Piezoelectric driven linear motion device

The invention discloses a piezoelectric driven linear motion device, and relates to a piezoelectric driven motion device, so as to solve the problems that the existing linear driving device which uses single combination vibrator as the stator adopts a bearing as a supporting structure, the driving force is smaller, and the structure is complex. The piezoelectric driven linear motion device comprises an upper supporting frame, a lower supporting frame, a linear guide rail, a guide sleeve, two sets of pre-tightening mechanisms and two sets of stators; the two sets of the stators are respectively arranged on the upper supporting frame and the lower supporting frame; one end of the upper supporting frame is rotationally connected with one end of the lower supporting frame; the other end of the upper supporting frame is connected with the other end of the lower supporting frame through the two sets of the pre-tightening mechanisms; the guide sleeve is rotationally connected with one side of ...

Calibration device for six-dimensional force sensor

The invention relates to a calibration device, in particular to a calibration device for a six-dimensional force sensor, and aims to solve the problems of complex structure, tedious procedures, large size, difficulty in assembling and debugging, and unachievable independent loading of a single-dimensional force in all directions of an existing calibration device. A working platform of the calibration device for the six-dimensional force sensor is fixedly installed on the upper surface of a main body framework, a first upright post and a second upright post are parallelly arranged side by side on the upper surface of the working platform, a beam support component, the first upright post and the second upright post form a door-shaped framework, five pulleys are installed on the beam support component at equal intervals in a linear shape in the length direction of the beam support component, a sensor fixing flange is installed at the middle part of the upper surface of the working platform ...

Method for conjoint analysis of mobile network condition by using sweep generator and testing mobile phone

The invention discloses a method for conjoint analysis of a mobile network condition by using a sweep generator and a testing mobile phone. The method comprises the following steps of: (1) importing sweep generator drive test data and testing mobile phone drive test data; (2) preprocessing the sweep generator drive test data and the testing mobile phone drive test data respectively; (3) analyzing a mobile network scene; (4) performing conjoint analysis on the sweep generator drive test data and the testing mobile phone drive test data and outputting a summary report of neighbor cells of disparate systems in a whole network; and (5) outputting an analysis result and a suggestion on optimization. According to the method, a scene analysis result and a neighbor cell configuration suggestion are obtained by processing and analyzing the imported sweep generator drive test data and testing mobile phone drive test data, the two items of data are subjected to conjoint analysis, meanwhile, an analysis ...

Structure and major gene locus Psr9 of pod shattering resistance character of rape and application thereof

The invention discloses a structure and a major gene locus Psr9 of a pod shattering resistance character of a rape and application thereof. A preparation method of the major gene locus Psr9 of the pod shattering resistance character of the rape comprises the following steps of: (a) hybridizing by utilizing a high-low pod shattering resistance assembly zy72360 of the rape and R1, and carrying out selfing on an F1 generation to generate an F2 generation segregation population; (b) extracting a parent zy72360 and R1, the leaf total DNA of the F1 generation and F2 generation segregation population; (c) collecting rape SSR (Simple Sequence Repeat) label public databases, autonomously developing an SSR label, and screening polymorphic primers by utilizing the parent zy72360; (d) establishing a genetic map through distributions inside the F2 generation segregation population, carrying out QTL (Quantitative Trait Loci) locus analysis by dint of pod shattering resistance index data, and obtaining ...

Molecular marker of pot shattering resistance trait major gene locus of rapes and application

The invention discloses a molecular marker of a pot shattering resistance trait major gene locus of rapes and an application. The steps are as follows: 1) hybridizing double 11 variety and 73290 variety (which have obvious differences in the pot shattering resistance traits) in a cabbage type rape varieties, and carrying out selfing on progenies to obtain F2 and F2:3 segregation populations with the segregated pod shattering resistance traits; 2) carrying out polymorphic screening on parent DNA (deoxyribonucleic acid) by utilizing an SSR (simple sequence repeat) primer, and establishing a genetic linkage map by carrying out SSR molecular marker genotyping on the F2 progeny segregation populations; 3) carrying out field experiments and plant inquisition on the F2 and F2:3 segregation populations so as to obtain phenotype data of the pod shattering resistance traits; and 4) carrying out QTL (quantitative trait locus) detection by combining with the developed high-density molecular marker ...

Ballastless turnout slab, production process of ballastless turnout slab, ballastless turnout bed and ballastless turnout rail

The invention relates to a ballastless turnout slab, a production process of the ballastless turnout slab, a ballastless turnout bed and a ballastless turnout rail. The ballastless turnout slab comprises a turnout slab casing and a structural steel frame, wherein the turnout slab casing comprises a casing body 1 and a rail carrying table 2, the structural steel frame comprises a steel frame body 6 and a reinforced steel bar structure 7, and a grounding terminal 8 is arranged on the steel frame body 6. The production process of the ballastless turnout slab comprises the steps including sample placing, casting, maintenance and the like. The ballastless turnout bed comprises more than three turnout slab units and a point switch installing groove 14. The ballastless turnout rail comprises a steel rail system, a turnout bed, a concrete layer 15, a geotechnical cloth separation layer 16 and a base, wherein the steel rail system comprises a straight steel rail 17, a sharp rail 18, a buckle element ...

In-vitro spontaneous vicious transformation modeling technology of epithelial cells on surface of ovary of mouse

The invention discloses an in-vitro spontaneous vicious transformation modeling technology of epithelial cells on a surface of an ovary of a mouse. The technology comprises the following steps: firstly, determining in-vitro vicious transformation stages of the epithelial cells on the surface of the ovary of the mouse; then authenticating the in-vitro vicious transformation of the epithelial cells on the surface of the ovary of the mouse. The technical scheme provided by the invention provides a novel experimental model for better understanding characteristics in stages of vicious transformation of the epithelial cells on the surface of the ovary of the mouse and lucubrating the generation and development mechanism of epithelial cell ovarian cancer, and is helpful for searching for biomarkers for early diagnosis and preventing and treating effects of ovarian cancer.

Unit plate type ballastless track positioning intelligent monitor

The invention discloses a unit plate type ballastless track positioning intelligent monitor, which comprises a shell. A battery box, a wireless emitter, a pull cord type angle measuring device and a stress ring with a pull cord type displacement meter are disposed in the shell. One end of the stress ring is fixed on a fixing support, and the other end of the stress ring is fixed on a thrust plate of one side of the shell. The pull cord type angle measuring device and the pull cord type displacement meter are respectively connected with the wireless emitter and powered by the battery box. The bottom of the shell is provided with a positioning pin. The unit plate type ballastless track positioning intelligent monitor has the advantages of being capable of dynamically testing longitudinal stress borne by ballastless track plates and a change value of elevation between the two plates and sending test data information to a terminal, playing real-time intelligent monitoring and alarming roles ...

Pipeline robot for internal diameter measurement

The invention relates to a pipeline robot for internal diameter measurement. The pipeline robot for the internal diameter measurement comprises a supporting mechanism, a main driving mechanism and a laser measurement mechanism, wherein the supporting mechanism mainly consists of a nut for a ball screw, a step motor I, wheels, a connection rod, a push rod and the like; the main driving mechanism mainly consists of a worm gear, a worm rod, a belt wheel, a transmission belt and the like; and the linear movement of the pipeline robot can be realized through the driving of a step motor II. The laser measurement mechanism is mainly composed of a sensing measuring head, a sensor bracket and a step motor III. The pipeline robot provided by the invention can be used for measuring an internal diameter of a long pipeline, and can particularly meet the measurement requirement of thin and long pipes with the larger range of the internal diameter. The pipeline robot provided by the invention not only ...

Speed regulation protection device for alternating current electric hand drill

The invention discloses a speed regulation protection device for an alternating current electric hand drill. The device comprises a pushbutton switch and a sliding resistor. One end of the pushbutton switch is connected with one electrode of a power supply, and the other end of the pushbutton switch is divided into two branches, wherein one branch is connected with the T2 end of a silicon-controlled rectifier, and the other branch is connected with one end of the sliding resistor. The other end of the sliding resistor is connected in series with one end of a divider resistor. A trigger is arranged between the other end of the divider resistor and the G end of the silicon-controlled rectifier. The input end of a capacitor is connected with the other end of the divider resistor, and the output end of the capacitor is connected with the T1 end of the silicon-controlled rectifier, and then is connected with the electric hand drill which is connected with the other electrode of the power supply ...

Cross-beam-type six-dimensional force sensor with overload protection function

The invention provides a cross-beam-type six-dimensional force sensor with an overload protection function, relates to a six-dimensional force sensor, and aims to solve the problems that the conventional six-dimensional force sensor adopts a bolt way for achieving overload protection, so that the gap precision and the strength and the rigidity of the whole sensor after overload are difficultly guaranteed. Four inner beams and four overload protection beams are uniformly arranged along the outer wall of an inner ring in a staggered way; four outer beams are arranged on the outer sides of the four inner beams; the four outer beams are in one-to-one correspondence with the four inner beams; an outer ring is correspondingly arranged on the outer side of each overload protection beam; one outer beam is arranged between each two adjacent outer rings; the two ends of each outer beam are fixedly connected with the outer rings through connecting plates respectively; protection pins are in interference ...

Minimally invasive extension jib pedicle screw

The invention relates to a minimally invasive extension jib pedicle screw, which belongs to the field of medical equipment. The minimally invasive extension jib pedicle screw consists of a minimally invasive screw body (1), a minimally invasive extension jib connector (2), an opening press block (3) and a connecting screw plug (4), and is characterized in that the minimally invasive screw body (1) consists of a threaded part and a ball head part, is provided with a central through hole, the ball head part is provided with an internal hexagon, and the outer surface of the minimally invasive screw body (1) is provided with symmetrical flat surfaces; and the minimally invasive extension jib connector (2) is in a hollow structure, the left head part of the minimally invasive extension jib connector is provided with threads, the left head part of the minimally invasive extension jib connector is provided with spherical surfaces inside and outside, the surface of the minimally invasive extension ...

Continuous annealing process fault detection method based on recursive kernel principal component analysis

A fault detection method in a continuous annealing process based on a recursive kernel principal component analysis (RKPCA) is disclosed. The method includes: collecting data of the continuous annealing process including roll speed, current and tension of an entry loop (ELP); building a model using the RKPCA and updating the model, and calculating the eigenvectors {circumflex over (P)}. In the fault detection of the continuous annealing process, when the T2 statistic and SPE statistic are greater than their confidence limit, a fault is identified; on the contrary, the whole process is normal. The method mainly solves the nonlinear and time-varying problems of data, updates the model and calculates recursively the eigenvalues and eigenvectors of the training data covariance by the RKPCA. The results show that the method can not only greatly reduce false alarms, but also improve the accuracy of fault detection.

Realization method for gain correction and digital ALC of GSM digital fiber-optic repeater

The invention provides a realization method for gain correction and digital ALC (Automatic Level Control) of a GSM (Global System for Mobile Communications) digital fiber-optic repeater, which belongs to the field of telecommunication, has the advantages of high response speed and accuracy in control and flexibility and solves the problems in the prior art. In order to realize the purposes, the technical scheme adopted by the method is that a mid-frequency front-end gain correction module, a power statistics module, a threshold judgment and attenuation control module and a mid-frequency rear-end gain correction module are added in a digital mid-frequency processing unit.

CONTINUOUS ANNEALING PROCESS FAULT DETECTION METHOD BASED ON RECURSIVE KERNEL PRINCIPAL COMPONENT ANALYSIS

A fault detection method in a continuous annealing process based on a recursive kernel principal component analysis (RKPCA) is disclosed. The method includes: collecting data of the continuous annealing process including roll speed, current and tension of an entry loop (ELP); building a model using the RKPCA and updating the model, and calculating the eigenvectors {circumflex over (p)}. In the fault detection of the continuous annealing process, when the Tstatistic and SPE statistic are greater than their confidence limit, a fault is identified; on the contrary, the whole process is normal. The method mainly solves the nonlinear and time-varying problems of data, updates the model and calculates recursively the eigenvalues and eigenvectors of the training data covariance by the RKPCA. The results show that the method can not only greatly reduce false alarms, but also improve the accuracy of fault detection. 1. Field of the InventionThe present invention relates to a fault detection and diagnosis, more particular to a fault monitoring method of a continuous annealing process based on recursive kernel principal component analysis.2. The Prior ArtsWith increasing complexity of industrial processes, the requirement for reliability, availability and security is growing significantly. Fault detection and diagnosis (FDD) are becoming a major issue in industry. The actual production process has different characteristics, like linear, nonlinear, time-invariant, time-varying, etc. For the different production processes, we should use different fault monitoring methods so as to effectively monitor the fault. Continuous annealing process is a complex time-varying nonlinear process.For nonlinear characteristics of the industrial process, some scholars have proposed a kernel principal analysis (KPCA) method. KPCA projects nonlinear data to high-dimensional feature space by nonlinear kernel function, then performs a linear PCA feature extraction in the feature space. KPCA is to ...

Automatic cutter-feeding pipeline profiling groove tool device

The invention relates to an automatic cutter-feeding pipeline profiling groove tool device, comprising a profiling groove cutter holder assembly and a fixing stop block assembly, wherein the profiling groove cutter holder assembly is mounted at the front end face of the movable disc of a pipe cutting machine; and the fixing stop block assembly is mounted at the rear end face of a fixing base of the pipe cutting machine and is matched with the profiling groove cutter holder assembly to perform automatic cutting radial feeding motion at interval. The automatic cutter-feeding pipeline profiling groove tool device can be used as lathe accessories of a pipeline cutting machine, a groove cutter is a formed turning tool, and the edge shape can be grinded according to the welding grooves; and the automatic cutter-feeding pipeline profiling groove tool device can process U-shaped and J-shaped grooves to be suitable for various site needs, and can process precise welding grooves and consistent blunt ...

Meniscus transplanting bone bolt fixing technology and device

The invention relates to a meniscus transplanting bone bolt fixing technology and device and belongs to the field of medical devices. The meniscus transplanting bone bolt fixing device comprises two groups of components which are a group of bone bolts (bone bolt devices) for manufacturing standard sizes of allogenic meniscus front and rear angels and a group of bone tunnels (bone tunnel devices) for manufacturing the bone bolts for accommodating meniscus front and rear angles on a receptor tibial plateau. Each bone bolt device comprises a cone-shaped hollow drill (1) and a guide pin (2). Each bone tunnel device comprises an eccentric bone drill bit (3) and a drill bit (4). By X-rays and computed tomography (CT) scanning measurement, a donor which has the meniscus dimensions 10% larger than those of a receptor is selected, an allogenic inner side meniscus is made into front and rear angle dead point bone bolt belt completed meniscus on an operating table, and stitches which cannot be absorbed ...

Pressing connecting device of high-density printed board connector

The invention discloses a pressing connecting device of a high-density printed board connector. The pressing connecting device comprises a base and a protective cover. The protective cover is arranged on the base, a jack is arranged in the protective cover, a handle and a knob are arranged on the protective cover, stand columns are arranged on the two sides of the protective cover and fixedly connected to the base, and a movable beam, cushion blocks, springs, upper beams and gaskets are sequentially arranged on the stand columns. The movable beam is fixed on the stand columns through copper bushes, and the springs are fixed on the stand columns through the upper beams, the gaskets and nuts. The pressing connecting device especially meets pressing connection of a long pin connector, the double-stand-column gantry type structure is adopted, therefore, sliding lifting is stable and reliable, and rigid-flexible joint pressing force is achieved and even and uniform.

Multifunctional massager

The invention discloses a multifunctional massager which comprises two chest massager assemblies capable of being folded together, a vibration circuit assembly and a double-end integral love egg. Each chest massager assembly comprises a massager bottom shell and a massager surface shell, wherein the lower surface of the massager bottom shell is set into a shape suitable for covering a human chest, and a second containing space is formed between the massager bottom shell and the massager surface shell. The vibration circuit assembly comprises a power supply, a PCB and a plurality of motors, wherein output shafts of the motors are connected with eccentric wheels, and the vibration circuit assembly is contained in the second containing space. Grooves are formed in the two chest massager assemblies respectively. The double-end integral love egg comprises a connecting arm and love egg ends, wherein the two ends of the connecting arm are connected with the love egg ends respectively, and the ...

Meniscus transplanting bone bridge inlaying technology and device

The invention relates to a meniscus transplanting bone bridge inlaying technology and device and belongs to the field of medical devices. The meniscus transplanting bone bridge inlaying device is composed of a meniscus fixing table (1), a sighting device (2), a guide pin (3), a guide pin sleeve pipe (4), a drill bit sleeve pipe (5), a hollow drill (6), a semicircular bone chisel (7), a socket wrench (8), a drill bit (9) and an allen wrench (10). The meniscus transplanting bone bridge inlaying device is characterized in that a cutting edge is arranged at the left end of the hollow drill (6), a quick change interface is arranged at the right end of the hollow drill (6) and can be connected with a universal quick change handle, the center of the semicircular bone chisel (7) is provided with a through hole, a knife body is semicircular, the head of the semicircular bone chisel (7) is provided with a cutting edge, and the head of the socket wrench (8) is provided with the allen wrench. Under ...

Safe-use monitoring device for power fuse

The invention discloses a safe-use monitoring device for a power fuse. The safe-use monitoring device comprises a resistor and a capacitor, wherein the input terminal live wire of the fuse is connected in series with the capacitor and the resistor through a head-end diode and a head-end display lamp; the other end of the resistor is connected with a neutral wire; the output terminal live wire of the fuse is connected in series with the capacitor and the resistor through a tail-end diode and a tail-end display lamp; and the head-end display lamp and the tail-end display are both LEDs. The safe-use monitoring device can visually display whether the fuse is fused or not; and when follow-up equipment is powered off, a maintenance personnel can promptly judge whether the fuse is fused or the follow-up equipment goes wrong, so that the maintenance personnel can immediately take effective maintenance measures and the working efficiency is improved accordingly.

Coal powder combustion device for bone materials drying in asphalt stirring station

The invention discloses a coal powder combustion device for bone materials drying in an asphalt stirring station. The coal powder combustion device specifically comprises a structure size parameter and a combustion control parameter of an inner container of a coal powder combustor, wherein the structure size parameter specifically relates to a straight length, a semi-diameter, a front-end conical angle and a rear-end conical angle of the inner container of the coal powder combustor, and the number of the straight length, the semi-diameter, the front-end conical angle and the rear-end conical angle are sequentially as below: 1.6m-1.8m, 0.55m-0.65m, 50-60 degrees, and 15-20 degrees; the combustion control parameter is specifically as below: wind speeds of a primary, a secondary and a third wind ports are 20-30m/s, 50-60m/s and 40-50m/s; and wind temperatures are respectively 373K, 600K and 700K, the whirling strengths of the primary wind and the secondary wind are respectively 1 and 0.25- ...

Sulfonate fire retardation agents and preparation methods thereof

The present invention discloses a class of sulfonate fire retardation agents and preparation methods thereof, and relates to the technical field of synthesis of a class of sulfonate-containing fire retardation agents. A purposes of the present invention is to solve defects in the prior art, and provide a class of sulfonate fire retardation agents and preparation methods thereof. The sulfonate fire retardation agents have characteristics of no toxicity, droplet resistance, smoke suppression, high fire retardation efficiency, good thermal stability, low cost and simple process route, do not affect use performances, color and the like of products after being added to materials, and further form synergetic fire retardation effects with nitrogen. The sulfonate-containing fire retardation agents have the following structural formula, wherein R can be sulfonic group-containing fatty amine, an alcohol, sulfonic group-containing aromatic amine or phenol, and other substances. In addition, according ...

Rape stress resistance gene and application

The invention discloses a rape stress resistance gene and an application. The Brassica napus stress resistance gene DUF1645, a nucleotide sequence of the gene is shown as SEQ ID NO:1. Through over expression of Brassica napus stress resistance gene DUF1645 in arabidopsis thaliana, the invention found that the gene can greatly enhance the drought resistance and waterlogging tolerance of the plants, the plants enable normal growth in 15 days of drought stress or 10 days of waterlogging stress, and the yield and the quality are not influenced, the gene provides guarantee of yield enhancement of crops under drought and waterlogging adverse situation, so that the gene provided by the invention has good application prospect in breeding for stress tolerance of crops.

ANTIDIABETIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia. 3. The compound according to wherein T claim 1 , U claim 1 , V and W are CH; or a pharmaceutically acceptable salt thereof.5. The compound according to wherein A is —Ccycloheteroalkyl claim 1 , wherein each cycloheteroalkyl is unsubstituted or substituted with one claim 1 , two or three substituents selected from R; or a pharmaceutically acceptable salt thereof.10. The compound according to wherein Y is selected from: —O— claim 1 , —(CH)O— and —O—(CH) claim 1 , wherein CHis unsubstituted or substituted with one or two substituents selected from R; or a pharmaceutically acceptable salt thereof.11. The compound according to wherein Y is selected from: —O— claim 1 , —CH—O— claim 1 , and —O—CH— wherein CHis unsubstituted or substituted with one or two substituents selected from Calkyl; or a pharmaceutically acceptable salt thereof.12. The compound according to wherein Y is —(CH)O— claim 1 , wherein CHis unsubstituted or substituted with one or two substituents selected from R; or a pharmaceutically acceptable salt thereof.13. The compound according to wherein Y is selected from: —O— and —CH—O— claim 1 , wherein CHis unsubstituted or substituted with one or two substituents selected from Calkyl; or a pharmaceutically acceptable salt thereof.15. The compound according to wherein Z is —COH; or a pharmaceutically acceptable salt thereof.19. The compound according to wherein Ris —Ccycloalkyl claim 1 , ...

Hard safety protective tool capable of circularly rotating and applied to hydraulic climbing form technology

The invention discloses a hard safety protective tool capable of circularly rotating and applied to the hydraulic climbing form technology. The tool is used for climbing form periphery outer facade safety protection and comprises a steel plate, bar-shaped protrusions are arranged along the length direction of the steel plate abreast, circular holes are further uniformly distributed on the steel plate, the percentage of opening of the circular holes on the steel plate is 34%, the process of the steel plate is cold pressing cold rolling process, the pressed type steel plate with the percentage of opening of 34% forms the needed hard protective tool through the cold pressing cold rolling process, and the size of the steel plate, the aperture of the circular holes on the steel plate, intervals among the circular holes and the percentage of opening on the steel plate can be adjusted according to actual needs on the site. The hard safety protective tool is good in ventilation, firm, safe, less ...

Maintenance structure and maintenance method for plate-type ballastless track

The invention relates to a maintenance structure for a plate-type ballastless track. The maintenance structure comprises steel rails 1, fasteners 2, a track board 3, a maintenance filling layer 4, a CA (cement asphalt) mortar layer 5 and a jacking mechanism, wherein the steel rails 1 are fixed on the track board 3 through the fasteners 2; the maintenance filling layer 4 is arranged between the track board 3 and the CA mortar layer 5; the jacking mechanism comprises force-bearing components 6, fastening components 7 and jacking devices 8; the force-bearing components 6 are fixedly connected with the track board 3 through the fastening components 7; and the jacking devices 8 lift up the track board 3 through the force-bearing components 6. The invention also relates to a maintenance method for the plate-type ballastless track. The method comprises the main procedures of measuring a route, adjusting a longitudinal slope, jacking the track board, pouring quick set mortar under the board, finely ...

Rape respiration metabolism-related gene BnAOX1 and application thereof

The invention discloses rape respiration metabolism-related gene BnAOX1 and an application thereof. Gene expression difference screening experiments show that the expression level of the BnAOX1 gene in rape high-oil parents and high-oil F2 mixed populations is higher than that of low-oil parents and low-oil F2 mixed populations. A sequence of a rape genome homologous with the BnAOX1 gene is searched from a sequencing database according to an Arabidopis thaliana AOX1 gene sequence on an arabidopsis website and is spliced, and primers at two sides of the gene coding region sequence are designed. A parent zy036cDNA first strand is used as a template to carry out RT-PCR amplification, and the resulting amplified fragment is sequenced to obtain the BnAOX1 gene coding region sequence and mutant alleles or derivatives which are generated through adding, substituting, inserting or deleting one or more nucleotides. Transgene results with Arabidopis thaliana as an acceptor confirm that the over expression ...

Method for manufacturing sunflower low-fat pectins

The invention provides a method for manufacturing sunflower low-fat pectins. The method comprises the following steps: (1) taking crushed dry sunflower plates, soaking and rinsing the crushed dry sunflower plates, separating solid and liquid of the crushed dry sunflower plates and collecting filter cakes; (2) adding alcohol to the obtained filter cakes so as to soak the filter cakes, controlling the soaking temperature and time, separating the solid and liquid of the soaked filter cakes through solid-liquid separation equipment, and repeatedly enabling a filter liquor to be clear and transparent; (3) adding enzyme for enzymolysis: adding water to collected substances, adjusting the temperature and pH value of the collected substances, and adding a mixed enzyme to the collected substances; (4) adding water to the obtained filter cakes, heating the filter cakes, keeping the filter cakes for a period of time, and extracting pectins from the filter cakes; (5) carrying out alcohol precipitation ...

Device and system for adaptively adjusting pacing frequency

The invention provides a device and a system for adaptively adjusting pacing frequency. The device comprises a band-pass filter, an over-threshold value detecting and counting unit, a heart rate adaptation unit and a smooth transition unit, wherein the band-pass filter is used for performing band-pass filtering on an acceleration signal sensed by an acceleration transducer; the over-threshold value detecting and counting unit is used for acquiring an exercise intensity estimated value of a human body based on the filtered acceleration signal; the heart rate adaptation unit is used for acquiring a corresponding target heart rate according to a predefined adaptive curve based on the exercise intensity estimated value, wherein the adaptive curve consists of a sub-usual heart rate section which gradually ascends, a platform-shaped usual heart rate section, a super-usual heart rate section which gradually ascends, and a platform-shaped upper limit heart rate section; and the smooth transition ...

Multidirectional adjustable external radioulna fixing frame

The invention relates to a multidirectional adjustable external radioulna fixing frame, which belongs to the field of medical instruments and can be matched with bone nails for treating fracture of radioulna, fracture of metacarpal bones, fracture of wrist joints, fracture of cross wrist joints, and comminuted fracture. The multidirectional adjustable external radioulna fixing frame consists of nail clamping assemblies (1), frame bodies (2), eccentric shafts (3), a locking nut (4), a sphere (5), a connecting block (6), internal hexagon screws (7) and a back nut (8). The multidirectional adjustable external radioulna fixing frame is characterized in that the two ends of the connecting block (6) are arc-shaped, and a step hole and a through hole are formed in the middle part of the connecting block; a stepped through hole is formed in the center of the locking nut (4), and the left end of the locking nut is spherical, and the right end of the locking nut is provided with an internal thread ...

Technology for separating, culturing and identifying epithelial cells on mice ovary surface

The invention discloses a technology for separating, culturing and identifying epithelial cells on mice ovary surface, which comprises the following steps: separating and culturing epithelial cells on mice ovary surface; quantitively identifying purity of epithelial cells on mice ovary surface by an immunofluorescence method; detecting separating effect of epithelial cells on mice ovary surface by an immunohistochemistry method. The invention provides a better method for separating, culturing and identifying epithelial cells on mice ovary surface, thereby providing an experiment model for better understanding vicious conversion characteristics of epithelial cells on mice ovary surface, and providing a new experiment means for better researching aetiological agent and generation development mechanism of epithelial cell ovarian cancer, and the invention is good for further searching early stage screening index of ovarian cancer.

Large-volume concrete beneficial for controlling temperature and shrinkage crack and construction process thereof

The invention relates to a large-volume concrete beneficial for controlling temperature and shrinkage crack and the construction process thereof. The large-volume concrete is as follows: the weight ratio of cement, coarse aggregate, fine aggregate and water is 1.3-3.5 to 2-2.3 to 0.45-0.55; and the construction method comprises the following steps: (1) trial preparing; (2) testing cube compressive strength of concrete; (3) mixing concrete raw materials according to selected materials for trail preparation and components in the mixing ratio; (4) for the concrete, using a casting method for casting at fixed point in a sectional way, casting with one slope, casting in a thin layer, gradually advancing and casting the top at one time, and using a secondary vibrating method, wherein three vibrating gas concretes are placed in front of, in the middle of and behind each concrete layer; (5) covering a plastic film and/or covering a 1 cm thick gunny bag on the concrete after the concrete is finally ...

Multi-functional bone spicule wrench

The invention relates to a multi-functional bone spicule wrench and belongs to the field of medical instruments. The multi-functional bone spicule wrench is suitable for orthopedics external fixation and internal fixation operations. The multi-functional bone spicule wrench is composed of a handle (1), a rod (2), a nut (3), a pawl locking piece (4), springs (5), a threaded pin (6), a ratchet wheel sleeve (7), a three-jaw outer sleeve (8), a three-jaw screw (9), an inner sandwich (10), a claw (11), a pin (12), a core sleeve (13) and a ball (14). The multi-functional bone spicule wrench is characterized in that the core sleeve (13) is step-shaped, outer threads are arranged at the right end of the core sleeve (13), a through hole is formed in the center of the core sleeve (13), and threads are arranged at two ends of the core sleeve (13); a stepped through hole and a taper hole are formed in the center of the inner sandwich (10), and the outer surface of the inner sandwich (10) is taper-shaped ...

Fiber winding apparatus and winding molding method thereof

The invention relates to a fiber winding apparatus and a winding molding method thereof. The fiber winding apparatus comprises a first work table, a second work table, a third work table, a fiber tension control mechanism and a yarn unfolding mechanism, wherein the fiber tension control mechanism comprises an alternating current servo motor and a work-piece, the alternating current servo motor is arranged on the first work table, and is connected with a rotary support for supporting and fixing the first work table, the work-piece is fixed on the first work table, and the alternating current servo motor drives the work-piece to rotate. The fiber winding apparatus is characterized in that a rotation vertical column is fixed on a fixed distance position, a horizontal straight line guide rail is fixed on the rotation vertical column, the second work table and the third work table are arranged on the horizontal straight line guide rail, and positions of the second work table and the third work ...

Cross-shaped beam type elastomer for six-dimensional force sensor

The invention relates to an elastomer for a six-dimensional force sensor, and provides a cross-shaped beam type elastomer for the six-dimensional force sensor to solve the problems of low sensibility and large coupling among dimensions of the existing elastomer for the six-dimensional force sensor. Four inner beams and four overload protection beams are uniformly distributed and staggered along an outer wall of an inner ring, four outer beams are arranged on the outer sides of the four inner beams, the four outer beams and the four inner beams are in one-to-one correspondence, the outer beams are fixedly connected with the corresponding inner beams, an outer ring is correspondingly arranged on the outer side of each overload protection beam, one outer beam is arranged between every two adjacent outer rings, and each of the two ends of the outer beam is fixedly connected with one outer ring through a connecting plate, two outer ring through holes are formed in the upper end surface and the ...

Growth adjustable one-way nail

The invention relates to a growth adjustable one-way nail, belongs to the field of medical instrument, and is applied to an orthopedic surgery. The growth adjustable one-way nail is composed of a growing cap ring (1), an inner hexagonal screw plug (2), an elastic pressing block (3) and a growth screw body (4), and is characterized in that the center of the grow cap ring (1) is provided with a through hole, and the right end of the grow cap ring (1) is provided with an opening; threads are placed on the outer surface of the inner hexagonal screw plug (2), a through hole is placed in the center of the inner hexagonal screw plug (2), and the left end of the inner hexagonal screw plug (2) is provided with an inner hexagonal hole; the center of the elastic pressing block (3) is provided with a through hole, the surface of the elastic pressing block (3) is provided with steps, the right end of the elastic pressing block (3) is provided with a through groove, and the left end of the elastic pressing ...

Base station database inspection method based on Drools rule engine

The invention discloses a base station database inspection method based on a Drools rule engine. The method is characterized by utilizing the Drools rule engine to separate program modification processing and business inspection logic. The method includes the following steps: 1) dividing base station data inspection condition into two scenes, respectively a single table inspection scene and an intersection inspection scene; 2) determining a field model for base station data inspection; 3) conducting field inspection according to different scenes and controlling the drools rule engine through the business inspection logic, conducting inspection processing according to an inspection rule description file and feeding an inspection result to the program modification processing to conduct interface display to enable the user to conduct modification. The base station database inspection method based on the Drools rule engine utilizes the rule engine to separate the business logic and coding, ...

Substituted cycloproply compounds, compositions containing such compounds and methods of treatment

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

ISOQUINOLINE DERIVATIVES AS MGAT2 INHIBITORS

The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity. 2. The compound of claim 1 , or pharmaceutically acceptable salt thereof claim 1 , wherein X is —N—.3. The compound of claim 1 , or pharmaceutically acceptable salt thereof claim 1 , wherein X is —CH—.4. The compound of claim 1 , or pharmaceutically acceptable salt thereof claim 1 , wherein Ris selected from the group consisting of isoxazole claim 1 , pyrazine claim 1 , oxadiazole and pyridazine claim 1 , wherein the isoxazole claim 1 , pyrazine claim 1 , oxadiazole or pyridazine is substituted with one or two substituents independently selected from the group consisting of C-Calkyl claim 1 , C-Calkene claim 1 , halogen claim 1 , halogen-substitutedC-Calkyl claim 1 , COOC-Calkyl claim 1 , CONH claim 1 , CONHC-Calkyl claim 1 , CON(C-Calkyl) claim 1 , CONHhalogen-substitutedC-Calkyl claim 1 , C-Calkoxy claim 1 , halogen-substitutedC-Calkoxy claim 1 , NHC-Calkyl claim 1 , C-Ccycloalkyl claim 1 , halogen-substitutedC-Ccycloalkyl claim 1 , —OH claim 1 , C-CalkylOH claim 1 , pyrrole claim 1 , phenyl claim 1 , halogen-substituted phenyl claim 1 , pyrazole claim 1 , N-methyl pyrazole claim 1 , pyrroline claim 1 , CO-pyrrolidine claim 1 , azetidine and CO-azetidine.5. The compound of claim 1 , or pharmaceutically acceptable salt thereof claim 1 , wherein Ris isoxazole claim 1 , wherein the isoxazole is substituted with one or two substituents independently selected from the group consisting of C-Calkyl claim 1 , C-Calkene claim 1 , halogen claim 1 , halogen-substitutedC-Calkyl claim 1 , COOC-Calkyl claim 1 , CONH claim 1 , CONHC-Calkyl claim 1 , CON(C-Calkyl) claim 1 , CONHhalogen-substitutedC-Calkyl claim 1 , C-Calkoxy claim 1 , halogen-substitutedC-Calkoxy claim 1 , NHC-Calkyl claim 1 , C-Ccycloalkyl claim 1 , halogen-substitutedC-Ccycloalkyl claim 1 , —OH claim 1 , C-CalkylOH claim 1 , pyrrole claim 1 ...

Casting Design Advisor Toolkit

A system for providing casting design advisement for designing a cast component is provided. The system includes an integrated design environment, the integrated design environment receiving a concept design for the cast component, the concept design being user-modifiable. The system also includes a plurality of design advisory modules, the plurality of design advisory modules determining physics models associated with the concept design for the cast component and providing advisement analysis for the concept design based on the physics models. The system includes a design rule logic solver for receiving concept design features associated with the concept design and comparing the concept design features with stored casting design rules to determine a geometry modification guide.

SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included. 3. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein ring A is pyridyl.4. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein ring A is phenyl.5. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein B represents (b) COR claim 1 , wherein Ris{'sub': '1-6', 'Calkyl, or'}{'sub': '3-6', 'Ccycloalkyl,'}wherein the alkyl and cycloalkyl are optionally substituted with 1-3 substituents independently selected from:halogen,{'sub': '1-6', 'Calkyl,'}{'sub': '3-6', 'or Ccycloalkyl.'}6. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein B is pyrimidine claim 1 , optionally substituted with 1-3 substituents independently selected from:halogen;hydroxyl;{'sub': '1-6', 'Calkyl;'}{'sub': '1-6', 'C(O)OCalkyl;'}C═O;CN;{'sub': '1-6', 'Calkoxy;'}{'sub': '3-6', 'Ccycloalkyl;'}{'sub': n', '1-6, 'C(═O)—(O)—R′, wherein n is an integer from 0-3 and R′ is Calkyl or H;'}5-6 membered heteroaryl ring containing 1-4 heteroatoms independently selected from nitrogen or oxygen;{'sup': f', 'f, 'C(═O)—R, wherein Ris a 5-6 membered heteroaryl ring containing 1-4 heteroatoms independently selected from nitrogen or oxygen;'}{'sub': '1-6', 'or haloCalkoxy;'}wherein the alkyl moiety is optionally substituted with 1-3 substituents independently selected from:halogen,hydroxy,{'sub': '1-6', 'Calkyl, or'}{'sub': '1-6', 'Calkoxy.'}7. The compound of or a pharmaceutically acceptable salt thereof claim 1 , wherein B is 1 claim 1 ,2 claim 1 ,4-oxadiazol optionally substituted with 1-3 substituents independently selected from{'sub': '1-6', 'Calkyl;'}{'sub': '1-6', ' ...

Antidiabetic bicyclic compounds

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia Formula (I).

Wall-hung bracket for projection screen

A wall-hung bracket for a projection screen is provided, including a guide rail, a slider and a lead screw. The guide rail is configured for being fixed on a wall along a vertical direction. The slider is slidingly connected to the guide rail. The slider is configured for being connected to a rear surface of a projection screen. The lead screw is provided with threads, and the lead screw is in threaded connection to the slider. When the lead screw rotates on its longitudinal axis, the slider slides in the vertical direction along the guide rail driven by the lead screw.

SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS

Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included 2. The compound of claim 1 , wherein ring A is pyridinyl claim 1 , pyrimidinyl claim 1 , pyridazinyl claim 1 , pyrazinyl claim 1 , triazinyl claim 1 , or phenyl.3. The compound of claim 2 , wherein ring A is pyridinyl claim 2 , pyrimidinyl claim 2 , or phenyl.4. The compound of claim 3 , wherein ring A is phenyl.5. The compound of claim 1 , wherein ring B is pyridinyl claim 1 , pyrimidinyl claim 1 , pyridazinyl claim 1 , pyrazinyl claim 1 , or triazinyl.6. The compound of claim 5 , wherein ring B is pyridinyl or pyrimidinyl.7. The compound of claim 6 , wherein ring B is pyrimidinyl.12. The compound of claim 1 , wherein the cyclopropyl ring of formula I is the cis cyclopropyl isomer.13. The compound of claim 12 , wherein the cyclopropyl ring of formula I has the 1S and 2R stereocenters.14. The compound of claim 13 , or a pharmaceutically acceptable salt thereof claim 13 , wherein the compound is present in at least 90% diastereomeric excess.15. The compound of claim 1 , wherein ring A is phenyl; and ring B is pyrimidinyl.24. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier.2527-. (canceled)28. A method for the treatment of a condition selected from the group consisting of obesity and diabetes comprising administering to an individual a pharmaceutical composition comprising the compound of . The present invention relates to G-protein coupled receptor agonists. In particular, the present invention is directed to agonists of GPR 119 that are useful for the treatment of diabetes, especially type 2 diabetes, as well as ...

TRICYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS

The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, where-in R, R, R, R, R, Rand n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject. 2. The compound of wherein each Ris halo claim 1 , or a pharmaceutically acceptable salt thereof.3. The compound of or wherein Ris hydrogen claim 1 , or a pharmaceutically acceptable salt thereof.4. The compound of any of to wherein Ris hydrogen claim 1 , or a pharmaceutically acceptable salt thereof.5. The compound of any of to wherein Ris hydrogen or methyl claim 1 , or a pharmaceutically acceptable salt thereof.6. The compound of any of to wherein Ris hydrogen claim 1 , or a pharmaceutically acceptable salt thereof.7. The compound of any of to wherein Ris hydrogen claim 1 , methyl claim 1 , ethyl claim 1 , CHOCHor phenyl claim 1 , or a pharmaceutically acceptable salt thereof.8. The compound of any of to wherein Ris methyl claim 1 , ethyl or CHCHOCH claim 1 , or a pharmaceutically acceptable salt thereof.9. The compound of any of to wherein Rand Rcan be taken together with the carbon atom to which they are attached to form a 5-membered heterocyclyl group claim 1 , or a pharmaceutically acceptable salt thereof.10. The compound of any of to wherein Rand Rcan be taken together with the carbon atom to which they are attached to form a tetrahydrofuranyl group claim 1 , or a pharmaceutically acceptable salt thereof.11. The compound of any of to wherein Rand Rcan be taken together with the atoms between them to form a 6-membered heterocyclyl group claim 1 , or a pharmaceutically acceptable salt thereof.12. The compound of any of to wherein Rand Rcan be taken together with the atoms between them to form a morpholinyl group claim 1 , or a pharmaceutically ...

Lobed track pin

A track pin may comprise a body that includes a generally cylindrical configuration defining an axis of rotation, a circumferential direction and a radial direction, the body defining a first end, a second end and a peripheral surface extending from the first end to the second end. The peripheral surface may include a first lobed portion spaced axially away from the first end and the second end and including a series of convex arcuate segments and concave arcuate segments joined to each other tangentially, forming an undulating surface.

SENSOR

Disclosed is a sensor, comprising: a housing; a detecting element provided inside the housing; a first cylinder provided inside the housing and sleeved outside the detecting element, the first cylinder having an amount of elastic deformation in a direction intersecting a surface around the detecting element; a particle filler, for filling an inner cavity of the housing. When external environment produces mechanical shock to the sensor or the sensor produces mechanical vibration, the limiting action of the first cylinder and the particle filler enables the detecting element to only have very little vibration displacement or even no vibration displacement with respect to the housing. The external mechanical shock can be partially or completely absorbed by the first cylinder and the particle filler, so as to reduce vibration displacement of the detecting element caused by the shock. 123-. (canceled)24. A sensor , comprisinga housing;a detecting element, provided inside the housing;a first cylinder, provided inside the housing and sleeved outside the detecting element, the first cylinder having an amount of elastic deformation in a direction intersecting a surface around the detecting element;a particle filler, for filling an inner cavity of the housing.25. The sensor according to claim 24 , wherein claim 24 , the first cylinder has at least one through-hole provided thereon.26. The sensor according to claim 25 , wherein claim 25 , the first cylinder has a recessed region in a radially inward direction; the recessed region is sleeved on the detecting element claim 25 , and the through-hole is formed in the recessed region.27. The sensor according to claim 26 , wherein claim 26 , the recessed region comprises claim 26 , along an axial direction of the first cylinder claim 26 , a straight first segment and a first flared segment flaring outward from one open end of the first segment claim 26 , the first segment fitting closely on the detecting element.28. The sensor ...

Tricyclic heterocycle compounds useful as hiv integrase inhibitors

The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Respiratory metabolism-associated gene bnaox1 from brassica napus and use thereof

The sequences of the AOX1 gene and protein from Brassica napus are provided. The use of AOX1 gene to increase seed oil content and thousand kernel weight in plants is also provided..

Substituted cyclopropyl compounds useful as GPR119 agonists

Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

Isoquinoline derivatives as mgat2 inhibitors

Isoquinoline derivatives as MGAT2 inhibitors

The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.

Substituted cyclopropyl compounds useful as gpr119 agonists

Chromane amidine monobactam compounds for the treatment of bacterial infections

The present invention relates to monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formula I or a pharmaceutically acceptable salt therof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of structural formula I, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Chromane amidine monobactam compounds for the treatment of bacterial infections

The present invention relates to monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of structural formula I, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Chromane amidine monobactam compounds for the treatment of bacterial infections

The present invention relates to monobactam compounds of Formula (I):(Formula (I)) and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of structural formula I, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Temperature control device and temperature control method

A temperature control device and a temperature control method are provided. The temperature control device is located at an interface between a photoresist coating and developing machine and a lithography machine and includes: a temperature detection device, a gas flow generator and a controller. The temperature detection device and the gas flow generator are respectively connected to the controller. The temperature detection device is configured to detect an actual temperature at the interface in real time. The gas flow generator is at least configured to generate a gas flow sealing knife around the interface. The controller is configured to control the gas flow generator to generate the gas flow sealing knife responsive to that the actual temperature detected by the temperature detection device is not equal to the target temperature, to control the actual temperature at the interface to reach the target temperature through the gas flow sealing knife.

Chromane amidine monobactam compounds for the treatment of bacterial infections

The present invention relates to monobactam compounds of Formula (I):(Formula (I)) and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of structural formula I, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Tricyclic heterocycle compounds useful as HIV integrase inhibitors

The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Lobed track pin

A track pin may comprise a body (316) that includes a generally cylindrical configuration defining an axis of rotation (A), a circumferential direction (C) and a radial direction (R), the body defining a first end (328), a second end (330) and a peripheral surface (318) extending from the first end (328) to the second end (330). The peripheral surface (318) may include a first lobed portion (314) spaced axially away from the first end (328) and the second end (330) and including a series of convex arcuate segments (308) and concave arcuate segments (332) joined to each other tangentially, forming an undulating surface.

Lobed track pin

Lobed track pin

Pasador de oruga lobada.

Un pasador de oruga puede comprender un cuerpo que incluye una configuración generalmente cilíndrica que define un eje de rotación (A), una dirección circunferencial (C) y una dirección radial (R), el cuerpo define un primer extremo, un segundo extremo y una superficie periférica que se extiende desde el primer extremo hasta el segundo extremo. La superficie periférica puede incluir una primera porción lobulada separada axialmente del primer extremo y el segundo extremo e incluye una serie de segmentos arqueados convexos y segmentos arqueados cóncavos unidos entre sí tangencialmente, formando una superficie ondulada.

Pasador de oruga lobulado

Un pasador (300, 300', 300", 300'") de oruga para su uso con una cadena (200, 702) de oruga de un vehículo (700) que incluye una pluralidad de pasadores (300, 300', 300", 300'") y casquillos (210, 600) de oruga, comprendiendo el pasador (300, 300', 300", 300'") de oruga: un cuerpo (316) que incluye una configuración generalmente cilíndrica que define un eje de rotación (A), una dirección circunferencial (C) y una dirección radial (R), definiendo el cuerpo (316) un primer extremo (328), un segundo extremo (330) y una superficie periférica (318) que se extiende del primer extremo (328) al segundo extremo (330), incluyendo la superficie periférica (318) una primera parte lobulada (314) separada axialmente del primer extremo (328) y el segundo extremo (330) y que incluye una serie de segmentos (308) arqueados convexos y segmentos (332) arqueados cóncavos unidos de forma tangencial entre sí, formando una superficie ondulada.

Lobed track pin

A track pin may comprise a body (316) that includes a generally cylindrical configuration defining an axis of rotation (A), a circumferential direction (C) and a radial direction (R), the body defining a first end (328), a second end (330) and a peripheral surface (318) extending from the first end (328) to the second end (330). The peripheral surface (318) may include a first lobed portion (314) spaced axially away from the first end (328) and the second end (330) and including a series of convex arcuate segments (308) and concave arcuate segments (332) joined to each other tangentially, forming an undulating surface.

Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment

Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included

Lobed track pin

A track pin may comprise a body (316) that includes a generally cylindrical configuration defining an axis of rotation (A), a circumferential direction (C) and a radial direction (R), the body defining a first end (328), a second end (330) and a peripheral surface (318) extending from the first end (328) to the second end (330). The peripheral surface (318) may include a first lobed portion (314) spaced axially away from the first end (328) and the second end (330) and including a series of convex arcuate segments (308) and concave arcuate segments (332) joined to each other tangentially, forming an undulating surface.

Chromane amidine monobactam antibiotics

The present invention relates to monobactam compounds of Formula I: The present invention also relates to pharmaceutical compositions comprising a monobactam compound of structural formula I or a pharmaceutically acceptable salt thereof. The invention further relates to the compounds of formula (I) for use in methods for treating a bacterial infection, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic. The present invention discloses the synthesis and characterisation of exemplary compounds as well as biological assays thereof. An exemplary compound is e.g.(S)-2-((((Z)-l-(2-aminothiazol-4- yl)-2-(((S)-2,2-dimethyl-4-oxo-l-(sulfooxy)azetidin-3-yl)amino) -2-oxoethylidene)amino)oxy)-2-((R)-6-(N-((S)-pyrrolidin-3-yl) carbamimidoyl)chroman-2-yl)propanoic acid (example 7; compound 1):

Pet cage

Pet cage

Chromane amidine monobactam antibiotics

The present invention relates to monobactam compounds of Formula I: The present invention also relates to pharmaceutical compositions comprising a monobactam compound of structural formula I or a pharmaceutically acceptable salt thereof. The invention further relates to the compounds of formula (I) for use in methods for treating a bacterial infection, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic. The present invention discloses the synthesis and characterisation of exemplary compounds as well as biological assays thereof. An exemplary compound is e.g.(S)-2-((((Z)-l-(2-aminothiazol-4- yl)-2-(((S)-2,2-dimethyl-4-oxo-l-(sulfooxy)azetidin-3-yl)amino) -2-oxoethylidene)amino)oxy)-2-((R)-6-(N-((S)-pyrrolidin-3-yl) carbamimidoyl)chroman-2-yl)propanoic acid (example 7; compound 1):

Tricyclic heterocycle compounds useful as hiv integrase inhibitors

The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Antidiabetic bicyclic compounds

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia Formula (I).

Protective enclosure, energy-storage apparatus, and electricity-consumption device

A protective enclosure, an energy-storage apparatus, and an electricity-consumption device are provided in the present disclosure. The protective enclosure includes a main housing and a heat-conducting member. The main housing defines a heat-conducting hole. The heat-conducting hole extends through the main housing in a thickness direction of the main housing. The heat-conducting member is mounted at an inner side of the main housing, is integrated with the main housing, and covers the heat-conducting hole. According to the technical scheme of the present disclosure, heat dissipation efficiency of the energy-storage apparatus can be improved, service life of the energy-storage apparatus can be prolonged, and use reliability of the electricity-consumption device can be improved.

Flower bud differentiation promoter for crops

The invention relates to a crop flower-bud differentiation promoter, which consists of urea, zinc sulfate, borax, calcium superphosphate, ferrous sulfate, potassium sulfate, rice vinegar and water, the mixture ratio is: 5-20% of urea, 5-15% of zinc sulfate, 20-30% of borax, 5-10% of calcium superphosphate, 5-15% of ferrous sulfate, 10-15% of potassium sulfate, 0.5-1% of rice vinegar and a proper amount of water .After adopting the above structure, the invention has the following advantages: foliar fertilization by mixed medicaments can timely supplement the nutrition needed by crops, effectively prevent premature senescence of crops, inhibit diseases and increase yield; foliar fertilization is fast in absorption, can make up for the deficiency of slow effect of soil fertilization, relieve the element deficiency disease of crops in time, use less fertilizer, improve fertilizer efficiency, and is safe and pollution-free. 1

Battery post

Crop florescence prolonging-agent and preparation method thereof

The invention relates to a crop florescence prolonging-agent and a preparation method thereof, which comprises amino acids, vitamins, low molecular sugar, inorganic salts, plant growth regulators, antifreeze, chlorophyllin, ethyl pyruvate, water and 9-cis-epoxycarotenoid dioxygenase, piperonal, Trichoderma and Bacillus. The invention has the following advantages:adding amino acids, vitamins, low molecular sugar, inorganic salts, chlorophyllin, ethyl pyruvate, water and 9-cis-epoxycarotenoid dioxygenase, plant growth regulator for prolonging florescence and antifreeze can achieve the functions of antifreeze, self-repair and prolonging florescence of plants in production, so that it makes plants healthier and more ornamental and can reduce diseases and insect pests. 1

Protective Enclosure, Energy-Storage Apparatus, and Electricity-Consumption Device

A protective enclosure, an energy-storage apparatus, and an electricity-consumption device are provided. The protective enclosure includes a main housing and a heat-conducting member. The main housing defines a heat-conducting hole. The heat-conducting hole extends through the main housing in a thickness direction of the main housing. The heat-conducting member is mounted at an inner side of the main housing, is integrated with the main housing, and covers the heat-conducting hole.

Compuestos monobactámicos de cromano amidina para tratar las infecciones bacterianas

La presente invención se refiere a compuestos monobactámicos de fórmula (1), y sus sales farmacéuticamente aceptables. La presente invención también se refiere a composiciones que comprenden un compuesto monobactámico de fórmula estructural (1) o una de sus sales farmacéuticamente aceptables y un vehículo farmacéuticamente aceptable. La invención también se refiere a métodos para tratar una infección bacteriana que comprende administrar al paciente una cantidad terapéuticamente eficaz de un compuesto de fórmula estructural (1), ya sea solo o en combinación con una cantidad terapéuticamente eficaz de un segundo antibiótico betalactámico.

Antibióticos monobactámicos de amidina cromano

La presente invención se refiere a compuestos monobactámicos de fórmula I: , (I) y sus sales farmacéuticamente aceptables. La presente invención también se refiere a composiciones que comprenden un compuesto monobactámico de fórmula estructural I o una de sus sales farmacéuticamente aceptables y un vehículo farmacéuticamente aceptable. La invención también se refiere a métodos para tratar una infección bacteriana que comprende administrar al paciente una cantidad terapéuticamente eficaz de un compuesto de fórmula estructural I, ya sea solo o en combinación con una cantidad terapéuticamente eficaz de un segundo antibiótico beta-lactámico.

Compuestos monobactámicos de cromano amidina para tratar las infecciones bacterianas

La presente invención se refiere a compuestos monobactámicos de fórmula I: , (I) y sus sales farmacéuticamente aceptables. La presente invención también se refiere a composiciones que comprenden un compuesto monobactámico de fórmula estructural I o una de sus sales farmacéuticamente aceptables y un vehículo farmacéuticamente aceptable. La invención también se refiere a métodos para tratar una infección bacteriana que comprende administrar al paciente una cantidad terapéuticamente eficaz de un compuesto de fórmula estructural I, ya sea solo o en combinación con una cantidad terapéuticamente eficaz de un segundo antibiótico beta-lactámico.

Antibioticos monobactamicos de cromano amidina.

La presente invención se refiere a compuestos monobactámicos de Fórmula I: (ver Fórmula) (I) la presente invención también se refiere a composiciones farmacéuticas que comprenden un compuesto monobactámico de fórmula estructural I o una sal farmacéuticamente aceptable del mismo. La invención se refiere además a los compuestos de fórmula (I) para usarse en métodos para tratar una infección bacteriana, ya sea solos o en combinación con una cantidad terapéuticamente efectiva de un segundo antibiótico beta-lactámico. La presente invención divulga la síntesis y caracterización de compuestos ejemplares así como ensayos biológicos de los mismos. Un compuesto ejemplar es, por ejemplo, ácido (S)-2-((((Z)-1(2-aminotiazol-4-il)-2-(((S)-2,2-dime til-4-oxo-1-(sulfooxi)azetidin-3-il)amino-2-oxoetilideno)amino)ox y)-2-((R)-6-(N((S)-pirrolidin-3-il) carbamimidoil)croman-2-il)prop anoico (ejemplo 7; compuesto 1): (ver Fórmula).

Compuestos monobactamicos de cromano amidina para tratar las infecciones bacterianas

La presente invencion se refiere a compuestos monobactamicos de formula (I) y sus sales farmaceuticamente aceptables, a composiciones que comprenden un compuesto monobactamico de formula estructural (I) o una de sus sales farmaceuticamente aceptables y un vehiculo farmaceuticamente aceptable. La invencion tambien se refiere a metodos para tratar una infeccion bacteriana. En particular, se refiere a un compuesto de Formula (I) o una de sus sales farmaceuticamente aceptables, en donde: T es CH o N, con la condicion de que no mas de dos de T, U y V son N; U es CH o N; V es CH o N; X se selecciona entre O y CH2; Y esta seleccionado entre O, NR8, S y CH2, con la condicion de que cuando Y es O, NR8 o S entonces X no es O; Z es O, S, CH2 o NH, con la condicion de que cuando Z es O, S o NH, entonces X no es O; W se selecciona entre enlace y O; Q se selecciona entre N y CR8; R1 se selecciona entre -cicloalquilo C3-12, -cicloalquenilo C3-12, -cicloheteroalquilo C2-11, entre otros; R2 se selecciona entre H, -alquilo C1-6, -alquil C1-6-OR4 y -alquil C1-6-NHR4; R3 se selecciona entre H y OH; R4 se selecciona entre H, alquilo C1-3 y cicloalquilo C3; R5 se selecciona entre -CO2H y tetrazol; R6 y R7 se seleccionan entre H y alquilo C1-6; R8 se selecciona independientemente entre H, alquilo C1-4, halogeno y cicloalquilo C3-7; R9 y R10 se seleccionan entre H y alquilo C1-6; cada Rb es H, -alquilo C1-6, -alquil C0-6-O-alquilo C1-6, entre otros; cada Rc es H, -alquilo C1-6, -alquil C0-6-O-alquilo C1-6, entre otros.

Compuestos monobactámicos de cromano amidina para tratar las infecciones bacterianas

La presente invención se refiere a compuestos monobactámicos de fórmula I: , [IMÁGEN] (I) y sus sales farmacéuticamente aceptables. La presente invención también se refiere a composiciones que comprenden un compuesto monobactámico de fórmula estructural I o una de sus sales farmacéuticamente aceptables y un vehículo farmacéuticamente aceptable. La invención también se refiere a métodos para tratar una infección bacteriana que comprende administrar al paciente una cantidad terapéuticamente eficaz de un compuesto de fórmula estructural I, ya sea solo o en combinación con una cantidad terapéuticamente eficaz de un segundo antibiótico beta-lactámico.

Tricyclic heterocycle compounds useful as hiv integrase inhibitors

Chromane amidine monobactam antibiotics

The present invention relates to monobactam compounds of Formula I: The present invention also relates to pharmaceutical compositions comprising a monobactam compound of structural formula I or a pharmaceutically acceptable salt thereof. The invention further relates to the compounds of formula (I) for use in methods for treating a bacterial infection, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic. The present invention discloses the synthesis and characterisation of exemplary compounds as well as biological assays thereof. An exemplary compound is e.g.(S)-2-((((Z)-l-(2-aminothiazol-4- yl)-2-(((S)-2,2-dimethyl-4-oxo-l-(sulfooxy)azetidin-3-yl)amino) -2-oxoethylidene)amino)oxy)-2-((R)-6-(N-((S)-pyrrolidin-3-yl) carbamimidoyl)chroman-2-yl)propanoic acid (example 7; compound 1):