An improved bin for household use

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium to an outlet chamber located at one end of the piston channel. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position, the piston chamber volume is reduced and pressure within the piston chamber increases to a point where the pressure moves the valve member into an open position. When the valve member is in the open position, medium from the piston chamber is discharged into an outlet chamber located on the opposite side of the coil relative to the armature. An outlet is provided in flow communication with the outlet chamber, for discharging infusion medium from the outlet chamber.

Infusion device and driving mechanism and process for same with actuator for multiple infusion uses

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. The armature may be configured with a reduced diameter by including a coil cup for supporting the coil including a shelf portion defining at least a portion of a pole surface of the coil cup.

Wakeword detection

Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may initially include an untrained wakeword detection component. The wakeword detection component of the DSP may be trained by engaging a user to speak particular utterances. Once a companion application is configured to implement a wakeword detection component, the companion application's wakeword detection component may be trained specific to the user of the device. Once the companion application's wakeword detection component is trained, the DSP wakeword detection component may be deactivated or its accuracy adjusted.

Wakeword detection

Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may initially include an untrained wakeword detection component. The wakeword detection component of the DSP may be trained by engaging a user to speak particular utterances. Once a companion application is configured to implement a wakeword detection component, the companion application's wakeword detection component may be trained specific to the user of the device. Once the companion application's wakeword detection component is trained, the DSP wakeword detection component may be deactivated or its accuracy adjusted.

Infusion device and driving mechanism and process for same with actuator for multiple infusion uses

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. The armature may be configured with a reduced diameter by including a coil cup for supporting the coil including a shelf portion defining at least a portion of a pole surface of the coil cup.

Inflatable restraint apparatus

An inflatable restraint apparatus for an automotive vehicle includes an air bag deployment door formed in a trim panel. The air bag deployment door outer surface has an area of 5 in2to 35 in2, and at least a portion of the perimeter comprises a frangible marginal edge. The frangible marginal edge includes a frangible length, and at least 20% of the frangible length is non-linear. The apparatus also includes an air bag dispenser containing an air bag having a volume of at least 90 liters. The air bag dispenser includes an elongated container having an air bag receptacle containing an air bag and an inflator receptacle containing an inflator.

Wakeword detection

Techniques for processing input data for a detected user are described. Received image data is processed to identify an indicated user. Based on the user a machine learning model is implemented. The machine learning model is then used to process input data for a user input. An action is performed using the resulting output data.

Wakeword detection

Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. If the DSP's wakeword detection component detects a wakeword in speech, the companion application's wakeword detection component may be used to determine whether the wakeword was spoken by the user of the device. If the companion application's wakeword detection component determines the user spoke the wakeword, audio data representing the speech may be sent to at least one server(s) for processing.

Restorative Cleaning Process

The present invention is a deep cleaning process for carpets through its unique restorative cleaning process. The present comprises a use of restorative cleaning agent and cleansers according to the pH level of the stain, and a method either of agitating with hand-held polyester carpet brush or of rotary power scrubbing with polyester brush. Through its unique deep cleaning process including anti-ghost stain treatment to prevent the stain from re-appearing, the present invention will yield cleaner cleaning process than the industry standard cleaning method. In an alternative embodiment of the Restorative Cleaning Process of the present invention, man-made carpet fibers are cleaned using a series of cleaning steps designed to extract soil particulates from the fibers of the carpet and decrease the time it takes for the carpet to dry. In addition, an anti-reappearing ghost spot device utilizing the anti-reappearing ghost spot post-treatment is used to prevent spots from re-appearing.

Systems and methods for providing airflow in an aerospace vehicle

Systems and methods for providing airflow in an aerospace vehicle are disclosed. A system in accordance with one embodiment includes an aerospace vehicle having an interior volume with a first portion and a second portion. The system can further include an external air supply device positioned to provide supply air to the interior volume at a variable supply flow rate and a recirculation fan configured to move air positioned within the interior volume between the first portion of the interior volume and the second portion of the interior volume. The system can still further include a controller operably coupled to the recirculation fan and configured to vary a rotation speed of the recirculation fan. Variations in the rotation speed of the recirculation fan can be associated with variations in a recirculation flow rate. In selected embodiments, the system can include sensors and/or data link devices operably coupled to the controller.

Novel acylalkylisethionate esters and applications in consumer products

The present invention provides acylalkylisethionate esters useful in consumer products. The acylalkylisethionate esters are produced by reacting one or more carboxylic acids with one or more alkyl-substituted hydroxyalkyl sulfonates under esterification reaction conditions. The alkyl-substituted hydroxyalkyl sulfonates used as a raw material in producing the esters are prepared by reacting bisulfite with one or more alkylene oxides.

Electronic control system and process for electromagnetic pump

An electronic control systems and process for infusion devices and pump configurations can provide highly efficient use of electrical power. The system may include a capacitor which is controlled to partially, but not fully discharge, to provide a power pulse to a pump coil. In this manner, the capacitor remains partially charged and need not be re-charged from a fully discharged state. In addition, the power applied to the coil in a given discharge pulse signal may be controlled to correspond to the power needs of the pump, by controlling the degree to which the capacitor is discharged to produce the pulse signal. A power cut-off switch may be provided to control the discharge of the capacitor such that the capacitor is stopped from discharging prior to the actual end of the armature stroke. The time at which the capacitor discharge is stopped may be selected such that energy remaining in the coil after the capacitor stops discharging is sufficient to continue the pump stroke to the actual end of the stroke. The time at which the capacitor discharge is cut off may be based on the location of the armature in its stroke motion. A power disconnect switch may be provided between the capacitor and the battery, to allow the capacitor to be electrically disconnected from the battery during storage or other periods of non-use, to avoid losing battery power due to the inherent leakage of the capacitor during prolonged periods of non-use.

Methods and compositions for regulating cell death and enhancing disease resistance to plant pathogens

Compositions and methods for enhancing disease resistance to a pathogen in a plant are provided. Methods of the invention comprise stably transforming a plant with an antisense nucleotide sequence for a gene encoding an enzyme in the C-5 porphyrin metabolic pathway and operably linking said antisense sequence to a pathogen-inducible promoter, such that invasion of a cell by a pathogen elicits a hypersensitive-like response that results in confinement of the pathogen to cells of initial contact. Transformed plants and seeds are provided. Nucleotide sequences encoding a wild-type maize urod gene useful in the present invention and the amino acid sequence for the protein encoded thereby are provided. These compositions are also useful for regulating cell death in specifically targeted tissues. A maize lesion mimic, dominant mutant phenotype, designated Les22, and the molecular basis for its manifestation are also provided.

ELECTRODE INCLUDING A MULTI-REGION CURRENT COLLECTOR

An electrochemical cell is provided that includes a current collector plate and a pellet. The current collector plate includes a circumferential outer peripheral wall and an inner wall coupled thereto, where the circumferential outer peripheral wall defines a cavity and has a height, and the inner wall extends across and physically separates the cavity into at least two regions and has a height that is less than the height of the circumferential outer peripheral wall. The pellet comprises active powder material and is disposed in the cavity and circumferentially surrounded by and in contact with the circumferential outer peripheral wall of the current collector plate. The pellet includes a first portion and second portion, where the first portion is disposed in a first region of the at least two regions and the second portion is disposed in a second region of the at least two regions.

Device for indicating the ' hits' upon a rifle target

Electronic control system and process for electromagnetic pump

An electronic control systems and process for infusion devices and pump configurations can provide highly efficient use of electrical power. The system may include a capacitor which is controlled to partially, but not fully discharge, to provide a power pulse to a pump coil. In this manner, the capacitor remains partially charged and need not be re-charged from a fully discharged state. In addition, the power applied to the coil in a given discharge pulse signal may be controlled to correspond to the power needs of the pump, by controlling the degree to which the capacitor is discharged to produce the pulse signal. A power cut-off switch may be provided to control the discharge of the capacitor such that the capacitor is stopped from discharging prior to the actual end of the armature stroke. The time at which the capacitor discharge is stopped may be selected such that energy remaining in the coil after the capacitor stops discharging is sufficient to continue the pump stroke to the actual ...

WAKEWORD DETECTION

Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. If the DSP's wakeword detection component detects a wakeword in speech, the companion application's wakeword detection component may be used to determine whether the wakeword was spoken by the user of the device. If the companion application's wakeword detection component determines the user spoke the wakeword, audio data representing the speech may be sent to at least one server(s) for processing.

SWAY BAR BUSHING BRACKET WITH TOW HOOK

Currently, some work vehicles and/or off-road vehicles come from the manufacturer lacking tow hooks—or even a strong point on the rear bumper assembly and/or the chassis to install a tow hook. A non-limiting example of this sort of vehicle is the Toyota Tundra. It is highly desirable for such a vehicle to be able to be towed by another vehicle and/or have connection points for recovery from stuck in a natural hazard like mud or water. A novel and improved sway bar bushing bracket with a tow hook design is disclosed. In particular, the manufacturer-installed sway bar bushing bracket may be replaced with a reinforced sway bar bushing bracket with an integrated tow hook that may serve as a more robust sway bar bushing bracket, as well as providing a strong connection point with a tow hook.

Pre-weakening of fabric covered airbag doors

A variety of embodiments are disclosed, in both apparatus and method form, that relate to the use of fabric material in the manufacture of an air bag deployment system. In addition, fabric weakening is disclosed according to a technique that does not result in physical alteration of the fabric. This invention therefore includes an air bag cover for an air bag safety system for a vehicle comprising a fabric outer layer having a frontside and a backside and a substrate containing an opening wherein the opening has a periphery. The substrate is preferably formed by low pressure molding, wherein the fabric outer layer overlies the opening in the substrate, and wherein the fabric outer layer is weakened at a location that is adjacent or overlies the substrate opening periphery.

Nucleic acids from maize encoding proteins which suppress plant cell death

The present invention is drawn to genes from maize encoding proteins which suppress plant cell death and methods of plant transformation therewith.

Tunable Exhaust System

A tunable insert assembly for a tunable exhaust system is disclosed for use with an air intake engine of a vehicle. The tunable exhaust system may include an intake tube having first and second ends with a first flange, an exhaust tube having third and fourth ends with a second flange, and a clamp to securely affix the first flange of intake tube to the second flange of exhaust tube. The tunable insert assembly may comprise a register ring, insert, and orifice plate with an opening. The insert may be perpendicularly disposed through the opening of orifice plate, while the register ring may be disposed over and circumferentially surrounds an outermost surface of orifice plate. Lastly, the exhaust system may be configured to produce a desired range of tunable sound pressure levels and a desired tunable sound frequency range based on various predetermined diameters and lengths related to the insert(s). 1. A tunable exhaust system for an internal combustion engine of a vehicle , comprising:a first tube having a first end and a second end;a second tube having a third end and a fourth end;a securing element configured to securely affix the second end of the first tube to the third end of the second tube; and the tunable insert has a first open end and a second open end;', 'the orifice plate has a first end, a second end, and an opening; and', 'wherein the tunable insert assembly is configured to:, 'a tunable insert assembly having an insert, an orifice plate, and a register ring, whereindirect air from the first tube to the second tube, and produce a range of tunable sound pressure levels based on one or more predetermined diameters and lengths.2. The tunable exhaust system of claim 1 , wherein the insert is perpendicularly disposed through the opening claim 1 , wherein the register ring is disposed over an outer peripheral surface of the orifice plate claim 1 , wherein the register ring and orifice plate are affixed between the second and third ends of the first and ...

Rotating wedge leveler

An apparatus and method for mounting underwater turbines that includes a mechanism for correcting tilt error, including both the amount and direction of error, associated with the installation of underwater turbines onto anchoring or mounting structures so that the yaw axis of the mounted turbines will be as close as possible to a desired angle, preferably vertical.

Infusion device and driving mechanism and process for same with actuator for multiple infusion uses

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. The armature may be configured with a reduced diameter by including a coil cup for supporting the coil including a shelf portion defining at least a portion of a pole surface of the coil cup.

Optimised coding sequence and promoter

An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium to an outlet chamber located at one end of the piston channel. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position ...

INFUSION DEVICE WITH A GROOVED PISTON CHANNEL WALL

An apparatus for delivering a fluid includes a housing, an inlet in the housing for receiving the fluid, and an outlet in the housing for discharging the fluid. A piston channel is provided within the housing through which the fluid flows from the inlet to the outlet. An actuator is positioned within the housing and is moveable between a retracted position and a forward position, the actuator defining a piston chamber for storing fluid received through the inlet when the actuator is in the retracted position and for driving the fluid stored in the piston chamber toward the outlet when the actuator transitions from the retracted position to the forward position. The actuator includes an armature and a piston coupled to the armature and moveable within the piston channel. The piston channel wall is provided with a groove for conducting fluid from the inlet to the outlet. 1. An apparatus for delivering a fluid , the apparatus comprising:a housing;an inlet in the housing for receiving the fluid;an outlet in the housing for discharging the fluid;a piston channel within the housing through which the fluid flows from the inlet to the outlet, the piston channel having a piston channel wall with at least one groove provided therein; and an armature; and', 'a piston coupled to the armature and moveable within the piston channel, the piston having an outer surface, wherein the at least one groove of the piston channel wall facilitates fluid flow from the inlet to the outlet., 'an actuator positioned within the housing and moveable between a retracted position and a forward position, the actuator defining a piston chamber for storing fluid received through the inlet when the actuator is in the retracted position, the actuator driving the fluid stored in the piston chamber toward the outlet when the actuator transitions from the retracted position to the forward position, the actuator comprising2. The apparatus of claim 1 , wherein the at least one groove comprises a helical ...

Roof access device for a vehicle

An apparatus for enabling a user to access a roof of the vehicle. The apparatus may be positioned within a cavity that is located on a front surface of a B-pillar or a C-pillar of a vehicle. The apparatus including a plate having a distal end and a proximal end, the plate movable between a stored position where the plate is positioned within the cavity and the plate is configured to be substantially flush with the front surface of the B-pillar or the C-pillar, and an extended position where a majority of the plate is positioned outside the cavity and the plate is configured to be substantially perpendicular to the front surface of the B-pillar or the C-pillar to allow the user to place his or her foot on the plate for accessing the roof of the vehicle.

Methods for making male-sterile plants

Compositions and methods for enhancing disease resistance to a pathogen in a plant are provided. Methods of the invention comprise stably transforming a plant with an antisense nucleotide sequence for a gene encoding an enzyme in the C-5 porphyrin metabolic pathway and operably linking said antisense sequence to a pathogen-inducible promoter, such that invasion of a cell by a pathogen elicits a hypersensitive-like response that results in confinement of the pathogen to cells of initial contact. Transformed plants and seeds are provided. Nucleotide sequences encoding a wild-type maize urod gene useful in the present invention and the amino acid sequence for the protein encoded thereby are provided. These compositions are also useful for regulating cell death in specifically targeted tissues. A maize lesion mimic, dominant mutant phenotype, designated Les22, and the molecular basis for its manifestation are also provided.

Polypeptide compositions for controlling cell death and disease resistance in plants

The present invention is drawn to methods and compositions for suppressing cell death in plants. Specifically, novel proteins and genes are provided for use in plant transformation. The proteins and genes are useful for activating disease resistance, enhancing plant cell transformation efficiency, engineering herbicide resistance, genetically targeting cell ablations, and other methods involving the regulation of cell death in plants.

Multicomponent fused suture loop and apparatus for making same

A fused loop of an elongated material, such as a surgical suture, and apparatus for making the loop are described. Portions of one or more segments of elongated material may be fused in an ultrasonic welding process to form a welded joint. Multiple materials each with different a different melting point may be used for one or more fibers within the elongated material. The elongated material may include a sheath, which may be used to protect a core within the elongated material. A fused region of the fused loop may be formed when a material with a lower melting temperature, compared to one or more other materials in the elongated material, is caused to melt. A related ultrasonic welding apparatus may include a temperature sensor for control of the welding process.

Method of investigating functional molecular interactions and reagents for use therein

The present invention provides a multiplexed assay for analyzing complex molecular interactions. Thus, the invention relates to a method of identifying, in a single assay, the relative binding of two or more first members of a binding pair to one or more second members of a binding pair. The invention also relates to a method of identifying, in a single assay, the relative modulation, by a modulating agent, of binding between two or more binding pairs or between two or more binding complexes. Further provided are methods of screening, in a single assay, for an agent or agents with a selected binding profile or for an agent that modulates binding between two or more first members of a binding pair and one or more second members of a binding pair or the members of two or more binding complexes. The invention also relates to a set of microspheres coupled with a set of cofactors, wherein the microspheres are labeled with a label specific for each cofactor of the set.

ROOF ACCESS DEVICE FOR A VEHICLE

An apparatus for enabling a user to access a roof of the vehicle. The apparatus may be positioned within a cavity that is located on a front surface of a B-pillar or a C-pillar of a vehicle. The apparatus including a plate having a distal end and a proximal end, the plate movable between a stored position where the plate is positioned within the cavity and the plate is configured to be substantially flush with the front surface of the B-pillar or the C-pillar, and an extended position where a majority of the plate is positioned outside the cavity and the plate is configured to be substantially perpendicular to the front surface of the B-pillar or the C-pillar to allow the user to place his or her foot on the plate for accessing the roof of the vehicle. 1. An apparatus for enabling a user to access a roof of the vehicle , the apparatus is positioned within a cavity that is located on a front surface of a B-pillar or a C-pillar of a vehicle , the apparatus comprising:a housing having a rear portion and defining a cavity, the rear portion having a front surface and a rear surface, the front surface being located within the cavity;a rod positioned within the cavity and extending along a width of the cavity; and a stored position where the plate is positioned within the cavity and the plate is configured to be substantially flush with the front surface of the B-pillar or the C-pillar, the stepping surface of the plate contacting the front surface of the rear portion of the housing, and', 'an extended position where a majority of the plate is positioned outside the cavity and the plate is configured to be substantially perpendicular to the front surface of the B-pillar or the C-pillar to allow the user to place his or her foot on the stepping surface of the plate for accessing the roof of the vehicle., 'a plate having a distal end, a proximal end attached to the rod, and a stepping surface, the plate movable between'}2. The apparatus of further comprising a spring coupled ...

Infusion device having piston operated driving mechanism and positive pressure reservoir

A piston-type drive mechanism in combination with a positive pressure reservoir for delivery of infusion medium. A coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium from the positive pressure reservoir to an outlet chamber. A piston is located within the piston channel and is moveable axially within the channel to a forward position. The piston is moved toward a retracted position, when the coil is not energized. As the piston is moved to its forward position, pressure moves a valve member into an open position. When the valve member is in the open position, medium from the piston chamber is discharged into the outlet chamber. An outlet is provided in flow communication with the outlet chamber, for discharging infusion medium from the outlet chamber.

Athletic apparel with applied indicia

Apparel are disclosed that include resilient indicia, applied thereto using a resilient adhesive film, to produce lightweight, comfortable, aesthetically appealing garments and uniforms for athletes and other uniformed individuals. A method of manufacturing apparel with indicia is described and includes creating a digital image of desired indicia and transferring the digital image onto a textile substrate. The textile substrate is processed and laminated to the apparel in a predetermined position and orientation using an activatable film.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium has a coil and an armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is moveable axially within a piston channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position, the piston chamber volume is reduced and pressure within the piston chamber increases to a point where the pressure moves the valve member into an open position through an outlet.

WAKEWORD DETECTION

Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. If the DSP’s wakeword detection component detects a wakeword in speech, the companion application’s wakeword detection component may be used to determine whether the wakeword was spoken by the user of the device. If the companion application’s wakeword detection component determines the user spoke the wakeword, audio data representing the speech may be sent to at least one server(s) for processing.

Controlled tether arrangement for an airbag

An airbag door construction for airbag deployment comprising a hard instrument panel having a weakened area outlining at least a portion of an integrally molded airbag door. A reaction plate is attached to the underside of the panel at the airbag door location. A deployment chute is molded with the reaction plate and attached to the hard instrument panel just outboard of the outline of the airbag door. A tether is included that engages with the reaction plate whereupon airbag deployment the tether allows the airbag door/reaction plate welded combination to break loose from the hard instrument panel in a controlled manner.

Airbag door and method for making same

An airbag door system is provided comprising a substrate, an outer shell and a foam where all three layers possess a line of mechanical weakness with each line of mechanical weakness at least partially separating each layer into an airbag door portion and a trim member portion. The substrate line of mechanical weakness comprises at least one substrate aperture. The outer shell line of mechanical weakness comprises an outer shell reduced thickness portion defined by an outer shell sever extending partially through an outer shell thickness from an outer shell lower surface towards an outer shell upper surface. The foam line of mechanical weakness comprises a foam reduced thickness portion defined by a foam sever extending partially through a foam thickness from a foam lower surface towards a foam upper surface. The outer shell line of mechanical weakness is displaced relative to a foam line of mechanical weakness.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium to an outlet chamber located at one end of the piston channel. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position ...

Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins

Novel packaging cell lines useful for generating viral accessory protein independent HIV-derived retroviral vector particles, methods of constructing such packaging cell lines and methods of using the viral accessory protein independent HIV-derived retroviral vector particles are disclosed.

SYSTEMS AND METHODS FOR PROVIDING AIRFLOW IN AN AEROSPACE VEHICLE

Systems and methods for providing airflow in an aerospace vehicle are disclosed. A system in accordance with one embodiment includes an aerospace vehicle having an interior volume with a first portion and a second portion. The system can further include an external air supply device positioned to provide supply air to the interior volume at a variable supply flow rate and a recirculation fan configured to move air positioned within the interior volume between the first portion of the interior volume and the second portion of the interior volume. The system can still further include a controller operably coupled to the recirculation fan and configured to vary a rotation speed of the recirculation fan. Variations in the rotation speed of the recirculation fan can be associated with variations in a recirculation flow rate. In selected embodiments, the system can include sensors and/or data link devices operably coupled to the controller.

Single sided power generator support frame

We describe a cantilevered power generation system and the support therefor which permits the system to be easily mounted to a fixed shore line or water way so that a vertically oriented rotor can be positioned in the moving flow and be rotted to generate power. The support structure allows the power generation system to be easily removed, moved and also allow the structure to be raised thus permitting the repair and/or replacement of the rotor assembly.

WAKEWORD DETECTION

Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. If the DSP's wakeword detection component detects a wakeword in speech, the companion application's wakeword detection component may be used to determine whether the wakeword was spoken by the user of the device. If the companion application's wakeword detection component determines the user spoke the wakeword, audio data representing the speech may be sent to at least one server(s) for processing.

Actuator with grooved piston for a fluid infusion device

An apparatus for delivering a fluid includes a housing, an inlet in the housing for receiving the fluid, and an outlet in the housing for discharging the fluid. A piston channel is provided within the housing through which the fluid flows from the inlet to the outlet. An actuator is positioned within the housing and is moveable between a retracted position and a forward position, the actuator defining a piston chamber for storing fluid received through the inlet when the actuator is in the retracted position and for driving the fluid stored in the piston chamber toward the outlet when the actuator transitions from the retracted position to the forward position. The actuator includes an armature and a piston coupled to the armature and moveable within the piston channel. The piston is provided with a groove in an outer surface for conducting fluid from the inlet to the outlet.

Rotating wedge leveler

An apparatus and method for mounting underwater turbines that includes a mechanism for correcting tilt error, including both the amount and direction of error, associated with the installation of underwater turbines onto anchoring or mounting structures so that the yaw axis of the mounted turbines will be as close as possible to a desired angle, preferably vertical.

Stiffening frame for an integral tether and tearstop in an air bag door

An air bag door construction for air bag deployment comprises a trim panel and air bag door of unitary construction, at least a portion of the door defined by an area of reduced cross-section outlining at least a portion of the periphery thereof. One or more tethers are formed in the panel, outlined by an area of reduced cross-section, preferably in a dovetail shape which does not direct the propagation of tearing into the tether. A tear stop may be formed at the ends of the tether. The improvement comprises a stiffening frame that is attached to the backside and/or the topside of the panel just outboard of the air bag door periphery but not located across the tethers to improve deployment performance.

Restorative cleaning Process

The present invention is a deep cleaning process for carpets through its unique restorative cleaning process. The present comprises a use of restorative cleaning agent and cleansers according to the pH level of the stain, and a method either of agitating with hand-held polyester carpet brush or of rotary power scrubbing with polyester brush. Through its unique deep cleaning process including anti-ghost stain treatment to prevent the stain from re-appearing, the present invention will yield cleaner cleaning process than the industry standard cleaning method. In an alternative embodiment of the Restorative Cleaning Process of the present invention, man-made carpet fibers are cleaned using a series of cleaning steps designed to extract soil particulates from the fibers of the carpet and decrease the time it takes for the carpet to dry. In addition, an anti-reappearing ghost spot device utilizing the anti-reappearing ghost spot post-treatment is used to prevent spots from re-appearing. 1. A restorative cleaning process , comprising the steps of:selecting a carpet area to be cleaned; applying a pre-conditioner having a pH of 7-10 to the carpet area,', 'agitating the pre-conditioner, and', 'extracting the pre-conditioner from the carpet area;, 'performing a second cycle comprising applying a rinse having a pH of 3-6 to the carpet area, and', 'extracting the rinse; and, 'performing a third cycle comprisingperforming a fourth cycle comprising applying an anti-reappearing ghost spot treatment having a pH of 3-6 to the carpet area.2. The restorative cleaning process as recited in claim 1 , wherein the pre-conditioner is applied at low pressure claim 1 , the rinse is applied at high pressure and high heat claim 1 , and the anti-reappearing ghost spot treatment is applied at low pressure and high heat.3. The restorative cleaning process as recited in claim 2 , wherein the rinse is applied at 350-400 PSI and 220-240 degrees Fahrenheit.4. The restorative cleaning process as ...

Wakeword detection

Techniques for processing incoming audio using multiple wakeword detectors are described. Audio data representing an utterance may be processed by different wakeword detectors that can detect different wakewords and are associated with different speech processing components. When a wakeword is detected by one of the wakeword detectors, it may be processed by the corresponding speech processing component.

ROSE PLANT NAMED 'GRASUPER'

A new and distinct floribunda type Rosa hybrid named ‘GRAsuper’ is disclosed, characterized by complete resistance to Diplocarpon rosae and continuous flowering. Plants produce pink flowers with a strong fragrance and typically reach a height of between 1 to 1.2 meters. The new cultivar is a Rosa typically suited for ornamental container and landscape use.

Airbag door and method for making same

An airbag door system is provided comprising a substrate, an outer shell and a foam where all three layers possess a line of mechanical weakness with each line of mechanical weakness at least partially separating each layer into an airbag door portion and a trim member portion. The substrate line of mechanical weakness comprises at least one substrate aperture. The outer shell line of mechanical weakness comprises an outer shell reduced thickness portion defined by an outer shell sever extending partially through an outer shell thickness from an outer shell lower surface towards an outer shell upper surface. The foam line of mechanical weakness comprises a foam reduced thickness portion defined by a foam sever extending partially through a foam thickness from a foam lower surface towards a foam upper surface. The outer shell line of mechanical weakness is displaced relative to a foam line of mechanical weakness.

Maize lls1 promoter

The present invention is drawn to a maize lls1 promoter that can be used in DNA constructs to express polynucleotides in plants, plant cells, tissues and seeds.

Kinetic hydro power triangular blade hub

A rotor hub mounting arrangement for removably mounting a plurality of turbine rotor blades to the rotor hub in a compact and secure manner. The rotor hub includes an internal mounting assembly, preferably comprised of a series of interconnected mounting plates, positioned adjacent a series of foil shaped openings in the rotor hub into which the root end of turbine blades can be inserted and removably mounted to the internal mounting assembly.

Rose plant named ‘GRAsuper’

A new and distinct floribunda type Rosa hybrid named ‘GRAsuper’ is disclosed, characterized by complete resistance to Diplocarpon rosae and continuous flowering. Plants produce pink flowers with a strong fragrance and typically reach a height of between 1 to 1.2 meters. The new cultivar is a Rosa typically suited for ornamental container and landscape use.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium has a coil and an armature moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is moveable axially within a piston channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position, the piston chamber volume is reduced and pressure within the piston chamber increases to a point where the pressure moves the valve member into an open position through an outlet.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium. A coil surrounds a piston channel. An armature is located adjacent the coil. The armature is moveable toward a forward position in response to the electromagnetic field produced by activation of the coil. A piston located within the piston channel is moveable within the channel to a forward position in response to movement of the armature. The armature and piston are moved toward a retracted position when the coil is not energized. In the retracted position, a piston chamber formed between the piston and a valve member filled with infusion medium. As the piston is moved to its forward position, piston chamber volume is reduced and pressure within the piston chamber increases and moves the valve member into an open position. Medium from the piston chamber is then discharged into an outlet chamber.

Method for embedding a distinguishing aesthetic and/or functional surface feature into a panel surface

A method for embedding a distinguishing aesthetic and/or functional surface feature into a panel surface is described. An open mesh sheet of material is applied to a mold surface and plastic applied to the mold surface and to the back side of the open mesh material. The plastic forms a shell that is then removed from the mold with the open mesh material at least partially embedded in the surface of the shell. The shell then may be used as a trim panel that includes the aesthetic and functional features of the open mesh material.

Towed vehicle brake controls

A towed vehicle braking system and method for applying brakes to a towed vehicle. The towed vehicle braking system may include a master controller, a brake pedal activation device, and a breakaway cable. The master controller may be mountable in a towing vehicle and may be selectively placed in a trailer mode or a powered vehicle mode. A brake signal wire used to apply braking power to trailer brakes may be used for communication between the master controller and the brake pedal activation device. The brake pedal activation device may use a force sensor to determine that a force applied to a brake pedal of the towed vehicle corresponds to a desired amount of braking force as indicated by the master controller. The breakaway cable may be a combination of a traditional breakaway switch and an electrical cord between the towed and towing vehicles.

Method of marking a skin for a vehicle interior panel

A method of marking a skin for a vehicle interior trim panel comprising providing a skin with a color and an outer surface. A laser is applied to the outer surface such that a portion of the skin surface contacted by the laser changes color relative to a portion of the outer skin not contacted by the laser to create a marking in the outer skin surface indicating the presence of a vehicle component or function. In particular, an image, pattern, or color contrast may be created on the skin. A unique hole pattern and size distribution caused by the laser may provide a skin with a woven fabric texture. In addition, stitches formed on a skin surface may be colored differently from the surrounding skin surface to distinguish their appearance.

Optimised coding sequence and promoter

An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes arc alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment.

OPTIMISED CODING SEQUENCE AND PROMOTER

An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocyte biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment. 122-. (canceled)23. A promoter comprising a nucleotide sequence having at least 90% identity to the nucleotide sequence of SEQ ID NO:3.24. The promoter of comprising a nucleotide sequence having at least 95% identity to the nucleotide sequence of SEQ ID NO:3.25. The promoter of comprising the nucleotide sequence of SEQ ID NO:3.26. The promoter of consisting essentially of the nucleotide sequence of SEQ ID NO:3.27. The promoter of consisting of the nucleotide sequence of SEQ ID NO:3.28. The promoter of that is liver-specific.29. A vector comprising the promoter of .30. The vector of claim 29 , wherein the promoter is operably linked to a nucleotide sequence which encodes a functional factor VIII protein.31. The vector of claim 30 , wherein the functional factor VIII protein is encoding by the nucleotide sequence of SEQ ID NO:1 claim 30 , 4 claim 30 , 5 claim 30 , 6 or 7.32. The vector of which is a recombinant adeno-associated virus (rAAV) vector.33. A host cell comprising the vector of .34. A method of treating hemophilia A in a mammal comprising administering to said mammal the vector of . The invention relates to an optimised coding sequence of human blood clotting factor eight (VIII) and a new promoter, which may be used in such vectors as rAAV for introduction of factor VIII, other blood clotting factors and transgenes including those involved in the coagulation cascade, hepatocytes biology, lysosomal storage, and urea ...

Infusion device having piston operated driving mechanism and positive pressure reservoir

A piston-type drive mechanism in combination with a positive pressure reservoir for delivery of infusion medium. A coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium from the positive pressure reservoir to an outlet chamber. A piston is located within the piston channel and is moveable axially within the channel to a forward position. The piston is moved toward a retracted position, when the coil is not energized. As the piston is moved to its forward position, pressure moves a valve member into an open position. When the valve member is in the open position, medium from the piston chamber is discharged into the outlet chamber. An outlet is provided in flow communication with the outlet chamber, for discharging infusion medium from the outlet chamber.

Apparatus and method for upgrading a hospital room

A mobile care cart adapted to carry a battery and a fluid supply has a first display to provide battery-related information and a second display to provide fluid supply-related information. The battery may be coupled to patient care equipment located on the cart. The first display may indicate the status of the battery charge level. The cart may include a fluid port located on the cart and coupled to a fluid supply. The second display may indicate if the fluid supply is below a predetermined level. The first and second displays may be located on an upwardly-facing top wall of the cart.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium to an outlet chamber located at one end of the piston channel. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position ...

Infusion device and driving mechanism and process for same with actuator for multiple infusion uses

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. The armature may be configured with a reduced diameter by including a coil cup for supporting the coil including a shelf portion defining at least a portion of a pole surface of the coil cup.

Infusion device and actuator for same

An apparatus for delivering a fluid includes a housing, an inlet in the housing for receiving the fluid, and an outlet in the housing for discharging the fluid. A piston channel is provided within the housing through which the fluid flows from the inlet to the outlet. An actuator is positioned within the housing and is moveable between a retracted position and a forward position, the actuator defining a piston chamber for storing fluid received through the inlet when the actuator is in the retracted position and for driving the fluid stored in the piston chamber toward the outlet when the actuator transitions from the retracted position to the forward position. The actuator includes an armature and a piston coupled to the armature and moveable within the piston channel. The piston is provided with a groove in an outer surface for conducting fluid from the inlet to the outlet.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium has a coil and an armature movable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is movable axially within a piston channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position, the piston chamber volume is reduced and pressure within the piston chamber increases to a point where the pressure moves the valve member into an open position through an outlet.

Cable jacket sealing, pressurization, and monitoring

An underwater power generating system includes an underwater power generating device, a closed nacelle and a connecting cable system that is provided with an open passage way extending there along that is sealed at one end to the interior of the closed nacelle. The cable system can be used in a number of ways, such as by having the second end being sealed, to prevent air from escaping the closed nacelle, or by having the second end connected to a source of positive pressure thereby permitting the cable to be sufficiently pressurized to provide a positive pressure internally within the closed nacelle that is at least slightly greater than the nacelle at depth pressure, and thus greater than water pressure acting on the exterior of the closed nacelle, to prevent water ingress within the nacelle, as well as to transmit power and/or other data between the nacelle and shore monitoring and control facilities.

Acylalkylisethionate esters and applications in consumer products

Acylalkylisethionate esters are produced by reacting one or more carboxylic acids with one or more alkyl-substituted hydroxyalkyl sulfonates under esterification reaction conditions. The alkyl-substituted hydroxyalkyl sulfonates used as a raw material in producing the esters are prepared by reacting bisulfate with one or more alkylene oxides. The acylalkylisethionate esters may be used in consumer products.

Infusion device and driving mechanism and process for same with actuator for multiple infusion uses

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. The armature may be configured with a reduced diameter by including a coil cup for supporting the coil including a shelf portion defining at least a portion of a pole surface of the coil cup.

ACTUATOR WITH GROOVED PISTON FOR A FLUID INFUSION DEVICE

An apparatus for delivering a fluid includes a housing, an inlet in the housing for receiving the fluid, and an outlet in the housing for discharging the fluid. A piston channel is provided within the housing through which the fluid flows from the inlet to the outlet. An actuator is positioned within the housing and is moveable between a retracted position and a forward position, the actuator defining a piston chamber for storing fluid received through the inlet when the actuator is in the retracted position and for driving the fluid stored in the piston chamber toward the outlet when the actuator transitions from the retracted position to the forward position. The actuator includes an armature and a piston coupled to the armature and moveable within the piston channel. The piston is provided with a groove in an outer surface for conducting fluid from the inlet to the outlet.

System for providing ride matching services using e-mail and the internet

An on-line ride sharing system employs a dynamic database of geographical information in map form together with information that is input into the system by individual users and potential users of the system. An analysis program is integrated with the database to evaluate applications filed by users, and to present a user with a map display of origin and destination locations of potential ride sharing partners. A communication route is provided by the system between the user and potential partners to allow the parties to maintain anonymity and privacy so long as is desired.

Turbine yaw control

A KHP system turbine for the production of energy in an underwater environment including a yaw stop arrangement for use in flowing steams where the flow direction of water therein is changeable, including bi-directional and multi-directional current flows, so that a rotatably mounted turbine remains in an optimal position within such changing flow conditions. The KHP turbine includes a rotational portion and one or two passive yaw stop assemblies that will control turbine yaw and keep the turbine oriented to capture energy from changeable underwater current flows.

WAKEWORD DETECTION

Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. If the DSP's wakeword detection component detects a wakeword in speech, the companion application's wakeword detection component may be used to determine whether the wakeword was spoken by the user of the device. If the companion application's wakeword detection component determines the user spoke the wakeword, audio data representing the speech may be sent to at least one server(s) for processing. 120.-. (canceled)21. A computer-implemented method , comprising:receiving first audio data corresponding to an utterance; a first wakeword detection component configured to detect a representation of at least a first wakeword, the first wakeword detection component being associated with a first speech processing component, and', 'a second wakeword detection component configured to detect a representation of at least a second wakeword different from the first wakeword, the second wakeword detection component being associated with a second speech processing component;, 'processing the first audio data usingdetermining the utterance includes the first wakeword; andcausing the first speech processing component to process further audio data.22. The computer-implemented method of claim 21 , wherein:the first speech processing component is associated with a first speech processing system;the second speech processing component is associated with a second speech processing system different from the first speech processing system; andthe method further comprises sending the further audio data to the first speech processing component associated with the first speech processing system.23. The computer-implemented ...

Wakeword detection

Techniques for implementing multiple wakeword detectors on a single device are described. A digital signal processor (DSP) of the device may implement a wakeword detection component to detect when captured speech includes a wakeword. A companion application installed on the device may implement a wakeword detection component trained using speech of a user of the device. In response to determining that the user spoke the wakeword, the companion application may send audio data representing the speech and data corresponding to the user to at least one server(s) for processing. Further, the device may receive captured speech and captured image data corresponding to the captured speech and determine a representation of a user in the captured image data. If the device determines the user is represented in the image data, audio data representing the speech may be sent to at least one server(s) for processing.

Kinetic hydro power triangular blade hub

A rotor hub mounting arrangement for removably mounting a plurality of turbine rotor blades to the rotor hub in a compact and secure manner. The rotor hub includes an internal mounting assembly, preferably comprised of a series of interconnected mounting plates, positioned adjacent a series of foil shaped openings in the rotor hub into which the root end of turbine blades can be inserted and removably mounted to the internal mounting assembly.

Actuator with grooved piston for a fluid infusion device

An apparatus for delivering a fluid includes a housing, an inlet in the housing for receiving the fluid, and an outlet in the housing for discharging the fluid. A piston channel is provided within the housing through which the fluid flows from the inlet to the outlet. An actuator is positioned within the housing and is moveable between a retracted position and a forward position, the actuator defining a piston chamber for storing fluid received through the inlet when the actuator is in the retracted position and for driving the fluid stored in the piston chamber toward the outlet when the actuator transitions from the retracted position to the forward position. The actuator includes an armature and a piston coupled to the armature and moveable within the piston channel. The piston is provided with a groove in an outer surface for conducting fluid from the inlet to the outlet.

Alkanolamide surfactant emulsions and process therefor

Phase stable, pumpable, liquid, high solids, aqueous monoalkanolamide surfactant emulsions are disclosed for use as cold mixable monoalkanolamide delivery systems for separately prepared aqueous formulations containing at least one principal surfactant. The monoalkanolamide surfactant emulsions comprise at least one monoalkanolamide characterized in its unemulsified form by having an amide content of at least about 85% and by being substantially solid and water insoluble at a temperature below about 30° C., and at least one monoalkanolamide emulsifying surfactant and, surprisingly, remain homogeneous, pourable, and pumpable at a total solids content of at least 20 weight percent at a temperature in the range of about zero ° C. to about 30° C.

Pressure actuated valve

A pressure actuated valve is provided including a valve body having a fluid inlet chamber, an actuation chamber, and an outlet. The chambers and the outlet are configured for selective fluid communication with one another. A plunger is disposed within at least a portion of the actuation chamber for selective movement between open and closed positions. A sealing surface is situated adjacent to the actuation chamber and is correspondingly configured to effectively seal with the plunger in its closed position to block fluid communication from the fluid inlet chamber to the outlet. A biasing member is associated with the plunger and is configured to normally bias the plunger toward the open position. The plunger is configured to move into the closed position when pressure in the actuation chamber reaches a predetermined pressure setpoint. A condenser system for a fuel storage tank system having a pressure actuated valve is also provided.

Cloth covered instrument panel

An instrument panel for a vehicle comprising a first coverstock segment having an outer surface and an inner surface and a mating edge disposed along a portion of a common perimeter of the outer surface and inner surface. A second coverstock segment is supplied having an outer surface and inner surface and a mating edge disposed along a portion of a common perimeter bounding the outer surface and the inner surface, the second coverstock segment bonded to the first coverstock segment along the respective mating edges forming a joint line. At least one of the first coverstock segment and the second coverstock segment is a cloth or fabric.

Polypeptide compositions for controlling cell death and disease resistance in plants

The present invention is drawn to methods and compositions for suppressing cell death in plants. Specifically, novel proteins and genes are provided for use in plant transformation. The proteins and genes are useful for activating disease resistance, enhancing plant cell transformation efficiency, engineering herbicide resistance, genetically targeting cell ablations, and other methods involving the regulation of cell death in plants.

Manifold and regulator apparatus

A manifold assembly is provided which includes a manifold block having a gas inlet and a gas outlet. The block also includes a regulator inlet in a planar surface of the manifold block which is connected to the gas inlet. The regulator outlet is also provided in the planar surface spaced from the regulator inlet and connected to the gas outlet. A regulator is mounted to the manifold block at the planar surface and includes an inlet and outlet on a common wall of the regulator. The inlet and outlet of the regulator have the same spacing as and communicates with the regulator inlet and outlet of the manifold block. In the preferred embodiment, one of the inlet and outlet of the regulator is annular and encompasses the other.

Methods and compositions for regulating cell death and enhancing disease resistance to plant pathogens

Compositions and methods for enhancing disease resistance to a pathogen in a plant are provided. Methods of the invention comprise stably transforming a plant with an antisense nucleotide sequence for a gene encoding an enzyme in the C-5 porphyrin metabolic pathway and operably linking the antisense sequence to a pathogen-inducible promoter, such that invasion of a cell by a pathogen elicits a hypersensitive-like response that results in confinement of the pathogen to cells of initial contact. Transformed plants and seeds are provided. Nucleotide sequences encoding a wild-type maize urod gene useful in the present invention and the amino acid sequence for the protein encoded thereby are provided. These compositions are also useful for regulating cell death in specifically targeted tissues. A maize lesion mimic, dominant mutant phenotype, designated Les22, and the molecular basis for its manifestation are also provided.

Optimised Coding Sequence and Promoter

An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocyte biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment. 1. An isolated nucleic acid molecule comprising a nucleotide sequence having at least 75% homology to the nucleotide sequence of SEQ ID NO: 1 and which encodes functional factor FVIII.2. The nucleic acid molecule of having at least 85% homology to the nucleotide sequence of SEQ ID NO: 1.3. The nucleic acid molecule of claim 1 , which encodes for a protein comprising the sequence of SEQ ID NO: 2 or SEQ ID NO: 21 having between 0 and 10 amino acid changes thereto.4. The nucleic acid molecule of claim 3 , which encodes for a protein comprising the sequence of SEQ ID NO: 2 or SEQ ID NO: 21.5. The nucleic acid molecule of comprising a nucleotide sequence selected from the sequence of SEQ ID NO: 1 claim 1 , SEQ ID NO: 4 claim 1 , SEQ ID NO: 5 claim 1 , SEQ ID NO: 6 and SEQ ID NO: 7.6. The nucleic acid molecule of further comprising a nucleotide sequence having at least 85% homology to the nucleotide sequence of SEQ ID NO: 3.7. A vector comprising a nucleic acid molecule of .8. A host cell comprising the nucleic acid molecule of or the vector of .9. A protein or glycoprotein expressed by the host cell of .10. (canceled)11. A method of treating haemophilia comprising administering a vector according to to a patient suffering from haemophilia.12. (canceled)13. (canceled)14. A method for delivery of a nucleotide sequence encoding a functional factor VIII to a subject claim 1 , which method comprises administering to the said subject a ...

ACTUATOR WITH GROOVED PISTON FOR A FLUID INFUSION DEVICE

An apparatus for delivering a fluid includes a housing, an inlet in the housing for receiving the fluid, and an outlet in the housing for discharging the fluid. A piston channel is provided within the housing through which the fluid flows from the inlet to the outlet. An actuator is positioned within the housing and is moveable between a retracted position and a forward position, the actuator defining a piston chamber for storing fluid received through the inlet when the actuator is in the retracted position and for driving the fluid stored in the piston chamber toward the outlet when the actuator transitions from the retracted position to the forward position. The actuator includes an armature and a piston coupled to the armature and moveable within the piston channel. The piston is provided with a groove in an outer surface for conducting fluid from the inlet to the outlet. 1. An actuator for delivering fluid through a piston channel , from a first fluid chamber above the piston channel to a second fluid chamber below the piston channel , the actuator comprising:an armature that moves between a forward position and a retracted position; anda piston coupled to the armature and moveable within the piston channel, the piston having an inlet end and an outlet end, the inlet end located in the first fluid chamber and the outlet end in fluid communication with the second fluid chamber, and the piston comprising an outer surface and at least one helical groove in the outer surface from the inlet end to the outlet end, the at least one helical groove forming a flow path between the first fluid chamber and the second fluid chamber for conducting fluid;wherein the helical groove has a number of turns, a depth, a width, and a pitch that inhibits back leakage of fluid from the second fluid chamber to the first fluid chamber during movement of the armature from the retracted position to the forward position.2. The actuator of claim 1 , wherein the at least one helical groove ...

Mandevilla plant named ‘Scarlet Velvet’

A new and distinct Mandevilla cultivar named ‘Scarlet Velvet’ is disclosed, characterized by having distinctive flower coloration, opening pink and turning red, early blooming habit and moderate growth and branching characteristics. The new variety is a Mandevilla, normally produced as an outdoor garden or container plant.

Methods for making and using regulatory T cells

The invention is generally related to methods of making regulatory T cells and treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium to an outlet chamber located at one end of the piston channel. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position ...

Cancer treatment method

The invention relates to a method for treating cancer including administering to a mammal therapeutically effective amounts of an anti-neoplastic agent and a PDE4 inhibitor, treatment combinations containing the same as well as a method for attenuating unwanted cancer treatment side effects including myelosuppression and mucositis.

Turbine yaw control

A KHP system turbine for the production of energy in an underwater environment including a yaw stop arrangement for use in flowing steams where the flow direction of water therein is changeable, including bi-directional and multi-directional current flows, so that a rotatably mounted turbine remains in an optimal position within such changing flow conditions. The KHP turbine includes a rotational portion and one or two passive yaw stop assemblies that will control turbine yaw and keep the turbine oriented to capture energy from changeable underwater current flows.

Alkanolamide surfactant emulsions and process therefor

Phase stables, pumpable, liquid, high solids, aqueous monoalkanolamide surfactant emulsions are disclosed for use as cold mixable monoalkanolamide delivery systems for separately prepared aqueous formulations containing at least one principal surfactant. The monoalkanolamide surfactant emulsions comprise at least one monoalkanolamide characterized in its unemulsified form by having an amide content of at least about 85% and by being substantially solid and water insoluble at a temperature below about 30° C., and at least one monoalkanolamide emulsifying surfactant and, surprisingly, remain homogeneous, pourable, and pumpable at a total solids content of at least 20 weight percent at a temperature in the range of about zero° C. to about 30° C.

NOVEL ACYLALKYLISETHIONATE ESTERS AND APPLICATIONS IN CONSUMER PRODUCTS

Acylalkylisethionate esters are produced by reacting one or more carboxylic acids with one or more alkyl-substituted hydroxyalkyl sulfonates under esterification reaction conditions. The alkyl-substituted hydroxyalkyl sulfonates used as a raw material in producing the esters are prepared by reacting bisulfate with one or more alkylene oxides. The acylalkylisethionate esters may be used in consumer products.

Tank pressure management system

A tank pressure management system includes a vapor condensing system in fluid communication with a storage tank and an accumulator vessel in fluid communication with the vapor condensing system and a storage tank. The accumulator vessel includes an air/vapor conduit and a liquid conduit connected to a storage tank. A method of managing air/vapor pressure of a storage tank includes the steps of monitoring the pressure in a storage tank, removing air/vapor from a storage tank, separating liquid from the air/vapor, returning all remaining air/vapor to a storage tank and returning the liquid to a storage tank.

Alkanolamide surfactant emulsions and process therefor

Phase stable, pumpable, liquid, high solids, aqueous monoalkanolamide surfactant emulsions are disclosed for use as cold mixable monoalkanolamide delivery systems for separately prepared aqueous formulations containing at least one principal surfactant. The monoalkanolamide surfactant emulsions comprise at least one monoalkanolamide characterized in its unemulsified form by having an amide content of at least about 85% and by being substantially solid and water insoluble at a temperature below about 30° C., and at least one monoalkanolamide emulsifying surfactant and, surprisingly, remain homogeneous, pourable, and pumpable at a total solids content of at least 20 weight percent at a temperature in the range of about zero ° C. to about 30° C.

Methods for controlling cell death in plants

The present invention is drawn to methods and compositions for suppressing cell death in plants. Specifically, novel proteins and genes are provided for use in plant transformation. The proteins and genes are useful for activating disease resistance, enhancing plant cell transformation efficiency, engineering herbicide resistance, genetically targeting cell ablations, and other methods involving the regulation of cell death in plants.

Infusion device and driving mechanism and process for same with actuator for multiple infusion uses

A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. The armature may be configured with a reduced diameter by including a coil cup for supporting the coil including a shelf portion defining at least a portion of a pole surface of the coil cup.

Controlled tether arrangement for an airbag

An airbag door construction for airbag deployment comprising a hard instrument panel having a weakened area outlining at least a portion of an integrally molded airbag door. A reaction plate is attached to the underside of the panel at the airbag door location. A deployment chute is molded with the reaction plate and attached to the hard instrument panel just outboard of the outline of the airbag door. A tether is included that engages with the reaction plate whereupon airbag deployment the tether allows the airbag door/reaction plate welded combination to break loose from the hard instrument panel in a controlled manner.

Rosa plant named ‘GRAppl’

A new and distinct floribunda type Rosa hybrid named ‘GRAppl’ is disclosed, characterized by complete resistance to Diplocarpon rosae and strong tolerance for powdery mildew. Plants produce dark red-purple flowers with a strong fragrance and are typically dense and twiggy, reaching a height of between 1 to 1.2 meters. The new cultivar is a Rosa typically suited for ornamental container and landscape use.

Method for casting multicolored parts for automotive interior applications

The present invention relates to an apparatus/method for making a joint line in a plastic article comprising the steps of providing a mold having a mold surface, providing a gasket in the mold wherein the gasket defines first and second mold spaces, and molding a layer of a plastic material within one of the mold first and second mold spaces. In addition, during molding, the gasket is laterally moved relative to the mold surface in a direction towards that mold space containing the plastic material to therein form a distinct joint line. In alternative embodiment, a method is disclosed herein for making a molded two-colored article comprising the steps of providing a mold having a mold surface, providing a gasket in the mold wherein the gasket defines first and second mold spaces, followed by the molding a layer of a first colored material within one of the mold first and second mold spaces, wherein the first colored material comprises a charge of plastic microspheres having an outside diameter ...

Optimised Coding Sequence and Promoter

An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes arc alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment. 122-. (canceled)23. A recombinant adeno-associated virus (AAV) particle comprising a heterologous nucleic acid sequence and a promoter that is operably linked to and drives expression of said heterologous nucleic acid sequence , wherein said promoter has at least 90% sequence identity to the nucleotide sequence of SEQ ID NO:3.241. The recombinant AAV particle of claim , wherein said promoter is less than 350 base pairs in length.251. The recombinant AAV particle of claim , wherein said promoter comprises the nucleotide sequence of SEQ ID NO:3.261. The recombinant AAV particle of claim , where said promoter consists essentially of the nucleotide sequence of SEQ ID NO:3.271. The recombinant AAV particle of claim , where said promoter consists of the nucleotide sequence of SEQ ID NO:3.281. The recombinant AAV particle of claim which is of AAVS serotype.291. A composition of matter comprising the recombinant AAV particle of claim and a pharmaceutically acceptable carrier. This application is a continuation of U.S. patent application Ser. No. 14/680,836, filed Apr. 7, 2015, which is a divisional of U.S. patent application Ser. No. 13/382,953, filed Apr. 18, 2012, which is a U.S. national phase filing under 35 U.S.C. §371 of International Patent Application No. PCT/US10/41378, filed Jul. 8, 2010, which claims priority to U.K. Application No. 0911870.4 filed Jul. 8, 2009, all of which are incorporated by reference herein in their ...

PIXEL CIRCUIT AND DISPLAY SYSTEM COMPRISING SAME

A display system which includes a display controller, a display unit, and a light source is disclosed. The display controller includes a processor unit, a memory device, a voltage source and, optionally, a light source control unit. The display unit includes an array of pixel cells and circuitry to receive logic and control voltages and data and operate the display, a transparent counter electrode, and a liquid crystal layer disposed between the two alignment layers. The pixel cell includes a storage element, a DC balance control switch, a pixel voltage override circuit, an inverter able to select between two voltages available to it, and a pixel electrode/mirror. In different modes of operation the pixel mirror voltage may be determined by the storage element or by the pixel voltage override circuit. The display system may display images in one period and reset to a fixed state in another period. 1. A display system comprising a display controller , a display unit comprising a plurality of pixel cells and a transparent counter electrode , and a light source;wherein said display controller comprises a processor unit, a memory device and a voltage source, and where said display controller is operative to cause a voltage source to deliver logic and control voltages and data to said display unit, including at least one voltage to a transparent counter electrode;wherein said display unit comprises a plurality of pixel cells and peripheral circuitry to receive data, and logic and drive voltages from a voltage source and operate the display according to those voltages and data, a transparent conductive counter electrode, liquid crystal alignment layers on the transparent conductive counter electrode and on the array of pixel cells, and a liquid crystal layer between the transparent counter electrode and the array of pixel cells; andwherein said pixel cell comprises a storage element, a DC balance control switch, a pixel voltage override circuit, an inverter configured to ...

OPTIMISED CODING SEQUENCE AND PROMOTER

An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment. 1. An isolated nucleic acid molecule comprising a nucleotide sequence having at least 75% homology to the nucleotide sequence of SEQ ID NO: 1 and which encodes functional factor VIII.2. The nucleic acid molecule of having at least 85% homology to the nucleotide sequence of SEQ ID NO: 1.3. The nucleic acid molecule of claim 1 , which encodes a protein comprising the sequence of SEQ ID NO: 2 or SEQ ID NO: 21 having between 0 and 10 amino acid changes thereto.4. The nucleic acid molecule of claim 3 , which encodes a protein comprising the sequence of SEQ ID NO: 2 or SEQ ID NO: 21.5. The nucleic acid molecule of comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 claim 1 , SEQ ID NO: 4 claim 1 , SEQ ID NO: 5 claim 1 , SEQ ID NO: 6 and SEQ ID NO:7.6. The nucleic acid molecule of further comprising a nucleotide sequence having at least 85% homology to the nucleotide sequence of SEQ ID NO: 3.7. A vector comprising a nucleic acid molecule according to .8. A host cell comprising the nucleic acid molecule of or the vector of .9. (canceled)10. A transgenic animal comprising cells comprising the nucleic acid molecule of .11. A method of treating haemophilia comprising administering a vector according to to a patient suffering from haemophilia.12. (canceled)13. (canceled)14. A method for delivery of a nucleotide sequence encoding a functional factor VIII to a subject claim 1 , which method comprises ...

Sterile container

A sterile container for the sterilization of surgical instruments is provided. The sterile container has a bottom wall, a side wall and a lid which, in a closed position of the sterile container, has a lid rim which engages over a free rim arranged on a side of the side wall that faces away from the bottom wall. At least one projection element is arranged between the bottom wall and the free rim. The projection element projects from the side wall in the direction of an outside of the sterile container at least as far as the lid rim and is located at a shorter distance from the bottom wall than the lid rim. The side wall, in a wall area between the at least one projection element and the free rim, does not protrude in the direction of a center of the sterile container over the side wall.

HEAD-MOUNTED POINTING DEVICE

A head-mounted pointing device is disclosed, and can be used for example for surgical training. The pointing device includes a frame or harness assembly made from a circumferential headband and a cross strap that extends over the user's (i.e. trainers) head. A laser pointer is mounted on one side of the circumferential headband, and a battery pack is provided to power the laser pointer. An user-operated pneumatically controlled switch is used to toggle the laser pointer. By moving the user's head and by activating the switch to engage the laser pointer, the trainer can point to a given target, such as material to be surgically excised from the patient during a surgical procedure. 1. A head-mounted pointing device for use by a trainer in a surgical procedure , comprising:an adjustable circumferential headband;a cross strap extending between opposite sides of the circumferential headband;a laser pointer mounted on one side of the circumferential headband wherein the laser pointer, when activated, provides a beam of light at a location dictated by the trainer;a battery pack for supplying power to the laser pointer when activated; andan user-operated pneumatically controlled switch for activating the laser pointer, wherein by moving the trainees head and engaging the switch to activate the laser pointer, the trainer can point the beam of light at a designated target during the surgical procedure.2. The pointing device of claim 1 , wherein the battery pack is mounted at the center of the cross strap.3. The pointing device of claim 1 , wherein the battery pack is mounted on the side of the circumferential headband opposite the laser pointer.4. The pointing device of claim 1 , wherein the battery pack is mounted on the side of the circumferential headband behind the laser pointer.5. The pointing device of claim 1 , wherein the laser pointer emits a red or green colored beam.6. The pointing device of claim 1 , further comprising means for controlling the circumference of ...

Secure data distribution protocol using blockchains

One or more systems and methods are presented for secure data communications utilizing blockchains. One or more systems and methods may utilize multiple blockchains to provide an immutable cryptographically linked set of blocks. Each of these blocks may contain one or more actions associated with a computer network. In one embodiment, a trusted third party may be utilized to authenticate and/or verify data prior to inputting data into one or more blockchains.

Systems and methods for air revitalization

An air revitalization system may include a humidity control device configured to remove water vapor from air within a pressurized enclosed volume. The system may further include an inlet duct configured to transport the air from the pressurized enclosed volume to the humidity control device. The system may also include an outlet duct configured to transport the air from the humidity control device to the pressurized enclosed volume. The system may include a sublimator configured to cool the air within the pressurized enclosed volume while generating additional water vapor. The system may further include a vacuum vent duct configured to transport the water vapor from the humidity control device and the additional water vapor from the sublimator to an exterior of the pressurized enclosed volume.

SYSTEMS AND METHODS FOR TEMPERATURE CONTROL

A temperature control system may include a heat exchanger configured to cool air within a pressurized enclosed crew cabin when the air is circulated across the heat exchanger and coolant is circulated through the heat exchanger. The system may further include a sublimator configured to cool the coolant. The system may also include a primary coolant line configured to transport the coolant from the sublimator through the heat exchanger. 1200. A temperature control system () comprising:{'b': 240', '242', '204', '242', '240', '252', '240, 'a heat exchanger () configured to cool air () within a pressurized enclosed crew cabin () when the air () is circulated across the heat exchanger () and coolant () is circulated through the heat exchanger ();'}{'b': 206', '252, 'a sublimator () configured to cool the coolant (); and'}{'b': 210', '252', '206', '240, 'a primary coolant line () configured to transport the coolant () from the sublimator () through the heat exchanger ().'}2. The system of claim 1 , further comprising:{'b': '280', 'at least one radiator () configured to cool the coolant, wherein the sublimator is configured to cool the coolant during a first stage of flight, and wherein the at least one radiator is configured to cool the coolant during a second stage of flight.'}3210240280. The system of claim 2 , wherein the sublimator is positioned along the coolant line () downstream from the heat exchanger () and upstream from the at least one radiator ().4232280240. The system of claim 2 , further comprising a radiator bypass valve () to alter an amount of coolant circulated through at least one radiator () and thereby control a temperature of the coolant passing through the heat exchanger ().5240106102106102270272210. The system of claim 2 , wherein the heat exchanger () is located in a service module () claim 2 , wherein the pressurized enclosed crew cabin is located in a crew module () claim 2 , wherein the service module () is separable from the crew module () ...

SYSTEMS AND METHODS FOR AIR REVITALIZATION

An air revitalization system may include a humidity control device configured to remove water vapor from air within a pressurized enclosed volume. The system may further include an inlet duct configured to transport the air from the pressurized enclosed volume to the humidity control device. The system may also include an outlet duct configured to transport the air from the humidity control device to the pressurized enclosed volume. The system may include a sublimator configured to cool the air within the pressurized enclosed volume while generating additional water vapor. The system may further include a vacuum vent duct configured to transport the water vapor from the humidity control device and the additional water vapor from the sublimator to an exterior of the pressurized enclosed volume. 1. A method for air revitalization , the method comprising:transporting air from a pressurized enclosed volume to a humidity control device;removing water vapor from the air with the humidity control device;transporting the air from the humidity control device to the pressurized enclosed volume;cooling the air within the pressurized enclosed volume while generating additional water vapor at a sublimator; andtransporting the water vapor from the humidity control device and the additional water vapor from the sublimator through a vacuum vent duct to an exterior of the pressurized enclosed volume.2. The method of claim 1 , further comprising:creating a pressure differential at an air ejector using the air, wherein the pressure differential draws additional air from the pressurized enclosed volume through an inlet vent and into a mixing section; anddiffusing a mixture of the air and the additional air into the pressurized enclosed volume.3. The method of claim 2 , further comprising:drawing the additional air across a smoke detector in proximity to the inlet vent.4. The method of claim 1 , further comprising:removing carbon dioxide from the air at a carbon dioxide control device ...

PASSENGER CABIN AIR DISTRIBUTION SYSTEM AND METHOD OF USING

A passenger cabin air distribution system includes a ventilation system and an ejector-diffuser. The ventilation system is operable to provide a conditioned air. The ejector-diffuser is positioned to receive a flow of the conditioned air from the ventilation system. The ejector-diffuser includes an induction unit and a diffuser section. The induction unit includes a secondary inlet in communication with a cabin air from a passenger cabin and is configured to mix the flow of the conditioned air with an induced flow of the cabin air into a mixed air. The diffuser section includes a discharge to eject the mixed air to the passenger cabin. The diffuser section is shaped to provide for efficient mixing with low backpressure in order to maintain the low motive pressure in the nozzle. 1. A passenger cabin air distribution system comprising:a ventilation system operable to provide a conditioned air; andan ejector-diffuser having a nozzle positioned to receive a flow of the conditioned air from the ventilation system, the ejector-diffuser including an induction unit and a diffuser section, the induction unit including a secondary inlet in communication with a cabin air from a passenger cabin and configured to mix the flow of the conditioned air with an induced flow of the cabin air into a mixed air, the diffuser section including a discharge to eject the mixed air to the passenger cabin, the flow of the conditioned air within the nozzle having a low motive pressure.2. The passenger cabin air distribution system of claim 1 , wherein an absolute pressure ratio of the conditioned air within the nozzle to the cabin air in the passenger cabin is approximately 1.002.3. The passenger cabin air distribution system of claim 1 , wherein the ejector-diffuser further comprises:a first end having a primary inlet coupled to the ventilation system to receive the conditioned air;a second end opposite the first end, the discharge at the second end;the nozzle positioned between the first end ...

SECURE DATA DISTRIBUTION PROTOCOL USING BLOCKCHAINS

One or more systems and methods are presented for secure data communications utilizing blockchains. One or more systems and methods may utilize multiple blockchains to provide an immutable cryptographically linked set of blocks. Each of these blocks may contain one or more actions associated with a computer network. In one embodiment, a trusted third party may be utilized to authenticate and/or verify data prior to inputting data into one or more blockchains. 1. A method comprising:receiving from a sending device, one or more first communications that correspond to a request to generate a custom blockchain, the one or more first communications including a plurality of token parameters;initializing a sender node;initializing a receiver node;writing the sender node into a first block in an underlying pre-existing blockchain, the sender node being associated with a first blockchain address;writing the receiver node into a second block in the an underlying pre-existing blockchain, the receiver node being associated with a second blockchain address;receiving, by the sender node, at least one token parameter of the plurality of token parameters and at least one distribution parameter;initializing, based on the at least one token parameter, a first distributed ledger, the first distributed ledger identifying one or more actions associated with a custom blockchain, the custom blockchain being distinct from the an underlying pre-existing blockchain;receiving, by receiver node, a cryptographically signed request for custom tokens associated with the custom blockchain, the cryptographically signed request being generated based at least on, a private key associated with a receiving device;comparing, by the receiver node, one or more receiver conditions associated with the cryptographically signed request to one or more actions identified in the first distributed ledger to determine that the one or more receiver conditions are satisfied;transmitting, from the receiver node to ...

DEVICES AND METHODS FOR COLLECTING ACOUSTIC DATA

A device includes a network interface to communicate with a communication network and a microphone to convert sounds into an electrical signal. The device further includes a processor coupled to the microphone and the network interface. The processor is configured to process the electrical signal to generate acoustic data based on the electrical signal and to provide the acoustic data to the network interface for transmission to a data storage device. 120-. (canceled)21. A method , comprising:receiving, from a device, sound samples of an acoustic environment, wherein the sound samples were captured in response to a trigger generated at the device;receiving, from the device, a selection to activate an opt-in privacy setting from the device, wherein the opt-in privacy setting enables a processor to remove identifying data specific to the device and encrypt acoustic data transmitted via a network;based on the received sound samples, generating a hearing aid profile for the acoustic environment;storing the sound samples and the generated hearing aid profile in a data storage device; andtransmitting, via the network, the generated hearing aid profile to the device.22. The method of claim 21 , further comprising providing the generated hearing aid profile to a hearing health professional.23. The method of wherein the sound samples of the acoustic environment are periodically received from the device.24. The method of wherein the sound samples of the acoustic environment are periodically received from the device according to a specified period of time claim 23 , and wherein the specified period of time is defined by a specified time of day and/or a specified duration.25. The method of wherein the sound samples of the acoustic environment are continuously received from the device.26. The method of wherein the device is a first device claim 21 , and wherein receiving sound samples of the acoustic environment from the first device comprises receiving sound samples captured by ...

Transcutaneous analyte sensor systems and methods

Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

Floribunda rose plant named GRAapr

‘GRAapr’ is a new and distinct floribunda type Rosa hybrid cultivar which is characterized by the combination of an upright to semi-weeping growth habit, complete resistance to , nearly continuous flowering, double-type apricot flowers with a strong citrus-like fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAapr’, as described and illustrated herein. This application claims priority to the Australian Plant Breeder's Rights application number 2015002, filed on Jan. 7, 2015, which is herein incorporated by reference.The Latin name of the genus and species of the novel variety disclosed herein is hybrid.The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAapr’.The present invention relates to a new and distinct hybrid, floribunda rose cultivar, which has been given the variety denomination of ‘GRAapr’. Its market class is PLT/141.Parentage: ‘GRAapr’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line and an unnamed hybrid male breeding line. Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as complete resistance to rose black spot disease, complete resistance to powdery mildew, and flowers with a strong citrus-like perfume borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of strong true-rose perfume and a bright, modern flower color. During the summer of 2010, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2010, seed was collected from hips produced by ...

Floribunda rose plant named GRAsalm

‘GRAsalm’ is a new and distinct floribunda type hybrid cultivar which is characterized by the combination of an upright to semi-weeping growth habit, complete resistance to , nearly continuous flowering, double-type salmon flowers with tinges of apricot in hot weather, a strong rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAsalm’, as described and illustrated herein. This application claims priority to the Australian Plant Breeder's Rights application number 2015001, filed on Jan. 7, 2015, which is herein incorporated by reference.The Latin name of the genus and species of the novel variety disclosed herein is hybrid.The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAsalm’.The present invention relates to a new and distinct hybrid, floribunda rose cultivar, which has been given the variety denomination of ‘GRAsalm’. Its market class is PLT/141.Parentage: ‘GRAsalm’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line and an unnamed hybrid male breeding line. Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as complete resistance to rose black spot disease, complete resistance to powdery mildew, and flowers with a strong citrus-like perfume borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of strong true-rose perfume and a bright, modern flower color. During the summer of 2010, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2010, seed was ...

Floribunda Rose Plant Named 'GRAdkpk'

‘GRAdkpk’ is a new and distinct floribunda type Rosa hybrid cultivar which is characterized by the combination of an upright to semi-weeping growth habit, excellent resistance to Diplocarpon rosae , nearly continuous flowering, lavender pink double-type flowers which fade to mauve pink, a strong rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications.

Intermittent monitoring

Various examples are directed to systems and methods for monitoring a patient. For example, patient data of a first type may be monitored with a low-fidelity monitoring technique over a first time period. Patient behavior may be evaluated based on the monitored first type of patient data. Patient data of a second type may be monitored over a second time period with a continuous glucose monitor device. A parameter of the continuous glucose monitor device may be based on the evaluated patient behavior during the monitoring.

Floribunda Rose Plant Named 'GRAmary'

‘GRAmary’ is a new and distinct floribunda type hybrid cultivar which is characterized by the combination of an upright to semi-weeping growth habit, excellent resistance to , nearly continuous flowering, bright cerise double-type flowers, a mild rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAmary’, as described and illustrated herein. This application claims priority to the Australian Plant Breeder's Rights application number 2015/090, filed on Apr. 27 2015, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAmary’.The present invention relates to a new and distinct hybrid, floribunda rose cultivar, which has been given the variety denomination of ‘GRAmary’. Its market class is PLT/141.Parentage: ‘GRAmary’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line and an unnamed hybrid male breeding line. Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as complete resistance to rose black spot disease, complete resistance to powdery mildew, and flowers with a strong citrus-like perfume borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of strong true-rose perfume and a bright, modern flower color. During the summer of 2010, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of ...

Heater plate for respiratory humidification systems

A respiratory humidification system humidifies a flow of respiratory gases supplied to a user. The system can include a main housing that receives a humidification chamber, a heating plate included in the main housing and positioned to contact the humidified chamber and transfer heat to the humidifier chamber, and a heating element that provides heat to the heating plate. The heating element can include a temperature sensor disposed in a central region of the heating element. Disposing the temperature sensor in the central region can reduce a likelihood that conductors of the heating element will cause an incorrect temperature measurement by the temperature sensor.

Dispensing Nozzle with Magnetic Assist

A nozzle system including a nozzle body having a fluid path through which fluid to be dispensed is flowable. The system includes a fluid valve positioned in the fluid path and movable between a first position and a second position, and a manually operable lever operatively coupleable to the fluid valve and movable between a first position and a second position. The system further has a biasing mechanism configured to apply a force biasing at least one of the valve or the lever to one of the associated first or second positions, and a magnetic assist system configured to apply a magnetic force opposing the biasing force applied by the biasing mechanism.

Floribunda rose plant named 'GRAosr'

‘GRAosr’ is a new and distinct type hybrid cultivar which is characterized by the combination of an upright, bushy growth habit, nearly continuous flowering, with flowers that exhibit a distinct strong red with petals yellow at the base and with a silver white reverse, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAosr’, as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/626,780 filed Feb. 6, 2018, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination:The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAosr’.Parentage: ‘GRAosr’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line and an unnamed hybrid male breeding line. Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as very strong fragrance and having flower color white, borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2014, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2015, seed was collected from hips produced by the female parent and a number of seedlings were grown to a mature size, including the claimed plant. These progeny were further evaluated for desirable traits such as black spot disease resistance and original flower color, and in January of 2016 the claimed ...

Floribunda rose plant named 'GRAfIr'

‘GRAflr’ is a new and distinct type hybrid plant which is characterized by the combination of an upright to semi-weeping growth habit, excellent resistance to and nearly continuous flowering, strong yellow flowers edged red, a moderate rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAflr’, as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/626,725 filed Feb. 6, 2018, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination:The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAflr’.Parentage: ‘GRAflr’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as very high resistance to rose black spot disease, complete resistance to powdery mildew, and having flower color strong yellow with outer petals edged red, borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2014, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2015, seed was collected from hips produced by the female parent and a number of seedlings were grown to a mature size, including the claimed plant. These progeny were further evaluated for ...

Floribunda rose plant named 'GRAtusc'

‘GRAtusc’ is a new and distinct floribunda type hybrid cultivar which is characterized by the combination of an upright to semi-weeping, bushy growth habit, nearly continuous flowering, with flowers that exhibit a distinct pink blended yellow color becoming terracotta with summer heat and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAtusc’, as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/626,802 filed Feb. 6, 2018, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAtusc’.Parentage: ‘GRAtusc’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as very strong fragrance and having flower color white, borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2013, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2014, seed was collected from hips produced by the female parent and a number of seedlings were grown to a mature size, including the claimed plant. These progeny were further evaluated for desirable traits such as black spot disease resistance and original ...

Floribunda rose plant named 'GRAzest'

‘GRAzest’ is a new and distinct type hybrid plant which is characterized by the combination of an upright to semi-weeping and bushy growth habit, nearly continuous flowering, large single type flowers with a bright true red coloration, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAzest’ as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/626,915 filed Feb. 6, 2018, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAzest’.Parentage: ‘GRAzest’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as very strong fragrance and having flower color white, borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2014, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2015, seed was collected from hips produced by the female parent and a number of seedlings were grown to a mature size, including the claimed plant. These progeny were further evaluated for desirable traits such as black spot disease resistance and original flower color, and in January of 2016 the claimed ...

Floribunda Rose Plant Named 'GRAnib'

‘GRAnib’ is a new and distinct type hybrid cultivar which is characterized by the combination of an upright and bushy growth habit, nearly continuous flowering, double flowers that exhibit a strong dark red with velvet overlay tending black, flowers with a strong rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAnib’ as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/626,773 filed Feb. 6, 2018, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAnib’.Parentage: ‘GRAnib’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as excellent disease resistance, a bushy plant growing to 1.2 m tall and wide, and flowers with strong perfume. The male parent was selected for use in breeding after trialing confirmed the presence of a unique, modern flower color. During the summer of 2014, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2015, seed was collected from hips produced by the female parent and a number of seedlings were grown to a mature size, including the claimed plant. These progeny were further evaluated for desirable traits such as black spot disease resistance and original ...

Transcutaneous analyte sensors, applicators therefor, and associated methods

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Floribunda Rose Plant Named 'GRAylw '

‘GRAylw’ is a new and distinct floribunda type hybrid cultivar which is characterized by the combination of an upright to semi-weeping, bushy growth habit, nearly continuous flowering, with flowers that exhibit a distinct strong, bright yellow color and moderate to strong fragrance and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAylw’, as described and illustrated herein. Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAylw’.Parentage: ‘GRAylw’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as very strong fragrance and having flower color white, borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2015, the female parent was emasculated and was manually pollinated with pollen from the male parent. In winter of 2016, seed was collected from hips produced by the female parent and a number of seedlings were grown to a mature size, including the claimed plant. These progeny were further evaluated for desirable traits such as black spot disease resistance and original flower color, and in January of 2017 the claimed plant was first observed. In March of 2018, after further evaluation for desirable traits, the claimed ...

FLORIBUNDA ROSE PLANT NAMED 'GRATGX'

‘GRAtgx’ is a new and distinct floribunda type hybrid cultivar which is characterized by the combination of an upright to semi-weeping growth habit, good resistance to and , nearly continuous flowering, distinct cerise flowers with yellow stripes and flecks and a cream yellow reverse, a moderate rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAtgx’ as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/629,845 filed Feb. 13, 2018, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAtgx’.Parentage: ‘GRAtgx’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as high resistance to rose black spot disease, complete resistance to powdery mildew, and cerise pink flowers with yellow stripes and flecks and a yellow petal reverse, borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2014, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2015, seed was collected from hips produced by the female parent and a number of seedlings were grown to a mature size, ...

Ledger-independent token service

Techniques for implementing a ledger-independent token service are provided. According to one set of embodiments, a computer system executing the service can receive, from a user, a request to create a token on a distributed ledger network. The computer system can further provide to the user one or more token templates, where each token template corresponds to a type of physical or digital asset and defines a set of one or more attributes and one or more control functions associated with the type. The computer system can then receive, from the user, a selection of a token template in the one or more token templates and create the token on the distributed ledger network, where the created token includes the set of one or more attributes and one or more control functions defined in the selected token template.

Floribunda rose plant named 'GRABGTG'

‘GRAbgtg’ is a new and distinct floribunda type hybrid plant which is characterized by the combination of an upright growth habit, good resistance to and moderate , nearly continuous flowering, distinct flower color dominated by burgundy red with irregular pink variegated areas that are splashed and flecked with burgundy red, a very strong rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAbgtg’, as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/809,207 filed Feb. 22, 2019, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAbgtg’.Parentage: ‘GRAbgtg’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as very strong fragrance, very high resistance to powdery mildew, and having flower color dominated by burgundy red with irregular pink variegated areas that are splashed and flecked with burgundy red borne on a bushy plant growing to 1.2 meters tall and 1 meter wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2015, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2016, seed was collected from ...

Floribunda rose plant named 'GRAalpha'

‘GRAalpha’ is a new and distinct floribunda type hybrid plant which is characterized by the combination of an semi-weeping to spreading growth habit, very high resistance to and , nearly continuous flowering, distinct flower color dominated by yellow with irregular orange variegated areas that are splashed and flecked with yellow, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAalpha’, as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/809,200 filed Feb. 22, 2019, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAalpha’.Parentage: ‘GRAaplha’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed Rosa hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as compact growth habit well suited to the landscape, very high resistance to powdery mildew and blackspot and having flower color dominated by yellow with irregular orange variegated areas that are splashed and flecked with yellow and borne on a bushy plant growing to 1 meter tall and 1 meter wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2015, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2016, seed was ...

Floribunda Rose Plant Named 'GRApstg'

‘GRApstg’ is a new and distinct floribunda type hybrid plant which is characterized by the combination of an upright growth habit, good resistance to and nearly continuous flowering, distinct cream stripes and flecks and petal reverse pink with cream stripes and flecks, a very strong rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRApstg’, as described and illustrated herein. This application claims the benefit of U.S. Provisional Application No. 62/809,213 filed Feb. 22, 2019, which is herein incorporated by reference.Latin name of genus and species: The Latin name of the genus and species of the novel variety disclosed herein is hybrid.Variety denomination: The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRApstg’.Parentage: ‘GRApstg’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line (not patented) and an unnamed hybrid male breeding line (not patented). Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as very strong fragrance, very high resistance to powdery mildew, and having flower pink with cream stripes and flecks borne on a bushy plant growing to 1.2 meters tall and 1 meter wide. The male parent was selected for use in breeding after trialing confirmed the presence of a modern flower color. During the spring of 2015, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2016, seed was collected from hips produced by the female parent and a number of seedlings were grown to a mature size, including the claimed plant. These progeny were ...

Floribunda rose plant named GRAaus

‘GRAaus’ is a new and distinct floribunda type cultivar which is characterized by the combination of an upright to semi-weeping growth habit, excellent resistance to , nearly continuous flowering, white double-type flowers with tinges of pale pink as flowers age, a moderate rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa hybrid. A new and distinct variety of plant named ‘GRAaus’, as described and illustrated herein. This application claims priority to the Australian Plant Breeder's Rights application number 2015/087, filed on Apr. 27 2015, which is herein incorporated by reference.The Latin name of the genus and species of the novel variety disclosed herein isThe inventive variety of disclosed herein has been given the variety denomination ‘GRAaus’.The present invention relates to a new and distinct , floribunda rose cultivar, which has been given the variety denomination of ‘GRAaus’. Its market class is PLT/141.Parentage: ‘GRAaus’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed female breeding line and an unnamed male breeding line. Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as complete resistance to rose black spot disease, complete resistance to powdery mildew, and flowers with a strong citrus-like perfume borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of strong true-rose perfume and a bright, modern flower color. During the summer of 2010, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2010, seed was collected from hips produced by the female parent ...

Floribunda rose plant named 'GRAred'

‘GRAred’ is a new and distinct floribunda type hybrid cultivar which is characterized by the combination of an upright to semi-weeping growth habit, excellent resistance to , nearly continuous flowering, red-purple double flowers, a moderate rose fragrance, and the stability of these characteristics from generation to generation. The new cultivar is generally suited to landscape applications. 1Rosa. A new and distinct variety of hybrid plant named ‘GRAred’, as described and illustrated herein. This application claims priority to the Australian Plant Breeder's Rights application No. 2015/098, filed on Apr. 27 2015, which is herein incorporated by reference.The Latin name of the genus and species of the novel variety disclosed herein is hybrid.The inventive variety of hybrid disclosed herein has been given the variety denomination ‘GRAred’.The present invention relates to a new and distinct hybrid, floribunda rose cultivar, which has been given the variety denomination of ‘GRAred’. Its market class is PLT/141.‘GRAred’ is a seedling selection which resulted from the controlled cross-pollination of an unnamed hybrid female breeding line and an unnamed hybrid male breeding line. Both parents, developed by the same inventor and never commercially released, exhibited traits deemed commercially significant and desirable.After many years of trialing, the female parent was confirmed to possess a combination of desirable traits such as complete resistance to rose black spot disease, complete resistance to powdery mildew, and flowers with a strong citrus-like perfume borne on a bushy plant growing to 1.2 m tall and wide. The male parent was selected for use in breeding after trialing confirmed the presence of strong true-rose perfume and a bright, modern flower color. During the summer of 2010, the female parent was emasculated and was manually pollinated with pollen from the male parent. In autumn of 2010, seed was collected from hips produced by the female parent and a number ...

Dispensing nozzle with self draining shutoff device

A fluid dispensing nozzle including a nozzle body having a fluid path and a suction path therein. The nozzle includes a suction generator configured to generate a suction force in at least part of the suction path when fluid to be dispensed flows through the fluid path. The nozzle further includes a shut-off device including a suction chamber fluidly coupled to the suction path and configured such that when the suction path is blocked during fluid dispensing the shut-off device moves to a closed configuration to prevent the nozzle from dispensing fluid through the fluid path. The suction path includes a terminal portion in fluid communication with the suction chamber, and the terminal portion has a cross sectional area of at least about 0.015 square inches.

NEW COMPOUNDS AS NIK INHIBITORS

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders. 2. A pharmaceutical composition comprising a compound as claimed in and a pharmaceutically acceptable carrier or diluent.3. (canceled)4. A compound as claimed for use in the prevention or treatment of cancer.5. A pharmaceutical composition as claimed in for use in the prevention or treatment of cancer.6. A method of treating or preventing a cell proliferative disease in a warm-blooded animal which comprises administering to the said animal an effective amount of a compound as claimed . The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in ...

NEW PYRAZOLOPYRIMIDINE DERIVATIVES AS NIK INHIBITORS

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders. 2. The compound according to claim 1 , wherein{'sup': '1', 'sub': 1-4', '1-4, 'Ris selected from the group of hydrogen; Calkyl; and Calkyl substituted with one or more fluoro substituents;'}{'sup': 2', '1, 'sub': 1-4', '1-4', '3-6, 'Ris selected from the group of Calkyl; Calkyl substituted with one or more fluoro substituents; Ccycloalkyl; and Het;'}{'sup': 1', '2, 'sub': '3-6', 'or Rand Rtogether with the carbon atom to which they are attached form a Ccycloalkyl;'}{'sup': '1', 'sub': 1-4', '1-4', '1-4', '1-4, 'Hetis a heteroaryl selected from the group of thienyl, thiazolyl, pyrrolyl, oxazolyl, oxadiazolyl, pyrazolyl, imidazolyl, isoxazolyl, isothiazolyl, pyridinyl and pyrimidinyl, each of which may be optionally substituted with one or two substituents independently selected from halogen, cyano, Calkyl, Calkyloxy, Calkyl substituted with one or more fluoro substituents, and Calkyloxy substituted with one or more fluoro substituents;'}{'sup': '9', 'X is N or CR;'}{'sup': '9', 'Ris selected from hydrogen and halogen;'}{'sup': 3', '3a', '3b, 'sub': 3-6', '1-6', '1-6', '1-6', '1-6', '1-6', '1-4, 'Ris selected from the group of hydrogen; halogen; cyano; Ccycloalkyl; Calkyl; Calkyl substituted with one or more fluoro substituents; —OCalkyl; —OCalkyl substituted with one or more fluoro substituents; and ...

Rosa plant named 'GRAppl'

A new and distinct floribunda type named ‘GRAppl’ is disclosed, characterized by complete resistance to and strong tolerance for powdery mildew. Plants produce dark red-purple flowers with a strong fragrance and are typically dense and twiggy, reaching a height of between 1 to 1.2 meters. The new cultivar is a typically suited for ornamental container and landscape use. 1Rosa hybrid. A new and distinct cultivar of plant named ‘GRAppl’ as herein illustrated and described. ‘GRAppl’The new cultivar is the result of a planned breeder program, conducted by the inventors, John Gray and Sylvia Gray, citizens of Australia. The new variety resulted from the corssing of a proprietary, unpatented, unnamed seedling with the pollen parent GRAsuper U.S. Plant Pat. No. 23,175. The crossing was made Dec. 12, 2011. The discovery was made Mar. 12, 2012.After selecting the new cultivar, asexual reproduction of ‘GRAppl’ was first performed in the same commercial nursery by vegetative cuttings Mar. 30, 2012. ‘GRAppl’ has since produced two generations and has shown that the unique features of this cultivar are stable and reproduced true to type.The cultivar ‘GRAppl’ has not been observed under all possible environmental conditions. The phenotype may vary somewhat with variations in environment such as temperature, day length, and light intensity, without, however, any variance in genotype.The following traits have been repeatedly observed and are determined to be the unique characteristics of ‘GRAppl’. These characteristics in combination distinguish ‘GRAppl’ as a new and distinct cultivar:1. Complete resistance to the fungus2. Strong perfume scent to flowers.3. Plant height to 1.2 meters with 1 meter width.4. Above average plant vigor.5. Fully double, dark red-purple flower color.6. Strong resistance to powdery mildew.7. Green foliage with distinctive bluish tinge.8. Twiggy, shrubby growth habit.Plants of the new cultivar ‘GRAppl’ are similar to the unnamed seed parent in most ...

Systems and methods relating to an analyte sensor system having a battery located within a disposable base

An analyte sensor system is provided. The system includes a base configured to attach to a skin of a host. The base includes an analyte sensor configured to generate a sensor signal indicative of an analyte concentration level of the host, a battery, and a first plurality of contacts. The system includes a sensor electronics module configured to releasably couple to the base. The sensor electronics module includes a second plurality of contacts, each configured to make electrical contact with a respective one of the first plurality of contacts, and a wireless transceiver configured to transmit a wireless signal based at least in part on the sensor signal. The system includes a first sealing member configured to provide a seal around the first and second plurality of contacts within a first cavity. Related analyte sensor systems, analyte sensor base assemblies and methods are also provided.

Applicators for applying transcutaneous analyte sensors and associated methods of manufacture

Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Transcutaneous analyte sensors, applicators therefor, and associated methods

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Mechanized floor console

A vehicle passenger compartment floor console includes a module receptacle and a plurality of interchangeable storage and appliance modules designed to fit within the module receptacle. The floor console may also include a drum-type carrousel supported for rotation about a generally horizontal axis within the console outer shell. The carrousel holds three storage modules and is positioned to sequentially rotate each module past an access opening cut or formed through the console outer shell. A passenger compartment occupant may use the console to selectively present any one of a number of interchangeable modules for occupant access while traveling.

Structural instrument panel carrier assembly

A motor vehicle body has an instrument panel construction that includes a structural instrument panel carrier of plastic material for mounting instrument panel components. The carrier is attached to side pillars located at a juncture of passenger and engine compartments so as to form a cross beam. The instrument panel construction has its external appearance determined by adding facial instrument panel coverings to the instrument panel carrier after the instrument panel components are mounted on the instrument panel carrier. The structural instrument panel carrier may also be integrated with a front of dash (FOD) panel that may be composed of the same material and that provides a second cross beam.

Mechanized floor console

A vehicle passenger compartment console assembly including a console body having an outer shell and an access opening disposed in the console body outer shell. A positioning apparatus is movably supported within the console body outer shell. At least two storage modules are disposed within the shell and are movably supported on the positioning apparatus. The storage modules are sequentially movable between one or more concealed positions displaced from the access opening and a displayed position adjacent the access opening. The positioning apparatus is configured to support any one of the storage modules in the display position while simultaneously supporting at least one of the other storage modules in a concealed position. This arrangement allows passenger compartment occupants to gain physical access to a module and its contents through the access opening while leaving other modules concealed within the shell.

Pre-connected analyte sensors

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Pre-connected analyte sensors

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Pre-connected analyte sensors

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Medical pump with fixed stroke length

A method comprises measuring a volume of fluid delivered per pump stroke for each of a plurality of substantially identical medical pumps. The substantially identical medical pumps each have a fixed stroke length. The method further comprises: storing indications of the measured volumes on one or more data storage mediums; and for each of the plurality of substantially identical medical pumps, generating a separate therapy control program based on the indication of the measured volume associated with that one of the plurality of substantially identical medical pumps.

Infusion device and driving mechanism for same

A drive mechanism for delivery of infusion medium has a coil and an armature moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is moveable axially within a piston channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position, the piston chamber volume is reduced and pressure within the piston chamber increases to a point where the pressure moves the valve member into an open position through an outlet.

Pre-connected analyte sensors

Transcutaneous analyte sensor systems and methods

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Transcutaneous analyte sensors, applicators therefor, and associated methods

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Process for the production of chlorine dioxide

Linepipe and structural steel produced by high speed continuous casting

A high strength, high toughness, low carbon/low manganese steel is provided that is further resistant to stepwise cracking and sulfide stress cracking. The steel can be produced by conventional or thin slab casting techniques using normal speeds, with low manganese segregation levels. The steels are excellent candidates for linepipe applications in severe sour gas service.

Apparatus for molding multicolor thin wall plastic shell

An apparatus (40) for molding a thin walled plastic shell includes a mold box (42) having an inner mold surface (48). A powder box (52) includes an internal chamber and first divider wall (54) for separating the internal chamber into at least two sections (56,58). A carrier framework (60) is removably mounted on the mold box (42) and includes a peripheral seal for perfecting a seal between the mold box (42) and the powder box (52) when the same are connected thereto. A second divider wall (64) is connectable to the first divider wall (54) separating the inner mold surface into two chambers continuous with the two sections of the powder box (52). The carrier framework (60) further includes a mold surface seal (66) for perfecting a seal between the second divider wall (64) and mold surface (48).

Pre-connected analyte sensors

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Transcutaneous analyte sensors, applicators therefor, and associated methods

An on-skin sensor assembly (260) and an applicator (5500) for applying the on-skin sensor assembly (260) to a skin of a host are provided. The on-skin sensor assembly (260) includes a sensor (238) configured to measure an analyte concentration of the host; and an outer housing (292, 294) comprising an aperture (296) which is offset from a center of the outer housing (292, 294). The applicator comprises an applicator housing; a needle carrier assembly comprising an insertion element (5574) configured to insert the sensor (238) of the on-skin sensor assembly (260) into the skin of the host, wherein the aperture (296) in the outer housing (292, 294) of the on-skin sensor assembly (260) is configured to allow the insertion element (5574) and /or the sensor (238) to pass through; a sensor retention element (5592), wherein the insertion element (5574) is configured to be inserted at least partially into the sensor retention element (5592) such that the sensor (238) is retained within the insertion element (5574) prior to activation of the applicator (5500); and a bottom cap (5590), wherein the sensor retention element (5592) configured to be removed with the bottom cap (5590) prior to activation of the applicator (5500).

Transcutaneous analyte sensors, applicators therefor, and associated methods

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Transcutaneous analyte sensors, applicators therefor, and associated methods

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Transcutaneous analyte sensors, applicators therefor, and associated methods

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Transcutaneous analyte sensors, applicators therefor, and associated methods

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position.

Transcutaneous analyte sensor systems and methods

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Systems and methods for health data visualization and user support tools for continuous glucose monitoring

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Applicators for applying transcutaneous analyte sensors and associated methods of manufacture

Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Network physical layer configurations for ambulatory physiological parameter monitoring and therapeutic intervention systems

Certain embodiments herein relate to a physiological parameter monitoring system. The system may include a sensor and sensor electronics connectable to the sensor. The system may also include a transmitter operably connected to the sensor electronics, the transmitter having or being configured to have at least a portion thereof positioned at a first location adjacent to and/or in contact with an external surface of a body of a host during a sensor session, the transmitter further configured to wirelessly transmit sensor information using human body communication. The system may further include a first display device comprising a display and a receiver, the receiver having or being configured to have at least a portion thereof positioned at a second location adjacent to and/or in contact with the external surface of the body during the sensor session, the receiver further configured to receive sensor information from the transmitter using human body communication.

Transcutaneous analyte sensor systems and methods

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Transcutaneous analyte sensor systems and methods

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Systems and methods for health data visualization and user support tools for continuous glucose monitoring

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Systems and methods for health data visualization and user support tools for continuous glucose monitoring

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Systems and methods for power management in analyte sensor system

An analyte sensor system may include a first communication circuit configured to transmit a wireless signal in a first communication mode and a second communication mode, and a processor, wherein the processor determines whether a first condition is satisfied, the first condition relating to the sensor signal or to communication by the first communication circuit, and shifts the system to a second communication mode responsive to the first condition being satisfied.

System and method for decision support

Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.

Pre-connected analyte sensors

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Pre-connected analyte sensors

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Applicators for applying transcutaneous analyte sensors and associated methods of manufacture

Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Applicators for applying transcutaneous analyte sensors and associated methods of manufacture

Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Multi-colour plastic shells

Syringes and syringe pumps

Structural instrument panel carrier assembly.

Dispensing nozzle with fluid recapture

A nozzle including a dispensing path configured such that fluid is dispensable therethrough. The nozzle further includes a suction path configured such that a negative pressure is created therein when fluid flows through the dispensing path. The nozzle has a fluid recapture path configured to capture therein fluid positioned on an outside of the nozzle. The fluid recapture path is in fluid communication with the dispensing path and the suction path such that fluid in the fluid recapture path is directable into the dispensing path by the negative pressure.

Heat pump

Internal row sequencer for reducing bandwidth and peak current requirements in a display driver circuit

A display driver circuit includes a word line sequencer for providing a series of row addresses, and a row decoder for decoding each of the row addresses and asserting write signals on corresponding ones of a plurality of output terminals. An optional data path sequencer provides a series of path addresses which are used by an optional data router to route data to particular sub-rows of a display. Additionally, an optional sub-row sequencer provides a series of sub-row addresses to an optional sub-row decoder, which decodes each of the sub-row addresses and asserts write signals on corresponding ones of a second plurality of output terminals.

Motor vehicle interior components

A method of forming a motor vehicle instrument panel with a flexibly tethered air bag deployment door by molding first and second plastics materials is described. Also described is a vehicle passenger compartment console assembly including a console body having an outer shell and an access opening disposed in the console body outer shell, and having at least two storage modules disposed within the shell and sequentially movably supported between one or more concealed positions displaced from the access opening and a displayed position adjacent the access opening. Also described is an automotive headliner assembly which includes a substrate that is configured to mount to a vehicle in a position generally covering a lower surface of a passenger compartment roof. Cavities are integrally formed into the substrate between the upper substrate surface and the lower substrate surface to provide receptacles for electrical wiring, fiber optic cabling, EA foam and the like or to form a duct for directing air flow. Also described is an inflatable restraint assembly comprising a trim panel, an air bag door positioned spanning an air bag deployment opening in the trim panel, a frangible tear seam defining at least a portion of the air bag door, and a hard plastic collar is attached to the trim panel, wherein the air bag door is integrally formed with the hard plastic collar.