05-06-2014 дата публикации
Номер: US20140155367A1
Автор:
Bollu Venkatataiah,
Chatterjee Arnab Kumar,
Kondreddi Ravinder Reddy,
Leong Seh Yong,
Mishra Pranab Kumar,
Moreau Robert Joseph,
Nagle Advait Suresh,
Paraselli Prasuna,
Roland Jason Thomas,
Sim Wei Lin Sandra,
Simon Oliver,
Tan Liying Jocelyn,
Yeung Bryan KS,
Zou Bin
Принадлежит:
The present invention provides compounds of formula I: 2. The compound of claim 1 , wherein L is selected from the group consisting of *—C(O)N(R)— claim 1 , and *—N(R)C(O)— claim 1 , wherein each Ris independently selected from hydrogen claim 1 , Calkyl claim 1 , and R—Calkylene claim 1 , and wherein R is selected from the group consisting of Cheterocycloalkyl and Cheteroaryl claim 1 , each of which is unsubstituted or substituted with 1-2 substituents independently selected from the group consisting of halo claim 1 , amino claim 1 , hydroxyl claim 1 , Calkyl claim 1 , Calkoxy claim 1 , oxo claim 1 , and Cheteroaryl.3. The compound of claim 1 , wherein L is selected from the group consisting of *—CH(CH)— claim 1 , *—CHCH— claim 1 , *—CHN(CH)— claim 1 , *—CHN(C(O)(CH)NH(CH))— claim 1 , *—CHN(C(O)—(CH)NH)— claim 1 , *—CHN((C(O)—(CH)N(CH))— claim 1 , *—CHN(C(O)(CH)OH)— claim 1 , *—CH(CH)N(CH)— claim 1 , *—CHO— claim 1 , *—CHS— claim 1 , *—CHS(O)— claim 1 , *—C(O)— claim 1 , *—C(O)N(CH)— claim 1 , *—C(O)N(CHCH)— claim 1 , *—C(O)N(CH(CH))— claim 1 , *—C(O)N(C(CH))— claim 1 , *—C(O)N(CHCH(CH))— claim 1 , *—C(O)N(CH(CH)CHCH)— claim 1 , *—C(O)N(CHCHOCH)— claim 1 , *—C(O)N(CHCHN(CH))— claim 1 , *—C(O)N(CH)CH— claim 1 , *—NHCH— claim 1 , *—N(CH)CH— claim 1 , *—N(CH-tetrahydropyran-4-yl)-C(O)— claim 1 ,*—N(CH)C(O)— claim 1 , *—N(CH)C(O)NH— claim 1 , *—N(CH)S(O)— claim 1 , *—C(O)N((CH)-cyclopropyl)- claim 1 , *—C(O)N((CH)-cyclobutyl)- claim 1 , *—C(O)N((CH)-cyclopentyl)- claim 1 , *—C(O)N((CH)-cyclohexyl)- claim 1 , *—C(O)N(CH-tetrahydropyran-4-yl)- claim 1 , *—C(O)N((CH)-(1 claim 1 ,1-dioxidothiomorpholino-4-yl))- claim 1 , *—C(O)N(CH-1 claim 1 ,1-dioxidothiomorpholino-4-yl)- claim 1 , *—C(O)N((CH)-tetrahydropyran-4-yl)) claim 1 , *—C(O)N((CH)-morpholin-4-yl)- claim 1 , *—C(O)N(oxetan-3-yl)- claim 1 , *—C(O)N(CH-oxetan-3-yl)- claim 1 , *—C(O)N(CH(CH)—CH-1-H-pyrazoly-1-yl)- claim 1 , *—CHN(C(O)—(CH)-morpholinyl))- claim 1 , *—CHN(C(O)—(CH)-4-methylpiperizin-1-yl)) claim 1 , *— ...
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