. The received past portion has a marker time that precedes a current time by an interval that corresponds to a buffer length in a client buffer.

METHOD FOR PRODUCING METALIZED FIBROUS COMPOSITE SHEET WITH OLEFIN COATING

A composite sheet is manufactured by depositing a multi-layer coating on the outer surface of a substrate, the coating comprising a metal layer and an outer polymeric layer formed from a precursor comprising a polymerizable composition that includes a olefin group and a moisture curable group, such as an isocyanate or silane group. After the precursor is applied, the composite sheet is exposed to both beam radiation and moisture, which respectively promote polymerization and curing at different sites of the precursor. The function of the cured polymeric layer includes protecting the metal layer from corrosion. The amenability of the isocyanate or silane functionality to moisture-promoted coupling promotes substantially full conversion and curing of the precursor, even of portions of the substrate that are geometrically shadowed from incident beam radiation. 1. A process for manufacturing a composite sheet comprising:providing a substrate having a first outer surface and an opposing second outer surface;metalizing the first outer surface of the substrate to form thereon a metal layer;depositing on the metal layer a precursor of an outer polymeric coating layer to form a precursor film, the precursor comprising a dual-function composition including an olefin group and a moisture curable group; and creating free radicals in the precursor to induce polymerization of at least a portion thereof; and', 'exposing the precursor film to water vapor., 'treating the precursor to form the outer polymeric coating layer, the treating comprising2. The process of claim 1 , wherein the creating of free radicals comprises at least one of exposing the precursor film to a plasma discharge or irradiating the first outer surface with beam radiation provided by a radiation source.3. The process of claim 1 , wherein the creating of free radicals is accomplished by exposing the precursor film to a plasma discharge.4. The process of claim 1 , wherein the creating of free radicals is ...

METALIZED FIBROUS COMPOSITE SHEET WITH OLEFIN COATING

A composite sheet comprises a substrate and a multi-layer coating on its outer surface, the coating comprising a metal layer and an outer polymeric layer formed from a precursor comprising a polymerizable composition that includes a olefin group and a moisture curable group, such as an isocyanate or silane group. The function of the polymeric layer includes protecting the metal layer from corrosion. A production process for the composite sheet includes depositing the precursor and exposing it to both beam radiation and moisture, which respectively promote polymerization and curing at different sites of the precursor. The amenability of the isocyanate or silane functionality to moisture-promoted coupling promotes substantially full conversion and curing of the precursor, even of portions of the substrate that are geometrically shadowed from incident beam radiation. 1. A composite sheet comprising:a substrate having a first outer surface and an opposing second outer surface; and a metal layer overlaying the first outer surface of the substrate; and', 'an outer polymeric layer overlaying the metal layer, and comprising a three-dimensional network containing a plurality of linkages having a structure -A-R-B-, wherein A is an olefin group polymerically linked to another olefin group, B is a silane or isocyanate group cross-linked to another silane or isocyanate group, and R is a diradical comprising at least one of a C1 to C20 alkylene or aryl, each optionally substituted with a member selected from the group consisting of O, N, P and S, and wherein the alkylene can be linear, branched, or cyclic., 'a multi-layer coating on the first outer surface of the substrate, the multi-layer coating comprising2. The composite sheet of claim 1 , wherein the substrate comprises a nonwoven sheet selected from the group consisting of flash-spun plexifilamentary sheets claim 1 , spunbond nonwoven sheets claim 1 , spunbond-meltblown nonwoven sheets claim 1 , spunbond-meltblown-spunbond ...

STIMULUS RESPONSIVE NANOPARTICLES

Disclosed are various embodiments of methods and systems related to stimulus responsive nanoparticles. In one embodiment includes a stimulus responsive nanoparticle system, the system includes a first electrode, a second electrode, and a plurality of elongated electro-responsive nanoparticles dispersed between the first and second electrodes, the plurality of electro-responsive nanorods configured to respond to an electric field established between the first and second electrodes. 1. A stimulus responsive nanoparticle system , comprising:a first electrode;a second electrode substantially parallel to the first electrode; anda plurality of elongated electro-responsive nanoparticles having a biplaner director that are dispersed within a nonconductive fluid sealed between the first and second electrodes, the plurality of electro-responsive nanoparticles responsive to an electric field established between the first and second electrodes, where the plurality of elongated electro-responsive nanoparticles are configured to substantially align with the electric field when established.2. The system of claim 1 , wherein the plurality of elongated electro-responsive nanoparticles are electro-responsive nanorods.3. The system of claim 2 , wherein the elongated electro-responsive nanoparticles are reactive mesogen nanorods.4. The system of claim 1 , wherein the plurality of elongated electro-responsive nanoparticles rotate to substantially align with the electric field established between the first and second electrodes.5. The system of claim 1 , wherein the plurality of elongated electro-responsive nanoparticles are dispersed between the first and second electrodes in a nonconductive dispersion agent.6. The system of claim 5 , wherein the nonconductive dispersion agent is silicone oil.7. The system of claim 1 , wherein the first and second electrodes each comprise a conducting substrate.8. The system of claim 1 , wherein the first and second electrodes each comprise a conducting ...

METHOD FOR PRODUCING METALIZED FIBROUS COMPOSITE SHEET WITH OLEFIN COATING

A composite sheet is manufactured by depositing a multi-layer coating on the outer surface of a substrate, the coating comprising a metal layer and an outer polymeric layer formed from a precursor comprising a polymerizable composition that includes a olefin group and a moisture curable group, such as an isocyanate or silane group. After the precursor is applied, the composite sheet is exposed to beam radiation or plasma discharge, ozone, and moisture, which respectively promote polymerization and curing at different sites of the precursor. The function of the cured polymeric layer preferably includes protecting the metal layer from corrosion. The amenability of the isocyanate or silane functionality to moisture-promoted coupling promotes substantially full conversion and curing of the precursor, even of portions of the substrate that are geometrically shadowed from incident beam radiation. 1. A process for manufacturing a composite sheet comprising:providing a substrate having a first outer surface and an opposing second outer surface;metalizing the first outer surface of the substrate to form thereon a metal layer;depositing on the metal layer a precursor of an outer polymeric coating layer to form a precursor film, the precursor comprising a dual-function composition including an olefin group and a moisture curable group; and at least one of exposing the precursor film to a plasma discharge or irradiating the first outer surface with beam radiation provided by a radiation source to induce conversion of at least a portion of the precursor;', 'exposing the precursor film to ozone; and', 'exposing the precursor film to water vapor., 'treating the precursor to form the outer polymeric coating layer, the treating comprising2. The process of claim 1 , wherein the treating comprises exposing the precursor film to a plasma discharge.3. The process of claim 1 , wherein the treating comprises irradiating the first outer surface with beam radiation provided by a radiation ...

METHOD FOR PRODUCING METALIZED FIBROUS COMPOSITE SHEET WITH OLEFIN COATING

A composite sheet is manufactured by depositing a multi-layer coating on the outer surface of a substrate, the coating comprising a metal layer and an outer polymeric layer formed from a precursor comprising a composition capable of being polymerized and/or cross-linked by free-radical processes. After the precursor is applied, the composite sheet is exposed to beam radiation and ozone, which both promote conversion of the precursor. The function of the cured polymeric layer includes protecting the metal layer from corrosion. The use of both beam radiation and ozone promotes substantially full conversion and curing of the precursor, even in portions of the substrate that are geometrically shadowed from incident beam radiation. 1. A process for manufacturing a composite sheet comprising:providing a substrate having a first outer surface and an opposing second outer surface;metalizing the first outer surface of the substrate to form thereon a metal layer;depositing on the metal layer a precursor of an outer polymeric coating layer to form a precursor film, the precursor comprising a composition capable of being converted by free-radical processes; and 'creating free radicals in the precursor to induce conversion of at least a portion thereof, the creating comprising exposure of the precursor film to ozone.', 'treating the precursor to form the outer polymeric coating layer, the treating comprising2. The process of claim 1 , wherein the creating of free radicals further comprises at least one of exposing the precursor film to a plasma discharge or irradiating the first outer surface with beam radiation provided by a radiation source.3. The process of claim 2 , wherein the creating of free radicals comprises exposing the precursor film to a plasma discharge.4. The process of claim 2 , wherein the creating of free radicals comprises irradiating the first outer surface with beam radiation provided by a radiation source.5. The process of claim 4 , wherein the beam ...

Injectable, Pore-Forming Hydrogels for Materials-Based Cell Therapies

The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time. 1. A composition comprising a first hydrogel and a second hydrogel , wherein said first hydrogel degrades at least 10% faster than said second hydrogel , and wherein said first hydrogel or said second hydrogel comprises an isolated cell.2. The composition of claim 1 , wherein said second hydrogel is cross-linked around said first hydrogel or wherein said first hydrogel is physically entrapped in said second hydrogel.3. The composition of claim 1 , further comprising a bioactive factor selected from the group consisting of vascular endothelial growth factor (VEGF) claim 1 , acidic fibroblast growth factor (aFGF) claim 1 , basic fibroblast growth factor (bFGF) claim 1 , placenta growth factor (PIGF) claim 1 , platelet derived growth factor (PDGF) claim 1 , leptin claim 1 , hematopoietic growth factor (HGF) claim 1 , VEGF receptor-1 (VEGFR-1) claim 1 , VEGFR-2 claim 1 , a member of the bone morphogenetic protein (BMP) family claim 1 , granulocyte/macrophage colony stimulating factor (GM-CSF) claim 1 , FMS-like tyrosine kinase 3 ligand (Flt3 ligand) claim 1 , hepatocyte growth factor claim 1 , stromal derived factor 1 (SDF-1) claim 1 , insulin like growth factor (IGF) claim 1 , anti-VEGF antibody claim 1 , anti-aFGF antibody claim 1 , anti-bFGF antibody claim 1 , anti-PIGF antibody claim 1 , anti-leptin antibody claim 1 , anti-HGF antibody claim 1 , anti-VEGFR-1 antibody claim 1 , anti-VEGFR-2 antibody claim 1 , anti-PDGF antibody claim 1 , anti-BMP antibody claim 1 , anti-Flt3 ligand claim 1 , anti-IGF antibody.4. The composition of claim 1 , wherein said cell is a mesenchymal stem cell claim 1 , a myoblast claim 1 , a ...

NOVEL HALOGEN-SUBSTITUTED COMPOUNDS

The invention relates inter alia to halogen-substituted compounds of the general formula (I) 7. A compound of formula (I) capable of being used for controlling insects , arachnids and nematodes.8. Pharmaceutical composition comprising at least one compound according to .9. Compound according to that comprises a medicament.10. A compound according to capable of being used for preparing a pharmaceutical composition for controlling parasites on animals.11. Process for preparing crop protection compositions comprising mixing a compound according to and one or more customary extenders and/or surfactants.12. Method for controlling pests claim 1 , comprising allowing a compound according to to act on the pests and/or a habitat thereof.13. A compound according to capable of being used for protecting propagation material of a plant. The present application relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects, arachnids and nematodes.It is known that certain halogen-substituted compounds have herbicidal action (cf. J. Org. Chem. 1997, 62(17), 5908-5919, J. Heterocycl. Chem. 1998, 35(6), 1493-1499, WO 2004/035545, WO 2004/106324, US 2006/069132, WO 2008/029084).Furthermore, it is known that certain halogen-substituted compounds are insecticidally active (EP1911751, WO2012-069366, WO2012-080376 & WO2012-107434).In addition, it is known that certain halogen-substituted compounds have FAAH-inhibitory activities (WO 2009/151991).Modern crop protection compositions have to meet many demands, for example in relation to efficacy, persistence and spectrum of their action and possible use. Questions of toxicity, the combinability with other active compounds or formulation auxiliaries play a role, as well as the question of the expense that the synthesis of an active compound requires. Furthermore, resistances may occur. For all these reasons, the search for novel ...

HALOGEN-SUBSTITUTED COMPOUNDS

The invention encompasses inter alia halogen-substituted compounds of the general formula (I) in which the radicals A-A, T, W, Q, Rand Z-Zhave the meanings given in the description. Also described are processes for preparing the compounds of the formula (I). The compounds according to the invention are especially suitable for controlling insects, arachnids and nematodes in agriculture, and ectoparasites in veterinary medicine. 2. Compound of formula (I) according to in which Zand Zindependently of one another represent perhalogenated C-C-alkyl and Zrepresents C-C-alkyl.3. Compound of formula (I) according to in which Zrepresents perfluorinated ethyl (CF) claim 1 , Zrepresents perfluorinated methyl (CF) and Zrepresents methyl.4. Compound of formula (I) according to claim 1 , in which T represents T3 (formula (Ic)) claim 1 , T6 (formula (If)) claim 1 , T7 (formula (Ig)) or T8 (formula (Ih)).5. Compound of formula (I) according to claim 1 , in which Q represents hydrogen claim 1 , C-C-alkyl claim 1 , C-C-cycloalkyl claim 1 , C-C-alkoxy or benzyl.6. Compound of formula (I) according to claim 1 , in whichT represents T3 (formula (Ic)), T6 (formula (If)), T7 (formula (Ig)) or T8 (formula (Ih)) and n in T represents 0;{'sub': 1', '2', '2, 'Arepresents CR, where Rrepresents hydrogen;'}{'sub': 2', '3', '3, 'Arepresents CR, where Rrepresents hydrogen;'}{'sub': 3', '4', '4', '1', '4', '1', '4, 'Arepresents CR, where Rrepresents hydrogen, halogen, (C-C)-alkyl or (C-C)-alkoxy;'}{'sub': 4', '5', '5, 'Arepresents CR, where Rrepresents hydrogen;'}W represents oxygen;n in T represents 0;{'sup': '1', 'sub': 1', '4, 'Zrepresents halogenated (C-C)-alkyl;'}{'sup': '2', 'sub': 1', '4, 'Zrepresents halogenated (C-C)-alkyl;'}{'sup': '3', 'sub': 1', '4, 'Zrepresents (C-C)-alkyl;'}{'sub': 1', '1', '4, 'Rrepresents hydrogen or C-C-alkyl;'}{'sup': 1', '1, 'sub': 1', '6', '3', '6, 'Q represents hydrogen or a group, optionally substituted by at least one radical M, selected from the group ...

COMPOSITIONS FOR SURFACE TREATMENTS

A composition having at least one first component containing a perfluorinated aliphatic structure in which no more than six fluorine bearing carbons are connected in any single straight chain segment, in addition a group providing binding functionality to a surface to be treated or containing at least one polymerisable double bond or containing at least one cross-linkable group, and in addition a divalent radical containing at least one group capable of forming polar interactions or hydrogen bonds, and at least one second component containing a perfluorinated aliphatic structure in which no more than six fluorine bearing carbons are connected in any single straight chain segment and a moiety containing at least one group providing binding functionality to a surface to be treated or containing at least one polymerisable double bond or containing at least one cross-linkable group. 1. A composition comprising; {'br': None, 'i': n', 'm, 'X-(L1)-R′-(L2)-Rf'}, 'a) at least a first compound of Formula A'}in whichn is either 0 or 1;m is either 0 or 1;Rf is a perfluorinated aliphatic structure, branched, linear or cyclic, in which no more than six fluorine bearing carbons are connected in any single straight chain segment, this structure optionally being interrupted by one or more oxygen atoms;X is a moiety containing at least one group providing binding functionality to a surface to be treated, or containing at least one polymerisable double bond, or containing at least one cross-linkable group;R′ is a divalent radical containing at least one group capable of forming polar interactions or hydrogen bonds;L1 and L2 are independently divalent linking radicals which do not form polar interactions or hydrogen bonds and {'br': None, 'i': 'p', 'X-(L3)-Rf'}, 'b) a second compound of Formula B'}in whichp is either 0 or 1;Rf is a perfluorinated aliphatic structure, branched, linear or cyclic, in which no more than six fluorine bearing carbons are connected in any single straight ...

COMPOSITE COMPRISING A NONWOVEN VAPOR PERMEABLE SHEET

A composite laminate comprising at least one moisture vapor permeable nonwoven sheet having first and second surfaces and a fluorinated polymeric coating on the first surface of the sheet wherein (i) the fluorinated polymeric coating is present in an amount such that the total fluorine content of the coated non-woven sheet is 0.05 to no greater than 0.4 gsm, and (ii) the composite laminate, after exposure to wet timber, exhibits a retained hydrohead of at least 60 percent. 1. A composite laminate comprising at least one moisture vapor permeable nonwoven sheet having first and second surfaces and a fluorinated polymeric coating on the first surface of the sheet wherein(i) the fluorinated polymeric coating is present in an amount such that the total fluorine content of the coated non-woven sheet is from 0.05 gsm to no greater than 0.4 gsm, and(ii) the composite laminate, after exposure to wet timber, exhibits a retained hydrohead of at least 60 percent when tested according to Test Method A.2. The nonwoven sheet of wherein the sheet comprises plexifilamentary polyolefin fibers.3. The nonwoven sheet of wherein the polyolefin is polyethylene or polypropylene.4. The composite laminate of further comprising a layer of metal intermediate between the first surface of the polyolefinic sheet and the fluorinated polymeric coating claim 1 , the laminate having an emissivity no greater than 0.25.5. The composite laminate of wherein the metal is aluminum claim 4 , tin claim 4 , zinc claim 4 , titanium nickel claim 4 , gold claim 4 , silver claim 4 , lead claim 4 , copper or alloys thereof.6. The composite laminate of wherein the metal is aluminum.7. The composite laminate of further comprising an anticorrosion layer deposited between the metal layer and the fluorinated polymeric coating.8. A building structure comprising a wall or roofing system comprising wooden sheet board or planks and a composite laminate of wherein the polymeric coating is in contact with the wooden board or ...

ISOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PARASITIC INFECTIONS

The present invention covers new isoquinoline compounds of general formula (I): 7. The compound according to claim 1 , wherein:{'sup': '2', 'claim-text': [{'sub': 3', '2, 'hydrogen, chlorine, iodine, —C(O)—N(CH),'}, {'sup': 12', '13, '—NRR;'}, {'sup': '14', '—OR;'}, {'sup': 15', '15', '15, 'sub': '2', '—SR, —S(O)R, —SOR;'}, {'sub': 2', '2', '3', '2', '3', '3, 'methyl, ethyl, propyl, isopropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, ethenyl, propenyl, cyclopentenyl, cyclohexenyl, each of which is optionally substituted by 1 or 2 substituents independently selected from the group consisting of —OH, cyano, ethoxy-C(O)—, —C(O)—NH, methoxy, NH, N(CH), N(CH)(C(O)CH); and'}, {'sub': 2', '2', '2, 'a monocyclic or a bicyclic heterocycle selected from the group consisting of azetidine, oxetane pyrrolidine, tetrahydrofurane, pyrazolidine, imidazolidine, 1,2,4-triazolidine, piperidine, piperazine, tetrahydropyridine, dihydro-2H-pyrane, 1,2-oxazolidine, 1,2-oxazine, morpholine, thiomorpholine, 3,4-dihydroisoquinoline, 2,3-dihydro-indole, 1,3-dihydro-isoindoel, 3,9-dioxa-7-azabicyclo[3.3.1]nonane, 6-oxa-3-azabicyclo[3.1.1]heptane, 8-oxa-3-azabicyclo[3.2.1]octane, thiophene, imidazole, pyrazole, 1,2,4-triazole, 1,2,3-triazole, 1,2,3,4-tetrazole, pyridine, dihydropyridine pyrimidine, tetrahydropyrimidine, 4-oxa-7-azaspiro[2.5]octane, each of which is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group consisting of fluorine, chlorine, cyano —OH, oxo, —COOH, methoxy-C(O)—, ethoxy-C(O)—, tert-butoxy-C(O)—, —C(O)—NH, methyl, methyl-C(O)—, difluoromethyl, trifluoromethyl, hydroxymethyl-, methoxymethyl-, —NH, —NMe, pyrrolidine,'}], 'Ris selected from the group consisting of'}{'sup': 12', '13, 'claim-text': hydrogen, —NH(—C(O)-methyl), methoxy;', {'sub': 2', '2', '2', '2', '2', '2, 'methyl, ethyl, propyl, isopropyl, butyl, isobutyl, cyclopropyl, cyclobutyl, benzyl, 1-phenylethyl, each of which is optionally substituted by 1, 2 or 3 ...

NOVEL HALOGEN-SUBSTITUTED COMPOUNDS

The invention relates inter alia to halogen-substituted compounds of the general formula (I) 7. A compound according to in which Zrepresents CFCF claim 6 , Zrepresents CF claim 6 , Zrepresents CH claim 6 , the radicals Rand Rrepresent hydrogen claim 6 , Aand Arepresent CH claim 6 , Arepresents CH or N claim 6 , Arepresents C—Cl claim 6 , W represents oxygen and Q represents 1-cyanocyclopropyl or cyclopropyl.8. A compound formula (I) according to for controlling one or more insects claim 1 , arachnids and/or nematodes.9. A pharmaceutical composition comprising at least one compound according to .10. A compound according to for use as a medicament.11. A compound according to for producing a pharmaceutical composition for controlling one or more parasites on animals.12. A process for producing a crop protection composition comprising mixing a compound according to and one or more customary extenders and/or surfactants.13. A method for controlling one or more pests claim 1 , comprising allowing a compound according to to act on the pests and/or a habitat thereof.14. A compound according to for protecting the propagation material of one or more plants. The present application relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects, arachnids and nematodes.It is known that similar compounds are used as FAAH inhibitors [WO2009-152025], LXR modulators [WO2007-002559] and ATP binding cassette transporter modulators [WO2004-080972].Modern crop protection compositions have to meet many demands, for example in relation to extent, persistence and spectrum of their action and possible use. Questions of toxicity and of combinability with other active compounds or formulation auxiliaries play a role, as does the question of the expense that the synthesis of an active compound requires. In addition, resistances can occur. For all these reasons, the search for ...

METALIZED FIBROUS COMPOSITE SHEET WITH OLEFIN COATING

A composite sheet comprises a substrate and a multi-layer coating on its outer surface, the coating comprising a metal layer and an outer polymeric layer formed from a precursor comprising a polymerizable composition that includes a olefin group and a moisture curable group, such as an isocyanate or silane group. The function of the polymeric layer includes protecting the metal layer from corrosion. A production process for the composite sheet includes depositing the precursor and exposing it to both beam radiation and moisture, which respectively promote polymerization and curing at different sites of the precursor. The amenability of the isocyanate or silane functionality to moisture-promoted coupling promotes substantially full conversion and curing of the precursor, even of portions of the substrate that are geometrically shadowed from incident beam radiation. 1. A composite sheet comprising:a substrate having a first outer surface and an opposing second outer surface; and a metal layer overlaying the first outer surface of the substrate; and', 'an outer polymeric coating layer overlaying the metal layer and formed by curing a precursor that comprises a dual-function composition that includes an olefin group and a moisture-curable group., 'a multi-layer coating on the first outer surface of the substrate, the multi-layer coating comprising2. The composite sheet of claim 1 , wherein the olefin group is radically polymerizable.3. The composite sheet of claim 1 , wherein the precursor further comprises an acrylate or methacrylate composition.4. The composite sheet of claim 1 , wherein the moisture curable group is a moisture curable silane group.5. The composite sheet of claim 1 , wherein the metal layer consists essentially of aluminum.6. The composite sheet of claim 1 , wherein the emissivity of the metal layer is at most about 0.2. This invention relates to a method for effecting polymerization of an olefin and, more particularly, to a metalized, fibrous ...

DELIVERING A VIDEO STREAM

Delivering a video stream is disclosed. A request for the video stream is received. A past portion of the video stream is delivered to a client. The past portion has a marker time that precedes a current time by an interval that corresponds to a buffer length in a client buffer. Receiving a video stream is also disclosed. A request for the video stream is transmitted. A past portion of the video stream is received. The received past portion has a marker time that precedes a current time by an interval that corresponds to a buffer length in a client buffer. 1. A system , comprising: receive a request for a video stream;', 'deliver a past portion of the video stream to a client;', 'provide an indication of at least one of a marker time and a current time to the client, wherein the client is configured to play the past portion of the video stream according to the indication of the at least one of the marker time and the current time, and, 'a processor configured towherein the marker time precedes the current time by an interval; anda memory coupled to the processor and configured to provide the processor with instructions.2. The system of wherein the indication comprises a timestamp.3. The system of wherein the timestamp is delivered with the past portion of the video stream.4. The system of claim 3 , wherein the timestamp is encoded in the past portion of the video stream.5. The system of wherein the past portion of the video stream includes a frame having the marker time.6. The system of wherein the past portion of the video stream begins with the frame having the marker time.7. The system of wherein the client is configured to play the past portion of the video stream starting at the marker time.8. The system of wherein the indication is provided on a reoccurring basis.9. The system of wherein the indication is provided using a protocol used to synchronize a plurality of clients.10. The system of wherein the protocol comprises the Network Time Protocol (NTP).11. The ...

NOVEL HALOGEN-SUBSTITUTED COMPOUNDS

The invention relates inter alia to halogen-substituted compounds of the general formula (I) in which the substituents A, R-Rand Z-Zhave the meanings given in the description. Also described are processes for preparing the compounds of the formula (I) and possible intermediates for the preparation of these compounds. The compounds according to the invention are particularly suitable for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine. 2. The compound according to claim 1 , wherein Ais CH.3. The compound according to claim 1 , wherein Ais CH and Ris Cl.4. The compound according to claim 1 , wherein{'sub': '1', 'Zis 1-fluoro-cyclopropyl or 1-chloro-cyclopropyl;'}{'sub': 2', '3', '3', '2', '3', '3', '2', '2, 'Zis —S—CH, —SO—CH, —SO—CH, CF, CFH, Cl, Br, I or NO;'}{'sub': 3', '3, 'Zis CH.'}5. The compound according to claim 1 , wherein{'sub': '1', 'Zis 1-fluoro-cyclopropyl or 1-chloro-cyclopropyl;'}{'sub': 2', '3', '3', '2', '2, 'Zis —S—CH, Cl, Br, I, CF, CFH, or NO;'}{'sub': 3', '3, 'Zis CH.'}6. The compound according to claim 1 , wherein{'sub': '1', 'Zis 1-fluoro-cyclopropyl or 1-chloro-cyclopropyl;'}{'sub': 2', '3', '2', '2, 'Zis I, CF, CFH, or NO;'}{'sub': 3', '3, 'Zis CH.'}7. The compound according to claim 1 , wherein Ris H.8. The compound according to claim 1 , wherein Ais N.9. The compound according to claim 8 , wherein Ris Cl.10. A product comprising a compound of formula (I) according to for controlling insects claim 1 , arachnids and/o nematodes.11. A pharmaceutical composition comprising at least one compound according to .12. A medicament comprising a compound according to .13. A product comprising a compound according to for preparing a pharmaceutical composition for controlling parasites on animals.15. A product comprising a compound according to for protecting propagation material of plants. The present application relates to novel halogen-substituted compounds, to processes for their preparation and to ...

STIMULUS RESPONSIVE NANOPARTICLES

Disclosed are various embodiments of methods and systems related to stimulus responsive nanoparticles. In one embodiment includes a stimulus responsive nanoparticle system, the system includes a first electrode, a second electrode, and a plurality of elongated electro-responsive nanoparticles dispersed between the first and second electrodes, the plurality of electro-responsive nanorods configured to respond to an electric field established between the first and second electrodes. 113-. (canceled)14. A method for orienting an elongated electro-responsive nanoparticle within a dispersion fluid , comprising:establishing an electric field between a first electrode and a second electrode, the electric field extending through the dispersion fluid in proximity to the elongated electro-responsive nanoparticle; andresponsive to the established electric field, reorienting the elongated electro-responsive nanoparticle within the dispersion fluid.15. The method of claim 14 , wherein the elongated electro-responsive nanoparticle is rotated within the dispersion fluid by the established electric field.16. The method of claim 14 , wherein the elongated electro-responsive nanoparticle is translated within the dispersion fluid by the established electric field.17. The method of claim 14 , wherein the electric field is established by a voltage applied between the first and second electrodes.18. The method of claim 17 , further comprising deenergizing the voltage to relax the positioning of the elongated electro-responsive nanoparticle.19. A method of fabricating elongated electro-responsive nanoparticles claim 17 , the method comprising:filling an elongated electro-responsive nanoparticle template with reactive mesogen liquid crystal;curing the elongated electro-responsive nanoparticle template filled with reactive mesogen liquid crystal with UV light;etching away the elongated electro-responsive nanoparticle template; andseparating the elongated electro-responsive nanoparticles ...

POLYIMIDE WEB SEPARATOR FOR USE IN AN ELECTROCHEMICAL CELL

The present invention is directed to a separator for an electrochemical cell comprising a web, the web comprising fibers of a polyimide and a protective region wherein the protective region impedes electrochemical reduction of the polyimide inside the electrochemical cell. 1. A separator for an electrochemical cell , the separator comprising:(a) a web comprising fibers of a polyimide; and(b) a protective region wherein the protective region impedes electrochemical polyimide reduction.2. The separator of claim 1 , wherein the web is a nanoweb and the fibers are nanofibers wherein the nanofibers are characterized by a number average diameter in the range of one of: less than about 1000 nm claim 1 , from about 50 to about 800 nm claim 1 , or from about 100 to about 400 nm.3. The separator of claim 1 , wherein the polyimide is fully-aromatic.4. The separator of claim 3 , wherein the fully aromatic polyimide comprises:(a) at least one aromatic dianhydride as a monomer unit selected from the group consisting of pyromellitic dianhydride (PMDA), biphenyltetracarboxylic dianhydride (BPDA), and 3,3′,4,4′-benzophenone tetracarboxylic dianhydride (BTDA), and mixtures thereof; and(b) at least one diamine as a monomeric unit selected from the group consisting of oxydianiline (ODA), 1,3-bis(4-aminophenoxy)benzene (RODA), 1,4-phenelenediamine (PDA), and mixtures thereof.6. The separator of claim 1 , wherein the protective region comprises a coating on the fibers comprising:(a) particles of oxides of silicon, aluminum, calcium, or mixtures thereof, ranging from about 1 to about 20,000 nm, from about 1 to about 10,000 nm, or from about 1 to about 4,000 nm in diameter, and, optionally, a binder;(b) oxides of zirconium, tantalum, silicon, hafnium, or mixtures thereof;(c) silanes;(d) silsesquioxanes;{'sup': 1/2', '1/2, '(e) organic polymers characterized with a Hansen solubility parameter (δp) of at most about 19.2 MPaor at least about 23.2 MPa; or'}(f) mixtures thereof.7. The separator ...

VISCOELASTIC HYDROGELS WITH FAST STRESS RELAXATION

Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration. 1. A method of enhancing proliferation or differentiation of a cell , the method comprising contacting the cell with a fast-relaxing hydrogel , wherein the hydrogel is characterized by a fast stress relaxation rate (τ) , thereby enhancing proliferation or differentiation of a cell.2. The method of claim 1 , wherein the cell is a mesenchymal stem cell (MSC).3. The method of claim 2 , wherein the ability of the MSC to undergo osteogenic differentiation is enhanced as compared to the MSC that has been contacted with a hydrogel characterized by a slow stress relaxation rate (τ).4. The method of claim 1 , wherein the cell is encapsulated in the hydrogel.5. The method of claim 1 , wherein the hydrogel comprises a plurality of alginate polymer chains and a plurality of spacer molecules claim 1 , whereinthe plurality of alginate polymer chains are ionically cross-linked to each other; andwherein each of the plurality of spacer molecules comprises a first end and a second end, wherein the first end is attached to an alginate polymer chain and the second end is not attached to an alginate polymer chain.6. The method of claim 5 , wherein the spacer molecule is polyethylene glycol (PEG).7. The method of claim 5 , wherein the hydrogel further comprises a cell adhesive peptide.8. The method of claim 7 , wherein the cell adhesive peptide is attached to each of the plurality of alginate polymer chains.9. The hydrogel of claim 7 , wherein the cell adhesive peptide comprises an arginine-glycine-aspartate (RGD) amino acid sequence.10. The method of claim 1 , wherein the hydrogel is characterized by an initial modulus of about 11-30 kPa.11. The method of claim 1 , wherein the proliferation of the cell is enhanced by at least 1.5-fold as compared to proliferation of a cell that has been contacted with a hydrogel characterized by a slow stress ...

DISSIPATIVE SYSTEM FOR SAFETY GARMENTS

A system and overshoe for dissipating charge from a human body standing on a surface and wearing the system. The overshoe further contains a sole and an overshoe body that is attached to the edge of the sole such that the sole has an inner surface that faces the overshoe side and an outer surface that is exterior to the overshoe. A conductive strip is folded around at least a portion of the edge of the sole and bonded to the sole by a first adhesive such that at least a portion of the conductive strip is exposed to the inner surface of the sole. A tape covers the seam between the conductive strip and the sole on an exterior portion of the overshoe and that is adhesively bonded to the seam by a second adhesive such that at least a portion of the conductive strip is exposed to the surface that the human body is standing on. 1. A system for dissipating charge from a human body standing on a surface and wearing the system , said system comprising a dissipative overshoe , said overshoe further comprising;I. a sole,II. an overshoe body that is attached to the edge of the sole such that the sole has an inner surface that faces the overshoe side and an outer surface that is exterior to the overshoe,III. a conductive strip folded around at least a portion of the edge of the sole and bonded to the sole by a first adhesive such that at least a portion of the conductive strip is exposed to the inner surface of the sole,IV. a tape that covers the seam between the conductive strip and the sole on an exterior portion of the overshoe and that is adhesively bonded to the seam by a second adhesive such that at least a portion of the conductive strip is exposed to the surface that the human body is standing on;{'sup': 4', '8, 'wherein the portion that is exposed to the surface that the human body is standing on is sufficient in area to yield a resistance of in the range of >10to <10Ohm when measured between the hands of the human body and the surface.'}2. The system of in which the ...

HEAT EXHANGER

A heat exchanger, for example an intercooler or a coolant radiator, may include at least two floors each having a passage for accommodating a longitudinal end region of a plurality of fluid-conducting tubes. The heat exchanger may further include at least one side part having a longitudinal end region at least one of at least partially accommodated in a passage at an end of an associated floor and adjoining the associate floor. The at least one side part may include at least two segments having a different cross-section from one another. 1. A heat exchanger , comprising:at least two floors each having a passage for accommodating a longitudinal end region of a plurality of fluid-conducting tubes;at least one side part having a longitudinal end region at least one of at least partially accommodated in a passage at an end of an associated floor and adjoining the associated floor; andwherein the at least one side part includes at least two segments having a different cross-section from one another.2. The heat exchanger according to claim 1 , wherein the at least two segments of the at least one side part includes two substantially identical longitudinal end segments and a middle section arranged between the two longitudinal end segments.3. The heat exchanger according to claim 2 , wherein the middle section has at least one of a material thickness and a bending stiffness that is lower than the two longitudinal end segments.4. The heat exchanger according to claim 2 , wherein the middle section is structured as a metal strip.5. The heat exchanger according to claim 2 , wherein the two longitudinal end segments have at least one of a U-shaped cross-section claim 2 , a U-wedge shaped cross-section claim 2 , a L-shaped cross-section claim 2 , a W-shaped cross-section and a tubular cross-section with one or more chambers.6. The heat exchanger according to claim 2 , wherein a gap is provided between the middle section and at least one longitudinal end segment of the two ...

HEAT EXCHANGER WITH A CIRCUMFERENTIAL SEAL

A heat exchanger may include a plate, a seal and a cover. The plate may have at least two receiving grooves having a respective groove base, an intermediate region disposed in a plane between a plurality of rim holes, and a ramp extending between the intermediate region and the respective groove base of the at least two receiving grooves. The seal extends in the at least two receiving grooves. The ramp may be rounded at a transition to the receiving grooves with a first radius and at a transition to the intermediate region with a second radius, and the ramp may be inclined between 20°<α<65° relative to the intermediate region or has an S-shaped progression. An inflection point of the plate may be arranged in a region from 10% to 80% of a height difference between the intermediate region and the respective groove base. 1. A heat exchanger comprising: a plate , a seal and a cover ,the plate including at least two receiving grooves which are spaced apart in parallel and extend in a longitudinal direction of the plate, the at least two receiving grooves arranged on two mutually opposite sides of the plate and configured to receive a lateral projection of the cover,wherein the at least two receiving grooves have a respective groove base,wherein the plate has at least three rim holes arranged in a plane spaced apart from one another in parallel and spaced apart from the at least two receiving grooves, the at least three rim holes extending perpendicular to and between the at least two receiving grooves,an intermediate region disposed in the plane between at least two rim holes, wherein the intermediate region is arranged spaced apart from the respective groove base of the at least two receiving grooves in parallel by a height difference,at least two ramps respectively disposed between intermediate region and the respective groove bases, wherein the at least two ramps extend parallel to a longitudinal direction of the at least three rim holes and are spaced apart from one ...

POLYIMIDE WEB SEPARATOR FOR USE IN AN ELECTROCHEMICAL CELL

The present invention is directed to a separator for an electrochemical cell comprising a web, the web comprising fibers of a polyimide and a protective region wherein the protective region impedes electrochemical reduction of the polyimide inside the electrochemical cell. The present invention is further directed to a multi-layer article and electrochemical cell containing the separator. 1. A separator for an electrochemical cell , the separator comprising:(a) a web comprising fibers of a polyimide; and(b) a protective region wherein the protective region impedes electrochemical polyimide reduction.2. The separator of claim 1 , wherein the web is a nanoweb and the fibers are nanofibers wherein the nanofibers are characterized by a number average diameter in the range of one of: less than about 1000 nm claim 1 , from about 50 to about 800 nm claim 1 , or from about 100 to about 400 nm.3. The separator of claim 1 , wherein the polyimide is fully-aromatic.4. The separator of claim 3 , wherein the fully aromatic polyimide comprises:(a) at least one aromatic dianhydride as a monomer unit selected from the group consisting of pyromellitic dianhydride (PMDA), biphenyltetracarboxylic dianhydride (BPDA), and 3,3′,4,4′-benzophenone tetracarboxylic dianhydride (BTDA), and mixtures thereof; and(b) at least one diamine as a monomeric unit selected from the group consisting of oxydianiline (ODA), 1,3-bis(4-aminophenoxy)benzene (RODA), 1,4-phenelenediamine (PDA), and mixtures thereof.6. The separator of claim 1 , wherein the protective region comprises a coating on the fibers comprising:(a) particles of oxides of silicon, aluminum, calcium, or mixtures thereof, ranging from about 1 to about 20,000 nm, from about 1 to about 10,000 nm, or from about 1 to about 4,000 nm in diameter, and, optionally, a binder;(b) oxides of zirconium, tantalum, silicon, hafnium, or mixtures thereof;(c) silanes;(d) silsesquioxanes;{'sup': 1/2', '1/2, '(e) organic polymers characterized with a Hansen ...

Rail vehicle with pressure surge-safe graywater line

A rail vehicle includes a graywater line which is in communication with the surroundings of the rail vehicle directly or by way of a collecting container. The graywater line is equipped with a pressure protection valve, which protects a graywater line section upstream of the pressure protection valve from pressure surges occurring in the surroundings of the rail vehicle. The pressure protection valve is constructed as a pinch valve which is controlled by a control device in order to protect the graywater line section from pressure surges.

HALOGEN-SUBSTITUTED PYRAZOL DERIVATIVES AS PEST-CONTROL AGENTS

The invention relates inter alia to halogen-substituted compounds of the general formula (I) 7. A compound of formula (I) according to capable of being used for controlling one or more insects claim 1 , arachnids and/or nematodes.8. Pharmaceutical composition comprising at least one compound according to .9. Compound according to capable of being used as a medicament.10. A compound according to capable of being used for preparing one or more pharmaceutical compositions for controlling parasites on animals.11. Process for preparing a crop protection composition comprising mixing a compound according to and one or more customary extenders and/or surfactants.12. Method for controlling one or more pests claim 1 , comprising allowing a compound according to to act on the pests and/or a habitat thereof.13. A compound according to capable of being used for protecting propagation material of plants.14. Compound selected from:5-chloro-1-methyl-4-nitro-3-(pentafluoroethyl)-1H-pyrazole,1-methyl-4-(methylsulphanyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid,4-bromo-2′-methyl-4′-(methylsulphinyl)-5′-(trifluoromethyl)-2′H-1,3′-bipyrazole. The present application relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects, arachnids and nematodes.It is known that certain halogen-substituted compounds have herbicidal action (cf. J. Org. Chem. 1997, 62(17), 5908-5919, J. Heterocycl. Chem. 1998, 35(6), 1493-1499, WO 2004/035545, WO 2004/106324, US 2006/069132, WO 2008/029084).Furthermore, it is known that certain halogen-substituted compounds have insecticidal action (EP 1 911 751, WO2012/069366, WO2012/080376 & WO2012/107434).In addition, it is known that certain halogen-substituted compounds have cytokine-inhibitory activities (WO 2000/07980).Modern crop protection compositions have to meet many demands, for example in relation to efficacy, persistence and ...

Viscoelastic hydrogels with fast stress relaxation

Provided are fast relaxing hydrogels that are useful for regulating cell behavior and enhancing tissue regeneration, e.g., bone regeneration.

FACILITATING CLIENT DECISIONS

Facilitating a decision of a content player is disclosed. In some cases, performance information associated with a content player is received. The information is received from a client. A determination is made that an update should be sent to the client. The update is sent to the client. In other cases, information is received from an external entity. Based at least in part on the received information, an instruction is sent to a content player. 1. (canceled)2. A system , comprising: receive, from a first remote client, performance information associated with a first content player;', 'based at least in part on at least some of the performance information associated with the first content player, determine that at least one setting associated with obtaining content should be should be updated for a second remote client that is different from the first remote client; and', 'based at least in part on determining that the at least one setting should be updated for the second remote client, facilitate updating of the at least one setting for the second remote client; and, 'a processor configured toa memory coupled to the processor and configured to provide the processor with instructions.3. The system of wherein the processor is configured to determine claim 2 , based at least in part on the at least some of the performance information associated with the first content player claim 2 , a content distribution problem.4. The system of wherein the processor is configured to localize the content distribution problem to one or more of a content delivery network and an Internet service provider.5. The system of wherein the processor is further configured to determine that the second remote client is implicated in the content distribution problem claim 3 , and wherein facilitating updating of the at least one setting for the second remote client is based at least in part on the determination that the second remote client is implicated in the content distribution problem.6. The ...

Propenoyl-imidazole derivatives

Substituted triplets

System and method for multiplexed data back-up to a storage tape and restore operations using client identification tags

A system and method for backing up and restoring data from client computers at a server computer. The server computer receives back-up data from individual client computers and inserts them into a configurable buffer within a shared memory area. The server associates a client identification (ID) tag with each set of back-up data which identifies from which particular client computer the data was received. Buffer availability flags determine whether a buffer associated with a client server is full or available. The server multiplexes the back-up data and the identification tags onto a tape. Data from a particular client is de-multiplexed from the tape by scanning all of the identification tags on the tape and pulling off the tape any data-which is associated with the identification tag corresponding to the particular client. An additional back-up scheduler unit using configurable parameters enables the entire multiplexed data back-up process to be tailored to the performance capabilities of an individual set of client/server computer resources such as by limiting how many client computer back-up jobs may be written to a single tape drive.

Substituted 2-pyridones and pyrid-2-thiones processes for their preparation and their use in medicaments

For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula <IMAGE> in which A is optionally substituted aryl or heterocyclic, B is optionally substituted alkyl, cycloalkyl or aryl, D and E independently are optionally substituted aryl or heterocyclic, H, nitro, cyano, optionally substituted alkyl, alkenyl or imino, amino, alkoxy or acyl, or forms a ring with B, G is O or S, X is -CH2-CH2- or -CH=CH-, and R represents a group of the formula <IMAGE> and salts thereof. [US5032602A]

Copolymers based on unsaturated mono- or dicarboxylic acid derivatives and oxyalkylene glycol alkenyl ethers, process for their preparation and their use

The invention relates to copolymers which are based on mono or dicarboxylic acid derivatives, oxyalkylene glycol alkenyl ethers, vinyl polyalkylene glycol-, polysiloxane- or ester compounds in addition to the use thereof as additives for aqueous suspensions based on mineral or bituminous binding agents. The copolymers provide aqueous building material suspensions with excellent processing properties even in the smallest of doses without inhibiting resistance. The drastic reduction of the water/binding agent content achieved by the use of the inventive copolymers results in highly flowable building materials without any segregation of individual constituents in said building material mixture.

INJECTABLE, PORE-MAKING HYDROGLES FOR MATERIAL-BASED CELL THERAPIES

Compositions for surface treatments

A composition having at least one first component containing a perfluorinated aliphatic structure in which no more than six fluorine bearing carbons are connected in any single straight chain segment, in addition a group providing binding functionality to a surface to be treated or containing at least one polymerisable double bond or containing at least one cross-linkable group, and in addition a divalent radical containing at least one group capable of forming polar interactions or hydrogen bonds, and at least one second component containing a perfluorinated aliphatic structure in which no more than six fluorine bearing carbons are connected in any single straight chain segment and a moiety containing at least one group providing binding functionality to a surface to be treated or containing at least one polymerisable double bond or containing at least one cross-linkable group.

Alkoxymethyl-substituted pyridone biphenyls

SUBSTITUTED BIFENYLES.

Copolymers on the basis of unsaturated mono- or dicarboxylic acid derivatives and oxyalkylene glycol alkenyl ethers, processes for their preparation and use thereof

SUBSTITUTED 2-PYRIDONES AND PYRID-2-THIONES AND THEIR USE AS MEDICINES

Monitoring the performance of a content player

Monitoring performance data associated with a content player is disclosed. Information relating to the state of a content player is obtained on a time driven basis. At least a portion of the obtained information is reported, via a communications interface, to a content distribution monitoring server.

Non-contact freezing temperature determination

The present invention relates to a method for determining the freezing temperature of an ice-water mixture on a road surface, comprising: providing reference measurements of ice-to-water ratios in dependence on road temperatures for different salt contents of reference ice-water mixtures; detecting a thickness of a water layer on the road surface; detecting a thickness of an ice layer of the road surface; determining an ice- to-water ratio of the ice-water mixture from the detected thickness of the water layer and the detected thickness of the ice layer; detecting the temperature of the road surface; and determining the freezing temperature of the ice-water mixture from the determined ice-to- water ratio and the detected temperature by means of the provided reference measurements.

Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives, and pharmaceutical compositions thereof

IMIDAZOLYL SUBSTITUTED PHENYL ACIDANCE AMIDE

Process for producing substituted pyridyl dihydroxyheptanoic acids and their salts, as well as pharmaceutical compositions comprising same

Endless track conveyor

Halogen-substituted compounds

The invention relates inter alia to halogen-substituted compounds of the general formula (I) in which the radicals A 1 -A 4 , T, n, W, Q, R 1 and Z 1 -Z 3 have the meanings given in the description. Also described are processes for preparing the compounds of the formula (I). The compounds according to the invention are particularly suitable for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine.

Imidazolyl-propenoic acid derivatives

Imidazolyl-propenoic acid derivativeS A b s t r a c t Imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes with phosphonoacetic acid esters. The imidazolyl-propenoic acid derivatives are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments. Le A 28 591 - US

SUBSTITUTED PHENYLAMINOTHIAZOLE AND ITS USE

Method for producing metalized fibrous composite sheet with olefin coating

Monitoring the performance of a content player

Monitoring performance data associated with a content player is disclosed. Information relating to the state of a content player is obtained on a time driven basis. At least a portion of the obtained information is reported, via a communications interface, to a content distribution monitoring server.

Cyclic-substituted imidazolyl-propenoic acid derivatives.

Cyclically substituted 3,5-dicyano-2-thiopyridines and use thereof

The invention relates to novel 4-cycloalkyl- and 4-heterocycloalkyl-3,5-dicyano-2-thiopyridine derivatives, to a method for their production, to the use thereof for the treatment and/or prophylaxis of diseases and to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertonia and other cardiovascular diseases.

PROCESS FOR PREPARING SUBSTITUTED 2-PYRIDONE AND PYRID-2-THIONE

Die Erfindung betrifft Verfahren zur Herstellung substituierter 2-Pyridone und Pyrid-2-thione der allgemeinen Formel * in der die Substituenten A, B, D, G, E, X und R die in der Beschreibung angegebene Bedeutung haben. Die erfindungsgemaesz hergestellten Verbindungen koennen als Wirkstoffe in Arzneimitteln zur Behandlung von Hyperlipoproteinaemie, Lipoproteinaemie oder Ateriosklerose eingesetzt werden. Formel (I){2-Pyridone; Pyrid-2-thione-Herstellung; Pharmazeutika; Hyperlipoproteinaemie; Lipoproteinaemie; Arteriosklerose} The invention relates to processes for the preparation of substituted 2-pyridones and pyrid-2-thiones of the general formula * in which the substituents A, B, D, G, E, X and R have the meaning given in the description. The compounds prepared according to the invention can be used as active ingredients in medicaments for the treatment of hyperlipoproteinemia, lipoproteinemia or atherosclerosis. Formula (I) {2-pyridones; Pyrid-2-thiones production; pharmaceuticals; hyperlipoproteinemia; lipoproteinaemia; Arteriosclerosis}

Method for producing metalized fibrous composite sheet with olefin coating

A composite sheet is manufactured by depositing a multi-layer coating on the outer surface of a substrate, the coating comprising a metal layer and an outer polymeric layer formed from a precursor comprising a polymerizable composition that includes a olefin group and a moisture curable group, such as an isocyanate or silane group. After the precursor is applied, the composite sheet is exposed to both beam radiation and moisture, which respectively promote polymerization and curing at different sites of the precursor. The function of the cured polymeric layer includes protecting the metal layer from corrosion. The amenability of the isocyanate or silane functionality to moisture-promoted coupling promotes substantially full conversion and curing of the precursor, even of portions of the substrate that are geometrically shadowed from incident beam radiation.

Validator-controlled apparatus

Validator-controlled apparatus responsive to the inspection and validation of a plaque as genuine cooperating with a timer to control the power supply to and operation of a plurality of electrical components for one or consecutive predetermined periods. In an illustrative application of the apparatus, the validator inspects and authenticates a coded plaque of paper currency or a coded card as a prerequisite to the control and use of a room for a measured period of time equipped with one or more electrical components. One of the controlled components is a lock for the room door or barrier which re-locks after entrance of the patron or patrons and remains locked from its exterior but is manually releasable from the interior at any time. The apparatus includes provision for disabling the plaque validator and the door lock during the decrement of an existing predetermined time period.

Pentasubstituted phenyls

Substituted biphenyls can be prepared by reduction of appropriate ketones and, if appropriate, subsequent hydrolysis, cyclization, hydrogenation and separation of isomers. The substituted biphenyls can be used as active compounds in medicaments.

Bus-operated sensor device and corresponding test method

The present invention relates to a bus-operational sensor device (10), a sensor contact (50) and a device (150) that detects the state of the sensor contact and transmits the same to the control device (100). A switching element with a directional current/voltage characteristic (SE;D1) is configured in such a way that the sensor contact can be tested in a simple manner.

CONTROL SYSTEM FOR THE ELECTRIC FUEL PUMP OF AN INTERNAL COMBUSTION ENGINE

The proposal is for a control system for the electric fuel pump of an internal combustion engine with a rotation speed sensor (13) for a shaft of the engine and logic components (16a, 16b, 17) to prepare a switch-off signal for the pump depending on the detected speed, in which the signal from a further rotation speed sensor (14) is applied to the logic components (16, 17) and the pump is switched off only when both speed signals lie outside a predeterminable range. This ensures that the motor vehicle can still be driven if one of the sensors 13 or 14 becomes inoperative.

Method for producing metalized fibrous composite sheet with olefin coating

A composite sheet is manufactured by depositing a multi-layer coating on the outer surface of a substrate, the coating comprising a metal layer and an outer polymeric layer formed from a precursor comprising a composition capable of being polymerized and/or cross-linked by free-radical processes. After the precursor is applied, the composite sheet is exposed to beam radiation and ozone, which both promote conversion of the precursor. The function of the cured polymeric layer includes protecting the metal layer from corrosion. The use of both beam radiation and ozone promotes substantially full conversion and curing of the precursor, even in portions of the substrate that are geometrically shadowed from incident beam radiation.

Bus-operational sensor device and corresponding test method

The present invention relates to a bus-operational sensor device (10), a sensor contact (50) and a device (150) that detects the state of the sensor contact and transmits the same to the control device (100). A switching element with a directional current/voltage characteristic (SE;D1) is configured in such a way that the sensor contact can be tested in a simple manner.

Rail vehicle with pressure surge-safe graywater line

A rail vehicle includes a graywater line which is in communication with the surroundings of the rail vehicle directly or by way of a collecting container. The graywater line is equipped with a pressure protection valve, which protects a graywater line section upstream of the pressure protection valve from pressure surges occurring in the surroundings of the rail vehicle. The pressure protection valve is constructed as a pinch valve which is controlled by a control device in order to protect the graywater line section from pressure surges.

SHOCKING DEVICE FOR SPRING AND ABSORBING ACQUISITION OF SHOCKING FORCES.

The invention relates to a buffer gear for rail vehicles comprising two telescopically nesting countersprung housing sections (buffer sleeve 1 and buffer ram 2) and in the sleeve buffer a pressure cylinder (3), supported at one end against a housing section, with a plunger (4) protruding from the other end of the pressure cylinder (3) and supported against the other housing section, which plunger at its end extending into the cylinder carries a plunger head (4b), the pressure cylinder (3) being filled with a compressible elastomer (20). The object of the invention is to design the buffer gear so that its energy absorption can be accurately gauged by simple means, the static characteristic of which is insensitive and durable even under extreme stresses by virtue of suitably designed components, which can be built into any existing buffer. This object is achieved in that the pressure cylinder (3) has two elastomer chambers (15) and (16) separated by a guide ring (17) containing apertures, the cross section of a first elastomer chamber (15) receiving the plunger head (4b) matching the plunger head (4b) with a predefined degree of play and the second elastomer chamber (16) having a larger diameter. <IMAGE>

Isophthalic acid derivatives

The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.

Method for producing metalized fibrous composite sheet with olefin coating

A composite sheet is manufactured by depositing a multi-layer coating on the outer surface of a substrate, the coating comprising a metal layer and an outer polymeric layer formed from a precursor comprising a polymerizable composition that includes a olefin group and a moisture curable group, such as an isocyanate or silane group. After the precursor is applied, the composite sheet is exposed to both beam radiation and moisture, which respectively promote polymerization and curing at different sites of the precursor. The function of the cured polymeric layer includes protecting the metal layer from corrosion. The amenability of the isocyanate or silane functionality to moisture-promoted coupling promotes substantially full conversion and curing of the precursor, even of portions of the substrate that are geometrically shadowed from incident beam radiation.

HIGH-PRECISION ANGLE LOCATOR WITH PHOTOELECTRICALLY SCANNABLE TRACKS.

Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use

The invention relates to compounds of formula (I), to a method for their production and to the use of said compounds as medicaments.

METHOD FOR PRODUCING 2-ALKYL-3-CHLORPHENOLS

N-SUBSTITUTED N-AMINO-PYRROLES, THEIR PREPARATION AND USE

Substituted biphenyls

Injectable, pore-forming hydrogels for materials-based cell therapies

The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.

PROCESS FOR THE PREPARATION OF REPLACED PYRIDINES

Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives as angiotensin II antagonists

Bleaching solution for processing photographic silver halide materials, especially color reversal films, comprises an iron propylenediaminetetraacetic acid and beta-alaninediacetic acid complex

Bleaching or bleaching/fixing solution (I) for processing photographic silver halide materials in which at least 65 mole% of the silver is in elemental form after development comprises an iron propylenediaminetetraacetic acid (PDTA) complex and an iron beta -alaninediacetic acid (ADA) complex in an amount of 0.045-0.25 mole/l. Independent claims are also included for the following: (1) a method for processing color reversal silver halide materials comprising a bleaching step in which a solution of type (I) is used; (2) a composition for producing, regenerating or rejuvenating (I), where the composition can consist of one or more components and comprises essentially all of the necessary chemicals.

Injectable, pore-forming hydrogels for materials-based cell therapies

The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.

IMIDAZOLYL-propenoic acid derivatives

Heterocyclic substituted phenyl-cyclohexane-carboxylic acid derivatives

Contact material and process for its manufacture.

Contact material in the form of a layer of chalcogenides of transition metals of the groups IVa to VIa of the Periodic Table of Elements (PTE) on a substrate, the structure of the layer being modified by particle bombardment, and a process for the production of such a contact material.

Substituted mono- and bihydridylmethylpyridones

Process for producing pyrydilmethyl biphenyl derivatives and pharmaceutical preparations containing them

Road-grader.

Grinding wheel dressing system with pantograph - has cross slide mechanism actuating pantograph located above grinding wheel (NL140976)

The grinding wheel dressing system for a grinding machine with a disc shaped grinding wheel (14) rotating on a horizontal spindle (12) with two dressing diamonds (46, 48) mounted on a vertical spindle (40) and with a stepping motor (22) driving a pantograph system (16) located above, has two drive screws at right angles to each other carried in corresponding bushes (100, 102) at right angles supported by the frame (80) so as to operate the drive for the movement of the dressing diamonds. The arm of the pantograph drive can be connected for manual operation by contact with a stationery template, and can also be connected to a cross slide for automatic control using e.g. a punch card. The cross slides for the pantograph are mounted on a horizontal slide (18) above the grinding wheel drive.

STUFF FOR SELF-EMPLOYING RAILWAY WITH ROOF-BOTTOM

Method of obtaining substituted pyridil-dihydroxy-heptenic acid and its derivatives

Substituted pyridyldihydroxyheptenoic acid and its salts, optionally in an isomeric form, can be prepared, in the case of racemic products, by hydrolysing the corresponding racemic esters or, in the case of the stereoisomerically uniform products, by reacting the racemic esters with enantiomeric amines, separating the diastereomeric amides and then hydrolysing these amides. The products have very good pharmacological properties. They can be employed as HMG-CoA reductase inhibitors for the treatment of hyperlipoproteinaemia and arteriosclerosis.

RAIL WAGON

Imidazolyl-substituted amides of phenylacetic acid

Imidazolyl-substituted phenylacetamides of the general formula <IMAGE> in which A represents straight-chain or branched alkyl or alkenyl, each of which has up to 8 carbon atoms, or represents cycloalkyl having 3 to 8 carbon atoms, B represents hydrogen, halogen or perfluoroalkyl having up to 5 carbon atoms, D represents a group of the formula -CH2OR<3>, -CO-R<4>, -CO-NR<5>R<6>, <IMAGE> or <IMAGE>, E represents hydrogen, halogen, nitro, hydroxyl, trifluoromethyl, trifluoromethoxy, straight-chain or branched alkyl, alkoxy or alkoxycarbonyl, each of which has up to 6 carbon atoms, cyano or carboxyl, L represents straight-chain or branched alkyl having up to 8 carbon atoms which is optionally substituted by cycloalkyl having 3 to 8 carbon atoms or phenyl, or represents cycloalkyl having 3 to 12 carbon atoms which is optionally substituted by straight-chain or branched alkyl having up to 6 carbon atoms, R<1> represents hydrogen or straight-chain or branched alkyl having up to 8 carbon atoms, R<2> represents a radical of the formula -C(CH3)2-CH2OH, <IMAGE> and salts thereof. The compounds are angiotensin-II antagonists and can be used as active substances in pharmaceuticals, in particular for the treatment of hypertension and atherosclerosis.

SUBSTITUTE IMIDAZOLINONER OCH IMIDAZOLINTIONER.

SUBSTITUTED BIFENYL PYRIDONES

Discharging gate for railway self-discharging hopper car with sadle bottom

Process for producing substituted pyridine derivatives and pharmaceutical compositions containing them as active components

Facilitating client decisions

Facilitating a decision of a content player is disclosed. In some cases, performance information associated with a content player is received. The information is received from a client. A determination is made that an update should be sent to the client. The update is sent to the client. In other cases, information is received from an external entity. Based at least in part on the received information, an instruction is sent to a content player.

Biphenyl substituted spirotetronic acids and their use for the treatment of retroviral diseases

The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), where * is the carbon atom to which R1 and R2 are bonded, to processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.

SUBSTITUTED IMIDAZOLYL-PROPENSAEUREDERIVATE

Substituted imidazolyl-propenoic acid derivatives

Substituted imidazolyl-propenoic acid derivatives A b s t r a c t The substituted imidazolyl-propenoic acid derivatives can be prepared by reaction of the corresponding aldehydes with CH-acidic compounds and subsequent elimination of water. The substituted imidazolyl-propenoic acid derivatives can be employed as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments. Le A 28 592 - US

Injectable, pore-forming hydrogels for materials-based cell therapies

The invention provides compositions and methods to form pores in situ within hydrogels following hydrogel injection. Pores formed in situ via degradation of sacrificial porogens within the surrounding hydrogel facilitate recruitment or release of cells. Disclosed herein is a material that is not initially porous, but which becomes macroporous over time.

Substituted 1,8-naphthyridines

SUPPORT FOR REMOVING AND ABSORBING RECOVERY OF SHOCK CANCERS

Dynamic copolymers for workability retention of cementitious compositions

A process for the production of high early strength cementitious compositions includes mixing hydraulic cement, aggregate, water, and a slump retention admixture, wherein the slump retention admixture is a dynamic copolymer containing residues of at least the following monomers: A) a ethylenically unsaturated dicarboxylic acid, B) an ethylenically unsaturated alkenyl ether having an C2-4 oxyalkylene chain of about 1 to 25 units, C) an ethylenically unsaturated alkenyl ether having an C2-4 oxyalkylene chain of 26 to about 300 units, and D) an ethylenically unsaturated monomer comprising a moiety hydrolysable in the cementitious composition, wherein the monomer residue when hydrolyzed comprises an active binding site for a component of the cementitious composition. The present method is useful in the production of precast, ready mix, and/or highly filled cementitious compositions.

Method for selectively enabling or blocking the use of medical equipment

In a method for selectively enabling or blocking the use of medical equipment made available by a vendor or a system option in the medical equipment, for a customer, wherein the equipment is arranged in a facility of the customer, a compilation is created and stored at a vendor's computer from which it proceeds whether the customer is permitted to use the medical equipment overall or which system option of the medical equipment the customer is permitted to use. Given a desired utilization of the medical equipment or a system option of the medical equipment by the customer, a check is made at the vendor's computer as to see whether the customer is authorized for the use and whether costs arising from previous use are to be paid. The use is automatically enabled when the authorization still exists and no costs are outstanding, or the use is automatically inhibited when there is no authorization or costs are still outstanding.

Hygienic device