11-01-2018 дата публикации
Номер: US20180009796A1
Автор:
Berger Richard,
Blizzard Timothy A.,
CAMPBELL BRIAN T.,
Chen Helen Y.,
Debenham John S.,
Dewnani Sunita V.,
DuBois Byron,
Gude Candido,
GUO Zack Zhiqiang,
Harper Bart,
Hu Zhiyong,
LIN SONGNIAN,
Liu Ping,
Ujjainwalla Feroze,
Wang Ming,
Xu Jiayi,
Xu Libo,
Zhang Rui
Принадлежит:
The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity. 2. The compound of claim 1 , or pharmaceutically acceptable salt thereof claim 1 , wherein X is —N—.3. The compound of claim 1 , or pharmaceutically acceptable salt thereof claim 1 , wherein X is —CH—.4. The compound of claim 1 , or pharmaceutically acceptable salt thereof claim 1 , wherein Ris selected from the group consisting of isoxazole claim 1 , pyrazine claim 1 , oxadiazole and pyridazine claim 1 , wherein the isoxazole claim 1 , pyrazine claim 1 , oxadiazole or pyridazine is substituted with one or two substituents independently selected from the group consisting of C-Calkyl claim 1 , C-Calkene claim 1 , halogen claim 1 , halogen-substitutedC-Calkyl claim 1 , COOC-Calkyl claim 1 , CONH claim 1 , CONHC-Calkyl claim 1 , CON(C-Calkyl) claim 1 , CONHhalogen-substitutedC-Calkyl claim 1 , C-Calkoxy claim 1 , halogen-substitutedC-Calkoxy claim 1 , NHC-Calkyl claim 1 , C-Ccycloalkyl claim 1 , halogen-substitutedC-Ccycloalkyl claim 1 , —OH claim 1 , C-CalkylOH claim 1 , pyrrole claim 1 , phenyl claim 1 , halogen-substituted phenyl claim 1 , pyrazole claim 1 , N-methyl pyrazole claim 1 , pyrroline claim 1 , CO-pyrrolidine claim 1 , azetidine and CO-azetidine.5. The compound of claim 1 , or pharmaceutically acceptable salt thereof claim 1 , wherein Ris isoxazole claim 1 , wherein the isoxazole is substituted with one or two substituents independently selected from the group consisting of C-Calkyl claim 1 , C-Calkene claim 1 , halogen claim 1 , halogen-substitutedC-Calkyl claim 1 , COOC-Calkyl claim 1 , CONH claim 1 , CONHC-Calkyl claim 1 , CON(C-Calkyl) claim 1 , CONHhalogen-substitutedC-Calkyl claim 1 , C-Calkoxy claim 1 , halogen-substitutedC-Calkoxy claim 1 , NHC-Calkyl claim 1 , C-Ccycloalkyl claim 1 , halogen-substitutedC-Ccycloalkyl claim 1 , —OH claim 1 , C-CalkylOH claim 1 , pyrrole claim 1 ...
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